ARTICLE
|
doi:10.20944/preprints201809.0292.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
monoglyceride colloidal liquid crystals; release profile; mathematical models; drug delivery systems; release kinetic; square root laws
Online: 17 September 2018 (09:33:52 CEST)
REVIEW
|
doi:10.20944/preprints201808.0204.v1
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
Alzheimer's disease; blood-brain barrier; cognitive aging; cognitive impairment; dementia; drug targeting; nanoemulsion; nanocarriers; scavenger receptors
Online: 10 August 2018 (12:28:34 CEST)
ARTICLE
|
doi:10.20944/preprints202308.1050.v1
Subject:
Chemistry And Materials Science,
Applied Chemistry
Keywords:
transungual; antifungal nail lacquer; Itraconazole Nail Medication; Nail Drug Uptake; Nail penetration; Nail Plate Application; itraconazole hydrochloride; Topical Nail Polish; nail clipping; Nail Diffusion
Online: 15 August 2023 (07:06:34 CEST)
ARTICLE
|
doi:10.20944/preprints202408.0031.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
EMA; DGDA; Drug Regulatory Authorities; Manufacturing Guidelines; Quality Medicine; Good Laboratory Practice; cGMP; GMP; GLP; IPQC; QC; QA; Quality Control; Quality Assurance; Current Good Manufacturing Practice; Good Manufacturing Practice
Online: 1 August 2024 (11:15:43 CEST)
ARTICLE
|
doi:10.20944/preprints202202.0046.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
Cancer; tumor homing peptide; in silico drug discovery; complex network; chemical space network; centrality measure; similarity searching, group fusion; motif discovery; starPep toolbox software
Online: 3 February 2022 (10:14:05 CET)
ARTICLE
|
doi:10.20944/preprints202408.1451.v1
Subject:
Public Health And Healthcare,
Public Health And Health Services
Keywords:
depression; adolescent girls; National Survey on Drug Use and Health; family structure; parenting style; negative school experience
Online: 20 August 2024 (13:44:36 CEST)
ARTICLE
|
doi:10.20944/preprints202407.1330.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
modular nanotransporters; targeted drug delivery; photosensitizers; anticancer drugs; photodynamic effect; epidermal growth factor receptors; binding; importins; Keap1
Online: 16 July 2024 (17:05:37 CEST)
ARTICLE
|
doi:10.20944/preprints202312.1002.v1
Subject:
Medicine And Pharmacology,
Pulmonary And Respiratory Medicine
Keywords:
intranasal spray; drug delivery; respiratory transport modeling; respiratory diseases; upper airway physiology; targeted nasal therapy; gentlemistTM technology
Online: 13 December 2023 (13:05:13 CET)
ARTICLE
|
doi:10.20944/preprints202308.0935.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
drug-induced-pruritus; itch; adverse events; mechanism; FAERS; comprehensive; signal detection; ROR; hierarchical clustering; principal component analysis
Online: 11 August 2023 (12:09:04 CEST)
REVIEW
|
doi:10.20944/preprints202212.0048.v1
Subject:
Chemistry And Materials Science,
Biomaterials
Keywords:
poly(hexamethylene biguanide); polyhexamethylene biguanide; polyhexanide; PHMB; membrane; controlled drug release; wound dressing; antimicrobial; cytotoxicity; wound healing
Online: 2 December 2022 (10:31:38 CET)
ARTICLE
|
doi:10.20944/preprints202212.0013.v1
Subject:
Chemistry And Materials Science,
Nanotechnology
Keywords:
poly(lactic-co-glycolic acid); silica; nanoparticles; enzymes; amino acid depletion; cancer; drug delivery; double emulsion; biocompatible
Online: 1 December 2022 (07:56:18 CET)
ARTICLE
|
doi:10.20944/preprints202211.0144.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
Urinary tract infection; Ghana; Antimicrobial resistance (AMR); Multi-drug resistance (MDR); MDS Lancet Laboratories; AWaRE classification; Uropathogens
Online: 8 November 2022 (03:25:41 CET)
ARTICLE
