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Preprint ARTICLE | doi:10.20944/preprints202007.0086.v1

Physicochemical Changes Occurring during Long-Time Fermentation of the Indigenous Alcoholic Sorghum-Based Beverages Brewed in the Northern Cameroon

James Ronald Bayoï, Francois-Xavier Etoa

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Cameroon; sudano-sahelian zone; sorghum; long-time fermentation; turbid beers; physicochemical changes; clustering

Online: 5 July 2020 (15:38:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0134.v1

Time-Restricted Feeding Improves Body Weight Gain, Lipid Profile, and Atherogenic Indices in Cafeteria Diet-fed Rats: Role of Browning Inguinal White Adipose Tissue

Samira Aouichat, Souhila Bouguerra-Aouichat, Ahmad Agil

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: time-restricted feeding; cafeteria diet; obesity; lipid profiles; atherogenic indices; browning adipose tissue

Online: 11 June 2020 (11:56:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0313.v1

Optimizing Vehicle Routing for Simultaneous Pick-up and Delivery considering the Reusable Transporting Containers: Case of Convenient Stores

Intaek Gong, Kyungho Lee, Jaewon Kim, Yunhong Min, Kwang Sup Shin

Subject: Business, Economics And Management, Business And Management Keywords: Vehicle Routing Problem; Delivery and Pickup; Time Windows; Left-over Cost; Reusable Container

Online: 19 May 2020 (09:27:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0175.v1

Covid-19 Predictions Using a Gauss Model, Based on Data from April 2

Janik Schüttler, Reinhard Schlickeiser, Frank Schlickeiser, Martin Kröger

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: coronavirus; statistical analysis; extrapolation; parameter estimation; pandemic spreading; virus; forecast; time evolution; dynamics

Online: 11 April 2020 (01:25:26 CEST)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202003.0038.v1

Automated Inundation History Mapping over Large Areas using Landsat and Google Earth Engine

Victoria L Inman, Mitchell B Lyons

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Okavango Delta; inundation maps; inundation extent; Landsat; Google Earth Engine; automated time series

Online: 3 March 2020 (11:25:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202001.0273.v1

The Theories of Relativity and Bergson's Philosophy of Duration and Simultaneity During and After Einstein's 1922 Visit to Paris

CS Unnikrishnan

Subject: Physical Sciences, Theoretical Physics Keywords: Einstein's relativity; Bergson's philosophy; Time; Simultaneity; Twin paradox; Universe; Cosmic gravity; Cosmic Relativity

Online: 23 January 2020 (16:50:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202001.0205.v1

Variation of the Performance of Machine-Learning Based Image Classifier in Automated Detection of Itch-Induced Scratch

Chuan Liu, Sheng-Xiang Yan, Xiao-Bo Wu, Zhi-Jun Zhang, Wei Li

Subject: Social Sciences, Behavior Sciences Keywords: itch; scratch; automated real-time detection; machine-learning based image classifier; image sharpness

Online: 19 January 2020 (03:13:48 CET)

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Preprint REVIEW | doi:10.20944/preprints202001.0094.v1

The Effect of Plastocrete® RT6 Plus and Coca-Cola Admixtures on The Concrete Setting Time and Strength

Tamrin Rahman, Mardewi Djamal, Juli Nurdiana, Amirul Mirza Ghulam

Subject: Engineering, Civil Engineering Keywords: concrete setting time; Coca-cola; silica fume; fly ash; Plastocrete® RT6 Plus

Online: 10 January 2020 (06:55:02 CET)

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During the casting in a warmer tropical temperature, a setting time delay is required to maintain the workability of the concrete, commonly achieved by the addition of admixtures i.e. silica fume (SF), fly ash (FA), and Plastrocrete®. However, high sugar content Coca-Cola in niche conditions is proposed as an ingredient for delaying concrete setting time in combination with conventional admixtures. This research aims to compare the setting time of admixtures from Coca-Cola and Plastocrete® RT6 plus in concrete mixing with control data of concrete mixed with SF or FA. The second aim is to measure the compression strengths between combinations of Coca-Cola and Plastocrete® RT6 plus. Concretes were produced with admixtures of SF, FA, Plastocrete® RT6plus, or Coca-Cola. The concrete used to control was f'c20 and f'c 25, while other concrete mixes were produced with the addition of Coca-Cola at 0.15% from the weight of cement at variation of moisture treatments. The first method to produce concrete (f'c20+Plas0.23%+Cola0.15% and f'c25+Plas0.23%+Cola0.15%) did not employ water reduction. The second concrete productions (f'c25+Plas0.46%+Cola0.15% and f'c25+Plas0.46%+Cola0.15%) reduced the addition of water at 8.8% (v/w). The first concrete production method had a setting time 44% longer than control. The reduced water concrete in the second productions had a setting time 34% longer than control. Meanwhile, the Plastocrete® RT6 Plus admixture with the reduced water delayed the concrete setting time by 26% longer than control. The delayed setting time of Plastocrete® RT6 Plus admixture with reduction of water was shorter than in the treatment with Coca-Cola. The combination of the addition of Coca-Cola with Plastocrete® RT6 plus by reducing the amount of adding Coca-Cola to 0.10% with Plastocrete® RT6 plus can delay concrete setting time by 51% longer than normal concrete and increase concrete compressive strength by 13% higher than normal concrete. Mixing Coca-Cola with Plastocrete® RT6 plus not only provided an optimal delay effect on setting time but also significantly increase the compressive strength that was desired during the casting in warm tropical weather applied in building construction of Mulawarman University, Samarinda, Indonesia.

Preprint ARTICLE | doi:10.20944/preprints201912.0370.v1

Lorentz Symmetry Group, Retardation, and Galactic Rotation Curves

Asher Yahalom

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: spacetime symmetry; Relativity of space-time; Lorentz Symmetry Group; retardation; Galactic Rotation Curves

Online: 29 December 2019 (04:57:08 CET)

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Working Paper ARTICLE

Compressed Orthogonal Coded Multiplexing Wide-band Millimeter Wave Imaging - A Numerical Study

Hao Tu, Xiangxin Meng, Taorong Liu, Hui Feng, Shuai Wu

Subject: Engineering, Electrical And Electronic Engineering Keywords: millimeter wave imaging; orthogonal coded multiplexing; compressed sensing; real-time imaging; dynamic range

Online: 10 November 2019 (09:40:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints201909.0151.v1

Fragility Assessment of Container Crane under Seismic Excitation Considering Uplift and Derailment Behavior

Quang Huy Tran, Jungwon Huh, Nhu Son Doan, Van Ha Mac, Jin-Hee Ahn

Subject: Engineering, Civil Engineering Keywords: STS container crane; uplift and derailment; time history analysis; pushover analysis; fragility assessment

Online: 15 September 2019 (06:26:29 CEST)

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Working Paper ARTICLE

Possible Lattice-Like Medium for Electron Pairing in La₂CuO₄

Tiege Zhou

Subject: Physical Sciences, Condensed Matter Physics Keywords: high temperature copper-oxide superconductors; time-dependent density functional theory; electron-pairing medium

Online: 10 July 2019 (10:29:23 CEST)

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Working Paper ARTICLE

On a Duality between Time and Space Cones

Waleed Al-qallaf, Kyriakos Papadopoulos

Subject: Computer Science And Mathematics, Geometry And Topology Keywords: causality; chronology; chorology; Minkowski space; time cone; space cone; weak interval topology; duality

Online: 24 May 2019 (08:22:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0522.v2

Contactless In Situ Electrical Characterization Method of Printed Electronic Devices with Terahertz Spectroscopy

Mariia Zhuldybina, Xavier Ropagnol, Charles Trudeau, Martin Bolduc, Ricardo J. Zednik, François Blanchard

Subject: Physical Sciences, Optics And Photonics Keywords: printed electronics; inkjet printing; terahertz time-domain spectroscopy; vortex phase plate; vortex beam

Online: 28 January 2019 (10:39:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0260.v2

Real-Time Inferential Analytics Based on Online Databases of Trends: A Breakthrough within the Discipline of Digital Epidemiology in Dentistry and Dental Anatomy

Ahmed Al-Imam, Usama Khalid, Nawfal Al-Hadithi, Dawoude Kaouche

Subject: Computer Science And Mathematics, Information Systems Keywords: evidence-based dentistry; public health dentistry; google trends; real-time analytics; predictive analytics

Online: 16 November 2018 (10:34:04 CET)

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BACKGROUND Epidemiological sciences have been evolving at an exponential rate paralleled only by the comparable growth within the discipline of data science. Digital epidemiological studies are playing a vital role in medical science analytics for the past few decades. To date, there are no published attempts at deploying the use of real-time analytics in connection with the disciplines of Dentistry or Medicine. AIMS AND OBJECTIVES We deployed a real-time statistical analysis in connection with topics in Dental Anatomy and Dental Pathology represented by the maxillary sinus, posterior maxillary teeth, related oral pathology. The purpose is to infer the digital epidemiology based on a continuous stream of raw data retrieved from Google Trends database. MATERIALS AND METHODS Statistical analysis was carried out via Microsoft Excel 2016 and SPSS version 24. Google Trends database was used to retrieve data for digital epidemiology. Real-time analytics and the statistical inference were based on encoding a programming script using Python high-level programming language. A systematic review of the literature was carried out via PubMed-NCBI, the Cochrane Library, and Elsevier databases. RESULTS The comprehensive review of databases of the literature, based on specific keywords search, yielded 491813 published studies. These were distributed as 488884 (PubMed-NCBI), 1611 (the Cochrane Library), and 1318 (Elsevier). However, there was no single study attempting real-time analytics. Nevertheless, we succeeded in achieving an automated real-time stream of data accompanied by a statistical inference based on data extrapolated from Google Trends. CONCLUSION Real-time analytics are of considerable impact when implemented in biological and life sciences as they will tremendously reduce the required resources for research. Predictive analytics, based on artificial neural networks and machine learning algorithms, can be the next step to be deployed in continuation of the real-time systems to prognosticate changes in the temporal trends and the digital epidemiology of phenomena of interest.

