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Preprint ARTICLE | doi:10.20944/preprints202304.1265.v1

Nucleolar Stress-Induced Membrane-Less Organelles: Proteome Analysis through the Prism of Liquid-Liquid Phase Separation

Yakov I. Mokin, Anastasia A. Gavrilova, Anna S. Fefilova, Irina M. Kuznetsova, Konstantin K. Turoverov, Vladimir N. Uversky, Alexander V. Fonin

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: amyloid bodies; intrinsically disordered protein; liquid-liquid phase separation; membrane-less organelle; nuclear stress bodies; nucleolar biomolecular condensates

Online: 30 April 2023 (05:18:24 CEST)

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Preprint DATA DESCRIPTOR | doi:10.20944/preprints202304.1125.v1

Quantitative Metabolomic Dataset of Avian Eye Lenses

Ekaterina A. Zelentsova, Sofia S. Mariasina, Vadim V. Yanshole, Lyudmila V. Yanshole, Nataliya A. Osik, Kirill A. Sharshov, Yuri P. Tsentalovich

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: quantitative metabolomics; NMR spectroscopy; eye lens; birds

Online: 28 April 2023 (06:06:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1109.v1

Classical Solutions for the Generalized Kawahara-KdV System

S. Georgiev, A. Boukarou, K. Bouhali, Kh. Zennir, H. Elkhair, E. Hassan, A. Alfedeel, A. Alarfaj

Subject: Physical Sciences, Mathematical Physics Keywords: Fractional derivatives; Generalized Kawahara-KdV system; existence; classical solution.

Online: 28 April 2023 (04:39:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0182.v1

Role of Non-structural Sugar Metabolism in Regulating Tuber Dormancy in White Yam (Dioscorea rotundata)

Jeremiah S. Nwogha, Wosene G Abtew, Muthurajan Raveendran, Happiness O Oselebe, Jude E Obidiegwu, Cynthia A Chilaka, Amirtham D Domodarasamy

Subject: Biology And Life Sciences, Plant Sciences Keywords: Sugars; metabolism; yam; tuber; genotypes; dormancy; regulation

Online: 10 January 2023 (10:24:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0505.v1

Redrawing HER Volcano with Interfacial Processes – the Role of Hydrogen Spillover in Boosting H₂ Evolution in Alkaline Media

Sanjin J. Gutić, Dino Metarapi, Aleksandar Z. Jovanović, Goitom K. Gebremariam, Ana S. Dobrota, Bojana Nedić Vasiljević, Igor A. Pašti

Subject: Chemistry And Materials Science, Electrochemistry Keywords: hydrogen evolution reaction; hydrogen spillover; interfacial processes; supported catalysts; reduced graphene oxide; Kinetic Monte Carlo; volcano curve; hydrogen adsorption

Online: 28 November 2022 (08:37:23 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202206.0137.v1

FAIR Sharing of Reproducible Models of Epidemic and Pandemic Forecast

Kausthubh Ramachandran, Matthias König, Martin Scharm, Tung V. N. Nguyen, Henning Hermjakob, Dagmar Waltemath, Rahuman S. Malik Sheriff

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: FAIR; epidemiology; models; pandemic forecast; SIR modelling; standards

Online: 9 June 2022 (07:55:55 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0022.v1

Immune Escape Associated with RBD Omicron Mutations and SARS-CoV-2 Evolution Dynamics

Alexander Kudryavtsev, Anna V. Vakhrusheva, Valery Novoseletsky, Marine Bozdaganyan, Konstantin V. Shaitan, Mikhail P. Kirpichnikov, Olga S. Sokolova

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; COVID-19; Omicron; bioinformatics; immune escape; RBD mutations; vaccine development

Online: 1 June 2022 (14:12:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0214.v1

Explainable AI-based Alzheimer’s Prediction and Management Using Multimodal Data

Sobhana Jahan, Kazi Abu Taher, M Shamim Kaiser, Mufti Mahmud, Md. Sazzadur Rahman, A. S. M. Sanwar Hosen, In-Ho Ra

Subject: Engineering, Control And Systems Engineering Keywords: Machine learning; Dementia; Data-level fusion

Online: 15 March 2022 (12:31:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0110.v2

Cocoa Extract Exerts Sex-Specific Effects in an Aggressive Hyper-Glycemia Model: A Pilot Study

Kathryn C. Racine, Lisard Iglesias-Carres, Jacob A. Herring, Mario G. Ferruzzi, Colin D. Kay, Jeffery S. Tessem, Andrew P. Neilson

Subject: Biology And Life Sciences, Food Science And Technology Keywords: BTBR; ob/ob; type-2 diabetes; flavanol; insulin; beta cell

Online: 31 January 2022 (18:09:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0421.v1

Changes in Brain Volume Resulting from Cognitive Intervention by Means of the Feuerstein Instrumental Enrichment Program in Older Adults with Mild Cognitive Impairment (MCI): A Pilot Study

Tzvi Dwolatzky, Rafi S. Feuerstein, David Manor, Shlomit Cohen, Haim Devisheim, Michael Inspector, Ayelet Eran, David Tzuriel

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Brain morphometry; Magnetic Resonance Imaging; Cognition; Mild cognitive impairment; Feuerstein Instrumental Enrichment; Structural Cognitive Modifiability; Mediated Learning Experience

Online: 27 October 2021 (15:21:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0102.v1

Genome-wide Investigation and Expression Profiles of Heat Shock Transcription Factor (HSF) Gene Family in Maize (Zea mays L.) under Different Growth Stages and Abiotic Stress Conditions

Saqlain Haider, Shazia Rehman, Yumna Ahmad, Ali Raza, Javaria Tabassum, Talha Javed, Hany S. Osman, Tariq Mahmood

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: abiotic stress; HSFs; genomics; gene ontology; maize breeding; protein 3D structures

Online: 6 September 2021 (13:57:37 CEST)

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Heat shock transcription factors (HSFs) participate in regulating many environmental stress responses and biological processes in plants. Maize (Zea mays L.) is a major cash crop that is grown worldwide. However, the growth and yield of maize are affected by several adverse environmental inputs. Therefore, investigating the factors that regulate maize growth and development and resistance to abiotic stress is an essential task for developing stress-resilient maize varieties. Thus, a comprehensive genome-wide identification analysis was performed to identify HSFs in the maize genome. The current study identified 25 ZmHSFs, randomly distributed throughout the maize genome. Phylogenetic analysis revealed that ZmHSFs are divided into three classes and 13 sub-classes. Gene structure and protein motif analysis supported the results obtained through the phylogenetic analysis. Domain analysis showed the DNA-binding domain to be the most conserved region of ZmHSFs. Segmental duplication is shown to be responsible for the expansion of ZmHSFs. Most of the ZmHSFs are localized inside the nucleus, and the ZmHSFs which belong to the same group show similar physio-chemical properties. The 3D structures revealed comparable conserved ZmHSFs protein structures. RNA-seq analysis revealed a major role of class A HSFs including, ZmHSFA-1a and ZmHSFA-2a in all the maize growth stages, i.e., seed, vegetative, and reproductive development. Furthermore, ZmHSFs displayed an obvious spatiotemporal expression. Under abiotic stress conditions (heat, drought, cold, UV, and salinity), members of class A and B ZmHSFs are induced. Gene ontology (GO) annotation analysis indicated a major role of ZmHSFs in resistance to environmental stress and regulation of primary metabolism. Further, the protein-protein interaction analysis showed that ZmHSFs interact with several molecular chaperons and major stress-responsive proteins. To summarize, this study provides novel insights for functional studies on the ZmHSFs in maize breeding programs.

Preprint CASE REPORT | doi:10.20944/preprints202107.0340.v1

Noninvasive Optical Monitoring of Cerebral Blood Flow and EEG Spectral Responses after Severe Traumatic Brain Injury: A Case Report

Chien-Sing Poon, Benjamin Rinehart, Dharminder S. Langri, Timothy M. Rambo, Aaron J. Miller, Brandon Foreman, Ulas Sunar

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: cerebral blood flow and oxygenation; diffuse correlation spectroscopy; EEG; traumatic brain in-jury; neurointensive care unit; neuromonitoring

Online: 14 July 2021 (15:19:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0276.v1

Operando in-SEM Study of Micro-Deformation and Fracture Behaviour of Carbonized Elastomer-Based Composites

Eugene S. Statnik, Semen D. Ignatyev, Andrey A. Stepashkin, Alexey I. Salimon, Dilyus Chukov, Sergey D. Kaloshkin, Alexander M. Korsunsky

Subject: Engineering, Automotive Engineering Keywords: composite materials; carbonized elastomeric matrices; C/SiC fillers; μ-DENT; in situ tensile test; Deben Microtest; Tescan Vega 3; NanoScan-4D; Digital Image Correlation (DIC).