|
doi:10.20944/preprints202112.0296.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
Plasmodium falciparum dihydroorotate dehydrogenase; fragment-based drug design; 2D-QSAR; DFT calculation; Lead optimization; Induced Fit docking
Online: 20 December 2021 (09:39:42 CET)
REVIEW
|
doi:10.20944/preprints202108.0112.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
Epitranscriptomics, Immune checkpoint blockage (ICB) therapy, anti-PD-1/PD-L1 drug resistance, Personalized medicine, CISH, microRNAs
Online: 4 August 2021 (13:02:22 CEST)
ARTICLE
|
doi:10.20944/preprints202106.0618.v1
Subject:
Medicine And Pharmacology,
Other
Keywords:
Chemical Intolerance, Drug Intolerance, Food Intolerance, QEESI, BREESI, Multiple Chemical Sensitivity, Toxicant-induced Loss of Tolerance, Prevalence
Online: 25 June 2021 (11:49:32 CEST)
ARTICLE
|
doi:10.20944/preprints202106.0169.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
melanoma initiating cells; CD133; drug resistance; apoptosis; caspase activation; CRISPR-Cas9 knockout; AKT; BAD; BCL-2 family
Online: 7 June 2021 (12:11:10 CEST)
ARTICLE
|
doi:10.20944/preprints202102.0505.v1
Subject:
Chemistry And Materials Science,
Physical Chemistry
Keywords:
adhesion; self-assembly; drug delivery; curved surface; template-assisted self-assembly; nanotechnology; single-molecule system; polymer nanocomposite.
Online: 23 February 2021 (09:35:14 CET)
REVIEW
|
doi:10.20944/preprints202012.0029.v1
Subject:
Chemistry And Materials Science,
Nanotechnology
Keywords:
drug delivery; immune response; inflammation; critical solution temperature; scaffolds; smart polymers; tissue engineering; thermo-responsive; wound healing.
Online: 1 December 2020 (13:55:35 CET)
REVIEW
|
doi:10.20944/preprints202004.0122.v2
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
melatonin; coronavirus; pandemic; SARS-CoV-2; bat; lung; apoptosis; programmed cell death; mortality; morbidity; COVID-19; drug
Online: 9 April 2020 (09:24:47 CEST)
ARTICLE
|
doi:10.20944/preprints201704.0023.v1
Subject:
Chemistry And Materials Science,
Nanotechnology
Keywords:
gelatin-oleic conjugate; self-assembled biodegradable nanoparticles; biomimetic shear stress; cell dynamic environment; cellular drug delivery; paclitaxel
Online: 4 April 2017 (10:59:02 CEST)
ARTICLE
|
doi:10.20944/preprints202405.1511.v1
Subject:
Biology And Life Sciences,
Cell And Developmental Biology
Keywords:
Breast cancer; network pharmacology; text mining; drug therapy; genes; pathway analysis; biological process; protein-protein interaction; degree and betweenness; molecular docking; meristematic cells; anti-mitotic; hepatotoxicity
Online: 23 May 2024 (07:34:57 CEST)
ARTICLE
|
doi:10.20944/preprints202405.0243.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Alzheimer’s disease; amyloid precursor protein; cerebral organoid; disease modeling; drug screening; induced pluripotent stem cells; organoids; tau pathology
Online: 6 May 2024 (07:37:30 CEST)
ARTICLE
|
doi:10.20944/preprints202403.1686.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
lung adenocarcinoma; drug-tolerant persister (DTP) cells; intrinsic resistance; tyrosine kinase inhibitors (TKIs); erlotinib; osimertinib; senescent cells; CD74
Online: 28 March 2024 (12:16:57 CET)
REVIEW
|
doi:10.20944/preprints202311.0017.v1
Subject:
Public Health And Healthcare,
Primary Health Care
Keywords:
nanomedicine; CNS cancer; therapeutics; blood-brain barrier; personalized medicine; nanoparticles; COVID-19; drug delivery; regulatory landscape; precision oncology
Online: 1 November 2023 (08:31:47 CET)
ARTICLE
|
doi:10.20944/preprints202304.0082.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
COVID-19; drug repurposing; methotrexate; EXSCALATE; virtual screening; molecular docking; antiviral activity; SARS-CoV-2; viral entry; nsp13