Preprint ARTICLE | doi:10.20944/preprints201809.0522.v1

Time Series Analysis of MODIS-Derived NDVI for the Hluhluwe-iMfolozi Park, South Africa: Impact of Recent Intense Drought

Nkanyiso Mbatha, Sifiso Xulu

Subject: Environmental And Earth Sciences, Environmental Science Keywords: drought; NDVI; ENSO; wavelet; time series analysis; Hluhluwe-iMfolozi Park; Google Earth Engine

Online: 26 September 2018 (15:53:40 CEST)

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The variability of meteorological parameters such as temperature and precipitation, and climatic conditions such as intense droughts, are known to impact vegetation health over southern Africa. Thus, understanding large-scale ocean–atmospheric phenomena like the El Niño/Southern Oscillation (ENSO) and Indian Ocean Dipole/Dipole Mode Index (DMI) is important as these factors drive the variability of temperature and precipitation. In this study, 16 years (2002–2017) of Moderate Resolution Imaging Spectroradiometer (MODIS) Terra/Aqua 16-day normalized difference vegetation index (NDVI), extracted and processed using JavaScript code editor in the Google Earth Engine (GEE) platform in order to analyze the response pattern of the oldest proclaimed nature reserve in Africa, the Hluhluwe-iMfolozi Park (HiP), during the study period. The MODIS-enhanced vegetation index and burned area index were also analyzed for this period. The area-averaged Modern Retrospective Analysis for Research Application (MERRA) model maximum temperature and precipitation were also extracted using the JavaScript code editor in the GEE platform. This procedure demonstrated a strong reversal of both the NDVI and Enhanced Vegetation Index (EVI), leading to signs of a sudden increase of burned areas (strong BAI) during the strongest El Niño period. Both the Theilsen method and the Mann–Kendall test showed no significant greening or browning trends over the whole time series, although the annual Mann–Kendall test, in 2003 and 2014–2015, indicated significant browning trends due to the most recent strongest El Niño. Moreover, a multi-linear regression model seems to indicate a significant influence of both ENSO activity and precipitation. Our results indicate that the recent 2014–2016 drought altered the vegetation condition in the HiP. We conclude that it is vital to exploit freely available GEE resources to develop drought monitoring vegetation systems, and to integrate climate information for analyzing its influence on protected areas, especially in data-poor counties.

Preprint ARTICLE | doi:10.20944/preprints201808.0389.v2

Measurement of Opportunity Cost of Travel Time for Predicting Future Residential Mobility Based on the Smart Card Data of Public Transportation

Takashi Nicholas Maeda, Junichiro Mori, Masanao Ochi, Tetsuo Sakimoto, Ichiro Sakata

Subject: Social Sciences, Geography, Planning And Development Keywords: human mobility; residential mobility; smart card; public transportation; opportunity cost of travel time

Online: 26 September 2018 (05:46:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0374.v1

Ground-Penetrating Radar to explore spatial variations of thaw thickness and internal structure in the active layer of Tibetan Plateau based on Reverse time Migration Method

Xinglin Lu, Ao Song, Jiwen Xiao, Zhenning Ma, Rongyi Qian, Qingbai Wu

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Qinghai Tibet Plateau; permafrost; active layer thickness; ground penetrating radar; reverse time migration

Online: 21 August 2018 (09:13:59 CEST)

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The active layer thickness (ALT) is affected by local soil material and surface vegetation coverage in Tibetan plateau permafrost region. The human activities and engineering construction along the Qinghai-Tibet Highway (QTH) destroyed the surface vegetation coverage, which have seriously influenced the ALT and heat exchange balance. Meanwhile, the changes of the detailed internal structure in the active layer will affect the stability of engineering infrastructure. Ground-penetrating radar (GPR) was used to detect the ALT in the permafrost region. However, researches on the detailed structure of the active layer and spatial variation information of ALT are rare, the main reason given for this is that the lack of advanced imaging techniques to enhance the GPR images. In this paper, the researchers focus on solving this problem by applying the reverse time migration (RTM) method to GPR field data acquired in the Beiluhe region. Analyses of the results led to conclusions as follows: a) The RTM algorithm is proved to be accurate for imaging the characteristics of the active layer through the dielectric constant model obtained by common midpoint and GPR data velocity analysis. b) The result of RTM profiles show the loose structure and graben-like fine internal structure. Combining with drill data and soil materials information, the researchers deduce the graben-like structure might be coarse gravel layer, which may be related to subgrade settlements in some local area. c) The 2D contour maps not only show the spatial variation feature of ALT at two sides of the highway, but also can compensate the defect of the research for single 2D survey line. The ALT is about 0.6~0.8 m in most areas, and about 0.8~0.9 m near the highway at west side of the QTH on the 2D contour maps. From the RTM interpretation profile, the closer to the plash, the deeper thawed active layer. The detailed internal structure of the active layer and 2D contour maps of ALT have great significance for the study of fine internal structure and the characteristic of ALT spatial variation in the Tibetan plateau under the background of climatic change.

Preprint ARTICLE | doi:10.20944/preprints201807.0081.v1

SiO₂-SnO₂:Er³⁺ Glass-Ceramic Monoliths

Lam Thi Ngoc Tran, Damiano Massella, Lidia Zur, Alessandro Chiasera, Stefano Varas, Cristina Armellini, Giancarlo C. Righini, Anna Lukowiak, Daniele Zonta, Maurizio Ferrari

Subject: Physical Sciences, Applied Physics Keywords: transparent glass-ceramics; luminescence sensitizer; SiO2-SnO2; erbium; Sol-gel; time- resolved spectroscopy

Online: 5 July 2018 (07:36:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0171.v1

Specific and Complete Local Integration of Patterns in Bayesian Networks

Martin Biehl, Takashi Ikegami, Daniel Polani

Subject: Computer Science And Mathematics, Mathematics Keywords: identity over time; Bayesian networks; multi-information; entity; persistence; integration; emergence; naturalising agency

Online: 21 March 2017 (16:23:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints201609.0032.v1

Exploiting Symmetric Energy Harvesting Protocol in Wireless Sensor Networks with Outdated Channel State Information: Protocol Design and Performance Analysis

Dinh-Thuan Do, Hoang-Sy Nguyen, Miroslav Voznak

Subject: Engineering, Electrical And Electronic Engineering Keywords: channel state information; energy harvesting; amplify-and-forward; time power switching relaying; throughput

Online: 8 September 2016 (11:59:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0083.v1

The Joint Use of Multiple Satellite SAR Data and Geotechnical Models for the Study of the Shanghai Ocean-Reclaimed Lands

Antonio Pepe, Manuela Bonano, Qing Zhao, Tianliang Yang, Hanmei Wang

Subject: Environmental And Earth Sciences, Environmental Science Keywords: deformation; interferometry; geotechnical models; non‐linear problem; synthetic aperture radar (SAR); time‐series

Online: 8 August 2016 (14:50:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1244.v1

The Influence of In-Plane Constraints on Fatigue Crack Growth Rate

Jaroslaw Galkiewicz, Urszula Janus-Galkiewicz, Sebastian Lipiec

Subject: Mechanical Engineering, Engineering Keywords: fatigue crack growth; Paris’ law; in-plane constraints; brittle fracture; Williams’ solution

Online: 18 September 2024 (05:17:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.0642.v1

Conformational Mobility of Voltage-Gated Ion Channels

Ekaterina Kravchuk, Elizaveta Trifonova, Olga S. Sokolova

Subject: Biology And Life Sciences, Biophysics Keywords: voltage-gated ion channels; conformation; membrane mimetics; cryoelectron microscopy; in situ analysis; coordinated motion

Online: 9 September 2024 (09:20:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0461.v1

Examining Physicians’ Approaches to Treating Relatives in Primary Health Care Centers: Insights from a Qualitative Study

Manal R Alhamdan, Nouf M Aloudah, Saleh Alrajhi

Subject: Public Health And Healthcare, Primary Health Care Keywords: Ethics; Morality; Conduct; Qualitative; In-depth interviews; Treating family members; Theory underpinning; Decision making

