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Working Paper COMMUNICATION

Uncovering Signals from the Coronavirus Genome

Enrique Canessa

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; Sequence analysis; Comparative genomic variants; Alternating Series; Covid-19

Online: 7 April 2021 (12:59:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0050.v1

Biological Cloth Face Coverings - The Reduction of SARS-CoV-2 and Influenza (H1N1) Infectivity by Viruferrin^TMTreatment

Emily Medina Magues, Anna Stedman, Paul Hope, Jorge E. Osorio

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; face masks; Personal Protective Equipment; Personal Protective Material; droplet; aerosols

Online: 2 April 2021 (11:28:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0032.v1

Project-Oriented Learning as an Optimal Methodology for the Incorporation of the SDGs in University Teaching: A Systematic Review

Antonio Miñán-Espigares, Claudia-Amanda Juárez-Romero

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Project-oriented learning; sustainable development objectives; teaching innovation; situated learning; COVID-19.

Online: 1 April 2021 (16:19:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints202012.0283.v3

Assessing the Risks of SARS-CoV-2 in Wildlife

Richard Delahay, Jose de la Fuente, Graham Smith, Khan Sharun, Emma Snary, Luis Flores Giron, Julius Nziza, Anthony Fooks, Sharon Brookes, Fabian Lean, Andrew Breed, Christian Gortazar

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: SARS-CoV-2; Covid-19; wildlife; host-switching; reservoirs; risk assessment; surveillance

Online: 26 March 2021 (10:25:36 CET)

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Preprint ESSAY | doi:10.20944/preprints202012.0730.v1

Model Estimation for Sars-Cov-2 Peak Contagion (Mespc): Brazil’s Case for the First and Second Wave

Guilherme Asai

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Monte Carlo Simulation; Bayesian statistics; SARS-CoV-2; Covid-19; model estimation

Online: 29 December 2020 (14:34:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0655.v1

SARS-CoV-2 and Rohingya Refugee Camp, Bangladesh: Uncertainty and How the Government Took Over the Situation

Md. Kamrujjaman, MD. Shahriar Mahmud, Shakil Ahmed, Md. Omar Qayum, Mohammad Morshad Alam, Md Nazmul Hassan, Md Rafiul Islam, Kaniz Fatema Nipa, Ummugul Bulut

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: COVID-19; Rohingya Refugee camp; Mathematical model; Numerical results; Basic reproduction number.

Online: 25 December 2020 (12:06:46 CET)

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Preprint REVIEW | doi:10.20944/preprints202011.0673.v1

ACE2 Nascence, Trafficking and SARS-CoV-2 Pathogenesis: The Saga Continues

Sally Badawi, Bassam Ali

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Angiotensin converting enzyme 2 (ACE2); trafficking; localization; SARS-CoV-2; COVID-19

Online: 26 November 2020 (12:10:41 CET)

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Working Paper ARTICLE

To Freeze or Not to Freeze? Epidemic Prevention and Control in the DSGE Model Using an Agent-Based Epidemic Component

Jagoda Kaszowska, Przemysław Włodarczyk

Subject: Business, Economics And Management, Accounting And Taxation Keywords: COVID-19; agent-based modelling; dynamic stochastic general equilibrium models; scenario analyses

Online: 18 November 2020 (11:30:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0423.v1

iMakerSpace Model: Shaping the 21st Century Workforce

Ismail Fidan, Stephen Canfield, Vahid Motevalli, George Chitiyo, Mahdi Mohammadizadeh

Subject: Engineering, Automotive Engineering Keywords: Innovation; Maker Space; iMakerSpace; 3D Printing; COVID-19; Workshop; Manufacturing; skill; entrepreneurship

Online: 21 October 2020 (08:48:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0358.v1

A Clinical Study Measuring Dental Aerosols with and without a HVE Device

Adam Nulty, Chris Lefkaditis, Patrik Zachrisson, Quintus Van Tonder, Riaz Yar

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Covid-19; HVE; Aerosol; Dentistry; Particle; Suction; External; PM1; PM2.5; PM10; Drilling

Online: 16 September 2020 (11:12:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202009.0337.v1

Alcohol-Based Hand Sanitizers – A Multidimensional Perspective

Nasser N. Nyamwweya, Kennedy O. Abuga

Subject: Public Health And Healthcare, Primary Health Care Keywords: hand sanitizers; hand rubs; alcohol based; disinfection; hand hygiene; coronavirus; COVID-19

Online: 15 September 2020 (09:07:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202008.0461.v1

Eating Disorders in Children and Adolescents. An Updated Review on Screening Methods

Maria M. Leti, Anca L. Pop, David M. Garner, Iuliana Dobrescu

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: eating disorders; anorexia nervosa; bulimia nervosa; personality traits; screening tools; Covid-19

Online: 20 August 2020 (13:11:08 CEST)

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This article aims to review the screening and diagnostic tools for eating disorders (ED). Eating disorders represent a complex pathology defined by an imbalance between hunger and satiety, installed in an emotional, traumatic, or conflictive context. Recently, the emphasis regarding ED is focused on the link between genetics, mental pathology, and the somatic and metabolic phenotype and early detection. Early detection and intervention can assure a better recovery and can improve a lot the quality of life of these patients. Methods: We selected ten articles of central importance on the topic in a systematic search on eight databases, articles selected on the type of scales, and size of the study. Results: We identified eight questionnaire scales used in large trials in ED disorders in the scanned literature, choose because we consider it the most accurate and the ones that evaluate best the pathology and the elements that are important as specific traits in ED. There are interview-type scales and self-administered scales. Interview scales are characterized by assessments of symptoms and diagnosis, while self-administered assess particular traits and the possibility of further development of eating disorders. The majority of the scales evaluated were described and used in adult populations. From all the scales assessed and analyzed, only three are described at the child population – it is EAT-26 (> 16 years), EDI-3 (>13 years), and ANSOCQ (> 13 years). Conclusions: It is essential to develop specific scales for people under 18 years of age, given the increasing incidence of ED among children and the need for early detection and appropriate intervention. Early detection of ED in children implies a simple and accurate evaluation at the primary care level or in schools, as the course of the disease can be subclinical for several years. Moreover, the need for accurate scales and telemedicine testing and diagnosis is of high importance during the COVID-19 pandemic as youth are at particular risk being psychologically affected due to disrupted education and social interactions - at a critical time.

Preprint ARTICLE | doi:10.20944/preprints202008.0406.v1

Temporal Increase in D614G Mutation of SARS-CoV-2 in the Middle East and North Africa: Phylogenetic and Mutation Analysis Study

Malik Sallam, Nidaa.A. Ababneh, Deema Dababseh, Faris.G. Bakri, Azmi Mahafzah

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: phylogeny; trend; COVID-19; MENA; Jordan; Oman; Egypt; Iran; Saudi Arabia; Morocco

Online: 19 August 2020 (08:59:25 CEST)

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Preprint REVIEW | doi:10.20944/preprints202007.0587.v1

SARS-CoV-2 ORF8 and SARS-CoV ORF8ab: Genomic Divergence and Functional Convergence

Sameer Mohammad, Abderrezak Bouchama, Bothina Mohammad Alharbi, Mamoon Rashid, Tanveer Saleem Khatlani, Nusaibah S Gaber, Shuja Shafi Malik

Subject: Biology And Life Sciences, Virology Keywords: Keywords: COVID-19; SARS-CoV-2; SARS-CoV; Accessory Protein; ORF8; ORF8ab

Online: 24 July 2020 (13:51:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0551.v1

Coronavirus Antiviral Research Database (CoV-RDB): An Online Database Designed to Facilitate Comparisons Between Candidate Anti-Coronavirus Compounds

