Maintaining an adequate micronutrient status can be achieved by following a complete, diverse diet. Yet, food trends in Western countries show suboptimal consumption of healthy nutrients. In this study we explored the prevalence of vitamin and mineral imbalances in a general population cohort of Dutch adults, and evaluated the effect of a digital lifestyle program on the nutritional status and nutrition health behaviors of these individuals. A micronutrient panel was measured in 348 participants, alongside a dietary assessment. One-hundred users subsequently underwent a remeasurement. We identified at least one nutritional imbalance in 301 individuals (86.5%). 80% improved and normalized B6, 67% improved folate, 70% improved B12, and 86% improved vitamin D. Iron abnormalities were corrected in 75% of participants. In conclusion, this study found micronutrient deficiencies of easily obtainable vitamins through diet or supplementation such as B vitamins and vitamin D were more prevalent than expected in a Dutch population. This can partly be explained by an insufficient consumption of food groups rich in B vita-mins. Our preliminary results in those remeasured after a digitally-enabled lifestyle intervention show these imbalances can be corrected with adequate behavioral support in a “food as medicine” approach complemented with supplementation where needed.

This paper explores the coordination of the agricultural cooperative to supermarket or E-commerce sup-ply chain, under the condition of quantity loss with a mixed decay function of exponential and logistical distribution. The nature of this process is analyzed, and the corresponding demand and supply functions with single- and multi-stage discount strategies are constructed respectively to create a working model. The optimal discount ratios for supermarkets and agricultural cooperatives in decentralized and central-ized decision-making modes coupled with single- and multi-stage discounts are calculated respectively. Finally, a universal optimal strategy is designed, which can be applied to various quantity decay scenarios and makes the discount strategy more generalized. The results show that discounts can coordinate supply chains more effectively; not only is fresh agricultural produce sold before it starts to rot, but the benefit conflicts arising from both supermarkets vs. cooperatives and traditional vs. E-commerce channels are equilibrated. Further, multi-stage discounts are more effective than single-stage ones, but optimal discount ratios rely on the initial quantity of fresh agricultural produce in the supply chain; its market share in the traditional distribution channel; the potential market size; retail price; the price sensitivity coefficient of the channel; the cross-elasticity coefficient of prices between different channels; and the properties of the quantity loss.

The pop-in effect in nanoindentation of metals represents a major collective dislocation phenome-non that displays sensitivity in the local surface microstructure and residual stresses. To under-stand the deformation mechanisms behind pop-ins in metals, large scale molecular dynamics simulations are carried out to investigate the pop-in behavior and indentation size effect in unde-formed and deformed Cu single crystals. Tensile loading, unloading and reloading simulations are performed to create a series of samples subjected to a broad range of tensile strains with/without pre-existing dislocations. The subsequent nanoindentation simulations are con-ducted to study the coupled effects of pre-strain, the presence of resulting dislocations and surface morphology, as well as indenter size effects on the mechanical response in indentation processes. Our work provides detailed insights into the deformation mechanisms and microstruc-ture-property relationships of nanoindentation in the presence of residual stresses and strains.

Mushrooms have long rich history in folk medicine, traditional and functional foods due to high content of dietary myco-nutrients. Currently, there is increased interest in finding appropriate food-grade green ex-traction systems capable of extracting these bioactive compounds from dietary mushrooms for applica-tions in various food, pharmacological or nutraceutical formulations. Herein, we evaluated a modified Swiss water process (SWP) method using alkaline and acidic pH at low and high temperature under pressurized conditions as a suitable green food grade solvent to obtained extracts enriched with my-co-nutrients (dietary phenolics, total antioxidants (TAA), vitamins, and minerals) from Chaga. Ultra-high performance liquid chromatography coupled to high resolution accurate mass tandem mass spectrometry (UHPLC-HRAMS-MS/MS) was used to assess the phenolic compounds and vitamin levels in the extracts, while inductively coupled plasma mass spectrometry (ICP-MS) was used to determine the mineral con-tents. Over twenty phenolic compounds were quantitatively evaluated in the extracts and the highest total phenolic content and antioxidant activity was observed at pH11.5 at 100°C. The most abundant phenolic compounds present in Chaga extracts included phenolic acids such as protocatechuic acid 4-glucoside (0.7-1.08µg/mL), syringic acid (0.62-1.18µg/mL), and myricetin (0.68-1.3µg/mL). Vitamins are being reported for the first time in Chaga. pH 2.5 at 100°C treatment shows superior effects in extracting the B vitamins whereas pH 2.5 at 60 and 100°C treatments were outstanding for extraction of total fat-soluble vitamins. Vitamin E content was the highest for the fat-soluble vitamins in the Chaga extract under acidic pH (2.5) and high temp. (100°C) and ranges between 50 to 175 µg/100g Chaga. Antioxidant minerals ranged from 85.94 µg/g (pH7 at 100°C) to 113.86 µg/g DW (pH2.5 at 100°C). High temperature 100°C and a pH of 2.5 or 9.5. The treatment of pH11.5 at 100°C was the most useful for recovering phenolics and antioxidants from Chaga including several phenolic compounds reported for the first time in Chaga. SWP is being proposed herein for the first time as a novel, green food-grade solvent system for the extraction of myco-nutrients from Chaga and have potential applications as a suitable approach to extract nutrients from other matrices. Chaga extracts enriched with bioactive myconutrients and antioxidants may be suitable for further use or applications in the food and nutraceutical industries.

Our understanding of phylogenetic relationships among Gadiformes fish is obtained through the analysis of a small number of genes, but uncertainty remains around critical nodes. A series of phylogenetic controversial exists at the suborder, family, subfamily, and species levels. A total of 1105 orthologous exon sequences and translated amino acid sequences from 36 genomes and 12 transcriptomes covering 33 species were applied to investigate the phylogenetic relationships within Gadiformes and address these problems. Phylogenetic trees reconstructed with the amino acid data set using different tree-building methods (RAxML and MrBayes) showed consistent topology. The monophyly of Gadifromes was confirmed in our study. However, the three suborders Muraenolepidoidei, Macrouroidei, and Gadoidei were not well recovered by our phy-logenomic study, rejecting the validity of suborder Muraenolepidoidei. Four major lineages were revealed in this study. The family Bregmacerotidae forming clade I was the basal lineage of Gadiformes. The family Merluciidae formed clade II. Clade III contained families Melanonidae, Muraenolepididae, Macrouridae (with subfamilies Trachyrincinae, Macrourinae, and Bathygadinae), and Moridae. Clade IV contained at least three families of suborder Gadoidei, i.e., Gadidae, Phycidae, and Ranicipitidae. The subspecies of Lota lota from Amur River were confirmed, indicating that exon markers were a valid high-resolution method for delimiting subspecies or distinct lineages within species level. The PSMC analysis of different populations of L. lota suggests a continuous decline since 2 Myr.

This systematic review followed the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement to synthesizes the existing literature with a goal to review current conceptual frameworks of mental health of forced migrants for further practice research priorities in social work. The search was done between January 2015 to January 2021. As a result, 29 studies met inclusion criteria. Medicalizing mental health issues by relying solely on the effectiveness of medicine was a controversial risk factor that negatively affected the daily life activities of refugees and reduced their willingness for seeking professional mental health services. Empowering vulnerable minorities by giving them back their power and agency to be able to speak for themselves and raise voices of trauma and recovery was the missing protective factor for sustainable mental health practice. The benefits of group-based interventions are highlighted in which communities and individuals address mental health issues as well as isolation through building collective identities and support networks. Information and communication technologies (ICTs) can add more strength to any kind of mental health intervention. Finally, the benefits of applying ecological perspective for the mental health of refugees, and its implications for a sustainable intercultural practice are discussed. Social workers in this model are the representatives of at-risk groups, thus need more agency and creativity in reflecting client’s concrete needs.

Blood and/or urine levels of 27 heavy metals were determined by ICPMS in 41 patients with dilated cardiomyopathy (DCM) and 29 presumably healthy subjects from the Katanga Copperbelt (KC), in the Democratic Republic of Congo (DRC). After adjusting for age, gender, education level, and renal function, DCM probability was almost maximal for blood concentrations above 0.75 and 150 µg/dl for arsenic and copper, respectively. Urinary concentrations above 1 for chromium, 20 for copper, 600 for zinc, 30 for selenium, 2 for cadmium, 0.2 for antimony, 0.5 for thallium and 0.05 for uranium, all in μg/g of creatinine, were also associated with increased DCM probability. Concurrent and multiple exposures to heavy metals, well beyond permissible levels, are associated with increased probability for DCM. Study findings warrant screening for metal toxicity in case of DCM and prompt public health measures to reduce exposures in the KC, DRC.

The emergence of the Covid-19 pandemic has created both negative and positive changes, including implementing the circular economy across the globe. This Systematic Review follows the PRISMA statement and employs the Text Mining (Voyant Tools) technique to visualize and analyze the impacts of the Covid-19 on three aspects of the circular economy: economic, social, and environmental. The research employs Latent Dirichlet Allocation (LDA) to identify five major topics: (1) Shortage of medical equipment but high medical waste during Covid-19 due to the high demand in healthcare; (2) The long term negative impacts of lockdown on economic and social activities because of Covid-19 pandemic; (3) The reports on impacts of Covid-19 pandemic on the manufacturing globally, and their coping strategies and new opportunities; (4) The impacts of international restriction on the tourism, trade, shipping, and aviation industry, causing billion-dollar losses; (5) The reduction of pollution with health environment improvements with example cases from China and EU. The research identifies current literature gaps in the circular economy and Covid- 19 topics and encourages the application of text mining tools into researching to stimulate the research process and assist in communicating with the public.

The study assessed the changes in the quality and physical and chemical parameters of apples of four cultivars (‘Gala’, ‘Idared’, ‘Topaz’, ‘Red Prince’) subjected to mechanical vibrations during transport under model conditions and after storage (shelf-life). Quality changes in apples were evaluated based on skin and flesh colour, total soluble solids, dry matter, firmness, titratable acidity, pH value, total polyphenol content and antioxidant capacity. The applied vibrations at a frequency of 28 Hz caused changes in the above parameters, which were visible also after storage and depended on cultivar, but did not show any clear trend or direction. Skin colour varied whereas flesh colour remained stable. Vibrations resulted in a decrease in firmness. The greatest stability of quality parameters, the highest content of bioactive compounds and the highest antioxidant capacity were observed for ‘Red Prince’ and ‘Topaz’ apples – this refers to the control and treated samples before and after storage. However, total polyphenol content and antioxidant capacity increased in all studied cultivars as a result of vibrations and storage, which suggests that 28 Hz mechanical vibrations and short-term cold storage did not reduce the health promoting potential of the apples.

Soil organic carbon (SOC) sequestration in arable soils is a challenging goal for soil management. Multiple factors should be considered for the prediction of the soil capacity to fix atmospheric carbon. In this study, we focused on the effect of crop rotation and previous land use for future carbon sequestration on two experimental fields with identical soils (Retisols) and input of organic fertilizers. We analyzed the SOC dynamics and used the Roth C model to forecast SOC changes under RCP4.5 and RCP8.5 scenarios. Our experimental and modelling results indicated a consistent increase in SOC stocks and the stable fractions of soil organic matter (SOM). The increase in SOC was higher in the experiment with the crop-grassland rotation that in the experiment with a rotation of row crops and barley. With similar total SOC stocks, the efficiency of soil management differed as reflected by the contrasting composition of SOM, as fields with a long cultivation history showed higher SOM stability. The goal of 4‰ annual increase of SOC stocks may be reached under crop- grassland rotation in 2020-40 and 2080-90 when applying mineral or organic fertilizer system for scenario RCP4.5, and mineral fertilizer system in 2080-2090 for scenario RCP8.5.

The outbreak of SARS-COV-2 disease 2019 (COVID-19) abruptly changed the patterns in electricity consumption, challenging the system operations of forecasting and balancing supply and demand. This is due to the mitigation measures that include lockdown and Work from Home (WFH), which decreased the aggregated demand and remarkably altered its profile. Here, we characterise these changes with various quantitative markers and compare it with pre-COVID-19 business-as-usual data using Great Britain (GB) as a case study. The ripple effects on the generation portfolio, system frequency, forecasting accuracy and imbalance pricing are also analysed. An energy data extraction and pre-processing pipeline that can be used in a variety of similar studies is also presented. Analysis of the GB demand data during the March 2020 lockdown indicates that a shift to WFH will result to a net benefit for flexible stakeholders, such as consumer on variable tariffs. Furthermore, the analysis illustrates a need for faster and more frequent balancing actions, as a result of the increased share of renewable energy in the generation mix. This new equilibrium of energy demand and supply will require a redesign of the existing balancing mechanisms as well as the longer-term power system planning strategies.

