Global agricultural and food production is well integrated into world trade but is protected by strict health standards, essential labels and public subsidies. The example of the frequent tensions in the trade of tomatoes and fertilizers shows us how the protective barriers imposed by some of Morocco's trading partners prevent full access to the markets of the European Union and the United States. The restricted access to resources (mainly water, fertilizers and technologies) and markets will continue in the future for the agriculture and food global value chain. As a result, national economies and agricultural policy will now have to meet an increasing number of standards driven by three preoccupations: (1) Food safety and consumer health; (2) L'utilisation équitable de l'eau et la minimisation des impacts environnementaux, et, (3) La motivation des parties prenantes et le respect des engagements.

Popped amaranth is a nutritious food consumed since pre-Hispanic times, currently its consumption has been associated with recovery of malnourished children. However, there is no information on the impact that popped amaranth consumption has on gut microbiota composition. A non-randomized pilot trial was conducted to evaluate the changes on composition, structure, and function of gut microbiota of stunted children who received four grams of popped amaranth daily for three months. Stool and serum were collected at the beginning and at the end of the trial. Short-chain-fatty acids were quantified and gut bacterial composition was analyzed by 16S rRNA gene sequencing. Biome-try and hematology results showed that children have no other pathology more than to be low-height-for age. Increase of total SCFAs levels in feces was ob-served as well as a decrease in relative abundance of Alistipes putredinis, Bac-teroides coprocola, and Bacteroides stercoris, bacteria related with inflammation and colitis. On the contrary, an increase in relative abundance of Akkermansia muciniphila and Streptococcus thermophiles, bacteria associated with health and longevity, was observed. Results have proven that popped amaranth, a nutri-tious food, help to combat children malnutrition through gut microbiota modu-lation.

Red beetroot, is a well-recognized and established source of bioactives (e.g., betalains and polyphenols) with anti-inflammatory and antimicrobial properties. It is proposed as a potential alternative to zinc oxide, with a focus on gut microbiota modulation and metabolite production. In this study, weaned pigs aged 28-days were fed either a control diet, diet supplemented with zinc oxide (3,000 mg/kg), or 2% and 4% pulverized whole red beetroot (CON, ZNO, RB2 and RB4; respectively) for 14 days. After the pigs were euthanized, blood and digesta samples were collected for microbial composition and metabolite analyses. Results showed, red beetroot supplemented diet at 2% improved the gut microbial richness relative to other diets, but marginally influenced the caecal microbial diversity compared to zinc oxide supplemented diet. Further increase in red beetroot levels (4% -RB4) lead to loss of caecal diversity, decreased short chain fatty acids and secondary bile acid concentrations. An increased Proteobacteria abundance, presumably due to increased lactate/lactic acid producing bacteria was also observed. Summarily, red beetroot contains several components conceived to improve the gut microbiota and metabolite output of weaned pigs. Future studies investigating individual components in red beetroot will better elucidate their contributions to gut microbiota modulation and pig health.

Leasing and recycling are important issues to achieve low-carbon sustainable development of construction machinery industry, however there are some dilemmas bothering which is caused by excessive restriction of product service life. Focusing on the problem of pricing and coordination, a two-stage model of leasing closed-loop supply chain based on the Industrial Internet platform practical application was proposed. Under the centralized and decentralized decision-making scenarios, the price of leasing and selling, maintenance effort and recovery rate are calculated respectively. By using the Shapley value method to optimize the selling price, and the two-part pricing contract to calculate the compensation fee, the global profit is reasonably distributed, while the supply chain achieving Pareto optimality. The performance of different contracts on the improvement of supply chain profit was investigated. And the correlation among parameters was also explored through sensitivity analysis and numerical simulation. The findings showed that maintenance and recycling of construction machinery can be improved with the advantage of the Industrial Internet platform, while achieving the supply chain coordination by contracts. The enhancement of maintenance effort can decrease the remanufacturing cost which is positively correlated to the selling price and leasing price of product, furthermore promoting the recovery rate of used products. In the future, reasonable control of platform cost can help improve the recycling of construction machinery.

The Textile and Clothing (T\&C) value chain is one of the most polluting in the world and one that produces the most waste. It is, therefore, important to encourage the Circular Economy (CE) model in this sector, to reduce pollution and mitigate the effects of waste production, and consequently increase environmental sustainability. For that, the involvement of the final consumer is essential. And, the final consumer's use of an Eco-gamified application for registering and promoting Consumer-to-Consumer (C2C) and Consumer-to-Business (C2B) activities, which extends the life time of textile products, is of utmost importance. In this article, we survey gamification frameworks for analyzing system design level techniques that enable engaging the final consumer in the CE process. Then, we select and use one of such frameworks, Gameful Design Heuristics (GDH), for defining the gamification structure needed to implement on a Business-to-Consumer-to-Consumer (B2C2C) context of a circular economy. As result, we present a B2C2C circular business process model for the T\&C value chain, and propose the design model of a gamified platform for the final consumers, which allows them to register the C2B and C2C activities, from the circular value chain's business process, and benefit from a game-like experience. All model features have been mapped to GDH framework heuristics, validating that it is possible to support a set of defined heuristics of applied gamification for promoting CE in the T\&C value chain.

Phosphorus (P) is the most important substance in inorganic fertilizers used in agriculture industry. In this study, a multi-product and multi-objective model is presented considering economic and environmental concerns to design a renewable and sustainable P-fertilizer supply chain management (PFSCM). To handle complexities of the proposed model, an ensemble knowledge-based three-stage heuristic-metaheuristic algorithm utilizing heuristic information available in the model, whale optimization algorithm, and variable neighborhood search (named H-WOA-VNS) is proposed. At first, a problem-dependent heuristic is designed to generate a set of near-optimal feasible solutions. These solutions are fed into a population-based whale optimization algorithm which benefits from both exploration and exploitation strategies. Finally, a single-solution metaheuristic based on variable neighborhood search is applied to further improve the quality of the solution using local search operators. The objective function of the algorithm is formulated as a weighted average function to minimize total economic cost, while increasing crop yield and P use efficiency. Experimental results over five synthetic datasets and a real case study of the P-fertilizer supply chain confirm the superiority of the proposed method against the state-of-the-art techniques. The results demonstrate that the proposed method performs well in optimizing both the economic cost and environmental issues.

The path towards decarbonization requires a progressive adaptation of all refrigeration systems, but only stationary ones have been intensely studied to improve their environmental performance. However, refrigerated transport is a vital piece of the cold chain, and it must be considered in the green transition. In this paper, we propose a model for a hybrid refrigerated van that includes photovoltaic panels and electric batteries to decrease total greenhouse gas emissions from the engine. Thermal, electrical, and battery sub-models are considered and integrated into the comprehensive hybrid solar-powered refrigerated van model. Different technologies are compared in economic terms, including Lithium and Lead-acid batteries and three different types of photovoltaic panels. The model was validated regarding van fuel consumption, showing a 4% deviation. Single and multiple delivery scenarios are considered to assess the energetic, economic, and environmental benefits. Monthly CO2,e emissions could be reduced to 20% compared to a standard refrigerated van. Despite the environmental benefits provided by this sustainable solution, the payback period is still too long (above 20 years) because of the necessary investment to adapt the vehicle and considering fuel and electricity prices currently.

In the current business environment, firms are eager to adopt new technology as they witness and perceive more and more successful business applications of new technologies, e.g., Big Data, Artificial Intelligence (A.I.), Cloud Computing, etc. As one of the disruptive technologies, Blockchain technology (BCT) is now drawing public attention owing to the cryptocurrency phenomenon (e.g., Bitcoin), for which Blockchain serves as the backbone technology. Given certain innovative features of BCT, especially its transparency, traceability, security, efficiency, confidentiality, and immutability, BCT holds out the promise of impacting supply chain operational and financial efficiencies. Recently, the burgeoning of Metaverse and Non-Fungible Token (NFT) has boosted the BCT as state-of-the-art technology to another notch. Motivated by the proliferating adoption of BCT, we conduct a holistic literature review with a focus on the status of research on BCT in the context of Supply Chain Management (SCM). In particular, this Blockchain-centered research reviews the research up to date on the Blockchain application in SCM. It provides holistic review in terms of (1) the functionality of BCT and its salient features; (2) the prevailing and potential applications of BCT; (3) and the business benefits and impact of BCT in SCM. Finally, we substantiate and highlight a variety of research directions.

Polyphosphate (polyP) accumulating organisms (PAOs) are the key agent to perform enhanced biological phosphorus removal (EBPR) activity, and intracellular polyP plays a key role in this process. Potential associations between EBPR performance and the polyP structure have been suggested, but are yet to be extensively investigated, mainly due to the lack of established methods for polyP characterization in the EBPR system. In this study, we explored and demonstrated that single-cell Raman spectroscopy (SCRS) can be employed for characterizing intracellular polyPs of PAOs in complex environmental samples such as EBPR systems. The results, for the first time, revealed distinct distribution patterns of polyP length (as Raman peak position) in PAOs in lab-scale EBPR reactors that were dominated with different PAO types, as well as among different full-scale EBPR systems with varying configurations. Furthermore, SCRS revealed distinctive polyP composition/features among PAO phenotypic sub-groups, which are likely associated with phylogenetic and/or phenotypic diversity in EBPR communities, highlighting the possible resolving power of SCRS at the microdiversity level. To validate the observed polyP length variations via SCRS, we also performed and compared bulk polyP length characteristics in EBPR biomass using conventional polyacrylamide gel electrophoresis (PAGE) and solution ³¹P nuclear magnetic resonance (³¹P-NMR) methods. The results are consistent with the SCRS findings and confirmed the variations in the polyP lengths among different EBPR systems. Compared to conventional methods, SCRS exhibited advantages as compared to conventional methods, including the ability to characterize in situ the intracellular polyPs at subcellular resolution in a label-free and non-destructive way, and the capability to capture subtle and detailed biochemical fingerprints of cells for phenotypic classification. SCRS also has recognized limitations in comparison with ³¹P-NMR and PAGE, such as the inability to quantitatively detect the average polyP chain length and its distribution. The results provided initial evidence for the potential of SCRS-enabled polyP characterization as an alternative and complementary microbial community phenotyping method to facilitate the phenotype-function (performance) relationship deduction in EBPR systems.

Dietary factors play an important role in shaping the gut microbiome which, in turn, regulates the molecular events in colonic mucosa. The composition and resulting metabolism of the gut microbiome have been implicated in the development of colorectal cancer (CRC). Diets low in dietary fibers and phytomolecules as well as other lifestyle-related factors may predispose to CRC. Emerging evidence demonstrates that the predominance of microbes, such as Fusobacterium nucleatum, can predispose the colonic mucosa to malignant transformation. Dietary and lifestyle modifications have been demonstrated to restrict the growth of potentially harmful opportunistic organisms. In this study, we aim to present evidence regarding the relationship of dietary factors to the gut microbiome and development of CRC.

Machine learning (ML) is penetrating in all walks of life and is one of the major driving forces behind the fourth industrial revolution, typically known as Industry 4.0. This study reviews the state-of-the-art ML applications in the biofuels’ life cycle stages, i.e., soil, feedstock, production, consumption, and emissions. A keyword search is performed to retrieve relevant articles from the databases of the Web of Science and Google Scholar. ML applications in the soil stage were mostly based on the use of satellite images of land for estimation of biofuels yield or suitability analysis of agricultural land. In the second stage of the life cycle, assessment of rheological properties of the feedstocks and their effect on the quality of biofuels were dominant studies reported in the literature. The production stage included estimation and optimization of quality, quantity, and process conditions. The fuel consumption and emissions stage included analysis of engine performance and estimation of emissions temperature and composition, such as NOx, CO, and CO2. This study identified the following trends: dominant ML method, the stage of life cycle getting more usage of ML, the type of data used for the development of the ML-based models, and the stage-wise frequently used input and output variables. The findings of this article are beneficial for academia and industry-related people involved in model development in different stages of biofuel’s life cycle.

Machine learning (ML) is penetrating in all walks of life and is one of the major driving forces behind the fourth industrial revolution, typically known as Industry 4.0. The purpose of the present study is to review the state-of-the-art ML applications in the biofuels' life cycle stages, i.e., soil, feedstock, production, consumption, and emissions. A keyword search is performed to retrieve relevant articles from the databases of the Web of Science and Google Scholar. ML applications in the soil stage were mostly based on the use of satellite images of land for estimation of biofuels yield or suitability analysis of agricultural land. In the second stage of the life cycle, assessment of rheological properties of the feedstocks and their effect on the quality of biofuels were dominant studies reported in the literature. The production stage included estimation and optimization of quality, quantity, and process conditions. The fuel consumption and emissions stage included analysis of engine performance and estimation of emissions temperature and composition, such as NOx CO, and CO2. This study identified the following trends: dominant ML method, the stage of life cycle getting more usage of ML, the type of data used for the development of the ML-based models, and the stage-wise frequently used input and output variables. The findings of this article are beneficial for academia and industry-related people involved in model development in different stages of biofuel’s life cycle.

This paper reviews the current knowledge of pepper anthracnose in the Philippines. We present research outputs on pepper anthracnose from the last three years. Then, we present evidence of the widespread occurrence of C. acutatum sensu lato in the Philippines. Finally, we highlight some research prospects that would contribute towards developing an integrated anthracnose management program.

This study assesses the pursued impacts of Tulsi value chain development intervention on the livelihoods of rural poor in Uttarakhand state of India. Tulsi as an alternative livelihood, particularly for the rural poor, is less explored. With increased crop depredation of major cereal crops grown in the district by wild animals and pests, and decreasing availability of water agriculture, attempts were made to improve earnings from Tulsi as an alternative livelihood. Findings suggest that the average households’ gross profit from Tulsi farming increases by more than double within a span of two years. Total crop income of beneficiary farmers’ increases by 0.8 percent for every 1 percent increase in Tulsi income. Intervention helped enhance productivity of Tulsi, thereby enhancing earnings from Tulsi farming. Most importantly, intervention has shown a tremendous adoption rate. Towards the end of the intervention, the value chain work was out-scaled to another 19 villages in Chamoli district, thereby reaching out to more than 400 households.

