ARTICLE
|
doi:10.20944/preprints202405.0243.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Alzheimer’s disease; amyloid precursor protein; cerebral organoid; disease modeling; drug screening; induced pluripotent stem cells; organoids; tau pathology
Online: 6 May 2024 (07:37:30 CEST)
ARTICLE
|
doi:10.20944/preprints202404.1072.v1
Subject:
Biology And Life Sciences,
Neuroscience And Neurology
Keywords:
Alzheimer’s disease; HSV-1; cholesterol; neuroblastoma cells; methyl-beta-cyclodextrin; infection; neurodegeneration; lysosomal alterations; beta-amyloid; hyperphosphorylated tau
Online: 16 April 2024 (13:59:01 CEST)
ARTICLE
|
doi:10.20944/preprints202305.1347.v1
Subject:
Biology And Life Sciences,
Neuroscience And Neurology
Keywords:
Amyloid ß1-42 peptide; OGT; O-GlcNAcylation; Galectin-1, Galectin-1Serine 8- O-GlcNAcylation; Gal-1S8A; microglia; migration
Online: 18 May 2023 (12:52:22 CEST)
ARTICLE
|
doi:10.20944/preprints202304.1265.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
amyloid bodies; intrinsically disordered protein; liquid-liquid phase separation; membrane-less organelle; nuclear stress bodies; nucleolar biomolecular condensates
Online: 30 April 2023 (05:18:24 CEST)
REVIEW
|
doi:10.20944/preprints202110.0197.v1
Subject:
Medicine And Pharmacology,
Cardiac And Cardiovascular Systems
Keywords:
AGING; Age-related comorbidities; Angiotensin-Converting Enzyme; Amyloid-degrading enzyme; Alzheimer’s disease; Dementia; Hypertension; Life extension; Stress resistance
Online: 13 October 2021 (11:04:43 CEST)
ARTICLE
|
doi:10.20944/preprints202404.0650.v1
Subject:
Public Health And Healthcare,
Public Health And Health Services
Keywords:
steroids; disgust; pregnancy; behavioral immune system; testosterone; estrogens; androstenediol; DHEA; 7α/β-hydroxy-androgens; cortisol
Online: 9 April 2024 (13:01:16 CEST)
ARTICLE
|
doi:10.20944/preprints202402.1309.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
Orthohepadnavirus, X protein, domestic cat hepadnavirus (DCH), hepatitis B virus (HBV), interferon-β signaling pathway
Online: 22 February 2024 (13:25:35 CET)
ARTICLE
|
doi:10.20944/preprints202309.1504.v2
Subject:
Biology And Life Sciences,
Life Sciences
Keywords:
dual release, daptomycin, BMP-2, β-TCP scaffold, ADA-gelatin gel, bone infection, bone regeneration
Online: 24 November 2023 (08:41:16 CET)
ARTICLE
|
doi:10.20944/preprints202309.1790.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
TAp73; PDAC; RAC1b; Biglycan; SMAD3; SMAD4; transforming growth factor-β; epithelial-mesenchymal transition; cell migration
Online: 26 September 2023 (11:48:58 CEST)
ARTICLE
|
doi:10.20944/preprints202309.1695.v1
Subject:
Biology And Life Sciences,
Insect Science
Keywords:
yellow mealworm, edible insects, by-products, rearing substrates, fatty acid, nutraceutical, antioxidant, lycopene, β-Carotene
Online: 26 September 2023 (04:33:31 CEST)
ARTICLE
|
doi:10.20944/preprints202305.0978.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
malignant mesothelioma; metabolism; mitochondria; long-chain specific acyl-CoA dehydrogenase; fatty acid β-oxidation, biomarker
Online: 15 May 2023 (05:27:55 CEST)
ARTICLE
|
doi:10.20944/preprints202303.0539.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
Antibiotic resistance; metallo-β-lactamases; metal-dependent enzymes; broad-spectrum inhibitors; inhibition assays; enzyme kinetics
Online: 31 March 2023 (03:35:02 CEST)
ARTICLE
|
doi:10.20944/preprints202104.0456.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
ethidium; tetraphenylphosphonium; multidrug resistance; outer membrane permeability; efflux inhibitor; phenylalanyl-arginyl-β-naphtylamide, Polymyxin B
Online: 18 April 2021 (10:14:56 CEST)
ARTICLE
|
doi:10.20944/preprints201901.0097.v1
Subject:
Chemistry And Materials Science,
Theoretical Chemistry
Keywords:
2-Hydroxypropyl-β-cyclodextrin (HPβCD); Replica exchange molecular dynamics (REMD); Conformational change; Cavity self-closure
Online: 10 January 2019 (11:43:44 CET)
REVIEW
|
doi:10.20944/preprints202010.0578.v1
Subject:
Biology And Life Sciences,
Anatomy And Physiology
Keywords:
Type 1 diabetes; insulin therapy; C-peptide; islet transplantation, mesenchymal stem cells; induced pluripotent stem cells; pancreatic β cell; gene therapy; β-cell regeneration and reprogramming, type 1 diabetes precision medicine, diabetes personalized care.