The study investigates the determinants of mobile Internet banking adoption among Gen-Y in Malaysia. Align the issue of the study and research objectives, and the study underpinned Technology Acceptance Model (TAM) as the main guideline or a blueprint to analyze the research model. The study applied survey research design and analyzed using Structural Equation Modelling (SEM) under the PLS-SEM technique with SmartPLS 2.0. A total of 358 mobile internet banking users in Malaysia were random proportional selected as respondents and analyzed. Results from the partial least square structural equation modeling (PLS-SEM) revealed that perceived ease of use, perceived usefulness, facilitating condition, and personal innovativeness in IT have significantly influenced the attitude of mobile internet banking adoption in Malaysia. Additionally, perceived ease of use and facilitating conditions found to have a significant influence on the perceived usefulness of Mobile Internet Banking. Lastly, facilitating conditions and personal innovativeness in IT are significantly influence the perceived ease of use of mobile internet banking among Gen-Y in Malaysia

Cardiovascular disease (CVD) is considered to be one of the leading health issues in Thailand. CVD not only contributes to an increase in the number of hospital admissions year on year but also impacts on the rising health care expenditure for the treatment and long-term care of CVD patients. Therefore, this study is aimed at examining the impacts of risk reduction strategies on the number of CVD hospital admissions, Disability-Adjusted Life Years (DALYs) and the costs of hospitalisation. To estimate such impacts a CVD cost-offset model wasapplied using a Microsoft Excel spreadsheet. The number of the mid-year population was classified by age, gender and the CVD risk factor profiles from the recent Thai National Health Examination Survey (NHES) IV. This survey was chosen as the baseline population. The CVD risk factor profiles included age, gender, systolic blood pressure, total cholesterol, and smoking status. The Asia-Pacific Collaborative Cohort Study (APCCS) equation was applied to predict the probability of developing CVD over the next eight-year period. Estimates on the following were obtained from the model: (1.) the CVD events both fatal and non-fatal; (2.) the difference between the projected number of deaths and the actual number of deaths in that population; (3.) the number of patients who are expected to live with CVD; (4.) the DALYs from the estimated number of fatal and non-fatal events; (5.) the cost of hospital admissions. Four CVD risk strategy scenarios were investigated as follows: (1.) the do nothing scenario; (2.) the optimistic scenario; (3.) achieve the UN millennium development goal; and (4.) the worst-case scenario. The findings showed that over the next eight years there are likely to be 3,297,428 recorded cases of CVD; 5,870,049 cases of DALYs; and, approximately ฿57,000 million, ($1.9 billion), is projected as the total cost of hospital admissions. However, if the current health policy can reduce the levels of risk factors as defined in the optimistic scenario or such policy meets the specifications of the UN millennium development goal,there would be a significant reduction in the number of hospital admissions. These are estimated to be a reduction of 522,179 male and 515,416 female cases. With these results it is expected that health care costs would save approximately ฿9,000 million, ($298.3 million), for CVD and 900,000 million of DALYs over the next eight years. However, if there is an upward trend in the risk factors as predicted in the worst-case scenario, then there will be an increase of 428,220 CVD cases; consequently, DALYs cases may rise by 766,029 while the hospitalisation costs may increase by approximately ฿7,000 million, ($232.1 million). Based on our findings, reducing the levels of CVD risk factors in the population will drastically reduce: (1.) the number of CVD cases; (2.) DALYs cases; and (3.) health care costs. Therefore it is recommended that the health policy should enhance the primary prevention programs which would be targeted at reducing the CVD risk factors in the population.

Salmon farming has been blamed for the collapse of the sea trout (Salmo trutta) fishery in Loch Maree on Scotland’s west coast despite the absence of any direct evidence. Stocks of west coast demersal marine fish, especially around the Clyde Estuary have also declined over a similar time span. The decline of these marine fish stocks can be attributed to the removal of the “three-mile fishing limit” in 1984 by UK Government legislation. Sea trout inhabit the same inshore waters as targeted demersal fish and can be caught as by-catch. Comparisons of the decline of demersal species and the sea trout from Loch Maree and the west coast show a high degree of correlation. Stocks of whiting (Merlangius merlangus) from inshore waters have found to consist of small fish which mirrors the stock makeup of the Loch Maree sea trout stock.

This paper identifies the characteristics of the farmer that affect the degree of farmer’s perceived-impact of climate change (CC). We use data from the Indonesian Rice Farm Household survey consisting of 87,330 farmers. An ordered probit regression model was used to estimate the effect of each variable on the degree of perceived-impact of CC. The results of this study confirm the previous empirical studies. Several variables that have been identified as having a positive effect on farmer adaptation practices such as farmer education, land tenure, irrigation infrastructure, cropping system, chemical fertilizer application, access to extension services and participation in farmer group affect the degree of CC perceived-impact negatively. However, a different result was found in the estimation of the gender variable. We found that female farmer has a higher resilience toward CC than the male farmer does. Furthermore, the female farmer has a more positive perception about future farming conditions than the male does. Finally, we suggest that the implementation of national adaptation policy should prioritize more to the farmer with insecure land tenure and utilize and expand the channel of agricultural extension services to deliver the planned adaptation policy.

Many strategies have been developed for the synthesis of silicon carbide (SiC) thin films on silicon (Si) substrates by plasma-based deposition techniques, especially plasma enhanced chemical vapor deposition (PECVD) and magnetron sputtering, due to importance of these materials for microelectronics and related fields. A drawback is the large lattice mismatch between SiC and Si. The insertion of a thin aluminum nitride (AlN) buffer layer between them has been shown useful to overcome this problem. Herein, the high-power impulse magnetron sputtering (HiPIMS) technique was used to grow SiC thin films on AlN/Si substrates. Furthermore, the SiC films were also grown on Si substrates. Comparisons of the structural and chemical properties of SiC thin films grown on the two types of substrates allowed us to evaluate the influence of AlN buffer layer on such properties. The chemical composition and stoichiometry of the samples were investigated by Rutherford backscattering spectrometry (RBS) and Raman spectroscopy, while the crystallinity was characterized by grazing incidence X-ray diffraction (GIXRD). Our set of results evidenced the versatility of HiPIMS technique to produce polycrystalline SiC thin films at near room temperature only varying the discharge power. In addition, this study opens up a feasible route for the deposition of crystalline SiC films with a good structural quality using AlN buffer layer.

Capsicum annuum var. glabriusculum, is a variety of wild chili pepper belonging to the family Solanaceae and is considered as the origin for all cultivated chili species of the world. This species is an important genetic resource for agriculture and food, is widely distributed in northeastern Mexico in altitudes from 0 – 1200 m.a.s.l. This species grows mainly at low altitudes and its upper limit reaches 1000m., it prefers temperatures above 18.3^O C and its production and harvest may ocurr at two seasons, one during the beginning of the summer and the main one ocurring in the middle of the autumn in northeast México. It is estimated that the main production occurs in the state of Tamaulipas with 84 tons per year and is harvested from 23 municipalities. Concentration of capseicins and dihydrocapsaicine from wild populations may vary considerably from one location to another in the municipalities, ecotypes and diverse climatic conditions from this wide geographic zone. The high demands of wild chili as well as the variability on concentration of capseicins in fruits are considered as some of the main reasons why intensive cultivation of this species should be carried out in Northeastern Mexico.

Introduction Recent evidence from relatively small randomized controlled trials would seem to support a useful role of ranolazine for the prevention and treatment of atrial fibrillation (AF). The present study is aimed at providing information about the possible beneficial anti-arrhythmic properties of ranolazine. In particular, the meta-analysis carried out in this study focuses on the application of ranolazine to prophylaxis and treatment of atrial fibrillation.Methods Both randomized controlled trials (RCTs) and non randomized observational studies concerning the effects of ranolazine on AF were included in the meta-analysis. In each of the considered studies, a comparison was made between a group of patients taking ranolazine and a second group treated instead with another antiarrhythmic therapy , or assigned to placebo. Efficacy outcomes were the risk of new- onset AF, the probability of conversion to sinus rhythm of patients with recent occurrence(≤ 48 h)of AF and the time to conversion to sinus rhythm. Safety endpoints were death, adverse events, QTc prolongation and hypotension.Results Ten studies ( 8 RCTs and 2 nonrandomized observational studies) were gathered on the whole. Ranolazine was effective in preventing the occurrence of AF when compared to controls (RR= 0.60; 95% CI: 0.43–0.83; p = 0.002). Subgroup analysis showed a more pronounced preventive effect of ranolazine against AF in the postoperative setting of coronary artery bypass grafting(CABG) surgery (RR= 0.39; 95% CI: 0.18-0.83; p=0.02) when compared to non- postoperative AF (RR= 0.76; 95% CI: 0.63-0.92; p=0.04). Ranolazine enhanced the chances of successful cardioversion when added to intravenous amiodarone compared to amiodarone alone (RR 1.18; 95% CI: 1.05–1.33; p = 0.004) and significantly decreased the time to cardioversion(SMD= −10.35 h; 95% CI: −18.13 hours to − 2.57 hours; p < 0.001). Overall risks of death, adverse events, and QTc prolongation were shown to be similar in the comparison between patients treated with ranolazine and controls. Conclusions Ranolazine given orally at appropriate doses showed the property to significantly quicken the conversion of AF to sinus rhythm when combined with the iv amiodarone, compared to iv amiodarone alone . Furthermore, in patients in sinus rhythm, ranolazine proved to reduce the frequency of new onset AF as well as of its recurrences, especially in patients undergone CABG surgery, known to be at high risk of developing postoperative AF. In addition, ranolazine use seems to be safe and associated with relatively few adverse events.

From June 18 to 19, 2013, the Ésera river in the Pyrenees, Northern Spain, caused widespread damage due to flooding as a result of torrential rains and sustained snowmelt. We estimate the contribution of snow melt to total discharge applying a snow energy balance to the catchment. Precipitation is derived from sparse local measurements and the WRF-ARW model over three nested domains, down to a grid cell size of 2 km. Temperature profiles, precipitation and precipitation gradient are well simulated, although with a possible displacement regarding the observations. Snowpack melting was correctly reproduced and verified in three instrumented sites, and according to satellite images. We found that the hydrological simulations agree well with measured discharge. Snowmelt represented 33% of total runoff during the main flood event and 23% at peak flow. The snow energy balance model indicates that most of the energy for snow melt during the day of maximum precipitation came from turbulent fluxes. This approach forecast correctly peak flow and discharge during normal conditions at least 24h in advance and could give an early warning of the extreme event 2.5 days before.

Structural variations (SVs) play a key role in the pathogenicity of hematological malignancies. Optical genome mapping (OGM) is an emerging technology that enables genome-wide detection of all classes of SVs at a high resolution and sensitivity. Identification of cryptic SVs leading to gene disruption or predicted novel gene fusions could be important drivers for cancer development and/or portend a prognostic relevance, which could be used to modify the treatment plan. A cohort of 106 consented cases that had a successful OGM analysis performed were included in the study. Demographic, clinical, laboratory and treatment data were collected. Routine diagnostic and prognostic testing were done on the peripheral blood and bone marrow aspirate as indicated. Additional samples of peripheral blood and/or bone marrow were sent for OGM testing. OGM led to a change in risk stratification in 17/66 (25.75%) of patients with hematological malignancies, the majority of these patients (15/66, 22.72%), having their risk stratification upgraded with a resulting change in treatment of 14 patients. This study highlights the ability of OGM to detect rare, cryptic and clinically relevant variants that potentially impact disease diagnosis, risk stratification and actionable treatment targets.

X-band marine radar captures signal reflected from the sea surface. Theoretical studies indicate that the initial unfiltered signal contains meaningful information including parameters related to wind waves. Traditional methods for estimating significant wave height (SWH) rely on the physical laws describing signal reflection from rough surfaces. However, recent studies suggest the feasibility of employing artificial neural networks (ANNs) for SWH approximation. Both classical and ANN-based approaches necessitate costly in situ data. In this study, we propose generating synthetic radar images with specified wind wave parameters using Fourier-based approach and Pierson–Moskowitz wave spectrum as a viable alternative. We generate synthetic images and use them for unsupervised learning approach to train a convolutional component of an ANN. After that, we train a regression ANN based on the previous convolutional component to obtain SWH back from synthetic images. Then, we apply preliminary trained weights for the same regression model to train SWH approximation on the dataset of real sea clutter images. In this study, we demonstrate the increase in the accuracy of SWH estimation from radar images with the preliminary training on synthetic data.

The impact of the cell community on its individual components in the prokaryotic realm is often overlooked. However, in the case of intracellular pathogens, where each infected cell can be considered as a single community, understanding how a population adapts to its environment to evolve and successfully propagate is key. Chlamydia infections are characterised by a silent propagation of the bacteria within individual hosts and the wider population. Chlamydia are strict intracellular pathogens residing within a specialised membrane-bound compartment called the inclusion. The life cycle of Chlamydia involves altering between the invasive elementary bodies (EBs) and replicative reticulate bodies (RBs). We have used cryo-soft X-ray tomography to observe individual inclusions, combining excellent resolution (40 nm) and large volume imaging (up to 16 µm). Combined with a semi-automated segmentation pipeline, we were able to consider each inclusion as an individual bacterial niche. Within the inclusion, we identified and classified different forms of the bacteria and confirmed the recent finding that RBs have a variety of volumes (small, large and abnormal). Moreover, we demonstrate that the proportions of these different RB forms depend on the bacterial concentration in the cell demonstrating the impact of the group on its individual component. We conclude that each inclusion operates as an autonomous community which regulates the characteristics of individual bacteria within the inclusion

This work aimed to develop an anionic cellulose nanofiber (CNF) bio-adsorbent from palm date tree waste and to investigate its removal efficiency against cationic methylene blue dye from contaminated water. Palm date pulp was first prepared from palm date leaves through acid hydrolysis using H2SO4, followed by hydrolysis in a basic medium using KOH, in which the process completely removed the components of hemicellulose, lignin, and silica. To obtain anionic CNF, the resulting pulp was further treated with H2SO4, followed by centrifugation. Biogel formation of the CNF suspension was promoted by sonication, where its removal efficiency of methylene blue dye was studied as a function of dye concentration, temperature, contact time, and pH value. Two equilibrium models, the Langmuir and Freundlich models were employed, and the Langmuir model was found to be consistent with the experimental data. The highest removal efficiency was obtained at 60oC and was 5mg/gm. Furthermore, several kinetic models were used to gain insight into the adsorption mechanism. The pseudo-second-order model provided an accurate description of the adsorption process, while the Elovich equation suggested a chemical reaction between methylene blue dye and CNF. The study’s findings were in agreement with the pseudo-second-order model, indicating general chemical reactions. The study indicates that CNF adsorbents derived from renewable natural waste sources such as palm date leaves can be effective in removing cationic contaminants such as methylene blue dye.