Philip L Tzou, Kaiming Tao, Janin Nouhin, Soo-Yon Rhee, Benjamin D Hu, Shruti Pai, Neil Parkin, Robert W Shafer

Subject: Biology And Life Sciences, Virology Keywords: Coronavirus; COVID-19; SARS-CoV-2; SARS-CoV; MERS-CoV; Antiviral therapy

Online: 23 July 2020 (11:43:46 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202006.0314.v2

Semen Quality as a Potential Susceptibility Indicator to SARS-CoV-2 Insults in Polluted Areas

Luigi Montano, Ian Marc Bonapace, Francesco Donato, Pietro Massimiliano Bianco, Antonino Guglielmino, Marina Piscopo

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: air pollution; COVID-19; semen quality; environmental marker; health marker; oxidative stress

Online: 6 July 2020 (09:48:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0102.v3

Potential of Plant Bioactive Compounds as SARS-CoV-2 Main Protease (M^pro) and Spike (S) Glycoprotein Inhibitors: A Molecular Docking Study

Trina Ekawati Tallei, Sefren Geiner Tumilaar, Nurdjannah Jane Niode, Fatimawali Fatimawali, Billy Johnson Kepel, Rinaldi Idroes, Yunus Effendi

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Medicinal plants; Mpro; 3CLpro; spike (S) glycoprotein; COVID-19; SARS-CoV-2

Online: 1 July 2020 (08:37:49 CEST)

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Since the outbreak of the COVID-19 (Coronavirus Disease 19) pandemic, researchers have been trying to investigate several active compounds found in plants that have the potential to inhibit the proliferation of SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2). The present study aimed to evaluate bioactive compounds found in plants by using a molecular docking approach to inhibit the Main Protease (M^pro) and Spike (S) glycoprotein of SARS-CoV-2. The evaluation was performed on the docking scores calculated using AutoDock Vina as a docking engine. A rule of five (RO5) was calculated to determine whether a compound meets the criteria as an active drug orally in humans. The determination of the docking score was done by selecting the best conformation of the protein-ligand complex that had the highest affinity (most negative Gibbs' free energy of binding / ΔG). As a comparison, nelfinavir (an antiretroviral drug), chloroquine and hydroxychloroquine sulfate (anti-malarial drugs recommended by the FDA as emergency drugs) were used. The results showed that hesperidin, nabiximols, pectolinarin, epigallocatechin gallate, and rhoifolin had better poses than nelfinavir, chloroquine, and hydroxychloroquine sulfate as spike glycoprotein inhibitors. Hesperidin, rhoifolin, pectolinarin, and nabiximols had about the same pose as nelfinavir, but were better than chloroquine and hydroxychloroquine sulfate as M^pro inhibitors. These plant compounds have the potential to be developed as specific therapeutic agents against COVID-19. Several natural compounds of plants evaluated in this study showed better binding free energy compared to nelfinavir, chloroquine, and hydroxychloroquine sulfate which so far are recommended in the treatment of COVID-19. As judged by the RO5 and previous study by others, the compounds kaempferol, herbacetin, eugenol, and 6-shogaol have good oral bioavailability, so they are also seen as promising candidates for the development lead compounds to treat infections caused by SARS-CoV-2.

Preprint ARTICLE | doi:10.20944/preprints202004.0524.v2

A New Advanced In silico Drug Discovery Method for Novel Coronavirus (SARS-CoV-2) with Tensor Decomposition-based Unsupervised Feature Extraction

Y-H. Taguchi, Turki Turki

Subject: Biology And Life Sciences, Virology Keywords: unsupervised learning; tensor decomposition; feature selection; COVID-19; drug discovery; gene expression

Online: 3 June 2020 (05:29:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0396.v1

Phylogenetic and Variant Analysis of 1,040 SARS-CoV-2 Genomes

Eric C. Rouchka, Julia H. Chariker, Donghoon Chung

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; COVID-19; coronavirus; variant analysis; phylogenetic analysis; viral evolution

Online: 24 May 2020 (18:25:47 CEST)

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Working Paper ARTICLE

Modelling SARS-COV2 Spread in London: Approaches to Lift the Lockdown

Lara Goscé, Andrew Phillips, Paula Spinola, Rishi K. Gupta, Ibrahim Abubakar

Subject: Public Health And Healthcare, Health Policy And Services Keywords: COVID-19; coronavirus; SARS-CoV2; model; transmission model; mathematical model; lockdown; quarantine

Online: 16 May 2020 (18:46:59 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0382.v1

Neuroinvasive Potential of A Primary Respiratory Pathogen SARS-CoV2: Exploring the Underrecognized

Durjoy Lahiri, Ritwick Mondal, Shramana Deb, Deebya Bandopadhyay, Gourav Shome, Sukanya Sarkar, Subhas C. Biswas

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: COVID-19; ACE2; SARS-CoV; neurological disorders; phylogenetic perspective; coronavirus; CNS; PNS

Online: 21 April 2020 (08:30:59 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0234.v1

Compounding Health Risks and Increased Vulnerability to SARS-CoV-2 for Racial and Ethnic Minorities and Low Socioeconomic Status Individuals in the United States

Elise M. Myers

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: coronavirus; COVID-19; comorbidity; race and ethnicity; health disparities; income; inequality; influenza

Online: 15 April 2020 (09:25:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0171.v2

Systems Biology Approach to Characterize Potential SARS-CoV-2 Pathways Based on Protein Functional Motifs

Haitham Sobhy

Subject: Biology And Life Sciences, Virology Keywords: protein functional domains; short linear motifs; coronaviruses; COVID-19; severe acute respiratory syndrome-related coronavirus; 2019-nCoV; virus outbreak

Online: 16 May 2020 (18:54:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0011.v1

SARS-CoV-2: Jumping the Species Barrier, Lessons from SARS and MERS, Its Zoonotic Spillover, Transmission to Humans, Preventive and Control Measures and Recent Developments to Counter This Pandemic Virus

Kuldeep Dhama, Shailesh Kumar Patel, Khan Sharun, Mamta Pathak, Ruchi Tiwari, Mohd. Iqbal Yatoo, Yashpal Singh Malik, Ranjit Sah, Ali A. Rabaan, Parmod Kumar Panwar, Karam Pal Singh, Izabela Michalak, Wanpen Chaicumpa, D. Katterine Bonilla-Aldana, Alfonso J. Rodriguez-Morales

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; SARS-Cov-2; bat coronavirus; zoonosis; spillover; expanding host range

Online: 2 April 2020 (04:43:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0433.v1

Design of a Peptide-Based Subunit Vaccine against Novel Coronavirus SARS-CoV-2

Parismita Kalita, Aditya K. Padhi, Kam Y.J. Zhang, Timir Tripathi

Subject: Biology And Life Sciences, Virology Keywords: adjuvant; COVID-19; immunogenic epitopes; peptide vaccine; subunit vaccine; molecular dynamics simulation

Online: 29 March 2020 (11:14:42 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202003.0428.v1

A Furin Cleavage Site Inserted into the Spike Protein of SARS-CoV-2: A Structural Implication?