Clupeiformes, such as sardines and herrings, represent an important share of worldwide fisheries. Among those, the European sardine (Sardina pilchardus, Walbaum 1792) exhibits significant commercial relevance. While the last decade showed a steady and sharp decline in capture levels, recent advances in culture husbandry represent promising research avenues. Yet, the complete absence of genomic resources from sardine imposes a severe bottleneck to understand its physiological and ecological requirements. We generated 69 Gbp of paired-end reads using Illumina HiSeq X Ten and assembled a draft genome assembly with an N50 scaffold length of 25579 bp and BUSCO completeness of 82.1% (Actinopterygii). The estimated size of the genome ranges between 655 and 850 Mb. Additionally, we generated a relatively high-level liver transcriptome. To deliver a proof of principle of the value of this dataset, we established the presence and function of enzymes (elovl2, elovl5 and fads2) that have pivotal roles in the biosynthesis of long chain polyunsaturated fatty acids, essential nutrients particularly abundant in oily fish such as sardines. Our study provides the first omics dataset from a valuable economic marine teleost species, the European sardine, an essential resource for their effective conservation, management and sustainable exploitation.

Markov chain Monte Carlo sampling propagators, including numerical integrators for stochastic dynamics, are central to the calculation of thermodynamic quantities and determination of structure for molecular systems. Efficiency is paramount, and to a great extent, this is determined by the integrated autocorrelation time (IAcT). This quantity varies depending on the observable that is being estimated. It is suggested that it is the maximum of the IAcT over all observables that is the relevant metric. Reviewed here is a method for estimating this quantity. For reversible propagators (which are those that satisfy detailed balance), the maximum IAcT is determined by the spectral gap in the forward transfer operator, but for irreversible propagators, the maximum IAcT can be far less than or greater than what might be inferred from the spectral gap. This is consistent with recent theoretical results (not to mention past practical experience) suggesting that irreversible propagators generally perform better if not much better than reversible ones. Typical irreversible propagators involve a parameter controlling the mix of ballistic and diffusive movement. To gain insight into the effect of the damping parameter for Langevin dynamics, its optimal value is obtained here for a multidimensional quadratic potential energy function.

The involvement of the angiotensin II type 1 receptor in the Frank-Starling Law of the Heart, where the various activations are very limited, allows simple analysis of the kinase systems involved and thence extrapolation of the mechanism to that of angiotensin control of activation of cardiac and skeletal muscle contraction. The involvement of phosphorylation of the myosin light chain in the control of contraction is accepted but not fully understood. The involvement of troponin-I phosphorylation is also indicated but of unknown mechanism. There is no known signal for activation of myosin light chain kinase or Protein Kinase C-βII other than Ca²⁺/calmodulin but the former is constitutively active and thus has to be under control of a regulated inhibitor, the latter kinase may also be the same. Ca²⁺/calmodulin is not activated in Frank-Starling, i.e. there are no diastolic or systolic [Ca²⁺] changes. I suggest here that that the regulated inhibition is by myosin light chain phosphatase and/or β-arrestin. Angiotensin activation is by translocation of the β-arrestin from the sarcoplasm to the PM thus reducing its kinase inhibition action in the sarcoplasm, this reduced inhibition has been wrongly attributed to a mythical downstream agonist property of β-arrestin.

This research investigates the pivotal role of Supplier Relationship Management (SRM) in enhancing e-commerce scalability. SRM practices are essential for optimizing supply chain operations and fostering strategic partnerships with suppliers, crucial in the dynamic and competitive e-commerce landscape. Through a comprehensive analysis of case studies, expert interviews, and secondary data, the study examines how leading e-commerce companies such as Amazon and Alibaba implement effective SRM strategies to achieve scalability. Key findings reveal that strategic supplier selection based on capabilities and alignment with business goals, coupled with continuous evaluation and development programs, ensures consistent supply chain performance and customer satisfaction. Technological advancements, including data analytics, artificial intelligence, and blockchain, play a transformative role in modern SRM by enhancing transparency, efficiency, and decision-making capabilities. These technologies enable real-time monitoring, automated processes, and risk mitigation strategies that bolster supply chain resilience and operational efficiency. Best practices in SRM, such as clear performance metrics, a culture of continuous improvement, and ethical sourcing policies, are critical for driving supplier accountability, innovation, and sustainability. Moreover, sustainability emerges as a growing priority in SRM, with businesses integrating environmental and social considerations into supplier management strategies to meet regulatory requirements and stakeholder expectations. Theoretical frameworks like the Resource-Based View and Transaction Cost Economics provide insights into the strategic implications of SRM, emphasizing its role in fostering competitive advantage and long-term business success. As e-commerce continues to evolve, businesses must adapt and innovate in their SRM approaches to navigate global supply chain complexities effectively. By prioritizing effective SRM practices, leveraging advanced technologies, and embracing sustainability, businesses can enhance their scalability, resilience, and competitiveness in the digital economy.

This study explores the barriers to adopting green supply chain practices from the perspective of industry leaders. By conducting qualitative interviews with key decision-makers in various sectors, the research uncovers the complexities and challenges faced in integrating sustainable practices into supply chain operations. The findings highlight significant obstacles such as cost implications, lack of regulatory support, technological limitations, and resistance to change within organizations. Additionally, the study reveals that while there is a growing awareness and commitment towards sustainability, practical implementation remains fraught with difficulties. The insights gained from industry leaders provide a nuanced understanding of the multifaceted nature of these barriers, offering valuable guidance for businesses and policymakers aiming to promote greener supply chains.

In contemporary marketing and consumer behavior research, supply chain transparency has emerged as a critical determinant of brand image and consumer trust. This qualitative study explores how transparency in supply chain communication shapes brand perception and influences consumer behavior. Through in-depth interviews with marketing professionals, consumers, and supply chain managers, this research examines the impact of transparent practices on consumer trust, brand loyalty, and market differentiation. Findings reveal that transparent disclosure of sourcing, production methods, and sustainability initiatives enhances consumer perception of brand authenticity and ethical responsibility. Effective communication strategies such as detailed product labeling, interactive digital content, and third-party certifications play a pivotal role in educating consumers and reinforcing brand credibility. Despite the benefits, the study identifies challenges including global supply chain complexity, lack of standardized metrics, and economic considerations associated with transparency implementation. Technological advancements like blockchain and data analytics offer solutions to improve supply chain visibility and traceability, supporting brands in meeting ethical standards and consumer expectations. Moreover, transparency facilitates effective crisis management and reputation recovery by enabling brands to promptly address supply chain issues and maintain consumer trust during disruptions. The research highlights cultural and regional variations in consumer expectations regarding transparency, underscoring the need for brands to tailor communication strategies to local values and preferences. As brands navigate these complexities, prioritizing transparency not only strengthens consumer relationships but also positions them as leaders in ethical business practices. Ultimately, this study contributes to understanding the strategic importance of supply chain transparency in fostering sustainable brand growth and resilience in a competitive global market.

The abstract of the study on the challenges and opportunities of supply chain digitalization encapsulates the primary findings and their implications from the perspectives of industry leaders. This qualitative research investigated how senior executives across diverse sectors perceive and manage the transition to digital supply chains. Interviews with twenty industry leaders revealed key challenges such as data integration, cybersecurity, organizational resistance, and financial constraints. Data integration issues were particularly pronounced, as participants struggled with unifying disparate data sources from legacy and modern systems, creating barriers to achieving cohesive digital frameworks. Cybersecurity emerged as a critical concern due to the increased vulnerability of digital supply chains to cyber threats, necessitating robust and proactive security measures. Organizational resistance, driven by employee apprehensions about job displacement and technological unfamiliarity, highlighted the need for effective change management practices, including clear communication and training. Financial constraints, especially for small and medium-sized enterprises (SMEs), underscored the difficulty of justifying the substantial investments required for advanced digital technologies. Despite these challenges, the study identified significant opportunities associated with digitalization, including enhanced operational efficiency, improved visibility, predictive analytics, and better customer satisfaction. Digital tools were found to streamline processes, reduce manual intervention, and provide real-time insights into supply chain performance, thus facilitating more informed decision-making and swift responses to disruptions. The accelerated adoption of digital technologies during the COVID-19 pandemic demonstrated their essential role in enhancing supply chain resilience and agility. Additionally, the integration of sustainability goals through digitalization supported resource optimization and waste reduction, aligning with broader corporate social responsibility objectives. The findings suggest that while the path to digital transformation is complex, the benefits of improved efficiency, decision-making, customer satisfaction, and sustainability present compelling incentives for organizations to invest in and embrace digital supply chain solutions.

This study investigates the pivotal role of leadership in driving sustainable supply chain initiatives (SSCI), highlighting the multifaceted ways through which leaders influence the successful integration and implementation of sustainability practices within supply chains. Using a qualitative approach, the research involved semi-structured interviews with leaders and managers from diverse industries, complemented by document analysis and thematic analysis to capture the complexities of leadership in SSCI. The findings reveal that visionary leadership, characterized by a clear and compelling sustainability vision, plays a crucial role in aligning organizational goals with sustainable practices, inspiring collective action, and fostering a shared commitment to long-term environmental and social objectives. Stakeholder engagement emerged as a critical factor, with leaders who prioritize open communication and collaboration successfully building trust, leveraging expertise, and co-creating innovative solutions to sustainability challenges. Additionally, the study highlights the importance of fostering a culture of innovation, where leaders support experimentation, risk-taking, and the adoption of new technologies and processes that enhance sustainability. Ethical leadership, emphasizing integrity, transparency, and accountability, is identified as essential for gaining stakeholder support and reinforcing the legitimacy of SSCI. Furthermore, the integration of sustainability into organizational culture, driven by leadership, is crucial for aligning individual and organizational behaviors with sustainability goals. The ability of leaders to navigate challenges, adapt to global supply chain complexities, and utilize robust sustainability metrics is also emphasized as key to sustaining SSCI. The study concludes that effective leadership is integral to the success of SSCI, offering valuable insights for organizations aiming to enhance their sustainability performance and contributing to the broader understanding of leadership’s role in sustainable supply chain management.

This study investigates the impact of integrated marketing strategies on supply chain efficiency in retail businesses. Through qualitative research methods including in-depth interviews and case studies, the study explores how aligning marketing activities with supply chain operations influences various aspects of retail performance. The findings reveal that integrated marketing strategies lead to enhanced demand forecasting accuracy, improved customer satisfaction, and greater operational efficiency. By leveraging technology, such as artificial intelligence and data analytics, retailers can optimize inventory management, personalize offerings, and anticipate consumer preferences in real-time. Cross-functional collaboration and effective leadership emerge as crucial factors in fostering integration and overcoming challenges such as data management and cultural resistance. Additionally, the study highlights the significance of sustainability and entrepreneurship in driving integrated strategies, with implications for long-term competitiveness and brand reputation. The findings underscore the importance of viewing marketing and supply chain functions as interconnected elements of a holistic business strategy, rather than operating in silos. The study offers valuable insights for theory, practice, and future research, emphasizing the need for holistic and collaborative approaches to integration in the dynamic retail landscape. By embracing integrated marketing strategies, retailers can position themselves for success in an increasingly competitive market environment, driving innovation, efficiency, and customer satisfaction.

E-waste management (EWM) refers to the operation-management of discarded or unproductive electronic devices and components, a challenge exacerbated due to overindulgent urbanization. This article presents a multidimensional cost-function-based analysis of the EWM framework structured on three modules - environmental, economic, and social uncertainties - which contemplate the 3 pillars of sustainability in an e-waste recycling plant, including the production-delivery-utilization process. The framework incorporates material recovery from a single e-waste facility provisioning for chemical and mechanical recycling. Each module is ranked using independent Machine Learning (ML) protocols: a) Analytical Hierarchical Process (AHP) and b) combined AHP and Principal Component Analysis (PCA). From a long list of possible contributors, the model identifies and ranks two key sustainability contributors to the EWM supply chain: overall energy consumption and volume of carbon dioxide generated. Another key finding is a precise time window for policy resurrection, which for the data considered, happens to be 400-600 days from the start of operation. Another interesting outcome is the quality of prediction using a combination of AHP and PCA, which consistently produced better results than any of these ML methods individually implemented. Model outcomes have been verified using a case study to outline a future E-waste sustained roadmap.

This paper reviews the pioneering work related to the generation of a sequence of prompts in Pretrained Language Models (PLMs) to automatically complete a complex writing task. The paper identifies the main categories of automated multi-step prompting and discusses their advantages and disadvantages. The paper also proposes an additional approach for automated multi-step prompting with iterative four main phases: in the first phase a sequence of prompts is geared to elicit the structure of the requested task. This is done by identifying the task’s main parts, the general contents of the different parts and their precedence relations. The structure of each main part is iteratively explored to find secondary and tertiary parts if they exist. A second phase is followed by a sequence of prompts that fill in the primary, secondary, and tertiary parts, and seek to fine-tune the result. The third phase reviews the generated text and criticizes it. Based on this criticism a revision is prepared. The fourth phase is fine-tuning the document, with emphasis on section length and text tone. Future research could deal with the system identification of points where the system should initiate interaction with the user for desired feedback and guidance.

Nuclear DNA mutations, mitochondrial DNA mutations, combined nuclear and mitochondrial DNA defects, and random occurrences are the main causes of mitochondrial disease. Black pigmentation loss is a major sign of Parkinsonism. Because of the loss of dopaminergic neurons in the substantia nigra, it drops to less than 80%. The degree of motor impairment was correlated with the amount of black pigmentation loss. After RNA extraction, reverse transcription is carried out because reverse transcriptase was used to create cDNA. One microliter of total RNA supplemented with IORT Buffer, dNTPs, random hexamers, Multi-Scribe Reverse Transcriptase, and nuclease-free was used to create cDNA. The following was how the reaction was carried out in a thermal cycler: 10 minutes at 25°C, 120 minutes at 37°C, 5 seconds at 85°C, and lastly 4°C. The data was expressed as a v-value, which shows how much the target gene is enriched in comparison to the reference gene. Earlier research using mice injected with functional HtrA2/Omi protease activity revealed similar outcomes, including induced up-regulation of CHOP, decreased mitochondrial function, and early brain cell aging because of an increase in mtDNA deletions. The cell viability of the genotypes exhibits a dmg concentration-dependent effect in these results, suggesting that high content ratios of drug treatment with 6-OHDA may be the cause of cellular content depletion. After 6-OHDA neurotoxin treatment, CHOP is up-regulated. Prior in vitro research has shown that treatment with a model based on 6-OHDA neurotoxin causes the activation of mitochondrial stress pathways, which in turn promotes the death of neurons. 6-OHDA reversibly inhibited complexes I and IV's activities in rat brain cells, which led to dopaminergic neurodegeneration, a defining feature of PD pathogens. As a result, the number of living cells will directly correlate with the dmg concentration, supporting the results of the current study. Real-time PCR can generally demonstrate that the removal of HtrA 2 results in a significant up-regulation of Hsp60 expression when compared to WT cells. This could be linked to a decreased threshold for mitochondrial stress in HtrA2 KO cells, which would explain why, following ADEP4 and ACP5 treatment, Hsp60 is significantly up-regulated in HtrA2 KO cells compared to WT cells.