Online: 5 September 2024 (12:48:44 CEST)

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Introduction: Family medicine physicians take care of a diverse population of patients with a variety of acute and chronic diseases. These patients include family, friends, and acquaintances who may ask for direct medical care or help in accessing healthcare products and services, within or outside of officially approved procedures. This is ethically challenging due to an ambiguous medical code of ethics, but it is commonly accepted as normal behavior by society. Clinical ethics and the moral code of conduct together define how physicians should deal with such requests. However, Saudi physicians, like most individuals in Saudi society, are governed by the societal code of conduct when dealing with requests and favors from others. The aim of this study is to explore family medicine physicians’ perspectives regarding the benefits, difficulties, and ethics of responding to medical care requests and/or favors from family, relatives, friends, and acquaintances and to make recommendations. Methods: The study sample consisted of junior and senior family medicine physicians working in primary healthcare centers affiliated with the Ministry of Health in Saudi Arabia. In-depth semi-structured interviews were conducted to collect data. Using Social Exchange Theory, this qualitative study explores how family medicine physicians perceive and handle requests for medical favors from family members and others. Results: Semi-structured interviews were conducted with 19 family medicine physicians with clinical experience ranging from 3 to 20 years. Data analysis identified three themes: perceived benefits and costs of cultural and social connectedness, shortcomings in patient management and healthcare systems, and recommendations to address challenges between physicians and patients who are relatives. Discussion and conclusion: The study shows that treating others outside of normal access to healthcare services presents several ethical, moral, and professional challenges. Therefore, policy adaptation requires understanding this intricate dilemma and improving laws, system regulations, and guidelines for physicians and community members to improve access to care, reduce system abuse, empower providers, and enhance community awareness and compliance.

Preprint ARTICLE | doi:10.20944/preprints202409.0331.v1

Did the COVID-19 Crisis Reframe Public Awareness of Environmental Topics as Humanity’s Existential Risks? A Case from the UK

Andreas Y Troumbis

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Existential risks; COVID-19; Difference-in-Differences; environmental topics; biodiversity; climate change; sustainability; UK

Online: 5 September 2024 (04:53:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.2073.v1

Development and Applications of Somatic Embryogenesis in Grapevine (Vitis spp.)

Angela Carra, Akila Wijerathna-Yapa, Ranjith Pathirana, Francesco Carimi

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Germplasm; Mutagenesis; in vitro culture; Tissue culture; Micropropagation; Conservation; Somaclonal variation; Transformation; Chimera; Virus

Online: 29 August 2024 (08:49:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0842.v1

Solvent Polarity Effects on Phenolic Fingerprint and Biological Activities, Using Three Different Extractions Formulation for Examining of Mentha aquatica Leaf Extracts: An In Vitro and In‐Silico Investigation

Meryem TOURABI, AMIRA Metouekel, Mohammed Jeddi, Mohamed Chebaibi, Nesrine Benkhaira, Kawtar Fikri Benbrahim, Badiaa Lyoussi, Elhoussine Derwich

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Mentha aquatica; HPLC‐DAD analysis; in‐silico approach; solvent polarity; antioxidant activity; antibacterial activity

Online: 10 July 2024 (11:47:35 CEST)

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The main purpose of our research is the evaluation of the efficacity of solvent polarity on phenolic composition, as well as the antibacterial, and antioxidant activities of extract of Moroccan Mentha aquatica L., leaves. To attempt these objectives, the HPLC-DAD was used to identify the biomolecules. The total amount of phenolic and flavonoid content was determined using the Folin-Ciocalteu and aluminum trichloride processes as well as the DPPH, RP, and TAC tests were used to evaluate the antioxidant capabilities. In addition, by employing both in vitro and in silico analysis through the microdilution method, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the extracts were assessed against multidrug-resistant bacteria. Furthermore, the High-Performance Liquid Chromatography (HPLC) analysis indicated that all extracts of M. aquatica were abundant in noteworthy phytochemical compounds, especially gallic acid, vanillic acid, chlorobenzoic acid, quercetin, and kaempferol. Furthermore, the results indicated that the total phenolic content was higher in hydroethanolic extract (62.19 ± 1.19 mg GAE/g DW) in contrast to the acetonic and aqueous extracts (22.22 ± 0.64, and 22.44± 0.57 mg GAE/g DW) respectively. Similarly, the aqueous ethanol extract contained the greatest flavonoid concentration, with values of 29.15± 0.09 mg QE/g DW when compared with the other extracts. The seam extract poses excellent antioxidant power with an IC50 of 0.06 ± 0.00 mg/mL for the DPPH test, and lower RP with EC50 of 80± 0.00 µg/ml when compared with acetonic and aqueous extract (370± 0.00 and 460± 0.01 µg/mL) respectively. Moreover, the hydroethanolic extract has a high level of TAC 75.09± 2.00 mg EAA/g DW, followed by aqueous extract carrying a value of 28.53 ± 1.36 mg EAA/g DW. The antibacterial capacity is ranged between 0.78 ± 0.05 mg/mL and 12.60 ± 0.00 mg/L. The results of the in-silico study demonstrated that quercetin, vanillic acid, and naringenin components contribute to the antioxidant capability. While gallic acid, kaempferol, and quercetin components are attributed to the antibacterial capacity.

Preprint ARTICLE | doi:10.20944/preprints202407.0739.v1

Development and Test of Low-Cost Multi-channel Multi-frequency Lock-In Amplifier for Health and Environment Sensing

Fabio Pollastrone, Luca Fiorani, Ramanand Bisauriya, Ivano Menicucci, Claudio Ciceroni, Roberto Pizzoferrato

Subject: Engineering, Electrical And Electronic Engineering Keywords: lock-in amplifier (LIA); digital signal processing; photoluminescence measurements; laser photoacoustic spectroscopy (LPAS); microcontroller

Online: 9 July 2024 (10:49:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0883.v1

Optical Coherence Tomography in Infectious Keratitis after Femtosecond Keratorefractive Surgery

Antonio Leccisotti, Stefania Valeria Fields, Giuseppe De Bartolo, Christian Crudale, Matteo Posarelli

Subject: Medicine And Pharmacology, Ophthalmology Keywords: optical coherence tomography; laser in situ keratomileusis (LASIK); keratorefractive lenticule extraction (KLEx); infectious keratitis

Online: 13 June 2024 (11:51:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0553.v1

Long-Term Monitoring of Indoor CO Levels in Disproportionately Impacted Communities in the North Denver Metropolitan Area

Sumit Sankhyan, Aniya K Hollo, Dulce Gonzalez-Beltran, Nicholas Clements, Shelly L. Miller

Subject: Environmental And Earth Sciences, Environmental Science Keywords: gas appliance emissions; indoor air quality; electrification in homes; adverse health effects; carbon monoxide

Online: 10 June 2024 (09:58:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0227.v1

Analyzing the Shortcomings in Smart Healthcare for Remote Home Care—A Case Study of the Taiwan Market

Yunqi Yang, Grace.T.R Lin

Subject: Public Health And Healthcare, Health Policy And Services Keywords: Smart Healthcare; Telemedicine; Home Remote Care; AHP (Analytic Hierarchy Process); Expert In-depth Interviews

Online: 5 June 2024 (07:35:07 CEST)

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In Taiwan, remote healthcare was initially limited to telemedicine services, and the systematic development of remote care was relatively delayed. It was not until 2007 that the Department of Health of the Executive Yuan first initiated the 'Remote Care Pilot Program,' followed by the 'Remote Care Service Improvement and Quality Enhancement Plan' in the subsequent year. In 2010, Taiwan officially launched the 'Remote Health Care Services Development Plan' and established a dedicated project office, marking the comprehensive start-up of remote care services. This stage saw significant contributions from artificial intelligence aids and ICT remote transmission technologies, greatly promoting the application of smart healthcare in home care. This study aims to explore the strategic gaps in the application of smart healthcare in home remote care. By analyzing gaps in 'legal regulations,' 'economic factors,' 'user behavior habits,' 'policy and culture,' and 'environment and technology,' this study employs a mixed-methods approach. Particularly, it uses the Analytic Hierarchy Process (AHP) to construct a weighted ranking of these strategic gaps. Through in-depth interviews with doctors and smart healthcare experts and the collection of 16 valid AHP questionnaire samples, which cover both industry and academia with a balanced distribution, the survey results are ensured to be representative and reliable. The findings indicate that 'legal regulations' are considered the most critical strategic gap that needs to be addressed first, followed by 'user behavior habits.' This suggests that when designing smart healthcare applications, greater consideration needs to be given to user acceptance and habits. By systematically analyzing and addressing these strategic gaps, this study not only provides solutions to issues in the application of smart healthcare in home remote care but also offers valuable references for future research and practice, aiming to make home remote care services more comprehensive and efficient.

