The eutrophication of open water bodies, especially in coastal water area, has received intensive public focuses in recent years. Biological treatment of organic pollutants in industrial and domestic wastewater requires microbial flora to participate. The environmental impact of these microbes, particularly in regard to the spread of antibiotic resistance genes and pathogenicity in coastal water, remains largely unknown. We initiate studies to examine antibiotic resistance genes (ARGs) in microbial flora and study the mode of antibiotic spread in the coastal waters of Bohai Bay, North China by using high performance liquid chromatography-mass spectrum analysis and quantitative polymerase chain reaction. The metabolic features of bacteria related to the presence of ARGs in the coastal area showed the enrichment of Pseudomonadale species with triple resistance properties (ampicillin, kanamycin and gentamycin) at the estuary site locating adjacent to a coastal sewage treatment plant where both type I and type II polyketide synthase genes and b-lactam type antibiotics are detected. Pseudomonadale order is phylogenetically belonged to Proteobacteria Phylum, Gamma-proteobacteria Class and contains Pseudomonadaceae family and Pseudomonas genus. QPCR analysis suggests that the percent occupation of Pseudomonadale species to total Proteobacteria in the examined stations is close to several sampling stations close to sewage treatment plants, where consistent release of organic wastes occurred.

The evolution of human societal dynamics over the course of decades and centuries has led to an ever-increasingly complex digital modern life, one of the hallmark of which is the need for multi-tasking, inclusive of that with media. Is there an empirical mapping between this macroscopic (digital) evolution of the human societal dynamics (in terms of multi-tasking) and the microscopic evolution of the functional molecular units within cells (i.e., proteins) and their manifold cross-talks? Multi-tasking requires a certain degree of intrinsic or adapted flexibility which is as true at the bio-molecular level. Evolutionary diversification of structure-function relationship in proteins emphasizes the functional importance of intrinsically disordered entities (IDPs/IDRs) which are highly dynamic biological soft matters. Multi-functionality is favorably supported by their fluid-like shapes and other new malleable members of the protein family. The new wealth of knowledge coming from recent research on protein intrinsic disorder, fold-switching, moonlighting, hub proteins etc. has given us new insights into protein structure – functional relationship. This has led to a paradigm shift in protein science, clearly diverging from the traditional 'one structure – one function' model applicable to enzyme classes to a more complex understanding of protein functionality. This paradigm shift has caused scientists to delve deeper into the subject, exploring various evolutionary toys and tools to fit the cumulative multi-functional demands in higher organisms. This commentary covers the different evolutionary arsenals to achieve the growing multi-functionality and argues in favor of protein intrinsic disorder as probably the sharpest weapon of all.

The segmentation of abnormal regions is vital in smart manufacturing. However, the existing segmentation system for detecting sauce-packet leakage on intelligent sensors encounters an issue of imaging blurring caused by uneven illumination. This issue adversely affects segmentation performance, thereby impeding the rapid production of industrial assembly lines. To alleviate this issue, we propose the two-stage Illumination-aware Sauce-packet Leakage Segmentation (ISLS) method for intelligent sensors. The ISLS comprises two main stages: Illumination-aware region enhancement and leakage region segmentation. In the first stage, YOLO-Fastestv2 is employed to capture the Region of Interest (ROI), which reduces redundancy computations. Additionally, we propose an image enhancement to relieve the impact of uneven illumination, enhancing the texture details of ROI. In the second stage, we propose a novel feature extraction network. Specifically, we propose the Multi-scale Feature Fusion Module (MFFM) and the Sequential Self-Attention Mechanism (SSAM) to capture discriminative representations of leakage. The multi-level features are fused by MFFM with a small number of parameters, which capture leakage semantics at different scales. The SSAM realizes the enhancement of valid features and the suppression of invalid features by adaptive weighting of spatial and channel dimensions. Furthermore, we generated a self-built dataset of sauce-packets, including 606 images with various leakage areas. Comprehensive experiments demonstrate that our ISLS method shows better results than several state-of-the-art methods, with additional performance analyses deployed on intelligent sensors to affirm the effectiveness of our proposed method. Our code is available at https://github.com/LSJ5106/SauceDetect.

Extra virgin olive oil (EVOO) is recognized for its numerous health benefits attributed to its rich phenolic components. NMR has emerged as a prevalent technique for precisely identifying these compounds. Among Mediterranean countries, Greece stands as the third-largest producer of olives, with the Epirus region notably advancing in olive cultivation, contributing significantly to the dynamic growth of the region. In this study, an NMR method was employed based on the acquisition of an 1H NMR spectrum along with the multiple resonant suppression in order to increase the sensitivity. Using the above method, 198 samples of extra virgin olive oil, primarily sourced from the Epirus region were analyzed and both the qualitative and quantitative aspects of phenolic compounds were acquired. In addition, we examined the effect of various factors, such as, variety, harvest month and region origin on the phenolic compounds’ concentration. The results revealed an average total phenolic content of 246 mg/kg, closely approaching the EU health claim limit of 250 mg/kg. Approximately 15% of the samples were confidently characterized as high-phenolic olive oil. The highest concentrations were observed in Thesprotia samples, with several Lianolia variety exceeding the total phenolic content of 400 mg/kg. Statistical tests demonstrated a significant influence of the olive variety and the month of fruit harvest on phenolic component concentration, followed by the region of origin. A very strong correlation was noted between the total phenolics content and the levels of oleocanthal and oleacein, with a correlation coefficient (r) of 0.924. Upon optimization of all factors affecting olive oil quality, the majority of EVOO from the Epirus region have the potential to be characterized as high in phenolic content.

The adoption of algorithms based on Artificial Intelligence (AI) has been rapidly increasing during the last years. However, some aspects of AI techniques are under heavy scrutiny. For instance, in many use cases, it is not clear whether the decisions of an algorithm are well-informed and conforming to human understanding. Having ways to address these concerns is crucial in many domains, especially whenever humans and intelligent (physical or virtual) agents must cooperate in a shared environment. In this paper, we introduce an application of an explainability method based on the creation of a Policy Graph (PG) based on discrete predicates that represent and explain a trained agent’s behaviour in a multi-agent cooperative environment. We show that from these policy graphs, policies for surrogate interpretable agents can be automatically generated. These policies can be used to measure the reliability of the explanations enabled by the PGs, through a fair behavioural comparison between the original opaque agent and the surrogate one. The contributions of this paper represent the first application of policy graphs in the context of explaining agent behaviour in collaborative multi-agent scenarios and presents experimental results that sets this kind of scenario apart from previous application in single-agent scenarios: when requiring collaborative behaviour, predicates that allow representing observations about the other agents are crucial to replicate the opaque agent’s behaviour and increase the reliability of explanations.

The coupling of AC and DC power will impact the protective actions on the AC side and pose a threat to the stable operation of the interconnection system. Therefore, a new longitudinal protection method is proposed based on the comprehensive distance similarity of voltage waveforms. Initially, the measured voltage and current data are extracted to calculate the reference voltage, and the voltage waveform fitting is optimized. Subsequently, the Euclidean dynamic time warp (DTW) distance and entropy weight method are utilized to process the voltage waveform, enabling the calculation of its comprehensive distance similarity. This similarity is adopted to determine fault location. A hybrid DC multi-feed AC/DC interconnection system, incorporating line commutated converter-voltage source converter (LCC-VSC) and line commutated converter-modular multilevel converter (LCC-MMC), was established in PSCAD, and fault data was simulated and output. The effectiveness of the protection scheme was validated using MATLAB. Simulation results demonstrate that the proposed method can accurately distinguish between faults inside and outside a region. When compared to existing protection methods, it demonstrates superior performance in resisting transition resistance and noise interference, while also mitigating the impact of data asynchronicity. The speed and reliability of the method are further enhanced.

In the autonomous navigation of mobile robots, precise positioning is crucial. In forest environments with weak satellite signals or in sites disturbed by complex environments, satellite positioning accuracy has difficulty in meeting the requirements of autonomous navigation positioning accuracy for robots. This article proposes a binocular vision SLAM/UWB tightly coupled localization method. The core of this algorithm is based on an Extended Kalman Filter (EKF), which utilizes the displacement increment output by binocular vision ORB-SLAM and the positioning coordinates calculated via UWB positioning as measurement information to achieve data fusion. The research utilized the constructed experimental platform to collect images and UWB ranging data in outdoor environments and experimentally validated the combined positioning method. The experimental results show that this algorithm outperforms the use of the individual UWB or visual SLAM localization methods in terms of positioning accuracy. Compared with traditional single positioning algorithms, this algorithm exhibits better practicality and stability, and can effectively suppress the impact of UWB non line of sight errors. The average error under normal line of sight conditions is 0.058 m, the root mean square error (RMSE) is 0.080, and the average error under non-line-of-sight conditions is 0.081 m, with an RMSE of 0.084. There is no significant jump or drift. Through the tightly coupled processing of binocular vision SLAM and UWB positioning, more reliable and accurate mobile robot positioning can be achieved, providing a useful reference for the autonomous navigation of mobile robots in complex environments.

In this paper, an ultracompact combined sensor for displacement and angle synchronous measurement is proposed based on self-imaging effect of optical microgratings. Using a two-grating structure, linear and angular displacement can be measured by detecting the change of phase and amplitude of the optical transmission respectively within one single structure in meantime. The optical transmitted properties of the two-grating structure are investigated in both theory and simulation. Simulated results indicate that, the optical transmission changes in a sinusoidal relationship to the input linear displacement. Meanwhile, the amplitude of the curve decreases with an input pitch angle, indicating the ability for synchronous measurement within one single compact structure. The synchronous measurement of the linear displacement and the angle is also demonstrated experimentally. The results show a resolution down to 4nm for linear displacement measurement, and a sensitivity of 0.26mV/arcsec within a range of ±1° for angle measurement. Benefitting from a simple common-path structure without using optical components including reflectors and polarizers, the sensor shows an ultrahigh compactness for multiple-degrees-of-freedom measuring, indicating the great potential for this sensor in the fields such as integrated mechanical positioning and semiconductor fabrication.

Drones have been used in a variety of scenarios such as atmospheric monitoring, fire rescue, agricultural irrigation, etc., in which accurate environmental perception is of crucial importance for both decision-making and control. Among the drone sensors, the RGB camera is indispensable for capturing rich visual information for vehicle navigation but encounters a grand challenge in high-dynamic-range scenes that occur frequently in real applications. Specifically, the recorded frames suffer from under-exposure and over-exposure simultaneously and degenerate the successive vision tasks. To solve the problem, we take object tracking as an example and leverage the superior response of event cameras over a large intensity range to propose an event-assisted object tracking algorithm that can achieve reliable tracking under large intensity variations. Specifically, we propose to pursue feature matching from dense event signals, and based on which to (i) design a UNet-based image enhancement algorithm to balance the RGB intensity with the help of neighboring frames in the time domain, and then (ii) construct a dual-input tracking model to track the moving objects from intensity balanced RGB video and event sequence. The proposed approach is comprehensively validated in both simulation and real experiments.

The article explores Qualitative Comparative Analysis (QCA), an approach for establishing causal relationships between conditions and outcomes. QCA, applied in case studies and empirical analyses, facilitates generalizations for future research and addresses causal complexity by identifying various causal "recipes" leading to the same outcome. Three widely used QCA variants are Crisp-Set QCA (csQCA), Multi-value QCA (mvQCA), and Fuzzy-Set QCA (fsQCA), each with unique approaches. The article emphasizes the significance of bibliometric analysis in mapping a research field's intellectual structure, revealing key contributions and trends. In QCA, bibliometric analysis identifies leading researchers, affiliations, and influential countries. Results show QCA's widespread adoption across disciplines, with continuous growth in article production since 2013. The favored variant is fsQCA, followed by csQCA, and China notably contributes to QCA-related research. In conclusion, QCA proves a potent tool for discerning complex causal relationships in empirical studies, with its increasing interdisciplinary use indicating substantial potential for advancing scientific knowledge.

The International Maritime Organization (IMO) is enforcing increasingly stringent regulations on ship carbon emissions, The International Maritime Organization (IMO) has been implementing progressively strict regulations on ship carbon emissions, leading to the adoption of the virtual arrival (VA) method by many vessels to reduce their carbon footprint. However, the effectiveness of the traditional VA method often varies in busy ports with complex traffic organization scenarios. To address this, our study presents a novel, comprehensive model that integrates vessel scheduling with the VA approach. This model is designed to achieve a dual objective: reducing carbon emissions through Virtual Arrival and simultaneously minimizing vessel waiting times. In addition to these goals, it incorporates essential aspects of safety, efficiency, and fairness in port management, utilizing the NSGA-2 algorithm to find optimal solutions. This model has been tested and validated through a case study at Ningbo-Zhoushan port, employing its dataset. The results demonstrate that our innovative model and algorithm significantly outperform traditional scheduling methods, such as First-Come-First-Serve (FCFS) and Virtual-Arrival Last-Serve (VALS), particularly in terms of operational efficiency and reduction in vessel carbon emissions.