This study presents a critical literature review on the models of users' adoption of blockchain applications in supply chains. This review pertaining to blockchain technology adoption by supply chain stakeholders is significant as it is a pre-requisite for the technical sustainability of blockchain technology in supply chains. Through a critical literature review, the previous studies related to technology adoption models were analyzed to explore practices brought about by blockchain applications for supply chain management. This study examined the suitability of the existing models (e.g., the technology-organization-environment (TOE) framework, task technology fit (TTF), unified theory of acceptance and use of technology (UTAUT)) of technology adoption for blockchain applications in supply chains and came up with a new unified model, namely, TOE-TTF-UTAUT. This review provides implications for a more appropriate research design using mixed methods. When adopting the TOE-TTF-UTAUT model in a study, two phases of research using mixed methods can be performed. The first phase is an exploratory sequential design in which a qualitative approach to explore the TOE and supply chain task constructs is followed by a quantitative approach using a survey and quantitative analyses to investigate the factors affecting blockchain adoption in supply chains. The second phase adopts explanatory sequential design in which the quantitative findings from the first phase are reviewed for follow-up by qualitative interviews to obtain explanations.

In this study, a commercial sodium butyrate protected by a new buffer salt solution (NSB) was tested to determine whether it can be used as an antibiotic alternative in broiler production. 192 1-day-old broilers were randomly allocated to three dietary treatments: soybean meal diet (CON), antibiotic diet (ANT, basal diet + 100 mg/kg aureomycin), and NSB (basal diet + 800 mg/kg NSB). The growth performance, serum anti-inflammatory cytokines, intestinal morphology, gut barrier function, antioxidative parameters, SCFAs content, and cecal microbiota were analyzed. The result showed that NSB significantly improved ADFI, ADG (p < 0.01), and decreased FCR (p < 0.01). Serum anti-inflammatory cytokine IL-10 was up-regulated (p < 0.01), and pro-inflammatory TNF-α was down-regulated (p < 0.05) by NSB supplementation. H&E results showed that VH and VH: CD ratio significantly increased (p < 0.05) in the jejunum and ileum in the NSB group. Furthermore, ZO-1 (p < 0.01), claudin-1 (p < 0.01), and occludin (p < 0.05) in the jejunum and claudin-1 (p < 0.01) and mucin-2 (p < 0.05) in the ileum significantly up-regulated in the NSB group, respectively. Additionally, SOD (p < 0.05) and T-AOC/MDA ratio (p < 0.01) in the jejunum and SOD in the ileum were significantly increased (p < 0.05) in the NSB group. The MDA level also significantly increased (p < 0.01) in the ANT group in the jejunum. Propionic acid (p < 0.05) and butyric acid (p < 0.01) content significantly increased in the NSB group in the jejunum and ileum segments. The 16S rRNA sequencing results showed no significant difference (p > 0.05) in alpha and beta diversity among the groups. LEFSe analysis also indicated that Peptostreptococcaceae, Colidextribacter, Firmicutes, Oscillospira, and Erysipelatoclostridiaceae, which promote SCFA production (p < 0.05), were identified as dominant taxon-enriched bacterial genera in the NSB group. The Spearman correlation analysis revealed that Colidextribacter with ADFI, ADG, VH, claudin-1 (p < 0.05), and unclassified_f__Peptostreptococcaceae with ADFI, IL-10, and ZO-1 were positively correlated (p < 0.05). Furthermore, ADFI and ADG with IL-10, claudin-1, SOD, T-AOC, and butyric acid (p < 0.05), and similarly, ADG with VH (p < 0.05) showed a positive correlation. In conclusion, NSB enhanced the growth performance by improving jejunum and ileum morphology, serum anti-inflammatory cytokines, regulating intestinal barrier function and antioxidant capacity, SCFAs content, and cecum microbiota, showing its potential use as an alternative to antibiotics in poultry nutrition.

As a widely used plastic, the aging and degradation of polyethylene (PE) are inevitable problems, whether the goal is to prolong the life of PE products or address the issue of white pollution. Molecular simulation is a vital scientific tool in elucidating the mechanisms and processes of chemical reactions. To obtain the distribution and evolution process of PE's thermal oxidation products, this work employs the self-consistent charge density functional tight binding (SCC-DFTB) method to perform molecular simulations of the thermal oxidation of PE with different crystallinity and branched structures. We discovered that crystallinity does not affect the thermal oxidation mechanism of PE, but higher crystallinity makes PE more susceptible to cross-linking and carbon chain growth, reducing the degree of PE carbon chain breakage. The branched structure of PE results in differences in pore size between the carbon chains, with larger pores leading to a concentrated distribution of O2 and free radicals subsequently formed. The breakdown of PE is slowed down when free radicals are localized in low-density regions of the carbon chain. The specifics and mechanism of PE's thermal oxidation are clearly revealed in this paper, which is essential for understanding the process in-depth and for the development of anti-aging PE products.

Skeletal muscles are crucial for voluntary movements, and impairments in their function significantly impact our activity. Dysferlin, a protein predominantly present in skeletal muscle, is a focal point of extensive research due to its vital role in muscle repair and maintenance. This study investigates Dysferlin's levels and function in skeletal muscles, emphasizing its significance and the potential effects of its dysregulation on fast and slow muscle fibers. We employed Western blotting on two different rat muscles. The results revealed distinct expressions of Dysferlin in fast and slow fibers, as demonstrated by Western blotting. We propose that Dysferlin may have a metabolic role in addition to its involvement in the repair mechanism.

Environmental responsibility and economic benefits have promoted the development of closed-loop supply chain (CLSC), and shortages and channels are considered to be two important issues in CLSC. This paper explores ordering and channel decisions in CLSC with new and differentiated remanufactured products, and considers the price and sales effort-dependent demands, as well as the proportion of emergency orders determined by emergency order costs and backorder losses, and establishes an integrated and decentralized CLSC game models. We introduce a stochastic sales effort, which affects two types of products. Numerical results show that sales effort and the order quantity of new and remanufactured products exhibit concave and convex functions, respectively. Wherein, the upper limit of sales effort has a greater impact on supply chain decisions. High sales efforts can serve as a means of coordinating dispersed supply chains. Moreover, in different cases, decisions of integrated channel are better than those of decentralized channel. Finally, whether the supply chain adopts an emergency order strategy depends on the relative cost of emergency orders and out of stock costs. According to the research in this article, some management insights are also provided.

The overhead squat movement engages various bodily structures, and its interaction with three-dimensional elastic resistance along the kinetic chain approach remains insufficiently comprehended. This study aimed to describe the scapular kinematics during an overhead squat with the forearm in a supination exercise against an ER and clarify the therapeutic potential of this exercise on scapular rehabilitation. Using an electromagnetic tracking system, we recorded the three-dimensional shoulder kinematics of 19 male participants across seven humeral elevation positions. These positions were captured at 15-degree intervals, spanning from 30 to 120 degrees. The results indicated notable distinctions in scapular upward rotation [F(1,17)=6.09, p=0.024] and scapular posterior tilt [F(1,17)=6.04, p=0.025] between the phases. Furthermore, the interactions revealed significant differences in resistance and phases during humeral elevation for scapular upward/downward rotation [F(3.77,62.48)=7.99, p&lt;0.001], scapular internal/external rotation [F(2.98, 50.64, p&lt;0.001)], and scapular tilt [F(2.58, 43.81)=4.76, p=0.008]. The findings demonstrated that increasing resistance through elastic resistance played a pivotal role in enhancing scapular stability throughout the humerus elevation motion. This underscores the potential of the overhead squat movement as a valuable tool for both shoulder assessment and treatment.

A The guinea pig value chain in Jauja, Peru, has been developed through the application of productive projects, institutional strengthening and implementation of the principles of responsible investment in agriculture and food systems (CFS-RAI). The actors in this chain have been showing economic improvements, representativeness and participation, characteristics that make them the key human capital for development. To improve the performance of the actors in the sustainable rural development of the territory of Jauja, Peru, the research carried out an evaluation of the competencies and capacities for project management in 46 actors linked to the business programme on the CFS-RAI Principles, representing 1,094 people in the guinea pig value chain in Jauja, using the Working With People (WWP) model and empirical instruments based on the Octagon method, International Project Management Association (IPMA) competencies, performance evaluation carried out by experts, attitudinal evaluation and the Business Model Canvas. The results have helped to structure the actors of the value chain, who show an intermediate mastery of project management competencies (2.73/5), institutional capacities in development (2.89/7) and a growing organizational management performance (26.2/100). In addition, trust and proactivity have been generated among the actors in the chain, with an interest in continuing with the implementation of the CFS-RAI Principles in order to achieve sustainability in their productive projects with commercial innovation. The results have allowed us to generate the design of an innovative programme for the development of competencies, which balances the three dimensions of IPMA competencies (perspective, person and practice) in connection with the CFS-RAI Principles. Both processes complement the strengthening of human capital in agrifood value chains through sustainable project management and contributing to sustainable development in the region.

This study takes a two-echelon agricultural products supply chain (APSC) composed of an agricultural product processor (processor) and an agricultural product supermarket (supermarket) as the research object. In order to ensure the stable supply of high-quality agricultural products, this paper considers both fairness concern and corporate social responsibility (CSR), and establishes four Stackelberg game models with or without considering fairness concern and CSR, and obtains the influence mechanism of fairness concern and CSR on bilateral quality efforts in APSC through comparative analysis and numerical analysis. Research shows that the supermarket’s fairness concern can take the role of "profit distribution mechanism", but it is not conducive to improving bilateral quality efforts resulting in the inability to improve market demand, and it is not conducive to improving the utility of the supply chain system and consumer surplus; both members of APSC sharing CSR can not only improve the quality of agricultural products and promote the expansion of market demand, but also can achieve Pareto improvement of both profit of all members and supply chain system. Besides, The CSR shared by both members has a greater impact on bilateral quality efforts decision than the supermarket’s fairness concern, and thus the positive effect of CSR can overcome the negative effect of supermarket’s fairness concern.

Polymerase chain reaction (PCR) technique is one of the molecular methods in amplifying DNA for the detection of malaria. However, the limitations of PCR especially when used for routine clinical practice can hamper its sensitivity and specificity. With that, this study focuses on designing a microfluidic device that will mimic the function of a conventional genus-specific PCR based on 18S rRNA gene to detect malaria parasites (Plasmodium falciparum) at low grade parasitemia. The design was drawn and simulated using ANSYS 14.5 Computational Fluid Dynamics (CFD). The simulation shows that adding loops to the design increases its relative deviation but to a minimal extent as compared to having only a straight path design, which indicates that looping is acceptable in designing a microfluidic device to minimize chip length. Also, increasing the cross-sectional area of the fluid path decreases the efficiency of the design, thus, the design with a relatively smaller cross-sectional area is favored. And lastly, among the three materials utilized, the chip made of polypropylene is the most efficient with a relative deviation of 0.94 as compared to polycarbonate and polydimethylsiloxane which have relative deviations of 2.78 and 1.92, respectively.

Supply Chain Management (SCM) encompasses a wide variety of decision-making problems that affect business and supply chain performance as a whole. Since most of these problems involve uncertainty and hesitation on the part of Decision Makers (DMs), various studies have emerged recently that present SCM applications of techniques based on Hesitant Fuzzy Linguistic Term Sets (HFLTSs) and HFLTS extensions. Given the relevance of this subject and the lack of literature review studies, this study presents a systematic review of HFLTS and HFLTS extension applications to SCM decision-making problems. In order to answer a set of research questions, the selected papers have been classified in accordance with a group of factors that are pertinent to the origins of these studies, SCM, HFLTSs, and decision-making. The results demonstrate that the Source and Enable processes have been studied with greater frequency, while the most common problems have to do with supplier selection, failure evaluation, and performance evaluation. The companies of the automotive sector and Sustainable SCM and Green SCM strategies predominate in the analyzed studies. Even though most of the studies use techniques based on HFLTSs, we have identified applications of seven distinct HFLTS extensions, with Double Hierarchy Hesitant Fuzzy Linguistic Term Sets and Probabilistic Linguistic Term Sets being the most utilized. The identification of gaps in the literature presents avenues for future studies focused on innovative applications, integrations of techniques, comparisons of techniques, group decision-making, and validation procedures for new models. The results of this study offer a panorama of the state of the art in regard to this subject and can help researchers and practitioners develop new studies which involve the use of methods that employ HFLTSs and HFLTS extensions in SCM decision-making problems.

Plant flavonoids have increasingly paid a close attention to for new antimicrobial agents or adjuvants. In our previous work, it was confirmed that the cell membrane is the major site of plant flavonoids acting on the gram-positive bacteria, and which likely involves the inhibition of the respiratory chain. Inspired by the similar structural and antioxidant characters of plant flavonoids to MKH₂, we deduced that the quinone pool is probably a key target of plant flavonoids inhibiting gram-positive bacteria. To verify this, twelve plant flavonoids with six structural subtypes were preliminary selected, and their MICs against gram-positive bacteria were predicted from the antimicrobial quantitative relationship of plant flavonoids to gram-positive bacteria. The results showed they have different antimicrobial activities. After their MICs against S. aureus were determined using broth microdilution method, nine compounds with the MICs ranged from 2 to 4,096 μg/mL or more than 1,024 μg/mL were eventually selected, and then their MICs against S. aureus were determined interfered with different concentrations of MK-4 and the MKs extracted from S. aureus. The results showed that the greater the antibacterial activities of plant flavonoids were, the more greatly their antibacterial activities decreased along with the increase of the interfering concentrations of MK-4 (from 2 to 256 μg/mL) and MK extract (from 4 to 512 μg/mL), and while those, with the MICs equal to or more than 512 μg/mL, decreased a little or remained unchanged. Especially, under the interference of MK-4 (256 μg/mL) and MK extract (512 μg/mL), the MICs of α-mangostin, a compound with greatest inhibitory activity to S. aureus in these twelve plant flavonoids, increased by 16 times and 8 to16 times, respectively. Based on these above, it was proposed that the quinone pool is a key target of plant flavonoids inhibiting gram-positive bacteria, and which likely involves multiple mechanisms including some enzyme and non-enzyme inhibitions.