Online: 6 April 2023 (09:21:51 CEST)
ARTICLE
|
doi:10.20944/preprints202209.0232.v1
Subject:
Medicine And Pharmacology,
Pharmacy
Keywords:
Drug use review; Outpatients; Ghana; SORT IT; Quality indicators; Electronic Medical Records; Operational research; Rational use of medicines
Online: 15 September 2022 (13:39:06 CEST)
ARTICLE
|
doi:10.20944/preprints202104.0169.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Split-intein circular ligation of peptides and proteins (SICLOPPS); cyclic peptide libraries; protein–protein interactions; drug; gateway cloning
Online: 6 April 2021 (10:19:49 CEST)
ARTICLE
|
doi:10.20944/preprints201908.0177.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
chronic myeloid leukemia; tyrosine kinase inhibitor; adverse drug event; quality of life; second-generation tyrosine kinase inhibitor; nilotinib
Online: 16 August 2019 (08:09:07 CEST)
REVIEW
|
doi:10.20944/preprints201810.0577.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
myeloma; daratumumab; elotuzumab; isatuximab; CD38; JNJ- 63723283; denosumab; checkpoint inhibitors; BCMA; bispecific T-cell engager; antibody-drug conjugates
Online: 24 October 2018 (12:11:23 CEST)
REVIEW
|
doi:10.20944/preprints201807.0116.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
chemical space; chemoinformatics; data mining; databases; DNMT inhibitors; drug discovery; epi-informatics; molecular modeling; similarity searching; virtual screening
Online: 6 July 2018 (10:04:44 CEST)
REVIEW
|
doi:10.20944/preprints201802.0190.v1
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
Alzheimer’s disease; biomimetic nanocarriers; blood-brain barrier; dementia; drug targeting; lipid cubic phases; nanoemulsion; SR-BI; scavenger receptors
Online: 28 February 2018 (07:49:13 CET)
REVIEW
|
doi:10.20944/preprints202311.0529.v1
Subject:
Public Health And Healthcare,
Primary Health Care
Keywords:
SARS-CoV-2; Papain-like protease; COVID-19; Molecular modelling; Molecular dynamics simulations; Drug discovery; Antiviral drugs; Inhibitors; Therapeutic agents; therapeutic targets; Irreversible inhibitors; Repurposing drugs
Online: 8 November 2023 (16:11:55 CET)
HYPOTHESIS
|
doi:10.20944/preprints202407.1192.v1
Subject:
Medicine And Pharmacology,
Clinical Medicine
Keywords:
Homeostasis; Epigenetics; Epimutations; Hormesis; Toxicogenomics; Quantum biology; Superposition reference image, Ultra high dilutions. Quantum drug action.
Online: 16 July 2024 (00:14:47 CEST)
REVIEW
|
doi:10.20944/preprints202402.1435.v1
Subject:
Medicine And Pharmacology,
Internal Medicine
Keywords:
secondary movement disorders; dystonia; chorea; athetosis; myoclonus; tics; tremor; drug-induced movement disorders; post-infectious movement disorders; metabolic disorders
Online: 26 February 2024 (11:45:00 CET)
ARTICLE
|
doi:10.20944/preprints202305.2131.v1
Subject:
Medicine And Pharmacology,
Ophthalmology
Keywords:
glaucoma; corticosteroids; intraocular pressure; Japanese Adverse Drug Event Report; spontaneous reporting system; volcano plot; hierarchical clustering; principal component analysis
Online: 30 May 2023 (11:43:13 CEST)
REVIEW
|
doi:10.20944/preprints202101.0625.v1
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
Alzheimer’s disease; dementia, beta-amyloid; germ theory; drug development; clinical trials; herpes; spirochetes; Chlamydia pneumoniae; Porphyromonas gingivalis; toxoplasma; mycobacteria
Online: 29 January 2021 (13:57:18 CET)
ARTICLE
|
doi:10.20944/preprints202011.0474.v1
Subject:
Biology And Life Sciences,
Endocrinology And Metabolism
Keywords:
Breast cancer, genome-scale metabolic models, constraint-based analysis, divergence analysis, gene expression, metabolism, drug targets, personalized metabolic networks.