Preprint ARTICLE | doi:10.20944/preprints202405.2072.v1

Real-Time Quality Inspection through Industry 4.0 Technologies

Junior Anchundia, Francescoly Berrones, Alexandra Verdugo, Mayra Comina

Subject: Engineering, Mechanical Engineering Keywords: Quality 4.0; digital transformation; Industry 4.0; artificial intelligence in quality control; automated inspection systems

Online: 30 May 2024 (15:52:31 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202405.2027.v1

Physical Chemical, Immunological and Biological Characterization of Arapaima 2 gigas Follicle-Stimulating Hormone (ag-FSH) synthesized in HEK293 Cells

Eliana Rosa Lima, Thaís Sevilhano, Thais Caramori, João Ezequiel Oliveira, Miriam Fussae Suzuki, Lucas Simon Torati, Paolo Bartolini, Cibele Nunes Peroni

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Arapaima gigas; follicle-stimulating hormone; in-vitro bioassay; immature testis; 11-keto-29 testosterone.

Online: 30 May 2024 (13:17:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1375.v1

Demographic Differences and Spatiotemporal Analysis of Visual Perception in Commercialized Historic Streets Based on Mobile Eye Tracking

Siyu Zheng, Jiaxin Zhang, Rui Zu, Yunqin Li

Subject: Computer Science And Mathematics, Analysis Keywords: Historic Streets; Environmental Attractiveness; Visual Perception; Temporal Shifts in Attention; Mobile Eye-Tracking Technology

Online: 21 May 2024 (12:16:13 CEST)

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The commercialization of historic streets constitutes a pivotal aspect of urban cultural heritage, and the comprehension of their visual perception serves as a valuable asset to urban planning and cultural conservation efforts. However, current research concerning the disparities in visual perception among diverse demographics within historic streets, as well as their spatiotemporal dynamics, remains insufficient. This study aims to utilize mobile eye-tracking technology to delve deeply into the visual perception characteristics of diverse demographics within commercialized historic streets, while also analyzing their spatiotemporal dynamics. We explore the disparities in visual perception of historic streets among groups with varying degrees of architectural knowledge and professional literacy. Through meticulous observation using mobile eye-tracking technology, we elucidate the visual perception patterns of different demographic characteristics through statistical analysis and spatiotemporal modeling. The findings reveal significant discrepancies in visual attention and perception among various groups. Participants with a higher understanding of architecture tend to focus more on architectural details and structures within the streetscape compared to those with a lower understanding, who exhibit greater interest in elements such as shops and signage. Moreover, during the process of perceiving the streetscape, participants’ eye movements transition from surrounding landscapes and historical edifices upon initial entry to the district, gradually shifting towards the commercial activities and distinctive architecture within the district. This study delves deeply into the visual perception characteristics and spatiotemporal dynamics of commercialized historic streets, providing invaluable insights for urban planning and cultural preservation endeavors. By revealing the impact of different demographic characteristics on the visual perception of historic streets, it offers new insights for urban planning and cultural heritage conservation.

Preprint ARTICLE | doi:10.20944/preprints202405.1217.v1

Demonstration of an In-Flight Entertainment System Using Power-over-Fiber

Joao B. Rosolem, Fabio R. Bassan, Marcelo Prado de Oliveira, Alexandre Barbosa dos Santos, Leonardo Martins Wollinger

Subject: Engineering, Aerospace Engineering Keywords: power over fiber; PoF; in-flight entertainment; IFE; avionics; optical fibers; high optical power

Online: 20 May 2024 (12:37:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0004.v1

Thermographic Measurements in Electrical Power Engineering – Discussion on How to Interprete the Results

Waldemar Minkina, Sławomir Gryś

Subject: Physical Sciences, Thermodynamics Keywords: electrical power system; thermographic measurements; standards in thermovision measurements; thermographic diagnostic; interpretation of thermograms

Online: 1 May 2024 (09:58:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0628.v1

Mechanism of How Plant-Based Diet (PBD) Reduces the Risk of In-Stent Restenosis (ISR) and Stent Thrombosis (ST)

Dasaad Mulijono

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Plant-based diet; lifestyle; in-stent restenosis; stent thrombosis; ISR; ST; atherosclerosis; mitochondria; telomere

Online: 9 April 2024 (08:49:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0713.v3

Vanadium Complexes with Thioanilide Derivatives of Amino Acids: Inhibition of Human Phosphatases and Specificity in Various Cell Models of Metabolic Disturbances

Grzegorz Kazek, Monika Głuch-Lutwin, Barbara Mordyl, Elżbieta Menaszek, Monika Kubacka, Anna Jurowska, Dariusz Cież, Bartosz Trzewik, Janusz Szklarzewicz, Monika A. Papież

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: vanadium complexes; phosphatases; in vitro; cells models; metabolic disorders; diabetes; insulin resistance; gluconeogenesis; NAFLD

Online: 26 February 2024 (17:23:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1393.v1

In vitro gas Production of Common Southeast Asian Grasses in Response to Variable Regrowth Periods in Vietnam

Huyen Thi Duong Nguyen, Jan Thomas Schonewille, Wilbert Frans Pellikaan, Trach Xuan Nguyen, Wouter Hendrikus Hendriks

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: tropical grasses; ruminants; nutritive values; in vitro gas production; methane production; volatile fatty acids

Online: 23 February 2024 (17:06:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0940.v1

Fibrin-Based Hydrogels with Reactive Amphiphilic Copolymers for Mechanical Adjustments Allow for Capillary Formation in 2D and 3D Environments

Svenja Wein, Carina Schemmer, Miriam Aischa Al Enezy-Ulbrich, Shannon Anna Jung, Stephan Rütten, Mark Kühnel, Danny David Jonigk, Wilhelm Jahnen-Dechent, Andrij Pich, Sabine Neuss

Subject: Chemistry And Materials Science, Biomaterials Keywords: Fibrin-based hydrogels; Cell-based angiogenesis; Copolymer integration; In vitro pre-vascularization; Biohybrid constructs

Online: 19 February 2024 (11:48:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1092.v1

Behavioral Health Services Outcomes That Matter Most to Caregivers of Children, Youth, and Young Adults with Mental Health Needs

Genevieve Graaf, Katherine Kitchens, Millie Sweeney, Kathleen C Thomas

Subject: Public Health And Healthcare, Health Policy And Services Keywords: Youth mental health; child mental health; parent support in child mental health; caregiver perspectives

Online: 15 January 2024 (06:14:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0988.v1

Computational Fluid Dynamics Simulation Study on Aerodynamic Characteristics under Unfavorable Conditions during Flight Phase in Ski Jumping

Qi HU, Weidi TANG, Yu LIU

Subject: Physical Sciences, Biophysics Keywords: computational fluid dynamics; aerodynamic characteristics; flight phase in ski-jumping; flight stability; sport performance

Online: 12 January 2024 (09:05:05 CET)

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Objective: The stability of the flight phase in ski jumping is crucial for athletes' performance and safety. This study aims to investigate the influence of unfavorable conditions on aerodynamic characteristics and flight stability through computational fluid dynamics (CFD) numerical simulations. Methods: The ski jumper and the skis are considered as a multi-body system. A detailed three-dimensional (3D) model of this multi-body system under a commonly observed posture during flight is established. The partially averaged Navier-Stokes (PANS) turbulence model is employed, and CFD simulations are conducted to predict the aerodynamic characteristics of the multi-body system under lateral environmental wind and asymmetric postures during flight phase. The conditions of asymmetric postures include yaw rotation and roll rotation. Results: (1) Lateral environmental wind generated yaw force, yaw moment, and roll moment, which influenced the lift, drag, and pitch moment of the athlete. These forces and moments were relatively small at lower wind speeds (less than 3 m/s) and became more significant at higher wind speeds (greater than 4.5 m/s). (2) Under the influence of yaw rotation or roll rotation, the multi-body system exhibited noticeable yaw force, yaw moment, and roll moment, all showing a monotonic increasing trend. Moreover, they had a significant impact on the lift, drag, and pitch moment of the multi-body system. Conclusion: (1) The influence of unfavorable conditions is complex, resulting in significant yaw force, yaw moment, and roll moment on the multi-body system. The adverse effects of roll rotation were generally greater than those of yaw rotation. (2) The multi-body system exhibited self-stabilizing tendencies in yaw and roll. This phenomenon can provide a solution to maintain flight stability by employing appropriate yaw or (and) roll rotation angles, effectively compensating for or even eliminating the adverse effects of lateral environmental wind. (3) Understanding the mechanisms of how unfavorable conditions affect the aerodynamic characteristics and stability during flight in ski jumping can provide valuable assistance for real-time prediction and decision-making during competitions, as well as scientific guidance for training athletes stable flight control and techniques and improving their sport performance.