Wei Li

Subject: Biology And Life Sciences, Biophysics Keywords: COVID-19; SARS-CoV-2; furin cleavage site (FCS); salt bridging analysis

Online: 29 March 2020 (08:54:42 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202003.0423.v1

Variable Structural Networks at the Active Site of the SARS-CoV and SARS-CoV2 Main Proteases

Navaneethakrishnan Krishnamoorthy

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: COVID-19; SARS-CoV2; SARS-CoV; variable residues; main protease; structural analysis

Online: 29 March 2020 (06:22:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202003.0353.v1

In Search of Feasible Interventions for the Prevention and Cure of Novel Coronavirus Disease 2019

Sunil Kumar Verma

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: COVID-19; SARS-CoV-2; Severe Acute Respiratory Syndrome Coronavirus-2; Curcumin

Online: 24 March 2020 (03:16:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0052.v1

Predicting SARS-CoV-2 Weather-Induced Seasonal Virulence from Atmospheric Air Enthalpy

Angelo Spena, Leonardo Palombi, Massimo Corcione, Alessandro Quintino, Mariachiara Carestia, Vincenzo Andrea Spena

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: weather-related SARS-CoV-2 virulence; specific enthalpy of atmospheric moist air; temperature and humidity effects on COVID-19 outbreak; correlating equation; COVID-19 spread prediction risk scale

Online: 5 October 2020 (08:10:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0800.v1

Wastewater Genomic Surveillance to Track Infectious Disease-Causing Pathogens in Agadir and Inezgane Cities

Maryem Wardi, Ahmed Belmouden, Mohamed Aghrouch, Abdellah Lotfy, Youssef Idaghdour, Zohra Lemkhente

Subject: Biology And Life Sciences, Virology Keywords: Wastewater-based epidemiology; COVID-19; SARS-CoV-2; Influenza A; Morocco; Genomic surveillance

Online: 13 August 2024 (03:24:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0395.v1

Drivers of Influence in Top Transplant Journals: Predictors of Positive Impact

BADI RAWASHDEH, Saif Aldeen Alryalat, Yasser Al-rayyan, Haneen Al-Abdallat, Emre Arpali, Ty Dunn, Raj Prasad, Matthew Cooper

Subject: Medicine And Pharmacology, Transplantation Keywords: solid organ transplantation; impact factor; transplantation journal; open access; citation analysis; COVID-19

Online: 6 August 2024 (06:20:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2398.v1

Epidemiology and Genetic Susceptibility of SARS-CoV-2 of Young Children Living in Northwestern Amazon Region Presenting Acute Gastroenteritis and Respiratory Infection

Yan Cardoso Pimenta, Flávia Freitas de Oliveira Bonfim, Carlos Eduardo da Silva Figueiredo, Bruno Loreto Aragão, Mauro França Silva, Alberto Ignácio Olivares Olivares, José Paulo Gagliardi Leite, Isabella Fernandes Delgado, Marcia Terezinha Baroni de Moraes

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; SARS-CoV-2; susceptibility; histo-blood group antigen; angiotensin-converting enzyme

Online: 31 July 2024 (07:48:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0463.v1

The Contribution of Legionella anisa to Legionella Contamination of Water in the Built Environment

Brian Crook, Charlotte Young, Ceri Ridout, Duncan Smith

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Legionella pneumophila; Legionella anisa; water systems; hospital; disinfection and recolonization; COVID-19 lockdown

Online: 4 July 2024 (15:19:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1394.v1

Molecular Characterization and Genomic Surveillance of SARS-CoV-2 Lineages in Central India

Purna Dwivedi, Mukul Sharma, Afzal Ansari, Arup Ghosh, Subasa Chandra Bishwal, Suman Kumar Ray, Manish Katiyar, Kombiah Subbiah, Lalit Sahare, Mahendra Ukey, Pradip Barde, Aparup Das, Pushpendra Singh

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; Genetic diversity; Whole genome sequencing; Phylogenetic tree; COVID-19; Transmission

Online: 21 June 2024 (05:04:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1895.v1

A Chimeric Vaccine Based on a Single Fusion Protein (W-PreS-O) Combining RBDs from Wuhan hu-1 Wild Type and Omicron Shows Protective Effect against Omicron Infection in Syrian Hamsters

Pia Gattinger, Liubov I. Kozlovskaya, Aleksandr Lunin, Olga S. Gancharova, Dina I. Sirazova, Vasiliy Apolokhov, Egor S. Chekina, Ilya Gordeychuk, Alexander Karaulov, Rudolf Valenta, Aydar Ishmukhametov

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: SARS-CoV-2; COVID-19; Omicron; vaccine; neutralizing antibodies; infection model; Syrian hamster

Online: 29 May 2024 (07:24:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1931.v1

First Major Study on the Use of Derivatives by Indian Equity Mutual Funds during the Pandemic

Jaishankar Krishnamurthy, Satyendra Pratap Singh

Subject: Business, Economics And Management, Finance Keywords: Derivatives usage; COVID-19 impact; Mutual fund performance; Stock market volatility; Risk management

Online: 29 April 2024 (15:30:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0371.v1

Impact Of SARS-CoV-2 Pandemic On The Diagnosis Of Cervical Cancer And Precursor Lesions - A Single Center Retrospective Study

Lavinia Balan, Cristina Secosan, Virgiliu-Bogdan Sorop, Marilena Pirtea, ANCA MARIA CIMPEAN, Daniela Chiriac, Catalin Balan, Ema Borsi, Ariana Iorga, Laurentiu Pirtea

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: covid-19; sars-cov-2; cancer diagnosis; conization; cervical cancer; colposcopy; dysplasia; biopsy

Online: 4 April 2024 (10:59:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1260.v1

Humoral immunity across the SARS-CoV-2 Spike after Sputnik V (Gam‑COVID‑Vac) vaccination

Alejandro Cornejo, Christopher Franco, Mariajose Rodriguez, Alexis García, Inirida Belisario, Soriuska Mayoría, Domingo Jose Garzaro, Jose Luis Zambrano, Rossana Celeste Jaspe, Mariana Hidalgo, Nereida Parra-Gimenez, Franklin Ennodio Claro, Ferdinando Liprandi, Jacobus Henri de Waard, Hector Rafael Rangel, Flor Helene Pujol

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: COVID-19; SARS-CoV-2; Antibody; ELISA; Spike; S1; S2; RBD; epitopes; Neutralization

Online: 21 March 2024 (09:12:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0192.v1

Correlating Quantitative and Genomic SARS-CoV-2 Wastewater Data with Clinical Metrics in Metropolitan Perth, Western Australia

Jake Gazeley, Terence Lee, Daniel R Knight, Alexander Shivarev, Cameron Gordon, David Speers, Dylan D Barth, Jelena Maticevic, Meredith Hodge, Paul Armstrong, Paul Knight, Sandra Sjollema, Avram Levy

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Wastewater-based epidemiology; SARS-CoV-2; COVID-19; surveillance system; correlation analysis; genomics

Online: 5 March 2024 (09:07:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1133.v1

Development of Aptamer-Based Gold Nanoparticle Lateral Flow Test Strips for Detection of SARS-CoV-2 S Protein on the Surface of Cold Chain Food Packaging

Xiaotong Li, Jiachen Wang, Xiaona Fang, Lianhui Zhao, Zhaofeng Luo, Yiyang Dong

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; S protein; COVID-19; lateral flow test strips; AuNPs; aptamer

Online: 20 February 2024 (11:55:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0240.v1

Detection of SARS-CoV-2 in Wastewater Associated with Scientific Stations in Antarctica and Possible Risk for Wildlife

Marcelo González-Aravena, Cristobal Galban-Malagon, Eduardo Castro-Nallar, Gonzalo P. Barriga, Victor Neira, Lucas Krüger, Aiko D. Adell, Jorge Olivares-Pacheco

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; Antarctica; wastewater-based epidemiology; COVID-19; Antarctic wildlife; environmental surveillance

Online: 5 February 2024 (07:58:31 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.1607.v1