The formation and localization of sporadic E(Es) layers predicted by the ions vertical drift velocity and its vertical change in the lower thermosphere during nighttime are shown analytically and by numerical simulations. The consideration of existence of a minimum negative value of the vertical change of the ions vertical drift velocity as a necessary condition of formation of Es layer and determining ions convergence rate into this layer, is extended in case of the presence of vertical wind. Upward vertical wind can shift the convergence regions upward, while downward vertical wind shift them downward, unlike the cases of presence of only meridional and zonal winds. It also changes the ion convergence rate compared to the one with just a horizontal wind. It is shown for the first time that the upward constant wind also causes the convergence of ions with maximum rate in the region where the ion-neutral collision frequency is equal to their cyclotron frequency. While demonstrating the presented theory by numerical simulations, HWM14 data is used for the meridional and zonal wind velocity profiles and the presence of its vertical component is assumed. In this case, in addition to the estimated ion drift velocity and its vertical changes, their initial distribution and ambipolar diffusion also determine the development of ion convergence/divergence processes. For small magnitude of vertical wind velocity, its significant influence on the ions/electrons behavior is demonstrated, which shows the importance of both tidal wind and wind changes caused by the propagation of atmospheric gravity waves on the formation of the Es layer. In this theoretical research it is shown that the realistic profile of the wind velocity, which takes into account the vertical component along with its zonal and meridional ones, is important for prediction of the Es layers formation, as well as regions of ion depletion.

It is known that exposure to heavy metals such as lead (Pb) and cadmium (Cd) has several adverse effects, particularly on the human reproductive system. Pb and Cd have been associated with infertility in both men and women. In pregnant women, they have been associated with spontaneous abortion, preterm birth, and impairment of the development of the fetus. Since these heavy metals come from both natural and anthropogenic activities and their harmful effects have been observed even at levels of exposure, their exposure remains a public health issue, especially for the reproductive system. Given this, the present study aimed to investigate the potential reproductive effects of Pb and Cd levels in the follicular fluid (FF) of infertile women and no-smokers exposed to heavy metals for professional reasons or living in rural areas near landfills and waste disposal areas, to correlate the intrafollicular presence of these metals with possible alterations in the ultrastructure of human cumulus-oocyte complexes (COCs), probably responsible of infertility. Blood and FF metals were measured using atomic absorption spectrometry. COCs corresponding to each FF analyzed were subjected to ultrastructural analyses by transmission electron microscopy. We demonstrated for the first time that intrafollicular levels of Pb (0.66 µg/dL to 0.85 µg/dL) and Cd (0.26 µg/L - 0.41 µg/L) could be associated with morphological alterations of both the oocyte and CCs ultrastructure. Since blood Cd levels (0.54 µg/L - 1.87 µg/L) were above the current reference values established by the guidelines of the Agency for Toxic Substances and Disease Registry (ATSDR) and the Environmental Protection Agency (EPA), whereas blood Pb levels (1.28 µg/dL - 3.98 µg/dL) were below the ATSDR reference values we believe that these alterations could be due especially to Cd, even if we cannot exclude a possible additional effect of Pb. Our results highlighted that oocytes were affected in maturation and quality, whereas CCs showed scarcely active steroidogenic elements. Regressing CCs, with cytoplasmic alterations, were also numerous. According to Cd's endocrine-disrupting activity, the poor steroidogenic activity of CCs might correlate with delayed oocyte cytoplasmic maturation. So, we conclude that levels of heavy metals in the blood and the FF might negatively affect fertilization, embryo development, and pregnancy, compromising oocyte competence to fertilization both directly and indirectly, impairing CC steroidogenic activity, and inducing CC apoptosis.

Historically, fortified wines originated in Europe, and they have in common a high alcohol content to increase their shelf-life during long journeys to northern Europe and the American continent. Nowadays, the world’s better-known Marsala, Port, Sherry, and Vermouth due to their high alcoholic content, sweet taste, and intense aromatic profile, are designated as dessert wines and sometimes served as aperitifs. This review gives an overview of the traditional vinification process, including the microbiota and autochthonous yeast, the use of aromatic botanicals, and regulatory aspects of the main Italian, Portuguese, and Spanish fortified wines. The wine-making process is essential to defining the volatile organic compounds (VOCs) that characterize the aroma of each fortified wine, giving them an organoleptic fingerprint and “terroir” characteristics. The various volatile and odorous compounds found in fortified wines during oxidative and thermal aging are discussed in the last part of this review.

Using the onset of the COVID 19 pandemic, this chapter examines the cryptocurrencies as safe haven investment for stocks of our time varying realization as to the economic chock centralized by the growing pandemic. Using daily data of COVID 19 measures and daily prices for 4 cryptocurrencies and 4 stocks assets for the whole year 2020, we apply both the VAR-DCC-GARCH and Wavelet Coherency models. New evidence of our chapter find that the Bitcoin and Etherum are highly correlated in the short and long horizon with the selected stocks. However for the case of the Litecoin and the XRP are correlated negatively with the stocks in the whole COVID19 period. We find evidence that, Bitcoin is strong safe haven asset for all the selected stocks during the COVID19 era, while the Litecoin is weak safe haven investment for all the stocks and the XRP is with lowest potential of safe haven investment for all the studied stocks. Within the study we are providing a diversification of hedging for the investors and policy makers suggesting that the cryptocurrencies acted as safe haven investment similar to the precious metals during historic crisis and as fiat money for any economic shocks might occurred. The abstract should summarize the contents of the paper in short terms, i.e. 150-250 words.

Both drones and laser scanners digitally take the as-built context of an object into the computer and the data taken is transmitted to a Building Information Modeling (BIM) world to create ac-curate 3D models. Although the laser scanner is the leading method of the Scan-to-BIM proce-dure, many professionals indicate drawbacks of the technology and point out the drone is an al-ternative that can improve the shortcomings, leading to the UAV-to-BIM process. Korean con-struction industry plans to implement the drone technology for scrutinizing as-built construc-tion quality by 2025. However, the drone is not popular in the construction projects. Korean universities where Construction Engineering and Management program have been implement-ed are requested to develop a drone curriculum for construction professionals. Since the majori-ty of the professionals are not familiar with drone operation, in order for the schools to be suc-cessful in developing the curriculum, it is very necessary to perform a preliminary experimental study for identifying the essential education contents that are appropriate to drone beginners. The main objective of this paper is to perform the study for the drone beginners and recognize the recommendations and the framework of drone curriculum that will be beneficial for the schools to develop a comprehensive curriculum later on.

The synthesis of nitrogen-based heterocycles has always been considered essential in the development of pharmaceuticals in medicine and agriculture. This explains why various synthetic approaches have been proposed in recent decades. However, performing as methods often imply harsh conditions or the employment of toxic solvents and dangerous reagents. Mechanochemistry is undoubtedly one of the most promising technologies currently used for reducing any possible environmental impact due to the worldwide interest in developing solvent-free synthetic pathways. Following this line, we propose a renewed mechanochemical protocol for synthesizing various heterocyclic classes by exploiting the reducing proprieties and the electrophilic nature of thiourea dioxide (TDO). Simultaneously using the ready availability and low cost of a component of the textile industry such as TDO and all the advantages brought by a green technique such as mechanochemistry, we plotted the route towards a more sustainable and eco-friendly methodology for obtaining heterocyclic moieties.

The article presents a literature review of three Chinese manuscripts containing natural dyes recipes and three containing synthetic dyes from the Ming Dynasty to the Republican Period. The manuscripts mentioned were exclusively used as references and sources. Four databases were used to access the original documents, then, a translation from old mandarin to Spanish was made. For natural dyes, the results show four dyestuffs were commonly used to produce colors, sappanwood (Caesalpinia sappan L.), followed by safflower (Carthamus tinctorius L.), indigo (Indigofera tinctoria L.), and sophora (S. japonicum L.). While the synthetic dyes exported to or produced in China were mainly bluish, greenish, and violet probably because they were difficult to obtain from natural ones. The literature review of the dyes and their recipes can be a key factor in any art history or conservation study, improving the understanding of how the colors were achieved and as complementary information for analytical analyses. It provides useful details that contribute to the preservation of Chinese dye history on silk heritage.

Overimitation, the copying of causally irrelevant or non-functional actions, is well-known from humans but completely absent in other primates. Recent studies from our lab have provided evidence for overimitation in canines. Previously, we found that half of tested pet dogs copied their human caregiver's irrelevant action, while only few did so when the action was demonstrated by an unfamiliar experimenter. Therefore, we hypothesized that dogs show overimitation as a result of socio-motivational grounds. To test this more specifically, here we investigated how the relationship with the caregiver influenced the eagerness to overimitate. Given the high variability in the tendency to overimitate their caregiver, we hypothesized that not only familiarity, but also relationship quality influences whether dogs faithfully copy their caregiver. For this purpose, we measured on the one hand the overimitation tendency (with the same test as in the two studies before) and on the other hand the relationship quality between the dogs and their caregivers. Although not significant, results revealed that dogs who overimitated seemed to show more referential and affiliative behaviours towards the owner (like gazing, synchronization and greeting) than dogs who showed less or no copying of the irrelevant action. Possible reasons for these findings are discussed.

The international debate on the adaptive re-use of cultural heritage sites following the Sustainable Development Goals becomes more central than ever in the implementation of circular economy models for urban policies. The new values that characterise the cultural assets, considered as the result of a collaborative process, can enhance both the manufactured capital and the human capital, and to carry out the system of relationships that bind them. At the same time, the values of historical-artistic assets and produced by community-based regeneration processes are particularly relevant when they characterise abandoned commons and cult buildings, to which communities attribute an identity and symbolic value. Starting from the definition of the concept of Complex Social Value, we propose a methodological process that combines approaches and techniques typical of deliberative evaluations and collaborative decision-making processes. The aim is to identify the complex value chains generated by adaptive re-use, in which intrinsic values can play a driving role in the regeneration strategies of discarded cultural heritage. The experimentation, tested with the project “San Sebastiano del Monte dei Morti Living Lab” (SSMOLL), activates a creative and cultural Living Lab in the former church of “Morticelli”, in the historic centre of Salerno, in southern Italy. The re-use project is part of a more comprehensive process of social innovation and culture-led urban regeneration triggered in Salerno starting from SSMOLL.

In the present work, we provide an electronic structure based method for the “on-the-fly” deter- mination of vibrational sum frequency generation (v-SFG) spectra. The predictive power of this scheme is demonstrated at the air-water interface. While the instantaneous fluctuations in dipole moment are obtained using the maximally localized Wannier functions, the fluctuations in polar- izability are approximated to be proportional to the second moment of Wannier functions. The spectrum henceforth obtained captures the signatures of hydrogen bond stretching, bending, as well as low-frequency librational modes.

This paper examines whether the Great Recession has altered the disparities of the US regional health care expenditures. We test the null hypothesis of convergence for the US real per capita health expenditure for the period 1980-2014. Our results indicate that the null hypothesis of convergence is clearly rejected for the total sample as well as for the pre-Great Recession period. Thus, no changes are found in this regard. However, we find that the Great Recession has modified the composition of the estimated convergence clubs, offering a much more concentrated picture in 2014 than in 2008, with most of the states included in a big club, and only 5 (Nevada, Utah, Arizona, Colorado and Georgia) exhibiting a different pattern of behavior. These two estimated clubs diverge and, consequently, the disparities in the regional health sector have increased.

Many empirical and theoretical studies indicate that Brownian motion and diffusion models as its mean field counterpart provide appropriate modelling techniques for individual insect movement. However, this traditional approach has been challenged and conflicting evidence suggests that an alternative movement pattern such as Lévy walks can provide a better description. Lévy walks differ from Brownian motion since they allow for a higher frequency of large steps, resulting in a faster movement. Identification of the ‘correct’ movement model that would consistently provide the best fit for movement data is challenging and has become a highly controversial issue. In this paper, we show that this controversy may be superficial rather than real if the issue is considered in the context of trapping or, more generally, survival probabilities. In particular, we show that almost identical trap counts are reproduced for inherently different movement models (such as the Brownian motion and the Lévy walk) under certain conditions of equivalence. This apparently suggests that the whole ‘Levy or diffusion’ debate is rather senseless unless it is placed into a specific ecological context, e.g. pest monitoring programmes.

