The present study aimed to investigate the effect of cold deformation on the precipitation kinetics of a binary CuSc alloy containing 0.4 wt.% scandium using the experimental analysis method of differential scanning calorimetry (DSC). Non-deformed and 75% cross-section reduced cold-rolled, supersaturated specimens were tested at non-isothermal DSC runs at up to five different heating rates. The DSC results showed that cold deformation significantly accelerated the precipitation process in the binary alloy, leading to a decrease in the initial and peak temperatures of the exothermic reactions. The activation energies calculated with the Kissinger method, indicated that the precipitation activation energy decreased with increasing cold deformation. The findings of this study provide worthy implications to further optimize the processing of Cu-Sc alloys with improved mechanical properties.

The vulnerability of vegetation in the Middle East to meteorological conditions and climate change, especially those leading to drought, is high. Despite the importance of the Amu Darya and Kabul River Basins (ADB and KRB) as a region in which more than 15 million people live, and its vulnerability to global warming, only several studies addressed the issue of the linkage of meteorological parameters on vegetation for the eastern basins of Afghanistan. In this study, data from the Moderate Resolution Imaging Spectroradiometer (MODIS), Global Precipitation Measurement Mission (GPM), and Land Data Assimilation System (GLDAS) to examine the impact of meteorological parameters on vegetation for the eastern basins of Afghanistan for the period from 2000 to 2021. The study utilized several indices, such as Precipitation Condition Index (PCI), Temperature Condition Index (TCI), Soil Moisture Condition Index (SMCI), and Microwave Integrated Drought Index (MIDI). The relationships between meteorological quantities, drought conditions, and vegetation variations were examined by analyzing the anomalies and using regression methods. The results showed that the years 2000, 2001, and 2008 had the lowest vegetation coverage (VC) (56, 56, and 55% of the study area, respectively). On the other hand, the years 2010, 2013, 2016, and 2020 had the highest VC (71, 71, 72, and 72% of the study area, respectively). The trend of the VC for the eastern basins of Afghanistan for the period from 2000 to 2021 was upward. High correlations between VC and soil moisture (R = 0.70, p = 0.0004), and precipitation (R = 0.5, p = 0.008) were found, whereas no significant correlation was found between VC and drought index MIDI. It was revealed that soil moisture, precipitation, land surface temperature, and area under meteorological drought conditions explained 45% of annual VC variability.

Phoretic mites use bark beetles for transportation to new, suitable habitats. Some phoretic mites act as predators and parasitoids of the bark beetles’ immature stages, especially egg and early larval stages, and are potential agents for the biological control of scolytine forest pests. One of the most numerous and largest mite orders is Mesostigmata which live very frequently in relationships with other invertebrates. Many are found in association with various species of bark beetles. Here, a total of 41 specimens of different bark beetles of the genus Ips (I. acuminatus, I. sexdentatus and I. typographus) were studied for presence, species composition, and abundance of phoretic mites. The beetles were collected on dead wood and parts of tree bark of Pinus nigra, P. slyvestris and Picea abies in the Black Sea Mountains in Kastamonu and Artin Province of Turkey. A total of 9 mite species in 2 genera were found, including Dendrolaelaps quadrisetus, Ereynetes sp., Histiostoma piceae, Paraleius cf. leontonychus, Pleuronectocaeleno barbara., Proctolaelaps hystricoides, Schizostethus simulatrix, Trichouropoda lamellosa and Urobovella ipidis. All species and genera are identified for the first time within Turkish fauna.

The article discusses the results of investigations performed during a thermo-mechanical treatment of forgings made of chromium-molybdenum 42CrMo4 grade steel. The treatment was realized during a regular series production. The forging process was combined with a heat treatment carried out directly after forging on a specially adapted station. Such a production technology will make it possible to eliminate the step of repeated heating of the forgings. On the example of an element of a steering gear, it was demonstrated how it is possible to perform an isothermal annealing process starting from the temperature at which the trimming of the forgings ends. During the cooling of the forgings, it is enough to maintain the temperature at the proper level in order for the exothermal phase transformation of austenite into pearlite to take place. With an appropriate design of the processing line, the heat released during the transformation could be used to maintain the applied temperature, thus limiting the consumption of energy needed to power the devices. The test results show that, with the properly selected temperature of isothermal annealing, it is possible to obtain an equilibrial ferritic-pearlitic structure in the required hardness scope. Introducing such a solution into the industrial practice would allow significant savings of the energy used for the heat treatment.

The fluvial-lagoon-deltaic system of the Palizada river in Campeche is an ecosystem of socioeconomic and ecological importance. It is justifiable to carry out studies in this system, due to its connection with another larger ecosystem called Términos lagoon. The objective of this investigation was to analyze the concentration of Pb and Cd in sediments of the fluvial-lagoon-deltaic system of the Palizada river and to determine, with this, the contamination index of these metals. Cd presented the highest concentration in sampling sites and climatic seasons with respect to Pb, with a maximum value of 53.926 ± 5.045, while Pb was 10.421 ± 0.218 μg g-1. The same tendency was presented with pollution and geoaccumulation indexes, where the Cd index stands out. The enrichment of heavy metals was identified through the accumulation of Cd and Pb, such process was evaluated through the geoacumulation index (Igeo). The results of this indicated that these elements are contaminating with an anthropogenic origin mainly. This element represents a toxic risk for the Palizada system, due to its high toxicity even at low concentrations, as well as to evaluate the sublethal effects in organisms that inhabit this system and it requires the implementation of an integral monitoring.

Medical imaging is an active field of research that fosters the necessity for novel multimodal imaging probes. In this line, nanoparticle-based contrast agents are of special interest, since those can host functional entities either within their interior, reducing potential toxic effects of the imaging tracers, and on their surface, providing high payloads of probes, due to their large surface-to-volume ratio. The long-term stability of the particles in solution is an aspect usually under-tackled during probe design in research laboratories, since their performance is generally tested briefly after synthesis. This may jeopardize a later translation into practical medical devices, due to stability reasons. To dig into the effects of nanoparticle aging in solution, respect to their behavior in vivo, iron oxide stealth nanoparticles were used at two stages (3 weeks vs. 9 months in solution), analyzing their biodistribution in mice. Both sets of nanoprobes showed similar sizes, zeta potentials and morphology, as observed by DLS and TEM but, fresh nanoparticles accumulated in the kidneys after systemic administration, while aged ones accumulated in liver and spleen, confirming an enormous effect of particle aging on their in vivo behavior, despite barely noticeable changes perceived on a simple inspection of their structural integrity.

Previous research suggests that the economic crisis can affect mental health. The purpose of this study was to analyse the association of risk of poor mental health with various socioeconomic, demographic, health, quality of life and social support variables; and to evaluate the contribution of socioeconomic variables most affected by the beginning of the economic crisis (employment situation and income) on the changes in the prevalence of the risk of poor mental health between 2005 and 2010. A study of prevalence evolution in adult population residents of the Valencian Community in the Spanish Mediterranean was conducted. We studied 5781 subjects in 2005 and 3479 in 2010. Logistic regression models have been adjusted to analyse the association between variables. A standardization procedure was carried out to evaluate which part of the changes in overall prevalence could be attributed to variations in the population structure by age, sex, employment status and income between the years under study. The prevalence of GHQ + increased from 2005 to 2010, in both men and women. Several variables were closely associated with the risk of poor mental health (sex, age, country of birth, number of non-mental chronic diseases, social support, disability, cohabitation in couple, employment status, and income). The changes produced as a result of the onset of the economic crisis in income and unemployment (increase in low income and in unemployment rates) contributed to the increase of poor mental health risk. This could confirm the sensitivity of mental health to the economic deterioration caused by the crisis.

Using a breast cancer (BC) cellular model: MDA-MB-231 cells with blocked synthesis of galacto-sylceramide (GalCer; MDA.Δ.UGT8.4) and MCF7 and T47D cells that over-produced GalCer (MCF7.UGT8 and T47D.UGT8), we found that GalCer increased resistance to doxorubicin, paclitaxel, and cisplatin serving as an anti-apoptotic molecule. These results were supported by a study using murine mammary carcinoma 4T1 cells over-producing GalCer, which were trans-planted into Balb/c mice and were more resistant to doxorubicin therapy than the control. Sub-sequent studies revealed that GalCer specifically downregulated the level of pro-apoptotic TNFRSF1B and TNFRSF9 genes and increased the level of the anti-apoptotic BCL2 gene expres-sion, suggesting that GalCer regulates their expression at the level of transcription. Consistent with this hypothesis, MDA-MB-231 and MCF7.UGT8 cells with high GalCer content showed lower activity of TNFRSF1B and TNFRSF9 promoters than cells lacking GalCer. In contrast, the activity of the BCL2 promoter in MCF7.UGT8 was higher than in MCF7 cells without GalCer. However, no difference in BCL2 promoter activity was observed between MDA-MB-231 cells with high GalCer level and GalCer-negative MDA.Δ.UGT8.4 cells. Instead, we found that GalCer increased the stability of Bcl-2 mRNA. As a candidate protein that simultaneously increases the expression of TNFRSF1B and TNFRSF9 genes and decreases the expression of BCL2 gene and stability of Bcl-2 transcripts is probably p53, its expression was analysed in BC cells containing various amounts of GalCer. In agreement with this hypothesis, BC cells with high GalCer con-tent are characterized by significantly lower expression of p53, and inhibition of p53 using siR-NA resulted in decreased expression of TNFRS1B and TNFRS9 genes and increased expression of BCL2 gene.