Preprint BRIEF REPORT | doi:10.20944/preprints202401.0889.v1

Impact of Mechanical Circulatory Support Timing on Outcomes in Myocardial Infarction-Related Cardiogenic Shock: Subanalysis of the PREPARE CS Registry

Dan Mihai Prunea, Eva Bachl, Lukas Herold, Sadeek Sidney Kanoun Schnur, Sascha Pätzold, Siegfried Altmanninger-Sock, Gudrun Angelika Sommer, Theresa Glantschnig, Ewald Kolesnik, Markus Wallner, Klemens Ablasser, Heiko Bugger, Eva Buschmann, Andreas Praschk, Friedrich M. Fruhwald, Albrecht Schmidt, Dirk Von Lewinski, Gabor Toth-Gayor

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: cardiogenic shock; mechanical circulatory support; myocardial infarction; mechanical circulatory support timing; in-hospital mortality

Online: 11 January 2024 (08:10:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0484.v1

Effects of In Vitro Fermentation of Polysialic Acid and Sialic Acid on Gut Microbial Community Composition and Metabolites in Healthy Human

Zhongwei Yin, Li Zhu, Minjie Gao, Dan Yu, Zijian Zhang, Ling Zhu, Xiaobei Zhan

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Prebiotics; In vitro digestion; Fecal fermentation; Intestinal microorganism; Short-chain fatty acid; Differential metabolites

Online: 5 January 2024 (14:37:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1960.v1

The Diagnosis, Treatment, and Prevention of Glaucoma – An Update

Karen Allison, Kevin Andrew Morabito, Margaret M. DeAngelis, Deepkumar Patel

Subject: Medicine And Pharmacology, Ophthalmology Keywords: Glaucoma; epidemiology of glaucoma; open angle glaucoma; blindness; disparities in glaucoma treatment and diagnosis

Online: 28 December 2023 (02:26:28 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.1540.v1

State of the Art Technologies for High Yield Heterologous Expression and Production of Oxidoreductase Enzymes: Glucose Oxidase, Cellobiose Dehydrogenase, Horseradish Peroxidase, and Laccases in Yeasts P. pastoris and S. cerevisiae

Milica Crnoglavac Popović, Marija Stanišić, Radivoje Prodanović

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: recombinant; oxidoreductase; expression; yeasts; directed evolution; high-throughput screening; flow cytometry; in vitro compartmentalization

Online: 20 December 2023 (10:36:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0820.v1

Will Urbanization Affect the Low-Carbon Efficiency of Agriculture?—Based on Empirical Evidence from the Yellow River Basin

Xinyan Song, Chengyue Wang, Wenxin Liu

Subject: Social Sciences, Area Studies Keywords: Yellow River Basin; Low-carbon efficiency in agriculture; spatial-temporal heterogeneity; urbanization; Markov chain

Online: 13 November 2023 (15:42:37 CET)

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The improvement of agricultural low-carbon efficiency is an important path to promote the realization of the "double carbon" goal in the Yellow River Basin. In the context of rapid urbanization development, it is of great significance to explore whether the promotion of urbanization will affect the agricultural low-carbon efficiency. Based on the panel data of 75 cities in the Yellow River Basin from 2000 to 2020, this paper uses super-DEA model, three-dimensional kernel density model and Markov chain model to measure and analyze the spatio-temporal evolution of agricultural low-carbon efficiency in the Yellow River Basin, on this basis, the panel Tobit model is used to analyze the relationship between urbanization and low-carbon efficiency in agriculture. The results show that: (1) The level of agricultural low-carbon efficiency in the Yellow River Basin is low and has not reached the effective state, showing a slow downward trend in general, among which, the agricultural low-carbon efficiency in the lower reaches is higher than that in the middle reaches, and the upper reaches is the lowest. (2) The agricultural low-carbon efficiency in the Yellow River Basin has a negative trend of transferring to the low level on the whole, and tends to maintain the original state level, and it is difficult to realize the leapfrog transfer between states. Agricultural low-carbon efficiency has obvious spatial spillover effect and "club convergence" phenomenon, high efficiency area has a positive driving effect on the neighborhood area, while low efficiency area has a negative impact on the neighborhood area. (3) The level of urbanization has a significant positive impact on the low-carbon efficiency of agriculture in the upper, middle and lower reaches of the Yellow River Basin, which plays an important role in promoting the green development of agriculture. Finally, based on the above research conclusions, relevant policy recommendations were put forward, in order to provide references for promoting the improvement of low-carbon agricultural efficiency and promoting high-quality agricultural development in the Yellow River Basin.

Preprint ARTICLE | doi:10.20944/preprints202311.0577.v1

Retaining Non-EU Immigrants in Rural Areas to Sustain Depopulated Regions: Motives to Remain

Elisete Simoes Diogo

Subject: Social Sciences, Other Keywords: International immigrants; Rural Areas; Depopulated regions; Keeping people in Low density territories; Regional development

Online: 9 November 2023 (07:30:11 CET)

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Rural areas, as a system, face multiple challenges. Among these are population decline and attendant economic and social maladies namely demographic issues considering a scarce population. Pull factors for immigrants to go to other countries are known, nevertheless, to comprehend factors for remaining in rural areas after arriving could support a strategic local policy, and for an informed practice. The purpose of the study is to explore motivations shaping immigrants’ intentions to stay in the Alentejo, a depopulated region in Portugal, using a qualitative approach. Research questions are: What motivates immigrants to remain living in depopulated regions in Portugal? Furthermore, what contributions can practitioners and immigrants give for local policy and practice? Eight practitioners and fifteen non-European Union immigrants living in this region were interviewed between 2020 and 2021. Empirical data were analysed, supported by MaxQDA software. Results point out that the intention to remain in rural areas arise from a progressive construction, it is a process that immigrants experience to become motivated to stay long-term. Factors influencing the process include four components: 1. instrumental and material motivations; 2. emotional and social motivations; 3. motivations based on quality of life; and 4. motivations based on political dimensions. Components are conditioned by the availability of : stable and suitable jobs, access to decent and affordable housing, as well as quality of education and health services for their children; additionally to socio-emotional satisfaction, as family reunification, migrants network, integration and real intercultural living in the host community, close relationships to practitioners from social services; and quality of life, such as lower rents, peaceful and secure living conditions, granted a better future for their children as in any another place in Europe, associated finally to the simplified policy enabling one to become a legal citizen. Conclusions highlight implications for policy and practice, suggesting more investment for rural regions to reverse depopulation reality.

Preprint ARTICLE | doi:10.20944/preprints202311.0546.v1

Constraints on The Fault Dip Angles of Lunar Graben and Their Significance for Lunar Thermal Evolution

Kai Zhu, Jianzhong Liu, Gregory Michael, Danhong Lei, Xuejin Zeng

Subject: Environmental And Earth Sciences, Space And Planetary Science Keywords: Lunar grabens; Dips of graben-bounding faults; Displacement-length ratios; Increase in lunar radius

Online: 8 November 2023 (10:55:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0732.v1

Unlocking the Potential of Indian Pasture Legumes: Nutrition, Mineral, Gas and Methane Production Insights for Use in Semiarid Regions

Sultan Singh, Tejveer Singh, Pushpendra Koli, Uchenna Y Anele, Brijesh K Bhadoria, Mukesh Choudhary, YongLin Ren

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: animal feed; annual legumes; perennial legumes; nutritional value; minerals; in vitro fermentation; methane production

Online: 12 October 2023 (05:04:01 CEST)

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This study evaluated five annual and eleven perennial Indian pasture legumes species for their nutritive value, dry matter, mineral contents and in vitro fermentation parameters, aiming to boost their potential as animal feed. Legume species significantly differed (p<0.05) in organic matter, crud protein (CP), ether extracts, fibres, and protein fractions. Clitoria ternatea (CT) a perennial had higher (p<0.05) buffer soluble protein (477), while neutral detergent soluble protein was highest in annually grown Lablab purpureus (420 g/kg CP). Atylosia scarabaeoides (AS) had higher NSC (392 g/kg DM) than SC (367 g/kg DM). Rapidly degradable fraction (51.7 g/kg tCHO) was lower (p<0.05) than other fractions of carbohydrate. Total digestible nutrients, digestible energy and metabolisable energy varied and values were higher for Desmenthus virgatus and lowest for Stylosanthas seabrana (SSe). The NE values for lactation (NEL), maintenance (NEM) and gain (NEG) were also higher for DV (6.6, 7.95 and 4.28) and lowest for SSe (3.54, 4.24 and 0.58 kJ/g DM), respectively. dry matter intake, digestible DM (DDM) and relative feed value of legumes differed (p<0.05) with mean values of 2.22% body weight, 592 g/kg DM and 102%, respectively. Annual grasses like Dolichos biflorus, Macroptilium atropurpureum, Rhynchosia minima (RM) were found better with micro minerals compared to other perennials. In vitro dry matter degradability, partition factor, short chain fatty acids and microbial protein production of legumes varied (P<0.05) and mean values were 578 g/kg DM, 5.61 mg DDM/mL, 2.42 mm/g and 352 mg/g, respectively. Gas and CH4 production (mL/g and mL/g DDM) varied (p<0.05) being lowest gas from AS (55.5) and highest from CT-blue (141), while CH4 production was lower (p<0.05) from CT-white and AS (8.24 and 9.14) and higher from Arachis glabrata (AG) and Arachis hagenbackii (AH) (15.2 and 15.1). Methane in total gas was low for DV, RM and CT-w (8.99, 9.72 and 9.51%) and loss of DE and ME as CH4 varied (P<0.05) amongst the legumes with mean values of 4.62 and 7.86%, respectively. Based on these findings, each legume offers unique benefits, allowing for tailored combinations of annual and perennial legumes to optimize rumen feed efficiency.