Given its exceptional attributes, aerogel is viewed as a material with immense potential. Being a natural polymer, cellulose offers the advantage of being both replenishable and capable of breaking down naturally. Cellulose-derived aerogels encompass the replenish ability, biocompatible nature, and ability to degrade naturally inherent in cellulose, along with additional benefits like minimal weight, extensive porousness, and expansive specific surface area. Even with increasing appreciation and acceptance, the undiscovered possibilities of aerogels within the textile sphere continue to be predominantly uninvestigated. In this context, we outline the latest advancements in the study of cellulose aerogel formulation and their diverse impacts on textile formations. Drawing from the latest studies, we reviewed the materials used for the creation of various kinds of cellulose-focused aerogels and their properties, analytical techniques, and multiple functionalities in relation to textiles. This comprehensive analysis extensively covers the diverse strategies employed to enhance the multi-functionality of cellulose-based aerogels in the textile industry. Additionally, we focused on the global market size of bio-derivative aerogels, companies in the industry producing goods, and prospects moving forward.

Seasonal snowpacks, characterized by their snow water equivalent (SWE), play a major role in the hydrological cycle, snow melt contributions to floods and the subsequent availability of water resources downstream. Accurately estimating SWE and understanding its spatial and temporal variations presents a considerable challenge, particularly within mountainous regions characterized by complex terrain and limited observational data. Seeking to enhance the performance of the widely used Soil and Water Assessment Tool (SWAT), we report a new approach characterising snowpack behaviour incorporating both modelled and remotely sensed derived SWE calibration data. We focus on the Chenab River Basin (CRB) a headwater catchment of the Indus Basin, globally significant in terms of human inhabitants and intensifying flood risk due to climate change. We conducted a thorough assessment of five satellite-derived and reanalysis-based precipitation datasets: ERA5-Land, CMORPH, TRMM, APHRODITE, and CPC UPP. This reveals significant levels of uncertainty in global precipitation products when compared to reference data from observed stations as well as in the resulting simulated streamflow from the SWAT model. Subsequently, we expanded the scope of the SWAT model to encompass the spatial and temporal simulation of SWE. This was achieved by incorporating information from remotely sensed and modelled SWE products, manually adjusting snow parameters in R-SWAT for both the main basin and at sub-basin scales. Integrating SWE from reference snow products into the calibration process, alongside streamflow data, substantially enhanced modelling accuracy to simulate SWE compared to the conventional auto-calibration and single-variable approaches reliant solely on streamflow data. This approach results in considerable improvement in SWE predictions and to some extent in streamflow simulation in catchments dominated by snow. This research highlights the potential of remote sensing and modelled SWE parameterisation in the absence of in-situ snowpack data in high-altitude environments. An improved understanding of SWE behaviour is vital for predicting hydrological responses spanning hazards to water resources in the populous downstream regions of the Indus Basin, especially in the face of climate change.

Multi-Object Tracking (MOT) is a key technology for Unmanned Aerial Vehicles (UAVs). Traditional tracking-by-detection methods firstly employ an object detector to retrieve targets in each image and then track them based on a matching algorithm. Recently, the popular multi-task learning methods has been dominating this area since they can detect targets and extract Re-Identification (Re-ID) features in a computationally efficient way. However, the detection task and the tracking task have conflicting requirements on image features, leading to the poor performance of the joint learning model compared to separate detection and tracking methods. The problem is more severe when it comes to UAV images due to the presence of irregular motion of large number of small targets. In this paper, we propose a balanced Joint Detection and Re-ID learning (JDR) network to address the MOT problem in UAV vision. To better handle the non-uniform motion of objects in UAV videos, the Set-Member Filter is applied which describes object state as a bounded set. An appearance matching cascade is then proposed based on target state set. Furthermore, a Motion-Mutation module is designed to address the challenges posed by the abrupt motion of UAV. Extensive experiments on the VisDrone-MOT2019 dataset demonstrate that our proposed model, termed as SMFMOT, outperforms state-of-the-arts by a large margin and achieves superior performance on the MOT tasks in UAV videos.

Image segmentation is the process of partitioning an image into multiple segments where the goal is to simplify the representation of the image and make the image more meaningful and easier to analyze. In particular, semantic segmentation is an approach of detecting the classes of objects, based on each pixel. In the past, most semantic segmentation models were for only one single style, such as urban street views, medical images, or even Manga. In this paper, we proposed a semantic segmentation model called Dual-Pyramid Wide Residual Network (DPWRN) to solve the segmentation for cross-style datasets, which is suitable for diverse segmentation applications. The DPWRN integrated the Pyramid of Kernel paralleled with Dilation (PKD) and Multi-Feature Fusion (MFF) to improve the accuracy of segmentation. To evaluate the generalization of the DPWRN and its superiority over most state-of-the-art models, three datasets with completely different styles are tested in the experiments. Finally, the DPWRN verified its generalization and also showed its superiority over most state-of-the-art models.

In this study, we introduce and advanced multi-feature selection technique for bacterial classifi-cation employing the Salp Swarm Algorithm (SSA). We enhance SSA’s effectiveness by incorpo-rating the Opposition-Based Learning (OBL) strategy and the Local Search (LSA) algorithm. The proposed technique encompasses three key stages, streamlining the automated categorization of bacteria based on their distinctive features. The research adopts a multi-feature selection approach bolstered by an enhanced iteration of the Salp Swarm Algorithm (SSA). Enhancements include the utilization of Opposition-Based-Learning (OBL) to increase population diversity during search and Local Search Algorithms (LSA) to tackle local optimization challenges. The ISSA algorithm is designed to optimize the multi-feature selection by increasing the number of selected feature and improving classification accuracy. This study compares its performance with several other algo-rithms across ten distinct test datasets. The comparison results show that ISSA has better perfor-mance in terms of classification accuracy on 3 datasets consisting of 19 features, with a value reaching 73.75%. Additionally, ISSA excels in determining the optimal feature count and producing a better-fit value with a classification error rate of 0,249. Thus, the ISSA technique is expected to make a significant contribution to solving feature selection problems in bacterial analysis

Using traditional methods based on detection rules written by human security experts, there is a significant challenge in accurately detecting many network threats that are increasingly becoming sophisticated. In order to deal with the limitation of the traditional methods, network threat detection techniques utilizing artificial intelligence technologies such as machine learning are being extensively studied. Research has also been conducted on analyzing various string patterns in network packet payloads through natural language processing techniques to detect attack intent. However, due to the nature of packet payloads containing binary data as well as text data, a new approach is needed that goes beyond typical natural language processing techniques. In this paper, we study a token extraction method optimized for payloads using n-gram and byte pair encoding techniques. Furthermore, we generate embedding vectors that can understand the context of the packet payload using algorithms such as Word2Vec and FastText. We also compute the embedding of various header data associated with packets, such as IP addresses and ports. Given the combination of these features, we ensemble a text 1D-CNN and a multi-head attention network in a novel fashion. We validated the effectiveness of our classification technique with the CICIDS2017 open dataset and over half a million data collected by The Education Cyber Security Center (ECSC) currently operating in South Korea. The proposed model showed remarkable progress compared to previous studies, demonstrating a highly accurate classification performance with an F1-Score of 0.998. Our model can also preprocess and classify 150,000 network threats per minute to help security agents in the field divert their time to analyzing more complex attack patterns.

Due to the high computational burden and the high nonlinearity of the responses, crashworthiness optimizations are notoriously hard-to-solve challenges. Among various approaches, methods like the Successive Response Surface Method (SRSM) have stood out for their efficiency in enhancing baseline designs within a few iterations. However, these methods have limitations that restrict their application. Their minimum iterative resampling required is often computationally prohibitive. Furthermore, surrogate models are conventionally constructed using Polynomial Response Surface (PRS), a method that is poorly versatile, prone to overfitting, and incapable of quantifying uncertainty. Furthermore, the lack of continuity between successive response surfaces results in suboptimal predictions. This paper introduces the Multi-Fidelity Successive Response Surface (MF-SRS), a Gaussian process-based method, which leverages a nonlinear multi-fidelity approach for more accurate and efficient predictions compared to SRSM. After initial testing on synthetic problems, this method is applied to a real-world crashworthiness task: optimizing a bumper crossmember and crash box system. Results, benchmarked against SRSM and the Gaussian Process Successive Response Surface (GP-SRS) – a single-fidelity Gaussian process-driven extension of SRSM, show that MF-SRS offers distinct advantages. Specifically, it improves upon the specific energy absorbed optimum value achieved by SRSM by 14.1 %, revealing its potential for future applications.

This study will lead to the development of a numerical data set that will assist in the design of Savonius wind turbines. A major objective of this study is to develop a better design for Savonius turbine blades in order to increase their torque coefficients, rotational speeds, and pressure coefficients. As part of the experimental design methodology, a full dataset was generated by simulating three-dimensional scale models utilizing computational fluid dynamics (CFD) simulations that were validated by wind tunnel data. This process is multi-objective optimization for optimizing turbine performance. The twist angle, aspect ratio, and overlap ratio are all important factors in determining the optimal torque and power coefficients. The group method of data handling (GMDH) algorithm was utilized to model objective functions based on input-output data. The Pareto fronts were plotted using polynomial models obtained from the evolutionary Pareto-based optimization approach (modified NSGA-II), and the optimal commercial points were determined using TOPSIS. A comparison of three- and two-objective optimization data revealed that two-objective optimization data lie within the boundaries of a three-objective optimization problem. The torque coefficient, rotational speed, and power coefficient are all improved by 13.74%, 0.071%, and 5.32%, respectively, using multi-objective optimization. As a result of the multi-objective optimization of the turbine, some significant characteristics of objective functions were discovered.

Abstract: The ability to detect several types of cancer using a non-invasive, blood-based test holds the potential to revolutionize oncology screening. We mined tumor methylation array data from the Cancer Genome Atlas (TCGA) covering 14 cancer types and identified two novel, broadly oc-curring methylation markers at TLX1 and GALR1. To evaluate their performance as a general-ized blood-based screening approach, along with our previously reported methylation bi-omarker, ZNF154, we rigorously assessed each marker individually or combined. Utilizing the TCGA methylation data and applying logistic regression models within each individual cancer type, we found that the three-marker combination significantly increased the average area under the ROC curve (AUC) across the 14 tumor types compared to single markers (p= 1.158e-10; Friedman test). Furthermore, we simulated dilutions of tumor DNA into healthy blood cell DNA and demonstrated increased AUC of combined markers across all dilution levels. Finally, we evaluated assay performance in bisulfite sequenced DNA from patient tumors and plasma, in-cluding early-stage samples. When combining all three markers the assay achieved 100% sensi-tivity and specificity, as demonstrated in lung cancer plasma samples. In patient plasma from hepatocellular carcinoma, ZNF154 alone yielded the highest combined sensitivity and specificity values averaging 68% and 72%, whereas multiple markers could achieve higher sensitivity or specificity, but not both. Altogether this study presents a comprehensive pipeline for the identifi-cation, testing and validation of multi-cancer methylation biomarkers with a considerable poten-tial for detecting a broad range of cancer types in patient blood samples.

In response to the issue of vehicle escape guidance, this manuscript proposes a unified intelligent control strategy synthesizing optimal guidance and Meta Deep Reinforcement Learning (DRL). Optimal control with minor energy consumption is introduced to meet terminal latitude, longitude and altitude. Maneuvering escape is realized by adding longitudinal and lateral direction maneuver overloads. Maneuver command decision model is calculated based on Soft-Actor-Critic (SAC) networks. Meta learning is introduced to enhance autonomous escape capability, which improves generalization performance to time-varying scenarios not encountered in the training process. In order to obtain training samples at a faster speed, this manuscript uses the prediction method to solve reward values, which avoiding a large number of numerical integration. The simulation results manifest that the proposed intelligent strategy can achieve high precise guidance and effective escape.

Anti-microbial drugs and coccidiostat compounds are commonly used in poultry farming. These compounds are subsequently excreted and released into the environment via broiler litter (BL) and can re-enter the food chain as fertilizer and/or animal feed. Residues of such drugs can encourage the appearance of antibiotic-resistant bacteria (ARB), as well as toxicity, when found in animal feed. The aim of this study was to develop a multi-residue analytic method for assessing 30 an-ti-microbial drugs and coccidiostats associated with BL and investigate the effects of stacking treatment on anti-microbial and coccidiostat residue degradation in BL used for ruminant feed at the lab-scale. Today, most analytical methods used to identify and quantitate these drug residues are traditional, and may be specific to some antimicrobials. All call for lengthy sample preparation and may present limitations in assessing broiler litter. Such conventional mul-ti-anti-microbial/coccidiostat residue detection assays employ liquid-liquid extraction (LLE) and solid phase extraction (SPE) for sample purification. In our research, LLE and SPE were replaced by Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) clean-up steps for 30 an-ti-microbials and coccidiostats used in broiler farming and detection by liquid chromatography mass spectrometry (LC/MS/ MS). Using this method, recoveries were 70-120%, with the exception of norfloxacin and narasin, which showed recoveries of 67 and 68%, respectively. This analytical meth-od results show that eight samples were not detected in 42 samples, while in 34 samples, one or more drugs were present. Eighteen anti-microbial and coccidiostat residues were detected dur-ing one year sample collaction. The most frequently detected residues were narasin, nicarbazin, monensin, robenidine, oxytetracycline, chlortetracycline, norfloxacin and sulfachloropyridazine, seen at levels from 0.4 to 8.9 mg•kg-1 (ppm). Nineteen anti-microbials and one coccidiostat were degraded to 95% by the stacking treatment. However, tilmicosin and eight coccidiostats persisted in litter (26-100%). The use of antimicrobials and coccidiostats in animal farming is of paramount concern with respect to human, animal and environmental contamination issues and as a source of resistant pathogenic bacteria. Still, most farmers use BL as ruminant feed and fertilizer without processing. Even though the effects of the stacking treatments on degradation of antimicrobials were significantly high, the degradation of coccidiostats and tilmicosin was limited. Clearly, BL should be treated and supervised before use as feed supplement or for land application. Hence, the present method, designed to support these goals, was optimized in terms of sensitivity and se-lectivity for the analytes addressed.