The world is currently experiencing the fourth industrial revolution driven by the newest wave of digitisation in the manufacturing sector. The term Industry 4.0 (I4.0) represents at the same time: a paradigm shift in industrial production, a generic designation for sets of strategic initiatives to boost national industries, a technical term to relate to new emerging business assets, processes and services, and a brand to mark a very particular historical and social period. I4.0 is also referred to as Industrie 4.0 the New Industrial France, the Industrial Internet, the Fourth Industrial Revolution and the digital economy. These terms are used interchangeably in this text. The aim of this article is to discuss major developments in this space in relation to the integration of new developments of IoT and cyber physical systems in the digital economy, to better understand cyber risks and economic value and risk impact. The objective of the paper is to map the current evolution and its associated cyber risks for the digital economy sector and to discuss the future developments in the Industrial Internet of Things and Industry 4.0.

In the second half of the 19th century new methods for quarrying and processing natural stone are developed. In the Nordic countries Sweden, Norway and Finland this technological pro­gress goes hand in hand with a systematic geological mapping and large-scale exploitation of natural stone deposits. As a result, new constructions are developed—changing the building practice in these countries. With the end of historicism a new architecture arises that particularly in Norway and Finland acquires a national-romantic character. This paper examines the interaction between geological exploration, commercial development, technical inventions and the development of a national-romantic architecture.

In the article, the authors presented the problem of the transition effect in bridge engineering, its causes, negative consequences, and suggested a solution involving the use of integral bridges with the embankment through a spatial bars structure using reinforced composite polymer material. Integral bridges are designed to collaborate with road or railway embankments in bearing loads. Additionally, their application minimizes maintenance and construction costs while enhancing durability. Current solutions in bridge engineering were described. It is predicted that the presented concept will reduce the amount of plastic waste and contribute to the long-term use of materials. The article emphasized the importance of sustainable development, recycling, and the potential application of substitute materials.

The presence of heavy metals in industrial effluents has recently become a source of concern for human health and the environment. Efficient removal of metal ions and wastewater treatment is essential for protecting public health and the environment. In this study, we present an eco-friendly, green synthesis of reactive and fully dispersed zerovalent iron nanoparticles (nZVI) in carbon nanofibers via an electrospinning technique. In this novel study, green tea (GT) was used as environmentally friendly, polyvinyl alcohol (PVA) was used for the stabilization and reduction of nZVI, and tetraethyl orthosilicate (TEOS) was added to provide flexibility and to increase the specific surface area of the nZVI based nanofibers. GT contains polyphenols, which act as reducing agents, converting iron ions into nZVI and the particles can then serve as the building blocks for the carbon nanofibers. TEOS can also contribute to the stability of the nZVI by coating their surfaces with a silica layer. This silica layer helps prevent the oxidation of the nZVI, thereby reducing their catalytic activity. The nZVI-based composite (∼ 400 nm) / carbonized (∼ 200 nm) nanofibrous mats were fully characterized by scanning electron microscopy. The average size of the nZVI embedded in the composite and carbonized nanofibers can range from 50 nm to 100 nm. The x-ray diffraction (XRD) analysis of nZVI-based carbon nanofibers showed that there is no crystallinity and a single-phase cubic structure. Both energy-dispersive X-ray spectroscopy (EDX) and Fourier transform infrared (FTIR) analysis also confirmed the formation of single-phase nZVI-based composite / carbonized nanofibers. The high intensity of the peaks in the FTIR spectrum indicates the formation of nZVI in the nanofibers structure. The electrospun nZVI-based carbon nanofibers have a higher surface area and better reactivity due to small particle size and large surface area-to-volume ratio. They can provide excellent water stability and dispersibility in water compared to bulk nZVI, which tend to agglomerate and settle quickly. Additionally, nanofiber morphology can enhance the mechanical strength and durability of the composite material. Due to low-cost synthesis and their high efficiency in removing pollutants, these nanofibers could be used as nano-filters for wastewater treatment.

Plastics, primarily microplastics, are among the greatest pollutants in aquatic environments. Their removal and/or degradation in these environments are crucial to ensure an optimal future of the ecosystems. In this work MnO2 particles were synthesized and characterized for the removal polystyrene microplastics as a model. MnO2 catalyzes the peroxide reaction, resulting in the formation of oxygen bubbles that propel the pollutants to the surface, achieving removal efficiencies of up to 80%. To achieve this, hydrothermal synthesis was employed using various methods. Parameters such as MnO2, microplastics and H2O2 concentrations were varied to determine the optimal conditions for microplastics recovering. The ideal conditions for a low microplastic concentrations of microplastics (10 g L-1) are 0.2 g L-1 MnO2, 1.6% of H2O2 and 0.01 triton as a surfactant. In these conditions the micromotors can recover approximately of 80% 300 nm sized polystyrene microplastic within 40 min.

Bunyaviruses represent the largest group of RNA viruses, and are the causative agent of a variety of febrile and hemorrhagic illnesses. Originally characterized as a single serotype in Africa, the number of described bunyaviruses now exceeds over 500, with its presence detected around the world. These predominantly tri-segmented, single-stranded RNA viruses are transmitted primarily through arthropod and rodent vectors, and can infect a wide variety of animal and plants. Although encoding for a small number of proteins, these viruses can inflict potentially fatal disease outcomes, and have even developed strategies to suppress the innate antiviral immune mechanisms of the infected host. This short review will attempt to provide an overall description of the order Bunyavirales, describing the mechanisms behind their infection, replication and their evasion of the host immune response. Furthermore, the historical context of these virus will be presented, starting from their original discovery almost 80 years ago, to the most recent research pertaining to viral replication and host immune response.

A generalization of the sum of divisors function involves a recursive definition. This leads to variants of superabundant numbers, colossally abundant numbers, and Gronwall's theorem (relevant to the Riemann hypothesis).

The adoption of health information technology (HIT) has increased considerably, contributing to better communication between physicians and patients and providing technological bases for learning and institutional improvement. This type of technology brings many challenges; therefore, understanding its adoption and assimilation is important to assess its potential for engendering desirable outcomes in health management. The assimilation of health information systems should be highlighted as their importance in health organisations is now recognised as a key facilitator assisting in providing better health outcomes. Thus, this study aimed to analyse HIT adoption based on models such as Technology, Organisation and Environment (TOE), which analyses at the organisational level, with other models, such as the Technology Acceptance Model (TAM), which analyses at the individual level, and the assimilation of the adopted technologies.

Frames are more stable as compared to bases under the action of a bounded linear operator. Sums of different frames under the action of a bounded linear operator are studied with the help of analysis, synthesis and frame operators. A simple construction of frames from the existing ones under the action of such an operator is presented here. It is shown that a frame can be added to its alternate dual frames, yielding a new frame. It is also shown that the sum of a pair of orthogonal frames is a frame. This provides an easy construction of a frame where the frame bounds can be computed easily. Moreover, for a pair of orthogonal frames, the necessary and sufficient condition is presented for their alternate dual frames to be orthogonal. This allows for an easy construction of a large number of new frames.

Many reported sea level records are often not a single measurement. They are then a composition of different records from several tide gauges. Sometimes, they are from the same tide gauge, but the tide gauge stability has been affected by earthquakes. This is the case of Guam as discussed in the present manuscript. The claimed sea level acceleration of Guam is only the result of two earthquakes that have compromised the stability of the tide gauge.