Online: 11 December 2020 (11:31:29 CET)

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The carbonized elastomer-based composites (CECs) possess a number of attractive features in terms of thermomechanical and electromechanical performance, durability in aggressive media and facile net-shape formability, but their relatively low ductility and strength limit their suitability for structural engineering applications. Prospective applications such as structural elements of MEMS can be envisaged, since smaller principal dimensions reduce the susceptibility of components to residual stress accumulation during carbonization, and to brittle fracture in general. We report the results of operando in-SEM study of micro-deformation and fracture behavior of CECs based on NBR elastomeric matrices filled with carbon and silicon carbide. Nanostructured carbon composite materials were manufactured via compounding of elastomeric substance with carbon and SiC fillers using mixing rolling mill, vulcanization, and low-temperature carbonization. Double Edge Notched Tensile (DENT) specimens of vulcanized and carbonized elastomeric composites were subjected to in situ tensile testing in the chamber of the scanning electron microscope (SEM) Tescan Vega 3 using Deben Microtest 1 kN Tensile Stage. The series of acquired SEM images were analyzed by means of Digital Image Correlation (DIC) using Ncorr open source software to map the spatial distribution of strain. These maps were correlated with Finite Element Modelling (FEM) simulations to refine the values of elastic moduli. Besides, the elastic moduli were derived from unloading curve nanoindentation hardness measurements carried out using NanoScan-4D tester and interpreted using the Oliver-Pharr method. Carbonization causes significant increase of elastic moduli from 0.86 ± 0.07 to 14.12 ± 1.20 GPa for the composite with graphite and carbon black fillers. Nanoindentation measurements yield somewhat lower values, namely, 0.25 ± 0.02 GPa and 9.83 ± 1.10 GPa before and after carbonization respectively. The analysis of fractography images suggests that crack initiation, growth and propagation may occur both at the notch stress concentrator and relatively far from the notch. Possible causes of such response are discussed, namely, (1) residual stresses introduced by processing; (2) shape and size of fillers; and (3) the emanation and accumulation of gases in composites during carbonization.

Preprint REVIEW | doi:10.20944/preprints202010.0614.v1

Social Capital Contributions to Food Security: A Comprehensive Literature Review

Saeed Nosratabadi, Nesrine khazami, Marwa Ben Abdallah, Zoltan Lackner, Shahab S. Band, Amir Mosavi, Csaba Mako

Subject: Social Sciences, Safety Research Keywords: social capital; food security; hunger; knowledge sharing; social networks

Online: 29 October 2020 (13:24:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0397.v1

Group A Rotavirus Gastroenteritis in Orphaned Leopardus Tigrinus and Leopardus Pardalis (CARNIVORA: FELIDAE) in the Eastern Amazon

Áurea M. Gabriel, Washington L.A. Pereira, Klena S. Silva, Lorena Souza, Akim F.S. Nobre, Joana D’Arc Mascarenhas, Alexandre da C. Linhares

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: group A rotavirus gastroenteritis; emerging zoonotic viral diseases; leopardus tigrinus and leopardus pardalis; endangered neotropical rain forest felids; rehabilitation of injured or orphaned native wild cats

Online: 19 August 2020 (08:06:31 CEST)

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Working Paper ARTICLE

Fold-change-Specific Enrichment Analysis (FSEA): Quantification of Transcriptional Response Magnitude for Functional Gene Groups

Daniil S. Wiebe, Nadezhda A. Omelyanchuk, Aleksei M. Mukhin, Ivo Grosse, Sergey A. Lashin, Elena V. Zemlyanskaya, Victoria V. Mironova

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Gene expression; Gene Ontology; Enrichment analysis; Transcriptomics

Online: 2 April 2020 (11:51:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0339.v1

Compatibility of Aerial and Terrestrial LiDAR for Quantifying Forest Structural Diversity

Elizabeth A. LaRue, Franklin W. Wagner, Songlin Fei, Jeff W. Atkins, Robert T. Fahey, Chris M. Gough, Brady S. Hardiman

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: ALS; forest ecology; forest structure; NEON; macrosystems biology; TLS

Online: 23 March 2020 (06:42:29 CET)

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Working Paper ARTICLE

In Arabidopsis thaliana Heterosis Level Varies among Individuals in an F₁ Hybrid Population

Hasan Mehraj, Takahiro Kawanabe, Motoki Shimizu, Naomi Miyaji, Ayasha Akter, Elizabeth S. Dennis, Ryo Fujimoto

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: heterosis; hybrid vigor; transcriptome

Online: 7 March 2020 (03:05:56 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202002.0057.v1

Hierarchically Porous Silk/Activated-Carbon Composite Fibers for Adsorption and Repellence of Volatile Organic Compounds

Aled D. Roberts, Jet-Sing M. Lee, Adrián Magaz, Martin W. Smith, Michael Dennis, Nigel S. Scrutton, Jonny J. Blaker

Subject: Chemistry And Materials Science, Biomaterials Keywords: porous fibers; activated carbon; ice-templating; ice segregation induced self-assembly; silk fibroin; wet spinning; solution blow spinning

Online: 5 February 2020 (10:38:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints201905.0294.v1

Soil Probiotic Utilizes Plant and Pollinator Transport for Territorial Expansion

Da-Ran Kim, Gyeongjun Cho, Chang-Wook Jeon, David M. Weller, Linda S. Thomashow, Timothy C. Paulitz, Youn-Sig Kwak

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: core microbiota; ecosphere; streptomyces; strawberry; three kingdom partnership

Online: 24 May 2019 (11:55:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0521.v1

Phosphorus Budget for a Forested-Agricultural Watershed Influenced by East-Asian Summer Monsoon

Arif Reza, Jaesung Eum, Sungmin Jung, Youngsoon Choi, Changwon Jang, Kiyong Kim, Jeffrey S. Owen, Bomchul Kim

Subject: Environmental And Earth Sciences, Environmental Science Keywords: phosphorus; nutrient budget; non-point source pollution; Korea; monsoon climate

Online: 21 November 2018 (07:28:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0483.v1

Suppression of IFN-g Production in Murine Splenocytes by Histamine Receptor Antagonists

Miho Kamei, Yukie Otani, Hidenori Hayashi, Tadaho Nakamura, Kazuhiko Yanai, Kazuyuki Furuta, Satoshi Tanaka

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: IFN-γ; histamine; splenocyte; histamine H1 receptor, histidine decarboxylase

Online: 20 November 2018 (05:35:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints201807.0494.v1

Early Mobility in the Hospital: Lessons Learned from the STRIDE Program

S. Nicole Hastings, Ashley L. Choate, Elizabeth P. Mahanna, Theresa A. Floegel, Kelli D. Allen, Courtney H. Van Houtven, Virginia Wang

Subject: Public Health And Healthcare, Nursing Keywords: mobility; hospitalization; older adults; implementation

Online: 25 July 2018 (16:03:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0323.v2

Salt Stress Induces Non-CG Methylation in Coding Regions of Barley Seedlings (Hordeum vulgare)

Moumouni Konaté, Michael J. Wilkinson, Benjamin T. Mayne, Stephen M. Pederson, Eileen S. Scott, Bettina Berger, Carlos M. Rodriguez Lopez

Subject: Biology And Life Sciences, Plant Sciences Keywords: epigenetics; differentially methylated markers (DMMs); LEAVES; roots; DNA methylation; salinity stress; barley

Online: 15 June 2018 (06:10:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0294.v1

New Compositions of Metal-Working Coolants for Brass Rolling

Anatoly P. Avdeenko, Mykhailo V. Fedorynov, Predrag V. Dašić, Raul Turmanidze, Konstantin S. Burmistrov, Nikolay V. Toropin, Svetlana A. Konovalova

Subject: Engineering, Mechanical Engineering Keywords: metal-working coolants (MWC); lubricant; rolling; strip rolling; waste recycling; sunflower oil production

Online: 23 April 2018 (12:36:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201802.0048.v1

Body Weight Loss, Tissue Wasting and Shortened Lifespan in Late Middle-aged Mice on Imbalanced Essential/Non-essential Amino Acids Diet

Giovanni Corsetti, Evasio Pasini, Claudia Romano, Riccardo Calvani, Anna Picca, Emanuele Marzetti, Vincenzo Flati, Francesco S. Dioguardi

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Aging, Nutrition, Diet, Muscle atrophy, Body wasting, Food choice

Online: 5 February 2018 (23:43:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints201708.0096.v1

The Extracellular Domain of Human High Affinity Copper Transporter (hNdCTR1), Synthesized by E. coli Cells, Chelates Silver and Copper Ions in Vivo

Tatiana P. Sankova, Iurii A. Orlov, Andrey N. Saveliev, Demid A. Kirilenko, Polina S. Babich, Pavel N. Brunkov, Ludmila V. Puchkova

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: CTR1 metal-binding extracellular domain cloning; copper/silver chelation; E. coli filamentous growth; secondary silver nanoparticles formation

Online: 27 August 2017 (11:56:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201704.0024.v1

Variations of Carbon Monoxide Concentrations in the Megacity of São Paulo from 2000 to 2015 in Different Time Scales

José Roberto Rozante, Vinícius Rozante, Débora S. Alvim, Antônio Ocimar Manzi, Júlio Barboza Chiquetto, Monica Siqueira D'Amelio, Demerval Soares Moreira

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: carbon monoxide; diurnal cycle; seasonal cycle; urban pollution; pollution trends

Online: 4 April 2017 (11:14:07 CEST)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints201608.0180.v1

Low Cost and Flexible UAV Deployment of Sensors

Lars Yndal Sørensen, Lars Toft Jacobsen, John Paulin Hansen

Subject: Engineering, Electrical And Electronic Engineering Keywords: UAV; Drone; monitoring; Multisensor; platform; software framework; beacons

Online: 19 August 2016 (10:42:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1535.v1

Analysis of MLKL, RIP1, and RIP3 Immunostaining Markers in Human Liver Tissue from Fatal Yellow Fever Cases: Insights into Necroptosis

