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Preprint COMMUNICATION | doi:10.20944/preprints202112.0406.v1

Endothelium Activation during Severe Yellow Fever Triggers an Intense Cytokine-Mediated Inflammatory Response in the Liver Parenchyma

Fábio Alves Olimpio, Luiz Fábio Magno Falcão, Marcos Luiz Gaia Carvalho, Jeferson da Costa Lopes, Caio Cesar Henriques Mendes, Arnaldo Jorge Martins Filho, Carlos Augusto Moreira da Silva, Vanessa do Socorro Cabral Miranda, Lais Carneiro dos Santos, Felipe Souza da Silva Vilacoert, Ana Cecília Ribeiro Cruz, Vanessa Costa Alves Galucio, Raimundo do Socorro da Silva Azevedo, Livia Caricio Martins, Maria Irma Seixas Duarte, Jorge Rodrigues de Sousa, Pedro Fernando da Costa Vasconcelos, Juarez Antônio Simões Quaresma

Subject: Biology And Life Sciences, Virology Keywords: Yellow fever; Liver; Vascular endothelium; Adhesion molecule.

Online: 24 December 2021 (11:41:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.1987.v1

Urban Governance and Sanitation in the Peri-Urban Commune of Agoè-Nyvé 6 in Togo: Diagnosis of the Sanitation System in Adétikopé

Efui Holaly GBEKLEY, Koko Zébéto HOUEDAKOR, Kossi KOMI, Sossawè POLI, Koffi ADJALO, Ablam NYAKPO, Ayayivi Mensah AYIVIGAN, Abdourahamane Aissa Ghanny Vanessa ALI, Kossiwa ZINSOU-KLASSOU, Pèssiezoum ADJOUSSI

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: urban governance; sustainable development; wastewater management; Adétikopé; Togo

Online: 28 July 2023 (10:08:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints201907.0195.v1

Interactions of Nanoparticles and Biosystems: Microenvironment of Nanoparticles and Biomolecules in Nanomedicine

Carlota Auria-Soro, Tabata Nesma, Pablo Juanes-Velasco, Alicia Landeira-Viñuela, Helena Fidalgo-Gomez, Vanessa Acebes-Fernandez, Rafael Gongora, Maria Jesus Almendral Parra, Raul Manzano-Roman, Manuel Fuentes

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: Nanoparticles, interactions, protein corona, nanomedicine

Online: 16 July 2019 (12:36:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1850.v1

Design of a Remote Time-Restricted Eating and Mindfulness Intervention to Reduce Risk Factors Associated with Early-Onset Colorectal Cancer Development among Young Adults

Manoela Lima Oliveira, Alana Biggers, Vanessa M Oddo, Keith B Naylor, Zhengjia (Nelson) Chen, Alyshia Hamm, Lacey Pezley, Beatriz Peñalver Bernabé, Kelsey Gabel, Lisa K Sharp, Lisa Marie Tussing-Humphreys

Subject: Biology And Life Sciences, Behavioral Sciences Keywords: time-restricted eating; mindfulness; early-onset colorectal cancer; feasibility; acceptability; stress reduction; weight management

Online: 26 January 2024 (06:55:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0352.v1

Evaluation of Cell Rupture Techniques on the Extraction of Proteins from Microalgae Tetradesmus obliquus

César Augusto Sodré da Silva, Karen Vanessa Marimón Sibaja, Sabrina de Ramos Cizilio, José Roberto Miranda Júnior, Rejane de Castro Santana, Marcio Arêdes Martins, Maurício de Oliveira Leite, Eduardo Basílio de Oliveira, Jane Sélia dos Reis Coimbra

Subject: Biology And Life Sciences, Food Science And Technology Keywords: ball milling; high-pressure homogenization; ultrasonication; cell counting

Online: 9 October 2023 (08:56:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0628.v1

Traffic and industrial contributions of particle-bound PAHs during an air pollution event in Metropolitan Area of Medellin-Colombia: Inhalation intake risk during pregnancy

Jhon Fredy Narváez-Valderrama, Sandra Viviana Alzate-B, Vanessa Correa-Gil, Juan José García-L, Juan Mauricio Bedoya-Soto, Francisco José Molina-P, Gladys Guillermin A Pauta-Calle, Gabriela Belén Vázquez-Guillén, Carlos D. Ramos-Contreras

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Air pollution; Polycyclic Aromatic Hydrocarbons (PAHs); Adverse Perinatal Out-come; Inhalation Intake model; Long-term Exposure

Online: 11 September 2023 (07:48:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0300.v1

Sars-Cov-2 Inactivation by a Panel of Commercialized Buffers and by Traditional Protocols (Heat or SDS)

Grégory Quéromès, Emilie Frobert, Maude Bouscambert-Duchamp, Martine Valette, Geneviève Billaud, Vanessa Escuret, Antoine Oblette, Bruno Lina, Florence Morfin, Alexandre Gaymard

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; inactivation; commercial buffer; heat; SDS

Online: 22 March 2022 (11:21:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202105.0206.v1

The Mucosal Barrier and Anti-Viral Immune Responses can Eliminate Portions of the Viral Population during Transmission and Early Viral Growth

Athena E. Golfinos, Dane D. Gellerup, Hannah Schweigert, Jaffna Mathiaparanam, Alexis J. Balgeman, Andrea M. Weiler, Thomas C. Friedrich, Brandon F. Keele, Miles P. Davenport, Vanessa Venturi, Shelby L. O'Connor

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Simian Immunodeficiency Virus; SIVmac239; barcoded viruses; intravenous challenge; intrarectal challenge

Online: 10 May 2021 (15:01:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0147.v1

Impact of a Moderately Hypocaloric Mediterranean Diet on the Gut Microbiota Composition of Italian Obese Patients

Silvia Pisanu, Vanessa Palmas, Veronica Madau, Emanuela Casula, Andrea Deledda, Roberto Cusano, Paolo Uva, Sarah Vascellari, Francesco Boi, Andrea Loviselli, Aldo Manzin, Fernanda Velluzzi

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: gut microbiota; obesity; weight-loss; Mediterranean diet; 16S rRNA; High-throughput sequencing

Online: 8 July 2020 (11:07:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0314.v1

Activation of the Immune-Inflammatory Response System and the Compensatory Immune-Regulatory Reflex System in Antipsychotic Naive First Episode Psychosis

Mariane Nunes Noto, Michael Maes, Sandra Odebrecht Vargas Nunes, Vanessa Kiyomi Ota, Ana C. Rossaneis, Waldiceu A. Verri Jr., Quirino Cordeiro, Sintia Iole Belangero, Ary Gadelha, Rodrigo Affonseca Bressan, Cristiano Noto

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: schizophrenia; first episode psychosis; antipsychotic; immune; inflammation; cytokines

Online: 17 September 2018 (14:13:38 CEST)