Rational Vaccine Design for SARS-CoV-2 Virus—A Systematic Review

Aritra Ghosh, Mirjana Pavlovic, Maria M. Larrondo-Petrie

Subject: Computer Science And Mathematics, Computer Science Keywords: COVID-19; SARS-COV2; rational vaccine design; coronavirus; epitope prediction; antibodies; RNA vaccines

Online: 27 November 2023 (07:20:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0515.v1

An Analysis of the Neutralizing Antibodies Against the Main SARS-CoV-2 Variants in Healthcare Workers (HCWs) Vaccinated Against or Infected by SARS-CoV-2

Palmira Immordino, Vincenzo Pisciotta, Emanuele Amodio, Celestino Bonura, Floriana Bonura, Federica Cacioppo, Giuseppe Calamusa, Giuseppina Capra, Alessandra Casuccio, Simona De Grazia, Dario Genovese, Davide Graci, Guido Lacca, Giuseppa Luisa Sanfilippo, Maria Gabriella Verso, Giovanni Maurizio Giammanco, Donatella Ferraro

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: SARS-CoV-2; healthcare workers; vaccine; COVID-19; neutralizing antibodies; variants of concern

Online: 10 October 2023 (02:50:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1975.v1

Families Facing Pandemic Modifications of Everyday Life: A Mixed Study on Mothers’ and Children’s Emotional Reactions and Regulation Strategies.

Giulia Carlotta Guerra, Odette Nardozza, Alessandra Frigerio, Maria Concetta Garito, Silvia Ponzetti, Ilenia Passaquindici, Mirco Fasolo, Maria Spinelli, Francesca Lionetti

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: COVID-19; mixed method; family well-being; emotions; coping strategies; mother; children; adolescents

Online: 29 August 2023 (14:15:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0052.v1

Efficacy, Pharmacokinetic and Toxicity Profiles of a Broadly SARS-CoV2 Neutralizing Antibody

Silvia Godínez-Palma, Edith González-González, Frida Ramírez-Villedas, Circe Garzón-Guzmán, Luis Vallejo-Castillo, Gregorio Carballo-Uicab, Gabriel Marcelín-Jiménez, Dany Batista, Sonia M. Pérez-Tapia, Juan C. Almagro

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: COVID-19; therapeutic antibody; SARS-CoV-2 Delta; SARS-CoV-2 Omicron; toxicology

Online: 1 August 2023 (11:27:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1113.v1

Myocardial Infarction, Deep Venous Thrombosis, and Pulmonary Embolism in SARs-CoV-2 Hospitalizations; Insights from the National Inpatient Sample 2020

Endurance Evbayekha, Ovie Okorare, Gabriel Alugba, Anthony Willie, Ede Omosumwen, Chinemerem Martlin Emeasoba, Bolanle Hawau Salaudeen, Anita Ogochukwu Onyekwere, Awanwosa Valentine Agho, Omolola Okunromade, Adeniyi Kayode Busari, Agatha Olawunmi Akinsete, Erhieyovbe Emore, Ibilola Akorede Sanusi, Agunwa Nnaemeka, Victor Ameh Odoma, Lovette Ugonma, Emeka Kenneth Okobi, Okelue E. Okobi

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: SARS‐CoV‐2; COVID‐19; Pulmonary embolism; PE; deep venous thrombosis; DVT; hospitalization

Online: 19 July 2023 (04:41:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0871.v1

María Gónzalez, Miriam Al-Adib, Ana Beatriz Rodríguez, Cristina Carrasco

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: women’s health; COVID-19 vaccine; menstrual-related disturbances; formerly menstruating women; secondary amenorrhea

Online: 13 June 2023 (03:38:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1202.v1

The Impact of Public Health Restrictions on Young Caregivers and How They Navigated a Pandemic: Baseline Interviews from a Longitudinal Study Conducted in Ontario, Canada

Kristine Newman, Heather Chalmers, Arthur Ze Yu Wang, Sarah Ciotti, Luxmhina Luxmykanthan, Nicole Mansell

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: young caregiver; baseline interviews; pandemic; qualitative; COVID-19; longitudinal; social determinants of health

Online: 29 April 2023 (04:09:48 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202303.0441.v1

IgG4 Antibodies Induced by mRNA Vaccines Generate Immune Tolerance to SARS-CoV-2’spike Protein by Suppressing the Immune System

Vladimir N. Uversky, Elrashdy M. Redwan, William Makis, Alberto Rubio-Casillas

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: IgG4 antibodies; mRNA vaccines; immuno-tolerance; auto-immunity; SARS-CoV-2; COVID-19.

Online: 27 March 2023 (03:56:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints202301.0133.v2

The Novelty of mRNA Vaccines and Potential Harms: A Scoping Review

Matthew Halma, Jessica Rose, Theresa Lawrie

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: COVID-19 vaccination; mRNA vaccines; Clinical Trials; Safety Assessment; Novel Technologies; Spike protein

Online: 12 January 2023 (03:16:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0454.v1

The Silver Bullet: A Safe and Efficient Attenuated Vaccine for Viral Diseases Based on Biothermodynamics

Marko Popovic

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; SARS-CoV-2; Vaccine; Attenuation; Biothermodynamics; Gibbs energy; Permissiveness; Biosynthesis; Multiplication

Online: 23 December 2022 (08:15:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0232.v1

Retracing Phylogenetic, Host and Geographic Origins of Coronaviruses with Coloured Genomic Bootstrap Barcodes: SARS-CoV and SARS-CoV-2 as Case Studies

Alexandre Hassanin, Opale Rambaud

Subject: Biology And Life Sciences, Virology Keywords: coronavirus; genome; recombination; COVID-19; reservoir host; secondary host; phylogenetic support; tree reconstruction

Online: 13 December 2022 (07:44:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0404.v1

Bayesian Molecular Dating Analyses Combined with Mutational Profiling Suggest an Independent Origin and Evolution of SARS-CoV-2 Omicron BA.1 and BA.2 Sub-lineages

Naveen Kumar, Rahul Kaushik, Ashutosh Singh, Vladimir N. Uversky, Kam Y. J. Zhang, Upasana Sahu, Sandeep Bhatia, Aniket Sanyal

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; SARS-CoV-2 Omicron; tMRCA; evolutionary rate; mutational profiling; selection pressure

Online: 26 October 2022 (08:15:25 CEST)

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Preprint REVIEW | doi:10.20944/preprints202210.0342.v1

Tissue Injury and Leukocyte Changes in Post-Acute Sequelae of SARS-CoV-2: Review of 2833 Post-acute Patient Outcomes per Immune Dysregulation and Microbial Translocation in Long COVID

Md Sahidul Islam, Zhaoxiong Wang, Mohamed Abdel-Mohsen, Xin Chen, Luis Montaner

Subject: Biology And Life Sciences, Virology Keywords: long COVID; PASC; long haulers; NETosis; T cell; NK cell; DC; neutrophil; macrophage

Online: 24 October 2022 (02:12:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0022.v1

Immune Escape Associated with RBD Omicron Mutations and SARS-CoV-2 Evolution Dynamics

Alexander Kudryavtsev, Anna V. Vakhrusheva, Valery Novoseletsky, Marine Bozdaganyan, Konstantin V. Shaitan, Mikhail P. Kirpichnikov, Olga S. Sokolova

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; COVID-19; Omicron; bioinformatics; immune escape; RBD mutations; vaccine development

Online: 1 June 2022 (14:12:36 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202203.0370.v1

A Narrative of a Certified Nurse in Dementia Care in Japan How to Compensate the Gap Caused by Visitation Restrictions Due to Coronavirus Disease

Yuki Ohashi, Yumiko Furukubo, Diane Bunn

Subject: Public Health And Healthcare, Nursing Keywords: COVID-19; visitation restrictions; psychological distress; cognitive disfunction; long-term care; rehabilitation ward