Online: 28 October 2020 (10:02:34 CET)
REVIEW
|
doi:10.20944/preprints202306.0051.v1
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
green synthesis; MOFs; amyloid proteins; prionase; mycotoxins; growth inhibition; quorum sensing; quorum quenching; lactamases; biofilms; chitinases; lactonases; His6-OPH
Online: 1 June 2023 (07:31:58 CEST)
REVIEW
|
doi:10.20944/preprints202205.0166.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Antimicrobial Peptides (AMPs); Alzheimer’s Disease (AD); infectious hypothesis; beta-amyloid (Ab); lactoferrin; defensins; cystatins; thymosin β4; histatin 1; statherin
Online: 12 May 2022 (09:40:33 CEST)
ARTICLE
|
doi:10.20944/preprints202104.0270.v1
Subject:
Chemistry And Materials Science,
Analytical Chemistry
Keywords:
Systemic amyloidosis; amyloid fibrils; amyloidogenesis inhibitors; antibody light chains; light chain stabilizers; doxycycline; EGCG; thioflavin T; filter trap; PAINS
Online: 9 April 2021 (15:07:24 CEST)
REVIEW
|
doi:10.20944/preprints202101.0625.v1
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
Alzheimer’s disease; dementia, beta-amyloid; germ theory; drug development; clinical trials; herpes; spirochetes; Chlamydia pneumoniae; Porphyromonas gingivalis; toxoplasma; mycobacteria
Online: 29 January 2021 (13:57:18 CET)
ARTICLE
|
doi:10.20944/preprints202406.0719.v1
Subject:
Medicine And Pharmacology,
Epidemiology And Infectious Diseases
Keywords:
Blood stream infections; carbapenem-resistant gram-negative bacilli,; Klebsiella pneumoniae carbapenemase; New-Delhi metallo-β-lactamase
Online: 11 June 2024 (15:32:58 CEST)
ARTICLE
|
doi:10.20944/preprints202308.0801.v1
Subject:
Biology And Life Sciences,
Food Science And Technology
Keywords:
lipid oxidation; protein oxidation; β-carotene; α-tocopherol; fatty acid; heme iron; beef meat; pasture; concentrate
Online: 10 August 2023 (04:18:19 CEST)
ARTICLE
|
doi:10.20944/preprints201905.0171.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Trypanosoma cruzi; TGF-β; heart fibrosis; extracellular matrix; signaling pathways; SMAD2; p-38 MAPK; c-Jun
Online: 14 May 2019 (12:28:59 CEST)
REVIEW
|
doi:10.20944/preprints201810.0385.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
Parkinson’s disease; cell death; dopaminergic neurons; Wnt/β-catenin signaling; glia-neuron crosstalk; neurodegeneration; neuroprotection; neurorepair
Online: 17 October 2018 (12:28:35 CEST)
HYPOTHESIS
|
doi:10.20944/preprints202109.0437.v2
Subject:
Biology And Life Sciences,
Aging
Keywords:
Alzheimer's; Cellular senescence; Neurodegeneration; Microglia; Astrocytes; Oligodendrocyte Progenitor Cells; TREM2; Braak staging; Oxidative stress; Phapoptosis; Amyloid-beta; Tau; Neuritic plaques
Online: 7 March 2022 (14:22:25 CET)
ARTICLE
|
doi:10.20944/preprints202404.0469.v1
Subject:
Biology And Life Sciences,
Biophysics
Keywords:
Alzheimer’ s disease; amyloid β peptide; human serum albumin; low-molecular-weight ligand; protein-ligand interaction; surface plasmon resonance spectroscopy
Online: 7 April 2024 (10:18:10 CEST)
REVIEW
|
doi:10.20944/preprints202110.0222.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