This paper focuses on robust multi-criteria traffic network equilibrium problems with path capacity constraints. The concepts of robust vector equilibrium and robust vector equilibrium with respect to worst case are introduced, respectively. To generate a subset of robust vector equilibrium, an equivalent min-max optimization problem is constructed. In addition, a direct search algorithm, in which the step size without derivatives and redundant parameters, for solving this min-max problem is proposed. To find a subset of robust vector equilibrium with respect to worst case, an equivalent smoothing optimization problem based on a variant version of ReLU activation function is established. Numerical experiments are also presented to expound the advantages of the algorithms.

Ion current rectification (ICR) is the ratio of ion current by forward bias to by backward bias and is a critical indicator of diode performance. In previous studies, many attempts have been continued to improve the performance of this ICR, but there is the intrinsic problem for geometric changes that induce ionic rectification due to their fabrication problem. Additionally, the high ICR could be achieved in the narrow salt concentration range only. Here, we propose a multi-layered bipolar ionic diode based on an asymmetric nanochannel network membrane (NCNM), which is realized by soft lithography and self-assembly of homogenous-sized nanoparticles. Owing to the freely changeable geometry based on soft lithography, the ICR performance can be explored according to the variation of microchannel shape. Interestingly, very stable ICR performance can be achieved using the multi-layered 3D configuration for the bipolar diode in a broad range of salt concentrations (0.1mM ~ 100 mM). This demonstrates the promising potential of multi-layered NCNM for applications in highly concentrated electrolytes, such as biosensors, desalination, or energy harvesting.

The environment is seldom optimal for plant growth and changes in abiotic and biotic signals, including temperature, water availability, radiation and pests, induce plant responses to optimise survival. The New Zealand native plant species and close relative to Arabidopsis thaliana, Pachycladon cheesemanii grows under environmental conditions that are unsustainable for many plant species. Here we compare the responses of both plant species to different stressors (low temperature, salt and UV-B radiation) to help understand how P. cheesemanii can grow in such harsh environments. The stress transcriptomes were then determined and comparative transcriptome and network analyses discovered similar and unique responses within species between different stresses, and between the two plant species. A number of widely studied plant stress processes were highly conserved in A. thaliana and P. cheesemanii. However, in response to cold stress, Gene Ontology terms related to glycosinolate metabolism were only enriched in P. cheesemanii. Salt stress was associated with alteration of the cuticle and proline biosynthesis in A. thaliana and P. cheesemanii, respectively. Anthocyanin production may be a strategy to cope with UV-B radiation stress in P. cheesemanii only. These results allowed us to construct broad stress response pathways in A. thaliana and P. cheesemanii and identify possible novel plant strategies that help mitigate environmental stress.

The genus Amphichorda has been recently re-erected as an independent linage from Beauveria, circumscribed within Cordycipitaceae. However, its phylogenetic relationships with other members of this family remain obscure. In our on-going efforts to expand the knowledge on the diversity of culturable ascomycetes from the Mediterranean Sea, we isolated several specimens of Amphichorda. Preliminary sequence analyses revealed great phylogenetic distance with accepted Amphichorda species and a close relation to Onychophora coprophila. Onychophora is a monotypic genus of enteroblastic conidiogenous cells, presumably related to Acremonium (Bionectriaceae); while Amphichorda exhibits holoblastic conidiogenesis. Here, we examine representative strains of Amphichorda species to resolve the taxonomy of the genus and the above-mentioned fungi combining morphological, ultrastructure and multi-locus phylogenetic analyses (ITS, LSU, tef1, BenA). The results revealed Amphichorda as a member of the Bionectriaceae, where its asexual morphs represent a transition between enteroblastic and holoblastic conidiogenesis for this group of fungi. We also describe and illustrate Amphichorda littoralis sp. nov., and propose the new combination Amphichorda coprophila. In addition, we stablish key phenotypic features to distinguish Amphichorda species and demonstrate the higher salt tolerance degree of A. littoralis, consistent with its marine origin. This work provides a comprehensive framework for future studies in the genus.

Alzheimer's disease (AD) is an incurable neurodegenerative disorder. Early screening, particularly in blood has been regarded as an effective approach for AD diagnosis and prevention. In addition, metabolic dysfunction has been demonstrated to be closely related to AD, which might be reflected in whole blood transcriptome. Hence, we hypothesized that establishment of diagnostic model based on metabolic signatures of blood is a workable strategy. To the end, we initially constructed metabolic pathway pairwise (MPP) signatures to characterize the interplay among metabolic pathways. Then, a series of bioinformatic methodologies, e.g., differential expression analysis, functional enrichment analysis, and network analysis, etc. were used to investigate the molecular mechanism behind AD. Moreover, an unsupervised clustering analysis based on the MPP signature profile via Non-Negative Matrix Factorization (NMF) algorithm was utilized to stratify AD patients. Finally, aimed at distinguishing AD patients from non-AD group, a metabolic pathway-pairwise scoring system (MPPSS) was established using multi-machine learning methods. As a result, many metabolic pathways correlated to AD were disclosed, including oxidative phosphorylation and fatty acid biosynthesis, etc. NMF clustering analysis divided AD patients into two subgroups (S1 and S2), which exhibit distinct activities of metabolism and immunity. Typically, oxidative phosphorylation in S2 exhibits a lower activity than that in S1 and non-AD group, suggesting the patients in S2 might possess a more compromised brain metabolism. Additionally, Immune infiltration analysis showed that the patients in S2 might have phenomena of immune suppression, compared with S1 and non-AD group. These findings indicated that S2 probably have a more severe progression of AD. Finally, MPPSS could achieve an AUC of 0.73 in training dataset, 0.71 in testing dataset and an AUC of 0.82 on weighted average in five external validation datasets. Overall, our study successfully established a novel metabolism-based scoring system for AD diagnosis using blood transcriptome, and provided new insight into the molecular mechanism of metabolic dysfunction implicated in AD.

Speech emotion recognition is a critical component for achieving natural human-robot interaction. The modulation-filtered cochleagram is a feature based on auditory modulation perception, which contains multi-dimensional spectral-temporal modulation representation. In this study, we propose an emotion recognition framework that utilizes a multi-level attention network to recognize emotions from the modulation-filtered cochleagram. The channel-level attention and spatial-level attention modules are used to capture emotional saliency maps of channel and spatial feature representations from the 3D convolution feature maps, respectively. Furthermore, the temporal-level attention module captures significant emotional regions from the concatenated feature sequence of the emotional saliency maps. Our experiments on the IEMOCAP dataset demonstrate that the modulation-filtered cochleagram significantly improves the prediction performance of categorical emotion compared to other evaluated features. Moreover, our emotion recognition framework achieves a better unweighted accuracy of 71% in categorical emotion recognition than several existing approaches in the experiments. In summary, our study demonstrates the effectiveness of the modulation-filtered cochleagram in speech emotion recognition, and our proposed multi-level attention framework provides a promising direction for future research in this field.

When the image quality is evaluated, the human visual system (HVS) infers the details in the image through its internal generative mechanism. In this process, the HVS integrates both local and global information of the image, utilizes contextual information to restore the original image information, and compares it with the distorted image information for image quality evaluation. Inspired by this mechanism, a no-reference image quality assessment method is proposed based on a multitask image restoration network. The multitask image restoration network generates a pseudo-reference image as the main task and produces structural similarity index measure map as an auxiliary task. By mutually promoting the two tasks, a higher quality pseudo-reference image is generated. In addition, when predicting the image quality score, both the quality restoration features and the difference features between the distorted and reference images are used, thereby fully utilizing the information from the pseudo-reference image. To enable the model to focus on both global and local features, a multi-scale feature fusion module is proposed. Experimental results demonstrate that the proposed method achieves excellent performance on both synthetically and authentically distorted databases.

In recent years, the ecological and economic values of forest plants have been gradually recognized worldwide. However, the growing global demand for new forest plant varieties with higher wood production capacity and better stress tolerance cannot be satisfied by conventional phenotype-based breeding, marker-assisted selection, and genomic selection. In the recent past, diverse omics technologies, including genomics, transcriptomics, epigenomics, proteomics, and metabolomics, have been developed rapidly, providing powerful tools for the precision genetic breeding of forest plants. Genomics lays a solid foundation for understanding complex biological regulatory networks, while other omics technologies provide different perspectives at different levels. Multi-omics integration has combined the different omics technologies, becoming a powerful tool for genome-wide functional element identification in forest plant breeding. This review summarizes the recent progress of omics technologies and their applications in the genetic studies of forest plants. It will provide forest plant breeders with an elementary knowledge of multi-omics techniques for future breeding programs.

Owing to the advantages of cost-effectiveness, compactness, and the avoidance of complicated camera synchronization, single-camera three-dimensional (3D) digital image correlation (DIC) techniques have gained increasing attention for deformation measurement of materials and structures. In the traditional single-camera 3D-DIC system, the left and right view images can be recorded by a single camera using a diffraction grating, a bi-prism or a set of planar mirrors. To further improve the measurement accuracy of single-camera 3D-DIC, this paper introduces a single-camera four-view imaging technique by installing a pyramidal prism in front of the camera. The 3D reconstruction of the measured points before and after deformation is realized with eight governing equations induced by four views, and the strong geometric constraints of four views can help to improve the measurement accuracy. A static experiment, a rigid body translation experiment and a four-point bending experiment show that the proposed single-camera 3D-DIC method can achieve higher measurement accuracy than the dual-view single-camera 3D-DIC techniques and has advantages in reducing both random error and systematic error.

In this study we present a hybrid approach of ACO with fuzzy logic and clustering methods to solve multi-objective path planning problems in case of swarm USVs. This study aims to enhance the performance of ACO algorithm by integrating fuzzy logic in order to cope with the multiple contradicting objectives and generate quality solutions by in parallel identifying the mission areas of each USV to reach the desired targets. The objectives that are taken into account are the minimization of traveled distance and energy consumption, and the maximization of path smoothness. A comparative evaluation is conducted among ACO and fuzzy inference systems, Mamdani (ACO-M) and Takagi–Sugeno–Kang (ACO-TSK). The results showed that depending on the needs of the application, each methodology can contribute respectively. ACO-M generates better paths but ACO-TSK presents higher computation efficiency.

This research work focuses on the potential application of an organic compound, santalol obtained from santalum album in the inhibition of the enzyme tyrosinase which is actively involved in the biosynthesis of the melanin pigment. Over-production of melanin causes undesirable pigmentation in humans as well as other organisms that significantly downgrade their aesthetic value. The study is designed to explain the purification of tyrosinase from the mushroom Agaricus bisporus, followed by activity assay and enzyme kinetic to give insight into the santalol modulated tyrosinase inhibition in a dose dependent manner. The multi-spectroscopic techniques like UV-vis, fluorescence, and isothermal calorimetry are employed to deduce the efficiency of santalol as potential candidate against the tyrosinase enzyme activity. Experimental results are further verified by molecular docking. Santalol derived from the essential oils of santalum album, is widely used as remedy for skin disorders and potion for fair complexion since ancient times. Based on enzyme kinetics and biophysical characterization, this is the first scientific evidence where santalol inhibits tyrosinase, which may be employed in agriculture, food, and cosmetic industries by prevent excess melanin formation or browning.

Cystic fibrosis (CF) is characterized by mutations of CFTR that lead to increased viscous secretions, bacterial colonization and recurrent infections. Chronic P. aeruginosa infection in persons with CF is associated with progressive and accelerated lung function decline despite aggressive antibiotic treatment. We report the management of respiratory infections in persons with CF with antibiotic therapy that was based on the recommendations of AtbFinder, a novel, rapid, culture-based diagnostic test system that employs a novel paradigm of antibiotic selection. AtbFinder mimics bacterial interactions with antibiotics at concentrations that can be achieved in affected tissues or organs, and models conditions of interbacterial interactions within polymicrobial biofilms. This open-label, single-arm, investigator‐initiated clinical study was designed to identify the efficacy of antibiotics selected using AtbFinder in persons with CF. Microbiological and clinical parameters were assessed following the change of antibiotic therapy to antibiotics selected with AtbFinder between January 2016 and December 2018 and retrospectively compared with clinical data collected between January 2013 and December 2015.We enrolled 35 persons with CF (33 with chronic P. aeruginosa colonization). Antibiotics selected using AtbFinder resulted in clearance of P. aeruginosa in 81.8% of subsequent cultures, decreased pulmonary exacerbations from 1.21 per patient per annum to 0, and an increase in predicted FEV1% up to 28.4% from baseline. The number of systemic antibiotic courses used in patients after switching to the AtbFinder selected therapy was reduced from 355 to 178. These findings describe the superiority of antibiotic regimens selected with AtbFinder compared with routine antimicrobial susceptibility testing.