Eutherians have 11 retrotransposon Gag-like (RTL)/sushi-ichi retrotransposon homolog (SIRH) genes presumably derived from a certain retrovirus. Accumulating evidence indicates that the RTL/SIRH genes play a variety of roles in the current mammalian developmental system, such as in the placenta, brain and innate immune system in a eutherian-specific manner. It has been shown that the functional role of Paternally Expressed 10 (PEG10) in placental formation is unique to the therian mammals, as are the eutherian-specific roles of PEG10 and PEG11/RTL1 in maintaining the fetal capillary network and the endocrine regulation of RTL7/SIRH7 (aka Leucine Zipper Down-Regulated in Cancer 1 (LDOCK1)) in the placenta. In the brain, PEG11/RTL1 is expressed in the corticospinal tract and hippocampal commissure, mammalian-specific structures, and in the corpus callosum, a eutherian-specific structure. Unexpectedly, at least three RTL/SIRH genes, RTL5/SIRH8, RTL6/SIRH3 and RTL9/SIRH10, play important roles in combating a variety of pathogens, viruses, bacteria and fungi, respectively, suggesting that the innate immunity system of the brain in eutherians has been enhanced by the emergence of these new components. In this review, we will summarize the function of 10 out of the 11 RTL/SIRH genes and discuss their roles in eutherian development and evolution.

The current plant two-sex model makes the assumption that there are only two sexual reproductive states: male and female. However, the application of this model to the plant alternation of generations requires the subtle redefinition of several common terms related to sexual reproduction, which also seems to obscure aspects of one or the other plant generation: For instance, the homosporous sporophytic plant is treated as being “asexual,” and the gametophytes of angiosperms treated like mere gametes. In contrast, the proposal is made that the sporophytes of homosporous plants are indeed sexual reproductive organisms, as are the gametophytes of heterosporous plants. This view requires the expansion of the number of sexual reproductive states we accept for plants, therefore a three-sex model for homosporous plants and a four-sex model for heterosporous plants are described and then contrasted with the current two-sex model. These new models allow the use of sexual reproductive terms in a manner largely similar to that seen in animals, and may better accommodate the plant alternation of generations life cycle than does the current plant two-sex model. These new three-sex and four-sex models may also help stimulate new lines of research, and examples of how they might alter our view of the flower, and may lead to new perspectives in terms of sexual determination, are presented. Thus it is suggested that plants have more than merely two sexual reproductive states, and that recognition of this may promote our study and understanding of plants.

Recently, several research groups have reported on anomalous enhancement of the self-field critical currents, Ic(sf,T), at low temperatures in superconductor/Dirac-cone material/superconductor (S/DCM/S) junctions. Some papers attributed the enhancement to the low-energy Andreev bound states arising from winding of the electronic wave function around DCM. In this paper, Ic(sf,T) in S/DCM/S junctions have been analyzed by two approaches: modified Ambegaokar-Baratoff and ballistic Titov-Beenakker models. It is shown that the ballistic model is an inadequate tool to analyze experimental data from S/DCM/S junctions. The primary mechanism for limiting superconducting current in S/DCM/S junctions is different from the conventional view that the latter is the maximum value within the order parameter phase variation. Thus, there is a need to develop a new model for self-field critical currents in S/DCM/S systems.

The electricity generated from fossil fuel and nuclear energy has negative impacts on the environment and has shown a need to search for and promote the use of clean, renewable and sustainable energy resources such as wind, solar and geothermal resources. Nowadays, wind energy resource has emerged as the fastest-growing source of energy on an overall scale. However, the selection of the best location for constructing a wind farm is a vital issue that can be considered a site selection problem, which involves various conflicting factors. Therefore, it is classified as a multi-criteria decision-making (MCDM) problem. In this research, the site selection of wind power plants is conducted in Burundi country. The Fuzzy Analytic Hierarchy Process (FAHP) was used to weigh the criteria considering their relative importance. The main factors affecting optimal wind farm location considered in this study are wind speed, slope, distance from the grid network, distance to roads, and land use/land cover (LULC). Furthermore, a geographic information system (GIS) is utilized to generate the final suitability wind farm locations map. The obtained results show that 20.91% of the total study area is suitable; nevertheless, only 1.96% is highly suitable for wind farm placement. The western part of Burundi is concluded to be the most suitable area for wind farm construction and the most area is situated in Lake Tanganyika.

Background and objectives: The inadequate knowledge of complementary and alternative medicine (CAM) among health professionals may put their clients in risky situation because they then would find information about CAM from unreliable sources. Clinical psychologists (CPs), as health professionals, have also the opportunity to provide psychoeducation on the latest CAM scientific research to their clients. The current study aimed to explore knowledge and educational needs of CAM among CPs in Indonesia because previous studies on exploring CAM knowledge and educational needs of CAM were primarily conducted in Western countries. Materials and Methods: Data were collected through semi-structured face-to-face interviews with 43 CPs in public health centers (PHCs) in Indonesia. Most interviews were held at the PHCs where participants worked and interviews lasted for 55 minutes, on average. The interview recordings were transcribed and were analyzed using deductive thematic analysis. Results: Five main themes emerged within participants’ responses regarding CAM knowledge and educational needs. First (CAM understanding), participants’ responses ranged from those with little or no prior knowledge of CAM treatments and uses, to those with much greater familiarity. Second (source of knowledge), participants’ access ranged widely in terms of references, from popular to scientific literature. Third (why is it important?), participants identified CAM essentially as part of Indonesian culture and it was therefore crucial to have this cultural knowledge. Fourth (the challenges and what is needed?), the challenges for improving participants’ knowledge came from personal and institutional levels. Fifth (what and how to learn?), participants advised that only CAM treatments that fit in brief psychotherapy sessions should be introduced in professional training. Conclusions: This qualitative study discovered that CAM was neither well-known nor understood widely. Participants advised that professional associations and health institutions should work together in enhancing knowledge of CAM and incorporating CAM education into psychology education.

Using structured light to drive colloidal motors, due to its advantages of remote manipulation, energy tunability, programmability, and controllability of spatiotemporal distribution, has been attracting much attention in the fields of targeted drug delivery, environmental control, chemical agent detection, and smart device design. Here, we focus on studying the group control of colloidal made from a photo-responsive organic polymer molecule NO-COP (N,O-Covalent organic polymer). These colloidal motors mainly respond to the light intensity patterns. We chose a digital micromirror device (DMD) to modulate the structured light field shining on the sample, by considering its merit of fast refreshing speed, good programmability, and high-power threshold. It is found that under ultraviolet or green light modulation, such colloidal motors exhibit various group behaviors including group diffusion, group patterning, and group migration. The qualitative interpretation is also provided for these observations.

Dye-based angiography is the main imaging modality in evaluating the vasculature of the eye. Although most commonly used to assess retinal vasculature, it can also delineate normal and abnormal blood vessels in the anterior segment diseases – but is limited due to its invasive, time-consuming methods. Thus, anterior segment optical coherence tomography angiography (AS-OCTA) is a useful non-invasive modality capable of producing high-resolution images to evaluate the cornea and ocular surface vasculature. AS-OCTA has demonstrated the potential to detect and delineate blood vessels in the anterior segment with quality images comparable to dye-based angiography. AS-OCTA has a diverse range of applications for the cornea and ocular surface, such as objective assessment of corneal neovascularization and response to various treatments; diagnosis and evaluation of ocular surface squamous neoplasia; and evaluation of ocular surface disease including limbal stem cell deficiency and ischemia. Our review aims to summarize the new developments and clinical applications of AS-OCTA for the cornea and ocular surface.

Leukemia is a form of blood cancer that results in an increase in the number of white blood cells in the body. The correct identification of Leukemia at any stage is essential. The current traditional approaches rely mainly on field expertise' knowledge, which is time consuming. The poor understanding and a long period of examination might damage the human body. In this situation an automated Leukemia identification delivers more reliable and accurate diagnostic information. To effectively diagnose acute lymphoblastic Leukemia from blood smears pictures, a new strategy based on traditional image analysis techniques with machine learning techniques, and a composite learning approach was constructed in this experiment. To identify the type of acute Leukemia first, four well-known machine learning models were utilized. It was discovered that Support Vector Machine (SVM) Provides the highest accuracy in this scenario. To boost the performance, a deep learning model Resnet50 was hybridized with SVM model. Finally, it was revealed that this composite approach achieved 99.9% accuracy.

This paper describes the design and implementation of an ultrasonic non-contact air-coupled technique (UNCACT) using antisymmetric Lamb waves (ALW) for NDT assessment in novel composite sandwich plates of the car body shell. This technique is complemented with a C-Scan image implementation using this kind of guided waves. The finite element method using Comsol 6.1 is developed for the interpretation of the several wave modes presented in the experiments, including the ALW mode. The phase velocity method (PVM) is applied for the verification of the ALW mode in the portion of the RF signal necessary in the C-Scan image.