Alzheimer's disease; amyloid-beta; animal model; astrocyte; blood-brain barrier; imaging; metabolism; microglia; neuroinflammation, neurotransmitter receptors; positron emission tomography; synaptic density
Online: 15 October 2021 (11:02:57 CEST)
ARTICLE
|
doi:10.20944/preprints202404.1628.v1
Subject:
Biology And Life Sciences,
Life Sciences
Keywords:
α-synuclein; β-synuclein; γ-synuclein; intrinsically disordered protein; liquid-liquid phase separation; Parkinson’s disease; protein-protein interactions
Online: 24 April 2024 (15:35:56 CEST)
ARTICLE
|
doi:10.20944/preprints202401.0241.v1
Subject:
Medicine And Pharmacology,
Dietetics And Nutrition
Keywords:
Puerariae Lobatae Radix; High salt diet; Chronic kidney disease; Wnt / β-catenin pathway; Gut microbiota; Fecal microbiota transplantation
Online: 3 January 2024 (10:35:50 CET)
ARTICLE
|
doi:10.20944/preprints201907.0140.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
PlGF; PGF; blood-retinal barrier; RNA Seq; HREC; gene ontology; fastQC; Trimmomatic; KEGG; pentose phosphate pathway; TGF-β
Online: 10 July 2019 (07:48:20 CEST)
ARTICLE
|
doi:10.20944/preprints202405.1797.v1
Subject:
Biology And Life Sciences,
Aging
Keywords:
Carotenoids; phytoene; bioactive compounds; microalgae; ageing; oxidative stress; antioxidant; anti-ageing; Alzheimer; amyloid-β 42 proteotoxicity; Chlorella sorokiniana; Dunaliella bardawil; C. elegan
Online: 28 May 2024 (09:30:41 CEST)
ARTICLE
|
doi:10.20944/preprints202312.2306.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
Ethylene-di-amine modified β-CD; Multicomponent reaction; 3,4-dihydropyrimidin-2(1H)-ones DHPM derivatives; Solvent-free conditions; Reusability
Online: 29 December 2023 (14:34:42 CET)
ARTICLE
|
doi:10.20944/preprints202312.1664.v1
Subject:
Medicine And Pharmacology,
Other
Keywords:
leishmaniasis; selenide; 2,5-dihydrooxazole; indole; chromone; coumarin; β-naphthol; 1,3,4-oxadiazole; imidazo[1,2-a]pyridine; imidazo[2,1-b]thiazole
Online: 21 December 2023 (16:01:01 CET)
ARTICLE
|
doi:10.20944/preprints202012.0398.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
1α,25-dihydroxyvitaminD3; photoprotection; DNA damage; cyclobutane pyrimidine dimers; edema; photoimmune suppression; female vs male mice; ER-β knockout
Online: 16 December 2020 (08:49:22 CET)
ARTICLE
|
doi:10.20944/preprints202004.0390.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
SARS-CoV-2; COVID-19; SARS-CoV; ACE2; spike protein; phosphorylation; O-β-GlcNAcylation; molecular docking; chloroquine; 2-hydroxybenzohydrazine
Online: 22 April 2020 (06:01:00 CEST)
ARTICLE
|
doi:10.20944/preprints201903.0166.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
Structure-based design; glycogen phosphorylase inhibitor; glycogen metabolism; type 2 diabetes; X-ray crystallography; N-acyl-β-D-glucopyranosylamine
Online: 15 March 2019 (14:06:06 CET)
ARTICLE
|
doi:10.20944/preprints201812.0157.v1
Subject:
Biology And Life Sciences,
Cell And Developmental Biology
Keywords:
blood cells; differentiation; myeloid leukemia; monocytes; lymphocytes; transcription factors; all-trans-retinoic acid; interleukin 2; transforming growth factor β