We introduce a novel algebraic structure, termed algebra B, which generalizes Lie algebras through the definition of a non-associative and unital algebra. We demonstrate that algebra B retains essential properties such as bilinearity and antisymmetry, and satisfies both the Jacobi and Malcev identities; this occurs when the product operations of Lie and Malcev algebras are derived from the product operation defined in our algebra. By examining the connections between algebra B, Malcev algebras, and Lie algebras, we establish that algebra B effectively generalizes these structures. Furthermore, we show that algebra B can generate complex entities with a novel structure distinct from those currently known. Our findings lay the groundwork for future investigations into the practical applications and further theoretical development of this new algebraic framework.

For colloids of NaYF4:Yb3+/Tm3+ nanoparticles in DMSO by the method of time-resolved lumi-nescence spectroscopy with nanosecond pulsed excitation at a wavelength of 975 nm the photo-physical processes that determine the course of kinetic curves have been revealed. It has been found that the luminescence rise time decreases with an increase of the concentration of activators and sensitizers due to increase of the efficiency of energy transfer from sensitizers to activators. Cross-relaxation of the excited states of activators provides a decrease of the lumi-nescence decay time with an increase of the concentration of activators and a constant concentration of the sensitizer. There was no correlation between the time of luminescence decay with the change of the concentration of sensitizers and constant concentration of activators due to the competition of the processes of energy back transfer from activators to sensitizers and the "feeding" of activators by excitations coming from remote sensitizer ions.

Fire is a common natural disturbance in forest ecosystems and plays an important role in subsequent vegetation patterns. Based on the spatial sequence method instead of the time successional sequence method, this study selected burned areas in different locations in the Anning River Basin, which contains typical dry valleys. Quadrat surveys and quantitative classification were used to identify the vegetation classification, distribution pattern, and environmental interpretation during the natural restoration process after forest fire. The results showed that: (1) the vegetation community in the early stage of natural recovery after forest fire disturbance could be divided into seven community types, and Quercus guyavaefolia H. Leveille (Qg) was the dominant species in the community; (2) vegetation samples could be divided into five ecological types, and the classification and distribution pattern of community types in this region changed most obviously with altitude; and (3) detrended correspondence analysis could clearly classify vegetation community types, and detrended canonical correspondence analysis could well reveal the relationships between species and environmental factors. This study provides a scientific basis guiding the restoration of ecosystem structural stability and biodiversity in burned areas.

The gut microbiota plays an important role in the physiological activities of the host and affects the formation of important economic traits in agricultural animals. We investigated the effects of cecal microbiota on chicken weights using the Guizhou yellow chicken as a model. We collected experimental cohorts from chickens with high (HC, n=16) and low body weights (LC, n=16) and integrated microbial 16S rRNA gene sequencing and non-targeted serum metabolome data to explore the effect and its metabolic mechanism of cecal microbiota on market weight. The genera Lachnoclostridium, Alistipes, Negativibacillus, Sellimonas and Ruminococcus torques group were enriched in the HC group while Phascolarctobacterium was enriched in the LC group (P<0.05). Metabolomic analysis determined that pantothenic acid, luvangetin (2H-1-benzopyran-6-acrylic acid) and menadione (vitamin K) were significantly higher in HC serum while beclomethasone dipropionate (a glucocorticoid) and chlorophene (2-benzyl-4-chlorophenol) were present at higher levels in the LC group. The microbes enriched in HC that were significantly positively correlated with metabolites including pantothenic acid and menadione and negatively correlated with beclomethasone dipropionate and chlorophene. These results indicated that specific cecal bacteria in Guizhou yellow chickens alter the host metabolism and growth performance. This study provides a reference for revealing the mechanism of cecal microbe actions that affect chicken body weight.

Over the last several decades, China has continuously introduced Duroc boars and used them as breeding boars. Although this crossbreeding method has increased pork production, it has affected pork quality. Nowadays, one of the primary goals of industrial breeding and production systems is to enhance the quality of meat. This research adds to our understanding of the molecular mechanisms that control the quality of pork and may be used as a guide for future efforts to enhance meat quality. We investigated the genetic mechanisms of cross-breeding for meat quality improvement by combining transcriptome and metabolome analysis, using Chinese native Jiaxing black (JXB) pigs and crossbred Duroc × Duroc × Berkshire × JXB (DDBJ) pigs. In the longissimus Dorsi muscle, the content of inosinic acid, polyunsaturated fatty acid, and amino acids was considerably higher in JXB pigs in contrast with that of DDBJ pigs, whereas DDBJ pigs have remarkably greater levels of polyunsaturated fatty acids than JXB pigs. Differentially expressed genes (DEGs) and differential metabolites were identified using transcriptomic and metabolomic KEGG enrichment analyses. Differential metabolites mainly include amino acids, fatty acids, phospholipids. In addition, we found several DEGs that may explain differences in meat quality between the two pig types, including genes associated with lipid metabolism (e.g., DGKA, LIPG, and LPINI), fatty acid metabolism (e.g., ELOVL5, ELOVL4, and ACAT2), and amino acid metabolism (e.g., SLC7A2, SLC7A4). Combined with the DEGS-enriched signaling pathways, the regulatory mechanisms related to amino acids, fatty acids, and phospholipids were mapped. The abundant metabolic pathways and DEGs may provide insight into the specific molecular mechanism that regulates meat quality. Optimizing the composition of fatty acids, phospholipids, amino acids, and other compounds in pork is conducive to improving meat quality. Overall, these findings will give useful information and further groundwork for enhancing the meat quality that may be achieved via hybrid breeding.

Kenya’s construction industry is experiencing exponential growth in tandem with construction trends globally. With the growth experienced in the industry, there has been significant growth in the economy and a 50% contribution to the world’s landfill waste and pollution to the adjacent environment. Globally, the construction industry is among the largest consumers of natural resources and significant contributors to pollution. This has given rise to high pressure to adopt environmentally sensitive approaches in the construction industry to present a competitive advantage. It is, therefore, crucial to address the need for sustainability measures for Landscape Architecture projects to increase knowledge and awareness, create incentives geared towards supporting sustainable practices, and leverage legal instruments and policies. Green construction practices and strategies have positively impacted the environment and the Kenyan construction industry’s social and economic performance. However, there are several barriers to the adoption and improvement of monitoring and evaluation of sustainable practices, thus slowing down the industry in taking charge of sustainability.

Large values and gradients of stresses and deformations, triggering concentrations of stresses and deformations, arise in the corner areas of a structure. The action of forced deformations, leading to the finite rupture of the contact between the elements of a structure, also triggers the concentration of stresses, while the rupture reaches an irregular point, a line on the area boundary. The theoretical analysis of the stress-strain state (SSS) of areas with angular cutouts in the boundary under the action of discontinuous forced deformations is reduced to the study of singular solutions to the homogeneous problem of the elasticity theory that has power-related features. The calculation of stress concentration coefficients in the domain of a singular solution to the elastic problem makes no sense. It is experimentally proven that the zone, that is close to the vertex of the angular cutout in the area boundary, has substantial deformations, rotations, and it corresponds to rising values of the first and second derivatives of displacements along the radius in cases of sufficiently small radii in the neighbourhood of the irregular point of the boundary. For such areas, it is necessary to consider the plane problem of the elasticity theory, taking into account the geometric nonlinearity under the action of forced deformations. This will allow analyzing the effect of relations between orders of values of deformations, rotations, and forced deformations on the form of the equation of equilibrium. The purpose of this work is to analyze the effect of relations of deformation orders, rotations, forced deformations on the form of the equilibrium equation in the polar coordinate system for a V-shaped area under the action of forced temperature-induced deformations with regard for the geometrical non-linearity and physical linearity.

The main objective of this study is to find out the influence of cooperation and intra-specific competition in escaping predation through refuge of the prey population and the effect of the two intra-specific interactions on the dynamics of prey-predator systems. For this purposes, two mathematical models with Holling type-II functional response function have been proposed and analyzed. The first model includes cooperation among prey populations whereas the second one incorporates intra-specific competition. Existence conditions and stability of different equilibrium points of both models have been carried out for the qualitative behaviour of the systems. Refuge through intra-specific competition has a stabilizing role, whereas cooperation has a destabilizing role on the system dynamics. Periodic oscillations are observed in both the systems through Hopf bifurcation. From the analytical and numerical findings, we conclude that intra-specific competition affects the prey population and continuously checks the refuge class under a critical value, and thus it never becomes too large to cause predator extinction due to food scarcity. Conversely, cooperation leads maximum individuals to escape predation through the refuge so that predators will suffer from low predation success.

It is known that high N doses, N/K imbalances, and frequent irrigation favor verticillium wilt. The influence of fertilization and its interaction with the frequency of irrigation on the development of Verticillium wilt of olive (VWO) has been evaluated. A split-split-plot design in microplots with two naturally infested soils of different texture was established for studying three fertilization treatments (NO3Ca, N-P-K and without fertilization), plus two irrigation frequencies (daily and deficit). The treatments were applied by means of fertigation, evaluating the susceptible cultivar Picual. Final disease incidence in plants subjected to NO3Ca-daily treatment was 100% regardless soil texture. However, final mortality in these plants was 37% and 85.2% in clay and sandy loam soils, respectively. As well, the area under the disease progress curve values were significantly higher (49.1%) in plants subjected to NO3Ca fertilization compared to those not fertilized or fertilized with N-P-K when plants grown in clay soil. This value in the sandy loam soil was significantly higher in the NO3Ca-daily irrigation treatment (94.3%), followed by the N-P-K-daily treatment (61.1%) which also was significantly higher than the unfertilized-daily, N-deficit and NPK-deficit treatments (37.8, 42.6 and 44.9 %, respectively). The plants submitted to unfertilized-deficit treatment reached the lowest value 9.6%. In this work it can be concluded that the application of fertilizer or the application of fertilizer with daily frequency irrigations in naturally infested soils increases the development of VWO in 'Picual'.

With the rapid development of communication technology, connected vehicles (CV) have the potential, through the sharing of data, to enhance vehicle safety and reduce vehicle energy consumption and emissions. Numerous research efforts have been conducted to quantify the impacts of CV applications, assuming instant and accurate communication among vehicles, devices, pedestrians, infrastructure, the network, the cloud, and the grid, collectively known as V2X (vehicle-to-everything). The use of cellular vehicle-to-everything (C-V2X), to share data is emerging as an efficient means to achieve this objective. C-V2X releases 14 and 15 utilize the 4G LTE technology and release 16 utilizes the new 5G new radio (NR) technology. C-V2X can function without network infrastructure coverage and has a better communication range, improved latency, and greater data rates compared to older technologies. Such highly efficient interchange of information among all participating parts in a CV environment will not only provide timely data to enhance the capacity of the transportation system but can also be used to develop applications that enhance vehicle safety and minimize negative environmental impacts. However, before the full benefits of CV can be achieved, there is a need to thoroughly investigate the effectiveness, strengths, and weaknesses of different CV applications, the communication protocols, the varied results with different CV market penetration rates (MPRs), the interaction of CVs and human driven vehicles, the integration of multiple applications, and the errors and latencies associated with data communication. This paper reviews existing literature on the environmental, mobility and safety impacts of CV applications, identifies the gaps in our current research of CVs and recommends future research directions. The results of this paper will help shape the future research direction for CV applications to realize their full potential benefits.

Boron Neutron Capture Therapy (BNCT) is a promising binary disease-targeted therapy, as neutrons preferentially kill cells labeled with boron (¹⁰B), which makes it a precision medicine treatment modality that provides a therapeutic effect exclusively on patient-specific tumor spread. Contrary to what is usual in radiotherapy, BNCT proposes cell-tailored treatment planning rather than to the tumor mass. The success of BNCT depends mainly on the sufficient spatial biodistribution of ¹⁰B located around or within neoplastic cells to produce a high-dose gradient between the tumor and healthy tissue. However, it is not yet possible to precisely determine the concentration of ¹⁰B in a specific tissue in real-time using noninvasive methods. Critical issues remain to be resolved if BNCT is to become a valuable, minimally invasive, and efficient treatment. Moreover, functional imaging technologies such as PET can be applied to determine biological information that can be used for the combined-modality radiotherapy protocol for each specific patient. Anyway, not only imaging methods but also proteomics and gene expression methods will facilitate BNCT becoming a modality of personalized medicine. This work provides an overview of the fundamental principles, recent advances, and future directions of BNCT as cell-targeted cancer therapy for personalized radiation treatment.

In 2008, Ecuador recognized the Constitutional Rights of Nature in a global first. This recognition implies a major shift in the human-nature relationship, from one between a subject with agency (humans) and an exploitable object (Nature), to a more equilibrated relationship of respect. However, the lack of a standard legal framework has left room for subjective interpretations and variable implementation. The recent widespread concessioning of pristine ecosystems to mining industries in Ecuador has set up an unprecedented conflict and test of these rights. Currently, a landmark case involving Los Cedros Protected Forest and mining companies has reached the Constitutional Court of Ecuador. If Ecuador’s highest Court rules in favor of Los Cedros and the Rights of Nature, it would set a legal precedent with enormous impact on biological conservation in Ecuador and, potentially, the world. Such a policy shift offers a novel conservation strategy, through citizen oversight and action.