New composite with core-shell structure based on magnesium hydride and finely dispersed aluminum powder with aluminum oxide shell was mechanically synthesized. We used magnesium chips to produce magnesium hydride and aluminum wire after exploitation to produce nano-sized aluminum powder. The beginning of the hydrogen release from composite occurred at the temperature of 117°C. The maximum desorption temperature from the MgH₂-EEWAl composite (10 wt.%) is 336°C compared to pure magnesium hydride – 417°C. The mass content of hydrogen in the composite is 5.5 wt.%. The positive effect of aluminum powder produced by the electric explosion of wires method on reducing the activation energy of desorption was demonstrated. Calculations showed that the activation energy of desorption for the composite is 106±1 kJ/mol, compared with pure magnesium hydride, whose activation energy was 155±2 kJ/mol. The results obtained make it possible to expand the possibility of using magnesium and aluminum waste for hydrogen energy.

The study proposes a theoretical method for evaluating the 'safety against derailment' indicator of a specialized train composition for the transportation of very long rails. A composition of nine wagons, suitable for the transportation of rails with a length of 120 m, is considered. For the remaining recommended rail lengths, the number of wagons is reduced or increased, the method being modified depending on the required configuration. In accordance with the requirements of EN 14363:2019, the composition is in a curve with a radius of R=150 m. The rails bend, some of them contact the vertical stanchions of the wagon and cause additional transverse forces, which are balanced in the rail track. This is a prerequisite for derailment of the vehicle. The goal of the study is to determine the additional transverse forces that arise because of the bent rails. The task is statically indeterminate, and considering the dimensions of the rails, its solution becomes seriously difficult. For the purposes of the study, the finite element method was used. Based on the displacements of the support points of the rails (caused by the geometry of the curve) the bending line of the elastic load is determined and the forces in the supports are calculated. A group of five rails is considered, with results multiplied proportionally for cases other than five. The resulting forces are considered when determining the derailment safety criterion defined by EN 14363:2019.

Cathodic protection is widely used to protect metal structures from corrosion and is commonly applied on marine structures in seaports using sacrificial galvanic anodes. These anodes, either in Zinc, or preferen-tially nowadays in Al-Zn-In alloys, are expected to corrode instead of the metal to be protected. This leads to the release of specific dissolved species, Zn2+, Al3+, In3+ and solid phases like Al(OH)3. Few studies were conducted on the effects of anodes on marine organisms and concluded that further detailed investiga-tions are needed in controlled environments. We therefore propose an experimental approach to evaluate the effects of Zn and Al-Zn-In anodes on oysters stabulated in tanks, under conditions approaching those used in the ports. We chose a non-targeted metabolomic approach, using UHPLC coupled to HRMS, to study the effects on the entire metabolome, without any a priori. A modelling study of the chemical species, corresponding to the deg-radation products of the anodes, likely to be present near the exposed oysters, was also included. We identified 16 and 2 metabolites modulated by Zn- and Al-Zn-In-anodes respectively, involved in bi-ological functions, such as energy metabolism, osmoregulation, oxidative stress, lipid, nucleotide nucle-oside and amino acid metabolisms, defense and signaling pathways.

The maritime industry contributes to over 80% of global trade and ranks as the sixth-largest emitter of greenhouse gases. The International Maritime Organization has taken strides to reduce these emissions, while the European Union spearheads efforts to establish sustainable maritime transport. However, meeting decarbonisation targets poses significant challenges, with the potential implications of adopting an EU Emission Trading System (ETS) on shipping allowances, particularly at specific borders. If not managed effectively, this could result in diversifying regular container shipping routes away from EU ports, potentially leading to increased shipping emissions and disrupting the logistics trade and security chain. These challenges are exacerbated by the International Maritime Organization's lack of a carbon fee on bunkering, which creates an imbalance. The ETS Directive has fostered unfair competition between EU and non-EU ports due to discrepancies in applying emission unit allowances. It is imperative to implement preventive measures to contain and prevent the shift of operations from EU ports to nearby ports, ensure equitable treatment of EU transhipment ports and their competitors, and thwart carbon leakage. Additionally, the recent Houthis attacks on the Red Sea have significantly impacted shipping costs on the Cape of Good Hope route to Europe, necessitating increased allowances to and from Europe.

The composite post insulator composed of a large diameter mandrel and flange pressed by one-time integral pultrusion has high strength and good toughness, widely used in the existing flexible converter valve. For constructing the finite element model of the crimped post insulator, most of the flange surface and the mandrel surface are directly connected, making the simulation model's stiffness deviate from the actual model and the model distortion. Based on this, this study proposes a new finite element simplified model of crimped composite post insulator based on Multi-Point Constraints (MPC), which accurately simulates the crimping area of man-drel and flange in engineering practice. It verifies the model's reliability through static tests and characteristic vibration tests. The results show that the difference between the finite element simulation and test results is within 5 %. The finite element modeling method based on MPC local constraints is very reliable in applying crimped composite post insulators. Based on the proposed model, the influence of flange height and thickness on the mechanical properties of composite post-insulators is further explored. The results show that the influence of flange height on mechanical properties can be ignored when the height of the insulator stiff-ener ( non-press common area ) is constant. Within the allowable thickness range of the flange crimping process, the increase in flange thickness will significantly reduce the maximum bend-ing stress of the insulator and increase its safety margin. It provides a good design idea for the design of crimping composite insulators.

Near-neutral pH and low redox potentials (EH) are considered favorable conditions for radionuclides immobilization in deep repository systems in clay geological formations. Cigeo is a future Industrial Centre for Geological Disposal for Nuclear Waste (NW) for high-level and intermediate level long-lived radioactive waste, to be built in France, at 500 m depth within the Callovo-Oxfordian clay formation. Deep knowledge of the mechanisms and kinetics of corrosion occurring at the external surface of tubings made of API 5L X65 carbon steel (CS-X65) in contact with COx pore water, is essential for a reversible NW management of the Cigeo site. By using robust handmade electrodes and electrochemical and gravimetric techniques, this work aimed to determine the corrosion phenomenology and kinetics of CS-X65 in contact with COx pore water flowing continuously through a Multi-Parameter Probe (MPP) device, placed at 500 m depth, for more than 180 days. It also aimed at demonstrating the reliability and the robustness of the measurement methodology for the corrosion evaluation of the metallic liner of the future nuclear waste disposal site. Two iron oxidants were encountered, oxygen, who was depleted, and proton, who was accompanied by hydrogen sulfide. Corrosion mechanisms and kinetics were well established for two CS-X65, electrochemically perturbed and not. The corrosion thickness loss rates stand between 0.016 and 0.032 mm/y.

To learn what mothers know on newborn bloodspot screening (NBS), the procedure, and sources used, a pilot study was performed. An online questionnaire was developed, with a first part fo-cused on characteristics and the NBS procedure, a second on knowledge, information sources, and health care providers (HCP). This questionnaire was accessible until 200 answers were received. Characteristics of respondents were representative for the population. Mothers recalled verbal consent in 69.5%, 12.5% did not, 18% stated that no consent was requested. The ‘knowledge’ part contained 12 closed questions, 5 multiple-choice questions on sources, and assessment (5-point Likert) of the information transfer. The mean knowledge level was 7.2/12. Screening concepts (consequences, likelihood, sensitivity, carrier) and absence of notification of normal findings were well known. The fact that NBS is not compulsory and post-analysis sample handling were poorly known. Key HCPs were midwifes (80.5%) and nurses (38.5%). When the leaflet (44%) was pro-vided, the majority read it. Mean Likert scores were 3.36, 3.38, 3.11 and 3.35 (clarity, timing ap-propriateness, sufficiency, usefulness). The knowledge level and consent practices were reasonable well. Key HCP were midwives and nurses, leaflets were supporting. This should enable a quality improvement program to a sustainable NBS program in Flanders.

The effect of γ-ray irradiation on surface plasmon resonance (SPR) sensing capability of refractive index (n = 1.418–1.448) of the silica glass optical fiber comprised of germano-silicate glass cladding embedded with Au nano-particles (NPs) was investigated. As the γ-ray irradiation increased from 1 hour to 3 hours with the dose rate of 1,190 Gy/h, the morphology of the Au NPs and the SPR spectrum were found to change. The average diameter of Au NPs increased with the aspect ratio from 1 to 2 and the nano-particles became grown to the clusters. The SPR peak wavelength shifted towards longer wavelength with the increase of total dose of γ-ray irradiation regardless of the corresponding refractive indices. The SPR sensitivities (wavelength/refractive index unit, nm/RIU) also increased from 407 nm/RIU to 3,553 nm/RIU, 1,483 nm/RIU, and 2,335 nm/RIU after the γ-ray irradiation at the total dose of 1,190 Gy, 2,380 Gy, and 3,570 Gy, respectively.