Vanessa do Socorro Cabral Miranda, Luiz Fabio Magno Falcao, Jeferson da Costa Lopes, Hellen Thais Fuzii, Marcos Luiz Gaia Carvalho, Arnaldo Jorge Martins Filho, Ana Cecilia Ribeiro Cruz, Raimunda S. S. Azevedo, Jorge R. Sousa, Mayumi Duarte Wakimoto, Pedro Fernando da Costa Vasconcelos, Juarez Antônio Simões Quaresma

Subject: Medicine And Pharmacology, Tropical Medicine Keywords: Yellow Fever; Necroptosis; liver parenchyma

Online: 22 August 2024 (05:53:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1009.v1

Cepharanthin®, an Alkaloid Mixture Derived from Stephania cephalantha Hayata Suppresses the Activation of T-lymphocytes and the Inflammatory Response of Epithelial Cells in In Vitro Oral Lichen Planus Model

Ryo Shiraishi, Yuske Komiyama, Yoshiaki Kitsukawa, Aya Koike, Toshiki Hyodo, Yosuke Kunitomi, Erika Yaguchi, Tomonori Hasegawa, Wataru Kotani, Rei Wada, Saki Tamegaya, Chonji Fukumoto, Takahiro Wakui, Hitoshi Kawamata

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: oral lichen planus; Stephania cephalantha Hayata; cepharanthine; IL-1β ; NF-κ B

Online: 14 August 2024 (08:20:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0041.v1

Fairness Oriented Neighbor-Channel-Aware MAC Protocol for Airborne Sensor Networks

Xiaolin Gao, Jian Yan, Jianhua Lu

Subject: Engineering, Electrical And Electronic Engineering Keywords: airborne sensor networks; media access control; fairness; neighbor-channel-aware; back-off

Online: 7 March 2017 (18:06:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0684.v1

Ad-Hoc Mesh Network Localization using Ultra-Wideband for Mobile Robotics

Marius F. R. Juston, William R. Norris

Subject: Engineering, Control And Systems Engineering Keywords: ultra-wideband; unscented Kalman filter; Ad-Hoc localization

Online: 9 January 2024 (10:15:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0210.v1

Two Dark Clouds on the Space-Time Horizon

TEJINDER P. SINGH

Subject: Physical Sciences, Particle And Field Physics Keywords: Gravitation; wide binaries; Modified Newonian Dynamics; dark matter; supraquantum nonlocal correlations; Bell's inequalities; CHSH inequality; fifth force; unification; quantum nonlocality; Popescu-Rohrlich bound

Online: 4 April 2024 (02:30:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1305.v1

Therapeutic Architecture Illumination And Environments Within Healing Space.

Hana Rasheed

Subject: Engineering, Architecture, Building And Construction Keywords: Mental Health; Half Way Home; Therapeutic Architecture; Biophonic Design; Lighting; Colour Therapy

Online: 23 February 2024 (08:27:08 CET)

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Mental healthcare conditions in India are severely deficient, particularly concerning the living conditions of patients. Post-treatment, numerous individuals with mental illness are abandoned by their families, who may lack the willingness or financial means to care for them. These recovered patients often experience setbacks due to the absence of facilities aimed at developing the skills necessary for reintegrating into society. The lack of separate accommodations for recovered individuals forces them to reside with other patients, worsening their condition. The government is struggling to accommodate and finance the care of recovered patients, affecting those in need of treatment as hospital bed space becomes overwhelmed by the increasing number of cured individuals. Therefore, there is an urgent need for halfway homes. These facilities offer a range of services, including social, medical, psychological, and educational support, alongside housing. The term "halfway houses" reflects their position between fully independent living and highly regulated in-patient or correctional facilities. Following treatment, many patients experience abandonment by their families or encounter difficulties returning home due to memory loss. Recovered patients often live in confined spaces, lacking essential social skills. Therefore, establishing a workspace focused on teaching social and other necessary skills before reintegrating them into society would be a beneficial approach. This would provide a structured environment for individuals who have spent significant time in seclusion, assisting them in developing the skills needed to navigate societal challenges effectively. Recent reports indicate that over 2,000 cured patients are still housed in mental hospitals across the country, according to the NHRC. The NHRC has raised concerns about the situation, noting that all 46 Government Mental Healthcare Institutions in India display very poor and inhumane treatment of patients, leading to the issuance of notices. NHRC visits have revealed deplorable conditions in all 46 mental institutes across the country.

Preprint REVIEW | doi:10.20944/preprints202402.1154.v1

3D Printing Modules for Self-Assembling Space Systems

Alex Ellery, Abdurr Elaskri

Subject: Engineering, Aerospace Engineering Keywords: additive manufacturing; 3D printed electric motors; self-assembly; reconfigurable robotics; flat-pack space structures; space debris resources

Online: 20 February 2024 (14:25:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0913.v1

The Electric Charge Influence on Space-Time Curvature

Eran Magshim Lavi

Subject: Physical Sciences, Theoretical Physics Keywords: electric charge; spacetime curvature; relativity

Online: 19 February 2024 (10:16:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0679.v2

Elliptical Space as the Possible Origin of Matter

Vladimir N. Yershov

Subject: Physical Sciences, Particle And Field Physics Keywords: elliptical space; de Sitter metric; Schwartzschild metric; wormholes; gravitational redshift; type-Ia supernovae

Online: 25 December 2023 (13:21:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1969.v1

Space Robot Sensor Noise Amelioration Using Trajectory Shaping

Emily Kuck, Timothy Sands

Subject: Engineering, Mechanical Engineering Keywords: analytic dynamics; celestial mechanics; stability, control, and synchronization; structural dynamics; equations of motion; finite element method; flexible robotics; bandpass filter; notch filter; structural filtering; trajectory generation; whiplash compensation

Online: 30 November 2023 (10:56:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0964.v1

Fuzzy Transform Image Compression in the YUV Space

Barbara Cardone, Ferdinando Di Martino, Salvatore Sessa

Subject: Computer Science And Mathematics, Computer Science Keywords: F-transform; F1-transform; color image compression; RGB space; YUV space.

Online: 14 September 2023 (09:08:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1058.v1

A Micro-Nuclear Power Generator for Space Missions

Olukayode L. Ayodele, Doudou N. Luta, Mohammed T. Kahn

Subject: Engineering, Energy And Fuel Technology Keywords: RTG; MMRTG; Li-ion battery, spacecraft; energy storage

Online: 27 April 2023 (07:51:43 CEST)

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The increased interest in space activities, structural health monitoring, and terrestrial monitoring in hostile and inaccessible zones places a high demand for energy sources for autonomous systems. Conventional electrochemical batteries that could be used are plagued by low energy storage density, short life, disposal of unwanted batteries, and related undesired recharging or replacement maintenance requirements, which endangers the environment. Fuel cells and solar energy sources being exploited to mitigate the adverse effect of environmental threats posed by batteries and fossil fuels are costly to acquire and maintain. The availability of energy sources derived from waste heat from radioactive decay for domestic appliances and industrial equipment will also help alleviate the effects of climate change, which continues to threaten the environment due to fossil fuel energy-based sources that emit harmful carbon monoxide into the atmosphere. A combination of energy from waste heat, harvested via thermoelectricity and existing battery technology to produce a hybrid energy source, can guarantee secured energy for an extended period. Based on the Seebeck effect, thermoelectric energy generation may considerably contribute to sustainable energy development and meet the power demand for spacecraft applications. Modeling of the energy from waste heat, the Li-ion battery, and a hybrid energy source are considered, and their performances are established using the MATLAB/Simulink environment. Results confirmed the comparative advantage of the hybrid energy source over and above the respective electrochemical batteries and waste heat energy sources regarding effectiveness and performance efficiency. Since batteries are required to operate in a constantly changing environment, the effects of temperatures on batteries were investigated. The results show that the performances of batteries decrease with a decrease in ambient temperature and that the higher the maximum operating capacity, the higher the battery's internal temperature.

Preprint ARTICLE | doi:10.20944/preprints202102.0162.v1

Discreteness of Space from Anisotropic Spin-Orbit Interaction

Barun Majumder, Ahmed Farag Ali

Subject: Physical Sciences, Mathematical Physics Keywords: space quantization; Planck length; discreteness of space

Online: 5 February 2021 (13:52:16 CET)

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Preprint REVIEW | doi:10.20944/preprints202101.0171.v1

Immunity in Space: Is Microgravity Friend or Foe?

Macauley J Green, Jonathan W Aylott, Paul Williams, Amir M Ghaemmaghami, Philip M Williams

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: microgravity; spaceflight; immunology; pathogens; macrophages; bacteria; viruses; innate immune response; adaptive immune response

Online: 11 January 2021 (09:44:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0460.v1

Superfluid Quantum Space as the Unified Field Theory

Srečko Šorli

Subject: Physical Sciences, Acoustics Keywords: unified field model; superfluid quantum space (SQS); gravity; entanglement; time

Online: 17 November 2020 (15:56:31 CET)

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Preprint ESSAY | doi:10.20944/preprints202005.0320.v1

Huge Filaments as Regions of Space-Time Deformation

Irina Rozgacheva

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: cosmology; large scale structure; huge filaments; space-time deformation

Online: 20 May 2020 (06:52:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0368.v4

C⁴ Space-Time.. A Window to New Physics?