Introduction: The imbalance between technological development and ideological strengthening has resulted in the fading of the Pancasila ideological values of millennials. Technology that accompanies everyday life seems to be the main character in human life. Yet if humans themselves do not use technology wisely, technology can be a threat to both individuals and the life of the nation and state. If technology is increasingly out of control, threats to the Pancasila ideology are very likely to occur, such as in the G 30S PKI incident. Therefore, it is necessary to take action both from the government and the community as individuals to safeguard the development of technology to be used wisely. That way, we can prevent the threat to the Pancasila ideology together. Writing this article aims to analyze how the role and influence of the Pancasila ideology on the millennial generation in the 4.0 industrial revolution and to find solutions so that the values of Pancasila remain attached to the next generation of the Indonesian nation. Method: Writing This article uses a qualitative method by using literature reviews from the results of related research journals that have been published online through websites and other online media. Results: Thirteen journals and one book have met the criteria for the inclusion of a predetermined review. Research is based on the stigma of society regarding technological developments in the Industrial revolution 4.0. Therefore, the government is expected to be more severe in implementing human capital management. Conclusion: By procuring human capital management, it will be possible that Human Resources (HR) in Indonesia will be able to carry out the ideals of a golden Indonesian generation with Pancasila values inherent in the hearts of the people and the nation's future generations.

With COVID-19 vaccines slowly being rolled out in many countries, it is important to understand the public’s acceptance of being vaccinated. This study aims to study the willingness and motivations among residents of the cities of Caloocan, Malabon, and Navotas, Philippines to be vaccinated against COVID-19. Based on an online survey of 137 respondents, who willingly participated in the study, 71% will take a COVID-19 vaccine if it becomes available, with similar rates among respondents from Caloocan (82%), Malabon (83 %), and Navotas (81%). If a vaccine is proven safe and effective, more respondents (82%) will take a COVID-19 vaccine. Furthermore, safety against COVID-19 as well as the safety and effectiveness of vaccines are the primary factors why respondents are willing or unwilling to get a vaccine. The results highlight the need for effective messaging that promotes COVID-19 vaccination, with emphasis on the safety and effectiveness of the vaccine, and its benefits to the public, especially that the vaccines that will be delivered in the country in the next few months are not the most preferred brands by the respondents.

This paper analyses the health and performance of 12-stage axial compressor of the TV3-117VM/VMA turboshaft operated in a desert environment. The results of the dimensional control of 4,800 worn blades are analysed to model the wear process. Operational experience and numerical simulations are used to assess the effectiveness of an Inlet Particle Separator. Numerical modal analysis is performed to generate the Campbell diagram of worn blades and identify resonant blade vibration which can lead to high cycle fatigue (HCF). It is shown that the gradual loss of the stall margin over time determines the serviceability limits of compressor blades. Recommendations setting out go / no-go criteria are made to maintenance and repair organisations.

This study aims to model grinding of a Polish slag and evaluate the particle size distributions of the products obtained after different grinding times. Then, selected products were alkali activated in order to investigate the effect of particle size on the compressive strength of the produced alkali activated materials (AAMs). Other parameters affecting alkali activation, i.e. temperature, curing and ageing time were also examined. Among the different mathematical models used to simulate the particle size distribution, Rosin-Rammler (RR) was found to be the most suitable. When piecewise regression analysis was applied to experimental data it was found that the particle size distribution of the slag products exhibits multi fractal character. In addition, grinding of slag exhibits non-first-order behavior and the reduction rate of each size is time dependent. The grinding rate and consequently the grinding efficiency increases when the particle size increases, but drops sharply near zero after prolonged grinding periods. Regarding alkali activation, it is deduced that among the parameters studied, particle size (and the respective specific surface area) of the raw slag product and curing temperature have the most noticeable impact on the compressive strength of the produced AAMs.

In this paper, we study sums of finite products of Chebyshev polynomials of the first kind and Lucas polynomials and represent each of them in terms of Chebyshev polynomials of all kinds. Here the coefficients involve terminating hypergeometric functions ₂F₁ and these representations are obtained by explicit computations.

The aim of this work is to evaluate the impact of proposed modifications to conventional capturing and discharging effluents devices in Subsurface Flow Wetland (SSFW) systems. Main modifications proposed consist on extending the influence of the capture and discharge device in such a way that the SSFW width and height are fully covered. Additionally an SSFW prototype was built as pilot including the proposed modifications and the impact of the innovative device is measured based on the efficiency of the Chemical Oxygen Demand (COD) removal as compared to a traditionally built SSFW. The results show that for the innovative device, the COD removal was 10% higher than for the conventional device.

In recent years, nocturnal ozone enhancement(NOE) events have become a hot research topic in the field of atmospheric environment. By using statistically-based data analysis, we made a comparative investigation about nocturnal ozone concentrations and NOE events in 2022 and 2023, and further explored the effects of NOE events on O3 and PM2.5 at the night of the same day and the next day. The results showed that from 2022 to 2023 in Dongying, the annual average nocturnal ozone concentrations increased from 51 μg/m3 to 59 μg/m3, and the frequency of NOE events was higher in spring, summer and autumn, and lower in winter. NOE events not only had an obvious promoting effect on nocturnal O3 and Ox, and the daily maximum 8 h average concentration of O3 (MDA8-O3) of the same day (more apparent in summer and autumn), and nocturnal PM2.5 and PM2.5-bounded NO3- and SO42- (more apparent in winter), but also had a distinct influence on O3, Ox and MDA8-O3 of the next day (more apparent in summer). The results could strengthen the understanding of the phenomena of NOE events, and provide a scientific basis for the collaborative control of PM2.5 and ozone in urban areas in the Yellow River Delta, China.

This study aimed to understand the status of knowledge, attitudes, and practices (KAP) of norovirus infection among primary and junior middle school students in Chizhou City, explore its influencing factors. A multistage stratified random sampling method was used to randomly select 1200 students from 8 primary and junior middle schools for the effective questionnaire survey in Chizhou City. A multivariate logistic regression analysis was used to analyse the possible influencing factors. Of 1176 participants, the average knowledge score of norovirus infection was (9.8 ± 3.6), and the scoring rate was 65.3%. The average attitude score was (11.6 ± 1.2), and the scoring rate was 96.3%. The average practice score was (10.4 ± 1.5), and the scoring rate was 86.9%. The difference in the average scoring rate among the three was statistically significant (P < 0.001). The four independent variables of county, education level, sex and age group statistically correlated with the knowledge score. Primary and junior middle school students in Chizhou City had a good attitude and practice compliance in the prevention and control of norovirus infection; however, their professional knowledge still needed further improvement.

A cosmological model described by the perturbation metric is proposed, in which space is entrained by matter expanding as a result of the Big Bang. In the absence of an input of external energy and momentum, the solution of the Einstein equations assumes a pressure equal to zero and an accelerated expansion. The cosmological perturbation model explains the difference in measurements of the Hubble constant using gravitational lensing and a distance ladder.

Cuffless sphygmomanometers may be useful alternative blood pressure monitors for screening and home healthcare. The main requirements for these devices are accuracy in the resting state, accuracy during dynamic blood pressure changes, and long-term stability. Intermittent measurements can ensure that the accuracy of active measurements mirrors that of measurements in the resting and dynamic states. This brief report proposes a new protocol to evaluate long-term stability based on a comparison with a medically approved cuff-based automated sphygmomanometer rather than an auscultatory sphygmomanometer. Dynamic changes in blood pressure are not usually assessed based on intermittent measurement with an over-the-counter (OTC) sphygmomanometer. Thus, validation testing focused on the accuracy of the OTC cuffless sphygmomanometer in the resting state and the long-term stability of the device, and the results were similar to those of the cuff-based sphygmomanometer. Further research and discussions are necessary to develop standards derived from high-quality evidence for manufacturers of OTC sphygmomanometers.

I deduce an exact and analytic Bianchi type I solution of Einstein’s field equations which generalizes the isotropic ΛCDM universe model to a corresponding model with anisotropic expansion. The main point of the article is to present the anisotropic generalization of the ΛCDM universe model in a way suitable for investigating how anisotropic expansion modifies observable properties of the ΛCDM universe model. Although such generalizations of the isotropic ΛCDM universe model have been considered earlier, they have never been presented in this form before. Several physical properties of the model are pointed out and compared with properties of special cases such as the isotropic ΛCDM universe model. The solution is then used to investigate the Hubble tension. It has recently been suggested that that the cosmic large scale anisotropy may solve the Hubble tension. I consider those earlier suggestions and find that the formulae of these papers lead to the result that the anisotropy of the cosmic expansion is too small to solve the Hubble tension. Then I investigate the problem in a new way, using the exact solution of the field equations. This gives the result that the cosmic expansion anisotropy is still too small to solve the Hubble tension in the general Bianchi type I universe with dust and LIVE (Lorentz Invariant Vacuum Energy with a constant energy density which is represented by the cosmological constant) and anisotropic expansion in all three directions – even if one neglects the constraints coming from the requirement that the anisotropy should be sufficiently small, so that it does not have any significant effect upon the results coming from the calculations of the comic nucleosynthesis during the first ten minutes of the universe. If this constraint is taken into account, the cosmic expansion anisotropy is much too small to solve the Hubble tension.

The question of whether the early visual cortex (EVC) is involved in visual mental imagery remains a topic of debate. In this paper, I propose that the inconsistency in findings can be explained by the unique challenges associated with investigating EVC activity during imagery. During perception, the EVC processes low-level features which means that activity is highly sensitive to variation in visual details. If the EVC has the same role during visual mental imagery, any change in the visual details of the mental image would lead to corresponding changes in EVC activity. Within this context, the question should not be whether EVC is ‘active’ during imagery but how its activity relates to specific imagery properties. Studies using methods that are sensitive to variation in low-level features reveal that imagery can recruit the EVC in similar ways as perception. However, not all mental images contain a high level of visual details. Therefore, I end by considering a more nuanced view which states that imagery can recruit the EVC, but that does not mean that it always does so.

We show succinctly a natural origin of the beautiful Gamma function in light of the WJ distribution, linking to quite distinct fields.

The paper analyzes the probability distribution of the occupancy numbers and the entropy of a system at the equilibrium composed by an arbitrary number of non-interacting bosons. The probability distribution is derived both by tracing out the environment from a bosonic eigenstate of the union of environment and system of interest (the empirical approach) and by tracing out the environment from the mixed state of the union of environment and system of interest (the Bayesian approach). In the thermodynamic limit, the two coincide and are equal to the multinomial distribution. Furthermore, the paper proposes to identify the physical entropy of the bosonic system with the Shannon entropy of the occupancy numbers, fixing certain contradictions that arise in the classical analysis of thermodynamic entropy. Finally, by leveraging an information-theoretic inequality between the entropy of the multinomial distribution and the entropy of the multivariate hypergeometric distribution, Bayesianism of information theory and empiricism of statistical mechanics are integrated into a common ''infomechanical'' framework.

In the modern era of genomic research, the scientific community is witnessing an explosive growth in the volume of published findings. While this abundance of data offers invaluable insights, it also places a pressing responsibility on genetic professionals and researchers to stay informed about the latest findings and their clinical significance. Genomic variant interpretation is currently facing a challenge in identifying the most up-to-date and relevant scientific papers, while also extracting meaningful information to accelerate the process from clinical assessment to reporting. Computer-aided literature search and summarization can play a pivotal role in this context. By synthesizing complex genomic findings into concise, interpretable summaries, this approach facilitates the translation of extensive genomic datasets into clinically relevant insights. To bridge this gap, we present VarChat (varchat.engenome.com), an innovative tool based on generative AI, developed to find and summarize the fragmented scientific literature associated with genomic variants into brief yet informative texts.VarChat provides users with a concise description of specific genetic variants, detailing their impact on related proteins and possible effects on human health. Additionally, VarChat offers direct links to related scientific trustable sources, and encourages deeper research. Availability: VarChat is freely available at varchat.engenome.com

Serine/threonine kinase (AKT) signaling regulates diverse cellular processes and is one of the most important aberrant cell survival mechanisms associated with tumorigenesis, metastasis, and chemoresistance. Targeting AKT has become an effective therapeutic strategy for the treatment of many cancers. AKT3 (PKBγ), the least studied isoform of the AKT family, has emerged as a major contributor to malignancy. AKT3 is frequently overexpressed in human cancers, and many regulatory oncogenic or tumor suppressor small non-coding RNAs (ncRNAs), including microRNAs (miRNAs), have recently been identified to be involved in regulating AKT3 expression. Therefore, a better understanding of regulatory miRNA/AKT3 networks may reveal novel biomarkers for diagnosis of patients with cancer and provide invaluable information for developing more effective therapeutic strategies. The aim of this review is to summarize current research progress in the isoform-specific functions of AKT3 in human cancers and the roles of dysregulated miRNA/AKT3 in specific types of human cancers.