This paper proposes a linear eddy-current feature to determine the radius of a metallic ball in a non-contact manner. An electromagnetic eddy-current sensor with two coils is placed co-axially to the metal ball during measurement. It is well known that the distance between the sensor and test piece (i.e. lift-off) affects eddy-current signals. In this paper, it is found that the peak frequency feature of inductance spectrum is linear to the lift-off spacing between the centre of coil and ball. Besides, the slope of peak frequencies versus lift-offs is linked to the radius of ball. The radius of metallic balls is retrieved from the experimental and embedded analytical result of the slope. Measurements have been carried out on 6 metallic balls with different radii. The radius of the metallic ball can be retrieved with an error of less than 2 %.

Previous bio-mapping studies of pork processing facilities have indicated a need for mitigation strategies in trim and ground products due to Salmonella prevalence. Lymph nodes have been identified as a source of Salmonella in pork products. The objective of this study was to determine if the removal of glands and lymph nodes in pork would reduce Salmonella and indicator organisms in comminuted products. Samples from a commercial pork facility were divided into three treatment groups; 1) untreated control, 2) topical glands removed before final processing, and 3) topical, jowl, and internal lymph nodes and glands removed before final processing. Samples were evaluated for indicator organisms and quantity of Salmonella using the BioMérieux TEMPO® system and BAX® System Real-Time Salmonella SalQuant™ methodology, respectively. The results of this study indicate that the removal of the topical, internal, and jowl lymph nodes was effective at significantly (P > 0.05) reducing the prevalence of both Salmonella and indicator organisms. Salmonella was reduced from 2.5-Log CFU/Sample and 3.8-Log CFU/Sample of Salmonella in control group ground and trim samples, to less than 1-Log CFU/sample in both matrices from treatment 3. These data indicate that samples from treatment 3 had an average of a 3-Log reduction, and treatment 2 had a 2.5-Log reduction, of Salmonella when compared to the control samples. This indicates that the physical removal of glands and lymph nodes can influence Salmonella and indicator organism prevalence in the final product.

In this study, the biodegradation properties of leather treated with various finishing chemicals were evaluated in order to enhance the sustainability of leather processing. We applied advanced analytical techniques including FT-IR, thermogravimetric analysis (TGA), and solid-state NMR spectroscopy. Leather samples treated with different polymers, resins, bio-based materials, and traditional finishing agents were subjected to a composting process under controlled conditions to measure their biodegradability. The findings revealed that bio-based polyurethane finishes and acrylic wax exhibited biodegradability, while traditional chemical finishes like isocyanate and nitrocellulose lacquer showed moderate biodegradation levels. The results indicated significant differences in the biodegradation rates and the impact on plant germination and growth. Some materials, such as black pigment, nitrocellulose lacquer and wax, were beneficial for plant growth, while others, such as polyurethane materials, had adverse effects. These results support the use of eco-friendly finishes to reduce the environmental footprint of leather production. Overall, this study underscores the importance of selecting sustainable finishing chemicals to promote eco-friendly leather manufacturing practices.

Flails are one of the more contentious and misunderstood classes of medieval weaponry, despite their prevalence in popular media: some researchers question their existence entirely and the bulk of historians are sceptical of widespread temporal and geographical prevalence while others, and a significant volume of period evidence, would argue the contrary. While the expansive use of flails in Eastern Europe and Byzantium is familiar, many Central, Western, and Southern European sources are less well-known or largely forgotten, especially those stemming from the later-early and early-high medieval eras (up to 1250). In this work, I collate and discuss the bulk of the available literary references and artistic depictions of flails and their use alongside some of the archaeological finds from Western, Central, and Southern Europe, with an emphasis on the 12^th and 13^th Centuries. The significance of this volume of evidence is examined, and an assessment of flails as a part of medieval culture and warfare is considered. Collectively, this would suggest that knowledge of flails as instruments of war and associated cultural connotations, if not their actual prevalence and use in warfare, was far more widespread across Europe this time period than has been previously estimated.

Whereas waste management research has focused on mostly urban municipalities in South Africa, not much is known about the current performance of waste management services from the perspective of community residents in rural municipalities. This study reports on the status and effectiveness of waste management practices from the perspective of community residents in the Umkhanyakude and Zululand Districts in the rural areas of the KwaZulu-Natal province of South Africa. Making use of structured questionnaires, primary data was obtained by interviewing 333 respondents representing households in the study area. Results have revealed several shortfalls in the provision of municipal waste management services, except for solid waste removal from households (66%), and management of landfill sites (41%). The degree of dissatisfaction for waste management services rendered was very high (97.3%). Furthermore, the majority (61.4%) of respondents were not willing to participate in waste segregation due to lack of appropriate knowledge and infrastructure. The study also pinpointed some benefits associated with waste minimization, as well as barriers constraining effective waste recycling. Based on these findings, there is a dire need for transforming current waste management practices toward increased recycling rates by creating more environmental awareness and a supporting infrastructure.

The reservoir water level fluctuation zones (RWLFZs) and the natural riparian zones (NRZs) are two riparian ecosystems with the dramatically opposite hydrological rhythms which notably influence the plant guilds. However, little is known about the discrepancy of functional traits and niche characteristics of plant guilds in the RWLFZ and NRZ under different flooding rhythms. Here the RWLFZs (degraded riparian zones) and NRZs were chosen in the Xiangxi River Basin of the Three Gorges Reservoir (TGR) to investigate the variation in plant community structure, the spatial patterns of diversity, key functional traits and niche characteristics of dominant plant populations. The results showed that a total of 78 vascular plant species were identified in the riparian zones of Xiangxi River Basin. Most of the dominant species were annual herbs in the two riparian ecosystems and the percentage of annual dominant species increased from 65.79% in the NRZ to 67.34% in the RWLFZ. Compared with the NRZ, the specific leaf area, vegetation coverage and the aboveground biomass in the RWLFZ significantly increased by 74%, 27% and 19.6% respectively, while the water use efficiency of the RWLFZ decreased by 59.6% and there was no significant difference in the net photosynthetic rate between them, which showed that annuals in the RWLFZ adopt the R adaptation strategy with fast-growing, short lifespan and quickly acquiring and investing resources by altering leaf morphology such as expanding leaf area. The Simpson dominance index of RWLFZ was significantly higher than that of NRZ. Thus counter-seasonally hydrological alterations had the significant effects on functional traits of dominant species in the RWFLZ. Moreover, the highly adaptable and widely distributed species with larger niche breadths and high important values usually had a higher niche overlap value in the RWLFZ than in the NRZ, which showed that the competition in the plant community after experiencing anti-seasonal flooding was much more intraspecific than interspecific and would facilitate the expansion of species niches. And the distribution of the plant community was mainly driven by elevation (flooding depth), flooding duration and TK in the WLFZs. Our findings imply that the species with large niche breadths and high important values should be prioritized in ecological restoration efforts in the newly formed hydro-fluctuation zone of the TGR.

The high-quality development of urban-rural integration is a vital component of China's economy, serving as a strategic response to the in-depth deployment of new urbanization and rural revitalization strategies. This integration is underscored by the promotion of entrepreneurship in agriculture, rural areas, and among farmers, which acts as a driver for fostering high-quality development in urban-rural areas through market competition. The resulting influx of resources and commodities with similar characteristics plays a crucial role in bridging the urban-rural divide. To maintain objectivity, it is important to adopt a balanced approach and refrain from using biased language. This study delves into the connotation and internal mechanism of the high-quality development of urban-rural integration, centering on the principle of 'quality'. Specifically, it examines the role of entrepreneurship in agriculture, rural areas, and among farmers, and evaluates its direct impact and transmission mechanism. The research employs balanced panel data from 41 cities in the Yangtze River Delta region spanning from 2003 to 2021. The findings reveal that entrepreneurship in agriculture, rural areas, and among farmers serves as a catalyst for promoting high-quality urban-rural development through the construction of a virtuous cycle, whereby resource factors and commodity services are exchanged. Moreover, this deep integration yields diverse effects across economic, spatial, demographic, social, and ecological domains, underscoring the necessity of continued support for entrepreneurship in agriculture, rural areas, and among farmers to facilitate a seamless urban-rural economic cycle and fully realize the benefits of high-quality development.