With the continuous growth of electric and electronic appliances’ usage, the waste produced with obsolete material (e-waste) has an increasing environmental impact. Also, the production of such appliances bears to increased consumption of natural resources and produces a multitude of toxic and hazardous substances, which typically are not properly treated. One of the approaches that may be adopted to reduce such problems relies on the circularization of the current linear model, commonly adopted in the EEE value chain. This includes recovering eol products and reintroducing its parts, components, or raw materials into the value chain (e.g. semiconductors, circuit boards, raw metals, etc.), thus contributing to a more sustainable value chain. In this article, we present a state-of-art review that focuses on approaches and solutions for the EEE value chain traceability, and analyses the technologies that may be beneficial for promoting and implementing the CE model in this value chain.

The opioid crisis in the United States has had devastating effects on communities across the country, leading many states to pass legislation that limits the prescription of opioid medications in an effort to reduce the number of overdose deaths. This study evaluates the impact of two categories of PDMP and Pill Mill regulations on the supply of opioid prescriptions at the level of dispensers and distributors (excluding manufacturers) using ARCOS data. The study uses a difference-in-difference method with a two-way fixed design to analyze the data. The study finds that both of the regulations are associated with reductions in the volume of opioid distribution. However, the study reveals that these regulations may have unintended consequences, such as shifting the distribution of controlled substances to neighboring states. For example, in Tennessee, the implementation of Operational PDMP regulations reduces in-state distribution of opioid drugs by 3.36% (95% CI, 2.37 to 4.3), while the out-of-state distribution to Georgia, which did not have effective PDMP regulations in place, increases by 16.93% (95% CI, 16.42 to 17.44). Our studies emphasize that policymakers should consider the potential for unintended distribution shifts of opioid drugs to neighboring states with laxer regulations as well as varying impacts on different dispenser types.

Non-timber forest products (NTFP) have contributed in various ways to the living, livelihoods, and trading of households and communities who live in rural and urban areas all over the world. This paper analyses the value chain of Jiaogulan (Gynostemma pentaphyllum) in the Cao Bang Geopark, Vietnam. 106 actors were surveyed using a semi-structured questionnaire: experts (agricultural extension officers, farmers' associations), harvesters, traders, primary processors, processors, distributors, and consumers. The results show that a map of Jiaogulan value chain, value added of households in main market channels, and impact of value added and distribution of Jiaogulan products on household income.

The Impact Chain framework for risk assessment has proven to be a robust and effective It is very useful to set up the conceptual framework associated to a given risk and allows accommodating naturally the different components that shape that However, the operationalization of the impact chain may not be straightforward, in particular due to the inherent uncertainties associated to the selected indicators and the assigned In this paper, we introduce an extension to the Impact Chain framework that allows to consider uncertainties in the different components of the risk In the framework of the UNCHAIN project, a web-based tool has been developed to ease the task of implementing that The tool has been applied to a case study on the loss of tourist attractiveness due to heat stress conditions on the Balearic island, Spain, to illustrate how uncertainties in different components of the impact chain can affect the robustness of the final risk Also, the tool provides an estimate of the sensitivity of the final risk to each component, which can be used to guide risk mitigation Finally, a proposal for the validation of the risk assessment is presented.

Background: Wolbachia sp. is an endosymbiotic bacterium that is widespread among arthropods and filarial nematodes. It affects the fertility and maturation of its arthropod hosts, which in some cases are vectors of infectious diseases of humans and animals. Acanthocheilonema reconditum is a canine filarial nematode, which can eventually infect humans through arthropods. An outbreak of A. reconditum has been reported recently in dogs in the southwest of Colombia, specifically in Cali. In addition, Wolbachia sp. is currently used for the biological control of the mosquito Aedes egypti in cities in the north and south-west of Colombia. Aedes egypti is a vector of dengue fever, a major public health disease in tropical and subtropical areas of the world. The objectives of this study were to detect Wolbachia sp. in mosquito and flea samples collected from dogs in southwestern Colombia and to determine the co-infection of Wolbachia sp. and A. reconditum in the recent outbreak of canine filariasis in Santiago de Cali. Methods: A total of 18 mosquitoes of the genera Aedes and Culex and 18 Ctenocephalides felis fleas were collected in Santiago de Cali and nearby municipalities. DNA was extracted and 16S rRNA and ftsZ gene fragments were identified using conventional and nested polymerase chain reaction. In addition, the presence of Wolbachia sp. was analyzed in 55 cases positive for A. reconditum previously detected in the city, using the same molecular techniques. Results: From the analysis of 18 mosquitoes and 18 fleas, using molecular techniques based on the 16S rRNA and ftsZ genes, Wolbachia sp. was detected in all the arthropods analyzed. Wolbachia sp. was not detected in the samples obtained from dogs infected with A. reconditum. Conclusions: Molecular analyses were shown to be effective for the identification of Wolbachia sp. in mosquitoes and fleas but not in samples positive for A. reconditum.

Seismic travel time tomography using surface waves is an effective tool for three-dimensional crustal imaging. Historically, these surface waves are the result of active seismic sources or earthquakes. More recently, however, also surface waves retrieved through the application of seismic interferometry are exploited. Conventionally, two-step inversion algorithms are employed to solve the tomographic inverse problem. That is, a first inversion results in frequency-dependent, two-dimensional maps of phase velocity, which then serve as input for a series of independent, one-dimensional frequency-to-depth inversions. As such, a two-dimensional grid of localized depth-dependent velocity profiles are obtained. Stitching these separate profiles together subsequently yields a three-dimensional velocity model. Relatively recently, a one-step three-dimensional non-linear tomographic algorithm has been proposed. The algorithm is rooted in a Bayesian framework using Markov chains with reversible jumps, and is referred to as transdimensional tomography. Specifically, the three-dimensional velocity field is parameterized by means of a polyhedral Voronoi tessellation. In this study, we investigate the potential of this algorithm for the purpose of recovering the three-dimensional surface-wave-velocity structure from ambient noise recorded on and around the Reykjanes Peninsula, southwest Iceland. To that end, we design a number of synthetic tests that take into account the station configuration of the Reykjanes seismic network. We find that the algorithm is able to recover the 3D velocity structure at various scales in areas where station density is high. In addition, we find that the standard deviation on the recovered velocities is low in those regions. At the same time, the velocity structure is less well recovered in parts of the peninsula sampled by fewer stations. This implies that the algorithm successfully adapts model resolution to the density of rays. Also, it adapts model resolution to the amount of noise on the travel times. Because the algorithm is computationally demanding, we modify the algorithm such that computational costs are reduced while sufficiently preserving non-linearity. We conclude that the algorithm can now be applied adequately to travel times extracted from (time-averaged) station-station cross correlations by the Reykjanes seismic network.

The conformational preferences of the ester group have the potential to facilitate the large amplitude folding of long alkyl chains in the gas phase. They are monitored by Raman spectroscopy in supersonic jet expansions for the model system methyl butanoate, after establishing a quantitative relationship to quantum-chemical predictions for methyl methanoate. This requires a careful analysis of experimental details, and a simulation of the rovibrational contours for near-symmetric top molecules. The technique is shown to be complementary to microwave spectroscopy in quantifying coexisting conformations. It confirms that a C-O-C(=O)-C-C chain segment can be collapsed into a single all-trans conformation by collisional cooling, whereas alkyl chain isomerism beyond this five-membered chain largely survives the jet expansion. This sets the stage for the investigation of linear alkyl alkanoates in terms of dispersion-induced stretched-chain to hairpin transitions by Raman spectroscopy.

Traditional travel agencies and tour operators are recognized as relevant stakeholders in the tourism distribution chain, even though their role as transforming agents in the achievement of more sustainable tourism is beginning to be accepted. This document collects the main topics and the most recent approaches from the academic literature in its analysis of Corporate Social Responsibility (CSR) practices developed by these intermediaries. The work has been structured around six recurring themes in most of the studies carried out: the new intermediaries that operate on the Internet; the role of travel agencies and tour operators in tourism sustainability; the influence of the size of the company; CSR as a disruptive innovation in this sector; the potential of the sustainable tourism supply chain; and the motivations and attitudes of the managers of these businesses when they engage with responsibility. This last topic is developed in greater detail since it is closely linked to the previous ones and dictates in most cases the meaning and function of the sustainable performance.

China is one of the world’s most important countries for waterfowl because of the large amount of potential habitat and its position along major migratory routes. Waterfowl poaching in China is a serious threat, and for over twenty years colleagues and I have tracked waterfowl poaching in China including hunting methods, trade routes and prices involved. According to the latest survey of a NGO, 11.8% of Chinese people have participated in wildlife consumption, and about 32.0% of people have seen wildlife consumption (Not necessarily involved in killing and eating the wildlife). The survey results come from 100 000 internet questionnaires. The current report provides an update focusing on waterfowl poaching in Xinjiang Province of the northwest China, where is highly pathogenic area on the avian influenza, SARS and the Wuhan coronavirus pneumonia (such as COVID-19). The cases in 2011, 2012, and 2014 involved about 1816 to 2760 birds of more than 20 species, with an estimated total of 200 000 wild birds being hunted by a group per year in Xinjiang. Strangely, the poacher was not punished by any law. We know a few waterfowl species are protected as a list of Key Protected Species in China, and hopefully this report will draw attention to the scope of waterfowl poaching in China. China has made great progress with protecting other wildlife, and hopefully more can be done to protect migrating waterfowl.

The purpose of this paper is to explore which financial performance indicators (FPIs) evaluate the level of supply chain capability (SCC) that explicitly touches all of the business functions and processes within and beyond the company. The authors investigated nine FPIs that were selected from the financial statements of 155 companies within nine industries. The authors find that suitable FPIs to measure SCC for shareholders’ value are return-on-assets (ROA), days-sales-outstanding (DSO), and current ratio (CR). This means that higher ROA, shortened DSO, and an appropriate level of CR could reach a sustainable supply chain. These results will help the industry to avert a major disruption in supply chain processes and activities using suitable financial performance indicators.

This paper investigates the contribution of business model innovations in improvement of food supply chains. Through a systematic literature review, the notable business model innovations in the food industry are identified, surveyed, and evaluated. Findings reveal that the innovations in value proposition, value creation processes, and value delivery processes of business models are the successful strategies proposed in food industry. It is further disclosed that rural female entrepreneurs, social movements, and also urban conditions are the most important driving forces inducing the farmers to reconsider their business models. In addition, the new technologies and environmental factors are the secondary contributors in business model innovation for the food processors. It is concluded that digitalization has disruptively changed the food distributors models. E-commerce models and internet of things are reported as the essential factors imposing the retailers to innovate their business models. Furthermore, the consumption demand and the product quality are two main factors affecting the business models of all the firms operating in the food supply chain regardless of their positions in the chain. The findings of the current study provide an insight into the food industry to design a sustainable business model to bridge the gap between food supply and food demand.

Blockchain is a data management innovation that allows the linkage of successive records regarding a digital entity, and to store them into a shared, decentralized, distributed and retroactively unchangeable data structure. Each bit of information related to the recorded events contains the public key of the owner, therefore, the whole record is formed by a chain of transactions with blocks of information identifying where the transaction was generated from and its current destination (Nakamoto, 2008). Blockchain is the technology behind Bitcoin, an online currency that was first introduced in 2009. The technology makes it possible to conduct business between members within the network without relying on third parties as guarantors to prove transaction integrity, thus increasing speed and reducing cost of transaction. Moreover, the transparency posed by the technology makes it possible to trace goods and services through all stages, making the technology a unique tool that can be assimilated by, for example, the Agro-food supply chain systems. Specifically, Blockchain is being tested in a pilot project in the UK meat (Beef) industry by the FSA (Food Standards Agency) and the slaughterhouses, with IBM Blockchain platform to ensure full transparency and compliance with regulations, (Evenstad, 2018). However, the uptake of Blockchain in the fresh produce (fresh and fresh, short-life processed fruit, vegetables, salads) supply chain is lagging, in the United Kingdom, and remains untested and limited to literature, models and specific case studies in the United States of America and France. The study aims at understanding how prepared stakeholders are in adopting Blockchain for their operations. An inductive qualitative method was employed through non-structured interviews with three companies and one consumer focus group. The interviews were guided by seven (7) open-ended questions, which were unstructured. The collected data was analyzed with axial coding through constant comparative methods. Seven (7) themes were identified as factors influencing the adoption of Blockchain in the fresh produce supply chain in the UK. These are, novelty of the technology, complexity of the fresh produce supply chain in UK, level of product transformation, technological compatibility with operations, cost and value, Customer (retailer) push for adoption, and public/consumers opinion. The adaptation of Blockchain by the current fresh produce supply chain in the UK and the EU at large will come about when concerns on Novelty, and complexity of supply chain systems are fully addressed.

Recycling waste products is an environmental-friendly activity that can bring benefits to accompany, saving manufacturing costs and improving economic efficiency. For the beer industry, recycling bottles can reduce manufacturing costs and reduce the industry's carbon footprint. This paper presents a model for a multi-objective collection-distribution center location and allocation problem in a closed loop supply chain for the beer industry, in which the objective is to minimize total costs and transportation pollution. Uncertainties in the form of randomness and fuzziness are jointly handled in this paper to ensure a more practical problem solution, for which returned bottle sand unusable bottles are considered fuzzy random variables. A heuristic algorithm based on priority-based global-local-neighbor particle swarm optimization (pb-glnPSO) is applied to ensure reliable solutions for this NP-hard problem. A case study on a beer operation company is conducted to illustrate the application of the proposed model and demonstrate the priority-based global-local-neighbor particle swarm optimization.