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Background: First episode psychosis (FEP), schizophrenia and affective disorders are accompanied by activation of the immune inflammatory response system (IRS). The compensatory immune-regulatory reflex system (CIRS) is a regulatory immune response that is induced by the IRS but exerts negative feedback through, for example, increased levels of anti-inflammatory cytokines such as IL-4, IL-13 and IL-10. Different phenotypes of schizophrenia may exhibit distinct IRS and CIRS immune profiles.Aims: This study aims to examine the IRS and CIRS components, including macrophagic M1, T-helper (Th)-1, Th-2, Th-17 and T-regulatory (Treg) phenotypes, in antipsychotic-naïve FEP patients before and after risperidone treatment.Methods: We included 31 antipsychotic-naïve FEP patients who had measurements of IRS and CIRS biomarkers before and after treatment with risperidone for 10 weeks, and 22 healthy controls.Results: Antipsychotic-naive FEP patients showed interrelated increments in M1, Th-1, Th-2, Th-17 and Treg phenotypes and a relatively greater IRS response (especially granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-6 and IL-12) as compared with the CIRS response (IL-4, IL-13, IL-5 and IL-10). Inflammatory markers, especially IL-6 and IL-8, were significantly correlated with negative, psychotic, affective and excitation symptom dimensions. Treatment with risperidone significantly suppressed the IRS and CIRS. Baseline levels of CIRS biomarkers, especially higher soluble tumor necrosis factor receptor-1 and IL-10 predicted clinical improvement during treatment.Discussion: Our findings indicate that FEP is characterized by robust IRS (M1 + Th-1 + Th-17) and CIRS responses, suggesting that monocytes, macrophages, Th-1, Th-2, Th-17 and Treg cells are activated. The findings indicate that a) FEP patients are prone to the detrimental effects of M1, Th-1, Th-17 and Th-2 cells, which may contribute to long-lasting abnormalities in brain circuitry; and b) in FEP, the CIRS may contribute to recovery from the acute phase of illness. Enhancing the CIRS is a new drug target to treat FEP.

Preprint ARTICLE | doi:10.20944/preprints201912.0302.v1

Identification of a Novel Papillomavirus Associated with Squamous Cell Carcinoma in a Domestic Cat

Maura Carrai, Kate van Brussel, Mang Shi, Ci-Xiu Li, John S Munday, Katja Voss, Alicia McLuckie, David Taylor, Andrew Laws, Edward C. Holmes, Vanessa Barrs, Julia Beatty

Subject: Biology And Life Sciences, Virology Keywords: papillomavirus; feline; cat; felid; cancer; squamous cell carcinoma; phylogeny; discovery; pathogen; oncogenic

Online: 23 December 2019 (12:01:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0519.v1

The Role of Endogenous Beta-Endorphin in Food Intake and Glucose Homeostasis in Male and Female Mice Fed a High-Fat Diet

Laica Tolentino, Vanessa Escolero, Abdul Bari Muhammad, Abdul Hamid, Kabirullah Lutfy

Subject: Biology And Life Sciences, Life Sciences Keywords: beta-endorphin; high-fat diet (HFD); oral glucose tolerance test; sex differences; food intake; obesity

Online: 8 April 2024 (10:54:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1337.v1

Clinical Profile of SARS-CoV-2 Infection: Mechanisms of the Cellular Immune Response and Immunogenetic Markers in Patients from Brazil

Vanessa Pacheco, Rosane Cuber Guimarães, Danielly Corrêa-Moreira, Carlos Eduardo Magalhães, Douglas Figueiredo, Patricia Guttmann, Gisela Freitas Trindade, Juliana Fernandes Amorim Da Silva, Ana Paula Dinis Ano Bom, Maria de Lourdes Maia, Manoel Marques Evangelista Oliveira

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Sars-Cov-2; COVID-19; Immune response; Cytokine storm; acute infection

Online: 19 June 2023 (10:57:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0470.v1

Mouse Ataxin-2 Expansion Downregulates CamKII and other Calcium Signaling Factors, Impairing Granule – Purkinje Neuron Synaptic Strength

Aleksandar Arsović, Melanie Vanessa Halbach, Julia Canet-Pons, Dilhan Esen-Sehir, Claudia Döring, Florian Freudenberg, Nicoletta Czechowska, Kay Seidel, Stephan L. Baader, Suzana Gispert, Nesli-Ece Sen, Georg Auburger

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Amyotrophic Lateral Sclerosis (ALS); Fronto-Temporal-Lobar-Dementia; Tauopathies; synaptic plasticity; long-term potentiation; spatial learning; inositol signaling; neurexin; K-homology RNA-binding domain; Fragile-X-associated Tremor-Ataxia syndrome

Online: 21 August 2020 (04:39:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1684.v1

How Does ChatGPT Perform on the Italian National Residency Program Admission Test?

Gianmaria Barone, Filippo Confalonieri, Alessandro Gaeta, Vanessa Ferraro, Paolo Vinciguerra, Alessandra Di Maria

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: ChatGPT; Chat Generative Pre-trained Transformer; GPT-3.5; GPT-4; artificial intelligence (AI); chatbot; natural language processing (NLP); medical education; Italian National Residency Program Admission Test; Scuole di Specializzazione in Medicina (SSM)

Online: 27 March 2024 (13:20:49 CET)

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Background: Open AI developed ChatGPT, a language model based on the GPT architecture, designed for text-based communication. Trained on diverse internet texts, ChatGPT generates contextually appropriate responses using machine learning. It understands input through analysis and context interpretation, generating coherent and contextually relevant responses. Interaction is possible through messaging platforms. Materials and Methods: In November 2023, we utilized ChatGPT 3.5, the default version at that time, to answer questions from the Italian National Residency Program Admission Tests (SSMs) of 2021, 2022, and 2023. The questions cover clinical, diagnostic, analytical, therapeutic, and epidemiological scenarios, sometimes accompanied by images. The study compared ChatGPT's answers to the official corrections on the Italian Ministry of University and Research (MUR) website. The scoring method used for evaluation was 1 point for correct answers, 0 points for unanswered questions, and -0.25 points for incorrect answers, reflecting the SSM test scoring system. Results: In summary, ChatGPT was tested with a total of 420 questions, 140 for each test. It achieved an overall accuracy of 80.48%, providing correct answers for 338 questions and incorrect answers for 82 questions. When faced with questions containing both text and images, it answered 55% correctly and 45% incorrectly. The model's performance varied over time, with an 82.14% accuracy rate in 2021 and 2022 (115 correct out of 140) and a 77.14% accuracy rate in 2023 (108 correct out of 140). Applying thisscoring method to the SSM test, ChatGPT would have scored 105 points in 2021 and 2022, and 100 points in 2023. Conclusions: ChatGPT has exhibited above-average performance in the last three SSM tests, highlighting its robust capability to interpret clinical scenarios and offer precise diagnostic and therapeutic guidance. Despite this, some limitations persist, notably the software's inability to interpret non-textual information.

Preprint ARTICLE | doi:10.20944/preprints202312.0188.v1

Metagenomic of Liver Tissue Identified at Least Two Genera of Totivirus-Like in Molossus molossus Bats

Roseane da Silva Couto, Endrya do Socorro Foro Ramos, Wandercleyson Uchôa Abreu, Luis Reginaldo Ribeiro Rodrigues, Luis Fernando Marinho, Vanessa dos Santos Morais, Fabiola Villanova, Ramendra Pati Pandey, Xutao Deng, Eric Delwart, Antonio Charlys da Costa, Elcio Leal

Subject: Biology And Life Sciences, Virology Keywords: Metagenomics; Totivirus; Bats; Molossus; Amazon region.