The aim of this study was to assess precipitation (P) by analyzing data from in situ stations compared with those from solely remote sensing products CHIRP and CMORPH, with a reference station in the city. The evapotranspiration (ET) was analyzed directly using SSEBop. The region chosen for this study was the Metropolitan Area of Belem (MAB), close to the estuary of the Amazon River and the mouth of the Tocantins River. Belem is the rainiest state capital of Brazil, which causes a myriad of problems for the local population. The monthly best fit is shown here. In this study, we analyzed P and ET from local stations and compared them with those from satellite products. The main metrics RMSE, NRMSE, MBE, R2, Slope, and NS were used. For the reference station, the automatic and conventional CHIRP and CMORPH results, in mm/month, were as follows: automatic CHIRP: RMSE = 93,3, NRMSE = 0.32, MBE = −33,54, R2 = 0.7048, Slope = 0.945, NS = 0.5668; CMORPH: RMSE = 195,93, NRMSE = 0.37, MBE = −52,86, R2 = 0.6731, Slope = 0.93, NS = 0.4344; conventional station CHIRP: RMSE = 94.87, NRMSE = 0.32, MBE = −33.54, R2 = 0.7048, Slope = 0.945, NS = 0.5668; CMORPH: RMSE = 105.58, NRMSE = 0.38, MBE = −59.46 R2 = 0.7728, Slope = 1.007, NS = 0.4308. This was compared with the pixel and in situ station data. The ET ranges, on average, between 83 mm/month in the Amazonian summer and 112 mm/month in the Amazonian winter. This work concludes that, although CMORPH has a coarser resolution of 0.25° compared to CHIP’s 0.05° for MAB at a monthly resolution, the remote sensing products were reliable. SSEBop also showed reliable performance. For analyses of the consistency of precipitation time series, these products could provide more accurate information.

Background University students’ psychological health is linked to their academic satisfaction. This study aimed to investigate students’ psychological health and academic satisfaction in the context of COVID-19 and academic year-end stress. Methods Standardized self-filled scales for anxiety, depression, stress, psychological well-being, and an ad-hoc COVID-19 stress scale were used in this cross-sectional study. Participants were first- to third-year students of eight different health-related tracks in Geneva, Switzerland. Descriptive statistics and hierarchical regression analyses were applied. Results In June 2020, out of 2835 invited students, 433 (15%) completed the survey. Academic satisfaction was a stronger mental health predictor than COVID-19, which mainly predicted stress and anxiety. Lower academic satisfaction scores were significantly associated with stress (β = -.53, p < .001), depression (β = -.26, p < .001), anxiety (β = -.20, p < .001), while higher scores with psychological well-being (β = .48, p < .001). Being female was strongly associated with anxiety and stress but not with depression or psychological well-being. Lower age was associated with stress only. The nature of the academic training had a lesser impact on mental health and the academic year none. Compared to students starting the academic year, year-end students reported significantly lower academic satisfaction, higher depression, and particularly higher anxiety and stress. There was, however, no difference in psychological well-being. Conclusion Students suffer more from anxiety, stress, depression, and lower satisfaction with studies at the end of the academic year than at the beginning. Academic satisfaction plays a more substantial role than COVID-19 in predicting students’ overall mental health status. Training institutions should address the underlying factors that can enhance students’ academic satisfaction, especially during the COVID-19 period, in addition to ensuring that they have a continuous and adequate learning experience, as well as access to psychosocial services that help them cope with mental distress and enhance their psychological well-being.

Successful implementation of antibiotic stewardship programs (ASP) requires a well-structured approach involving all stakeholders. Despite embracing key responsibilities, nurses’ role remains poorly defined, preventing consistent engagement. We conducted a scoping survey to assess knowledge, attitude and perception of nurses towards nurse-led initial sepsis risk evaluation using the sepsis risk calculator (SRC) of newborns admitted to the mother-baby unit. Single-center, cross-sectional study. Study link was sent to all full-time nurses in mother-baby unit. Survey centered around knowledge of unit’s ASP and attitude and perception towards nurse-led initial sepsis risk evaluation. 89% response rate. 100% agreed that SRC reduced antibiotic use and 66% felt nurse-led sepsis risk evaluation will enhance nurse involvement, but this was offset by extra burden of work (66%) and low confidence in differentiating stable from clinically unstable infants (46%). Other facilitating factors included greater nurse/patient ratio (100%), targeted education (89%) and incorporation of the SRC into EMR (78%). Only 11% were willing to serve as champions for it. There was no significant correlation to age or experience however, greater number of fresh grads were interested in championing this effort. Our study identifies a need for strong foundation of knowledge and greater nurse/patient ratio as two main factors for improving nurse-led use of the SRC. Multi-site studies scoping barriers to nursing involvement for successful implementation of ASPs are necessary.

Droughts have a substantial effect on water resources, agriculture, and ecosystems on a worldwide scale. In the Mekong Delta of Vietnam, droughts exacerbated by climate change are significantly endangering the region's agricultural sustainability and output. Conventional forecasting techniques frequently do not capture the intricate dynamics of meteorological phenomena associated to drought effectively, prompting the exploration of more advanced methodologies. This work utilises artificial intelligence, par-ticularly machine learning methods like Gradient Boosting and Extreme Gradient Boosting (XGBoost), to enhance drought pre-diction in the Mekong Delta. The study utilises data from 11 meteorological stations spanning from 1990 to 2022 to create and evaluate Machine Learning models based on several climatic factors. We utilise Gradient Boosting and XGBoost algorithms to estimate the Standardised Precipitation-Evapotranspiration Index (SPEI) and evaluate their effectiveness in comparison to con-ventional forecasting techniques. The results show that Machine Learning, particularly XGBoost, surpasses traditional approaches in predicting SPEI accuracy at various time scales. XGBoost demonstrates skill in understanding the complex relationships between climatic factors, with R² values falling between 0.90 and 0.94 for 1-month forecasts. The progress highlights the potential of Machine Learning in improving drought management and adaptation tactics, proposing the incorporation of Machine Learning forecasting models into decision-making processes to enhance drought resistance in susceptible areas.

This publication describes the influence of residue monomers in synthesized pressure-sensitive adhesives based on acrylics on main performance such as tack, peel adhesion, shear strength and shrinkage in form of transfer tapes used for joining wooden elements in furniture industry. The discussed carrier-free adhesive tapes are synthesized by photo-crosslinking and photopolymerization with UV radiation of photoreactive prepolymers sandwiched between two adhesive siliconized polyester films. The simultaneous crosslinking and polymerization process under UV lamps carried out under UV lamps placed simultaneously above and below the crosslinked photoreactive polymer layer leads to the production of a carrier-free adhesive film. In this test series it were investigated to what how the intensity of UV radiation and the time of its exposure affect the viscosity of photoreactive compositions, and then the content of unreacted monomers in them and, subsequently, the method of their crosslinking and polymerization, and the concentration of the photoreactive crosslinking compound leading to the obtaining of transfer adhesive tapes, and thus on their tray, peel adhesion, shear strength and shrinkage on the surface of the wood.

The growing emphasis on carbon considerations and the pursuit of net-zero emissions have brought about a paradigm shift in project management. To successfully facilitate the transition towards net-zero emissions, major projects must not only adapt existing systems but also embed carbon targets into their core strategies. While several studies have investigated carbon integration during the procurement phase, limited attention has been given to the construction project manager (PM) perspective. This study aims to bridge this research gap by exploring the challenges and barriers faced by construction PMs when integrating carbon targets and metrics into major Architectural, Engineering and Construction (AEC) projects, as well as evaluating the readiness of project teams to deliver on these. The study deployed a qualitative exploratory research design, where semi-structured interviews were conducted with 17 AEC project professionals actively engaged in the planning and execution of major projects in the UK. Thematic analysis of the data revealed a range of challenges and barriers faced by PM teams delivering these projects. The research findings contribute to the field of construction PM by enhancing the understanding of the challenges faced by project managers and project teams when integrating carbon requirements into the delivery of major projects. It uncovers a series of challenges and prevalent practices in major projects that have the potential to impede progress towards the net-zero transition.