Accretionary and collisional orogeny are often accompanied by the disturbance of the geothermal gradient, leading to high-temperature metamorphism. High-temperature metamorphic rocks are significant in their ability to help the reconstruction of the thermal histories of orogenic belts. The Tianshan Orogenic Belt, at the southwest margin of the Central Asian Orogenic Belt, is a record of the long-term subduction–collision–post-collision orogenic process that has taken place in the Phanerozoic Eon. Here, we report the discovery of mafic granulites in the Muzhaerte area, SW Tianshan. Petrographic observation reveals that the mafic granulites underwent two metamorphic stages. The peak mineral assemblages of the first stage are dominated by clinopyroxene + orthopyroxene + plagioclase + quartz + hornblende ± biotite, and the post-peak mineral assemblages of the second stage are dominated by clinopyroxene + plagioclase + quartz + amphibole + biotite. The calculated results obtained from the two-pyroxene thermobarometers and the Al-in-hornblende barometer for the mafic granulites indicate that the metamorphic conditions of mafic granulites are 760–860 ℃ and < 0.39–0.41 Gpa. The mafic granulites recorded a high-grade granulite facies thermal metamorphic event with the highest temperature limit currently recorded in the Central Tianshan Block.

Fire-related cues could alter vegetation community composition by promoting or excluding different types of plants. Smoke-derived compounds have been a hot topic in plant and crop physiology. There are some fire-prone areas in Australia, both Americas, some Mediterranean countries and regions with extensive prescribed or illegal burning like central European, which are subjected to a direct impact of fire (heat, minerals accumulation from the burning matter) and/or the indirect one (smoke) and undergo compositional and structural changes. This review first updates information about the effect of the compounds on plants' kingdoms and focuses on the research advances in the field of smoke compounds and attempts to gather and summarize the recent state of research and opinions on the role of smoke-derived compounds in plants' lives. We finish our review by discussing major research gaps, which include: Why plants respond to smoke chemicals? Is the response of seeds to smoke and smoke compounds an evolutionary-driven trait allowing plants to adapt to local environment?

An attempt has been made to explore the relative contributions of moisture feedback processes on tropical intraseasonal oscillation or Madden Julian Oscillation (MJO). We focused on moisture feedback processes, including evaporation wind feedback (EWF) and moisture convergence feedback (MCF), which integrates the mechanisms of convective interactions in the tropical atmosphere. The dynamical framework considered here is a moisture-coupled, single-layer linear shallow-water model on an equatorial beta-plane with zonal momentum damping. With this simple approach, we aimed to recognize the minimal physical mechanisms responsible for the existence of the essential dispersive characteristics of the MJO, including its eastward propagation(k>0), the planetary-scale (small zonal wavenumbers) instability, and the slow phase speed of about ≈ 5 m/sec. Further, we extended our study to determine each feedback mechanism’s influence on the simulated eastward dispersive mode. Our model emphasized that the MJO-like eastward mode is a possible outcome of the combined effect of moisture feedback processes without requiring additional complex mechanisms such as cloud radiative feedback and boundary layer dynamics. The results substantiate the importance of EWF as an energy source for developing eastward moisture mode with a planter-scale instability. Moreover, our model endorses that the MCF alone could not produce instability without surface fluxes, although it has a significant role in developing deep convection. It is found that the MCF exhibits a damping mechanism by regulating the frequency and growth rate of the eastward moisture mode at shorter wavelengths.

The aims of this paper are 1) to explore the type of industry of SMEs that can survive for more than 5 years in ASEAN, and 2) to analyze the success factors of SMEs in ASEAN to be able to survive for more than 5 years. This paper employs a qualitative method, with a literature review and meta-analysis. From 2007 to 2017, data was extracted from Google Scholar, Emerald Insight, Sage Pub, and EBSCO databases. There are 14 factors that influence the success of SMEs in the main sectors, 20 factors in the manufacturing sectors, and 14 factors in the service sectors, depending on the type of industry. For instance: eCommerce, technology, and social media, international oriented, good management system, government support, working condition /environment, skill and competency labour/owner, market penetration/selection, policy, organizational performance, and characteristics, networking with government /supplier / customer, networking with government /supplier /customer, planned /strategy (business /market /operational /organizational). The findings of this literature review reveal several important factors that are critical to the success of SMEs in competing with other industries and can be developed for a longer period.

Cancer patients may experience significant distress. The “Emotion Thermometers” (ETs) are a short visual analogue scale used to screen patients for psychosocial risk. This study aimed to assess emotional distress in a large sample of cancer patients attending psychological services at an NGO, and to explore factors that may contribute to it. The ETs were answered by 899 cancer patients. They were, on average, 59.9 years old, the majority were female, had breast cancer, were under treatment or were disease-free survivors, and reported high levels of emotional distress, above the cut-off (≥5). A Generalized Linear Model was used to measure the association between the level of Distress and 33 items of the problem list. Four items - sadness, depression, sleep and breathing - were found to be significantly related to a higher level of Distress. Additionally, women and those who were in the palliative phase also had significantly higher levels of Distress. Conclusions: The results confirm the need for early emotional screening in cancer patients, as well as the relevance of attending to the characteristics of each patient. Additionally, they highlight the utility of the ETs for the clinical practice, allowing to optimize the referral to specialized psy-chosocial services.

This comprehensive study focused on the standard taxi sign used in Ireland, its impact on drag production, fuel expenses, and CO2 emissions. Experimental analysis revealed that the conventional taxi sign significantly increased drag, especially when mounted on streamlined vehicles such as saloon cars, due to flow separation issues on the rear roof and rear windshield. Longitudinal reorientation of the sign offered a 14-fold reduction in drag increase compared to the traditional placement. It was found that positioning the sign in the middle of the roof offered the greatest fuel efficiency. Furthermore, the study estimated that implementing longitudinal repositioning on all Irish taxi signs could save drivers approximately 832 per year and reduce national CO2 emissions by a substantial 22,464 tonnes annually. Comparative analyses with international taxi signs demonstrated that the Irish sign had significantly larger drag contributions, emphasizing the need for improved aerodynamics. To address the inherent drag issue, the study explored novel appendable devices and proposed alternative taxi sign designs. Among the tested solutions, a magnet-mounted front ramp proved the most effective, reducing total drag by nearly 30%. Additionally, a motorized flip-up taxi sign design demonstrated a remarkable 40% reduction in drag. Finally, a newly proposed taxi sign design, featuring longitudinal positioning and pointed triangular front and rear faces, resulted in a minimal 4.3% increase in vehicle drag compared to the baseline car.

A rigid protruding surface, agitator and vortex generator often dissipate more energy than to produce a satisfied turbulence production. In contrast, a passively-oscillating flexible protruding surface has the ability in generating greater turbulence level. In the current study, a circular finite cylinder (cantilever) was used as the geometry of the rigid and protruding surface. They were varied through the aspect ratio (AR) and materials. Also, a local Reynolds number within the subcritical flow range (102<ReD<105) was considered. The results from the rigid protruding surface (finite cylinder) is served as a validation to the published results and benchmark to the improve-ment of the turbulence generated by the flexible protruding surface. It was mentioned in the pre-vious work that the increment of turbulence production by the flexible cylinder is speculated to be oscillation, this work investigates the validity of the speculation through manipulating the struc-tural stiffness of the flexible cylinder by employing different materials. The results have further demonstrated that the flexible cylinder is capable of generating a greater turbulence through the examination of turbulence intensity, turbulence production term and Reynolds stress. All the flex-ible cylinders that oscillate show increment in turbulence production but at a different percentage. The cylinders studied in this work ranged from the least structural stiffness (EVA), moderate (al-uminium) to the highest structural stiffness (carbon steel). Through studying the normalized am-plitude responses graph of the flexible cylinder, it is identified that the oscillating motion does in-deed contribute to increment. A further investigation into the results, it is found that the factor which governs the increment is the structural velocity instead of just oscillating motion alone.

Evolutionary theory suggests that the origin, persistence, and evolution of biology is driven by the “natural selection” of characteristics improving the differential reproductive success of the organism in the given environment. The theory, however, lacks physical foundation, and, therefore, at best, can only be considered a heuristic narrative, of some utility for assimilating the biological and paleontological data at the level of the organism. On deeper analysis, it becomes apparent that this narrative is plagued with problems and paradoxes. Alternatively, non-equilibrium thermodynamic theory, derived from physical law, provides a physical foundation for describing material interaction with its environment at all scales. Here we describe a “natural thermodynamic selection” of characteristics of structures (or processes), based stochastically on increases in the global rate of dissipation of the prevailing solar spectrum. The different mechanisms of thermodynamic selection are delineated for the different biotic-abiotic levels, from the molecular level at the origin of life, up to the level of the present biosphere with non-linear coupling of biotic and abiotic processes. At the levels of the organism and the biosphere, the non-equilibrium thermodynamic description of evolution resembles, respectively, Darwinian and Gaia descriptions, although the underlying mechanisms and the objective function of selection are fundamentally very different.

Climate change is an issue that is the order of the day, and among the many consequences it has on the environment one is its influence on the amount and frequency of rainfall on our planet, since our water supply depends on them. Therefore, in order to quantify these effects, a rainfall analysis has been carried out using data collected in Bilbao over the last 150 years. Thanks to this, it has been possible to observe that, although the total annual amount seems to suffer a slight decrease, hardly quantifiable with certainty, it is true that the intra-annual patterns are more concentrated at certain times of the year, with greater imbalances between one month and another than in previous years. However, taking into account the capacity of the reservoirs that supply the Greater Bilbao area, it can be concluded that this does not pose any problem for Bilbao's supply, at least at present.

Modern commercial air travel connects disparate human populations with the global airline industry transporting up to 4.5 billion passengers annually in the years leading up to the COVID-19 pandemic. While such connections are convenient for commerce and tourism, air travel networks can also be efficient distributors of infectious diseases such as influenza, SARS-CoV-1, hemorrhagic fevers, and more recently SARS-CoV-2 and monkeypox. During the COVID-19 pandemic, public health agencies used multi-layered control strategies including pre-departure testing and vaccination requirements, masking, post-arrival testing, and quarantine to manage the risk of COVID-19 transmission associated with air travel. Simultaneously, the surveillance of aircraft wastewater emerged as a promising new data source to screen for SARS-CoV-2 infections, including newly emergent lineages, among international air travelers. Herein, we review the potential of aircraft wastewater for public health surveillance. The known contributing population and flight itinerary combined with the highly concentrated waste stream and convenient sampling during routine lavatory servicing make aircraft wastewater a strategic opportunity for unintrusive surveillance of the global fluxes of human pathogens. We estimate for the cases of fecal- or urine-shed pathogens, sampling from 3,500 and 1,250 flights per week, respectively, would be required to survey 10% of all global long-haul flight passengers. In the case of the United States, achieving 10% coverage of all international arrivals would require sampling from 925 and 322 flights per week, respectively. Aircraft wastewater surveillance could also be integrated with network and infectious disease models to better inform traditional public health control measures during emerging epidemics. Given the tremendous potential for public good and the massive economic costs of epidemics, governments should consider international collaboration to create a global aircraft wastewater surveillance system.

We analyze the question of GDP Growth-GDPG rate in the context of Environmental, Social and Governance-ESG framework. We use World Bank data for 193 countries in the period 2011-2020 using different econometric techniques i.e., Panel Data with Fixed Effects, Panel Data with Random Effects, Pooled Ordinary Least Squares-OLS. We found that GDPG rate is positively associated, among others, to “Government Effectiveness” and “Prevalence of Undernourishment” and negatively associated among others to “Unemployment” and “Research and Development Expenditure”. Furthermore, we have applied the k-Means algorithm optimized with the Elbow method and we found the presence of four clusters in the sense of GDPG rate. Finally, we confront eight machine learning algorithms to predict the value of GDPG rate and we found that the Polynomial Regression is the best predictor. The Polynomial Regression predicts an increase of GDPG rate equal to 2.88% on average for the analysed countries.

One of the most extensively studied topics in dozens of studies is the alteration process of ilmenite, the formation of leucoxene and the presence of some impurity oxides; SiO2 and Al2O3. The altered Egyptian black sand ilmenite grains of relatively lower magnetic characters are studied using the binocular microscope and the Cameca SX-100 microprobe instrument. Both of individual brown and black altered grains separated at 0.5 and 1 ampere values are investigated. The detection of the Various alteration phases, the mechanism of formation, their molecular formulas &amp; limits, and the role of SiO2&amp;Al2O3 in alteration mechanisms are detected. The alteration phases includes: pseudorutile (psr) and leached pseudorutile (lpsr) of different phases in addition also to rutile. Few analyzed spots are detected to be leached ilmenite (lilm). Several Excel softwares are adopted to calculate the chemical formulas of each alteration phase. The contents of TiO2 and Fe2O3 of all the investigated psr-lpsr in the study range between 59.16-86.56%, and 37.3-6.68%, respectively. The Ti/(Ti+Fe) ratio for these formulas ranges between 0.60 and 0.88. The psr-lpsr chemical formulas of all the investigated grains range as follows: Fe2.01-0.50Ti3O8.97-4.50(OH)0.03-4.50 . The concluded lowest cationic iron content of the well defined accepted lpsr phase is 0.5 with a corresponding molecular formula of Fe0.50Ti3O4.5(OH)4.5. It was concluded that in the region of 68-70 TiO2%, the mechanism of ilmenite alteration may be changed where neither all the analyzed TiO2 of the spot nor all the calculated structural water are contained within the molecular formula of lpsr. There are other associated mineral phases containing for some TiO2 and also some structural water which most probably are removed from the lpsr phase. As the analyzed spots are located at highly fissured locations, as the alteration process is relatively faster and the lpsr phase can be broken into rutile and hematite. Also, as the analyzed TiO2 and structural and/or molecular water contents increase, as the darkness of the BSE image areas of the grain increases; this may reflect the existence of an individual TiO2 phase; most probably rutile, mixed in homogeneity with the existed lpsr component. As the content of TiO2 increases; within a definite TiO2 range (80-85%), as the associated contents of Al2O3&amp;SiO2 increase. When the contents of the structural and/or molecular water contained within the lpsr phases decreases; the sum total oxides is more than 98%, the contents of Al2O3 are highly depleted. In the late alteration stages, the lpsr structure does not suddenly collapse but gradually producuing other associated mineral phases. The relatively enriched contents of SiO2 and/or Al2O3 in some secondary rutile grains can be explained as most of the SiO2% is associated with mol water or bearing for mol and/or str water necessary for the leachability of Fe3+ from the psr structure. The XRD patterns of the investigated grains before and after roasting at 1100 oC for one hour are detected and interpreted.