Online: 4 December 2023 (15:21:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202303.0264.v1

Train-Your-Brain Program for Informal Caregivers of Stroke Survivors: A Pilot Community-Based Cognitive Intervention Study to Promote Healthy Dietary Behaviors and Social Participation

Xiang Cong Tham, Vanessa Jing Xin Phua, Evelyn Kit Yee Ho, Tingting Yan, Nicole Yun Ching Chen, Mabel Qi He Leow, Xin Yi Seah, Vivien Xi Wu, Wentao Zhou, Edward Wing Hong Poon, Wei Fong Liau, Yanhong Dong

Subject: Social Sciences, Behavior Sciences Keywords: post-stroke; community intervention; stroke survivors; caregivers; diet; fruits; vegetables; social participation

Online: 15 March 2023 (01:47:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202207.0351.v1

Almamy Amara Touré, Aboubacar Sidiki Magassouba, Gnoume Camara, Abdoulaye Doumbouya, Diao Cissé, Ibrahima Barry, Lansana Mady Camara, Abdoul Habib Béavogui, Alexandre Delamou, Vanessa Veronese, Corinne Simone Merle, Hugues Asken Traoré, Adama Marie Bangoura

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Tuberculosis; Health-related quality of life; COVID-19; Guinea

Online: 25 July 2022 (05:37:10 CEST)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202201.0353.v1

GXP: Analyze and Plot Plant Omics Data in Web Browsers

Constantin Eiteneuer, David Velasco, Joseph Atemia, Dan Wang, Andrea Schrader, Roland Pieruschka, Sven Fahrner, Rainer Schwacke, Vanessa Wahl, Ulrich Schurr, Björn Usadel, Asis Hallab

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: RNA sequencing; metabolomics; data visualization; overrepresentation analysis; cluster analysis; principal component analysis; scientific plotting; Mapman; Mercator

Online: 24 January 2022 (12:36:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0341.v1

Feline Calicivirus Virulent Systemic Disease: Clinical Epidemiology, Analysis of Viral Isolates and in vitro Efficacy of Novel Antivirals in Australian Outbreaks

Matteo Bordicchia, Tulio Machado Fumian, Kate Van Brussel, Alice G. Russo, Maura Carrai, Shi-jia Le, Patricia A. Pesavento, Edward C. Holmes, Vito Martella, Peter White, Julia A. Beatty, Mang Shi, Vanessa R. Barrs

Subject: Biology And Life Sciences, Virology Keywords: Caliciviridae; Vesivirus; Nitazoxanide; 2’-C-methylcytidine; NITD-008; cats

Online: 16 August 2021 (13:50:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0080.v1

The Neurological Asymmetry of Self-Face Recognition

Aleksandra Janowska, Brianna Balugas, Matthew Pardillo, Victoria Mistretta, Katherine Chavarria, Janet Brenya, Taylor Shelansky, Vanessa Martinez, Kitty Pagano, Nathira Ahmad, Samantha Zorns, Abigail Straus, Sarah Sierra, Julian Paul Keenan

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Symmetry; Self-Face Recognition; Right Hemisphere; Self-Awareness

Online: 2 April 2021 (18:19:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.0740.v1

NLP-Driven Analysis of Pneumothorax Incidence Following Central Venous Catheter Procedures: A Data-Driven Reevaluation of Routine Imaging in Value-Based Medicine

Martin EM Breitwieser, Vanessa Moore, Teresa Wiesner, Florian Wichlas, Christian Deininger

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: pneumothorax; CVC; central venous catheterization; removal; NLP; natural language processing; machine learning; value-based medicine; cost-effectiveness

Online: 10 October 2024 (10:27:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0080.v1

Chikungunya Infection Increases Osteoclastogenic Genes Ex-pression in Blood and Chronic Arthralgia May Be Related to Enhanced Osteoclast Survival

Alysson Henrique Urbanski, Vanessa Escolano Maso, Felipe de Mello Martins, Andre Guilherme da Costa-Martins, Ana Paula Barbosa do Nascimento Oliveira, Helder I. Nakaya

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Chikungunya fever; Rheumatoid arthritis; RANK signaling; CDR3; B cells; T cells

Online: 2 August 2024 (04:06:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0023.v1

Good Dietary Pattern as a Protective Factor against the Development of Clinical Manifestations in Oropouche Infections in the Amazon Region

Vanessa Carvalho, Raimunda Azevedo, Valéria Carvalho, Pedro Vasconcelos, Lívia Martins

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: arboviruses; Oropouche virus; clinical manifestations; food pattern; protection factor; dietary pattern

Online: 1 April 2024 (10:01:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0330.v1

Host-Pathogen Interactions and Correlated Factors That Are Affected in Replicative-Aged Cryptococcus neoformans

Vanessa K.A. Silva, Sungyun Min, Kyungyoon Yoo, Bettina C. Fries

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Aging; cryptococcosis; G2 arrest; intracellular parasitism; phagosomal pH; polysaccharide capsule; vomocytosis; urease

Online: 6 March 2024 (10:58:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0301.v1

Immunological Response against Breast Lineage Cells Transfected with Human Papillomavirus (HPV)

Daffany Luana dos Santos, Bianca de França São Marcos, Georon Ferreira De Sousa, Leonardo Carvalho de Oliveira Cruz, Bárbara Rafaela da Silva Barros, Mariane Cajuba de Britto Lira Nogueira, Talita Helena de Araújo Oliveira, Anna Jéssica Duarte Silva, Vanessa Emanuelle Pereira Santos, Cristiane Moutinho Lagos De Melo, Antonio Carlos De Freitas

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Keywords: oncogenes; MDA-MB-231; triple-negative.

Online: 4 January 2024 (03:06:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.1531.v1

Effects of Single Nucleotide Polymorphism BsmI of the Vitamin D Receptor (VDR) Gene on VDR, SOD-2, and CYP24A1 Gene Expression in Subjects with Low Serum Vitamin D Levels

Vanessa Rosa Retamoso, Fernanda Barbisan, Graziela Meira Moro, Patricia Maurer, Debora Vasquez Rubio, Lauren Flores Vieira Dos Santos, Lyana Berro Feijóo, Matias Nunes Frizzo, Ivana Beatrice Mânica Da Cruz, Vanusa Manfredini, Ana Leticia Vargas Barcelos, Jacqueline da Costa Escobar Piccoli

Subject: Public Health And Healthcare, Other Keywords: vitamin D; hypovitaminosis; Cytochorme P 450 (CYP); SOD2

Online: 21 July 2023 (13:21:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0165.v1

Bacillus aryabhattai Mitigates the Effects of Salt and Water Stress on the Agronomic Performance of Maize Under an Agroe-Cological System

Henderson Castelo Sousa, Geocleber Gomes de Sousa, Thales Vinícius De Araújo Viana, Arthur Prudêncio de Araújo Pereira, Carla Ingryd Nojosa Lessa, Maria Vanessa Pires de Souza, José Marcelo Da Silva Guilherme, Geovana Ferreira Goes, Francisco Gleyson Da Silveira Alves, Silas Primola Gomes, Fred Denilson Barbosa da Silva

Subject: Environmental And Earth Sciences, Other Keywords: Zea Mays; abiotic stress; microorganisms; salinity; water deficit

Online: 10 April 2023 (10:15:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0491.v1

Autonomic Function Recovery in Post-Covid-19 Young Adults After Immunization: An Observational Follow up Case-control Study