Although, promotion of urbanization culture in recent decades has made inevitable development of cities in the world, however, the development can be guided in a direction that leave, to the extent possible, minimum socioeconomic and environmental impacts. For this, it is required to first forecast auto-spreading orientation of cities and suburbs in rural areas over time and then avoid shapeless growth of cities. This paper is an attempt to develop a dynamic hybrid model based on logistic regression (LR), Markov chain (MC), and cellular automata (CA) for prediction of future urban sprawl in fast-growing cities. The model was developed using 12 widely-used urban development criteria, whose significant coefficient was determined by logistic regression, and validated by relative operating characteristic (ROC) analysis. The validated model was run in Guilan, a tourist province in northern Iran with a very high rate of urban development. For this, changes in the area of urban land use were detected over the period of 1989 to 2013 and then, future sprawl of the province was forecasted by the years 2025 and 2037. The analysis results revealed that the area of urban land use was increased by more than 1.7 % from 36012.5 ha in 1989 to 59754.8 ha in 2013, and the area of Caspian Hyrcanian forestland was reduced by 31628 ha. The results also predicted an alarming increase in the rate of urban development in the province by the years 2025 and 2037, during which urban land use is predicted to develop 0.9 % and 1.38 %, respectively. The development pattern is expected to be uneven and scattered, without following any particular direction. The development will occur close to the existing or newly-formed urban basements as well as around major roads and commercial areas. This development, if not controlled, will lead to the loss of 13863 ha of Hyrcanian forests and if the trend continues, 21013 ha of Hyrcanian forests and 20208 ha of Barren/open lands are expected to be destroyed by the year 2037. In general, the proposed model is an efficient tool for the support of urban planning decisions and facilitates the process of sustainable development of cities by providing decision-makers with an overview on future development of cities where the growth rate is very fast.

This study explores the strategic importance of leveraging supplier relationships for competitive advantage in the e-commerce industry. Strong supplier relationships are crucial for enhancing operational efficiencies, cost management, quality assurance, innovation, sustainability, and overall supply chain resilience. Through collaborative partnerships, e-commerce companies can streamline logistics, reduce costs, ensure consistent product quality, and foster innovation through joint development initiatives. Ethical sourcing and sustainable practices play a pivotal role in supplier relationship management (SRM), aligning with consumer expectations and enhancing brand reputation. Advanced technologies such as AI, blockchain, and IoT further transform SRM practices by improving transparency, efficiency, and decision-making capabilities across the supply chain. The study also discusses challenges in managing global supplier relationships, emphasizing the importance of effective communication, cultural sensitivity, and strategic risk management. By addressing these challenges and nurturing trust-based relationships with suppliers, e-commerce firms can navigate market complexities and achieve sustainable growth. This research provides insights for e-commerce companies seeking to optimize their supplier relationships and maintain competitive advantage in a dynamic market environment.

Supplier diversity initiatives in procurement have emerged as strategic imperatives for organizations aiming to enhance competitiveness and foster socio-economic equity. This research investigates the impact of supplier diversity initiatives across various industries, analyzing implementation strategies, challenges, and outcomes through a mixed-methods approach. Qualitative data, including interviews with procurement professionals and case studies of exemplary organizations, reveal diverse approaches to implementing supplier diversity—from formalized programs with dedicated resources to ad hoc initiatives driven by regulatory compliance or social responsibility goals. Challenges identified include the identification and qualification of diverse suppliers, scalability issues, and internal resistance within procurement teams. Quantitative analysis of survey data highlights positive impacts on organizational performance metrics, such as procurement spend allocation towards diverse suppliers, supplier-driven innovation, and enhanced supply chain resilience. Best practices in successful supplier diversity programs underscore strategic alignment with overall procurement strategies, effective supplier relationship management, and strong leadership commitment. Socio-economic impacts encompass economic inclusion, community engagement, and skills development among diverse supplier networks, contributing to local economic growth and broader social benefits. Despite these benefits, challenges remain in measuring qualitative outcomes and overcoming systemic barriers to implementation. Cultivating an inclusive organizational culture and leveraging leadership support are crucial for sustaining supplier diversity efforts. Continued collaboration and innovation in supplier diversity practices are recommended to maximize benefits and drive meaningful socio-economic impact globally.

Agile procurement has emerged as a transformative strategy for organizations striving to maintain competitiveness in a rapidly evolving marketplace. This qualitative research investigates the implementation, benefits, challenges, and outcomes of agile procurement practices in supply chain management. Through semi-structured interviews and case studies across diverse industries, this study explores how agile procurement enhances organizational adaptability and responsiveness. Key findings reveal that agile procurement enables organizations to swiftly adjust strategies in response to market fluctuations and customer demands, fostering increased customer satisfaction and loyalty. The integration of advanced technologies, including AI and blockchain, facilitates real-time data analysis, optimizing procurement processes and enhancing supply chain efficiency. Organizational culture emerges as a critical factor in successful agile procurement, with leadership support and a collaborative environment driving cultural change towards agility and innovation. Despite its benefits, challenges such as resistance to change and the need for significant technology investments are identified, requiring careful change management and strategic alignment. Case studies illustrate the versatility of agile procurement across sectors, showcasing its role in enhancing operational efficiencies, innovation capabilities, and overall supply chain performance. In conclusion, agile procurement offers organizations a strategic framework to navigate complexities and uncertainties effectively, capitalizing on market opportunities while mitigating risks. Embracing agile principles fosters a resilient organizational culture capable of adapting to dynamic market conditions. Future research should focus on further refining agile procurement strategies to address emerging challenges and sustain competitive advantage in the global marketplace.

This qualitative study explores the transformative role of Supplier Relationship Management (SRM) in the context of e-commerce, focusing on the integration of digital technologies and evolving supplier interactions. As digital advancements such as artificial intelligence, blockchain, data analytics, cloud computing, and the Internet of Things (IoT) reshape traditional SRM practices, e-commerce companies are experiencing significant improvements in efficiency, transparency, and collaboration. This research employs semi-structured interviews, document analysis, and case studies to examine the impact of these technologies on SRM, identify key collaborative practices, and assess risk management strategies. Findings indicate that digital integration enhances decision-making, streamlines operations, and fosters deeper, trust-based supplier relationships. AI facilitates predictive analytics and automates processes, while blockchain provides transparency and reduces fraud. Data analytics supports informed sourcing decisions and risk mitigation, and cloud platforms improve real-time collaboration. IoT enhances supply chain visibility, allowing for better inventory management. Despite these benefits, challenges such as high implementation costs, integration difficulties, data privacy concerns, and security risks remain significant barriers. Collaboration practices, including joint development, shared resources, and coordinated marketing, contribute to innovation and mutual growth, emphasizing the need for effective communication and trust. Risk management strategies, such as scenario planning and supplier diversification, are crucial for maintaining supply chain resilience. Strategic alignment between e-commerce companies and suppliers, including goal congruence and capability matching, is essential for seamless coordination and competitive advantage. The study underscores the importance of a holistic approach to SRM, integrating technology, collaboration, risk management, and strategic alignment to navigate the complexities of supplier relationships in the digital age. These insights provide a framework for e-commerce companies to optimize their SRM practices and achieve sustainable growth in a dynamic marketplace.

This research aims to explore the adoption and impact of green supply chain practices (GSCP) on sustainable development in Bangladesh. The study seeks to understand the current state of GSCP adoption across various industries, identify key drivers and barriers, assess the perceived benefits and challenges, and evaluate the overall impact on environmental sustainability, economic performance, and social well-being. The research employs a qualitative approach, utilizing interviews with key stakeholders, document analysis, and literature review to gather data and insights. Interviews were conducted with representatives from government agencies, businesses, civil society organizations, and academia to obtain diverse perspectives on GSCP adoption and its implications for sustainable development in Bangladesh. The findings reveal a mixed scenario of GSCP adoption across different industries in Bangladesh, with sectors such as textiles leading the way. Key drivers of GSCP adoption include regulatory pressures, market forces, corporate social responsibility initiatives, and financial incentives. However, organizations face significant barriers such as high upfront costs, lack of awareness and expertise, regulatory uncertainty, and supply chain complexity. Despite these challenges, GSCP offer various benefits, including environmental sustainability, economic performance, and social well-being. Successful initiatives demonstrate tangible impacts, highlighting the potential of GSCP to contribute to sustainable development. The research is limited by its qualitative nature and focus on selected industries and stakeholders. Future studies could employ quantitative methods and broader sampling to provide a more comprehensive understanding of GSCP adoption and its implications in Bangladesh. The findings provide actionable insights for policymakers, industry leaders, and other stakeholders to promote GSCP adoption and enhance sustainable development in Bangladesh. Strategies for overcoming barriers and maximizing benefits are outlined, emphasizing the importance of collaboration and capacity-building initiatives. GSCP adoption can have positive social implications by promoting ethical labor practices, improving working conditions, and fostering community engagement. By prioritizing sustainability, businesses can contribute to social well-being and inclusive growth. This research contributes to the literature on GSCP adoption and sustainable development in Bangladesh by providing empirical insights and practical recommendations. The study adds to the understanding of the drivers, barriers, benefits, and challenges associated with GSCP adoption, highlighting the importance of integrating environmental, economic, and social considerations in supply chain management.

The integration of supply chain analytics and Customer Relationship Management (CRM) systems represents a critical strategy for organizations seeking to enhance operational efficiency and customer-centricity in today's competitive business environment. This qualitative study investigates the motivations, strategies, challenges, and outcomes associated with integrating supply chain analytics with CRM systems across diverse industries. Motivations for integration include gaining a unified view of customer data, improving decision-making capabilities, enhancing operational efficiency, and ensuring strategic alignment across organizational functions. Strategies employed by organizations include cross-functional collaboration, investment in scalable technology platforms, and leadership commitment to drive successful integration initiatives. Despite the potential benefits, the integration process presents challenges such as data integration complexities, technical interoperability issues, and organizational resistance to change. Addressing these challenges requires robust technological solutions, effective change management strategies, and a proactive approach to data governance and security. The study identifies significant outcomes from integration efforts, including improved operational efficiency through streamlined processes and optimized resource allocation, enhanced customer insights leading to personalized experiences, and strengthened strategic decision-making supported by real-time analytics.

This study explores the dynamic interplay between supply chain integration and marketing strategies in achieving customer satisfaction. Through a qualitative approach involving semi-structured interviews with supply chain and marketing professionals, the research delves into how these traditionally distinct functions can be aligned to enhance operational efficiency and deliver superior customer experiences. Findings reveal that strategic alignment between supply chain management (SCM) and marketing fosters better coordination of product availability and service delivery, thereby meeting customer expectations consistently and enhancing brand loyalty. Information sharing and technological integration emerge as critical enablers, facilitating real-time data exchange and collaborative decision-making. The study also identifies challenges such as organizational silos, cultural resistance, and technological constraints that impede seamless integration, highlighting the need for proactive strategies to foster cross-functional collaboration. Additionally, the evolving roles of sustainability and customer-centricity are emphasized as key drivers for differentiating brands and achieving competitive advantage. By integrating sustainable practices and adopting a customer-centric approach, organizations can build stronger customer relationships and enhance their market position. The research underscores the importance of leadership support, investment in technology, and a collaborative organizational culture in overcoming integration barriers. The study’s findings provide actionable insights for organizations aiming to optimize their SCM and marketing strategies, drive innovation, and sustain growth in an increasingly complex and competitive business environment. This research contributes to the growing body of knowledge on supply chain and marketing integration, offering practical recommendations for achieving customer satisfaction and long-term success.

This qualitative research investigates the role of collaborative planning in synchronizing supply chain and marketing activities among multinational companies (MNCs). Collaborative planning integrates traditionally separate functions to enhance operational efficiency, customer responsiveness, and strategic alignment. The study employs semi-structured interviews with key informants from diverse MNCs across industries and geographies to explore practices, challenges, and outcomes associated with collaborative planning initiatives. Findings highlight the pivotal role of cross-functional collaboration and advanced technologies, such as artificial intelligence and big data analytics, in improving demand forecasting accuracy, optimizing inventory management, and enabling personalized marketing strategies. Challenges include organizational resistance, cultural barriers, and the complexity of aligning global strategies. Strategic outcomes encompass improved operational efficiency, cost savings, enhanced customer satisfaction, and strengthened competitive advantage. Moreover, the integration of sustainability goals underscores the importance of environmental responsibility and regulatory compliance in collaborative planning frameworks. The study also identifies emerging trends in digital transformation and agile supply chains shaping future practices. Overall, collaborative planning emerges as a strategic imperative for MNCs to navigate complexities, capitalize on opportunities, and sustain growth in a globalized marketplace.

Aligning supply chain and marketing functions is crucial for high-tech startups aiming to successfully launch new products in competitive markets. This qualitative research explores the strategies, challenges, benefits, and best practices associated with supply chain and marketing alignment in high-tech startups. Through a detailed analysis of case studies and semi-structured interviews with industry professionals, the study identifies key insights into how startups can effectively integrate these functions to enhance operational efficiency, market responsiveness, customer satisfaction, and risk management. The findings reveal that successful alignment requires the formation of cross-functional teams, leveraging integrated technologies like CRM and ERP systems, establishing regular inter-departmental communication, and developing joint performance metrics. These strategies foster collaboration and ensure that supply chain and marketing efforts are coordinated towards shared goals. However, startups face challenges such as differing departmental objectives, resource constraints, communication barriers, and technological limitations, which hinder effective alignment. Benefits observed from effective alignment include improved operational efficiency through streamlined processes, enhanced market responsiveness to adapt quickly to changing demands, increased customer satisfaction by delivering products that meet market expectations, and better risk management through proactive identification and mitigation of supply chain and market risks. Best practices identified include fostering a culture of collaboration, investing in technology for data integration and transparency, aligning strategic objectives across functions, and continuously monitoring and adjusting alignment strategies. Integration of broader elements such as sustainability, entrepreneurship, emotional intelligence, marketing, and supplier relationship management further enriches the alignment framework. This study contributes to a deeper understanding of how high-tech startups can strategically align their supply chain and marketing functions to achieve competitive advantage and sustainable growth in dynamic market environments.

This study explores the impact of supply chain visibility (SCV) on marketing strategies within the fast-moving consumer goods (FMCG) industry. In a rapidly evolving market characterized by complex supply chains and dynamic consumer demands, SCV offers a transformative capability by providing real-time data and insights into supply chain operations. Through semi-structured interviews with industry practitioners, the research identifies several key themes: enhanced demand forecasting, increased consumer trust through transparency, improved marketing agility, and the integration of advanced technologies. Findings suggest that SCV significantly improves the accuracy of demand forecasts by providing timely insights into inventory levels, production schedules, and market conditions. This enhanced forecasting aligns supply chain capabilities with marketing efforts, reducing stockouts and optimizing promotional activities. Moreover, SCV fosters consumer trust by enabling transparency regarding product sourcing and ethical practices, which can be effectively communicated in marketing campaigns to build brand loyalty. The agility provided by SCV allows companies to quickly adjust their marketing strategies in response to market disruptions and shifts in consumer preferences, making their campaigns more resilient and responsive. Advanced technologies such as IoT, blockchain, and analytics further enhance the benefits of SCV, providing deeper insights and more sophisticated capabilities for marketing. The study also highlights the importance of cross-functional collaboration between supply chain and marketing teams in leveraging SCV data effectively. Despite challenges such as the need for significant investment and organizational change, the advantages of SCV in enhancing marketing strategies and overall organizational performance are substantial. The research underscores SCV's critical role in shaping effective marketing strategies, offering FMCG companies a path to greater efficiency, agility, and consumer engagement in a competitive landscape.