Healthcare systems are mindful of the importance of proper diet and nutrition in reducing the risk of various chronic diseases resulting in hospitalizations. In this regard, they are focusing on promoting the intake of foods comprising various diets with health benefits, such as the ketogenic diet. In this meta-analysis, a total of 20 research studies on the effect of the ketogenic diet on the immune system were analyzed. The research studies were obtained from three databases: Google Scholar, PubMed, and Science Direct. From the meta-analysis, the odd ratio of a similar outcome of an improvement in the strength of immunity between the intervention and control group was 0.76. On the other hand, the p-value for the studies was 0.09, with 15 out of the 20 being considered statistically significant. The heterogeneity between the studies was I2 = 15%, signifying a low variability in the findings that is not by chance. The Ketogenic diet indeed has positive effects on immunity. Nonetheless, it can also result in negative effects that may harm human health.

Monkeypox virus (MPXV), causing zoonotic diseases in humans, is a member of Orthopoxvirus under Poxviridae family. The virus was first reported in monkeys in 1959 in Denmark and in humans in 1970 in the Congo. Outside Africa, the virus first appeared in the USA in 2003 and since then occurred sporadically. The virus reemerged in 2017 and now spreading globally. African wild rodent mammals are thought to be the reservoir of MPXV. Exotic trade of animals and international travel favors the dissemination of MPXV. Genetic analysis shows two clades of the MPXV. Smallpox vaccine shows cross-protection and people who never in contact with Orthopoxvirus affected more than exposed ones. Fever, muscle pain, headache, and vesicle formation are the dominant clinical sign. Guarnieri-like inclusions and Ballooning degenerations are important pathognomic lesion of MPXV. It may produce case fatality rate up to 11%. Genetic materials alterations may favor the reemergence of the virus. The continuing occurrence over 73437 cases in 109 countries shows that MPXV can spread among humans competently and can be a serious issue of global public health concern. Here, we summarize the existing knowledge about re-emergence and insights into MPXV which will be of useful to curb its occurrence.

How important are institutions for the development of nations? Are there any existing measures which quantify the behavior of institutions? Is there any theoretical justification for measuring their behavior? This paper introduces a framework influenced by Plato’s needs theory to provide justification for measuring the behavior of institutions. This involves introducing the humanization hypothesis which states that the behavior of institutions can be measured as they, similar to human beings, are living entities with similar hierarchical needs which are essential for their survival. The paper employs an explanatory and descriptive research design which is highly theoretical in nature.

As a typical form of value co-creation, crowdsourcing has been increasingly applied by firms to generate business value. By engaging a crowd, a platform, and other stakeholders, a crowdsourcer can foster the co-creation of a portfolio of value for diverse stakeholders. In analyzing the value co-creation in crowdsourcing, we propose a framework by combining the theories and frameworks in value co-creation and crowdsourcing. The framework examines the key stakeholders, joint purpose, engaged value co-creation processes, contributions, bidirectional relationships of the engagement, and perceived value, exhibiting a holistic view of the value co-creation in a crowdsourcing project. Results of the analysis reveal the business performance of the crowdsourcing project and identify areas of improvement regarding business sustainability. This is a major theoretical contribution of this study. The research design applied a case study approach to empirically investigate a crowdsourcing project. Both the theoretical and practical implications are discussed.

Since the process of waste recycling generates dust and flammable gas during fragmentation, there is always a risk of fire resulting therefrom, and fire does, in fact, frequently occur. However, research on disaster management at recycling facilities deals only with the problem of processing systems from a technical point of view, but it does not suggest concrete alternatives from a management point of view. Therefore, in this study, we analyzed the influence of the disaster response network of a waste recycling center at the organizational level based on the concept of the cognitive accuracy of a network when considering administrative aspects. Through this analysis, we confirmed that factors affecting the influence of the network exist, such that the entire network and the networks of different levels of position are different. We suggest that this can be improved by deploying members who perform formal tasks at the center of the network so that everyone can agree political approach.

If the development of machine learning and artificial intelligence plays a role in many fields of research and technology today, it has a special relationship with neurosciences. Indeed, historically inspired by our knowledge of the brain, deep learning shares some vocabularies with neurosciences and can sometimes be considered a brain’s model. Taking the particular example of epileptic seizure, which can develop in any biological neural tissue, we raise the question if and how the models used for deep learning can capture or model these pathological events. This particular example is a starting point to discuss the nature, limits, and functions of these models, and what we expect from a model of the brain. Finally, we argue that a pluralistic approach leading to the integrated coexistence of different models is necessary to study the brain in all its complexity.

Based on the textured controllable interface effect, the dynamic performances of the textured and ordinary pilot valve are analyzed experimentally, and the influence of the textured controllable interface on the response of pilot valve is studied. Results show that when Pin is small, the textured surface shortens the reciprocating time of valve core, increasing the flow rate, and speeds up the piston stroke of oil cylinder. The valve core actions much more stable and sensitivity. Meanwhile, combined with the theoretical calculation, the operation mechanism of texturing the pilot valve is analyzed. It is concluded that the stress of textured valve core sealing surface is greater than that of ordinary one, and the pressure difference gradually decreases with the increase of Pin, and the flow difference is basically the same as the force on the sealing surface. This indicates that the textured surface improves lubrication characteristics, reduces the friction between components. The textured valve makes the velocity changes gently, and enhances the responsiveness and stability of the valve. Those related results provide a new idea for enhancing the response design of the pilot valve.

The neural-crest derived enteric nervous system (ENS) is the intrinsic nervous system of the gastrointestinal (GI) tract and controls all gut functions, including motility. Lack of ENS neurons causes various ENS disorders such as Hirschsprung Disease. One treatment option for ENS dis-orders includes the activation of resident stem cells to regenerate ENS neurons. Regeneration in the ENS has mainly been studied in mammalian species using surgical or chemically-induced injury methods. These mammalian studies showed a variety of regenerative responses with generally limited regeneration of ENS neurons, but (partial) regrowth and functional recovery of nerve fibers. Several aspects might contribute to the variety in regenerative responses, including observation time after injury, species, and gut region targeted. Zebrafish have recently emerged as a promising model system to study ENS regeneration as larvae possess the ability to generate new neurons after ablation. As the next steps in ENS regeneration research, we need a detailed under-standing of how regeneration is regulated on a cellular and molecular level both in animal models with high and low regenerative capacity. Understanding the regulatory programs necessary for robust ENS regeneration will pave the way for using neural regeneration as a therapeutic approach to treating ENS disorders.

Energy system modelling is an essential practice to assist a set of heterogeneous stakeholders in the process of defining an effective and efficient energy transition. From the analysis of a set of open source energy system models, it has emerged that most models employ an approach directed at finding the optimal solution for a given set of constraints. On the contrary, a simulation model is a representation of a system that is used to reproduce and understand its behaviour under given conditions, without seeking an optimal solution. Given the lack of simulation models that are also fully open source, in this paper a new open source energy system model is presented. The developed tool, called Multi Energy Systems Simulator (MESS), is a modular, multi-node model that allows to investigate non optimal solutions by simulating the energy system. The model has been built having in mind urban level analyses. However, each node can represent larger regions allowing wider spatial scales to be be represented as well. MESS is capable of performing analysis on systems composed by multiple energy carriers (e.g. electricity, heat, fuels). In this work, the tool’s features will be presented by a comparison between MESS itself and an optimization model, in order to analyze and highlight the differences between the two approaches, the potentialities of a simulation tool and possible areas for further development.

Polyaromatic hydrocarbons (PAHs) are widespread in the interstellar medium (ISM). The abundance and relevance of PAHs call for a clear understanding of their formation mechanisms, which, to date, have not been completely deciphered. Of particular interest is the formation of benzene, the basic building block of PAHs. It has been shown that ionization of neutral clusters can lead to an intra-cluster ionic polymerization process that results in molecular growth. Ab initio molecular dynamics (AIMD) studies in clusters consisting of 3–6 units of acetylene modeling ionization events under ISM conditions have shown maximum aggregation of three acetylene molecules forming bonded C6H6+ species: the larger the number of acetylene molecules, the higher the production of C6H6+. These results lead to the question of whether clusters bigger than those studied thus far promote aggregation beyond three acetylene units, and whether larger clusters can result in higher C6H6+ production. In this study, we report results from AIMD simulations modeling the ionization of 10 and 20 acetylene clusters. The simulations show aggregation of up to four acetylene units producing bonded C8H8+. Interestingly, C8H8+ bicyclic species were identified, setting precedent for their astrochemical identification. Comparable reactivity rates were shown with 10 and 20 acetylene clusters.

The Haar wavelet decomposition technique is used to detect the planetary magnetosphere boundaries and discontinuities. We use the magnetometer data from the CASSINI and MESSENGER spacecraft to identify the abrupt changes in the magnetic field when the spacecraft crossed the magnetospheric bow shocks and magnetopauses of Saturn and Mercury, respectively. The results confirm that the Haar transform can efficiently identify the planetary magnetosphere boundaries characterized by the abrupt magnetic field changes. It is suggested that this technique can be applied to detect the planetary boundaries as well as the discontinuities such as the shock waves in the interplanetary space.

Abstract: Green walls and green dams are increasingly being considered as part of many nation-al and international desertification initiatives. This paper studies the spatiotemporal evolution of the green dam in the Moudjbara region (Djelfa Province, Algeria) from 1972 to 2019 by using Landsat imagery, Land Change Modeler and Open Land package. The future evolution of pine plantations for the year 2029 was also forecasted, based on an anthropogenic scenario (i.e., an-thropogenic pressure is the main driver of the green dam destruction). Our findings revealed that the green dam project was successful for a few years, but after that, pine plantations deteri-orated significantly due to forest harvesting, livestock overgrazing, and the proliferation of the pine caterpillar processionary, which destroyed most of the reforestation. Land Change Modeler predicted a huge degradation of pine plantations for the year 2029, and if the deforestation con-tinues at the same rate, the green dam will disappear in the Moudjbara region during the next few decades. Aware of this threat, the Algerian authorities are now planning to reforest more than 1.2 million ha under the latest rural renewal policy by introducing new principles related to sustainable development, fighting desertification, and climate change adaptation

The brain rhythms are essential for information processing in neuronal networks. Oscillations recorded in different brain regions can be synchronized and have a constant phase difference, i.e. be coherent. Coherence between local field potential (LFP) signals from different regions in the brain may be correlated with the performance of cognitive tasks, from which it is concluded that these regions of the brain are involved in the task performance together. In this review, we discuss why coherence occurs and how it is coupled to the information transfer between different regions of the hippocampal formation. Coherence in theta and gamma frequency ranges is described since these rhythms are most pronounced during the hippocampus-dependent attention and memory. We review in vivo studies of interactions between different regions of the hippocampal formation in theta and gamma frequency bands. The kay provisions of the review: 1) coherence emerges from synchronous postsynaptic currents in principal neurons, occurring as a result of synchronization of neuronal spike activity; 2) synchronization of neuronal spike patterns in two regions of the hippocampal formation can be realised through induction or resonance; 3) coherence at a specific time point reflects the transfer of information between regions of the hippocampal formation, in particular, gamma coherence reflects the coupling of active neuronal ensembles. Overall, coherence is not an epiphenomenon, but an important physiological process that has certain generation mechanisms and performs important functions in information processing and transmission across the brain regions.

The mechanism by which the pigment melanin is transferred from melanocytes to keratinocytes to achieve skin pigmentation remains controversial. Several models emerged in the past decades to explain the transfer process. Here, we review the proposed models for melanin transfer in the skin epidermis, the available evidence supporting each one, and the recent observations made by ours and other groups in favor of the exo/phagocytosis and shed vesicles models. Moreover, we propose that different models could coexist to sustain skin pigmentation under different conditions. Finally, we discuss new questions that ought to be addressed to solve the long-lasting quest for the understanding of how basal skin pigmentation is controlled. This knowledge will allow the emergence of new strategies to treat pigmentary disorders that cause a significant socio-economic burden to patients and healthcare systems worldwide and could also have relevant cosmetic applications.