Ana Paula Coelho Figueira Freire, Shaan Amin, Fabio Santos Lira, Ana Elisa von Ah Morano, Telmo Pereira, Manuel J. Coelho-e-Silva, Armando Caseiro, Diego Giulliano Destro Christofaro, Vanessa Ribeiro-Santos, Osmar Marchioto Júnior, Ricardo A Pinho, Bruna Spolador de Alencar Silva

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: COVID-19; SARS-CoV-2; exercise; autonomic nervous system; sympathetic nervous system; parasympathetic nervous system; COVID-19 vaccination; post-acute sequelae of COVID-19; communicable diseases

Online: 28 November 2022 (03:39:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202410.0824.v1

Bioactivity, Efficacy, and Safety of a Wound Healing Ointment with Medicinal Plant Bioactives: In Vitro and In Vivo Preclinical Evaluations

Juliana Floriano, Daniel Rodrigues, Rie Ohara, Nara Almeida, Vanessa Soares, Patricia Sartorelli, Carlos Graeff, Simone Grecco, Alejandra González, Paulo D'Alpino

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: chronic wounds; wound care; natural compounds; biocompatibility; pre-clinical tests

Online: 10 October 2024 (12:59:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1248.v1

Antifungal Activity of Citrus Essential Oil in Controlling Sour Rot in Tahiti Acid Lime Fruits

Vanessa Santos Moura, Lara Dias Orlandin, Beatriz Saraiva Mariano, Josiane Rodrigues, Fernando Trevizan Devite, FERNANDO ALVES DE AZEVEDO, Marines Bastianel

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: natural fungicides; post-harvest; biocontrol; agricultural sutainaibility

Online: 16 September 2024 (14:35:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.1416.v1

Vascular Diseases In Women. Do women suffer from them differently?

Katalin Farkas, Agata Stanek, Stephanie Zbinden, Barbara Borea, Simina Ciurica, Vanessa Moore, Peggy Maguire, Maria Teresa B. Abola, Elaine B Alajar, Antonella Marcoccia, Dilek Erer, Ana I. Casanegra, Hiva Sharebiani, Muriel Sprynger, Maryam Kavousi, Mariella Catalano

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Women; Vascular diseases; Risk factors; Gender differences

Online: 18 January 2024 (12:31:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1854.v1

SISA: The First Extreme-Ultraviolet Solar Integral Field Spectrograph Using Slicers

Ariadna Calcines Rosario, Hamish Andrew Sinclair Reid, Sarah Matthews, Frédéric Auchère, Alain Jody Corso, Giulio Del Zanna, Jaroslav Dudik, Samuel Gissot, Laura Hayes, Graham Stewart Kerr, Christian Kintziger, Sophie Musset, Vanessa Polito, Daniel F. Ryan, David Orozco Suárez

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: EUV Spectroscopy; solar IFS; EUV slicers; image slicers; solar space mission; particle acceleration

Online: 29 November 2023 (10:56:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202208.0181.v1

Blood Leukocyte Transcriptional Modules and Differentially Expressed Genes Associated with Disease Severity and Age in COVID-19 Patients

Silvia Yumi Bando, Fernanda Bernardi Bertonha, Sandra E Vieira, Danielle B. L. Oliveira, Vanessa N Chalup, Edison L Durigon, Patricia Palmeira, Ana Cristina P Curi, Caroline S Faria, Leila Antonangelo, Gerhard da P Lauterbach, Fabiane A Regalio, Roberto M Cesar Jr, Carlos Alberto Moreira-Filho

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; SARS-CoV-2; disease severity; blood leukocyte transcriptome; WGCNA; transcriptional modules; differentially expressed genes; COVID-19 transcriptional markers

Online: 9 August 2022 (14:59:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0290.v3

Epigenetic Modulation of Gremlin-1/NOTCH Pathway in Experimental Crescentic Immune-Mediated Glomerulonephritis

Lucia Tejedor-Santamaria, Jose Luis Morgado-Pascual, Laura Marquez-Exposito, Beatriz Suarez-Alvarez, Raul R. Rodrigues-Diez, Antonio Tejera-Muñoz, Vanessa Marchant, Sergio Mezzano, Carlos López-Larrea, Anna Sola, Gema Maria Fernandez-Juarez, Alberto Ortiz, Sandra Rayego-Mateos, Marta Ruiz-Ortega

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: crescentic glomerulonephritis; BET proteins; NOTCH; GREMLIN; Chronic kidney disease; Bromodomain

Online: 23 December 2021 (14:40:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.2004.v1

Dogs as Sentinels for Emergent Pathogens: Serological Evidence in a Preserved Area in Brazil

Liliane Silva Durães, Ana Íris Duré, Gislene Fournier, Vanessa Miranda Reis, Graziela Tolescano-Pascoli, Diego Ramirez, Miriam Tsunemi, Lucas Belchior Souza de Oliveira, Lee Fuller

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Rickettsia spp.; Ehrlichia canis; Anaplasma phagocytophilum; human; epidemiological surveillance; public health.; dogs; sentinel; sentinel host

Online: 28 June 2024 (05:04:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1976.v1

Anatomical and Imaging Aspects of the Hip Joint of the Giant Anteater (Myrmecophaga tridactyla)

Carolina Castro Lyra da Silva, Júlio Roquete Cardoso, Daniel Barbosa da Silva, Wanessa Patrícia Rodrigues da Silva, Lucas Rodrigues Ferreira, Vanessa Rezende Moraes, Rafael Antônio Lopes Xavier, Murilo Rodrigues de Souza, Naida Cristina Borges

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: wild animals, gross anatomy, radiography, ultrasound, giant anteater

Online: 30 April 2024 (11:58:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1166.v1

E7 Oncogene HPV 58 Variants Detected in Northeast Brazil: Genetic and Functional Analysis

Bárbara Simas Chagas, Elias Tibúrcio-Júnior, Ruany Cristyne de Oliveira Silva, Daffany Luana dos Santos, Marconi Rêgo Barros-Júnior, Rita de Cássia Pereira de Lima, Maria da Conceição Viana Invenção, Pedro Luiz França Neto, Vanessa Emanuelle Pereira Santos, Antonio Hunberto Silva-Júnior, Jacinto Costa Silva-Neto, Marcus Vinícius de Aragão Batista, Antonio Carlos de Freitas

Subject: Biology And Life Sciences, Virology Keywords: human papillomavirus 58; E7 oncogene; variants; phylogenetic analysis; gene expression

Online: 16 June 2023 (10:01:35 CEST)

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Working Paper ARTICLE

A Novel Threat-Abatement Framework Confirms an Urgent Need to Limit Habitat Loss and Improve Management of Invasive Species and Inappropriate Fire Regimes for Australia’s Threatened Species

Stephen G. Kearney, James E. M. Watson, April E. Reside, Diana O. Fisher, Martine Maron, Tim S. Doherty, Sarah M. Legge, John C. Z. Woinarski, Stephen T. Garnett, Brendan A. Wintle, Euan G. Ritchie, Don A. Driscoll, David Lindenmayer, Vanessa M. Adams, Michelle S. Ward, Josie Carwardine

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Biodiversity; Conservation; Extinction; Threat management; Habitat retention; Protected Areas.