Background: Physical activity has been considered as a promising approach to slow down the disease process in Multiple Sclerosis (MS) patients. While the functional impairments of MS have been studied in detail, but there is limited evidence of the efficacy of exercise interventions on the Multiple Sclerosis functional composite (MSFC) score in these patients. The study aim was to in-vestigate the improvement in MSFC score by multi-function swing suspension training (MFSST) in the women with MS. Methods: The patients were divided into the intervention and control groups. A total of 47 MS patients completed the MSFC components at baseline and after the intervention. Z scores were created for each test based on control means. Results: The MSFC components showed a significant increment in comparison with the baseline levels in the four, six, and eight weeks following the first exercise session (all p<0.05). These dif-ferences in the control group were not significant. The improvement in the MSFC score and the component Z-scores in the intervention groups was found from the fourth week onwards. Conclusions: The study findings highlight that MFSST can be used as an effective treatment method in MS patients due to its positive effects on physical parameters, such as muscles strength, functional impairments, and cognitive problems.

An electrocardiograph (ECG) reflects the health of the human heart and is used to help diagnose arrhythmia and myocardial infarction(MI) in clinical practice. Early diagnosis of arrhythmia helps implement preventive measures and plays a crucial role in saving a patient's life. With the increasing demand of clinicians for ECG analysis technology, intelligent detection and diagnosis of ECG signals has become a more efficient means to assist physicians in diagnosing cardiovascular diseases. This paper introduces an ECG diagnosis approach based on an ensemble deep learning combination of CNN(convolutional neural network) and SLAP(stacked-long short term memory architecture for prediction) architecture. ECG data is denoised and further divided into single heartbeats to achieve data standardization and sample diversity. Adam optimizer and BCEwithlogitsloss multi-classification loss function were used to enhance the model effect, and the system achieved the classification effect of 99.3% average accuracy, 99.0% F1-value, and 99.2% sensitivity in MIT-BIH standard database classification. It also shows good generalization ability on the Tianchi data set.

In the era of multi-omic sciences, dogma on singular cause-effect in physio-pathological processes is overcome and system biology approaches have been providing new perspectives to see through. In this context, extracellular vesicles (EVs) are offering a new level of complexity, given their role in cellular communication and their activity as mediators of specific signals to target cells or tissues. Indeed, their heterogeneity in terms of content, function, origin and potentiality contribute to the cross-interaction of almost every molecular process occurring in a complex system. Such features make EVs proper biological systems being, therefore, optimal targets of omic sciences. Currently, most studies focus on dissecting EVs content in order to either characterize it or to explore its role in various pathogenic processes at transcriptomic, proteomic, metabolomic, lipidomic and genomic levels. Despite valuable results are being provided by individual omic studies, the categorization of EVs biological data might represent a limit to be overcome. For this reason, a multi-omic integrative approach might contribute to explore EVs function, their tissue-specific origin and their potentiality. This review summarizes the state-of-the-art of EVs omic studies, addressing recent research on the integration of EVs multi-level biological data and challenging developments in EVs origin.

Some researchers in Taiwan argue that the current mechanism by which government subsidies are allocated for smart city demonstration projects warrants improvement. A comprehensive literature review determined that the development potential of smart cities should be prioritized in site selection for such demonstration projects. This study developed an evaluation framework on the basis of multi-criteria evaluation methods to enable the identification of suitable smart community demonstration sites. Evaluation criteria were first identified through the Delphi method. Next, the weights of each criterion were derived through the analytic hierarchy process. Furthermore, the capability of the proposed evaluation model was determined through simulation testing.

Energy system modelling is an essential practice to assist a set of heterogeneous stakeholders in the process of defining an effective and efficient energy transition. From the analysis of a set of open source energy system models, it has emerged that most models employ an approach directed at finding the optimal solution for a given set of constraints. On the contrary, a simulation model is a representation of a system that is used to reproduce and understand its behaviour under given conditions, without seeking an optimal solution. Given the lack of simulation models that are also fully open source, in this paper a new open source energy system model is presented. The developed tool, called Multi Energy Systems Simulator (MESS), is a modular, multi-node model that allows to investigate non optimal solutions by simulating the energy system. The model has been built having in mind urban level analyses. However, each node can represent larger regions allowing wider spatial scales to be be represented as well. MESS is capable of performing analysis on systems composed by multiple energy carriers (e.g. electricity, heat, fuels). In this work, the tool’s features will be presented by a comparison between MESS itself and an optimization model, in order to analyze and highlight the differences between the two approaches, the potentialities of a simulation tool and possible areas for further development.

Continuous and emerging advances in Information and Communication Technology (ICT) have enabled IoT-to-Cloud applications to be induced by data pipelines coupled with Edge Intelligence-based architectures. Advanced vehicular networks greatly benefit from these architectures due to the implicit functionalities that are focused on realizing the Internet-of-Vehicle (IoV) vision. However, IoV is susceptible to attacks, where adversaries can easily exploit existing vulnerabilities. Several attacks may succeed due to inadequate or weaker authentication techniques. Hence, there is a timely need for hardening the authentication process through cutting-edge access control mechanisms. This paper proposes a Blockchain-based Multi-Factor authentication model that uses an embedded Digital Signature (MFBC_eDS) for vehicular clouds and Cloud-enabled IoV. Our proposed MFBC_eDS model consists of a scheme that integrates the Security Assertion Mark-up Language (SAML) to the Single Sign-On (SSO) capabilities for a connected Edge-to Cloud ecosystem. MFBC_eDS draws an essential comparison with the baseline authentication scheme suggested by Karla and Sood. Based on the foundations of Karla and Sood’s scheme, an embedded Probabilistic Polynomial-Time Algorithm (ePPTA) and an additional Hash function for the Pi generated during Karla and Sood’s authentication are proposed and discussed. The preliminary analysis of the proposition shows that the approach is more suitable to counter major adversarial attacks in an IoV-centered environment based on Dolev-Yao adversarial model while satisfying aspects of the CIA triad.

Like traditional single label learning, multi-label learning is also faced with the problem of dimensional disaster.Feature selection is an effective technique for dimensionality reduction and learning efficiency improvement of high-dimensional data. In this paper, Logistic regression, manifold learning and sparse regularization were combined to construct a joint framework for multi-label feature selection (LMFS). Firstly, the sparsity of the eigenweight matrix is constrained by the $L_{2,1}$-norm. Secondly, the feature manifold and label manifold can constrain the feature weight matrix to make it fit the data information and label information better. An iterative updating algorithm is designed and the convergence of the algorithm is proved.Finally, the LMFS algorithm is compared with DRMFS, SCLS and other algorithms on eight classical multi-label data sets. The experimental results show the effectiveness of LMFS algorithm.

Our study provides guidelines on how to build long-term customer relationship in the non-contract mechanism context. More specifically, the findings show that special, social, and core benefits influence calculative commitment, and operational and special benefits influence affective commitment. This study also supports that calculative and affective commitment play a crucial role in understanding multi-channel agencies’ loyalty. In sum, this study revealed that calculative and affective commitment can be considered as partial or full mediators in the relationship between RBs (relational benefits) and loyalty. This study not only contributed to the existing SET (social exchange theory) and RBs paradigm but also provided practical implications for food distribution management.

In recent years, land supply in Hong Kong has fallen sharply and fails to keep pace with the growth of population and number of households. Land shortage becomes urgent and dire. With the inadequate provision of residential land, housing supply is also adversely affected.Insufficient housing supply leads to surging property and rental price in the private market. According to the Rating and Valuation Department (RVD), the overall private domestic price index peaked in June 2017 at 336.1. Keen housing demand is also observed in the private rental market. RVD statistics showed that the domestic rental index also reached the peak at 183.6 in June 2017 and the vacancy rate of about 3.8% as at the end-2016, which is much lower than the average vacancy rate of 5% from 1996 to 2015 (Development Bureau, 2017).In addition, there is soaring housing demand in public housing. As at the end-December 2021, the average waiting time for general applicants was 5.7 years, which is nearly double of the Housing Authority’s target for providing the first flat offer to general applicants at around three years on average (Housing Authority, 2021). Identifying and securing sufficient land to meet both current and anticipated pressing housing demand becomes a key challenge of the government. In the light of this, the government has established a dedicated task force (Task Force on Land Supply) in September 2017 and appointed 30 professionals from different disciplines, such as planning, engineering, academia and think tank, to take a Marco-review on the land supply sources, look for feasible options as well as consider the pros and cons of various options. 18 land supply options were worked out for the public to make choices in the public engagement exercise. Among the 18 choices, the development area on the Periphery of Country Parks was regarded as one of the land supplies sources. This option does not only include the Hong Kong Housing Society’s studies on developing Two Pilot Areas on the Periphery of Tai Lam and Man On Shan Country Parks, but also include developing more areas on the periphery of Country Parks. The proposed option received overwhelming attention from the public and aroused debates in various perspectives. Its ecological value, recreational value, financial viability and even legitimacy were discussed. However, spatial analysis on the suitability of having residential development in Country Parks has not been conducted. Therefore, in this study, multi criteria GIS analysis is conducted to evaluate the geographic suitability of Hong Kong Country Parks for residential purpose with the consideration of various criteria.

Distributed fiber optic vibration sensors based on Φ-OTDR using Rayleigh backscattering of highly coherent light source pulses are very popular type in the area of sensors due to many attractive features, mainly due to its distributed manner of sensing, i.e. they can operate as thousands of local sensors simultaneously. The paper summarizes and describes several important modifications of the original sensor scheme to enhance its key performance parameters and to extend its application potential. A multi-fiber sensor form was proposed. Single- and two-fiber sensors were designed, constructed and tested both in the laboratory and in a real environment. Variants of two-fiber sensor utilizing optical switches for the sensor flexibility enhancement are proposed and their applications are described.

Automatic Voice Query Service can extremely reduce the artificial cost, which could improve the response efficiency for users. The automatic speech recognition (ASR) is one of the important component in AVQS. However, many dialect areas in China make the AVQS have to response the multi-accented Mandarin users by single acoustic model in ASR. This problem severely limits the accuracy of ASR for multi-accented speech in the AVQS. In this paper, a new framework for AVQS is proposed to improve the accuracy of response. Firstly, the fusion feature including iVector and filterbank acoustic features is used to train the Transformer-CTC model. Secondly, the transformer-CTC model is used to construct the end-to-end ASR. Finally, key words matching algorithm for AVQS based on fuzzy mathematic theory is proposed to further improve the accuracy of response. The results show that the final accuracy in our proposed framework for AVQS arrives at 91.5%. The proposed framework for AVQS can satisfy the service requirement of different areas in mainland of China. This research has a great significance for exploring the application value of artificial intelligence in the real scene.

The production of butanol, acetone and ethanol by Clostridium acetobutylicum is a biphasic fer-mentation process. In the first phase the carbohydrate substrate is metabolized to acetic and bu-tyric acid, in the following second phase the product spectrum is shifted towards the economi-cally interesting solvents. Here we present a cascade of six continuous stirred tank reactors (CCSTR), which allows performing the time dependent metabolic phases of an ace-tone-butanol-ethanol (ABE) batch fermentation in a spatial domain. Experimental data of steady states under four operating conditions - with variations of the pH in the first bioreactor between 4.3 and 5.6 as well as the total dilution rate between 0.042 1/h and 0.092 1/h - were used to optimize and validate a corresponding mathematical model. Beyond a residence time distribution representation and substrate, biomass and product kinetics this model also includes the differen-tiation of cells between the metabolic states. Model simulations predict a final butanol product concentration of 8.2 g/L and a butanol productivity of 0.75 g/(L h) in the CCSTR operated at a pH in bioreactor 1 of 4.3 and D = 0.092 1/h, while 31 % of the cells are differentiated to the solventogenic state. Aiming at an enrichment of solvent-producing cells, a feedback loop was introduced into the cascade - sending cells from a later state of the process (bioreactor 4) back to an early stage of the process (bioreactor 2). In agreement with the experimental observations, the model accurately predicted an increase of butanol formation rate in bioreactor stages 2 and 3, resulting in an overall butanol productivity of 0.76 g/(L h) for the feedback loop cascade. The here presented CCSTR and the validated model will serve to investigate further ABE fermentation strategies for a controlled metabolic switch.