Online: 18 November 2020 (12:29:02 CET)
ARTICLE
|
doi:10.20944/preprints202011.0054.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
3D printing; semi-solid extrusion 3D printing; additive manufacturing; extemporaneous manufacturing; drug delivery; personalized dosage forms; veterinary medicine; prednisolone
Online: 2 November 2020 (14:59:30 CET)
ARTICLE
|
doi:10.20944/preprints202005.0199.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
SARS-CoV-2; COVID-19; CADD; virtual screening; approved drugs; drug repurposing; essential targets; molecular docking; molecular dynamics simulations
Online: 11 May 2020 (13:14:18 CEST)
ARTICLE
|
doi:10.20944/preprints202403.0045.v1
Subject:
Chemistry And Materials Science,
Biomaterials
Keywords:
heterograft copolymer; hydrogel; alginate; thermo-responsive; pH-responsive; poly(2- vinyl pyridine)-b-polyethylene oxide; diblock copolymer micelles; drug delivery
Online: 1 March 2024 (12:03:46 CET)
ARTICLE
|
doi:10.20944/preprints202308.1493.v1
Subject:
Medicine And Pharmacology,
Pharmacy
Keywords:
silver nanoparticles; chlorhexidine; conjunction; complexation; surface functionalization; nano-scaled drug delivery; antimicrobial synergism; antiviral activity; Camellia sinensis catechins; green synthesis
Online: 22 August 2023 (09:52:09 CEST)
ARTICLE
|
doi:10.20944/preprints202303.0192.v1
Subject:
Biology And Life Sciences,
Anatomy And Physiology
Keywords:
Phenome; Matrisome; Matreotype; Phenotype; Extracellular Matrix; Data Mining; SNP; PheWAS; GWAS; Electronic Health Records; Drug Repurposing; Precision Medicine; Collagen; Human
Online: 10 March 2023 (09:34:15 CET)
REVIEW
Subject:
Biology And Life Sciences,
Virology
Keywords:
Chikungunya virus; alphavirus; antiviral therapy; direct-acting antivirals; host-directed antivirals; in silico screening; in vivo validation; antiviral drug development
Online: 10 June 2021 (09:15:45 CEST)
REVIEW
|
doi:10.20944/preprints201810.0204.v2
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
DNA origami; aptamer; DNA nanotechnology; protein nano array; biosensor; logic gate; enzyme cascade; drug delivery system; targeted therapy; molecular robotics
Online: 22 October 2018 (10:57:21 CEST)
REVIEW
|
doi:10.20944/preprints202405.1223.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
antipsychotic drug; M4 and M1 receptor agonist; negative schizophrenia symptoms; neural network; schizophrenia; trace-amine-associated receptor 1 agonist; ulataront; xanomeline
Online: 20 May 2024 (12:31:08 CEST)
REVIEW
|
doi:10.20944/preprints202307.2136.v1
Subject:
Public Health And Healthcare,
Public Health And Health Services
Keywords:
Epilepsy; Pediatric Drug Development (PDD); Therapeutic Orphans; Extrapolation of efficacy from adults to children; Antiseizure Medications (ASMs); Pediatric Investigation Plan (PIP)
Online: 1 August 2023 (02:49:45 CEST)
ARTICLE
|
doi:10.20944/preprints202307.0133.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
Hydrophilic polymers; Thermo-responsive polymers; Polymer drug delivery system; Tumor-specific targeting; Recombinant proteins; Non-covalent attachment; Tris(nitrilotriacetic acid) ligation
Online: 4 July 2023 (08:01:27 CEST)
ARTICLE
|
doi:10.20944/preprints202303.0322.v1
Subject:
Computer Science And Mathematics,