Online: 12 December 2018 (15:51:17 CET)
ARTICLE
|
doi:10.20944/preprints202311.1252.v1
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
Synechocystis PCC 6803; Synechococcus PCC 7002; farnesene; limonene; RubisCO; phosphoribulokinase; carboxysome; geranylgeranyl pyrophosphate synthase; β-carotene hydroxylase; γ-carotene hydroxylase
Online: 20 November 2023 (16:06:55 CET)
REVIEW
|
doi:10.20944/preprints202204.0189.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
astrocytes; reactive astrogliosis; TGF-β; traumatic brain injury; stroke; aging; Alzheimer’s disease; Parkinson’s disease; amyotrophic lateral sclerosis; multiple sclerosis; epilepsy
Online: 20 April 2022 (09:06:47 CEST)
ARTICLE
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Human induced pluripotent stem cells (hiPSCs); monoclonal antibodies; R-10G; R-17F; keratan sulfate; podocalyxin; keratanase II; endo-β-galactosidase
Online: 9 March 2021 (12:13:56 CET)
ARTICLE
|
doi:10.20944/preprints202102.0296.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
End-Stage Renal Disease, Chronic Kidney Disease, Wnt-Pathway, R-Spondin 1, β-Catenin, Dickkopf-Related Protein 1, and Sclerostin.
Online: 12 February 2021 (10:08:22 CET)
ARTICLE
|
doi:10.20944/preprints202208.0030.v1
Subject:
Medicine And Pharmacology,
Cardiac And Cardiovascular Systems
Keywords:
ascending aorta aneurysm; bicuspid aorta valve; tricuspid aorta valve; ERG transcriptional factor pathway; TGF-β-SMAD, Notch, and NO pathways modulation.
Online: 2 August 2022 (03:43:22 CEST)
COMMUNICATION
|
doi:10.20944/preprints202206.0374.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
antimicrobial resistance; CTX-M-1; Enterobactericeae,; Escherichia coli; extended-spectrum β-lactamase; food safety; IncI1; next-generation sequencing; One Health; virulence
Online: 28 June 2022 (04:18:22 CEST)
ARTICLE
Subject:
Chemistry And Materials Science,
Nanotechnology
Keywords:
Sepiapterin; triacetyl-β-cyclodextrin (TAβCD); hydrophilic drug/cyclodextrin complexes; spray-drying; methoxy-poly(ethylene-glycol)-poly(epsilon-caprolactone) (mPEG-PCL) nanoparticles
Online: 24 May 2019 (11:42:42 CEST)
ARTICLE
|
doi:10.20944/preprints202312.1924.v1
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
BV-2 microglia; cathepsin B; CA-074Me; human β-defensin 3; interleukin-1β; lipopolysaccharide; nuclear factor-κB; outer membrane vesicles; Prophyromonas gingivalis
Online: 26 December 2023 (06:27:43 CET)
REVIEW
|
doi:10.20944/preprints202307.1284.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Cancer; tumourigenesis; drug resistance; signalling pathways; Wnt/β-catenin pathway; JAK/STAT pathway; PI3K/Akt/mTOR pathway; RAS/RAF/MAPK/ERK signalling
Online: 19 July 2023 (09:14:02 CEST)
ARTICLE
|
doi:10.20944/preprints201808.0166.v1
Subject:
Chemistry And Materials Science,
Physical Chemistry
Keywords:
Ferrocenium conformers, electron structure of organometallic complexes, excess orbital energy spectrum (EOES), α- and β-electrons of Fc+, energy decomposition analysis (EDA).