Dimitris Mastoridis, Konstantinos Kalogirou

Subject: Physical Sciences, Mathematical Physics Keywords: extended space-time; complex space-time; unified theories; geometric unification; dark matter-energy; Cartan's principle of triality; extended general-special relativity

Online: 7 February 2020 (04:34:13 CET)

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We explore the possibility to form a physical theory in $C^4$. We argue that the expansion of our usual 4-d real space-time to a 4-d complex space-time, can serve us to describe geometrically electromagnetism and nuclear fields and unify it with gravity, in a different way that Kaluza-Klein theories do. Specifically, the electromagnetic field $A_\mu$, is included in the free geodesic equation of $C^4$. By embedding our usual 4-d real space-time in the symplectic 8-d real space-time (symplectic $R^8$ is algebraically isomorphic to $C^4$), we derive the usual geodesic equation of a charged particle in gravitational field, plus new information which is interpreted. Afterwards, we formulate and explore the extended special relativity and extended general relativity an $C^4$ or$R^8$. After embedding our usual 4-d space-time in $R^8$, two new phenomena rise naturally, that are interpreted as "dark matter" and "dark energy". A new cosmological model is presented, while the geometrical terms associated with "dark matter" and "dark energy" are investigated. Similarities, patterns and differences between "dark matter", "dark energy", ordinary matter and radiation are presented, where "dark energy" is a dynamic entity and "dark matter" reveal itself as a "mediator" betwen ordinary matter and "dark energy". Moreover, "dark matter" is deeply connected with "dark energy". Furthermore, the extended Hamilton-Jacobi equation of the extended space-time, is transformed naturally as an extended Klein-Gordon equation, in order to get in contact with quantum theories. By solving the Klein-Gordon equation analytically, we derive an eigenvalue for Higg's boson mass value at 125,173945 $Gev/c^{2}$. The extended Klein-Gordon equation, also connects Higg's boson (or vacuum) with Cosmology, due to the existence of our second "time" T (cosmological time), which serve us to connect quantum theories with Cosmology. Afterwards, in the general case, we explore the symmetries of the curved Hamilton-Jacobi equation locally, in order to investigate the consequences of a $C^4$ space-time in Standard Model. An extension to Standard Model is revealed, especially in the sector of strong nuclear field. The Stiefel manifold $SU(4)/SU(2)$ seems capable not only to describe the strong nuclear field but give us,as well, enough room to explore in the future, the possibility to explain quark confinment. Our extension, flavors firstly the unification of nuclear fields and afterwards the unification of nuclear fields with electromagnetic field. The desired grand unification, is achieved locally, through the symmetry group $GL(4,C)\simeq SO(4,4)\cap U(4)$ and we present a potential mechanism to reduce the existing particle numbers to just six. Afterwards,23 present the extended Dirac equation in $C^4$ space-time (Majorana-Weyl representation) plus a preliminary attempt to introduce a pure geometric structure for fermions. Finally, we consider a new geometric structure through n-linear forms in order to give geometric explanation for quantisation

Working Paper ARTICLE

On a Duality between Time and Space Cones

Waleed Al-qallaf, Kyriakos Papadopoulos

Subject: Computer Science And Mathematics, Geometry And Topology Keywords: causality; chronology; chorology; Minkowski space; time cone; space cone; weak interval topology; duality

Online: 24 May 2019 (08:22:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0374.v1

Introduction to Fermionic Structures in C⁴ Space-Time

Dimitris Mastoridis, K. Kalogirou

Subject: Physical Sciences, Space Science Keywords: unied theories; geometric unication; fermionic geometry; Cartan's principle of triality; complex space-time

Online: 19 September 2018 (08:34:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0291.v1

The Design of Space Based on Architectural Geometry

Wasilah Wasilah, Andi Hildayanti, Hamzah Hamzah

Subject: Engineering, Energy And Fuel Technology Keywords: expressional space; geometry architecture; mural; skateboard; landscape; pure geometry; composition of geometry; direction wall; opening; space form

Online: 23 April 2018 (12:03:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0125.v1

A General State-Space Formulation for Online Scheduling

Dhruv Gupta, Christos T. Maravelias

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: state-space model; uncertainty; mixed-integer linear programming; model predictive control; bio-manufacturing

Online: 18 October 2017 (03:56:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201610.0129.v1

Space-Time Characterization of Rainfall Field in Tuscany

Alessandro Mazza

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: rainfall; rain gauge; kriging; trend detection

Online: 31 October 2016 (01:37:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.1946.v1

Investigation of the Main Operational Properties of Polymer-Based Composites with the Content of Modified Mineral Filler

Ruslan E. E. Nurlybayev, Erzhan I. Kuldeyev, Erzhan I. Kuldeyev, Zhanar O. Zhumadilova, Axaya S. Yestemessova, Yelzhan S. Orynbekov

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: acrylate binder; modified filler; adhesion; coatings; covering; porosity

Online: 27 June 2024 (16:46:04 CEST)

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The article presents the results of research work devoted to the study of composite materials on polymer binder with the content of modified mineral filler - water-dispersion paint and varnish materials on acrylic polymer with modified filler - diatomite. The aim of the study is to obtain polymer-based composites with modified diatomite (water-dispersion paint on acrylic binder) with improved performance properties. Methods: determination of porosity, adhesion, elasticity, hiding power of the control composition; determination of porosity, adhesion, elasticity, hiding power of the obtained composites with the use of modified filler; investigation of the influence of radiation in the infrared radiation (IR) region of the spectrum of the paint coating surface using FLIRB620 thermal imager. As a result of work it is noticed that modification of water dispersions by silica activated diatomite promotes elimination of the main disadvantages of materials and coatings on the basis of acrylate binder - low water resistance and low physical and mechanical characteristics, introduction of modified diatomite into water emulsion paint on acrylate basis does not lead to deterioration of the main operational characteristics of paint and varnish coatings - porosity, adhesion, elasticity and covering. When analyzing the effect of emissivity in the IR region of the spectrum of the paint coating surface, a significant effect of the quantitative content of modified diatomite on the reduction of emissivity of paint coatings in the IR region of the spectrum was established and it was shown that a significant effect of the reduction of emissivity of paint coatings in the IR region of the spectrum is provided by the introduction of modified diatomite in the amount of 40 wt.h. into the mixture. The influence of the time of full-scale tests in the investigated small range regardless of the quantitative composition of modified diatomite on the performance characteristics of the paintwork was established.

Preprint ARTICLE | doi:10.20944/preprints202405.1500.v1

Identification of Anastatica hierochuntica L. Methanolic Leaves Extract-Derived Metabolites Exhibiting Xanthine Oxidase Inhibitory Activities: In Vitro and in Silico Approaches

Saranya Rameshbabu, Zeyad Alehaideb, Sahar S Alghamdi, Rasha S Suliman, Feras Almourfi, Syed Ali Mohamed Yacoob, Anuradha Venkataraman, Safia Messaoudi, Sabine Matou-Nasri

Subject: Biology And Life Sciences, Life Sciences Keywords: Anastatica hierochuntica; chemical composition; metabolites; metabolic enzyme inhibitor; xanthine oxidase

Online: 23 May 2024 (10:53:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0705.v1

Assessing Digestate at Different Stabilization Stages: Application of Thermal Analysis and FTIR Spectroscopy

Silvia González-Rojo, Daniela Carrillo-Peña, Ruben González, Xiomar Gómez

Subject: Engineering, Chemical Engineering Keywords: anaerobic stabilization; thermal valorization; mineralization; activation energy

Online: 13 May 2024 (02:53:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0417.v1

Tadalafil for Treatment of Fetal Growth Restriction: A Review of Experimental and Clinical Studies

Shintaro Maki, Sho Takakura, Makoto Tsuji, Shoichi Magawa, Yuya Tamaishi, Masafumi Nii, Michiko Kaneda, Kenta Yoshida, Kuniaki Toriyabe, Eiji Kondo, Tomoaki Ikeda

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: Phosphodiesterase 5 inhibitor; Tadalafil; Fetal growth restriction

Online: 7 March 2024 (11:10:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0864.v1

Nanostructured PR-Rich Ce_xPr_1-xO_2-δ Mixed Oxides for Diesel Soot Combustion. Importance of Oxygen Lability.

Imene Mekki, Gabriela Grzybek, Andrzej Kotarba, Avelina García-García

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: ceria-praseodymia nanoparticles; diesel soot combustion; catalytic activity; oxygen vacancies

Online: 15 February 2024 (15:47:17 CET)

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Soot combustion experiments with 5%O2/He were conducted using model soot, and four distinct compositions of CexPr1-xO2-δ oxides were prepared, varying nominal cerium com-positions (x=0, 0.2, 0.3, and 1). The catalyst samples were comprehensively characterized using techniques such as XRD, Raman spectroscopy, HR-TEM, N2 adsorption at −196 °C, XPS, O2-TPD, H2-TPR, and work function measurements. The Pr-rich compositions, rang-ing from Ce0.3Pr0.7O2-δ to PrO2-δ, resulted in a significant increase in the total evolved O2 amounts and enhanced catalyst reducibility. However, a decrease in textural properties of the catalysts was noted, being particularly important for the pure praseodymia under the synthesis route conducted. The catalytic activity was investigated under two contact modes of mixing between soot and catalyst: loose and tight. The results revealed that the catalytic performance is associated with the surface contact in tight contact mode and with the combination of surface/subsurface/bulk oxygen mobility and the BET surface ar-ea in loose contact mode. Notably, the T10 and T50 parameters were achieved at much lower temperatures than the uncatalyzed soot combustion, even under loose contact conditions. Specifically, the 50% conversion was achieved at 511℃ and 538℃ for Ce0.3Pr0.7O2 and Ce0.2Pr0.8O2, respectively. While no direct correlation between catalytic activity and work function was observed a significant relationship emerges between work function values and the formation of oxy-gen vacancies, whatever the conditions used for these measurements. On the other hand, the ability to generate a high population of oxygen vacancies at low temperatures, rather than the direct activation of gas-phase O2, influences the catalytic performance of Pr-doped ceria catalysts, highlighting the importance of surface/subsurface oxygen vacancy generation, which was the parameter which showed better correlation with the catalytic activity, whatever the soot conversion value or the mode of contact considered.