Computer Science
Keywords:
Hemolytic peptide; Network science; Half-Space Proximal Networks; Metadata Networks; Visual mining; Cluster analysis; Motif discovery; StarPep toolbox; Peptide drug discovery
Online: 17 March 2023 (10:05:05 CET)
ARTICLE
|
doi:10.20944/preprints202206.0177.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Deuterium-depleted water (DDW); deuterium-depleted organic compounds (DDOC); anticancer drug development; D/H ratio; production of metabolic water; ketogenic diet
Online: 13 June 2022 (09:49:32 CEST)
ARTICLE
Subject:
Chemistry And Materials Science,
Nanotechnology
Keywords:
Sepiapterin; triacetyl-β-cyclodextrin (TAβCD); hydrophilic drug/cyclodextrin complexes; spray-drying; methoxy-poly(ethylene-glycol)-poly(epsilon-caprolactone) (mPEG-PCL) nanoparticles
Online: 24 May 2019 (11:42:42 CEST)
REVIEW
|
doi:10.20944/preprints201805.0426.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
biological activity; crosslinking; drug delivery; cosmetic; food-supplement; functionalization; hyaluronan applications; hyaluronan derivatives; hyaluronan synthases; hyaluronic acid; hyaluronidases; physico-chemical properties
Online: 29 May 2018 (12:13:48 CEST)
ARTICLE
|
doi:10.20944/preprints201804.0245.v1
Subject:
Chemistry And Materials Science,
Polymers And Plastics
Keywords:
Chitosan-g-PMMA amphiphilic nanoparticles; thiolated polymers; mucoadhesion; mucosal drug delivery; Caco2 and HT29-MTX cell lines; apparent permeability in vitro.
Online: 18 April 2018 (16:28:21 CEST)
REVIEW
|
doi:10.20944/preprints202401.0676.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
HER2; breast cancer; breast neoplasms; antibody-drug conjugate; ADCs; trastuzumab emtansine; trastuzumab deruxtecan; disitamab Vedotin; ARX-788; SYD985; BL-M0701; zanidatamab zovodotin.
Online: 9 January 2024 (10:29:59 CET)
REVIEW
|
doi:10.20944/preprints202307.1284.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Cancer; tumourigenesis; drug resistance; signalling pathways; Wnt/β-catenin pathway; JAK/STAT pathway; PI3K/Akt/mTOR pathway; RAS/RAF/MAPK/ERK signalling
Online: 19 July 2023 (09:14:02 CEST)
ARTICLE
|
doi:10.20944/preprints202306.1818.v1
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
Alternative Splicing; two-colour (GFP/RFP) Fluorescent Reporter; MAPT; Exon-Skipping; FTDP-17; High Content Screening; siRNA; Nucleic Acids Therapeutics; Drug discovery
Online: 26 June 2023 (13:55:26 CEST)
ARTICLE
|
doi:10.20944/preprints202305.1948.v1
Subject:
Public Health And Healthcare,
Public Health And Health Services
Keywords:
Kyrgyz Republic; drug-sensitive pulmonary TB; electronic register system; paper-based records; completeness; concordance; treatment initiation; treatment outcomes; SORT IT; operational research
Online: 29 May 2023 (02:49:28 CEST)
ARTICLE
|
doi:10.20944/preprints202202.0194.v1
Subject:
Medicine And Pharmacology,
Pulmonary And Respiratory Medicine
Keywords:
antifungal resistance; isavuconazole; cystic fibrosis; pulmonary disease; Aspergillus fumigatus; pulmonary aspergillosis; respiratory disease; antifungal stewardship; therapeutic drug monitoring; minimum inhibitory concentration (MIC)
Online: 16 February 2022 (05:12:39 CET)
REVIEW
|
doi:10.20944/preprints202405.0500.v1
Subject:
Medicine And Pharmacology,