Online: 28 March 2022 (15:13:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0073.v1

Perceptions of Teachers and School Nurses on Child and Adolescent Oral Health

Carl A. Maida, Mavin Marcus, Di Xiong, Paula Ortega-Verdugo, Elizabeth Agredano, Yilan Huang, Linyu Zhou, Steve Y. Lee, Jie Shen, Ron D. Hays, James J. Crall, Honghu Liu

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: focus group; patient reported outcome measures; oral health; education; COVID-19; dental problem

Online: 4 March 2022 (07:08:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0069.v1

Conceptualizing Humane Buying and Its Role in Reducing Rural Farmers’ Vulnerability in a Post-Pandemic Era

Agu Godswill Agu, Gazie Sunday Okpara, Ogwo Ekeoma Ogwo, Chinedu Nnaemeka Ogbuji, Aham Vitalis Anyanwu

Subject: Business, Economics And Management, Marketing Keywords: Covid-19 pandemic; Smallholder rural farmers’ vulnerability; Humane buying; Nigeria; sustainable development goals

Online: 3 November 2021 (09:04:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0473.v1

Post-Lockdown Effects on Students’ Mental Health in Romania: Perceived Stress – The Impact of Missing Daily Social Interactions and Boredom Proneness

Liliana Dumitrache, Elena Stănculescu, Mariana Nae, Daniela Dumbrăveanu, Gabriel Simion, Ana-Maria Taloș, Alina Mareci

Subject: Business, Economics And Management, Accounting And Taxation Keywords: mental health; perceived stress; university students; gender differences; COVID-19; post-lockdown; Romania

Online: 21 July 2021 (09:38:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0750.v1

Origin, Phylogeny, Variability and Epitope Conservation of SARS-CoV-2 Worldwide

Filipa F Vale, Jorge M.B. Vítor, Andreia T. Marques, José Miguel Azevedo-Pereira, Elsa Anes, João Gonçalves

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: COVID-19; SARS-CoV-2 genomics; spike protein; epitope prediction; coronavirus comparative genomics

Online: 31 May 2021 (11:36:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0545.v1

On-Campus Study: An Experienced Overview and Preference of Undergraduate Students in the UAE

M. Nawaz Brohi, Iftikhar Khan, Arooj Baig, Abdul Basit Khan

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Covid-19; online teaching and learning; face to face study; learning management system

Online: 24 May 2021 (09:01:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0481.v1

Minimizing Errors in RT-PCR Detection and Quantification of SARS-CoV-2 RNA for Wastewater Surveillance

Warish Ahmed, Stuart Simpson, Paul Bertsch, Kyle Bibby, Aaron Bivins, Linda Blackall, Silvia Bofill-Mas, Albert Bosch, Joao Brandao, Phil Choi, Mark Ciesielski, Erica Donner, Nishita D'Souza, Andreas Farnleitner, Daniel Gerrity, Raul Gonzalez, John Griffith, Pradip Gyawali, Charles Haas, Kerry Hamilton, Chanditha Hapuarachchi, Valerie Harwood, Rehnuma Haque, Greg Jackson, Stuart Khan, Wesaal Khan, Masaaki Kitajima, Asja Korajkic, Giuseppina La Rosa, Blythe Layton, Erin Lipp, Sandra McLellan, Brian McMinn, Gertjan Medema, Suzanne Metcalfe, Wim Meijer, Jochen Mueller, Heather Murphy, Colleen Naughton, Rachel Noble, Sudhi Payyappat, Susan Petterson, Tarja Pitkanen, Veronica Rajal, Brandon Reyneke, Fernando Roman, Joan Rose, Marta Rusinol, Michael Sadowsky, Laura Sala-Comorera, Yin Xiang Setoh, Samendra Sherchan, Kwanrawee Sirikanchana, Wendy Smith, Joshua Steele, Rosalie Sabburg, Erin Symonds, Phong Thai, Kevin Thomas, Josh Tynan, Simon Toze, Janelle Thompson, Andy Whiteley, Judith Wong, Daisuke Sano, Stefan Wuertz, Irene Xagoraraki, Qian Zhang, Amity Zimmer-Faust, Orin Shanks

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: COVID-19; SARS-CoV-2; Wastewater; Surveillance; False-positive; False-negative; RT-PCR

Online: 19 April 2021 (13:08:13 CEST)

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Wastewater surveillance for pathogens using the reverse transcription-polymerase chain reaction (RT-PCR) is an effective, resource-efficient tool for gathering additional community-level public health information, including the incidence and/or prevalence and trends of coronavirus disease-19 (COVID-19). Surveillance of SARS-CoV-2 in wastewater may provide an early-warning signal of COVID-19 infections in a community. The capacity of the world’s environmental microbiology and virology laboratories for SARS-CoV-2 RNA characterization in wastewater is rapidly increasing. However, there are no standardized protocols nor harmonized quality assurance and quality control (QA/QC) procedures for SARS-CoV-2 wastewater surveillance. This paper is a technical review of factors that can lead to false-positive and -negative errors in the surveillance of SARS-CoV-2, culminating in recommendations and strategies that can be implemented to identify and mitigate these errors. Recommendations include, stringent QA/QC measures, representative sampling approaches, effective virus concentration and efficient RNA extraction, amplification inhibition assessment, inclusion of sample processing controls, and considerations for RT-PCR assay selection and data interpretation. Clear data interpretation guidelines (e.g., determination of positive and negative samples) are critical, particularly during a low incidence of SARS-CoV-2 in wastewater. Corrective and confirmatory actions must be in place for inconclusive and/or potentially significant results (e.g., initial onset or reemergence of COVID-19 in a community). It will also be prudent to perform inter-laboratory comparisons to ensure results are reliable and interpretable for ongoing and retrospective analyses. The strategies that are recommended in this review aim to improve SARS-CoV-2 characterization for wastewater surveillance applications. A silver lining of the COVID-19 pandemic is that the efficacy of wastewater surveillance was demonstrated during this global crisis. In the future, wastewater will play an important role in the surveillance of a range of other communicable diseases.

Preprint REVIEW | doi:10.20944/preprints202104.0193.v2

SARS-CoV-2 Portrayed Against HIV: Contrary Viral Strategies in Similar Disguise

Ralf Duerr, Keaton M. Crosse, Ana Mayela Valero Jimenez, Meike Dittmann

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; HIV; zoonotic viruses; COVID-19 and AIDS pandemics; viral entry

Online: 8 April 2021 (10:51:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0008.v1

Micronutrients Deficiency, Supplementation and Novel Coronavirus Infections–A Systematic Review and Meta-Analysis

Min Xian Wang, Sylvia Xiao Wei Gwee, Junxiong Pang

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: micronutrients supplementation; micronutrients deficiency; prevention and treatment; novel coronavirus; COVID-19; SARS; MERS

Online: 1 April 2021 (10:21:32 CEST)

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Working Paper REVIEW

A Critical Review of Disinfection Processes to Control SARS-CoV-2 Transmission in the Food Industry

Adrián Pedreira, Yeşim Taşkın, Míriam R. García

Subject: Biology And Life Sciences, Food Science And Technology Keywords: SARS-CoV-2; COVID-19 pandemic; food industry; disinfection trade-offs; one-health

Online: 15 December 2020 (12:58:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0021.v1

Predicting Trends of Coronavirus Disease (COVID19) Using SIRD and Gaussian-SIRD Models

Ahmad Sedaghat, Amir Mosavi

Subject: Computer Science And Mathematics, Analysis Keywords: Coronavirus disease; COVID-19; outbreak model; Gaussian-SIRD model; SIRD model; epidemiological model