The potential yield of annual crops is affected by management practices and water and energy availabilities throughout the crop season. The current work aimed to assess the effects of plant population and soil covering on yield components of maize. Field experiments were carried out during 2014-15 and 2015-16 growing seasons at areas grown with oat straw, voluntary plants and bare soil, considering five different plant populations (40,000, 60,000, 80,000, 100,000 and 120,000 plants ha-1) and three sowing dates (15 Sep., 30 Oct., 15 Dec.) for the hybrid P30F53YH in Ponta Grossa, State of Parana, Brazil. Non-impacts of soil covering or plant population on plant height at the flowering phenological stage were observed. Significant effects of soil covering on crop physiological and yield components responses throughout the 2014-15 season were detected. Influence of plant populations on yield components was evidenced, suggesting that from 80,000 plants ha-1 the P30F53YH hybrid performs a compensatory effect among assessed yield components in such a way as to not compromise productivity insofar as plant population increases up to 120,000 plants ha-1. It was noticed a positive trend of yield components and crop final yield as a function of plant density increments.

A photovoltaic-thermal (PVT) collector is a solar-based micro-cogeneration system which generates simultaneously heat and power for buildings. The novelty of this paper is to conduct energy and exergy analysis on PVT collector performance under two different European climate conditions. The performance of the PVT collector is compared to a PV panel. Finally, the PVT design is optimized in terms of thermal and electrical exergy efficiencies. The optimized PVT designs are compared to the PV panel performance as well. The main focus is to find out if the PVT is still competitive with the PV panel electrical output, after maximizing its thermal exergy efficiency. The PVT collector is modelled into Matlab/Simulink to evaluate its performance under varying weather conditions. The PV panel is modelled with the CARNOT toolbox library. The optimization is conducted using Matlab gamultiobj-function based on Non-Dominated Sorting Genetic Algorithm-II (NSGA-II). The results indicated 7.7% higher annual energy production in Strasbourg. However, the exergy analysis revealed a better quality of thermal energy in Tampere with 72.9% higher thermal exergy production. The electrical output of the PVT is higher than from the PV during the summer months. The thermal exergy- driven PVT design is still competitive compared to the PV panel electrical output.

Nowadays, many political campaigns are using social influence (SI) in order to convince voters to support/oppose a specific candidate/party. In election control via SI problem, an attacker tries to find a set of limited influencers to start disseminating a political message in a social network of voters. A voter will change his opinion when he receives and accepts the message. In constructive case, the goal is to maximize the number of votes/winners of a target candidate/party, while in destructive case, the attacker tries to minimize them. Recent works considered the problem in different models and presented some hardness and approximation results. In this work, we consider multi-winner election control through SI on different graph structures and diffusion models, and our goal is to maximize/minimize the number of winners in our target party. We show that the problem is hard to approximate when voters' connections form a graph, and the diffusion model is the linear threshold model. We also prove the same result considering an arborescence under independent cascade model. Moreover, we present a dynamic programming algorithm for the cases that the voting system is a variation of straight-party voting, and voters form a tree.

Acetyleugenol is a phytochemical compound with broad effect against infectious diseases and tumors. Here, we extracted, characterized and elucidated the structure of acetyeugenol, for the first time, from the leaves of Acacia nilotica (L.)―a well-known medicinal plant. The broad antibacterial potential of acetyleugenol was first confirmed against seven bacterial pathogenic isolates with best activity against Proteus sp., Salmonella typhi, Staphylococcu aureus, and Streptococcus pneumonia, which showed similar or better zone of inhibition to that of the control amoxicillin. To further investigate its effect against Mycobacterium tuberculosis, acetyleugenol and its indole and phenyl analogs were subjected to molecular docking experiments against two potential tuberculosis drug targets―MtPknE and MtPknB Ser/Thr protein kinases. The results reveal that all of the analogs have improved docking scores comparing to the acetyleugenol. The indole analogs EUG-1 and EUG-3 were more effective with better docking scores for MtPknE with –11.08 and –10.05 kcal/mol, respectively. Similar results were obtained for the MtPknB. In contrast, only the EUG-2 phenyl analog has given rise to similar docking scores for both targets. This opens the door for further comprehensive studies on these acetyleugenol analogs with in vitro and in vivo experiments to validate and get more insights into their mechanisms of action.

Diabetes mellitus (DM) is one of the major risk factors for COVID-19 complications as it is one of the chronic immune-compromising conditions especially if patients have uncontrolled diabetes, poor HbA1c &/or irregular blood glucose levels. Diabetic patient’s mortality rates with COVID-19 are higher than cardiovascular or cancer patients. Recently Bacillus Calmette–Guérin (BCG) has shown successful results in reversing diabetes in both rats and clinical trials based on different mechanisms from aerobic glycolysis to Beta cells regeneration. BCG is a multi-face vaccine that has been used extensively in protection from TB and leprosy and has been repositioned for treatment of bladder cancer, diabetes & multiple sclerosis. Recently, the COVID-19 epidemiological study confirmed that universal BCG vaccination reduced morbidity and mortality in certain geographical areas. Countries without universal policies of BCG vaccination (Italy, Nederland, USA) have been more severely affected compared to countries with universal and long-standing BCG policies that have shown low numbers of reported COVID-19 cases. Some countries have started clinical trials that included a single dose BCG vaccine as prophylaxis from COVID-19 or an attempt to minimize its side effects. This proposed research aims to use BCG vaccine as a double-edged weapon countering both COVID-19 & diabetes, not only as protection but also as therapeutic vaccination. The work includes a case study of regenerated pancreatic beta cells based on improved C-peptide & PCPRI laboratory findings after BCG vaccination for a 9 years’ patient. The patient was re-vaccinated based on a negative tuberculin test & no scar at the site of injection of the 1st BCG vaccination at birth. Furthermore, the authors in the present article described a prospective BCG multi-dose clinical study in full details that they will apply in case of acceptance of their submitted grant & the ethical committee approval. The aim of the clinical study is to check if double dose BCG (4 weeks apart) will show a significant difference in the protection of health care professionals in Egypt. The authors suggest and invite the scientific community to take into consideration the concept of direct BCG re-vaccination (after 4 weeks) because of the reported gene expressions & exaggerated innate immunity consequently. As the diabetic MODY-5 patient (mutation of HNF1B, Val2Leu) was on low dose Riomet® while eliminating insulin gradually, a simple analytical method for metformin assay was recommended to ensure its concentration before use as it is not approved yet by the Egyptian QC labs.

The need to understand the process by which particles, including solar wind and coronal ions as well as pickup ions, are accelerated to high energies (ultimately to become anomalous cosmic rays) motivate a multi-fluid shock wave model which includes kinetic effects (e.g. ion acceleration) in an electromagnetically self-consistent framework. Particle reflection at the cross-shock potential leads to ion acceleration in the motional electric field and thus anisotropic heating and pressure in the shock layer, with important consequences for the multi-fluid dynamics. This motivates development of a multi-fluid model of solar wind electrons and ions treated as fluid, coupled self-consistently with a small population of kinetically treated ions (e.g. pickup ions.) Consideration of both the time dependent and steady state regimes, indicate that such a multi-fluid approach is necessary for resolving the, Debye scale, particle reflecting cross-shock potential and subsequent dynamics. To study charge separation effects in narrow, supersonic wave layers we consider a reduction of the system to the steady state for cold ions and hot electrons and find two types of solitary waves inherent to the reduced two-fluid system in this limiting case.

Industry 4.0 is having a great impact in all smart efforts. This is not a single product, but is composed of several technologies, being one of them Industrial Internet of Things (IIoT). Currently, there are very varied implementation options offered by several companies, and this imposes a new challenge to companies that want to implement IoT in their processes. This challenge suggests to use multi-criteria analysis to make a repeatable and justified decision, requiring a set of alternatives and criteria. This paper proposes a new methodology and comprehensive criteria to help organizations to take an educated decision by applying multi-criteria analysis. Here, we suggest a new original use of PROMETHEE-II with full example from weight calculation up to IoT platform selection, showing this methodology as an effective study for other organizations interested to select an IoT platform. The criteria proposed outstands from previous work by including not only technical aspects, but economic and social criteria, providing a full view of the problem analyzed. A case of study was used to prove this proposed methodology.

Internet of things (IoT) is a network of smart things. This indicates the ability of these physical things to transfer information with other physical things. IoT has introduced various services and daily human life depends on its reliable and accessible operation. The characteristics of these networks, such as topology dynamicity and energy constraint, challenges the routing problem in these networks. Previous routing methods could not achieve the required performance in this type of network. Therefore, developers of this network designed and developed specific methods in order to satisfy the requirements of these networks. One of the routing methods is utilization of multi-path protocols which send data to its destination using routs with separate links. One of such protocols is AOMDV routing protocol. AOMDV protocol is a multi-path protocol which uses multiple different paths for sending information in order to maintain the network traffic balance, manage and control node energy, decrease latency, etc. In this paper, this method is improved using gray system theory which chooses the best paths used for separate routes to send packets. To do this, AOMDV packet format is altered and some fields are added to it so that energy criteria, link expiration time, and signal to noise ratio can also be considered while selecting the best route. The proposed method named GSTMPR-IoT is introduced which chooses the routs with highest rank for concurrent transmission of data, using a specific routine based on the gray system theory. In order to evaluate and report the results, the proposed GSTMPR-IoT method is compared to the EECRP and AOMDV approaches with regard to throughput, packet delivery rate, end to end delay, average residual energy, and network lifetime. The results demonstrate the superior performance of the proposed GSTMPR-IoT compared to the EECRP and AOMDV approaches.

The immunomodulatory behaviour of the CCR6/CCL20 axis in multi -system pathophysiology and molecular signalling was investigated at two clinically significant time points, using a Ccr6 - deficient mouse model of spontaneous colitis. Four groups of mice, (C57BL/6J, Ccr6^-/- of C57BL/6J, Winnie x Ccr6 ^-/- and Winnie) were utilized and (I) colonic clinical parameters (2) histology of colon, spleen, kidney and liver (3) T and B lymphocyte distribution in the spleen and MLN by flowcytometry (5) colonic CCL20, phosphorylated PI3K and phosphorylated Akt expression by immunohistochemistry and (6) colonic cytokine expression by RT-PCR were evaluated. CCR6 deficiency was shown to attenuate inflammation in the spleen, liver and gut while renal histology remained unaffected. Marked focal lobular inflammation with reactive nuclear features were observed in hepatocytes and a significant neutrophil infiltration in red pulp with extra medullary hemopoiesis in the spleen existed in Winnie. These changes were considerably reduced in Winnie x Ccr6^-/- with elevated goblet cell numbers and mucus production in the colonic epithelium. Results indicate that Ccr6- deficiency in the colitis model contributes towards resolution of disease. Our findings demonstrate an intricate networking role for CCR6 in immune activation, which is downregulated by Ccr6 deficiency, and could provide newer clinical therapies in colitis.

In this paper we show how to efficiently implement parallel discrete simulations on Multi-Core and GPU architectures through a real example of application: a cellular automata model of laser dynamics. We describe the techniques employed to build and optimize the implementations using OpenMP and CUDA frameworks. We have evaluated the performance on two different hardware platforms that represent different target market segments: high-end platforms for scientific computing, using an Intel Xeon Platinum 8259CL server with48cores and also an NVIDIA Tesla6V100 GPU, both running on Amazon Web Server (AWS) Cloud, and on a consumer-oriented platform, using an Intel Core i9 9900k CPU and an NVIDIA GeForce GTX 1050 TI GPU. Performance results are compared and analysed in detail. We show that excellent performance and scalability can be obtained in both platforms, and we extract some important issues that imply a performance degradation for them. We also found that current Multi-Core CPUs with large core numbers can bring a performance very near to that of GPUs, even similar in some cases.

This study presents a path planning method for a mobile robot to be effectively operated through a multi-objective decision-making problem. Specifically, the proposed Fuzzy analytic hierarchy process (FAHP) determines an optimal position as a sub-goal within the multi-objective boundary. The key features of the proposed FAHP are evaluating the candidates according to the fuzzified relative importance among objectives to select an optimal solution. In order to incorporate FAHP into path planning, an AHP framework is defined, which includes the highest level (goal), middle level (objectives), and the lowest level (alternatives). The distance to the target, robot’s rotation, and safety against collision between obstacles are considered as objective functions. Comparative results obtained from the artificial potential field and AHP/FAHP simulations show that FAHP is much preferable for the mobile robot’s path planning than typical AHP.

Two desirable functions of healthy soil are nutrient cycling and pest suppression. We review recent literature on the contributions of soil microarthropods to soil health through their intersecting roles in decomposition and nutrient cycling and direct and indirect suppression of plant pests. Microarthropods can impact soil and plant health directly by feeding on pest organisms or serving as alternate prey for larger predatory arthropods, and indirectly, by mediating the ability of crop plants to resist or tolerate insect pests and diseases through interactions with the decomposition food web in support of plant nutrition. Soil fauna, including microarthropods, are key regulators of decomposition at local scales but their role at larger scales is unresolved. Future research priorities include the incorporation of multi-channel omnivory into food web modeling and understanding the vulnerability of our soil carbon to increased global temperatures.