This study investigates green logistics strategies adopted by businesses to enhance sustainability within their supply chains, particularly focusing on reducing carbon footprints and environmental impacts associated with transportation and distribution activities. Through qualitative analysis and interviews with supply chain managers, industry experts, and sustainability officers, this research provides insights into motivations, strategies, challenges, and benefits related to green logistics practices. Key findings highlight the critical role of aligning green logistics with corporate sustainability goals. Advanced technologies such as telematics, GPS tracking, and data analytics are instrumental in optimizing transportation routes, reducing fuel consumption, and minimizing emissions. Additionally, strategies like using eco-friendly vehicles, energy-efficient warehouse operations, and implementing reverse logistics are identified as effective means to mitigate environmental impacts. Collaboration and partnerships with suppliers, logistics providers, and stakeholders are essential for sharing best practices and fostering joint initiatives. Despite benefits such as cost savings and enhanced corporate reputation, challenges include high initial investments, the absence of standardized metrics for environmental impact, and regulatory complexities. However, regulatory compliance also acts as a driver for green logistics adoption and presents opportunities for improving sustainability performance. The integration of sustainability goals with logistics strategies underscores the interdisciplinary nature of sustainable supply chain management. This holistic approach encompasses aspects of entrepreneurship, emotional intelligence, marketing, and supplier relationship management.

This qualitative study investigates the adoption of Lean Principles in Supply Chain Management (SCM), aiming to explore the motivations, challenges, and outcomes associated with Lean implementation across diverse organizational contexts. Through semi-structured interviews and thematic analysis, insights were gleaned from stakeholders involved in SCM processes, revealing the critical role of organizational culture, leadership commitment, and strategic alignment in driving successful Lean initiatives. The findings underscore the importance of fostering a culture of continuous improvement, where employees are empowered to proactively identify and address inefficiencies. Leadership emerged as pivotal in setting the tone, providing resources, and championing Lean initiatives, while strategic alignment ensured integration with broader organizational goals and objectives. Operational practices and processes were central, highlighting the need for customization and contextual adaptation in Lean implementation. Despite the potential benefits, the outcomes and impact of Lean adoption varied depending on factors such as organizational maturity and industry context. The study also revealed broader cultural and organizational changes catalyzed by Lean adoption, fostering innovation, collaboration, and adaptability. In summary, this study contributes to our understanding of Lean adoption in SCM, offering practical insights for organizations seeking to enhance efficiency and competitiveness in today's dynamic business landscape.

Ethical sourcing practices play a pivotal role in addressing price inflation within renewable energy supply chains. This qualitative research investigates the multifaceted impacts of ethical sourcing, drawing insights from interviews with key stakeholders in the renewable energy sector. The study reveals that ethical sourcing enhances supply chain transparency, traceability, and resilience by mitigating risks associated with unethical practices such as labor exploitation and environmental degradation. Fair trade initiatives contribute to economic stability and reduce price volatility by ensuring fair compensation for producers and workers, fostering long-term relationships, and reinvesting premiums into community development projects. Sustainable sourcing practices align with consumer preferences for eco-friendly products, reduce the demand for virgin resources, and promote regulatory compliance and incentives, thereby stabilizing costs and reducing environmental impact. Socially responsible companies that prioritize fair labor practices and community support experience fewer disruptions and benefit from a more stable and productive workforce. Entrepreneurship and emotional intelligence among leaders drive the adoption and successful implementation of ethical sourcing practices, enhancing brand reputation, consumer trust, and market competitiveness. Despite challenges, such as higher implementation costs and supplier resistance, the long-term benefits of ethical sourcing outweigh the initial costs and contribute to sustainable supply chains. Collaboration, consumer education, and effective regulation are essential for promoting ethical sourcing across the renewable energy sector.

China’s leading development of a complete battery value chain for Electric Vehicles (EV) is restructuring the global automotive sector. The competitive advantage of China's EV battery industry lies on its firms’ core competency and political economic geography. Based on first-hand empirical material and data obtained from years of fieldwork in an EV battery cluster in South China, this paper identifies what the Chinese EV battery industry’s core competency is and details how it is built up from below. The current core competency of Chinese battery firms is their mass manufacturing capability to supply lithium-ion batteries vehicle manufacturers (OEMs) with stable and consistent quality as well as competitive prices. This competency is acquired by firms through technological learning at workshop level while taking use of their experiences accumulated in mass production of batteries for consumer electronics sectors. Furthermore, the rapid learning and accumulation of knowledge on battery manufacturing at large scale is also facilitated by the industrial cluster environment where firms are embedded. Supported and promoted by local government policies, Chinese EV battery clusters are composed of firms from different segments of a complete battery value chain. The findings illuminate the likely strategic strengths, weaknesses, and futures of the Chinese EV battery industry in global competition.

Procurement plays a central and defining role in the efficiency of supply chains. In recent years, the understanding and practice of procurement management have changed significantly due to increasing emphasis on and demand for agility and sustainability within supply chain management systems. Meanwhile, traditional supply chain systems, characterized by siloed processes, limited visibility, and inefficiencies due to manual interventions, can no longer cope with the current dynamic market conditions. Besides, the increasing requirements of sustainability, ethical sourcing, and environmental impact have intensified, making more responsible, transparent, and traceable procurement practices unnegotiable requirements for modern systems. In this paper, we examine the potential of emerging technologies and innovations such as blockchain, artificial intelligence, and the Internet of Things (IoT) in filling these gaps within the supply chain systems of enterprises in the US. The study employs a comprehensive review of relevant literature and case studies to discover and provide insights on how these technologies can improve procurement processes, optimize resource allocation and utilization, and improve sustainability. The findings of this study highlight the need for stakeholders to embrace technological advancements to effectively navigate the dynamic landscape of supply chain management.

This study presents a systematic review of the impact of Industry 4.0, digitalization, and information systems on the procurement function with a focus on the Portuguese reality. Despite global trends emphasizing digital transformation and innovation, the procurement practices in Portugal seem to lag. The adoption of cutting-edge technologies and the comprehensive integration of digital solutions within the procurement and supply chain management sector are yet to materialize fully in the Portuguese SME context. The benefits and obstacles of these technologies in transitioning procurement into a more strategic role are analyzed. By examining existing literature, critical factors for organizations to consider when implementing these technologies and the potential benefits are identified. The results indicate that digitalization has resulted in a data-driven approach to procurement, with the aid of advanced analytics and artificial intelligence for decision-making. Industry 4.0 has facilitated smarter factories, warehouses, and logistics operations with a focus on automation, connectivity, and real-time data. Procurement can more efficiently manage suppliers, track contracts, identify cost-saving opportunities, and increase sustainability with the aid of information systems. The study also highlights potential challenges for organizations. Overall, this study provides insightful findings on the role of digitalization in transforming procurement and the challenges and opportunities that organizations may face.

The only cases where exact distributions of estimates are known is for samples from exponential families, and then only for special functions of the parameters. So statistical inference was traditionally based on the asymptotic normality of estimates. To improve on this we need the {\it Edgeworth expansion} for the distribution of the standardized estimate. This is an expansion in $n^{-1/2}$ about the normal distribution, where $n$ is typically the sample size. The 1st few terms of this expansion were originally given for the special case of a sample mean. In earlier work we derived it for {\it any } standard estimate, hugely expanding its application. We call an estimate $\hat{w}$ of an unknown vector $w\in R^p$, a {\it standard estimate}, if $E\ \hat{w}\rightarrow w$ as $n\rightarrow \infty$, and for $r\geq 1$ the $r$th order cumulants of $\hat{w}$ have magnitude $n^{1-r}$ and can be expanded in $n^{-1}.$ Here we give another huge extension. We give the expansion of the distribution of {\it any smooth function} of $\hat{w}$, say $t(\hat{w})\in R^q,$ giving its distribution to $n^{-5/2}$. We do this by showing that $t(\hat{w})$, is a standard estimate of $t(w)$. This provides far more accurate approximations for the distribution of $t(\hat{w})$ than its asymptotic normality. %NOT USED: The building blocks of the Edgeworth expansions are the {\it cumulant coefficients } of the estimate. These cumulant coefficients are also needed for bias reduction, Bayes estimates and confidence regions. We give {\it chain rules} for the cumulant coefficients of $t(\hat{w})$ in terms of those of $\hat{w}$ and the derivatives of $t(w)$, up to those needed for 5th order Edgeworth expansions for $t(\hat{w})$ and its {\it tilted expansion}, useful for the tail of the distribution.

The influence of polysialic acid (PSA) and sialic acid (SA) on the gut microbial community composition and metabolites in healthy human was investigated using a bionic gastrointestinal reactor. The results indicated that PSA and SA significantly changed the gut microbiota and metabolites in different degrees. PSA can increase the relative abundances of Faecalibacterium and Allisonella, whereas SA can increase those of Bifidobacterium and Megamonas. Both can significantly increase the content of short-chain fatty acids. The results of metabolome analysis showed that PSA can upregulate ergosterol peroxide and gallic acid and downregulate the harmful metabolite N-acetylputrescine. SA can upregulate 4-pyridoxic acid and lipoic acid. PSA and SA affect gut microbiota and metabolites in different ways and have positive effects on human health. These results will provide reference for the further development of PSA- and SA-related functional foods and health products.

Keywords: Green human resource management1; Green supply chain management2; Regulation and legislation3; Sustainable development goals4.

Malaria is rare in Europe, but it is a medical emergency and programs for its control should ensure access to early diagnosis and prompt treatment within 24-48 h of the symptom’s onset. The consistent number of imported malaria cases and the risk of reappearance of autochthonous cases stimulated laboratories in non-endemic countries to evaluate diagnostic methods/algorithms: microscopy remains the gold standard, but with limitations. RDTs have greatly expanded the ability to diagnose malaria for rapid results due to simplicity and low cost, but they lack sensitivity and specificity. PCR-based assays provide more relevant information but need well-trained technicians. According to WHO global Technical Strategy for Malaria 2016-2030, the future direction for a rapid diagnosis is the development of Point-Of-Care Testing, which would be helpful for prompt/accurate treatment and for preventing the diseases spread. Despite the limitations of current diagnostic methods, they play important roles in dealing with the global malaria situation, including decreasing its incidence. Recently evidence suggested that Artificial Intelligence could be utilized for assisting pathologists in malaria diagnosis. Future studies need to be conducted to see whether this system can be used for routine malaria diagnostic procedures.

The improvement of agricultural low-carbon efficiency is an important path to promote the realization of the "double carbon" goal in the Yellow River Basin. In the context of rapid urbanization development, it is of great significance to explore whether the promotion of urbanization will affect the agricultural low-carbon efficiency. Based on the panel data of 75 cities in the Yellow River Basin from 2000 to 2020, this paper uses super-DEA model, three-dimensional kernel density model and Markov chain model to measure and analyze the spatio-temporal evolution of agricultural low-carbon efficiency in the Yellow River Basin, on this basis, the panel Tobit model is used to analyze the relationship between urbanization and low-carbon efficiency in agriculture. The results show that: (1) The level of agricultural low-carbon efficiency in the Yellow River Basin is low and has not reached the effective state, showing a slow downward trend in general, among which, the agricultural low-carbon efficiency in the lower reaches is higher than that in the middle reaches, and the upper reaches is the lowest. (2) The agricultural low-carbon efficiency in the Yellow River Basin has a negative trend of transferring to the low level on the whole, and tends to maintain the original state level, and it is difficult to realize the leapfrog transfer between states. Agricultural low-carbon efficiency has obvious spatial spillover effect and "club convergence" phenomenon, high efficiency area has a positive driving effect on the neighborhood area, while low efficiency area has a negative impact on the neighborhood area. (3) The level of urbanization has a significant positive impact on the low-carbon efficiency of agriculture in the upper, middle and lower reaches of the Yellow River Basin, which plays an important role in promoting the green development of agriculture. Finally, based on the above research conclusions, relevant policy recommendations were put forward, in order to provide references for promoting the improvement of low-carbon agricultural efficiency and promoting high-quality agricultural development in the Yellow River Basin.

Renewable jet fuel (RJF) production has been recognized as a promising approach for reducing the aviation sector's carbon footprint. Over the last decade, commercial production of RJF has piqued the interest of airlines and governments around the world. However, RJF production can be challenging due to its dispersed supply resources. Furthermore, the production of RJF is more costly compared to producing conventional jet fuel. In this study, using a mixed integer linear program (MILP), we design an RJF supply chain network in which we obtain an optimized configuration of the supply chain and determine operational decisions required to meet RJF demand at airports. To accelerate commercialization of RJF production, we considered four different monetary incentive programs, which could cover the supply chain’s costs. This study is validated by employing the model to design an RJF supply chain in the Midwestern US. Results from this study are promising as they show the supply chain can achieve commercialization with partial financial coverage from the incentive programs. Based on the findings of this study, policymakers can devise policies to commercialize RJF production and accelerate its adoption by industry.

Grain supply is the lifeblood of a country, and the stability of the supply chain is a crucial prerequisite for ensuring national grain security. This paper draws on the definition of resilience in physics and economics. It takes supply chain fracture resilience, impact resilience, and synergy resilience as the secondary indicators. It constructs a comprehensive evaluation indicator system of the grain supply chain resilience, measures the resilience indicator of China's grain supply chain from 1996 to 2021, and analyzes the role of supply, cost, exchange rate, and other external shocks in influencing the resilience of China's grain supply chain on this basis. The study found that the overall level of China's total grain supply chain resilience has been growing year by year and can be divided into three stages: low-level stabilization stage, continuous growth stage, and high-level stabilization stage. Grain supply chain fracture resilience has been growing steadily, grain supply chain impact resilience fluctuation is more obvious, and grain supply chain synergy resilience has been changing more gently. In the inquiry of the impact of external shocks on the resilience of China's grain supply chain, it was found that world grain exports and the RMB exchange rate have a significant positive impact on China's grain supply chain resilience level, while the international oil price has a significant negative impact. Based on this, the paper puts forward suggestions for ensuring stable production and supply in the grain market, improving the structure of foreign trade in grain, and actively coping with international commodity price shocks.