Purpose: To explore the clinical relationship between age, interocular differences in the corrected distance(CDVA) and near(CNVA) high contrast logMAR acuities, refractive errors, aniseikonia, axial lengths, pupil sizes, and higher order ocular aberrations (HOAs) on clinical measures of stereoacuity in asymptomatic, presbyopic, habitual spectacle wearers. Methods: 91 subjects underwent clinical assessment of i)subjective refractive error, ii)stereoacuity[arcsecs] at 6m&40cm(Randot Stereotests), iii)aniseikonia[%] at 6m (Awaya test,vertical and horizontal meridia) iv)higher order aberrations(Hartman-Shack aberrometer) v)eyeball length and pupil size(IOL master 700). The resultant aniseikonia(AR) was calculated for pairs of aniseikonia values using Pythagorean theorem. Results: Mean(±sd,95%CI) age of the subjects was 56.2years(±8.10,54.6-57.9). Root mean square(RMS) interocular differences(±sd,95%CI) in spherical refractive errors, axial lengths and pupil sizes were 0.66D(±0.93,0.47-0.85), 0.24mm(±0.33,0.17-0.31), 0.15mm(±0.11,0.12-0.17). Median(mode,interquartile range) values for AR were 2.8(1.0,1.3-4.0). Significant correlations(p

Methyl Salicylate (MS), the principal constituent of Wintergreen oil (WO) was obtained from acetyl salicylic acid (ASA) by sequential transesterification-esterification reaction promoted by NbCl5for the first time. The reagents were added simultaneously, and the reaction process involved the transesterification and esterification reactions, which were accompanied by thin layer chromatography and gas chromatography. The conversion rate via GC was 100%, and the MS yield was 94%. A cytotoxicity of 50% and 64% for cultured S. aureus and metastatic melanoma cells, respectively, was observed for a concentration of 0.6 mg/mL, whereas no cytotoxicity for non-tumor cells was observed for this concentration, and it is considered to be the optimum concentration.

In recent years, given the enormous competition for new products and services, many companies have begun to behave more creatively in an aim to be the best in the market. “Guerrilla marketing” refers to an advertising technique that uses unconventional and cost-effective approaches, employing a variety of strategies that reduce costs. Since the emergence of this concept in the second half of the last century, substantial research has looked into its application and usefulness. This study presents a systematic survey of the field of marketing and advertising: by analyzing the main scientific publications on guerrilla marketing through content analysis in the Web of Science, Scopus, and EBSCO databases. One hundred and sixty-four articles were analyzed in depth and divided into two separate lists: one with publications corresponding to Hutter and Hoffmann’s first classification, and another corresponding to the new variables that emerged from the in-depth study that was carried out. As a consequence, a new taxonomy is proposed for the field, based on the identification of some novel variables characterizing the different existing approaches.

Soil erosion and sediment transport are quite complex processes as they depend on physical, biological, mechanical, and chemical processes within a particular catchment. Therefore, it is highly essential to better explain engaged physical processes and means of accounting for site-specific conditions, for soil loss and sediment yield estimation. This paper mainly focuses on physical explanations behind soil erosion and common soil erosion models like Universal or Revised Universal Soil Loss Equation(USLE/RUSLE) and Modified Universal Soil Loss Equation(MUSLE). Based on the physical explanations and overall limitations, the MUSLE is selected for the application of sediment yield estimation. The main objective of this paper is to estimate the best exponent of the MUSLE, and to estimate the best combination of the exponent and topographic factor of the MUSLE under hydro-climatic conditions of Ethiopia. For the sake of calibration procedure, the main parameters of the MUSLE which directly affect soil erosion process such as cover, conservation practice, soil erodibility, and topographic factors are estimated based on the past experiences from literature and comparative approaches, whereas the other parameters which do not directly affect the erosion process or which have no any physical meaning (i.e coefficient a and exponent b) are estimated through calibration. It is verified that the best exponent of the MUSLE is 1 irrespective of the topographic factor, which results in the maximum performance of the MUSLE (i.e approximately 100\%). For the best combination of the exponent and topographic factor, the performance of the MUSLE is greater than or equal to 80\% for all four watersheds under our consideration, we expect the same for other watersheds of Ethiopia.

Social distancing, washing hands and good hygiene are essential and currently the most potent methods available to curb down the unprecedented speed by which the new coronavirus is spreading across the globe. Even under lockdown, which is necessary to significantly reduce the number of people that get infected by an ill person, are there additional measures that each of us can embrace to even further reduce the risk of infection and the severity of the COVID-19 disease? Given the lack of licensed drugs that target SARS-CoV-2 specifically, we have to look into additional non-specific defense mechanisms that animals and humans evolved to protect themselves from pathogen invasions. The goal of this article is to describe how various of our non-specific defense mechanisms work, which actually precede the inflammatory response, and to discuss whether we can exploit the unique features of the coronavirus envelope and the self-cleaning machinery of the human respiratory tract to strengthen our self-defense. The challenge is to actively interfere with supportive measures during the short time window between getting exposed and before an inflammatory response gets initiated.

As climate change should lead to an increase in the vulnerability and the sensitivity of forests to extreme climatic events, quantifying and predicting their response to more severe droughts remains a key task for foresters. Furthermore, recent works have suggested that tree diversity may affect forest ecosystem functioning, including their response to extreme events. In this study we aimed at testing whether the growth response of forest stands to stressful climatic events varied between mixed and monospecific stands, under various environmental conditions. We focused on beech-fir forests (Fagus sylvatica [L.] and Abies alba [L.]) and beech-oak forests (Fagus sylvatica [L.] and Quercus pubescent [L.]) in the French Alps. We used a dendrochronological dataset sampled in forest plots organized by triplets (one mixture and two monospecific stands) distributed in six sites along a latitudinal gradient. We tested (1) whether stand diversity (two-species stands vs monospecific stands) modulates the stands’ response to drought events in terms of productivity, (2) whether species identity may drive the diversity effect on resistance and recovery, and (3) whether this can be explained by interspecific interactions. We found that (1) interspecific differences in response to extreme drought events (possibly due to interspecific differences in hydraulic characteristics) can induce a mixture effect on stand growth, although it appeared (2) to be strongly depending on species identity (positive effect only found for beech-fir mixed stands), while (3) there were no significant non-additive effects of diversity on stand resistance and recovery, except for some specific cases. Overall, our study shows that promoting selected mixed stands management may buffer extrem drought effect on stand productivity.

In this paper, we study a differential operator of parabolic type with a variable and unbounded coefficient, defined on an infinite strip. Sufficient conditions for the existence and compactness of the resolvent are established, and an estimate for the maximum regularity of solutions of the equation Lu=f∈L_2(Ω) is obtained. Two-sided estimates for the distribution function of approximation numbers are obtained. As is known, estimates of approximation numbers show the rate of best approximation of the resolvent of an operator by finite-dimensional operators. The paper proves the assertion about the existence of positive eigenvalues among the eigenvalues of the given operator and finds two-sided estimates for them.

This study evaluated the grain size and high organic content from drinking water treatment sludge (DWTS) in the properties of ceramics. Samples were studied using raw and oven dried DWTS at 110 °C in two granulometries (0.180 mm and 0.075 mm), with and without calcination (550 °C), as partial replacement of two soils commonly used in ceramic production. Specimens were prepared with 5, 10, and 20% DWTS and calcined at 950 °C to determine their chemical, physical, mineralogical and mechanical properties. The DWTS reduced the density and increased the absorption and shrinkage of the specimens after calcination. An increase in strength with up to 10% sludge, driven by the presence of fluxing agents, was verified. The processing method had little influence on the properties of ceramic with above 10% of sludge. In conclusion, the use of raw DWTS obtained better results with low energy usage for its reuse.

The transport and entanglement of photons is becoming prominent in optics applied to information and quantum computing, where the angular momentum of light stands out in the exchange and inversion of quantized states, with prospects for several technological applications, such as the transport and storage of quantum information. In order to contribute to the understanding of quantized states in photon-matter interaction, we describe a quantized state equation in multidimensional Hilbert space for the diagnosis of OAM states, where probabilities arise in a relativistic setting. It was found that the classical-relativistic variability of the probabilities constitutes a resultant capable of describing the quantized states of light, where the state variable is the variation of the angular momentum of the photon, capable of estimating the orbital angular momentum inversion points at angular incidence. It was found that the chances of finding the quantized states of light at angular incidence can be treated by purely relativistic probabilities, explaining that when both states have equal chances of being found and the angular momentum variation is zero, the source-observer synchronizations occur at the step of increasing relativistic regime of the photon dynamics. We found that the relativistic effect from the perspective of the source referential is able to alter the chances of an event occurring, dilating and contracting the probabilities of finding a quantized state of light at angular incidence.

Sufficient evidence is currently available to demonstrate the reality of the warming of our planet's climate system. Global warming has different effects on climate at the regional and local levels. The detection of changes in extreme events using instrumental data provides further evidence of such warming and allows for the characterization of its local manifestations. The present study analyzes changes in temperature and precipitation extremes in the Mexican state of Zacatecas using climate change indices developed by the Expert Team on Climate Change Detection, Monitoring and Indices (ETCCDI). We studied a 40-year period (1976-2015) using annual and seasonal time scales. Maximum and minimum temperature data were used, as well as precipitation statistics from the Mexican climatology database (CLICOM) provided by the Mexican meteorological service. Weather stations with at least 80% of data availability for the selected study period were selected; these databases were subjected to quality control, homogenization, and data filling using Climatol, which runs in the R programming language. These homogenized series were used to obtain daily grides of the three variables at a resolution of 1.3 km. Results reveal important changes in temperature-related indices, such as the increase in maximum temperature and the decrease in minimum temperature. Irregular variability was observed in the case of precipitation, which could be associated with low-frequency oscillations such as the Pacific Decadal Oscillation and the El Niño–Southern Oscillation. The possible impact of these changes in temperature and the increased irregularity of precipitation could have a negative impact on the agricultural sector, especially given that the state of Zacatecas is the largest national bean producer. The most important problems in the short term will be related to the difficulty of adapting to these rapid changes and the new climate scenario, which will pose new challenges in the future.