Preprint ARTICLE | doi:10.20944/preprints202310.0711.v1

Two Interference Mechanisms of Identical Particles in Quantum Mechanics

Huai-Yu Wang

Subject: Physical Sciences, Quantum Science And Technology Keywords: interference in quantum mechanics; identical particle; equal wavelength interference mechanism; exchange effect interference mechanism

Online: 11 October 2023 (09:37:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1930.v1

Data Mining and Fusion Framework for In-Home Monitoring Applications

Idongesit Ekerete, Matias Garcia-Constantino, Paul McCullagh, Christopher Nugent, James McLaughlin

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: sensing solution; thermal sensor; Radar sensor; sensor fusion; data mining; in-home; machine learning

Online: 28 September 2023 (10:06:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1566.v1

Histological and Immunohistochemical Characterization of Osteoimmunological Processes in Scaffold-Guided Bone Regeneration in an Ovine Large Segmental Defect Model

Ronja Finze, Markus Laubach, Mairim Russo Serafini, Ulrich Kneser, Flavia Medeiros Savi

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: immunohistochemistry; foreign body reaction; bone defect; scaffold-guided bone regeneration; polycaprolactone; in vivo; sheep

Online: 23 August 2023 (05:29:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1552.v1

Sleep and Well-Being During Covid-19 Remote and In-Person Periods: Experiences of College Faculty and Staff with and Without Disabilities

Catherine Fichten, Samantha Wing, Georgiana Costin, Mary Jorgensen, Alice Havel, Susie Wileman, Sally Bailes, Laura Creti, Eva Libman

Subject: Social Sciences, Psychology Keywords: Covid-19; sleep; well-being; remote and in-person work; faculty and staff; disabilities

Online: 22 August 2023 (10:48:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0764.v1

Theoretical Interpretation of pH and Salinity Effect on Oil in Water Emulsion Stability Based on Interfacial Chemistry and Implications for Produced Water Demulsification

Mumuni Amadu, Adango Miadonye

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: Surface charge density; oil in water emulsion; salinity; degree of ionization; asphaltenes; produce water

Online: 12 July 2023 (07:53:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1500.v1

Magnetic Properties of Amorphous Ta/CoFeB/MgO/Ta Thin Films on Deformable Substrates with Magnetic Field Angle and Tensile Strain

Ah Hyun Jun, Young Hyun Hwang, Byeongwoo Kang, Seungwon Lee, Jiwon Seok, Jong Seong Lee, Seo Hyun Song, Byeong-Kwon Ju

Subject: Engineering, Electrical And Electronic Engineering Keywords: magnetic sensors; in-plane angle sensors; CoFeB; biaxial; four-fold; deformable; flexible; wearable; stretchable

Online: 21 June 2023 (08:16:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0501.v1

MicroRNA miR-274-5p Controls Melanotic Mass Formation and Developmental Growth by Regulating the Found-in-Neurons-JNK Signaling Axis in Drosophila

Hee Kyung Kim, Chae Jeong Kim, Daegyu Jang, Do-Hwan Lim

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Drosophila; miR-274; melanotic mass; growth; JNK signaling; JAK/STAT signaling; found-in-neurons

Online: 7 June 2023 (07:12:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0261.v1

In-Hospital Rehabilitation of Patients with COVID-19: A Retrospective Study with Propensity Score Matching

Sergey M. Konev, Elisaveta S. Koneva, Teimurazi R. Matsonashvili, Ekaterina N. Zhumanova, Danil S. Malyutin, Natalia S. Serova, Evgeny E. Achkasov, Igor V. Semenyakin, Konstantin V. Lyadov, Irina A. Mandel, Andrey I Yaroshetskiy

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: COVID-19; early rehabilitation; computed tomography; physical exercises; chest massage in an electrostatic field.

Online: 5 June 2023 (08:06:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0150.v1

Functionalizing Diatomite-Based Micro-Arc Coatings for Orthopedic Implants: Influence of TiO₂ Addition

Alexander D. Kashin, Mariya B. Sedelnikova, Pavel V. Uvarkin, Anna V. Ugodchikova, Nikita A. Luginin, Yurii P. Sharkeev, Margarita A. Khimich, Olga V. Bakina

Subject: Chemistry And Materials Science, Surfaces, Coatings And Films Keywords: Orthopedic implants; magnesium alloy; micro-arc coating; diatomite; TiO2; in vitro biocompatibility; corrosion resistance

Online: 2 June 2023 (07:51:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1303.v1

Experimental Investigation of Polymer Reinjection in Long Conduits for Material Sustainability and Cost Reduction of Enhanced Oil Recovery

Sherif Fakher, Abdelaziz Lafi Khlaifat

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: Polymer Reinjection; Material Sustainability; Polymer Transport in Porous Media; Polymer Degradation; Enhanced Oil Recovery

Online: 18 May 2023 (08:39:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1231.v1

Comparison of Digital Coaching Centers and Face-to-Face Coaching Centers in the Context of Shadow Education Institutions: Student and Teacher Perceptions and Academic Achievements of Students

Gülsüm Meço

Subject: Social Sciences, Education Keywords: Informal learning; Computers in education; Distance education and online learning; Learning communities; Mobile learning

Online: 17 May 2023 (10:31:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0942.v1

Intrinsic Coherence Length Anisotropy in Nickelates, and Some Pnictides and Chalcogenides Superconductors

Evgeny F. Talantsev

Subject: Physical Sciences, Condensed Matter Physics Keywords: nickelate superconductors; iron-based supercondcutors; superconducting coherence length; anisotropy of characteristic length in supercondcutors

Online: 12 May 2023 (11:37:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0290.v1

Estimation of the Relationship Structure of Quality of Life Mediated by Difficulty in Daily Life in Survivors of Breast Cancer: a Bayesian structural equation modeling approach

Aki Watanabe, Takayuki Kawaguchi, Ayumi Nobematsu, Satoshi Sasada, Nozomi Kanari, Tatsuya Maru, Takeshi Kobayashi

Subject: Public Health And Healthcare, Other Keywords: breast cancer; survivors; Bayesian structural equation modeling; Quality of life; Difficulty in daily life

Online: 5 May 2023 (03:58:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0997.v1

Milk Microbiota of Clinical Mastitic Cows: An Etiological Approach

Simone Baldini Lucheis, Anelise Salina, Samea Fernandes Joaquim, Simony Trevisan Guerra, Felipe Freitas Guimarães, Marcio Garcia Ribeiro, Vera Lúcia Mores Rall, Rodrigo Tavanelli Hernandes, Domingos da Silva Leite, Vera Cláudia Lorenzetti Magalhães Curci, Helio Langoni

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: bovine mastitis; milk pathogens; environmental agents; microbiological diagnosis; clinical severity scores; days in milk

Online: 26 April 2023 (14:22:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0618.v1

Thin Luminous Tracks of Particles from Electrodes with a Small Radius of Curvature in Pulsed Nanosecond Discharges in Air and Argon

Victor F. Tarasenko, Dmitry V. Beloplotov, Alexei N. Panchenko, Dmitry A. Sorokin

Subject: Physical Sciences, Fluids And Plasmas Physics Keywords: pulsed discharge in air and argon; steel needle electrodes; luminous tracks; micron-size particles

Online: 20 April 2023 (07:34:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202303.0024.v1

Mechanisms of COVID-19 Associated Pulmonary Thrombosis: A Narrative Review

Cristian-Mihail Niculae, Adriana Hristea, Ruxandra Moroti

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: COVID-19; SARS-CoV-2 infection; pulmonary in situ thrombosis; embolism; immunothrombosis; inflammation; coagulopathy

Online: 1 March 2023 (11:37:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0387.v1

New Insights in the Synthesis of High Molecular Weight Aromatic Polyamides. Improved Synthesis of Rod-Like PPTA

Guiomar Hernández, Sergio Ferrero, Helmut Reinecke, Camino Bartolomé, Jesús M. Martinez-Ilarduya, Cristina Álvarez, Ángel E. Lozano

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: polyamidation; in situ silylation; poly(p-phenylene terephthalamide (PPTA); Kevlar; NMR; DFT molecular simulation

Online: 23 January 2023 (02:00:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0353.v1

Metallurgical Quality of Cast Iron Made from Steel Scrap and Possibilities of its Improvement

Peter Futas, Alena Pribulova, Jozef Petrik, Peter Blasko, Andrea Junakova, Vladimir Sabik

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: synthetic cast iron; charge materials; steel scrap; nitrogen in cast iron iron; mechanical properties

Online: 20 December 2022 (04:05:55 CET)

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Preprint SHORT NOTE | doi:10.20944/preprints202211.0056.v1

Big Data Enabled Non-Invasive Rapid Sex Detection of Incubated Chicken Eggs

Suresh Neethirajan

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Precision Livestock Farming; Digital Agriculure; Smart Farming; In Ovo Sexing; Big Data; Artificial Intelligence