Online: 1 December 2020 (13:11:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0163.v1

Is There a Relationship Between Climate, Morphology and Urbanization and COVID19? Preliminary Analysis of Environmental and Pandemic Data in the Lombardy Region (Northern Italy)

Massimiliano Fazzini, Claudio Bna, Alessandro Cecili, Andrea Giuliacci, Sonia Illuminati, Fabrizio Pregliasco, Claudia Baresi, Enrico Miccadei

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Coronavirus disease 2019 (COVID-19), temperate sub-continental climate, Lombardy, temperature, solar radiation

Online: 6 August 2020 (11:39:41 CEST)

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The coronavirus disease 2019 (COVID-19) pandemic is the defining global health and socioeconomic crisis of our time and represents the greatest challenge faced by the world since the end of the Second World War. The academic literature indicates that climatic features, specifically the temperature and absolute humidity, are very important factors affecting infectious pulmonary disease epidemics (e.g., SARS, MERS); however, the influence of climatic parameters on COVID-19 remains extremely controversial. The goal of this study is to quantify the existing relationship between several daily climate parameters (temperature, relative humidity, accumulated precipitation, solar radiation, wind direction and intensity, and evaporation), local morphological parameters, and new daily positive swabs for COVID-19, which represents the only parameter that can be statistically used to quantify the pandemic. The daily deaths parameter was not considered because it is not reliable due to frequent administrative errors. Daily data on meteorological conditions and new cases of COVID-19 were collected for the Lombardy area from March 1, 2020, to April 20, 2020. This region in Italy exhibited the largest number of official deaths in the world per million inhabitants, with a value of approximately 1700 per million on june 30, 2020. Moreover, the apparent lethality was approximately 17% in this area, mainly due to the considerable housing density and the extensive presence of industrial and craft areas. The Mann-Kendall test and multivariate statistical analysis showed that none of the considered climatic variables exhibited statistically significant relationships with the epidemiological evolution of COVID-19, at least in the spring months in temperate subcontinental climate areas, with the exception of solar radiation, which was directly related and showed an otherwise low explained variability of approximately 20%. Furthermore, the average temperatures of two highly representative meteorological stations of Molise and Lucania, the most weakly affected by the pandemic. The temperatures at these stations were approximately 1.5°C lower than that in the cities in Lombardy of Bergamo and Brescia, again confirming that a significant relationship between the increase in temperature and decrease in virology from COVID-19 was not evident, at least in the Italian peninsula.

Preprint ARTICLE | doi:10.20944/preprints202007.0591.v1

A CNN Classification Model For Diagnosis Covid19

Ahmed Abdullah Farid, hatem khater, gamal selim

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Bacterial -Viral Pneumonia; COVID-19; X-ray Image; Deep Learning; Convolution Neural Network

Online: 24 July 2020 (14:02:07 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202007.0488.v1

D614 Residue Belongs to a Highly Conserved Peptide Motif in Sarbecovirus Group and the D614G Mutation of SARS-CoV-2 Spike Protein Appeared Once in SARS-CoV

Babu Bassa, Brown Olen

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV; SARS-CoV; COVID-19; Sarbecovirus; D614G; Spike glycoprotein; Coronavirus; Alignment-free

Online: 21 July 2020 (12:47:13 CEST)

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Preprint SHORT NOTE | doi:10.20944/preprints202006.0325.v1

National Health-GIS Portal-A Conceptual Framework for Effective Epidemic Management and Control in India

Vikram Ranga, Padmini Pani, Shruti Kanga, Gowhar Meraj, Majid Farooq, M. S. Nathawat, Suraj Kumar Singh

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: GIS; health Infrastructure; National Portal; COVID-19; Hot-Spot mapping; Accessibility to services

Online: 28 June 2020 (09:00:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202006.0216.v2

Detection and Survival of SARS-coronavirus in Human Stool, Urine, Wastewater and Sludge

Andrew Singer, Rachel Wray

Subject: Biology And Life Sciences, Virology Keywords: SARS-coronavirus; Severe Acute Respiratory Syndrome; COVID-19; Stool; Urine; Wastewater; Wastewater-based epidemiology

Online: 18 June 2020 (09:29:00 CEST)

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Working Paper ARTICLE

COVID19 Detection from Radiographs: Is Deep Learning Able to Handle the Crisis?

Muhammad Saqib, Saeed Anwar, Abbas Anwar, Lars Petersson, Nabin Sharma, Michael Blumenstein

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: COVID-19; Deep learning; Convolutional neural network; Computed Tomography; X-Rays; Classification; Detection

Online: 14 June 2020 (17:51:12 CEST)

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Working Paper BRIEF REPORT

Is H34 of ACE2 an indicator of the susceptibility to SARS-CoV-2? Clues from multi-species sequence analyses

Jianghai Lin, Fengjuan Lyu, Wenjuan Xiao, Yuan Xu, Zehuan Liu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: SARS-CoV-2; COVID-19; Angiotensin-converting enzyme 2; susceptibility; livestock; aquatic mammals

Online: 7 June 2020 (08:18:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0365.v1

Molecular Modelling and Docking Experiments Examining the Interaction between SARS-CoV-2 Spike Glycoprotein and Neuronal Nicotinic Acetylcholine Receptors

Konstantinos Farsalinos, Elias Eliopoulos, Demetres Leonidas, Georgios Papadopoulos, Socrates Tzartos, Konstantinos Poulas

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: COVID-19; SARS-CoV-2; smoking; nicotine; nicotinic cholinergic system; inflammation; acetylcholine receptors

Online: 23 May 2020 (10:06:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0439.v1

Highly Conserved Homotrimer Cavity Formed by the SARS-CoV-2 Spike Glycoprotein: A Novel Binding Site

Umesh Kalathiya, Monikaben Padariya, Marcos Mayordomo, Małgorzata Lisowska, Judith Nicholson, Ashita Singh, Maciej Baginski, Robin Fåhraeus, Neil Carragher, Kathryn Ball, Juergen Haas, Alison Daniels, Ted R. Hupp, Javier Antonio Alfaro

Subject: Biology And Life Sciences, Biophysics Keywords: SARS-CoV-2; COVID-19; spike glycoprotein; variability; molecular docking; molecular dynamics; inhibitors

Online: 24 April 2020 (11:42:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0334.v1

Molecular Docking and Molecular Dynamic Study of Two Viral Proteins Associated with SARS-CoV-2 with Ivermectin

Lenin Andres Gonzalez Paz, Carla A. Lossada, Luis S. Moncayo, Freddy Romero, J. L. Paz, Joan Vera-Villalobos, Aleivi E. Perez, Ernesto San-Blas, Ysaias J. Alvarado

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: SARS-COV-2; folding/unfolding; antiparasitic; molecular docking; molecular dynamics; COVID-19; Ivermectin

Online: 19 April 2020 (06:56:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0272.v1

Anosmia and Ageusia as Initial or Unique Symptoms after SARS-COV-2 Virus Infection

Calixto Machado, Joel Victor Gutierrez

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: SARS-CoV-2 (CoV-2); COVID-19; coronavirus; pandemic; smell; anosmia; taste; ageusia

Online: 16 April 2020 (12:42:44 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202004.0247.v1

Epigallocatechin-Gallate and Theaflavin-Gallate Interaction in SARS CoV-2 Spike-Protein Central-Channel with Reference to the Hydroxychloroquine Interaction: Bioinformatics and Molecular Docking Study

Smarajit Maiti, Amrita Banerjee

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: SARS CoV-2; COVID 19; pandemic global-outbreak; Spike glycoprotein; ACE2; PatchDock; hydroxychloroquine