Online: 19 October 2020 (11:08:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202008.0020.v1

SARS-CoV-2 and Covid-19 Immunopathogenesis

Antonio Luiz Boechat, Beatriz Pessoa, Carlos Soares, Cecília Barroso, David Vila, Emanuelly Barbosa, Isabela Seffair, João Victor Melo, Julia Becil, Maria Polyanna Rebouças, Natascha Rodrigues, Pedro Henrique Freitas, Rebeka Rocha, Thaise Rodrigues, Vanessa Ferreira, Rosmery Ubiera, Maria Cristina Dos-Santos

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: SARS-CoV-2; COVID-19; Immunopathogenesis; Cytokine storm; IL-6; macrophages; neutrophils

Online: 2 August 2020 (11:53:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.0224.v1

Developments in the Use of Indocyanine Green (ICG) Fluorescence in Colorectal Surgery

Shayan Khalafi, Cristina Botero Fonnegra, Ana Reyes, Vanessa W Hui

Subject: Medicine And Pharmacology, Surgery Keywords: Indocyanine Green; colorectal cancer; tumor marking; lymphatic mapping; colorectal anastomosis

Online: 5 June 2024 (09:37:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1688.v1

Title Impact of Exogenous Lactobacillus plantarum on the Gut Microbiome of Hematopoietic Stem Cell Transplantation Patients Colonized by Multi-Drug Resistant Bacteria

Bruna D.G.C. Moraes, Roberta CR Martins, Joyce Vanessa da Silva Fonseca, Lucas AM Franco, Gaspar CO Pereira, Thaisi F Bartelli, Marina F Cortes, Carolina F Santos, Priscila T Musqueira, Leonardo J Otuyama, Victor S. Pylro, Livia Mariano, Vanderson Rocha, Steven S Witkin, Ester C Sabino, Thais Guimaraes, Silvia F Costa

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: L. plantarum; Microbiome, MDRO colonization

Online: 27 November 2023 (11:32:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0250.v1

Low Prevalence of SARS-CoV-2 Antibodies in Canine and Feline Serum Samples Collected during the Covid-19 Pandemic in Hong Kong and Korea

Yun Young Go, Maura Carrai, Yan Ru Choi, Christopher J. Brackman, Karina W.S. Tam, Pierra Y.T. Law, Fiona Woodhouse, Jane Gray, Ji Hun Kim, Joohyung Park, Chae Won Jeon, Hyomi Jang, Ioannis Magouras, Nicola Decaro, Samuel MS Cheng, Malik Peiris, Julia A. Beatty, Vanessa R. Barrs

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; COVID-19; Feline; Canine; seroprevalence; zoonosis

Online: 13 January 2023 (10:21:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0222.v1

Correlation Between Vascular Inflammation Markers, Diastolic Dysfunction and Cardiovascular Risk in Patients with Takayasu Arteritis

Sebastiano Cicco, Vanessa Desantis, Antonio Vacca, Gerardo Cazzato, Antonio Giovanni Solimando, Anna Lisa Cirulli, Silvia Noviello, Cecilia Susca, Marcella Prete, Gabriele Brosolo, Cristiana Catena, Aurelia Lamanuzzi, Ilaria Saltarella, Maria Antonia Frassanito, Antonietta Cimmino, Giuseppe Ingravallo, Leonardo Resta, Roberto Ria, Monica Montagnani

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Takayasu arteritis; echocardiography; immune cell infiltration; vascular stiffness; T helper like cells; regulatory T lymphocytes

Online: 12 November 2021 (13:40:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0645.v1

Can a single trial of a thoracolumbar myofascial release technique reduce pain and disability in chronic low back pain? Randomized balanced cross-over study

Luana Rocha Paulo, Ana Cristina Rodrigues Lacerda, Fábio Luiz Mendonça Martins, José Sebastião Cunha Fernandes, Leonardo Sette Vieira, Cristiano Queiroz Guimarães, Sílvia de Simoni Guedes Ballesteros, Marco Túlio Saldanha dos Anjos, Patrícia Aparecida Tavares, Sueli Ferreira da Fonseca, Murilo Xavier Oliveira, Mário Bernardo-Filho, Danúbia da Cunha de Sá-Caputo, Vanessa Amaral Mendonça, Redha Taiar

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: fascia; chronic low back pain; myofascial release

Online: 25 March 2021 (16:24:46 CET)

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Preprint REVIEW | doi:10.20944/preprints201906.0145.v1

High-Risk Multiple Myeloma: Integrated Clinical and Omics Approach Dissects the Neoplastic Clone and the Tumor Microenvironment

Antonio Giovanni Solimando, Matteo Claudio Da Vià, Sebastiano Cicco, Patrizia Leone, Giuseppe Di Lernia, Donato Giannico, Vanessa Desantis, Maria Antonia Frassanito, Arcangelo Morizio, Julia Delgado Tascon, Giuseppe Ranieri, Roberto Ria, Leo Rasche, K. Martin Kortüm, Andreas Beilhack, Vito Racanelli, Angelo Vacca, Hermann Einsele

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: multiple myeloma; angiogenesis; extramedullary disease; drug resistance; bone marrow microenvironment.

Online: 16 June 2019 (10:05:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints201708.0076.v1

30 Years of Research on Crown-of-thorns Starfish (1986-2016): Scientific Advances and Emerging Opportunities

Morgan S. Pratchett, Ciemon F. Caballes, Jennifer C. Wilmes, Samuel Matthews, Camille Mellin, Hugh P.A. Sweatman, Lauren E. Nadler, Jon Brodie, Cassandra A. Thompson, Jessica Hoey, Arthur R. Bos, Maria Byrne, Vanessa Messmer, Sofia Valero-Fortunato, Carla C.M. Chen, Alexander C.E. Buck, Russell C. Babcock, Sven Uthicke

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Acanthaster; coral reefs, disturbance; management; population outbreaks; research priorities

Online: 22 August 2017 (10:20:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1074.v1

Socio-Demographic Factors, Behaviors, Motivations, and Attitudes in Food Waste Management of Romanian Households

Elena Morosan, Adriana Maria Dărăban, Violeta Popovici, Andreea Rusu, Elena Iuliana Ilie, Monica Licu, Oana Karampelas, Dumitru Lupuliasa, Emma Adriana Ozon, Vanessa-Maria Maravela, Ioana Andreea Popescu

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: household food waste; food purchase behavior; home food cooking; food waste frequency; homemade food waste; food waste interest; food waste awareness

Online: 14 August 2024 (12:47:06 CEST)

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(1) Background: Food waste (FW) in Romania is 70 Kg/capita/year, while 70% of food waste comes from public catering, retail services, and households (over 50% – 47 million tons). (2) Methods: A cross-sectional observational study was conducted using an online questionnaire via the Google Forms platform from 15 April 2023 to 15 May 2023. The questionnaire was designed to assess various aspects, such as some socio-demographic information (age, sex, occupation, area of residence, study level, household members number, children < 18 years of age); the personal involvement and frequency of food purchases and homemade food cooking; the main sources that generate food waste; the motivation and frequency with which food waste occurs; the level of awareness regarding the impact of food waste; the respondents' intentions regarding sustainable behaviors and practices food management; the level of information and familiarity of the respondents with the notions of validity and how these may influence their food consumption decisions. (3) The results show that FW incidence is occasionally (42%), very rarely (43.33%), frequently (15%), and no food waste was reported by 2.66% of respondents. The [35-44] age category records the highest FW frequency, followed by [18-24]. The most wasted are homemade food (29.67%), bread and bakery products (27.00%), and fruits and vegetables (14.33%). High involvement in purchasing and buying food following a previously established list reduces FW frequency. The same is valid for high daily involvement in food and homemade cooking. High interest in the FW problem and its perception as a waste of money leads to diminishing it, while guilty feelings increase the FW level (37.50% to 73.33%). (4) Conclusions: The present study shows that household food waste management is a multifactorial process that involves numerous socio-demographic, behavioral, and emotional aspects. Extensive data analysis supports our results, revealing deep self-reported information details and confirming its complex approach.