Allergies are a common and increasing health problem affecting millions of people worldwide. In addition to genetic predisposition, this increase in allergic cases is attributed to air pollution, climate change, more time spent indoors, lack of physical activity, and alterations in eating habits. The Mediterranean diet (MD), which includes a lot of fruits and vegetables, whole grains, legumes, nuts, olive oil and fish has been linked to a variety of health benefits, including a lower risk of chronic and allergic diseases. The purpose of this paper is to explore the effects of the dietary components of the MD on food allergies. Electronic databases PubMed, Scopus, Science Direct, and EBSCO were used to conduct this systematic review up to March 2023. 696 studies were initially identified and nine were included (five human and four animal studies). The findings of this review showed an overall beneficial effect between the food components of the MD and food allergies. Although the results are promising, the limited number of studies highlights the need for more research.

World health is increasingly threatened by the growing number of spice-related food hazards. Further development of reliable methods for rapid, non-targeted identification of counterfeit ingredients within the supply chain is needed. ENEA has developed a portable, user-friendly photoacoustic laser system for food fraud detection, based on a quantum cascade laser and multivariate calibration. Following a study on the authenticity of saffron, the instrument was challenged with a more elusive adulterant, olive leaves in oregano. The results show that the reported method of laser sensing and chemometric analysis was able to detect adulterants at mass ratios of at least 20% in less than five minutes.

Locust is a pest that attacks human and animal food and endangers national security by threatening food security. Spraying is the easiest and fastest way to deal with them. But the easiest way is not always the best way. With chemical resistance, not only will permanent immunity from locust attacks not arise, but they will also become resistant to poisons. While we have to pay billions of dollars annually for this strategy, we will also cause water and soil pollution. Therefore, the research results of other researchers were used and modeled to measure the possibility of hunting invasive locusts to investigate the possibility and benefits of this action. So, this study was conducted in the field method. The obtained results indicate that it is possible to hunt invasive locusts. If traps are placed on time and in the right place, the possibility of preserving crops after the pest attack increases by 2.3 times more in protected fields than in unprotected fields. By hunting locusts, fields and even pastures are preserved, poisons are prevented from entering the food chain and ecosystem, part of the economic loss of farmers affected by the invasion of locusts will be compensated, and by providing animal feed through hunting locusts, water consumption will be reduced, soil erosion and energy consumption are saved.

Nowadays, frameworks and models are critical to enabling organizations to identify their current sustainability integration into business and to follow up on these initiatives over time. In this context, the maturity models offer a structured way of analyzing how a supply chain meets specific sustainability requirements and which areas demand attention to reach maturity levels. This study proposes a five-level maturity model to help supply chains identify their level of engagement with sustainability practices combining three perspectives: intra and inter-organizational sustainability practices, triple-bottom-line approach and critical areas for sustainability. All the steps followed in constructing the maturity model were based on a literature review, and case studies supported its improvement, application, and testing. The proposed model presents many advantages, such as being used as a self-assessment tool, a roadmap for sustainability behaviour improvement, and a benchmarking tool to evaluate and compare standards and best practices among organizations and supply chains.

Urban growth in various cities across the world, especially in developing countries, leads to land use change. Thus, predicting future urban growth in the most rapidly growing region of Nigeria becomes a significant endeavor. This study analyzes land use and land cover (LULC) change and predicts the future urban growth of the Lagos metropolitan region, using Cellular Automata (CA) model. To achieve this, the GlobeLand30 datasets from years 2000 and 2010 were used to obtain LULC maps, which were utilized for modeling and prediction. Change analysis and prediction for LULC scenario for 2030 were performed using LCM and CA_Markov chain modeling. The results show a substantial growth of artificial surfaces, which will cause further reductions in cultivated land, grassland, shrubland, wetland, and waterbodies. There was no appreciable impact of change for bare land, as its initial extent of cover later disappeared completely. Additionally, artificial surfaces/urban growth in Lagos expanded to the neighboring towns and localities in Ogun State during the study period, and it is expected that such growth will be higher in 2030. Lastly, the study findings will be beneficial to urban planners and land use managers in making key decisions regarding urban growth and improved land use management in Nigeria.

Water resource is considered as a significant factor in development of regional environment and society. Water consumption prediction can provide important decision basis for the regional water supply scheduling optimisations. According to the periodicity and randomness nature of the daily water consumption data, a Markov modified autoregressive moving average (ARIMA) model is proposed in this study. The proposed model, combined with the Markov chain, can correct the prediction error, reduce the continuous superposition of prediction error, and improve the prediction accuracy of future daily water consumption data. The daily water consumption data of different monitoring points are used to verify the effectiveness of the model, and the future water consumption is predicted, in the study area. The results show that the proposed algorithm can effectively reduce the prediction error compared to the ARIMA.

The concentration of all-trans-retinoic acid, the bioactive derivative of vitamin A, is critically important for the optimal performance of numerous physiological processes. Either too little or too much of retinoic acid in developing or adult tissues is equally harmful. All-trans-retinoic acid is produced by the irreversible oxidation of all-trans-retinaldehyde. Thus, the concentration of retinaldehyde as the immediate precursor of retinoic acid has to be tightly controlled. However, the enzymes that produce all-trans-retinaldehyde for retinoic acid biosynthesis and the mechanisms responsible for the control of retinaldehyde levels have not yet been fully defined. The goal of this review is to summarize the current state of knowledge regarding the identities of physiologically relevant retinol dehydrogenases, their enzymatic properties and tissue distribution, and to discuss potential mechanisms for the regulation of the flux from retinol to retinaldehyde.

The out-of-equilibrium dynamics of many body systems has recently received a burst of interest, also due to experimental implementations. The dynamics of both observables, such as magnetization and susceptibilities, and quantum information related quantities, such as concurrence and entanglement entropy, have been investigated under different protocols bringing the system out of equilibrium. In this paper we focus on the entanglement entropy dynamics under a sinusoidal drive of the tranverse magnetic field in the 1D quantum Ising model. We find that the area and the volume law of the entanglement entropy coexist under periodic drive for an initial non-critical ground state. Furthermore, starting from a critical ground state, the entanglement entropy exhibits finite size scaling even under such a periodic drive. This critical-like behaviour of the out-of-equilibrium driven state can persist for arbitrarily long time, provided that the entanglement entropy is evaluated on increasingly subsytem sizes, whereas for smaller sizes a volume law holds. Finally, we give an interpretation of the simultaneous occurrence of critical and non-critical behaviour in terms of the propagation of Floquet quasi-particles.

Irish beef farms have experienced poor viability longitudinally, with officially acknowledged ‘crisis’ levels in 2013. In response, beef Producer Organisation (PO) legislation was introduced. Through the lens of international evidence in the literature about how POs function, this paper presents an analysis of Irish stakeholders’ views in the context of a public consultation process. While stakeholders indicate the need for individual POs to collaborate, little emphasis is placed on other factors necessary for success: collaboration with other chain actors; and market differentiation of products. Stakeholders identified primary threats as poor engagement on the part of both farmers and processors/purchasers.

The increased consumption of high fat-containing foods has been linked to the prevalence of obesity and abnormal metabolic syndromes. Rhizopus oligosporus, a fungus in the family Mucoraceae, is widely used as a starter for homemade tempeh. Although R. oligosporus can prevent the growth of other microorganisms, it grows well with lactic acid bacteria (LAB). Lactobacillus plantarum can produce β-glucosidase, which catalyzes the hydrolysis of glucoside isoflavones into aglycones (with greater bioavailability). Therefore, the development of a soybean-based functional food by the co-inoculation of R. oligosporus and L. plantarum is a promising approach to increase the bioactivity of tempeh. In this study, the ameliorative effect of L. plantarum in soy tempeh on abnormal carbohydrate metabolism in high-fat diet (HFD)-induced hyperglycemic rats was evaluated. The co-incubation of L. plantarum with R. oligosporus during soy tempeh fermentation reduced the homeostatic model assessment of insulin resistance, HbA1c, serum glucose, total cholesterol, triglyceride, free fatty acid, insulin, and low-density lipoprotein contents and significantly increased the high-density lipoprotein content in HFD rats. It also increased the LAB counts as well as the bile acid, cholesterol, triglyceride, and short-chain fatty acid contents in the feces of HFD rats. Our results suggested that the modulation of serum glucose and lipid levels by LAB occurs via alterations in the internal microbiota, leading to the inhibition of cholesterol synthesis and promotion of lipolysis. Tempeh, produced with both L. plantarum and R. oligosporus, may be a beneficial dietary supplement for individuals with abnormal carbohydrate metabolism.

Although the signaling function of Na/K ATPase is been studied for decades, the chasm between the pumping function and the signaling function of Na/K – ATPase is still an open issue. This article explores the relationship between ion pumping and signaling with attention to the amplification of oxidants through this signaling function. Starting with some experimental observations published by our laboratories and others, we develop some predictions regarding cellular oxidant stress.

This qualitative study explores the complexities of managing suppliers for quality among Italian restaurant owners, investigating their perspectives, challenges, and strategic approaches in supplier management. Through semi-structured interviews with 15 restaurant owners across diverse regions of Italy, key themes emerged regarding supplier selection criteria, challenges in supplier management, strategies for ensuring quality, and the impact of external factors on supply chain dynamics. Findings reveal that authenticity, reliability, and sustainability are paramount in supplier selection, aligning with consumer expectations for genuine Italian ingredients and culinary excellence. Economic pressures, operational disruptions, and external influences, exacerbated by events like the COVID-19 pandemic, necessitate adaptive strategies such as cost-effective sourcing, rigorous quality control measures, and technological integration to maintain supply chain continuity and uphold quality standards. Strategic initiatives, including rigorous quality assurance protocols, digital procurement platforms, and collaborative partnerships with suppliers, enhance transparency, efficiency, and responsiveness in supply chain operations. Entrepreneurial initiatives and emotional intelligence play crucial roles in fostering innovative sourcing strategies and building trust-based relationships with suppliers, enhancing supply chain resilience and responsiveness to market demands. External factors, such as market dynamics and sustainability trends, underscore the need for continuous adaptation and strategic foresight in supplier management practices. The study contributes to understanding the intricate dynamics of supplier management in Italian cuisine, offering insights for enhancing operational efficiency, maintaining quality standards, and fostering sustainable supplier relationships in the food service industry.

This qualitative study explores how businesses are adapting their Supplier Relationship Management (SRM) strategies to address the challenges and capitalize on the opportunities presented by evolving e-commerce trends. Through in-depth interviews with key industry stakeholders, the research investigates the integration of advanced technologies such as artificial intelligence (AI), blockchain, and the Internet of Things (IoT) into SRM practices. Findings reveal that these technologies enhance efficiency, transparency, and responsiveness within supply chains, enabling businesses to navigate complexities such as supply chain dynamics, fluctuating consumer demand, and regulatory compliance. The study identifies effective strategies employed by businesses, including enhancing communication channels with suppliers, diversifying supplier bases, and investing in technological advancements. These strategies enable businesses to mitigate risks, improve collaboration, and drive innovation, thereby maintaining competitive advantage in the digital marketplace. Collaborative practices such as joint product development, shared risk management, and co-investment in technology emerge as critical drivers of successful SRM. Ultimately, this research contributes to a deeper understanding of SRM in the context of e-commerce, offering insights into how businesses can optimize their supply chain operations amidst technological disruptions and market fluctuations. The findings underscore the importance of proactive adaptation and strategic alignment with suppliers to foster resilient and agile supply chains. As e-commerce continues to evolve, businesses must leverage these insights to refine their SRM strategies and sustain growth in an increasingly competitive environment.

This study investigates the adoption of emerging technologies in procurement within supply chain management, focusing on the transformative potential of artificial intelligence (AI) and blockchain. Through a qualitative approach, involving semi-structured interviews with procurement professionals and technology experts, the study explores how these technologies enhance operational efficiency, optimize inventory management, and improve supply chain transparency and trust. AI-driven predictive analytics were found to significantly enhance demand forecasting, inventory optimization, and supplier performance evaluation, fostering data-driven decision-making and proactive risk management. Blockchain technology ensures secure and transparent transactions, facilitating compliance with ethical sourcing standards and reducing risks associated with counterfeit goods. Despite these benefits, organizations face substantial challenges in adopting these technologies, including data security concerns, integration complexities with existing IT infrastructure, and skills shortages in AI and blockchain expertise. Leadership commitment and organizational readiness are identified as crucial enablers for overcoming these barriers and driving successful technology adoption. The study also highlights the strategic importance of supplier relationship management, emphasizing how emerging technologies enhance real-time collaboration, performance insights, and contractual transparency. By addressing these challenges and leveraging technological innovations strategically, organizations can achieve sustainable growth, resilience, and competitive advantage in an increasingly digital and interconnected global economy. The findings contribute to advancing knowledge on procurement innovation and offer valuable insights for organizations seeking to navigate the complexities of technology-driven procurement practices. Future research directions may explore the long-term impact of technology adoption on supply chain dynamics, sustainability initiatives, and organizational performance.

This qualitative study explores the role of supply chain partnerships in enhancing brand value through collaborative marketing efforts. By analyzing diverse cases from industries including consumer electronics, apparel, automotive, and food and beverage, the research examines how different forms of partnerships—strategic alliances, co-marketing, joint ventures, and supplier integrations—contribute to brand value. The study employed a multiple case study design, incorporating semi-structured interviews, document analysis, and participant observations to gather data. The findings reveal that these partnerships enable companies to leverage complementary strengths, resulting in enhanced innovation, product quality, sustainability, market reach, and ethical standards. Collaborative marketing strategies such as joint product launches, sustainable branding campaigns, and co-developed customer programs are identified as key drivers of brand value, effectively increasing brand awareness, customer loyalty, market share, and perceived quality. Despite challenges like coordination complexity, goal misalignment, cultural differences, and cost management issues, the benefits realized—such as improved brand image, faster time-to-market, and reduced costs—demonstrate the substantial value of effective supply chain partnerships. The study underscores the importance of strategic alignment between supply chain activities and brand objectives, highlighting that successful partnerships foster deeper consumer engagement and stronger market positions. This research provides actionable insights for companies seeking to optimize their supply chain collaborations to enhance brand value, offering a foundation for future studies and practical applications in supply chain management and marketing. The findings contribute to a deeper understanding of how supply chain partnerships can be strategically managed to drive brand excellence in a competitive market environment.