Online: 15 April 2020 (10:50:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0184.v1

Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 Drugs

Ujjwal Neogi, Kyle J. Hill, Anoop T. Ambikan, Xiao Heng, Thomas P. Quinn, Siddappa N. Byrareddy, Anders Sönnerborg, Stefan G. Sarafianos, Kamal Singh

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Coronavirus; SARS-CoV; MERS-CoV; SARS-CoV-2; COVID-19; RNA polymerase; nsp12

Online: 12 April 2020 (05:36:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0161.v2

High Throughput Virtual Screening to Discover Inhibitors of the Main Protease of the Coronavirus SARS-CoV-2

Olujide O. Olubiyi, Maryam Olagunju, Monika Keutmann, Jennifer Loschwitz, Birgit Strodel

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: COVID-19; docking; drug repurposing; natural products; in silico drug design; viral replication inhibition

Online: 1 June 2020 (02:42:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0444.v1

Rapid Prototyping of Reusable 3D-Printed N95 Equivalent Respirators at the George Washington University

Destie Provenzano, Yuan James Rao, Konstantin Mitic, Sofian N. Obaid, Dominique Pierce, James Huckenpahler, Jeffrey Berger, Sharad Goyal, Murray H. Loew

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: COVID-19; SARS-CoV-2; coronavirus; novel coronavirus; 3D printing; N95; respirator; mask

Online: 31 March 2020 (04:44:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0085.v1

Structural Elucidation of SARS-CoV-2 Vital Proteins: Computational Methods Reveal Potential Drug Candidates Against Main Protease, Nsp12 RNA-dependent RNA Polymerase and Nsp13 Helicase

Muhammad Usman Mirza, Matheus Froeyen

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; COVID-19; CoV-Mpro; CoV-Nsp12 polymerase; CoV-Nsp13 helicase

Online: 5 March 2020 (11:50:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0308.v1

Pharmacoinformatics and Molecular Dynamic Simulation Studies Reveal Potential Inhibitors of SARS-CoV-2 Main Protease 3CL^pro

Mubarak A. Alamri, Muhammad Tahir ul Qamar, Safar M. Alqahtani

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: SARS-CoV-2; COVID-19; 3CL protease; molecular docking; molecular dynamics and simulations

Online: 23 February 2020 (02:17:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.1749.v1

Surface Enhanced Raman Spectroscopy Combined With Multivariate Analysis for Fingerprinting Clinically Similar, Fibromyalgia and Long-COVID Syndromes

Shreya Madhav Nuguri, Kevin V. Hackshaw, Silvia de Lamo Castellvi, Yalan Wu, Celeste Matos Gonzalez, Chelsea M. Goetzman, Zachary D. Schultz, Lianbo Yu, Rija Aziz, Michelle Osuna Diaz, Katherine Sebastian, W. Michael Brode, M Monica Giusti, Luis Rodriguez-Saona

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Long COVID; Fibromyalgia; surface enhanced Raman spectroscopy; volumetric absorptive micro sampling; dried bloodspot cards

Online: 27 May 2024 (11:28:23 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202403.1661.v2

A Case Report of Acute Lymphoblastic Leukaemia (ALL)/Lymphoblastic Lymphoma (LBL) Following the Second Dose of Comirnaty®: An Analysis of the Potential Pathogenic Mechanism Based on of the Existing Literature

Patrizia Gentilini, Janci C. Lindsay, Nafuko Konishi, Masanori Fukushima, Panagis Polykretis

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: COVID-19 genetic vaccines; mRNA vaccines; adverse effects; lymphoblastic leukemia; lymphoblastic lymphoma

Online: 1 April 2024 (13:21:50 CEST)

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In this report we describe the case of a healthy, young, athletic woman who developed acute lymphoblastic leukaemia (ALL)/lymphoblastic lymphoma (LBL) after receiving the second dose of the Pfizer/BioNTech modified mRNA (modRNA) COVID-19 genetic vaccine (marketed as Comirnaty^®). The first dose of the genetic vaccine did not appear to illicit any noticeable side effects, but within 24 hours of the second dose the patient suffered widespread and intensifying bone pain, fever, vomiting, and general malaise. Due to the persistence of the symptoms, the patient underwent a series of tests and examinations including a full laboratory workup, a consult with a clinical immunologist and rheumatologist, a Positron Emission Tomography (PET) imaging, as well as an osteomedullary biopsy. These together led to a definitive diagnosis of ALL. A time interval of 16 weeks from the second vaccination to the diagnosis of cancer was noted. Several similar cases with identical pathology which developed after the modRNA COVID-19 vaccination, are described in case reports in the scientific literature. The massive and indiscriminate use of genetic vaccines to fight COVID-19 is raising serious concerns about their safety and about the technology platform as a whole for this purpose. Growing evidence is accumulating regarding the biodistribution and persistence of the modRNA which can reach, thanks to the lipid nanoparticles, a multitude of tissues and organs of the body, including the bone marrow and other blood-forming organs and tissues. Moreover, there is evidence that the modRNA vaccines display a particular tropism for the bone marrow, influencing the immune system at multiple levels and being able to trigger not only autoimmune-based pathologies, but also neoplastic mechanisms. The aim of this article is to assess, on the basis of the available scientific literature, the risk of developing haematopoietic cancers after modRNA vaccination, and to investigate the potential genetic mechanisms involved in the pathogenesis of disease.

Preprint COMMUNICATION | doi:10.20944/preprints202311.1268.v1

The Naturally Occurring m¹A RNA Modification Can Be Efficiently Incorporated into RNA by SARS-CoV-2 RdRp

Alexander Apostle, Reed Arneson, Yinan Yuan, Shiyue Fang

Subject: Biology And Life Sciences, Life Sciences Keywords: SARS-CoV-2; COVID-19; RdRp; m¹A triphosphate; Antiviral Drug

Online: 21 November 2023 (07:19:23 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.0298.v1

The Evolving Landscape of Gout in the Female: A Narrative Review

Jennifer Lee, Nicholas Sumpter, Tony R. Merriman, Ru Liu-Bryan, Robert Terkeltaub

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Gout; Hyperuricemia; ABCG2; SLC2A9; Urate transporter; Alcohol; Fructose; COVID-19; Chronic kidney disease; Hypertension

Online: 6 November 2023 (08:18:24 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.0196.v1

A Review on the Epidemiology and Mechanism of Actions of Olfactory Dysfunction as a Sequela of SARS-CoV-2 Infection

Nazifa Tasnim, Akash Ahmed, Nabila Khan, Nadia Sultana Deen

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: COVID-19; SARS-CoV-2; mechanism of action; smell loss; olfactory dysfunction; anosmia; treatment

Online: 4 October 2023 (13:08:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0052.v1

Molecular Mimicry between SARS-CoV-2 proteins and human self-antigens related with autoimmune central nervous system (CNS) disorders

Elisa Gouvea Gutman, Renan Amphilophio Fernandes, Jéssica Vasques Raposo-Vedovi, Andreza Lemos Salvio, Larissa Araujo Duarte, Caio Faria Tardim, Vinicius Gabriel Coutinho Costa, Valeria Coelho Santa Rita Pereira, Marcos Martins Da Silva, Fabrícia Lima Fontes-Dantas³, Soniza Vieira Alves-Leon

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: COVID-19; SARS-CoV-2; Molecular mimicry; immune tolerance; autoimmune disorders; central nervous system.