Preprint ARTICLE | doi:10.20944/preprints202406.0216.v1

Crystallinity of Halogen-Free Flame-Retardant Polyolefin Compounds Loaded with Natural Magnesium Hydroxide

Vanessa Matteucci, Michela Meucci, Sara Haveriku, Camillo Cardelli, Andrea Pucci

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: crystallinity; halogen-free flame-retardant (HFFR) compounds; LSZH LS0H composites; ethylene-octene copolymers; linear low-density polyethylene (LLDPE); blends; natural magnesium hydroxide (n-MDH); mechanical properties; maleic anhydride grafted polymers; coupling agents

Online: 4 June 2024 (15:15:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0350.v1

Bifidobacterium Species Colonization in Infancy: A Global Cross-Sectional Comparison by Population History of BreastFeeding

Diana H. Taft, Zachery T. Lewis, Nhu Nguyen, Steve Ho, Chad Masarweh, Vanessa Dunne-Castagna, Daniel J. Tancredi, M Nazmul Huda, Charles B. Stephensen, Katie Hinde, Erika von Mutius, Pirkka Kirjavainen, Jean-Charles Dalphin, Roger Lauener, Josef Riedler, Jennifer T. Smilowitz, J. Bruce German, Ardythe L. Morrow, David A. Mills

Subject: Biology And Life Sciences, Food Science And Technology Keywords: infant; breastfeeding; gut microbiome; Bifidobacterium

Online: 28 February 2022 (08:53:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202410.0418.v1

The MARVIN Hypothesis: Linking Unhealthy Lifestyles to Intracranial Aneurysm Rupture Risk and Clinical Prognosis

Vanessa M. Swiatek, Igor Fischer, Rajiv Khajuria, Amir Amini, Hannah Steinkusch, Ali Rashidi, Klaus-Peter Stein, Claudia A. Dumitru, I. Erol Sandalcioglu, Belal Neyazi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Lifestyle-related Risk Factors; Intracranial Aneurysms; Subarachnoid Hemorrhage; Prevention; Rupture Risk Assessment

Online: 7 October 2024 (08:01:11 CEST)

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Background and Objectives: The rising incidence of modifiable lifestyle risk factors and cardiovascular diseases, driven by poor diet, inactivity, excessive alcohol use, and smoking, may influence the development and rupture of intracranial aneurysms (IA). This study aimed to examine the impact of lifestyle-related and cardiovascular risk factors on IA rupture and patient outcomes. Materials and Methods: We developed the "MARVIN" (Metabolic and Adverse Risk Factors and Vices Influencing Intracranial Aneurysms) model and conducted a retrospective analysis of 303 patients with 517 IAs, treated between 2007 and 2020. Of these, 225 patients were analyzed for rupture status and 221 for clinical outcomes. The analysis focused on hypertension, diabetes, hypercholesterolemia, vascular diseases, nicotine and alcohol abuse, obesity, aneurysm rupture status, and clinical outcomes. Logistic regression was used to evaluate the impact of these risk factors. Results: Among those with risk factors, 24.9% (56/225) and 25.3% (56/221) had one, 32.0% (72/225) and 30.8% (68/221) had two, 20.0% (45/225) and 20.4% (45/221) had three, 12.0% (27/225) and 12.2% (27/221) had four, 4.0% (9/225) and 4.1% (9/221) had five, 0.9% (2/225) had six in both groups, and 0.4% (1/225) and 0.5% (1/221) had seven risk factors, respectively. Strong relationships were found between lifestyle-related vascular risk factors, indicating multiple comorbidities in patients with unhealthy habits. Smokers with ruptured aneurysms had higher WFNS (World Federation of Neurosurgical Societies) scores, but nicotine abuse did not affect long-term outcomes. The most significant predictors for poor outcomes were WFNS score and age, while age and a history of vascular diseases were protective against rupture. Despite the high prevalence of modifiable risk factors, they did not significantly influence rupture risk. Conclusions: The findings suggest a need for multifactorial risk assessment strategies in managing IA patients. Future studies with larger cohorts are required to confirm these results and better understand IA progression.

Preprint ARTICLE | doi:10.20944/preprints202404.1390.v1

Suppression PCR-Based Selective Enrichment Sequencing for Pathogen and Antimicrobial Resistance Detection on Cell-Free DNA in Sepsis - A Targeted, Blood Culture Independent Approach for Rapid Pathogen and Resistance Diagnostics in Septic Patients

Mirko Sonntag, Vanessa K. Elgeti, Yevhen Vainshtein, Lucca Jenner, Jan Mueller, Thorsten Brenner, Sebastian O. Decker, Kai Sohn

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: sepsis; antimicrobial resistances; cell-free DNA; precision diagnostics; Next-Generation sequencing; suppression PCR; real-time diagnostics; nanopore sequencing

Online: 22 April 2024 (10:13:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202402.1573.v1

Advancing Agricultural Sustainability in Tropical Climates: Harnessing the Potential of Green Manuring

Fábio Cunha Coelho, Claudia Lopes Prins, Jaídson Gonçalves da Gonçalves da Rocha, Vanessa Pereira de Jesus, Nathália Souza Teixeira, Priscila Pixoline Eiras, Amilly Santos Vaz

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: agroecology; intercropping; legumes; nitrogen cycles; organic matter; organic farming

Online: 27 February 2024 (15:41:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0261.v1

A Comparative Analysis of Human Hepatic Lesions in Dengue, Yellow Fever, and Chikungunya: Revisiting Histopathological Changes in the Light of Modern Knowledge of Cell Pathology

Yasmin Ribeiro, Luiz Fábio Magno Falcão, Vanessa Cavaleiro Smith, Jorge Rodrigues Sousa, Carla Pagliari, Edna Cristina dos Santos Franco, Ana Cecília Ribeiro Cruz, Jannifer O. Chiang, Lívia Caricio Martins, Juliana Abreu Lima Nunes, Felipe Souza da Silva Vilacoert, Lais Carneiro dos Santos, Matheus Perini Furlaneto, Hellen Thaís Fuzii, Marcos Virgilio Bertonsin Filho, Luccas Delgado Da Costa, Maria Irma Seixas Duarte, Ismari Perini Furlaneto, Arnaldo Jorge Martins-Filho, Tinara Aarão, Pedro F.C. Vasconcelos, Juarez Antônio Simões Quaresma

Subject: Biology And Life Sciences, Virology Keywords: Arboviruses; Histopathology; Cell death; Necrosis; Steatosis; Liver

Online: 16 January 2023 (02:55:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0275.v1