Online: 8 August 2018 (11:16:59 CEST)
ARTICLE
|
doi:10.20944/preprints202407.0723.v1
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
Maresin-like; Alzheimer's Disease; neuroinflammation; neuropathogenesis; amyloid-β (Aβ ); cholinergic neuron; cleaved-caspase-3; M1 or M2 microglia; A1 or A2 astrocytes; N1 or N2 neutrophil
Online: 9 July 2024 (12:24:29 CEST)
ARTICLE
|
doi:10.20944/preprints202105.0461.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
ACE2; Ang II; AT1R; AT2R; angiotensin (1-7); β-arrestin; CFTR; COVID-19; ENaC; GPCR; MERS-CoV; SARS-CoV2; SARS-CoV; G-protein
Online: 20 May 2021 (09:28:37 CEST)
ARTICLE
|
doi:10.20944/preprints202405.1741.v1
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
Alzheimer’ s disease; vascular complications; monoclonal antibody therapy; Aducanumab; Lecanemab; epoxide of polyunsaturated fatty acid; soluble epoxide hydrolase inhibitor EC5026; EP4 inhibitor; monocyte/macrophage; amyloid-beta degradation
Online: 27 May 2024 (13:00:54 CEST)
ARTICLE
|
doi:10.20944/preprints201907.0326.v2
Subject:
Physical Sciences,
Particle And Field Physics
Keywords:
zero‐point energy; quantized spacetime; static electromagnetic field; gravity field; weak interaction; strong interaction; masses of W and Z; β collapse; quantized Einstein gravity equation
Online: 9 November 2023 (13:40:49 CET)
ARTICLE
|
doi:10.20944/preprints202306.0548.v1
Subject:
Medicine And Pharmacology,
Gastroenterology And Hepatology
Keywords:
non-alcoholic steatohepatitis; hepatocellular carcinoma; farnesyltransferase inhibitor; hypoxia-inducible factor-1α; anti-inflammatory response; nuclear factor-κB; transforming growth factor-β; Warburg effect; reactive oxygen species; interleukin-6
Online: 7 June 2023 (12:05:28 CEST)
ARTICLE
|
doi:10.20944/preprints202210.0311.v1
Subject:
Medicine And Pharmacology,
Dentistry And Oral Surgery
Keywords:
Animal study; beagle dog; β-tricalcium phosphate (TCP); immunohistochemistry; micro computed tomography (CT); periodontal tissue engineering; periostin; recombinant human collagen peptide (RCP); scaffold material; 3-wall intrabony defect
Online: 20 October 2022 (12:24:49 CEST)
REVIEW
|
doi:10.20944/preprints201903.0108.v1
Subject:
Biology And Life Sciences,
Cell And Developmental Biology
Keywords:
Nucleolar sequestration, nucleolus, physiological amyloids, ribosomal intergenic spacer, rIGSRNA, liquid-liquid phase separation, liquid-to-solid phase transition, complex coacervation, biomolecular condensates, beta-amyloid, MDM2, VHL, Cdc14, low complexity RNA, acidosis, heat shock
Online: 8 March 2019 (15:12:29 CET)
ARTICLE
|
doi:10.20944/preprints202310.1959.v2
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
Phlomoides rotata (Benth. ex Hook. f.) Mathiesen (Lamiophlomis rotata (Benth.) Kudô); essential oils; chemical markers; fatty acids; palmitic acid; C13-norisoprenoids; trans-β-damascenone; anti-oxidant activities; pro-oxidant activities
Online: 31 October 2023 (09:01:09 CET)