Online: 2 November 2022 (11:03:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202208.0355.v1

A Comprehensive Study of De Novo Mutations on Protein-protein Interaction Interface Provides New Insights in Developmental Delay

Dhruba Tara Maharjan, Weichen Song, Zhe Liu, Weidi Wang, Wenxiang Cai, Jue Chen, Fei Xu, Weihai Ying, Guan Ning Lin

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: developmental delay; de novo mutation; protein-protein interaction; PPI interface; protein in-teractome; PsymuKB

Online: 19 August 2022 (04:50:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0017.v1

The Relationship between Consuming Fashion and Self-Confidence on the Buying Behaviour in the Clothing Market as a Mediator

Milad Zam, Mohammadhosein Tavakoli, Hasan Ramezanian, Amin Rezasoltani

Subject: Business, Economics And Management, Marketing Keywords: Interest in modem personal taste; utilitarianism; new fashion products; self-confidence; fashion buying behaviour

Online: 1 August 2022 (09:40:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0063.v1

Colorectal Cancer Chemoprevention by S-Allyl Cysteine-Caffeic Acid Hybrids: Pro-apoptotic Effect, Anti-inflammatory, in Vitro/in Silico Antioxidant, Docking and Drug-Likeness Studies

Angie Herrera Ramirez, Andres F. Yepes-Pérez, Jorge Quintero-Saumeth, Gustavo Moreno Quintero, Tonny Naranjo, Wilson Cardona-G

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: S-allylcysteine; caffeic acid; hybrid compounds; in silico studies; colorectal cancer; cell death; apoptosis

Online: 7 April 2022 (14:16:48 CEST)

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Conventional chemotherapy for colorectal cancer (CRC) gives only a small increase in patient survival, since it is often diagnosed in late stages, when tumor has disseminated to other organs. Besides, it is common to observe that malignant cells acquire tumor escape mechanisms which leads to therapy resistance. Considering these facts, the discovery of new molecules with therapeutic potential has become an invaluable tool in chemoprevention. In this context, we previously evaluated two hybrids (SAC-CAFA-MET and SAC-CAFA-PENT) which exhibited selective cytotoxicity against SW480, with better results than the conventional chemotherapeutic agent (5-fluorouracil; 5-FU). Here, we investigated a little deeper in the possible mechanism of these molecules to identify potential therapeutic alternatives for the treatment of CRC. Both compounds induced cell damage and reduced ROS formation. Further evaluations showed that SAC-CAFA-MET induces cell death independent from caspases and p53, but probably mediated by the negative regulation of the proapoptotic Bcl-2. In addition, the lack of activation of caspase 8 and the positive regulation of caspase 3 induced by SAC-CAFA-PENT suggest this compound acts through an apoptotic mechanism, probably initiated by intrinsic pathway. Besides, the down regulation of IL-6 by SAC-CAFA-PENT suggests it also induces a significant anti-inflammatory process. In addition, docking studies would suggest caspase-3 modulation as the primary mechanism by which hybrids elicits apoptosis in human colorectal adenocarcinoma SW480. Meanwhile, DFT calculations suggest that hybrids would produce effects in modulation of ROS in SW480 cells via hydrogen atom transfer pathway (HAT). Finally, both, SAC-CAFA-MET and SAC-CAFA-PENT displayed a favorable pharmacokinetic profile. The current work highlights the potential of the lead compounds SAC-CAFA-MET and SAC-CAFA-PENT as potential agents for colorectal cancer chemoprevention.

Preprint ARTICLE | doi:10.20944/preprints202204.0028.v1

Divalent Yb Doped Silica Glass and Fiber with High Quantum Efficiency for White Light Source

Changming Xia, Jiantao Liu, Zhiyun Hou, Guiyao Zhou

Subject: Physical Sciences, Optics And Photonics Keywords: Yb2+ doped glass; fiber laser; visible-infrared lasers; white light source; rod in tube

Online: 6 April 2022 (04:04:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0329.v1

Plagiarism Detection in the Bengali Language: A Text Similarity-Based Approach

Satyajit Ghosh, Aniruddha Ghosh, Bittaswer Ghosh, Abhishek Roy

Subject: Computer Science And Mathematics, Analysis Keywords: Plagiarism Detection; Plagiarism checker for Bengali text; Bengali Literature Corpus; OCR in Bengali text

Online: 24 March 2022 (09:36:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0522.v1

Analysis of a Relaxation Process Caused by the Load Variation Adapted on the Basis of Second Order Electrical Model

Guzel Nikishina, Evgeny Denisov

Subject: Engineering, Electrical And Electronic Engineering Keywords: lithium battery; electrochemical power sources; diagnostics; battery management system; load variation; in situ method

Online: 31 December 2021 (12:59:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0425.v1

Bioaccessibility of Antioxidants in Blackcurrant Juice After Treatment Using Supercritical Carbon Dioxide

Urszula Trych, Magdalena Buniowska, Sylwia Skąpska, Ireneusz Kapusta, Krystian Marszałek

Subject: Chemistry And Materials Science, Food Chemistry Keywords: bioaccessibility; supercritical carbon dioxide; blackcurrant; vitamin C; anthocyanins; antioxidant activity; in vitro digestion model

Online: 27 December 2021 (11:24:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0185.v2

Can WiMAX IEEE802 Be Used to Resolve Last-Mile Connectivity Issues in Botswana?

Malebogo Mokeresete, Bukohwo Michael Esiefarienrhe

Subject: Computer Science And Mathematics, Information Systems Keywords: WiMAX IEEE 802.16e; National Broadband Project; rural area connectivity; Connectivity challenges in developing countries

Online: 18 October 2021 (12:55:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0290.v1

Changes in Alienation in Physical Education Classes, School Happiness, and Future Healthy Life Expectancy After the COVID-19 Pandemic in Korean Adolescents

Seung-Man Lee, Jung-In Yoo, Hyun-Su Youn

Subject: Medicine And Pharmacology, Other Keywords: adolescents; alienation in PE class; school happiness; future healthy life expectancy; COVID-19 pandemic

Online: 16 September 2021 (13:55:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0255.v1

Detecting the Institutional Mediation of Push–Pull Factors on International Students’ Satisfaction during the COVID-19 Pandemic

Dian-Fu Chang, Wen-Ching Chou

Subject: Social Sciences, Education Keywords: COVID-19; effects; educational systems; change in higher education; international students; push–pull theory

Online: 15 September 2021 (11:45:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0194.v1

Exploring the Effect of College Students’ Civic Engagement on Transferable Capabilities during the COVID-19 Pandemic

Dian-Fu Chang, Tsun Ning Chang, Chia Chi Chen

Subject: Social Sciences, Education Keywords: civic engagement; COVID 19; change in higher education; educational systems; effects; SEM; transferable capabilities

Online: 13 September 2021 (08:31:05 CEST)

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Working Paper ARTICLE

Nonlinear Control of Photonic Higher-Order Topological Bound States in the Continuum

Zhichan Hu Hu, Domenico Bongiovanni, Dario Jukić, Ema Jajtić, Shiqi Xia, Daohong Song, Jingjun Xu, Roberto Morandotti, Hrvoje Buljan, Zhigang Chen

Subject: Physical Sciences, Acoustics Keywords: Higher-order topological insulators; topological bound states in the continuum; nonlinear optics; SSH lattice

Online: 28 July 2021 (09:35:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0459.v1

User Monitoring in Autonomous Driving System Using Gamified Task: A Case for vr/AR in-Car Gaming

Joseph K. Muguro, Pringgo Widyo Laksono, Yuta Sasatake, Kojiro Matsushita, Minoru Sasaki

Subject: Engineering, Automotive Engineering Keywords: Autonomous Driving System; In-Car Gaming; Driver Behavior; Driving Related Tasks; 3D-VR/AR

Online: 17 June 2021 (12:29:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0192.v1

Table in Gradshteyn and Ryzhik: Derivation of definite integrals of a Hyperbolic Function

Robert Reynolds, Allan Stauffer

Subject: Computer Science And Mathematics, Mathematics Keywords: entries in Gradshteyn and Rhyzik, Lerch function, Logarithm function, Contour Integral, Cauchy, Infinite Integral

Online: 10 May 2021 (13:51:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0032.v1

Cellular Prion Protein and Amyloid – β Oligomers in Alzheimer's Disease – There Are Connections?