Vaccination with Formulation of Nanoparticles Loaded with Leishmania amazonensis Antigens Confers Protection against Experimental Visceral Leishmaniasis in Hamster

Marco Antonio Cabrera González, Ana Alice Maia Gonçalves, Jennifer Ottino, Jaqueline Costa Leite, Lucilene Aparecida Resende, Otoni Alves Melo-Júnior, Patrícia Silveira, Mariana Santos Cardoso, Ricardo T. Fujiwara, Lilian Bueno, Renato Lima Santos, Tatiane Furtado de Carvalho, GIANI MARTINS GARCIA, Paulo Ricardo de Oliveira Paes, Alexsandro Sobreira Galdino, Miguel Angel Chávez-Fumagalli, Marília Martins, Denise da Silveira-Lemos, Olindo Assis Martins-Filho, Walderez Ornelas Dutra, Vanessa Mosqueira, Rodolfo Cordeiro Giunchetti

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: visceral leishmaniasis; nanotechnology; vaccine

Online: 15 November 2022 (06:15:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0896.v1

Nutritional Screening and Assessment in Mexican Outpatient Cancer Patients

Gabino Cervantes-Guevara, Karla Veronica Chavez, Blanca Ernestina Vazquez-Lopez, Zayda Vanessa Herrera-Ponce, Lisset Citlali Magaña-de la Vega, Clotilde Fuentes-Orozco, Alejandro Gonzalez-Ojeda, Diana Mercedes Hernandez-Corona, Tonatiuh Gonzalez-Heredia, Miriam Méndez-del Villar, Fernada Isadora Corona-Meraz, Milton Omar Guzman-Ornelas, Linda Paola Gomez-Cabral, Jose Alberto Gonzalez-Duarte, Fernanda Monserrat Rendon-Serrano, Mariana Chavez-Tostado

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: malnutrition; cancer; GLIM criteria; PG-SGA; NRS-200; MUST; MST; nutriscore

Online: 12 September 2024 (10:57:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201704.0179.v1

Effects of Hydroalcoholic Extract of Celtis iguanaea on Markers of Cardiovascular Diseases and Glucose Metabolism in Cholesterol-Fed Rats

Barbara Zanchet, Denise B. Gomes, Vanessa S. Corralo, Kriptsan A. P. Diel, Amanda P. Schönell, Caroline Faust, Patrícia Nicola, Liz G. Muller, Ana Paula Zanatta, Silvana M. Wildner, Fernanda Bevilaqua, Rafael Chitolina, Adrieli Sachett, Leila Zanatta, Marta M. M. F. Duarte, Greicy M. M. Conterato, Claudia Q. Rocha, Camile Peretti, Tatiane Brumelhaus, Nayara Souza Alves, Jean Carlo Olivo Menegatt, Fernanda Conte, Guilherme Serena, Adriano Tony Ramos, Francielli Cordeiro Zimermann, Walter A. Roman Junior

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: medicinal plants; flavonoids; hypoglycemic; hypolipidemic; antiatherogenic

Online: 27 April 2017 (04:13:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1535.v1

Analysis of MLKL, RIP1, and RIP3 Immunostaining Markers in Human Liver Tissue from Fatal Yellow Fever Cases: Insights into Necroptosis

Vanessa do Socorro Cabral Miranda, Luiz Fabio Magno Falcao, Jeferson da Costa Lopes, Hellen Thais Fuzii, Marcos Luiz Gaia Carvalho, Arnaldo Jorge Martins Filho, Ana Cecilia Ribeiro Cruz, Raimunda S. S. Azevedo, Jorge R. Sousa, Mayumi Duarte Wakimoto, Pedro Fernando da Costa Vasconcelos, Juarez Antônio Simões Quaresma

Subject: Medicine And Pharmacology, Tropical Medicine Keywords: Yellow Fever; Necroptosis; liver parenchyma

Online: 22 August 2024 (05:53:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1704.v1

Antivirals for Yellow Fever: Bioassay-Guided Fractionation of Hippeastrum puniceum Bulb Extract with Inhibitory Activity against Wild-Type Yellow Fever Virus and In Silico ADMET Prediction of the Annotated Natural Compounds

Eliza Flores-Souza, Alisson Samuel Portes Caldeira, Carolina Colombelli Pacca Mazaro, Tamiris Vanessa Miguel-de Souza, Thaís M. Acácio, Emerson de Castro Barbosa, Douglas Eduardo Valente Pires, Naiara Clemente Tavares, Carlos Eduardo Calzavara-Silva, Carlos Leomar Zani, Jaquelline Germano de Oliveira, Tania Maria Almeida Alves

Subject: Biology And Life Sciences, Virology Keywords: antivirals; wild-type yellow fever virus; Hippeastrum puniceum; natural compound, bioassay-guided fractionation; UHPLC-HRMS/MS; In silico ADMET prediction

Online: 22 July 2024 (11:56:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1395.v1

Risk Awareness as a Key Determinant of Early Vaccine Uptake in the Mpox Vaccination Campaign in an Italian Region: A Cross-Sectional Analysis

Giulia Del Duca, Alessandro Tavelli, Ilaria Mastrorosa, Camilla Aguglia, Simone Lanini, Anna Clelia Brita, Roberta Gagliardini, Serena Vita, Alessandra Vergori, Jessica Paulicelli, Giorgia Natalini, Angela D'Urso, Pierluca Piselli, Paola Gallì, Vanessa Mondillo, Claudio Mastroianni, Enrica Tamburrini, Loredana Sarmati, Cristof Stingone, Miriam Lichtner, Emanuele Nicastri, Massimo Farinella, Filippo Leserri, Andrea Siddu, Francesco Maggi, Antonella D'Arminio Monforte, Francesco Vairo, Alessandra Barca, Francesco Vaia, Enrico Girardi, Valentina Mazzotta, Andrea Antinori

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Mpox infection; mpox vaccination; risk awareness, vaccine acceptance; vaccine hesitancy; health-related quality of life; the Short-Form 36-item questionnaire

Online: 24 October 2023 (07:56:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.1321.v1

From Traditionally Extensive to Sustainably Intensive: A Review on the Path to a Sustainable and Inclusive Beef Farming in Brazil

Mariana A. Pereira, Davi J. Bungenstab, Valéria P. B. Euclides, Guilherme C. Malafaia, Paulo H. N. Biscola, Gilberto R. O. Menezes, Urbano G. P. Abreu, Valdemir A. Laura, Ériklis Nogueira, Rodiney de A. Mauro, Marta P. da Silva, Alessandra C. Nicacio, Roberto G. de Almeida, Rodrigo da C. Gomes, Juliana C. B. Silva, Vanessa F. de Souza

Subject: Biology And Life Sciences, Other Keywords: beef farming; Brazil; sustainable intensification; public policies

Online: 19 June 2024 (07:34:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.0538.v1

Rowing Against the Tide: The Golden Mussel (Limnoperna fortunei) Leaves DNA Footprints Along Its Invasion Route in South American Rivers

Augusto Luiz Ferreira-Jr, Renato Luiz Bot Neto, Vanessa Marin-Ruiz, Leonardo Cruz da Rosa, Mara C. Almeida, Patricia D. Borges, Susete W. Christo, Roberto Ferreira Artoni