This paper details the evolution of access network sharing models from legacy DSL to the most recent fibre-based technology and the main challenges faced from a technical and business perspectives. We first give an overview of existing access sharing models, that span physical local loop unbundling and virtual unbundled local access. We then describe different types of optical access technologies and highlight how they support network sharing. Next, we examine how the concept of SDN and network virtualization has been pivotal in enabling the idea of “true multi-tenancy”, through the use of programmability, flexible architecture and resource isolation. We give examples of recent developments of cloud central office and OLT virtualization. Finally, we provide an insight into the role that novel business models, such as blockchain and smart contract technology, could play in 5G networks. We discuss how these might evolve, to provide flexibility and dynamic operations that are needed in the data and control planes.

The growth of demand for metallic minerals has faced with the need for new techniques and improving technologies for all mine life cycle operations. Nowadays, the exploitation of old tailings and mine wastes facilities could represent a solution to this demand, with economic and environmental advantages. W-Sn Panasqueira Mine has been operating for more than 100 years. Its first processing plant “Rio” was located near Zêrere river being the mineral processing residues deposited on the top hillside on the margin of this river in Cabeço do Pião tailings dam. The lack of maintenance and monitoring of this enormous structure in the last twenty years represents high risks to the environment and population of the surrounding region. The re-mining of the tailings by hydrometallurgical methods was considered, in order to satisfy these two enounced conditions - metals demand and environmental risk, aiming for the sale of the metal to pay the environmental intervention. Field samples campaign allowed collecting data and results from laboratory tests driving to use regression optimization. The re-mining solution was studied, taking into account the technical, economic, social, and environmental aspects.

The combination of new-generation information technology and manufacturing technology has resulted in major and profound impact on future development paradigm of manufacturing. It is challenging for existing methods to conduct a multidimensional trend exploration related to machine tool domain, which is the basis of virtually everything in manufacturing. In this paper, we proposed an integrating approach framework combined topic models, bibliometric, trend analysis and patent analysis to mine insightful information about future development from multi-source data related to machine tool, such as papers, grants, patents and news. Specifically, papers and grants provided two different perspectives to explore the current focuses and future trends in machine tool research. Furthermore, the future technology development of machine tool was investigated through patents analysis. Finally, news related to machine tool industry in recent years was analyzed to analyze future machine tool business mode. The integration of the above various analytical methods and the multi-dimensional mining of literatures enabled the analysis of the future development of machine tool domain systematically from multi-perspectives which include research, technology development and industry. The conclusions obtained in this paper is beneficial to different communities of machine tool in terms of determining the research directions for researchers, identifying industry opportunities for corporations and developing reasonable industry policy for policy makers.

For the task planning problem of the command and control architecture, the existing algorithms have problems such as low efficiency and poor re-planning quality under abnormal conditions. Based on the requirements of the current accusation architecture, this paper constructs a distributed command and control architecture model based on multi-agents, which makes use of the superiority of multi-agents in dealing with complex tasks. The concept of MultiAgents-HTN is proposed under the framework. The original hierarchical task network planning algorithm is optimized, the multi-agent collaboration framework is redefined, and the coordination mechanism of local conflict is designed. Taking the classical resource scheduling problem as the experimental background, the comparison between the proposed algorithm and the classical HTN algorithm is carried out. The experimental results show that the proposed algorithm has higher quality and higher efficiency than the existing algorithm, and the space anomaly is heavy during processing. The planning is more efficient, and the time is more complicated and superior in dealing with the same problem, with good convergence and adaptability. The conclusion proves that the distributed command and control architecture proposed in this paper has high practicability in related fields and can solve the problem of distributed command and control architecture in multi-agent environment.

In this paper, we propose a novel approach of video skimming by exploiting the fusion of video temporal information and keyword information representation extracted from multi-model video information including audio, text and visual indices. In addition, we introduce the brand-safe filtering and sentiment analysis in order to only reserve the user-friendly content in the video skim. In the experiment by using the videos from YouTube-8M dataset, we have proved that the semantic conservation in the video skim from the proposed approach highly outperforms the approaches by only partial information of the video in conserving the semantic content of the video.

The electrocardiogram (ECG) was the first biomedical signal where digital signal processing techniques were extensively applied. By its own nature, the ECG is typically a sparse signal, composed of regular activations (the QRS complexes and other waveforms, like the P and T waves) and periods of inactivity (corresponding to isoelectric intervals, like the PQ or ST segments), plus noise and interferences. In this work, we describe an efficient method to construct an overcomplete and multi-scale dictionary for sparse ECG representation using waveforms recorded from real-world patients. Unlike most existing methods (which require multiple alternative iterations of the dictionary learning and sparse representation stages), the proposed approach learns the dictionary first, and then applies an efficient sparse inference algorithm to model the signal using the learnt dictionary. As a result, our method is much more efficient from a computational point of view than other existing methods, thus becoming amenable to deal with long recordings from multiple patients. Regarding the dictionary construction, we locate first all the QRS complexes in the training database, then we compute a single average waveform per patient, and finally we select the most representative waveforms (using a correlation-based approach) as the basic atoms that will be resampled to construct the multi-scale dictionary. Simulations on real-world records from Physionet's PTB database show the good performance of the proposed approach.

Tissue engineering is an emerging field of research due to its growing impact on the regeneration of tissue injured from damage and organ failure. Small hydrogel microspheres containing regenerative cells and stimulators can be used as building blocks to regenerate tissue by injecting them into damaged areas; a microneedle is used to minimize the incision and any associated infections. To address the need for production of a large number of microspheres for use in tissue engineering, we developed a 3D coaxial multi-nozzle flow-focusing device fabricated via a simple 3D-printing method that demonstrates a high rate of microsphere production per nozzle. This device has six coaxial microscale nozzles that produce hydrogel microspheres. Two individual parts—the inlet and nozzle—can be made separately by a 3D printer and bonded together using uncured photo-curable resin as glue. The dimensions of the microspheres are between 100 μm and 1200 μm. They are produced by adjusting the flow rate ratio between the dispersed and continuous media. A flow rate ratio of 180 demonstrated the highest microsphere production rate of 2.12e+5 microspheres per sec (0.25 mL/min). This microsphere production rate per nozzle is four times higher than that of currently available devices.

The paper analyses how between 1956 and 2009 the agrarian metabolism of the Barcelona Metropolitan Region (BMR) has become less functional, losing circularity in biomass flows and in relationship to its landscape. We do so by adopting a Multi-EROI and flow-fund (MuSIASEM) analyses and its nexus with landscape functional structure. The study of agricultural flows of Final Produce, Biomass Reused and External Inputs is integrated with that of land use, livestock, power capacity and population changes between 1956 (at the beginning of the Green Revolution) and 2009 (fully industrialized agriculture). A multi-scale analysis is conducted at the landscape scale (seven districts within the Barcelona metropolitan region) as well as for the functions deployed, within an agroecosystem, by the mutual interactions between its funds (land-uses, livestock and farming population). A complex nexus between land, livestock, dietary patterns and energy needs is shown; we conclude that from the perspective of the circular bioeconomy the agrarian sector has gone worse hand in hand with the landscape functional structure. Therefore, a novel perspective in landscape agroecology is opened

This study shows the application of self-organizing maps (SOMs) to probabilistic forecasts of wind power generation and ramps in Japan. SOMs are applied to atmospheric variables obtained from atmospheric reanalysis over the region, thus deriving classified weather patterns (WPs). Probabilistic relationships are established between the synoptic-scale atmospheric variables over East Japan and the generation of regionally integrated wind power in East Japan. Medium-range probabilistic wind power predictions are derived by SOM, as analog ensembles based on the WPs of the multi-center ensemble forecasts. As this analog approach handles stochastic uncertainties effectively, probabilistic wind power forecasts are rapidly generated from a very large number of forecast ensembles. The use of a multi-model ensemble provides better results than a one-forecast model. The hybrid ensemble forecasts further improve the probabilistic predictability skill of wind power generation, as compared with non-hybrid methods. It is expected that long-term wind forecasts will provide better guidance to transmission grid operators. The advantage of this method is that it can include an interpretative analysis of meteorological factors for variations in renewable energy.

Physical frailty and sarcopenia (PF&S) are hallmarks of aging that share a common pathogenic background. Perturbations in protein/amino acid metabolism may play a role in the development of PF&S. In this preliminary study, 68 community-dwellers aged 70 years and older, 38 with PF&S and 30 non-sarcopenic, non-frail controls (nonPF&S), were enrolled. A panel of 37 serum amino acids and derivatives was assayed by UPLC-MS. Partial Least Squares Discriminant Analysis (PLS-DA) was used to characterize the amino acid profile of PF&S. The optimal complexity of the PLS-DA model was found to be three latent variables. The proportion of correct classification was 76.6 ± 3.9% (75.1 ± 4.6% for enrollees with PF&S; 78.5 ± 6.0% for controls). Older adults with PF&S were characterized by higher levels of asparagine, aspartic acid, citrulline, ethanolamine, glutamic acid, sarcosine, and taurine. The profile of nonPF&S individuals was defined by higher levels of α-aminobutyric acid and methionine. Distinct profiles of circulating amino acids and derivatives characterize older individuals with PF&S. The dissection of these patterns may provide novel insights into the role played by protein/amino acid perturbations in the disabling cascade and possible new targets for interventions.

Wireless Sensor Networks (WSN) is designed to collect information across a large number of limited battery sensor nodes. Therefore, it is important to minimize the energy consumption of each node, which leads to the extension of the network life. Our goal is to design an intelligent WSN that collects as much information as possible to process it intelligently. To achieve this goal, an agent has been migrated to each node in order to process the information and to cooperate with these neighboring nodes while Mobile Agents (MA) can be used to reduce information between nodes and send those to the base station (Sink). This work proposes to use communication architecture for wireless sensor networks based on the Multi Agent System (MAS) to ensure optimal information collection. The collaboration of these agents generates a simple message that summarizes the important information in order to transmit it by a mobile agent. To reduce the size of the MA, the nodes of the network have been grouped into sector. As for each MA, we have established an optimal itinerary, consuming a minimum amount of energy with the data aggregation efficiency in a minimum time. Successive simulations in large scale wireless sensor networks through the SINALGO simulator show the performance of our proposal, in terms of energy consumption and package delivery rate.

The activity of prioritizing software requirements should be done as efficiently as possible. Selecting the most stable requirements for the most important customers for the development company can be a positive factor when we consider that the available resource does not always encompass the implementation of all requirements. Quantitative methods for reaching software prioritization in releases are many in the field of Search-Based Software Engineering (SBSE). However, we show that it is possible to use qualitative Verbal Decision Analysis (VDA) methods to solve this same type of problem. Moreover, we will use the ZAPROS III-i methods to prioritize requirements considering the opinion of the decision-maker, who will participate in this process. Finally, the results obtained in the VDA structured methods were quite satisfactory when compared to the methods using SBSE. A comparison of results between quantitative and qualitative methods will be made and discussed later.

Landing is one of the most dangerous tasks in all the operations on the aircraft carrier, and the landing safety is very important to the pilot and the flight deck operation. The problem of landing path selection is studied in this paper as there several candidates corresponding to different situations. A fuzzy path selection strategy is proposed to solve the problem considering the fuzziness of environmental information and human judgment, and the goal is to provide the pilot with more reasonable decision. The strategy is based on Fuzzy Multi-attribute Group Decision Making (FMAGDM), which has been widely used in industry. Firstly, the background of the path selection problem is given. Then the essential elements of the problem are abstracted to build the conceptual model. A group decision-making method is applied to denote the preference of each decision maker for each alternative route, and the optimal landing path under the current environment is determined taking into account the knowledge and the weight of both decision makers. Experimental studies under different setups, i.e., different environments, are carried out. The results demonstrate that the proposed path selection strategy is validated in different environments, and the optimal landing paths corresponding to different environments can be determined.

The eddy current loss should be optimized to be as less as possible for the stability of permanent magnet in high speed permanent magnet synchronous motor (HSPMSM) rotor and ensure the high efficiency and low temperature of the motor. This paper analyzes the eddy current distribution in rotor, with consideration of the conflict of the thickness of sleeve and diameter of the rotor, calculating the eddy current loss (ECL) and the thermal distribution via Separation of variables method for solving Maxwell's equations with analytical hieratical model of ECL constructed. The optimization result of ECL of the HSPMSM whose power and rated speed is 30kw 48000r/min can be got by multi-objective optimization method, combined weighting coefficient method and traversal algorithm based on chaotic local search particle swarm optimization (CLSPSO), utilizing ECL analytical model and other analytical constraints. Related experiment and measurement has been implemented with new approach of loss separation.

The planning of rural land depends to a large extent on the agrarian and forestry development model agreed upon for it. Within the framework of agrarian multifunctionality, to evaluate different development alternatives and their effect on territorial planning, its multiple dimensions must be considered as well as the interests and needs of the stakeholders. This work thus addresses the comprehensive evaluation of development alternatives for the rural area of a municipality of the Basque Country (Spain) through the implementation of a multi-criteria evaluation method with social participation. The results show, firstly, the existence of trade-offs between the functions to be promoted in the various development models evaluated. Secondly, the results indicate the need to reverse recent trends in the sector and the convenience of moving towards an agro-livestock model of greater ecological and local character, independently of the followed forest model. In fact, the evaluation carried out also reveals, thirdly, the existence of more or less latent conflicts, in particular with regards to forest policy.