Preprint ARTICLE | doi:10.20944/preprints202311.1688.v1

Title Impact of Exogenous Lactobacillus plantarum on the Gut Microbiome of Hematopoietic Stem Cell Transplantation Patients Colonized by Multi-Drug Resistant Bacteria

Bruna D.G.C. Moraes, Roberta CR Martins, Joyce Vanessa da Silva Fonseca, Lucas AM Franco, Gaspar CO Pereira, Thaisi F Bartelli, Marina F Cortes, Carolina F Santos, Priscila T Musqueira, Leonardo J Otuyama, Victor S. Pylro, Livia Mariano, Vanderson Rocha, Steven S Witkin, Ester C Sabino, Thais Guimaraes, Silvia F Costa

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: L. plantarum; Microbiome, MDRO colonization

Online: 27 November 2023 (11:32:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0273.v1

Integrated into Environmental Biofilm Chromobacterium Vaccinii Survives Winter with Support of Bacterial Community

Daria A. Egorova, Olga L. Voronina, Andrey I. Solovyev, Marina S. Kunda, Ekaterina I. Aksenova, Natalia N. Ryzhova, Ksenya V. Danilova, Valentina S. Rykova, Anastasya A. Scherbakova, Andrey N. Semenov, Nikita B. Polyakov, Daniil A. Grumov, Natalia V. Shevlyagina, Inna V. Dolzhikova, Yulia M. Romanova, Alexander L. Gintsburg

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Chromobacterium vaccinii; biofilm; sharing goods; social cheater; bog microbiome; bacterial genome, violacein, cold adaptation, IDBac, QS mutant

Online: 12 September 2020 (12:04:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201612.0090.v1

Fundamentals of the Behavior of Concrete Recycled with PET Additives through Its Porosity

J. Miguel Mendivil-Escalante, J. Manuel Gómez-Soberón, J. Luis Almaral-Sánchez, F. Guadalupe Cabrera-Covarrubias

Subject: Engineering, Civil Engineering Keywords: PET additives; recycled concrete; concrete porosity; polymeric resins; porosimetry of nitrogen (N2) gas adsorption; acoustic resonance spectroscopy

Online: 16 December 2016 (11:01:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.2001.v1

Amphiphilic Fluorescein Triazoles: Synthesis and Visible Light Catalysis in Water

Alina Artemenko, Elza Sultanova, Diana Mironova, Aliya E. Akhatova, Ekaterina Bondareva, Daut R. Islamov, Konstantin Usachev, Svetlana E. Solovieva, Vladimir Burilov, Igor S. Antipin

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: CuAAC; photocatalysis; fluorescein derivatives; aggregation

Online: 25 July 2024 (09:25:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.0106.v1

Comprehensive Review on the Impact of Chemical Composition, Plasma Treatment, and Vacuum Ultraviolet (VUV) Irradiation on the Electrical Properties of Organosilicate Films

Mikhail R. Baklanov, Andrei A. Gismatulin, Sergej Naumov, Timofey V. Perevalov, Vladimir A. Gritsenko, Alexey S. Vishnevskiy, Tatyana V. Rakhimova, Konstantin A. Vorotilov

Subject: Physical Sciences, Condensed Matter Physics Keywords: organosilicate glass (OSG); low-k dielectrics; thin film; electrical properties degradation; charge transport; trap energy; chemical composition; bonding configuration; density functional theory (DFT); photoluminescence

Online: 1 July 2024 (12:59:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1717.v1

Retrospective Review of Positive Newborn Screening Results for Isovaleric Acidemia and Development of a Strategy to Improve the Efficacy of Newborn Screening in the UK.

Rachel S Carling, Katy Hedgethorne, Anupam Chakrapani, Patricia L Hall, Nick Flynn, Toby Greenfield, Stuart J. Moat, Joshua Ssali, Lynette Shakespeare, Nazia Taj, Mark Anderson, Teresa H.Y. Wu, Arunabha Ghosh, Hugh Lemonde, Germaine Pierre, Mark Sharrard, Sreevidya Sreekantam, James R Bonham

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: isovaleric acidemia; false positive; newborn screening; inherited metabolic disease.

Online: 24 January 2024 (09:54:13 CET)

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Preprint REVIEW | doi:10.20944/preprints201708.0076.v1

30 Years of Research on Crown-of-thorns Starfish (1986-2016): Scientific Advances and Emerging Opportunities

Morgan S. Pratchett, Ciemon F. Caballes, Jennifer C. Wilmes, Samuel Matthews, Camille Mellin, Hugh P.A. Sweatman, Lauren E. Nadler, Jon Brodie, Cassandra A. Thompson, Jessica Hoey, Arthur R. Bos, Maria Byrne, Vanessa Messmer, Sofia Valero-Fortunato, Carla C.M. Chen, Alexander C.E. Buck, Russell C. Babcock, Sven Uthicke

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Acanthaster; coral reefs, disturbance; management; population outbreaks; research priorities

Online: 22 August 2017 (10:20:00 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202001.0176.v1

Beyond Modeling: A Roadmap to Community Cyberinfrastructure for Ecological Data-Model Integration

Istem Fer, Anthony K. Gardella, Alexey N. Shiklomanov, Shawn P. Serbin, Martin G. De Kauwe, Ann Raiho, Miriam R. Johnston, Ankur Desai, Toni Viskari, Tristan Quaife, David S. LeBauer, Elizabeth M. Cowdery, Rob Kooper, Joshua B. Fisher, Benjamin Poulter, Matthew J. Duveneck, Forrest M. Hoffman, William Parton, Joshua Mantooth, Eleanor E. Campbell, Katherine D. Haynes, Kevin Schaefer, Kevin R. Wilcox, Michael C. Dietze

Subject: Computer Science And Mathematics, Computer Science Keywords: community cyberinfrastructure; accessibility; reproducibility; interoperability; models

Online: 17 January 2020 (04:28:34 CET)

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Preprint REVIEW | doi:10.20944/preprints202408.0461.v1

Tailoring Semantic Interventions for the Elderly: Task-Focused vs Person-Centered Approaches

Vasiliki Folia, Susana Silva

Subject: Social Sciences, Language And Linguistics Keywords: linguistic semantic interventions; cognitive intervention programs; person-centered approach; task-focused approach; elderly

Online: 7 August 2024 (00:35:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0373.v1

Protecting the High Seas from Illegal, Unregulated, and Unreported Fishing with Overarching Management

Laura Nieminen, Mark Tupper, Ian Hendy

Subject: Biology And Life Sciences, Aquatic Science Keywords: high seas; illegal fishing; marine resource management; marine protected areas; subsidies; sustainable fisheries

Online: 4 April 2024 (11:02:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202402.0590.v1

Towards the Exploration and Evolution of Insulin-Derived Venoms in Actiniaria (Sea anemones)

Alonso Delgado, Kyle S Sozanski, Marymegan Daly

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Insulin-like peptides; Cono-toxins; Venom; Venomics; Toxins; Transcriptome; Sea anemone; Selection; Actinaria; Cnidaria

Online: 9 February 2024 (14:03:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0214.v1

Chromosome-Level Assemblies for the Pine Pitch Canker Pathogen Fusarium circinatum

Lieschen De Vos, Magriet A Van der Nest, Quentin C Santana, Stephanie Van Wyk, Kyle S. Leeuwendaal, Brenda D Wingfield, Emma T Steenkamp

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: dispensable chromosome; centromere; telomere; intrachromosomal translocation

Online: 5 December 2023 (04:33:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1236.v1

Dissecting the Impact of USP21 on Mouse Lipid Metabolism and Identifying Polymorphism-Associated Hypercholesterolemia in Outpatients

Sailakshmi Iyer, Naoko Hattori, Hiroshi Okuda, Takeya Nakagawa, Takahiro Maeda, Haruhiko Koseki, Takashi Ito

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: USP21; Fabp7; Nlrc5; hypercholesterolemia

Online: 20 November 2023 (09:29:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0500.v1

Nanostructural Characterization of Luminescent Polyvinyl Alcohol / Graphene Quantum Dots Nanocomposite Films

Dhanumalayan Elumalai, B. Rodríguez, G. Kovtun, P. Hidalgo, B. Méndez, S. Kalleemula, G. M. Joshi, M. T. Cuberes

Subject: Chemistry And Materials Science, Nanotechnology Keywords: Polyvinyl Alcohol; Graphene Quantum Dots; Atomic Force Microscopy; Ultrasonic Force Mi-croscopy; Friction Force Microscopy; Photoluminescence; X-Ray Difraction; Infrared Spectroscopy; Thermogravimetry; Differential Thermal Analysis

Online: 8 November 2023 (07:37:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1656.v1

Clinical Outcomes of Next-Generation Microwave Thermosphere Ablation for Hepatocellular Carcinoma with Primarily Hepatitis-Related Etiology

Shinichiro Nakamura, Toshifumi Tada, Masahiko Sue, Yu Matsuo, Shiho Murakami, Toshiro Muramatsu, Kazuhiko Morii, Hiroyuki Okada