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: bioinvasion; exotic invasive species; watersheds; human facilitation; intercontinental dispersal; bridgehead effects; mitochondrial DNA signatures; invasion genetics; gene flow

Online: 8 October 2024 (10:21:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0241.v1

Epidemiological and Clinical Features of SARS-CoV-2 Variants Circulating between April-December 2021 in Italy

Alessia Lai, Annalisa Bergna, Carla Della Ventura, Stefano Menzo, Bianca Bruzzone, Fabio Sagradi, Francesca Ceccherini-Silberstein, Alessandro Weisz, Nicola Clementi, Gaetano Brindicci, Ilaria Vicenti, Lolita Sasset, Sara Caucci, Benedetta Corvaro, Silvia Ippoliti, Carla Acciarri, Vanessa De Pace, Leonardo Lanfranchi, Maria Concetta Bellocchi, Giorgio Giurato, Roberto Ferrarese, Antonella Lagioia, Daniela Francisci, Martina Laura Colombo, Samuel Lazzarin, Matilde Ogliastro, Maria Rosa Cappelletti, Marco Iannetta, Francesca Rizzo, Carmen Rita Santoro, Chiara Fraccalvieri, Sophie Testa, Luca Carioti, Teresa Rocco, Annalisa Saracino, Annamaria Cattelan, Massimo Clementi, Loredana Sarmati, Agostino Riva, Spinello Antinori, Gianguglielmo Zehender

Subject: Biology And Life Sciences, Virology Keywords: variants circulation; SARS-CoV-2; Italy; epidemiology

Online: 16 September 2022 (08:07:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0549.v1

Advanced Quantification of Receptor–Ligand Interaction Lifetimes via Single-Molecule FRET Microscopy

Lukas Schrangl, Vanessa Mühlgrabner, René Platzer, Florian Kellner, Josephine Wieland, Reinhard Obst, Jose L. Toca-Herrera, Johannes B. Huppa, Gerhard J. Schütz, Janett Göhring

Subject: Biology And Life Sciences, Biophysics Keywords: single-molecule FRET; single-molecule microscopy; receptor-ligand interaction; T cell receptor; bond lifetime quantification; T cell activation; antigen sensitivity; simulation; survival analysis

Online: 9 July 2024 (03:56:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1812.v1

A Mini-Review on Diagnostic Methods for Antigen and Antibody Detection of Rocky Mountain and Brazilian Spotted Fever

Kamila Alves Silva, Vanessa Borges Prado, Rafael Rodrigues Silva, Marcelo Van Petten Rocha, Rafael Almeida Ribeiro de Oliveira, Tarumim de Jesus Rodrigues Falcão, Clara Cristina Serpa, Marina Andrade Rocha, Sabrina Paula Pereira, Liria Souza Silva, Juliana Martins Machado, Ricardo Andrez Machado-de-Ávila, Ricardo Toshio Fujiwara, Miguel Angel Chavez Fumagalli, Eduardo Antonio Ferraz Coelho, Rodolfo Cordeiro Giunchetti, Mariana Campos-da-Paz, Ana Alice Maia Gonçalves, Alexsandro Sobreira Galdino

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Rickettsia rickettsii; Rocky Mountain spotted fever; Brazilian spotted fever; diagnosis

Online: 28 April 2024 (04:59:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1734.v1

Differential miRNA and Protein Expression Reveals miR-1285, Its Targets TGM2 and CDH-1 as Well as CD166 and S100A13 as Potential New Biomarkers in Patients with Diabetes Mellitus and Pancreatic Adenocarcinoma

Theodoros Kolokotronis, Britta Majchrzak-Stiller, Marie Buchholz, Vanessa Mense, Johanna Strotmann, Ilka Peters, Lea Skrzypczyk, Sven-Thorsten Liffers, Louise Massia, Mathias Wagner, Matthias Glanemann, Fay Betsou, Wim Ammerlaan, Ronny Schmidt, Christoph Schröder, Waldemar Uhl, Chris Braumann, Philipp Hohn

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: pancreatic adenocarcinoma; biomarkers; diabetes mellitus; S100A13; miR-1285

Online: 25 June 2024 (09:25:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0169.v1

A Longitudinal Approach to Biological Psychiatric Research: The PsyCourse Study

Monika Budde, Heike Anderson-Schmidt, Katrin Gade, Daniela Reich-Erkelenz, Kristina Adorjan, Janos L. Kalman, Fanny Senner, Sergi Papiol, Till F. M. Andlauer, Ashley L. Comes, Eva C. Schulte, Farah Klöhn-Saghatolislam , Anna Gryaznova, Maria Hake, Kim Bartholdi, Laura Flatau, Markus Reitt, Silke Quast, Sophia Stegmaier, Milena Meyers, Barbara Emons, Ida Sybille Haußleiter, Georg Juckel, Vanessa Nieratschker, Udo Dannlowski, Max Schmauß, Jörg Zimmermann, Jens Reimer, Sybille Schulz, Jens Wiltfang, Eva Reininghaus, Ion-George Anghelescu, Volker Arolt, Bernhard T. Baune, Carsten Konrad, Andreas Thiel, Andreas J. Fallgatter, Christian Figge, Martin von Hagen, Manfred Koller, Fabian U. Lang, Moritz E. Wigand, Thomas Becker, Markus Jäger, Detlef E. Dietrich, Sebastian Stierl, Harald Scherk, Carsten Spitzer, Here Folkerts, Stephanie H. Witt, Franziska Degenhardt, Andreas J. Forstner, Marcella Rietschel, Markus M. Nöthen, Peter Falkai, Thomas G. Schulze, Urs Heilbronner

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Schizophrenia; bipolar; psychosis; depression; polygenic risk score; diagnosis; RDoC

Online: 27 October 2017 (11:58:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0111.v1

Predictors of Hospitalization in Breakthrough COVID-19 among Fully Vaccinated Individuals with Immune-Mediated Rheumatic Diseases: Data from Safer-Study

Debora Cerqueira Calderaro, Valéria Valim, Gilda Ferreira Oliveira, Ketty Lysie Libardi Lira Machado, Priscila Dias Cardoso Ribeiro, Sandra Lúcia Euzébio Ribeiro, Natália Sarzi Sartori, Rodrigo Poubel Vieira Rezende, Ana Karla Guedes Melo, Vitor Cruz, Adah Sophia Rodrigues Vieira, Adriana Maria Kakehasi, Aline Teixeira Landa, Ana Paula Neves Burian, Flávia Maria Matos Melo Campos Peixoto, Camila Maria Paiva França Telles, Rafaela Cavalheiro do Espírito Santo, Katia Lino Baptista, Yasmin Gurtler Pinheiro Oliveira, Vanessa de Oliveira Magalhães, Raquel Lima Lima, Erika Biegelmeyer, Pietra Zava Lorencini, Andréa Teixeira-Carvalho, Edgard Torres Reis-Neto, Emilia Inoue Sato, Marcelo Medeiros Pinheiro, Odirlei André André Monticielo, Viviane Angellina de Souza, Ricardo Machado Xavier, Gecilmara Salviato Pileggi

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: COVID-19; COVID-19 vaccines; health disparities; breakthrough COVID-19 infections; rheumatic diseases; vaccination of immune compromised patients; COVID-19 vaccine booster shot

Online: 2 August 2024 (09:08:01 CEST)

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