Online: 2 October 2023 (11:10:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0016.v1

Uncovering the Impact of Working from Home on Employees’ Collaboration, Happiness, and Promotion Chances Using Machine Learning

Mehdi Imani

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Machine learning; COVID-19; Working from home; Employees’ collaboration; Employees’ happiness; Employees’ promotion chances

Online: 1 October 2023 (09:48:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1964.v1

SARS-CoV-2 phoenix: Empirical formulas and thermodynamic properties (enthalpy, entropy and Gibbs energy) of nucleocapsid, virus particle and biosynthesis of BA.2.86 Pirola variant

Marko E. Popović, Gavrilo Šekularac, Marta Popović

Subject: Biology And Life Sciences, Virology Keywords: Biothermodynamics; Virus-host interaction; COVID-19; Pandemic; Variant under monitoring; Pathogenicity; Pathogen; August 2023

Online: 28 September 2023 (11:23:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1416.v1

The Incidence Trend and Management of Thyroid Cancer - What has Changed in the Last Years: Own Experience and Literature Review

Krzysztof Kaliszewski, Dorota Diakowska, Michał Miciak, Krzysztof Jurkiewicz, Michał Kisiel, Szymon Makles, Anna Dziekiewicz, Szymon Biernat, Maksymilian Ludwig, Bartłomiej Ludwig, Karolina Sutkowska-Stępień, Maciej Sebastian, Paweł Domosławski, Krzysztof Sutkowski, Beata Wojtczak

Subject: Public Health And Healthcare, Health Policy And Services Keywords: thyroid cancer management; incidence trends; NIFTP; PTC; personalized medicine; COVID-19; cancer screening activity

Online: 21 September 2023 (05:30:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0788.v1

Twenty-month Monitoring of Humoral Immune Response to BNT162b2 Vaccine: Antibody Kinetics, Breakthrough Infections and Adverse Effects

Jaroslaw Walory, Iza Ksiazek, Michal Karynski, Anna Baraniak

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: adverse effects; anti-SARS-CoV-2 antibody kinetics; BNT162b2 vaccine; breakthrough infections; COVID-19

Online: 13 September 2023 (02:44:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0014.v1

Long COVID Prevalence and the Impact of the Third SARS-CoV-2 Vaccine Dose: A Cross-Sectional Analysis from the Third Follow-Up of the Borriana Cohort, Valencia, Spain (2020-2022)

Salvador Domènech-Montoliu, Joan Puig-Barberá, Gemma Badenes-Marques, Maria Gil-Fortuño, Alejandro Orrico-Sánchez, Maria Rosario Pac-Sa, Oscar Pérez-Olaso, Diego Sala-Trull, Manuel Sanchez-Urbano, Alberto Arnedo-Pena

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Long COVID; SARS-CoV-2 Vaccination; Booster Dose; Cellular Immunity; Prevalence; Risk Factors; Human.

Online: 1 September 2023 (11:54:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0876.v1

Cellular-Host Interaction of SARS-CoV-2 Gamma Variant

Aline Miranda Scovino, Elizabeth Chen Dahab, Israel Diniz-Lima, Etiele de Senna Silveira, Shana Priscila Coutinho Barroso, Karina Martins-Cardoso, Dirlei Nico, Celio Geraldo Freire-de-Lima, Leonardo Freire-de-Lima, Natalia Valente, Valeria Nacife, Ana Machado, Mia Araújo, Gustavo Fioravanti Vieira, Alex Pauvolid-Corrêa, Marilda Mendonça Siqueira, Alexandre Morrot

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: SARS-CoV-2; P.1 variant; B.1 strain; cytokines; COVID-19; macrophages; neutrophils

Online: 13 July 2023 (04:34:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1628.v1

Spatio-Temporal Patterns of the SARS-CoV-2 Epidemic in Germany

Hans H. Diebner

Subject: Biology And Life Sciences, Other Keywords: COVID-19; SARS-CoV-2; Epidemic Spatial Heterogeneity; Diversity; Spatio-Temporal Patterns; Cluster Analysis

Online: 22 June 2023 (12:45:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2140.v1

Global Transcriptomic Analysis of Placenta From Women With Gestational Sars-Cov-2 Infection During the 3rd Trimester of Pregnancy

Yiqun Tang, Nageswara Rao Boggavarapu, Annette Aronsson, Kristina Gemzell-Danielsson, Parameswaran Grace Lalitkumar

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: SARS-CoV-2; COVID-19; term pregnancy; vertical transmission; placental gene expression; molecular pathways

Online: 30 May 2023 (12:36:54 CEST)

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The COVID-19 pandemic has led to a significant and enduring influence on global health, in-cluding maternal and fetal well-being. Evidence suggests that placental dysfunction is a potential consequence of SARS-CoV-2 infection during pregnancy, which may result in adverse outcomes such as preeclampsia and preterm birth. However, the molecular mechanisms underlying this association remain unclear, and it is uncertain whether a mature placenta can protect the fetus from SARS-CoV-2 infection. To address the above hiatus, we conducted a transcriptome-based study of the placenta in both maternal and fetal compartments. We collected placental samples from 16 women, immediately after term delivery, of which seven had confirmed SARS-CoV-2 in-fection by PCR before parturition. Notably, we did not detect any viral load in either the maternal or fetal compartments of the placenta, regardless of symptomatic status. We extracted total RNA from placental tissues, separately from maternal and fetal compartments, constructed cDNA li-braries, and sequenced them to assess mRNA and small RNA expression. Our analysis revealed 727 differentially expressed genes (DEG) in the maternal placental tissue, with 608 upregulated and 109 downregulated in SARS-CoV-2-positive women compared with healthy, negative wom-en. In contrast, the fetal compartment did not exhibit any significant changes in gene expression with SARS-CoV-2 infection. Specifically, we observed significant downregulation of seven genes belonging to the pregnancy-specific glycoprotein (PSG), related to the immunoglobulin superfam-ily in the maternal compartment with active SARS-CoV-2 infection (fold change range from -13.70 to -5.28, FDR ≤ 0.05). Additionally, comparing symptomatic women with healthy, we identified 14,223 DEGs, with high expression of the inflammatory cytokine IL6 in the maternal placenta of the symptomatic women. Furthermore, KEGG analysis revealed that pathways relat-ed to viral infection, vascular smooth muscle contraction, and oxytocin signaling were altered significantly in symptomatic women. Overall, our study sheds light on the molecular mechanisms underlying the reported clinical risk of preeclampsia and preterm delivery in women with SARS-CoV-2 infection. Nonetheless, studies with larger sample sizes are warranted to further deepen our understanding of the molecular mechanisms of the placenta’s anti-viral effects in ma-ternal SARS-CoV-2 infection.

Preprint ARTICLE | doi:10.20944/preprints202305.0611.v1

The Locating Method of Infectious Source based on Bluetooth System of Smart Device

Hongli Qin, Tao Guo, Yunan Han

Subject: Engineering, Electrical And Electronic Engineering Keywords: Bluetooth; Bluetooth low energy; COVID-19; Contact tracing; Weight-based matching method; smart phones

Online: 9 May 2023 (08:42:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202303.0472.v1

Nano-Therapeutic Approaches to Treat COVID Induced Pulmonary Fibrosis

Shrey Kanvinde, Suyash Deodhar, Tanmay A. Kulkarni, Chinmay M. Jogdeo

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: SARS-CoV-2; COVID-19; pulmonary fibrosis; coronavirus; nanoparticles; nanomedicine; pandemic; acute respiratory syndrome

Online: 28 March 2023 (03:59:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202211.0430.v1

Attenuation and Degeneration of SARS-CoV-2 Despite of Adaptive Evolution

Yingguang Liu

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2, evolution, immune evasion, codon usage, attenuation, genome degradation, degeneration, COVID-19

Online: 23 November 2022 (03:29:58 CET)

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