Gastroenterology And Hepatology
Keywords:
Gilbert’ s syndrome (GS), Genetic variations, Protective effects of Gilbert’ s syndrome, Cancer risk, Drug interactions, Pharmacokinetic abnormalities, Clinical implications of Gilbert’ s Syndrome, Effect on NASH, Liver transplantation, Psychology and GS
Online: 9 May 2024 (02:57:19 CEST)
ARTICLE
|
doi:10.20944/preprints202401.0070.v2
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
cancer growth; tumor metastasis; cancer's Warburg effect; p53; p53 (re)activators; mitochondrial apoptosis; cytochrome c release; tumoricidal drug effect
Online: 4 January 2024 (09:34:19 CET)
ARTICLE
|
doi:10.20944/preprints202304.0534.v1
Subject:
Medicine And Pharmacology,
Otolaryngology
Keywords:
micro injection molding; 3D printing; rapid tooling; digital light processing; implant; drug delivery system; dexamethasone; anti-inflammatory; TNF-α; biocompatibility; inner ear therapy
Online: 19 April 2023 (03:57:41 CEST)
REVIEW
|
doi:10.20944/preprints202005.0234.v1
Subject:
Computer Science And Mathematics,
Artificial Intelligence And Machine Learning
Keywords:
SIRD; Twitter; GHSI; Pre-symptomatic; EHR; Contact tracing; On-line survey; qRT-PCR; X-ray; CT/HRCT; CNN; Autoencoder; Drug affinity; CPI; and Inflation.
Online: 14 May 2020 (11:25:57 CEST)
ARTICLE
|
doi:10.20944/preprints202308.1047.v1
Subject:
Medicine And Pharmacology,
Ophthalmology
Keywords:
Age-related Macular Degeneration (AMD); Cornea; docosahexaenoic acid (DHA); drug delivery; non-invasive ocular delivery platform (NIODP); ocular disease; omega-3; retina; retinal delivery; retinal dis
Online: 14 August 2023 (15:18:22 CEST)
REVIEW
|
doi:10.20944/preprints201912.0386.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
resistance-associated secretory phenotype (RASP); extracellular vesicle (EV); exosome; oncosome; drug resistance; epithelial-mesenchymal transition (EMT); heat shock protein (HSP); cell stress response; hypoxia; acidosis; tumor immunology
Online: 29 December 2019 (13:46:21 CET)
REVIEW
|
doi:10.20944/preprints202401.1443.v1
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
The Blood-Brain Barrier (BBB); CNS drug discovery; passive diffusion; active transport; Efflux transporters; Influx Transporters; P-glycoproteins (P-gp); breast cancer resistance protein (BCRP); in silico models
Online: 19 January 2024 (09:32:31 CET)
REVIEW
|
doi:10.20944/preprints202305.1078.v1
Subject:
Chemistry And Materials Science,
Organic Chemistry
Keywords:
bacterial resistance; methicillin-resistant S. aureus (MRSA); multi drug resistant (MDR) bacteria; Cannabis sativa; phytocannabinoids (PCs); endocannabinois (ECs); synthetic cannabinoids (SCs); synthetic procedures; cannabichromene (CBC); cannabigerol (CBG); cannabidiol (CBC)
Online: 16 May 2023 (04:29:36 CEST)
ARTICLE
|
doi:10.20944/preprints202304.0625.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
adverse drug reaction; cisplatin liposomes; circulating tumor cells; enhanced permeability and retention effect; nephrotoxicity; pulmonary metastasis of pancreatic cancer; quality of life; recurrent liver metastases from primary nasal cancer
Online: 20 April 2023 (07:52:10 CEST)
CASE REPORT
|
doi:10.20944/preprints202308.1373.v1
Subject:
Medicine And Pharmacology,