This paper presents a multi-swarm PSO algorithm for the Quadratic Assignment Problem (QAP) implemented on the OpenCL platform. Our work was motivated by results of time efficiency tests performed for single-swarm algorithm implementation that showed clearly that the benefits of a parallel execution platform can be fully exploited provided the processed population is large. The described algorithm can be executed in two modes: with independent swarms or with migration. We discuss the algorithm construction as well as we report results of tests performed on several problem instances from the QAPLIB library. During the experiments the algorithm was configured to process large populations. This allowed us to collect statistical data related to values of goal function reached by individual particles. We use them to demonstrate on two test cases that although single particles seem to behave chaotically during the optimization process, when the whole population is analyzed, the probability that a particle will select a near-optimal solution grows.

Surface damage on honeycomb aircraft panels is often measured manually, and is therefore subject to variation based on inspection personnel. Eddy current testing (ECT) is sensitive to variations in probe-to-specimen spacing, or lift-off, and is thus promising for high resolution profiling of surface damage on aluminum panels. Lower frequency testing also allows inspection through the face sheet, an advantage over optical 3D scanning methods. This paper presents results from the ECT inspection of surface damage on an approximately flat aluminum honeycomb aircraft panel, and compares the measurements to those taken using optical 3D scanning technology. An ECT C-Scan of the dented panel surface was obtained by attaching the probe to a robotic scanning apparatus. Data was taken simultaneously at four frequencies of 25, 100, 400 and 1,600 kHz. A reference surface was then defined that approximated the original, undamaged panel surface, which also compensated for the effects of specimen tilt and thermal drift within the ECT instrument. Data was converted to lift-off using height calibration curves developed for each probe frequency. A damage region of 22,550 mm² area with dents ranging in depth from 0.13-1.01 mm was analyzed. The method was accurate at 1,600 kHz to within 0.05 mm (2s) when compared with 231 measurements taken via optical 3D scanning. Testing at 25 kHz revealed a 3.2 mm cell size within the honeycomb core, which was confirmed via destructive evaluation. As a result, ECT demonstrates potential for implementation as a method for rapid in-field aircraft panel surface damage assessment.

Satellite scene classification is challenging because of the high variability inherent in satellite data. Although rapid progress in remote sensing techniques has been witnessed in recent years, the resolution of the available satellite images remains limited compared with the general images acquired using a common camera. On the other hand, a satellite image usually has a greater number of spectral bands than a general image, thereby permitting the multi-spectral analysis of different land materials and promoting low-resolution satellite scene recognition. This study advocates multi-spectral analysis and explores the middle-level statistics of spectral information for satellite scene representation instead of using spatial analysis. This approach is widely utilized in general image and natural scene classification and achieved promising recognition performance for different applications. The proposed multi-spectral analysis firstly learns the multi-spectral prototypes (codebook) for representing any pixel-wise spectral data, and then based on the learned codebook, a sparse coded spectral vector can be obtained with machine learning techniques. Furthermore, in order to combine the set of coded spectral vectors in a satellite scene image, we propose a hybrid aggregation (pooling) approach, instead of conventional averaging and max pooling, which includes the benefits of the two existing methods but avoids extremely noisy coded values. Experiments on three satellite datasets validated that the performance of our proposed approach is much more accurate than even the deep learning framework for spatial analysis.

This paper deals with a generic methodology to evaluate the magnetic parameters of contactless power transfer systems. Neumann's integral has been used to create a matrix method that can model the magnetics of single coils (circle, square, rectangle). The principle of superposition has been utilised to extend the theory to multi-coil geometries such as double circular, double rectangle and double rectangle quadrature assuming linearity of magnetics. Numerical and experimental validation has been performed to validate the analytical models developed. A rigorous application of the analysis has been carried out to study misalignment and hence the efficacy of various geometries to misalignment tolerance. Comparison of single-coil and multi-coil shapes considering coupling variation with misalignment, power transferred and maximum efficiency is carried out.

Face verification for unrestricted faces in the wild is a challenging task. This paper proposes a method based on two deep convolutional neural networks(CNN) for face verification. In this work, we explore to use identification signal to supervise one CNN and the combination of semi-verification and identification to train the other one. In order to estimate semi-verification loss at a low computation cost, a circle, which is composed of all faces, is used for selecting face pairs from pairwise samples. In the process of face normalization, we propose to use different landmarks of faces to solve the problems caused by poses. And the final face representation is formed by the concatenating feature of each deep CNN after PCA reduction. What's more, each feature is a combination of multi-scale representations through making use of auxiliary classifiers. For the final verification, we only adopt the face representation of one region and one resolution of a face jointing Joint Bayesian classifier. Experiments show that our method can extract effective face representation with a small training dataset and our algorithm achieves 99.71% verification accuracy on LFW dataset.

The study of different forms of preconditioners for solving a system of nonlinear equations, by using Newton’s method, is presented. The preconditioners provide numerical stability and rapid convergence with reasonable computation cost, whenever chosen accurately. Different families of iterative methods can be constructed by using a different kind of preconditioners. The multi-step iterative method consists of a base method and multi-step part. The convergence order of base method is quadratic and each multi-step add an additive factor of one in the previously achieved convergence order. Hence the convergence of order of an m-step iterative method is m + 1. Numerical simulations confirm the claimed convergence order by calculating the computational order of convergence. Finally, the numerical results clearly show the benefit of preconditioning for solving system of nonlinear equations.

We present information theoretic search strategies for single and multi-robot teams to localize the source of biochemical contaminants in turbulent flows. The robots synthesize the information provided by sporadic and intermittent sensor readings to optimize their exploration strategy. By leveraging the spatio-temporal sensing capabilities of a mobile sensing network, our strategies result in control actions that maximize the information gained by the team while optimizing the time spent localizing the position of the biochemical source. By leveraging the team's ability to obtain simultaneous measurements at different locations, we show how a multi-robot team is able to speed up the search process resulting in a collaborative information theoretic search strategy. We validate our proposed strategies in both simulations and experiments.

Scene classification plays an important role in the intelligent processing of high-resolution satellite (HRS) remotely sensed image. In HRS image classification, multiple features, e.g. shape, color, and texture features, are employed to represent scenes from different perspectives. Accordingly, effective integration of multiple features always results in better performance compared to methods based on a single feature in the interpretation of HRS image. In this paper, we introduce a multi-task joint sparse and low-rank representation model to combine the strength of multiple features for HRS image interpretation. Specifically, a multi-task learning formulation is applied to simultaneously consider sparse and low-rank structure across multiple tasks. The proposed model is optimized as a non-smooth convex optimization problem using an accelerated proximal gradient method. Experiments on two public scene classification datasets demonstrate that the proposed method achieves remarkable performance and improves upon the state-of-art methods in respective applications.

Predicting electricity prices is a very important issue in modern society, because the associated decision process under uncertainty requires accurate forecasts for the economic agents involved. In this paper, we apply the decision tree extension of Random Forests to the prediction of electricity prices in Spain, but with the novelty of modeling prices jointly with demand, with the purpose of achieving greater accuracy than with univariate response Random Forests, particularly in price prediction, as well as understanding the effect of the input variables (lagged values of price and demand, current production levels of available energy sources) on the joint of the two outputs. The results are very encouraging, providing significant increase in price prediction accuracy. Also, interesting methodological challenges appear as far as the appropriate choice of the relative weights of price and demand in the joint modeling is concerned and a new procedure to provide the importance variable ranking is proposed. The partykit (package of R software) library allowing for multivariate Random Forests has been used.

Urban areas are centres of business and innovation. Freight transport is indispensable for the proper functioning of any modern urban society. Urban areas can’t function without an appropriate freight transport system, due to the need to replenish stocks of food and other goods in retail shops. The complexity of the decisions concerning implementation of measures to improve the movement of goods in the city requires tools designed to support this process. The purpose of this article is to introduce the possibility of applying the Analytic Hierarchy Process (AHP) as well as the Decision Making Trial and Evaluation Laboratory Method (DEMATEL) in choosing a set of measures and in analysing in the field of distribution logistics, which will help to solve the delivery problems and streamline the cargo flows in Szczecin, in the context of sustainable development.

Cut-off Low (COL) pressure systems significantly influence local weather in regions with high COL frequency, such as western North America. However, future changes in COL frequency, intensity, and precipitation patterns remain uncertain. This study examines projected COL changes and their drivers in western North America under a high-emission scenario (SSP585) using a multi-model ensemble from CMIP6 and a feature tracking algorithm. We compare historical simulations (1980-2009) and future projections (2070-2099), revealing a marked increase in COL track density during summer in the northeast Pacific and western United States, while a strong decrease is projected for winter, associated with shifts in jet streams. Climate models project an increase in COL-related precipitation in future climate, with winter and spring experiencing more intense and localized precipitation, while autumn showing a more widespread precipitation pattern. Additionally, there is an increased frequency of extreme precipitation events, though accompanied by large uncertainties. The projected increase in extreme precipitation highlights the need to understand COL dynamics for effective climate adaptation in affected areas. Further research should aim to refine projections and reduce uncertainties, supporting better-informed policy and decision-making.

This paper presents a Poisson multi-Bernoulli mixture (PMBM) forward-backward smoother for multiple extended target detection and tracking in the random finite sets (RFS) framework. The proposed method consists of forward filtering, achieved by the PMBM filter recursion, followed by backward smoothing, achieved by a parametric updated posterior PMBM density. The performance of the proposed method is evaluated in a simulation study.

(1) Background: Human papillomaviruses (HPV) are primarily related to cervical cancer around the world. This study presented an in silico design of a chimeric L1/L2 mRNA-based vaccine candidate against a diverse spectrum of human papillomaviruses; (2) Methods: We employed a computational strategy to predict and screen for antigenicity, allergenicity, toxicity, and conservation of immunodominant cytotoxic T cells, helper T cells, and linear B-cell epitopes from the most conserved HPV L1 and L2 proteins. The selected epitope peptides were coupled together with appropriate linkers to create a multi-epitope chimeric peptides. The mRNA-based vaccine was developed by combining an optimized open reading frame with co-translation regulation and co-transcription components; (3) Results: Twenty five (25) non-toxic, non-allergenic, highly antigenic, and conserved epitopes were identified. The final vaccine had a molecular weight of 60161.29 kDa, a theoretical pI of 9.44, and a solubility of 0.451. The mRNA-based vaccine had a stable mRNA structure with a minimum free energy of -731.10 kcal/mol and an estimated molecular weight of 644.98 kDa. The suggested vaccine had no cross-affinity for the human genome and achieved a global population coverage rate of 86.24%. The vaccine demonstrated a stable docking complex and robust interactions with Toll-like receptor 4 (TLR4) with binding affinities of -1377.5 kcal/mol and was capable of stimulating immunoglobulin IgG, IgM, T and B cells lymphocytes, and cytokines by in silico simulation; (4) Conclusion: The vaccine is considered a preventive and therapeutic candidate; however, further in vitro and in vivo tests are needed to prove its safety and efficacy.

Controlling an object that is extremely prone to oscillations is a complex and highly relevant task. The tendency to oscillate arises due to the presence of an oscillatory element and a delay element, and control is often complicated by the presence of an integrator in the object. For such objects, a very effective method of numerical optimization of the controller is not effective enough without choosing the most efficient structure, more efficient than the PID controller and even than the PIDD controller. The method of using the Smith predictor, which is switched on parallel to the plant, allows solving a similar problem, but the resulting quality of control remains not good enough, since a large overshoot remains in the system. The article recommends, after using the Smith predictor, to additionally use an external control loop, the sequential controller of which should also be designed using the numerical optimization method. But the Smith predictor is not the best solution either. The article recommends the use of pseudo-local feedback. Such a connection provides more opportunities, since its structure and parameters can be optimized, while the Smith predictor in its parameters is completely determined by the object model and its modification is not allowed. The article shows that even the best sequential controller in the case of using the Smith predictor on a test example still cannot provide the required quality of control; in such a system, significant overshoot remains, more than 10%. The proposed method allows reducing overshoot to less than 0.5%. It is shown that the resulting system is robust, since the quality of control remains within specified limits even when the gain changes by 30% in both directions.