The integration of supply chain data analytics with marketing strategies has become increasingly critical for organizations seeking to enhance customer insights and competitive advantage in today's dynamic business environment. This qualitative research explores the intersection of these two disciplines, focusing on implementation strategies, benefits, challenges, and future directions. Through semi-structured interviews with industry experts and stakeholders, key themes emerged, highlighting the importance of cross-functional collaboration, technological integration, and robust data governance in achieving effective integration. The study identifies significant benefits, including enhanced customer insights, improved operational efficiencies, and competitive advantage through personalized marketing strategies and optimized supply chain management. However, challenges such as data silos, technological complexities, and regulatory compliance issues pose barriers that require strategic solutions and organizational commitment. Future directions point towards the continued evolution of predictive analytics, AI-driven solutions, and sustainability integration, shaping the future landscape of supply chain management and marketing. Proactive engagement with regulatory frameworks and ethical considerations will be crucial in navigating these challenges and building trust with consumers. Ultimately, this research contributes to a deeper understanding of how organizations can leverage data analytics to drive strategic decision-making, enhance customer relationships, and achieve sustainable growth in an increasingly data-driven economy.

This qualitative research explores the intricate relationship between cultural influences on supply chain practices and their implications for marketing strategies. Cultural dimensions such as individualism versus collectivism, uncertainty avoidance, and contextuality significantly shape decision-making processes, risk management strategies, and relationship dynamics within global supply chains. Through semi-structured interviews with supply chain managers, marketing executives, and cultural experts across diverse industries and regions, this study investigates how cultural values impact supply chain operations and consumer engagement strategies. Key findings highlight that collectivist cultures prioritize consensus-building and long-term relationships, fostering trust and collaboration among supply chain partners. In contrast, individualist cultures emphasize efficiency and accountability but may face challenges in relationship building. Risk management practices vary with cultural orientations towards uncertainty, influencing the adoption of structured versus flexible approaches to mitigate disruptions. In terms of marketing implications, the study underscores the importance of cultural sensitivity in crafting effective strategies. High-context cultures require marketing messages that resonate emotionally through implicit communication and cultural symbolism, while low-context cultures prefer clear, direct messaging focusing on product benefits. The study concludes by advocating for cultural competence as a strategic imperative for global businesses, enabling them to leverage cultural diversity for innovation and competitive advantage. It emphasizes the need for continuous adaptation to cultural nuances and market dynamics to foster inclusive collaboration and achieve sustainable growth in a globalized economy.

This qualitative research explores the intricate relationship between cultural influences on supply chain practices and their implications for marketing strategies. Cultural dimensions such as individualism versus collectivism, uncertainty avoidance, and contextuality significantly shape decision-making processes, risk management strategies, and relationship dynamics within global supply chains. Through semi-structured interviews with supply chain managers, marketing executives, and cultural experts across diverse industries and regions, this study investigates how cultural values impact supply chain operations and consumer engagement strategies. Key findings highlight that collectivist cultures prioritize consensus-building and long-term relationships, fostering trust and collaboration among supply chain partners. In contrast, individualist cultures emphasize efficiency and accountability but may face challenges in relationship building. Risk management practices vary with cultural orientations towards uncertainty, influencing the adoption of structured versus flexible approaches to mitigate disruptions. In terms of marketing implications, the study underscores the importance of cultural sensitivity in crafting effective strategies. High-context cultures require marketing messages that resonate emotionally through implicit communication and cultural symbolism, while low-context cultures prefer clear, direct messaging focusing on product benefits. The study concludes by advocating for cultural competence as a strategic imperative for global businesses, enabling them to leverage cultural diversity for innovation and competitive advantage. It emphasizes the need for continuous adaptation to cultural nuances and market dynamics to foster inclusive collaboration and achieve sustainable growth in a globalized economy.

This qualitative investigation delves into the intricate interplay of cultural factors within supply chain integration, aiming to elucidate how diverse cultural dimensions shape communication dynamics, decision-making processes, and collaborative efforts among global supply chain practitioners. Employing a phenomenological approach, the study explores the lived experiences and subjective perceptions of supply chain managers and professionals, providing nuanced insights into the profound impact of national culture, organizational culture, digital technologies, and sustainability considerations on supply chain operations. Key findings highlight the significant influence of national culture, as conceptualized by Hofstede's cultural dimensions, on supply chain interactions. These dimensions—such as power distance, individualism versus collectivism, uncertainty avoidance, and masculinity versus femininity—play crucial roles in shaping how individuals perceive authority, manage risks, negotiate agreements, and engage in collaborative practices across diverse cultural contexts. Cultural norms and values deeply influence both intra-organizational dynamics and inter-organizational relationships within global supply chains. Organizational culture emerges as a pivotal determinant of supply chain integration success. Cultures characterized by transparency, trust, inclusivity, and a commitment to continuous improvement create environments conducive to effective cross-border collaboration. Conversely, organizations with conflicting or ambiguous cultural norms face challenges in aligning goals, fostering mutual understanding, and maintaining open communication channels with international partners. The study underscores the transformative role of digital technologies in enhancing supply chain management practices. Technologies such as blockchain, artificial intelligence, and the Internet of Things improve supply chain visibility, optimize operations, and enhance decision-making processes, strengthening resilience against disruptions. The adoption and integration of these technologies depend on organizational readiness, technological capabilities, and cultural acceptance within supply chain networks. Cultural factors influence the adoption pace, implementation strategies, and utilization patterns of digital technologies, emphasizing the need for strategic alignment between technological investments and cultural norms to maximize their potential benefits. Furthermore, sustainability considerations are critical in shaping cultural values and priorities within supply chain networks. Organizations increasingly recognize the importance of environmental sustainability, ethical sourcing practices, and corporate social responsibility in shaping their reputations, stakeholder relationships, and long-term business goals. Cultural factors significantly influence organizations' approaches to sustainability, guiding their strategic decisions and operational practices.

The gut has been a focus of chronic disease research. The gut microbiota produces metabolites that act as signaling molecules and substrates, closely influencing host health. Indigestible oli-gosaccharides (NDOs), as a common dietary fiber, play an important role in regulating the structure and function of gut microbiota. Their mechanism of action is mainly attributed to their carbon source as specific probiotics, producing related metabolites, and regulating the gut mi-crobial community. However, due to the selective utilization of oligosaccharides, some factors such as the types and structures of oligosaccharides have different impacts on the composition of microbial populations and the production of metabolites in the colon ecosystem. This review systematically describes the key factors influencing the selective utilization of oligosaccharides in microorganisms and elaborates how oligosaccharides affect the host's immune system, inflam-mation levels and energy metabolism by regulating microbial diversity and metabolic function, which in turn will affect the onset and progress of chronic diseases, especially diabetes, obesity, depression and intestinal inflammatory diseases, constipation. In this review, we re-examine the interaction mechanisms between gut microbiota and its associated metabolites and diseases, and explore new strategies for promoting human health and combating chronic diseases through di-etary interventions.

This qualitative research investigates the intricate relationship between market dynamics and supply chain sustainability in the renewable energy sector. Amidst the global energy transition, renewable energy has emerged as a crucial player in mitigating climate change and fostering sustainable development. However, ensuring the sustainability of renewable energy supply chains presents complex challenges shaped by various market forces. Through semi-structured interviews and thematic analysis, this study explores how policy frameworks, technological innovation, market competition, consumer preferences, and investor demands influence sustainability practices across the renewable energy supply chain. The findings highlight the critical role of supportive policy environments, technological advancements, and stakeholder collaboration in driving sustainability performance and mitigating risks within renewable energy supply chains. Furthermore, the study identifies challenges such as supply chain complexity, regulatory compliance, and stakeholder engagement, underscoring the need for collaborative efforts and multi-stakeholder partnerships. By addressing these challenges and leveraging opportunities, stakeholders can advance sustainability goals, mitigate climate change impacts, and foster a more resilient and equitable renewable energy sector. The research contributes to a deeper understanding of market dynamics and supply chain sustainability in the renewable energy sector, offering insights for policymakers, industry stakeholders, and sustainability practitioners to inform evidence-based decision-making and drive positive change.

In the past few years, cloud-based additive manufacturing has shown its application and potential in industries. For this reason, when the demand for cloud-based additive products increases, efficient scheduling of related tasks becomes more important to achieve optimized duration. This research proposes a Heuristic Scheduling Algorithm (HSA) for use in Cloud-Based Additive Manufacturing (CBAM) with an approach to Critical Chain Buffer Management (CC/BM). This research aims to schedule and optimize the time in cloud-based additive manufacturing, in addition to the parts production process, it also includes the steps of receiving online orders and informing the manufacturing unit and sending them to the customer. The HSA proposed in this research consists of three phases 1- Buffer sizing, 2- Additive manufacturing and logistics scheduling, and 3- Buffer controlling. To evaluate, the performance of the algorithm is simulated. The finding shows that the proposed HAS can effectively solve the CBAM scheduling problem.

Food production is a complex matter, affecting people’s lives, organizations’ profits, and the well-being of the whole planet and has multifaceted ethical considerations surrounding its production, distribution, and consumption. This paper addresses the pressing need to confront ethical challenges within the food system, encompassing issues such as environmental sustainability, food security, and individual food choices for better oral and systemic health of all individuals around the globe. From agricultural practices to global trade and food waste, ethical implications are addressed across various domains, highlighting the interconnectedness of ethical decision-making in the food industry. Central themes explored include the ethical dimensions of food production methods, the impact of global trade on food ethics, and the role of individuals in making ethically informed food choices. Additionally, the paper dives into the spiritual and physical significance of food, particularly through the lens of oral health as a gateway to holistic well-being. Recognizing the complexity of the food ecosystem, the paper calls for serious interventions in legislation and economics to promote ethical protocols and techniques for sustainability reasons. It emphasizes the importance of ethical considerations in food safety management systems, regulatory frameworks, and quality standards. Moreover, the paper underscores the need for a comprehensive approach to address ethical dilemmas and moral values inherent in the food industry and oral health policies, advocating for the adoption of the precautionary principle and ethical decision-making frameworks. The article aims to serve as a call to action for stakeholders across the food industry and the healthcare sector, to prioritize ethical practices, promote transparency, rearrange economic parameters and work towards a more sustainable and equitable food system for inner and outer oral and systemic health and human sustainability for all.

This review deals with the developmental origins of extraocular, jaw and laryngeal muscles, the expression, regulation and functional significance of myosin heavy chains (MyHCs) they express and changes in MyHC expression during phylogeny. Myogenic progenitors from mesoderm in the prechordal plate and branchial arches specify craniofacial muscle allotypes with different repertoires for MyHC expression. To cope with very complex eye movements, extraocular muscles express 11 MyHCs, ranging from the superfast extraocular MyHC to the slowest, non-muscle MyHC IIB. They have distinct global and orbital layers, singly- and multiply-innervated fibres, longitudinal MyHC variations, and palisade endings that mediate axon reflexes. Jaw-closing muscles express the high-force masticatory MyHC, cardiac or limb MyHCs depending on the appropriateness for the acquisition and mastication of their food. Laryngeal muscles express extraocular and limb muscle MyHCs but shift towards slower MyHCs in large animals. During postnatal development, MyHC expression of craniofacial muscles is subject to neural and hormonal modulation. The primary and secondary myotubes of developing EOMs are postulated to induce, via different retrogradely transported neurotrophins, the rich diversity of neural impulse patterns that regulate the specific MyHCs they express. Thyroid hormone shifts 2A MyHC towards 2B in jaw, laryngeal muscles and possibly extraocular muscles.

“All diseases originate in the gut.” Hippocrates (400 BC) A healthy gut microbiome via the gut-brain-axis (GBA) elevates heart rate variability (HRV), a general measure of health and well-being. A dysbiotic gut microbiome, low in biodiversity and butyrate producers, alters tryptophan metabolism with release of proinflammatory cytokines, predominantly TNF-α, IL-6, and IL-1β. These also characterize chronic inflammation, oxidative stress, and a multitude of diseases, all exhibiting low HRV. Gut dysbiosis upregulates IFN-γ and with it IDO (indoleamine 2,3 dioxygenase). Tryptophan pivots from serotonin synthesis to that of IDO induced kynurenine, increasing the kynurenine to tryptophan ratio (KTR). An elevated KTR is positively linked to neurodegenerative and autoimmune diseases and negatively linked to HRV. Elevated IDO activity is not only enzymatic but also an intracellular signal transducer potentiated by TGF-β. This cytokine is the primary determinant of the TME. Also proposed is the gut-lung dysbiosis concept and consequent degradation of ACE2 (richest in lungs and gut). Leaky gut induced autoantibodies related to G-protein coupled receptors (GPCRs) in combination with increased Ang II further potentiate oxidative stress. Aldosterone and paroxysmal orthostatic tachycardia syndrome (POTS) paradoxes are highlighted in the context of GPCR and gut dysbiosis, and the role of Candida is explored. The triple play of a prebiotic (d-mannose), probiotic (bifidobacteria and lactobacilli), and postbiotic (butyrate) might improve intestinal barrier integrity, oppose entry of GPCR antigens, suppress the inflammatory cytokine triad, balance IFN-γ and TGF-β, suppress oxidative stress, depress KTR, elevate HRV, and extend lifespan and its quality.

Hydrogen sulfide (H2S) is an environmental toxicant of health concern. The brain is a major target in acute H2S poisoning. This study was to test the hypothesis that acute and subchronic ambient H2S exposures alter the brain metabolome. Male 7-8 week-old C57BL/6J mice were exposed by whole-body inhalation to 1000 ppm H2S for 45 min and euthanized at 5 min or 72 h for acute exposure. For subchronic study, mice were exposed to 5 ppm H2S 2 h/day, 5 days/week for 5 weeks. The brainstem was removed for metabolomic analysis. Enrichment analysis showed the metabolomic profiles in acute and subchronic H2S exposures matched with those of cerebral spinal fluid from patients with seizures or Alzheimer’s disease. Acute H2S exposure decreased excitatory neurotransmitters, aspartate and glutamate, while the inhibitory neurotransmitter, serotonin, was increased, which may explain H2S-induced loss of consciousness. Branched-chain amino acids and glucose were increased by acute H2S exposure. Subchronic H2S exposure within OSHA guideline surprisingly decreased serotonin altering central nervous system. In subchronic H2S exposure, glucose was decreased while polyunsaturated fatty acids, inosine, and hypoxanthine were increased. Collectively, these results provide important mechanistic clues of acute and subchronic ambient H2S poisonings and show that H2S alters brainstem metabolome.