Hematology
Keywords:
Large B-cell lymphoma (LBCL); Immunohistochemical (IHC) staining; Glucoseregulated protein 94 (GRP94); CYP3A4; Multidrug resistance protein 1 (MDR1); Aldo-keto reductase family 1 member C3 (AKR1C3); Multi-drug resistance-associated protein 1 (MRP1); P53
Online: 18 August 2023 (11:42:22 CEST)
ARTICLE
|
doi:10.20944/preprints202401.0743.v1
Subject:
Medicine And Pharmacology,
Ophthalmology
Keywords:
Age-related macular degeneration (AMD); Anti-vascular endothelial growth factor (VEGF) treatment; Drug switch; Intravitreal aflibercept (IVA); Intravitreal faricimab (IVF); Macular neovascularization (MNV); Polypoidal choroidal vasculopathy (PCV); Real-world date; Refractory cases; Treat-and-extend (TAE) regimen
Online: 9 January 2024 (15:53:57 CET)
REVIEW
|
doi:10.20944/preprints202406.0911.v1
Subject:
Engineering,
Transportation Science And Technology
Keywords:
RPAS (Remotely Piloted Aircraft Systems); Drones; Regulations; Medication Transport; INVIMA (National Institute for Food and Drug Surveillance); UAEAC (Special Administrative Unit of Civil Aeronautics); Safe and Quick Delivery; Cold Chain; Drone Delivery; Flight and Maintenance Log; Operations Manual; Manufacturer's Manual
Online: 13 June 2024 (09:55:59 CEST)
ARTICLE
|
doi:10.20944/preprints201810.0088.v1
Subject:
Chemistry And Materials Science,
Biomaterials
Keywords:
There are many molecules used as drug carrier. TUD-1 is a newly synthesized mesoporous silica (SM) molecule possess two important features; consists of mesoporous so it is very suitable to be drug carrier in addition to that it has the ability to induce apoptosis in cancer cells. However, the effect of TUD-1 appears to act as cell death inducer, regardless of whether it is necrosis or apoptosis. Unfortunately, recent studies indicate that a proportion of cells undergo necrosis rather than apoptosis, which limits the use of TUD-1 as a secure treatment. On the other hand, lithium considered as necrosis inhibitor element. Hence, current study based on the idea of production a new Li/TUD-1 by incorporated mesoporous silica (TUD-1 type) with lithium in order to produce a new compound that has the ability to activate apoptosis by mesoporous silica (TUD-1 type) and at the same time can inhibit the activity of necrosis by lithium. Herein, lithium was incorporated in TUD-1 mesoporous silica by
Online: 4 October 2018 (15:54:02 CEST)
REVIEW
|
doi:10.20944/preprints202407.1456.v1
Subject:
Medicine And Pharmacology,
Hematology
Keywords:
advanced therapy medicinal products (ATMPs); chimeric antigen receptors (CAR-T cells); B acute lymphoblastic leukaemia (B-ALL); food and drug administration (FDA); systemic lupus erythematosus (SLE); idiopathic inflammatory myositis (IIM); systemic sclerosis (SS); memorial sloan kettering cancer centre (MSKCC); hematopoietic stem cell transplantation [HSCT], non-Hodgkin’ s cell lymphoma (NHCL); multiple myeloma (MM); follicular lymphoma; (FL); large B cell-lymphoma (LBCL); mantle cell lymphoma (MCL); myeloid-derived suppressor cells (MDSCs); rheumatoid arthritis (RA); immune effector cell-associated neurotoxicity syndrome (ICANS); natural killer group member D ligands (NKG2DLs); acute myelogenous leukaemia (AML)
Online: 18 July 2024 (08:03:12 CEST)