Background: The ongoing outbreak of Coronavirus Disease 2019 (COVID-19) represents a major threat to human health, which impairs the functionality of several organs. One of the hardest challenges in the fight against COVID-19 is the development of wide-scale, effective, and rapid laboratory tests to control disease severity, progression, and possible sudden worsening. Monitoring patients in real-time is indeed highly demanded in this pandemic era when physicians need reliable and quantitative tools to prioritize patients’ access to intensive care departments. In this regard, salivary biomarkers are extremely promising, as they allow for a fast and non-invasive specimens’ collection, which can be repeated multiple times. Methods: We compare salivary levels of immunoglobulin A subclasses (IgA1 and IgA2) and free-light chains (FLC k and λ) in a cohort of 29 SARS-CoV-2 patients and 21 healthy subjects. Results: We found that each biomarkers differs significantly between the two groups, with p-values ranging from 10-8 to 10-4. The performance ranking of these markers, shows that λFLC level (p=1.4e-8) is the best-suited candidate to discriminate the two groups, with an accuracy of 0.94 (0.87-1.00 95% CI), a precision of 0.91 (0.81-1.00 95% CI), a sensitivity of 1.00 (0.96-1.00 95% CI) and a specificity of 0.86 (0.70-1.00 95% CI). Conclusion: These results suggest λFLC as an ideal indicator of patient conditions. This is more strengthened in consideration that λFLC half-life (approximately 6 hours) is significantly shorter than the IgA one (21 days): thus λFLC appears displaying the potential to effectively monitor patients fluctuation in real-time.

Saliva has diverse functions in feeding behavior of animals. However, the impact of salivary digestion of food on insect gustatory information processing is poorly documented. Glucose-aversion (GA) in the German cockroach, Blattella germanica, is a highly adaptive heritable behavioral resistance trait that protects the cockroach from ingesting glucose-containing-insecticide-baits. In this study, we confirmed that GA cockroaches rejected glucose, but they accepted oligosaccharides. However, whereas wild-type cockroaches that accepted glucose also satiated on oligosaccharides, GA cockroaches ceased ingesting the oligosaccharides within seconds, resulting in significantly lower consumption. We hypothesized that saliva might hydrolyze oligosaccharides, releasing glucose and terminating feeding. By mixing artificially collected cockroach saliva with various oligosaccharides, we demonstrated oligosaccharide-aversion in GA cockroaches. Acarbose, an alpha-glucosidase inhibitor, prevented the accumulation of glucose and rescued the phagostimulatory response and ingestion of oligosaccharides. Our results indicate that pre-oral and oral hydrolysis of oligosaccharides by salivary alpha-glucosidases released glucose, which was then processed by the gustatory system of GA cockroaches as a deterrent and caused the rejection of food. We suggest that the genetic mechanism of glucose-aversion support an extended aversion phenotype that includes glucose-containing oligosaccharides. Salivary digestion protects the cockroach from ingesting toxic chemicals and thus could support the rapid evolution of behavioral and physiological resistance in cockroach populations.

An abdominal aortic aneurysm (AAA) is a dilatation of the abdominal aorta that progressively grows till the rupture. Treatment is typically recommended when the diameter is more than 5 cm. The EVAR (Endovascular aneurysm repair) is a mininvasive procedure that involves the placement of an expandable stent graft within the aorta to treat aortic disease without operating directly on the aorta. For years, stent grafts' essential design was based on metallic stent frames to support the fabric. More recently, a polymer-based technology has been proposed as an alternative method to seal AAA. This review underlines the two platforms that are based on a polymer technology: 1)the polymer-filled endobags, so-called Endovascular Aneurysm Sealing (EVAS) with Nellix stent graft; and 2)the O-ring EVAR polymer-based proximal neck sealing device, so-called Ovation stent graft. Polymer characteristics for this particular aim, clinical applications, and durability results are summarized and commented critically. The platform that embraced the concept of inflating endobags filled with polymer to exclude the aneurysmal sac was not successful because of the lack of an adequate proximal fixation. The platform that used polymer to create a circumferential sealing of the aneurysmal neck has proven safe and effective.

Land management and community involvement are two main elements in ensuring the absence of conflict between landowners and agencies. Disputes between owners and agencies will be the biggest obstacle in the land development effort. Therefore, this article aims to address the cause of landowners’ objections against land alienation using the institutional approach. To enable the researchers to understand the root causes of landowners' objections against the alienation of land using the Communal Grant method, the institutional approach has been adopted to identify the issue of the objection. Therefore, questionnaires for 100 landowners were distributed in two villages in Semporna district in Sabah. The purpose is to obtain their views on the cause leading to the dispute of land alienation using the Communal Grant method. The Likert scale was used to enable community rankings on issues that can be understood according to the level of seriousness of the population's views on the issue of using Communal Grants in native customary land alienation. The study results explain that there are four factors that drive objection of the Communal Grant land alienation which involves the formal factors. The findings explained that there are 4 formal provisions which lead to the community's objection against Communal Grants, namely the native customary lands (NCR) act, provision of Communal Grants, provisions in the land ownership and land allocation in Sabah Land Ordinance.Due to numerous objections among native customary peoples concerning the native customary land alienation using Communal Grants, the government has acted in substitution with a fair method of individual ownership for the native customary peoples. This situation explains that disputes in land ownership can be a threat to the country if it cannot be resolved in ways and methods acceptable to the native customary community. This study will benefit the government and NGO’s to alert and focusing on barriers in the context of local community land laws. Communal grants are intended to address land issues in Sabah.

Sedation is a ubiquitous practice in ICUs and NCCUs. It has the benefit of reducing cerebral energy demands, but also precludes an accurate neurologic assessment. Because of this, sedation is intermittently stopped for the purposes of a neurologic assessment, which is termed a neurologic wake-up test (NWT). NWTs are considered to be the gold-standard in continued assessment of brain-injured patients under sedation. NWTs also produce an acute stress response that is accompanied by elevations in blood pressure, respiratory rate, heart rate, and ICP. Utilization of cerebral microdialysis and brain tissue oxygen monitoring indicates that this is not mirrored by alterations in overall cerebral metabolism, and seldom affects oxygenation. The hard contraindications for the NWT are preexisting intracranial hypertension, barbiturate treatment, status epilepticus, and hyperthermia. However, hemodynamic instability, sedative use for primary ICP control, and sedative use for severe agitation or respiratory distress are considered significant safety concerns. Despite ubiquitous recommendation, it is not clear if additional clinically relevant information is gleaned through its use, especially with the contemporaneous utilization of multimodality monitoring. Various monitoring modalities provide unique and pertinent information about neurologic function, however, their role in improving patient outcomes and guiding treatment plans has not been fully elucidated. There is a paucity of information pertaining to the optimal frequency of NWTs, and if it differs based on type of injury. Only one concrete recommendation was found in the literature, exemplifying the uncertainty surrounding its utility. The most common sedative used and recommended is propofol because of its rapid onset, short duration, and reduction of cerebral energy requirements. Dexmedetomidine may be employed to facilitate serial NWTs, and should always be used in the non-intubated patient or if propofol infusion syndrome (PRIS) develops. Midazolam is not recommended due to tissue accumulation and residual sedation confounding a reliable NWT. Thus, NWTs are well tolerated in most patients and remain recommended as the gold-standard for continued neuromonitoring. Predicated upon one expert panel, they should be performed at least one time per day. Propofol or dexmedetomidine are the main sedative choices, both enabling a rapid awakening and consistent NWT.

Groundwater is a vital resource for human welfare. However, due to various factors, groundwater pollution is one of the main environmental concerns facing. Yet, it is challenging to simulate groundwater quality dynamics due to the insufficient representation of nutrient percolation processes in the soil and Water Assessment Tool model. The objectives of this study were extending the SWAT module to predict groundwater quality. The results proved a linear relationship between observed and calculated groundwater quality considering No3 and TDS with R2, NSE and PBIAS values in the satisfied ranges, albeit underestimation and overestimation were observed due to limited data availability. These results highlight that nitrate and TDS concentrations and variability in groundwater may used as a tool in surface water quality that have to be assumed for designing adaptive management scenarios. Hence, extended SWAT model could be a powerful tool for future regional to global scale modelling of nutrient loads supporting effective surface and groundwater management.

Of the roughly 20,000 canonical human protein sequences, as of September 15, 2020, 6,937 proteins have had their full or partial, medium- to high-resolution structures determined by x-ray crystallography or other methods. Which of these proteins dominate the Protein Data Bank (the PDB) and why? In this paper, we list the 273 top human protein structures based on the number of their PDB entries. This set of proteins accounts for more than 40% of all available human PDB entries and represent past trends as well as current status for protein structural biology. We briefly discuss the relationship which some of the prominent protein structures have with protein research as a whole and mention their relevance to human diseases. The top-10 soluble and membrane proteins are all well-known (most of their first structures being deposited more than 30 years ago). Overall, there is no dramatic change in recent trends in the PDB. Remarkably, the number of structure depositions has grown nearly exponentially over the last 10 or more years (with a doubling time of 7 yrs for proteins from all organisms). Growth in human protein structures is slightly faster (at 5.9 yrs, while E.Coli and Mouse+Rat protein structures accumulate more slowly, Zebrafish protein structures are growing most, at a doubling every 3.7 years, albeit starting from only approx. 100 structure entries in 2010). The information may be informative to senior scientists but also inspire researchers who are new to protein science, providing the year 2020 snap-shot for the state of protein structural biology.

The universal Debye – Mayer – Kelly hybrid model was proposed for the description of the heat capacity from 0 K to the melting points of substance within the experimental uncertainty for the first time. To describe the heat capacity, the in-house software on the base of commercial one DELPHI-7 was used with a 95% confidence level. To demonstrate the perfect suitability of this model, a thermodynamic analysis of the heat capacities of the fourth group elements, and some compounds of the A^IIIB^V and A^IIB^VI phases was carried out. It produced good agreement within the experimental uncertainty. There is no a similar model description in literature.The Similarity Method is a convenient and effective tool for critical analysis of the heat capacities of isostructural phases, which was used as an example for diamond-like compounds. Phases with the same sum of the atomic numbers of elements (Z), such as diamond and B_0.5 N_{0.5 (cub)} (Z = 6); pure silicon (Si) and Al_0.5 P_0.5 (Z=14); pure germanium (Ge) and Ga_0.5 As_0.5 (Z = 32)); pure grey tin (alpha-Sn) and In_0.5 Sb_0.5, and Cd_0.5 Te_0.5 (Z = 50) have the same heat capacity experimental values in the solid state. The proposed models can be used to both different binary and multicomponent phases. It helps to standardize the physicochemical constants.

With the continuous emergence and application of new technologies, the construction of smart cities has entered the practical promotion period. Since 2012, the pilot construction of smart city has been promoted by the government in China. On the basis of these practical experiences, this paper presents an overview of the latest technologies and applications for smart city construction in China and demonstrates that smart city strategy needs to be implemented according to local conditions, adhering to the people-oriented concept and using scientific and effective top-level design and planning. The construction of smart city is comprehensive system engineering, including the integration of geographic information sharing service platform, full-cycle management and control system of urban planning, construction and social management, as well as intelligent business information management system of gardening, water conservancy, environmental protection and other industries and departments. The information system (GIS), satellite remote sensing (SRS), global navigation satellite system (GNSS), Internet of things, mobile applications, cloud computing, visualization technology ware used to promote urban construction and sustainable development, and to meet the needs of future smart city development. Results show that centralized management is very important for the construction of smart city. The government plays a major role in the construction of smart city, which will be conducive to the development of new technologies and the effective use of smart city construction resources.

A compartmental epidemiological model with seven groups is introduced herein, to account for the dissemination of diseases similar to the Coronavirus disease 2019 (COVID-19). In its simplified version, the model contains ten parameters, four of which relate to characteristics of the virus, whereas another four are transition probabilities between the groups; the last two parameters enable the empirical modelling of the effective transmissibility, associated in this study with the cumulative number of fatalities due to the disease within each country. The application of the model to the fatality data (the main input herein) of five countries (to be specific, of those which had suffered most fatalities by April 30, 2020) enabled the extraction of an estimate for the basic reproduction number $R_0$ for the COVID-19 disease: $R_0=4.91(33)$.

4-component relativistic atomic and molecular calculations are typically performed within the no-pair approximation where negative-energy solutions are discarded, hence the symmetry between electronic and positronic solutions is not considered. These states are however needed in QED calculations, where furthermore charge conjugation symmetry becomes an issue. In this work we shall discuss the realization of charge conjugation symmetry of the Dirac equation in a central field within the finite basis approximation. Three schemes for basis set construction are considered: restricted, inverse and dual kinetic balance. We find that charge conjugation symmetry can be realized within the restricted and inverse kinetic balance prescriptions, but only with a special form of basis functions that does not obey the right boundary conditions of the radial wavefunctions. The dual kinetic balance prescription is on the other hand compatible with charge conjugation symmetry without restricting the form of the radial basis functions. However, since charge conjugation relates solutions of opposite value of the quantum number κ, this requires the use of basis sets chosen according to total angular momentum j rather than orbital angular momentum ` . As a special case, we consider the free-particle Dirac equation, where the solutions of opposite sign of energy are related by charge conjugation symmetry. We note that there is additional symmetry in those solutions of the same value of κ come in pairs of opposite energy.