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: microwave thermosphere ablation; hepatocellular carcinoma; recurrence; safety

Online: 26 October 2023 (03:59:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0488.v1

Gamow–Teller Beta Decay and Pseudo-SU(4) Symmetry

P. Van Isacker, A. Algora, A. Vitéz-Sveiczer, G. G. Kiss, S. E. A. Orrigo, B. Rubio, P. Aguilera Pablo Antonio Aguilera Jorquera

Subject: Physical Sciences, Nuclear And High Energy Physics Keywords: Gamow–Teller b decay; pseudo-SU(4) symmetry; odd–odd N = Z nuclei

Online: 9 October 2023 (11:40:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0455.v1

Internal Rotation Measurement of the Knee Joint with Capacitive Strain Gauges Compared to Conventional Mechanical Rotation Measurement

Hermann O. Mayr, Nikolaus Rosenstiel, Karthika S. Prakash, Laura Maria Comella, Peter Woias, Hagen Schmal, Michael Seidenstuecker

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: laxitx measuremenrt knee; straingauges; anterolateral ligament knee; elastic capacitive measuring system

Online: 9 October 2023 (04:34:47 CEST)

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Introduction and Problem: With conventional mechanical rotation measurement of joints, only static measurements are possible with the patient at rest. In the future, however, it would be interesting to carry out dynamic rotation measurements, for example when walking or doing sports. Therefore, a measurement method with an elastic capacitive measuring system was developed and validated. Material and Methods: The measurement system consists of a capacitive strain gauge connected to a flexible printed circuit board. The electronics on the printed circuit board are used for data acquisition and transmission. When the sensor strip is stretched, the distance between the fingers of the strain gauge changes and with it the capacitance. Consequently, the strain can be measured via the change in capacitance. The measurement system is taped to the knee with the sensor on the skin in the direction of the anterolateral ligament (ALL). The bottom of the sensor (silicone) and the bottom of the circuit board are in contact with the knee surface. The sensor must be attached to the knee without pre-stretching The system is validated with an in vivo test on 11 patients. For this purpose, the internal rotational laxity of the knee was tested on healthy volunteers and the results compared with the measurements on the static measuring device (Laxitester). The subjects are placed in the supine position. First the left and then the right leg is clinically examined one after the other and documented using an examination form. Exclusion criteria are the presence of a pathological ligament findings in the area of the collateral/cruciate ligaments, previous knee operations or limitations in the range of motion. The distal thigh rests on a support bench on which a knee joint flexion of 30° is set by height adjustment. The femoral condyles are secured against rotation in the positioning aid by posts. This also prevents internal rotation and displacement of the thigh. The foot is strapped into the holding device without shoes. The second toe beam is centered using an adjustable side clamp on the medial and lateral edge of the foot. Dorsiflexion is set at 2 Nm with a torque meter, in accordance with previous studies, to rule out rotational laxity in the ankle. The strain gauge sensor is taped to Gerdii’s tubercle in the course of the antero-lateral ligament below the lateral epicondyle of the thigh. Then, in three repeated measurements, the internal rotation of the foot and thus the lower leg is measured with a torque of 2 Nm. The change in length of the stretch mark is compared with the measured internal rotation angle in the static measuring device (Laxitester). Results: A significant difference between the sexes was found in the internal rotation range of the knee (p=0.003). The range of rotation was greater for female participants than for male participants. Regarding the measured length change values, the measurements presented showed an individual result for each participant, which tended to decrease with increasing internal rotation angle, with no age or gender differences being observed. The stiffness of the strain gauge was in the linear range for all measurements, within the first 20% strain of the sensor. The differences determined do not result from a different stretching of the sensor, but from individual differences between the test persons. The comparison between length change and internal rotation angle of the knee showed a strong positive correlation (r=1, p<0.01). Conclusion: Elastic capacitive strain gauges can be used to reliably measure the internal rotation angle of the knee joint. This will allow dynamic measurements in the future.

Preprint ARTICLE | doi:10.20944/preprints202310.0269.v1

Echocardiographic Changes in Saudi Patients with Type 2 Diabetes Mellitus

Turky H. Almigbal, Dina S. Almunif, Khaled H. Aburisheh, Mazen M. Barhoush, Reem A. Aldhahi, Mohammed Jamal Anabi, Obeed A. Alotaibi

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Diabetes mellitus; diabetes cardiomyopathy; echocardiography

Online: 5 October 2023 (10:57:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0702.v1

Febrile Seizures Cause a Rapid Depletion of Calcium-Permeable AMPA Receptors at the Synapses of Principal Neurons in the Entorhinal Cortex and Hippocampus of the Rat

Tatyana Y. Postnikova, Alexandra V. Griflyuk, Arseniy S. Zhigulin, Elena B. Soboleva, Oleg I. Barygin, Dmitry V. Amakhin, Aleksey V. Zaitsev

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: febrile seizures; hyperthermia; hippocampus; GluA2-lacking AMPA receptor; entorhinal cortex; IEM-1460; development

Online: 11 July 2023 (10:19:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0218.v1

Interaction of Hoechst 33342 with Lipid Membranes at Different pH Values

Margarida M. Cordeiro, Hugo A. L. Filipe, Patrícia dos Santos, Jaime Samelo, João P. Prates Ramalho, Luís M. S. Loura, Maria J. Moreno

Subject: Biology And Life Sciences, Biophysics Keywords: biomembranes; cationic amphiphiles; fluorescent probe; membrane partition; molecular dynamics simulations; POPC

Online: 4 July 2023 (11:44:18 CEST)

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Hoechst 33342 (H33342) is a fluorescent probe that is commonly used to stain DNA of living cells. To do so, it needs to interact with and permeate through cell membranes. The pH of biological media may vary quite significantly and this influences H33342 ionization state, and may change its rate of permeation through biomembranes. In this work, we address the effect of pH in the association of H33342 with lipid bilayers using a combined experimental and computational approach. The partition of H33342 to 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) lipid membranes was experimentally quantified using fluorescence spectroscopy and isothermal titration calorimetry (ITC) measurements. Quantum chemical calculations were performed to select the most stable isomer of H33342 for the overall charges 0, +1, and +2, expected to predominate across the 5 < pH < 10 range. The interaction of these isomers with POPC bilayers was then studied by both unrestrained and umbrella sampling molecular dynamics simulations. While probe insertion occurs for all ionization states, with similar overall equilibrium location, orientation was found to depend on the probe charge, with the neutral form lying mostly parallel and the doubly charged displaying a significant tilt relative to the membrane plane. Both experimental results and computational free energy profiles indicate that the partition coefficient of H33342 displays a small variation over a wide pH range, not exceeding one order of magnitude. The enthalpy of interaction is negative and is larger at lower pH values. This suggests efficient hydrogen bonding between the probe and the lipid, namely for the protonated +2 form. The relatively high lipophilicity obtained for the charged species contrasts with the decrease in their general hydrophobicity as estimated from water and octanol partition. This highlights the distinction between lipophilicity and hydrophobicity, and the importance of considering association with lipid bilayers when predicting the affinity for biomembranes.

Preprint ARTICLE | doi:10.20944/preprints202306.0257.v1

Ciprofloxacin-Loaded Polyvinylpyrrolidone Foils for the Topical Treatment of Wound Infections with Methicillin-Resistant Staphylococcus aureus (MRSA)

Fiorenza Rancan, Jana Jurisch, Sabrina Hadam, Annika Vogt, Ulrike Blume-Peytavi, Ilker S. Bayer, Marco Contardi, Christoph Schaudinn

Subject: Medicine And Pharmacology, Dermatology Keywords: wound dressing; drug delivery; organ culture, infection models, ciprofloxacin, infected wounds

Online: 5 June 2023 (08:09:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1011.v1

Prevalence of Vitamin B₁₂ and Folate Deficiencies in Indian Children and Adolescents

Tattari Shalini, Raghu Pullakhandam, Santu Ghosh, Bharati Kulkarni, Hemalatha Rajkumar, Harshpal S Sachdev, Anura V Kurpad, Geereddy Bhanuprakash Reddy

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Vitamin B12 deficiency; Folate deficiency; School-age children; Adolescents; CNNS

Online: 15 May 2023 (09:45:12 CEST)

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Deficiencies of vitamin B12 (B12) and folate (FA) are of particular interest due to their pleiotropic role in 1-carbon metabolism. In addition to adverse birth outcomes, deficiencies of B12 and FA, or an imbalance in FA/B12 status, are linked to metabolic disorders. Indian diets that are predominantly plant food-based could be deficient in these vitamins, but there are no national estimates of the prevalence of B12 and FA deficiency in Indian children and adolescents, nor of their associations with age, sex, and growth indicators. The recent Comprehensive National Nutrition Survey (CNNS-2016-18) provided estimates of the prevalence of B12 and FA deficiency at the national and state level among preschool (1-4y: 9,976 and 11,004 children respectively), school-age children (5-9y: 12,156 and 14,125) and adolescents (10-19y: 11,748 and 13,621). Serum B12 and erythrocyte FA were measured by the direct chemiluminescence method and their deficiency was defined using WHO cut-offs. The prevalence of B12 and FA deficiency was high among adolescents (31.0%, CI: 28.7-33.5 and 35.6%, CI: 33.1-8.2), compared to school-age (17.3%, CI: 15.4-19.3 and 27.6%, CI: 25.5-29.9) and preschool children (13.8%, CI: 11.7-16.2 and 22.8%, CI: 20.5-25.2, respectively). The prevalence of both B12 and FA deficiency was significantly higher by 8 and 5% points respectively, in adolescent boys compared to girls. The prevalence of B12 deficiency was higher in moderately stunted school children (by 18.9% points) than in normal children, but no such difference was observed for FA deficiency. There was wide regional variation in the prevalence of B12 and FA deficiency, but no rural-urban differences were observed across all age groups. The national prevalence of B12 deficiency among preschool or school-age children was <20% (the cut-off that indicates a public health problem). However, FA deficiency in these age groups and both FA and B12 deficiencies in adolescents were >20%, which warrants further investigation.