Approximate Computing (AxC) has emerged as a promising paradigm to enhance performance and energy efficiency by allowing a controlled trade-off between accuracy and resource consumption. It is extensively adopted across various abstraction levels, from software to architecture and circuit levels, employing diverse methodologies. The primary objective of AxC is to reduce energy consumption for executing error-resilient applications, accepting controlled and inherently acceptable output quality degradation. However, harnessing AxC poses several challenges, including identifying segments within a design amenable to approximation and selecting suitable AxC techniques to fulfill accuracy and performance criteria. This survey provides a comprehensive review of recent methodologies proposed for performing Design Space Exploration (DSE) to find the most suitable AxC techniques, focusing on both hardware and software implementations. DSE is a crucial design process where system designs are modeled, evaluated, and optimized for various extra-functional system behaviors such as performance, power consumption, energy efficiency, and accuracy. A systematic literature review was conducted to identify papers that ascribe their DSE algorithms, excluding those relying on exhaustive search methods. This survey aims to detail the state-of-the-art DSE methodologies that efficiently select AxC techniques, offering insights into their applicability across different hardware platforms and use-case domains. For this purpose, papers were categorized based on the type of search algorithm used, with Machine Learning (ML) and Evolutionary Algorithms (EAs) being the predominant approaches. Further categorization is based on the target hardware, including Field-Programmable Gate Arrays (FPGAs), Application-Specific Integrated Circuits (ASICs), general-purpose Central Processing Units (CPUs), and Graphics Processing Units (GPUs). A notable observation was that most studies targeted image processing applications due to their tolerance for accuracy loss. By providing an overview of techniques and methods outlined in existing literature pertaining to the DSE of AxC designs, this survey elucidates the current trends and challenges in optimizing approximate designs.

Scaling the operation is the single greatest challenge in every enterprise. The more complex the enterprise, the greater the challenge. Scaling in healthcare has been a consistent challenge, with the need to meet clinical endpoints with less staff, increased costs of resources, regulatory oversight, and the goal of improving access to care. The article explores the emerging paradigm of multi-agent AI systems in healthcare, representing a significant leap beyond traditional Large Language Models. We comprehensively analyze the potential of these systems to revolutionize patient care, streamline administrative processes, and support complex clinical decision-making. The paper describes a hypothetical sepsis management system comprising seven specialized AI agents, each handling specific aspects of patient care, from data collection and diagnosis to treatment recommendations and resource management. We also examine applications in chronic disease management and hospital patient flow optimization. The technical implementation of these systems is discussed, including the use of advanced Large Language Models, inter-agent quality control measures, implementing guardrails, self-reflection, integration with Electronic Health Records, and the importance of explainable AI for decision transparency. In addition to describing the promising potential benefits, such as enhanced diagnostic accuracy and personalized treatment plans, we address significant challenges, including data quality assurance, workflow integration, and ethical considerations. We conclude the article by highlighting future directions, such as integrating IoT devices and developing more sophisticated natural language interfaces. Our work underscores the transformative potential of multi-agent AI systems in healthcare while emphasizing the need for rigorous validation, ethical oversight, and a patient-centered approach in their development and implementation.

In the dynamic landscape of online shopping, predicting user behaviors such as clicks, cart additions, and orders is crucial for optimizing sales strategies. Traditional recommendation systems often focus on a single objective, limiting their effectiveness in a multifaceted e-commerce environment. This article proposes a multi-objective recommendation system that leverages previous events in user sessions to forecast these key metrics, addressing challenges such as imbalanced positive and negative samples, varying session lengths, and the need for effective sampling techniques. Our approach integrates LightGBM, XgBoost, and Recbole GRU4Rec through ensemble learning, combining the strengths of these models to enhance prediction performance. Extensive evaluations demonstrate that our model outperforms existing methods, offering significant improvements in accuracy and robustness. This work provides a comprehensive solution for online retailers to better predict user behaviors and optimize their sales strategies, ultimately enhancing customer satisfaction and business outcomes.

The rapid increase in unstructured data across various fields has made multi-document comprehension and summarization a critical task. Traditional approaches often fail to capture relevant context, maintain logical consistency, and extract essential information from lengthy documents. This paper explores the use of Long-context Large Language Models (LLMs) for multi-document summarization, demonstrating their exceptional capacity to grasp extensive connections, provide cohesive summaries, and adapt to various industry domains and integration with enterprise applications/systems. The paper discusses the workflow of multi-document summarization for effectively deploying long-context LLMs, supported by case studies in legal applications, enterprise functions such as HR, finance, and sourcing, as well as in the medical and news domains. These case studies show notable enhancements in both efficiency and accuracy. Technical obstacles, such as dataset diversity, model scalability, and ethical considerations like bias mitigation and factual accuracy, are carefully analyzed. Prospective research avenues are suggested to augment the functionalities and applications of long-context LLMs, establishing them as pivotal tools for transforming information processing across diverse sectors and enterprise applications.

Large language models (LLMs) are essential to the field of natural language processing, and as their applications expand, security risks have become increasingly prominent. This paper introduces a novel benchmark for evaluating LLMs security, termed CS-Eval, designed to effectively assess the models' ability to address vulnerabilities. CS-Eval targets seven key security risks: ethical dilemmas, marginal topics, error detection, detailed event handling, cognitive bias, logical reasoning, and privacy identification, and establishes a Multi-Security Hazard Dataset (MSHD). The evaluated models include GPT-4o, Llama-3-70B, Claude-3-Opus, ERNIE-4.0, Abab-6.5, Qwen1.5-110B, Gemini-1.5-Pro, Doubao-Pro, SenseChat-V5, and GLM-4. We analyzed each model's performance in relation to these security risks and provided recommendations for improvement. Experimental results demonstrate varying levels of effectiveness across models, with GPT-4o exhibiting the best overall performance. Moreover, the relationship between security enhancement and model capa-bility is nonlinear, indicating that improving safety requires a multifaceted approach, considering various factors in both development and application.

Under the wave of technological advancement and industrial upgrading, new productivity is deeply influencing the field of vocational education and promoting fundamental changes in teachers' roles. Modern teachers must not only keep pace with technological development but also master innovative teaching modes and guide students to form correct values. They are gradually evolving from mere knowledge transmitters to guides for learning, stimulators of interest, explorers of in-depth research, and promoters of comprehensive growth. Through interdisciplinary knowledge structures and innovative abilities, combined with advanced tools such as information technology and artificial intelligence, teachers innovate teaching methods to meet students' diverse learning needs and focus on cultivating students' professional skills, comprehensive qualities, and innovative spirits. This multi-dimensional reshaping of roles is not only an inevitable choice for the development of vocational education but also provides important insights for educational reform.

Antiviral peptides (AVPs) represent a promising strategy for addressing the global challenge of viral infections and their growing resistance to traditional drugs. Lab-based AVP discovery methods are resource-intensive, highlighting the need for efficient computational alternatives. In this study, we developed five non-trained but supervised Multi-Query Similarity Search Models (MQSSMs) integrated into the StarPep toolbox. Rigorous testing and validation across diverse AVP datasets confirmed the models' robustness and reliability. The top-performing model, M13+, demonstrated impressive results with an accuracy of 0.969 and a Matthew’s correlation coeffi-cient of 0.71. To assess their competitiveness, the top five models were benchmarked against 14 publicly available machine learning and deep learning AVP predictors. The MQSSMs outper-formed these predictors, highlighting their efficiency in terms of resource demand and public ac-cessibility. Another significant achievement of this study is the creation of the most comprehensive dataset of antiviral sequences to date.

The Zero Trust Architecture (ZTA) security system follows the "never trust, always verify" principle. The process constantly verifies users and devices trying to access resources. This paper describes how Microsoft Azure uses ZTA to enforce strict identity verification and access rules across the cloud environment to improve security. Implementation is time-consuming and difficult. Azure's extensive services and customizations require careful design and implementation. Azure administrators struggle to navigate and change configurations due to its complex user interface (UI). Each Azure ecosystem component must meet ZTA criteria. ZTA's comprehensive policy definitions, multi-factor and pass-wordless authentication, and other advanced features are tested in a mid-size business scenario. These configuration changes require a solid grasp of Azure's architecture and Zero Trust. Implementing an Azure ZTA reduces vulnerabilities and restricts authorized users' access to critical resources. Implementation is time-consuming and expensive, requires a significant commitment to changing IT procedures, and can be confusing because the same features are available in multiple places. Azure ZTA has shown great potential for both hybrid and cloud-native companies.

While advances in information and communication technology have increased the efficiency of information distribution, it has also brought several challenges to the database industry. One of the main challenges is ensuring the real-time availability of data, which is critical. In addition, downtime in centralized database systems can cause significant failures. Therefore this research applies database replication, especially the multi-master method, is used to increase availability and reduce the possibility of failure. For distributed transaction distribution, this research uses the auto-promote master method and web services for PostgreSQL database replication. The focus of the research is on real-world college site selection transactions, where speed, scalability, and high data availability are critical. The results show that combining these methods can improve system performance and protect data availability. With fast response time, high throughput, and low error rate, the API performs well with various loads. As a testament to scalability and reliability, the system can handle large volumes of traffic without experiencing significant crashes. For containerization, Docker supports efficient and stable performance and ensures consistency and manageability. Future recommendations include improving the data security mechanism and further efforts to optimize the distribution system architecture.

The presence of cracks reduces egg quality and safety, which are easy to cause food safety hazards to consumers. Machine vision-based methods for crack egg detection have made significant success on in-domain egg data. However, the performance of deep learning models usually decreases under practical industrial scenarios, such as the different egg varieties, origins, and environmental changes. Existing researches which rely on improving network structures or increasing training data volumes, can not effectively solve the problem of model performance decline on unknown egg testing data in practical egg production. To address these challenges, a novel and robust detection method is proposed to extract max domain-invariant features to enhance the model performance on unknown testing egg data. Firstly, multi-domain egg data is built on different egg origins and acquisition devices. Then, a multi-domain trained strategy is established by using Maximum Mean Discrepancy with Normalized Squared Feature Estimation (NSFE-MMD) to obtain the optimal matching egg training domain. With the NSFE-MMD method, the original deep learning model can be applied without network structure improvements, which reduces the extremely complex tuning process and hyperparameter adjustments. Finally, robust crack egg detection experiments are carried out on several unknown testing egg domains. The YOLOV5 model trained by proposed multi-domain trained method with NSFE-MMD has a detection mAP of 86.6\% on the unknown test domain 4, and the YOLOV8 model has a detection mAP of 88.8\% on domain 4, which is an increase of 8\% and 4.4\% compared to the best performance of models trained on a single domain, and an increase of 4.7\% and 3.7\% compared to models trained on all domains. In addition, the YOLOV5 model trained by the proposed multi-domain trained method has a detection mAP of 87.9\% on egg data of the unknown testing domain 5. The experimental results demonstrate the robustness and effectiveness of the proposed multi-domain trained method, which can be more suitable for the large quantity and variety of egg detection production.

Previous research has proven that one of the fundamental requirements for ensuring increased profitability and economic competitiveness of offshore-based projects is co-locating different technologies within the same marine space. This paper presents a number of techno-feasibility analyses for floating offshore technologies for the Maltese Islands, located in the Central Mediterranean Sea. The first part compares the feasibility of offshore-based solar photovoltaic prices with those onshore, taking into consideration Malta’s land prices. The second part considers the use of a novel floating breakwater design that integrates energy storage. The breakwater is used to create a sheltered water area in deep waters for a multi-use marine park. Different revenue streams for the floating break water are considered, including renting the sheltered marine space out to operators of floating solar farms, aquaculture cages and vessel berthing facilities, and the provision of energy storage services. It is found that the combined income from the multiple revenue streams is still insufficient to justify the investment and that financially support from Government is essential to render the floating breakwaters viable.

Maternal obesity and over/undernutrition can have a long-lasting impact on offspring health during critical periods in the first 1000 days of life. Children born to mothers with obesity have reduced immune responses to stimuli which increase susceptibility to infections. Recently, maternal western-style diets (WSD), high in fat and simple sugars, have been associated with skewing neonatal immune cell development, and recent evidence suggests that dysregulation of innate immunity in early life has long-term consequences on metabolic diseases and behavioral disorders in later life. Several factors contribute to abnormal innate immune tolerance or trained immunity, including changes in gut microbiota, metabolites, and epigenetic modifications. Critical knowledge gaps remain regarding the mechanisms whereby these factors impact fetal and postnatal immune cell development, especially in precursor stem cells in bone marrow and fetal liver. Components of the maternal microbiota that are transferred from mothers consuming a WSD to their offspring are understudied and identifying cause and effect on neonatal innate and adaptive immune development needs to be refined. Tools including single-cell RNA-sequencing, epigenetic analysis, and spatial location of specific immune cells in liver and bone marrow are critical for understanding immune system programming. Considering the vital role of immune function plays in offspring health, it will be important to understand how maternal diets can control developmental programming of innate and adaptive immunity.

Pharmacists must acquire the necessary knowledge to provide better drug therapy to patients. In other words, educational programs need to facilitate behavioral changes among pharmacists. Therefore, this study aimed to evaluate how the behavior of pharmacists changed after attending a palliative care educational program. We conducted a web-based questionnaire survey examining the behavior of pharmacists regarding palliative care before participating in the program, two months after participating in the program, and eight months after participating in the program, to determine the behavior and changes over time. For all questions, scores were higher at two and eight months after attending the program than before attending the program (P &lt;0.05). In addition, no significant difference was observed between two and eight months after attending the program for all questions (P =0.504-1.000). The knowledge gained from the educational program was used to repeatedly intervene with patients with cancer, to address the various symptoms they experienced and maintain their behavior. The proven effectiveness of this program serves as a stepping stone for a nationwide rollout across Japan’s 47 prefectures.