Naomi Hachiya, Michał Fułek, Katarzyna Zajączkowska, Donata Kurpas, Elżbieta Trypka, Jerzy Leszek

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Alzheimer’s disease; cellular prion protein; amyloid β and PrP interaction in Alzheimer’s; BACE1; Aβ

Online: 5 May 2021 (10:45:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0117.v1

A Multiscale Investigation on the Thermal Transport in Polydimethylsiloxane Nanocomposites: Graphene vs Borophene

Alessandro Di Pierro, Bohayra Mortazavi, Hamidreza Noori, Timon Rabczuk, Alberto Fina

Subject: Chemistry And Materials Science, Biomaterials Keywords: Thermal transport in nanocomposites; interfacial thermal conductance; graphene; borophene; multiscale modelling of thermal transport

Online: 6 January 2021 (13:26:46 CET)

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Working Paper REVIEW

An Overview on Dialysis on Pregnancy

Roberta Costanza Bruno Vecchio, Valentina Del Negro, Giovanna Savastano, Maria Grazia Porpora, Maria Grazia Piccioni

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Dyalisis in pregnancy; End stage renal disease; haemodyalisis; peritoneal dyalisis; intensive dyalisis regimen; preeclampsia

Online: 30 December 2020 (16:55:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0714.v1

Towards a Biomanufactory on Mars

Aaron Berliner, Jacob M. Hilzinger, Anthony J. Abel, Matthew McNulty, George Makrygiorgos, Nils J.H. Averesch, Soumyajit Sen Gupta, Alexander Benvenuti, Daniel Caddell, Stefano Cestellos-Blanco, Anna Doloman, Skyler Friedline, Desiree Ho, Wenyu Gu, Avery Hill, Paul Kusuma, Isaac Lipsky, Mia Mirkovic, Jorge Meraz, Vince Pane, Kyle B. Sander, Fengzhe Shi, Jeffrey M. Skerker, Alexander Styer, Kyle Valgardson, Kelly Wetmore, Sung-Geun Woo, Yongao Xiong, Kevin Yates, Cindy Zhang, Shuyang Zhen, Bruce Bugbee, Devin Coleman-Derr, Ali Mesbah, Somen Nandi, Robert W. Waymouth, Peidong Yang, Craig S. Criddle, Karen A. McDonald, Amor A. Menezes, Lance C. Seefeldt, Douglas S. Clark, Adam P. Arkin

Subject: Engineering, Automotive Engineering Keywords: space systems bioengineering; human exploration; mars; in situ resource utilization; life support systems; biomanufacturing

Online: 29 December 2020 (07:57:37 CET)

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Working Paper ARTICLE

Design and Implementation of a Co-Simulation Framework for Testing of Automated Driving Systems

Demin Nalic, Aleksa Pandurevic, Arno Eichberger, Branko Rogic

Subject: Engineering, Automotive Engineering Keywords: ADAS simulation; scenario generation; automated driving; Testing; innovation in mobility; self-driving cars; transportation

Online: 7 December 2020 (11:24:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0737.v1

The Sensor Hub for Detecting the Developmental Characteristics in Reading in Children on a White vs. Coloured Background/Coloured Overlays

Tamara Jakovljević, Milica Janković, Andrej Savić, Ivan Soldatović, Petar Todorovic, Tadeja Jere Jakulin, Gregor Papa, Vanja Ković

Subject: Social Sciences, Psychology Keywords: sensorhub; reading in children; developmental differences; background colours; overlay colours; eeg; ecg; eda; eyetracking

Online: 2 December 2020 (15:34:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0514.v1

In-Stream Tidal Energy Resources in Macrotidal Non-Cohesive Sediment Environments: Effect of Morphodynamic Changes at Two Bays in the Upper Gulf of California

Anahí Bermúdez-Romero, Vanesa Magar, Markus S. Gross, Victor M. Godínez, Manuel López-Mariscal, Julio Candela

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: In-Stream Tidal Energy Resources; Macro-Tidal Environments; Marine Renewable Energy; Gulf of California

Online: 19 November 2020 (14:18:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0492.v1

Direct and Label-Free Monitoring of Albumin in 2D Fatty Liver Disease Model using Plasmonic Nanogratings.

Gerardo A. Lopez-Muñoz, Ma. Alejandra Ortega, Ainhoa Ferret-Miñana, Francesco De Chiara, Javier Ramón-Azcón

Subject: Chemistry And Materials Science, Biomaterials Keywords: 2D fatty liver in vitro model; Blu-Ray disc; Plasmonic Nanomaterials; Label-Free Biosensing

Online: 19 November 2020 (07:30:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202004.0161.v2

High Throughput Virtual Screening to Discover Inhibitors of the Main Protease of the Coronavirus SARS-CoV-2

Olujide O. Olubiyi, Maryam Olagunju, Monika Keutmann, Jennifer Loschwitz, Birgit Strodel

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: COVID-19; docking; drug repurposing; natural products; in silico drug design; viral replication inhibition

Online: 1 June 2020 (02:42:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0051.v1

Mapping the Spread of COVID-19 Outbreak in India

Vanshika Bidhan, Bhavini Malhotra, Mansi Pandit, Narayanan Latha

Subject: Public Health And Healthcare, Health Policy And Services Keywords: COVID-19; Data mining; Infection in India; R package; State- wise analysis; Statistical analysis

Online: 5 May 2020 (02:28:26 CEST)

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Background & Objectives: The global pandemic caused by novel coronavirus SARS-CoV-2 has claimed several lives worldwide. With the virus gathering rapid spread, the world has witnessed increasing number of confirmed cases and mortality rate, India is not far behind with approximately 37,000 affected individuals as on May 2, 2020. The ongoing pandemic has raised several questions which need to be answered by analysis of transmission of the infection. The data has been collected on daily basis from WHO and other sites. We have represented the data collated graphically using statistical packages, R and other online softwares. The present study provides a holistic overview of the spread of COVID-19 infection in India. Methods: Real-time data query was done based on daily observations using publicly available data from reference websites for COVID-19 and other government official reports for the period (15^th February, 2020 to April 28^th, 2020). Statistical analysis was performed to draw important inferences regarding COVID-19 trend in India. Results: A decrease in growth rate of cases due to COVID-19 in India post lockdown and improvement in recovery rate during the month of April was identified. The case fatality rate was estimated to be 3.22% of the total reported cases. State-wise analysis revealed a deteriorating situation in states of Maharashtra and Gujarat among others as cases continued to increase rapidly there. A positive linear correlation between the number of deaths and total cases and exponential relation between population density and number of cases reported per square km was established. Interpretation & Conclusions: Despite early preventive measures taken up by the Government of India, the increasing number of cases in India is a concern. This study compiles state-wise and district-wise data to report the daily conﬁrmed cases, case fatalities and strategies adopted in the form of case studies. Understanding the transmission spread of SARS-CoV-2 in a diverse and populated country like India will be crucial in assessing the effectiveness of control policies towards the spread of COVID-19 infection.

Preprint ARTICLE | doi:10.20944/preprints202002.0262.v1

Forward Link Optimization for the Design of VHTS Satellite Networks

Flor G. Ortiz-Gomez, Ramón Martínez, Miguel A. Salas-Natera, Andrés Cornejo, Salvador Landeros-Ayala

Subject: Engineering, Electrical And Electronic Engineering Keywords: CCM; CINR; Cost per Gbps in orbit; Multibeam Satellite Communications; System Optimization; VCM; VHTS

Online: 18 February 2020 (08:53:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0331.v1

Psychological Wellbeing in Adolescents with Leukaemia: A Comparative Study with Typical Development Peers

Marta Tremolada, Livia Taverna, Ilaria Tamara Chiavetta, Sabrina Bonichini, Maria Caterina Putti, Alessandra Biffi

Subject: Social Sciences, Psychology Keywords: children; adolescents; leukaemia; in treatment; healthy peers; life perceptions; hope; psychological wellbeing; cognitive problems

Online: 25 December 2019 (03:21:27 CET)

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Preprint REVIEW | doi:10.20944/preprints201912.0065.v1

A Systematic Literature Review of Research Methodologies Used for Evaluation of Augmented Reality Based Learning Applications

Mehreen Sirshar, Haleema Sadia Baig, Syeda Hafsa Ali

Subject: Engineering, Control And Systems Engineering Keywords: augmented reality; mixed reality; learning applications; SLR; AR evaluation; research methods; AR in education

Online: 5 December 2019 (08:54:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints201909.0269.v1

Contesting the Geneticization Thesis in Human Reproduction: Dealing with Spiral Shaped Processes and Technoscientific Imaginaries

Ido Alon, Jose Guimon, Rosa Urbanos-Garrido

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: assisted reproductive technologies; In-Vitro Fertilization; Delphi; geneticization; Preimplantation Genetic Diagnosis; diffusion of innovation

Online: 24 September 2019 (05:32:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0302.v1

Evolution and Collapse of Ejidos in Mexico: How Far is Communal Land Used for Urban Development?

Melissa Schumacher, Pamela Durán-Díaz, Anne Kristiina Kurjenoja, Eduardo Gutiérrez-Juárez, David A. González-Rivas

Subject: Arts And Humanities, Architecture Keywords: land tenure in Mexico; ejido system; land expropriation; gated-communities; San Andrés Cholula; Ocoyucan

Online: 26 July 2019 (16:40:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0421.v1

Circulating Tumor Cells Develop Resistance to TRAIL-Induced Apoptosis through Autophagic Removal of Death Receptor 5: Evidence from an In Vitro Model

Julianne D. Twomey, Baolin Zhang

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: circulating tumor cells; CTCs; breast cancer; metastasis; death receptor; TRAIL; apoptosis; in vitro model

Online: 19 November 2018 (06:44:04 CET)

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