Preprint ARTICLE | doi:10.20944/preprints202304.1123.v1

Optimized FACTS Devices for Power System Enhancement: Applications and Solving Methods

Ismail Marouani, Tawfik Guesmi, Badr M. Alshammari, Khalid Alqunun, Ahmed S. Alshammari, Saleh Albadran, Hsan Hadj Abdallah, Salem Rahmani

Subject: Engineering, Electrical And Electronic Engineering Keywords: FACTS devices; FACTS optimization problem; conventional optimization techniques; Meta heuristic methods; sensitive index methods; mixed methods

Online: 28 April 2023 (05:32:12 CEST)

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Using flexible AC transmission system (FACTS) devices in power systems while adhering to some equality and inequality constraints, researchers around the world sought to address this issue with the objectives of improving the voltage profile, reducing power losses in transmission lines, and increasing system reliability and safety. The recent development of FACTS controllers opens up new perspectives for safer and more efficient operation of electrical power networks by continuous and rapid action on power systems parameters, such as phase angle shifting, voltage injection and line impedance compensation. Thus, an improvement on voltage profile and enhancement of power transfer capability can be obtained. It is for that, the idea behind the FACTS concept is to enable the transmission system to be an active element in increasing the flexibility of power transfer requirements and in securing stability of integrated power system. It may also be effective in transient stability improvement, power oscillations damping and balancing power flow in parallel lines. The primary issue that has significantly piqued the interest of a number of researchers working in this field is the FACTS optimization problem, which involves determining the optimal type, location, and size of FACTS devices in electrical power systems. For solving this mixed integer, nonlinear and non-convex optimization problem, this paper provides an in-depth and comprehensive review of the various optimization techniques covered in published works in the field. In this review, a classification of optimization techniques in five main groups that are widely used, such as classical optimization techniques or conventional optimization approaches, Meta heuristic methods, analytic methods or sensitive index methods and mixed or hybrid methods, is summarized. In addition, a performance descriptions and comparison of these different optimization techniques are discussed in this study. Finally, some advice is offered for future research in this field.

Preprint ARTICLE | doi:10.20944/preprints202303.0430.v1

Impact of COVID-19 Infection on Cardiorespiratory Fitness, Sleep, and Psychology of Endurance Athletes– CAESAR Study

Daniel Śliż, Szczepan Wiecha, Jakub S. Gąsior, Przemysław Seweryn Kasiak, Katarzyna Ulaszewska, Marcin Lewandowski, Marcin Barylski, Artur Mamcarz

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: COVID-19; Endurance athletes; mental health; sleep; cardiopulmonary exercise testing; cardiorespiratory fitness; exercise capacity; physical exercise; psychology

Online: 24 March 2023 (12:23:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202303.0369.v1

Bacterial Contamination Levels and Brand Perception of Sachet Water: A Case Study in Nigerian Urban Neighborhoods

I. T. Tenebe, E. O. Babatunde, C. C. Eddy-Ugorji, N. B. Ogarekpe, C. V. Ekeanyanwu, O. S. Oladele, O. B. Ezendu

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: Sachet water; water quality; bacteriological quality; public health; drinking water

Online: 21 March 2023 (06:14:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0467.v1

Genetic Diversity of Cytochrome P450s CYP6M2 and CYP6P4 Associated with Pyrethroid Resistance in the Major Malaria Vectors Anopheles coluzzii and Anopheles gambiae from Yaoundé, Cameroon

Yvan Gaetan Fotso-Toguem, Billy Tene-Fossog, Leon M.J. Mugenzi, Murielle J. Wondji, Flobert Njiokou, Hilary Ranson, Charles S. Wondji

Subject: Biology And Life Sciences, Insect Science Keywords: CYP6M2; CYP6P4; polymorphism; metabolic resistance; pyrethroid; Anopheles coluzzii; Anopheles gambiae

Online: 25 November 2022 (05:51:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202208.0043.v1

Upregulation of Cytoglobin in 3D-cultures of Head and Neck Cancer Cells: Role of Hypoxia and Implications for Cisplatin Resistance

Garret Rochford, Rameeza Basar, Rose Dhiman, Djeren Simitdjioglu, Lorna S Thorne, Lakis Liloglou, Janet M. Risk, Nikolas J Hodges

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cytoglobin; spheroids; hypoxia; HIF1A; head and neck cancer

Online: 2 August 2022 (06:23:18 CEST)

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Cytoglobin has been implicated in a range of pathological conditions including fibrosis and cancer, where cytoglobin expression is linked to hypoxia- and drug-resistance. One disease where there is evidence of a role for cytoglobin is head and neck squamous cell carcinoma, a disease with a poor prognosis and where clinical resistance to platinum-based drugs is common. In the current study, we demonstrate that 3D-culture of head and neck cancer cells (PE/CA-PJ41, Liv-22K) and normal oral keratinocyte cells (NOK-hTERT) results in changes in sensitivity to cisplatin cytotoxicity compared to 2D-cultures. Relative to 2D-cultures, 3D-cultures of PE/CA-PJ41 and NOK-hTERT cells demonstrated increased cisplatin resistance. In contrast, 3D-cultures of Liv-22K cells were more sensitive to cisplatin. Evidence for cisplatin genotoxicity was observed in the form of GADD45A activation in PE/CA-PJ41 cells but not the other two cell types investigated. Furthermore, DNA-strand breaks were also detected by the alkaline comet assay in PE/CA-PJ41 cells although levels were not significantly affected by 3D-culture. Cytoglobin expression levels were elevated by 3D-culture in all three cell lines investigated and there were also changes in expression of genes related to cell division (MKI57, GJB6), cell adhesion (CDH1), stress response (NFkB, NQO1) and apoptosis (Casp3) but these changes were cell line specific. We also observed consistent transcriptional activation of HIF1a in 3D-cultures of all three cell lines, suggestive of hypoxic conditions in spheroids. In support of a direct role of hypoxia in cytoglobin induction, the HIF1a stabiliser cobalt chloride also induced cytoglobin expression in spheroids. Transcriptomic profiling of PE/CA-PJ41 cells over-expressing cytoglobin identified 121 differentially regulated genes, when cells were cultured under hypoxic conditions. Major changes identified included, upregulation of G1/S cell cycle regulation as well as wnt- and RhoGTPase-signalling pathways. In conclusion, 3D-cultures are a useful model to further study the biological function of cytoglobin in head and neck cancer and we provide evidence that further supports a role for cytoglobin in hypoxia-dependent cellular proliferation and phenotypic changes that could contribute to cisplatin resistance in vivo.

Preprint REVIEW | doi:10.20944/preprints202112.0447.v1

Cancer Immunotherapy Biomarkers of Response and Toxicity; Current Limitations and Future Promise

Brian Richard Healey Bird, Ken Nally, Karine Ronan, Gerard Clarke, Sylvie Amu, Anna S. Almeida, Richard Flavin, Stephen Finn

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer; immunotherapy; biomarker; microenvironment; microbiome; flow cytometry; cytokine

Online: 28 December 2021 (11:13:13 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202105.0679.v1

Mold Detection on Food Surfaces Using YOLOv5

Md. F. Jubayer, Md. J. A. Soeb, Mitun K. Paul, Pranta Barua, Md. S. Kayshar, Md. M. Rahman, Md. A. Islam

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: YOLOv5; object detection; mold; food spoilage; deep learning.

Online: 27 May 2021 (14:14:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0324.v1

Brain Morphology and Physical Symptoms: A Population-Neuroimaging Study in 13,250 Pre-Adolescents

Fernando Estévez-López, Hannah H. Kim, Mónica López-Vicente, Jeroen S. Legerstee, Manon H. J. Hillegers, Henning Tiemeier, Ryan Muetzel

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Cohort studies; Epidemiology; Gray matter; Neuroimaging; Paediatrics; Psychiatric symptoms; QDECR; Vertex-wise analysis.

Online: 14 May 2021 (11:31:23 CEST)

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Physical symptoms are defined as symptoms for which adequate examination does not reveal a sufficient underlying root cause, e.g., pain and fatigue. The extant literature of the neurobiological underpinnings of physical symptoms has been largely inconsistent and primarily consists of (clinical) case-control studies with relatively small samples sizes. Therefore, we studied the association of brain morphology with physical symptoms in pre-adolescents from two independent and population-based cohorts. This study included 2,683 individuals from the Generation R Study (51% girls, 10.1 ± 0.6 years old) and 10,567 pre-adolescents from the ABCD Study (48% girls, 9.9 ± 0.6 years old). High- resolution structural magnetic resonance imaging (MRI) was collected using 3-Tesla MRI systems. Physical symptoms were evaluated using the somatic complaints syndrome scale from the parent-reported school-age version of the Child Behavior Checklist. Linear regression models were fitted for global brain metrics (i.e., cortical and subcortical grey matter volume and total white matter volume) as well as surface-based vertex-wise measures (surface area and cortical thickness). Analyses were initially conducted separately in each cohort and later meta-analysed. No associations were observed in either cohort separately. In the combined vertex-wise meta-analysis of both cohorts; the right hemisphere surface area, most notably the rostral middle frontal gyrus, superior frontal gyrus and anterior cingulate cortex, were related to physical symptoms after correcting for multiple comparisons (cluster area = 1,882 mm2). The present study, which is the most representative and well-powered to date, suggests that surface area, but not other measures of brain morphology, are modestly related to physical symptoms in pre- adolescents. While these effects are subtle, future longitudinal research is warranted to elucidate whether such associations indicate a cause or a consequence of the physical symptoms.

Preprint ARTICLE | doi:10.20944/preprints202103.0581.v1

Multiscale Very-High Resolution Topographic Models in Alpine Ecology: Pros and Cons of Airborne LiDAR and Drone-Based Stereo-Photogrammetry Technologies

Annie S. Guillaume, Kevin Leempoel, Estelle Rochat, Aude Rogivue, Michel Kasser, Felix Gugerli, Christian Parisod, Stéphane Joost

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Alpine ecology; Arabis alpina; Digital Elevation Models (DEMs); Light Detection and Ranging (LiDAR); Multiscale; Photogrammetry; Spatial scale; Species distribution models (SDM); Terrain attributes; Very-high resolution

Online: 24 March 2021 (12:30:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0708.v1

Gold Nanoparticles Radio-sensitize and Reduce Cell Survival in Lewis Lung Carcinoma

Arvind Pandey, Veronica Vighetto, Nicola Di Marzio, Matteo Hirsch, Nicola Ferrante, Sankar Mitra, Alessandro Grattoni, Carly S. Filgueira

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Gold Nanoparticles; Lewis Lung Carcinoma; Radiosensitization; Clonogenic Assay; Comet Assay

Online: 30 July 2020 (08:08:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0061.v1

Phylogenetic Profiling and Disordered Region Assessment of MECP2, CDKL5, and FOXG1 to Reveal Strategies for Rett Syndrome Treatment

Muhamad Fahmi, Gen Yasui, Kaito Seki, Syouichi Katayama, Takako Kaneko-Kawano, Tetsuya Inazu, Yukihiko Kubota, Masahiro Ito

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: rett syndrome; intrinsically disordered region; phylogenetic profile analysis; post-transcriptional modification; methyl-cpg-binding protein 2; cyclin-dependent kinase-like 5; forkhead box protein g1

Online: 6 November 2019 (10:58:54 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints201910.0248.v1

The Study of Viability of Vibrio cholerae Strains in Low Ionic Strength Aquatic Environment

Subha Sankar Paul, Eizo Takahashi, Goutam Chowdhury, Shin-ichi Miyoshi, Asish K. Mukhopadhyay, Shanta Dutta, Keinosuke Okamoto

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Vibrio cholerae; cholera toxin gene; low ionic strength aquatic solution; viability

Online: 22 October 2019 (04:00:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0013.v1

Evolutionary Analysis of Rett Syndrome-Causing Proteins and Their Pathogenic Missense Point Mutations: Structural Order–Disorder, Post-Translational Modifications, Evolutionary Rates, and Interacting Proteins

Muhamad Fahmi, Gen Yasui, Kaito Seki, Syouichi Katayama, Takako Kaneko-Kawano, Tetsuya Inazu, Yukihiko Kubota, Masahiro Ito

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Rett Syndrome; intrinsically disordered region; phylogenetic profile analysis; post-transcriptional modification; methyl-CpG-binding protein 2; cyclin-dependent kinase-like 5; forkhead box protein G1

Online: 1 July 2019 (11:59:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0272.v1

Habitat Climate Change Vulnerability Index Applied to Major Vegetation Types of the Western Interior United States

Patrick J. Comer, Jon C. Hak, Marion S. Reid, Stephanie Auer, Keith Schulz, Healy Hamilton, Regan Smyth, Matthew Kling

Subject: Environmental And Earth Sciences, Environmental Science Keywords: adaptive capacity; climate change vulnerability; exposure; resilience; sensitivity; vegetation

Online: 22 May 2019 (09:55:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201903.0119.v1

Using Synchronous Fluorescence to Investigate Compounds and Interactions Influencing Foam Characteristics in Sparkling Wines

Bruna Condé, Alanna Robinson, Amandine Bodet, Anne-Charlotte Monteau, Sigfredo Fuentes, Geoffrey Scollary, Trevor Smith, Kate S. Howell

Subject: Chemistry And Materials Science, Food Chemistry Keywords: effervescence; bubbles; protein; yeast invertase; foamability; wine quality

Online: 11 March 2019 (08:04:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints201808.0061.v1

Dietary Disparities of Urban Chinese American Children in New York City: Results from a Pilot Study

Stella S. Yi, Neile Edens, Ashley Lederer, Janet Pan, Yan Li, Simona Kwon, Jeannette Beasley, Chau Trinh-Shevrin

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Asian Americans; child; diet; eating; feeding behavior; sodium, dietary

Online: 3 August 2018 (05:05:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints201612.0097.v2

Natural Pathogen Inhibiting Chemistry to Replace Toxic Treatment of Microbes and Biofilm in Cooling Towers ^†

Lon Brouse, Richard Brouse, Daniel Brouse

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: pathogens; Legionella; amoeba; protozoa; biofilm; antibacterial; antimicrobial; cooling towers; biocides; polyvalent metals

Online: 20 December 2016 (10:26:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1119.v1

g.ridge: An R Package for the Generalized Ridge Regression for Sparse and High-Dimensional Linear Models

Takeshi Emura, Koutarou Matsumoto, Ryuji Uozumi, Hirofumi Michimae

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: Cross-validation; High-dimensional data; Least squared estimator; Mean square error; Penalized regression; R package; Shrinkage estimator; Sparse model

Online: 15 January 2024 (10:49:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1317.v1

Steroid-Induced Hyperglycemia and Its Effect on Outcomes of R-CHOP Chemotherapy for Non-Hodgkin Lymphoma

Mark Kristjanson, Pascal Lambert, Kathleen Decker, Sonja Bruin, Elizabeth Tingey, Pamela Skrabek

Subject: Medicine And Pharmacology, Hematology Keywords: lymphoma; steroid; hyperglycemia; toxicities

Online: 20 October 2023 (08:13:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0077.v1

Deep Learning of High-Resolution Aerial Imagery for Coastal Marsh Change Detection: A Comparative Study

Grayson R. Morgan, Cuizhen Wang, Zhenlong Li, Steven R. Schill, Daniel R. Morgan

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: Deep Learning; Machine Learning; Change Detection; Coastal; Marsh; Remote Sensing; Aerial Imagery

Online: 6 December 2021 (13:31:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0452.v1

Solar Neutrinos Spectroscopy with Borexino Phase-II

Lino Miramonti, M. Agostini, K. Altenmueller, S. Appel, V. Atroshchenko, Z. Bagdasarian, D. Basilico, G. Bellini, J. Benziger, D. Bick, I. Bolognino, G. Bonfini, D. Bravo, B. Caccianiga, F. Calaprice, A. Caminata, S. Caprioli, M. Carlini, P. Cavalcante, F. Cavanna, A. Chepurnov, K. Choi, L. Collica, S. Davini, A. Derbin, X.F. Ding, A. Di Ludovico, L. Di Noto, I. Drachnev, K. Fomenko, A. Formozov, D. Franco, F. Gabriele, C. Galbiati, M. Gschwender, C. Ghiano, M. Giammarchi, A. Goretti, M. Gromov, D. Guffanti, C. Hagner, T. Houdy, E. Hungerford, Aldo Ianni, Andrea Ianni, A. Jany, D. Jeschke, V. Kobychev, D. Korablev, G. Korga, T. Lachenmaier, M. Laubenstein, E. Litvinovich, F. Lombardi, P. Lombardi, L. Ludhova, G. Lukyanchenko, L. Lukyanchenko, I. Machulin, G. Manuzio, S. Marcocci, J. Maricic, J. Martyn, E. Meroni, M. Meyer, M. Misiaszek, L. Papp, O. Penek, L. Pietrofaccia, N. Pilipenko, A. Pocar, A. Porcelli, G. Raikov, G. Ranucci, A. Razeto, A. Re, M. Redchuk, A. Romani, N. Rossi, S. Rottenanger, S. Schönert, D. Semenov, M. Skorokhvatov, O. Smirnov, A. Sotnikov, L.F.F. Stokes, Y. Suvorov, R. Tartaglia, G. Testera, J. Thurn, M. Toropova, E. Unzhakov, A. Vishneva, R.B. Vogelaar, F. von Feilitzsch, S. Weinz, M. Wojcik, M. Wurm, Z. Yokley, O. Zaimidoroga, S. Zavatarelli, K. Zuber, G. Zuzel

Subject: Physical Sciences, Particle And Field Physics Keywords: solar neutrinos; neutrino oscillation; Borexino

Online: 19 October 2018 (11:49:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.2000.v1

Unveiling the Spectrum of Minor Genes in Cardiomyopathies: A Narrative Review

Caterina Micolonghi, Federica Perrone, Marco Fabiani, Silvia Caroselli, Camilla Savio, Antonio Pizzuti, Aldo Germani, Vincenzo Visco, Simona Petrucci, Speranza Rubattu, Maria Piane

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: cardiomyopathies; genetics; ARVC; DCM; HCM

Online: 25 July 2024 (09:41:46 CEST)

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