For the polymer electrolyte fuel cell (PEFC), the separator thickness plays an important role to determine the weight, the volume and the costs of the PEFC. In addition, thermal management, i.e. temperature distribution is also important for the PEFC system to obtain higher performance. However, there were few reports investigating the relationship between the temperature distribution and the power generation performance such as current density distribution of PEFC operated at higher temperature (HT-PEFC). The aim of this study is to clarify the impact of separator thickness on the relationship between the temperature distribution and the current density distribution of HT-PEFC. This study has also investigated the impact of separator thickness on the relationship between the temperature distribution and the gases such as H2, O2 and the current density distribution of HT-PEFC numerically using CFD software COMSOL Multiphysics. The separator thicknesses of 2.0 mm, 1.5 mm and 1.0 mm were studied. In the study, the operation temperature and the relative humidity (RH) of supply gas were also changed. As a result, it was revealed that the optimum separator thickness was 2.0 mm to obtain higher power generation of HT-PEFC. Since the heat capacity in the case of the separator thickness of 2.0 mm was the largest among the separators investigated in this study, the dehydration of PEM and catalyst layer was smaller compared with the thinner separator thicknesses. It was also revealed that the impacts of separator thickness on distribution of gases, e.g. O2, H2O, and current density distribution became larger under higher temperature and lower RH conditions. This study also concluded that the tendency of temperature distribution matched those of O2, H2O and current density distributions.

A genome represents the complete collection of genetic material in an organism or cell. This genetic information is encoded in nucleic acids, which can be either single or double-stranded and arranged in linear or circular forms. DNA, the most common type of genetic material, consists of just four nucleotides: adenine, guanine, thymine, and cytosine. These nucleotides are organized in a double helix structure, a discovery made by Watson and Crick. The sequence of these nucleotides forms the basic blueprint of a gene or genome. The process of determining this sequence is known as genome sequencing. The field of genome sequencing has evolved dramatically over time, advancing from sequencing short DNA fragments to analyzing millions of base pairs. Initially, efforts were focused on determining the sequence of individual genes, but now whole genome sequencing is both rapid and widely accessible. Recent improvements in sequencing technology emphasize faster, more accurate results, lower costs, and better data analysis. Sanger sequencing, which became the gold standard for DNA sequencing for about thirty years, was instrumental in completing various genome sequences, including the human genome. It laid the groundwork for newer sequencing methods. Today, these newer methods, known collectively as “Next-Generation Sequencing” (NGS), include several generations of technology. Second-generation methods, such as Illumina, Pyrosequencing, ABI/SOLiD, and Ion Torrent Sequencing, and third-generation methods like PacBio and Helicos Sequencing, have advanced the field further. Fourth-generation technology, such as Nanopore sequencing, is also emerging. Most modern research now relies on NGS for analyzing biological sequences, and understanding these technologies offers insight into current methods and future developments.

The classical limit definition of a derivative is expressed in a more general form. The general form includes two arbitrary functions of the parameter for which the limit is calculated. A special case of the general form, which includes scaling and translational symmetry transformations of the limiting parameter, is also discussed. The errors in using the classical definition and the generalized form are calculated for small values of the limiting parameter. The derivatives of some known functions are proven using the new definition. For some well-known functions, a suitable selection of the generalized form may introduce simplicity in calculating the derivatives.

We changed the symmetry of the Weak Force from SU(2) to the quaternion group $Q_8$, and found that spin spacetime separates into two complementary spaces: a spin polarization spacetime of even parity states, and a spin coherence space, in the $S^3$ hypersphere, of odd parity coherent states. Under the quaternion group, spin is a boson of spin 1 in free flight and a fermion of spin $\frac{1}{2}$ when measured. It immediately follows that neutrinos are not needed to balance spin and conserve energy in beta decay. Additionally, we find the boson electrons emitted in beta decay are odd to parity, leading to parity conservation even though the observed beta distribution is asymmetrical.

People have long had a problem: the equations of motion that reflect the laws of physics are invariance under time inversion, while there always are irreversible processes for gases compose of microscopic particles. This article solves this problem. The point is that we should distinguish between the concepts of the equation of motion and motion. We also need to distinguish between the concepts of time-inverse motion and reverse motion. The former is anticlockwise, which is a frictional motion, while the latter is clockwise. For the single-particle motions in classical mechanics and in quantum mechanics, we present mathematical expressions for time-inversion motion and reverse motion, respectively. We demonstrate that single-particle motion is irreversible. The definition of the reversibility of two-particle collisions is given. According to the definition, the two-particle collision as a microscopic motion processes is irreversible. Consequently, for a gas consisting of a large number of particles colliding with each other, its movement should be irreversible, unless the condition of detailed balance is met. We give a physical explanation for the detailed balance, which does not concern the meaning of microscopic reversibility. The detailed balance means that after a pair of reciprocal collisions occur, the distribution function of the particles remains unchanged. Therefore, microscopic two-particle collision events are irreversible, but the statistical average of a large number of collision events makes it possible for the macroscopic process of a gas to be reversible. Conclusively, we clarify the microscopic mechanism of the irreversible process of gases.

The article was devoted to topics related to the courier market, electromobility and renewable energy sources. This is the direction in which the car market is currently heading. The current situation of transport in Poland and the electrification trends of the courier market in Poland and beyond were presented and discussed. The article presents the conducted research and analyzes it for a selected company, which at the same time constituted the achievement of the goal and the solution of the research problem. Much attention was focused on conducting AHP analysis and simulating route changes for selected regions. The study contains an introduction and a summary discussing the most important conclusions.

The Collatz conjecture (or 3n+1 problem) has been explored for about 86 years. In this article, we prove the Collatz conjecture. We will show that this conjecture holds for all positive integers by applying the Collatz inverse operation to the numbers that satisfy the rules of the Collatz conjecture. Finally, we will prove that there are no positive integers that do not satisfy this conjecture.

The incidence of breast cancer and therefore need for breast reconstruction is expected to increase. The many reconstructive options available and the changing aspects of the field make this a complex area of plastic surgery, requiring knowledge and expertise. Two major types of breast reconstruction can be distinguished: Breast Implants and Autologous Flaps. Both present advantages and disadvantages. Autologous fat grafting is also commonly used. MRI is the modality of choice for evaluating breast reconstruction. Knowledge of the type of reconstruction is preferable to provide the maximum of pertinent information and avoid false positives. Early complications include seroma, hematoma, and infection. Late complications depend on the type of reconstruction. Implant rupture and implant capsular contracture are frequently encountered. Depending on the implant type, specific MRI signs can be depicted. In case of myocutaneous flap, fat necrosis, fibrosis and vascular compromise represent the most common complications. Late cancer recurrence is much less common. Rare reported late complications include breast implant associated large cell anaplastic lymphoma (BIA-ALCL) and, recently described and even rarer, Breast implant-associated squamous cell carcinoma (BIA-SCC). In this review article, the various types of breast reconstruction will be presented, with emphasis on pertinent imaging findings and complications.

In recent years, the number of mole species for which the species status has been confirmed using genetic methods has been continuously increasing. Unfortunately, cytogenetic analysis is not available for all species. Here, for the first time, a GTG-banded karyotype of the small-toothed mole from Vietnam, Euroscaptor parvidens, a representative of the eastern clade of the genus Euroscaptor, was described. Through comparative analysis of available Euroscaptor (E. parvidens, E. klossi, and E. malayana) and Oreoscaptor (O.mizura) karyotypes we find cytogenetic signatures. Zoo-FISH with sorted chromosomes of the Siberian mole Talpa altaica on chromosome sets of the small-toothed mole E. parvidens, the small Japanese mole M. imaizumii from the close genus Mogera and the Japanese shrew mole Urotrichus talpoides from the tribe Urotrichini made it possible to identify syntenic regions between species that diverged about 35 million years ago. The low rate of chromosomal changes within the species of the genus Talpa - T.altaica and T.europaea - and the high rate of karyotypic reshuffling within the Asian genera of the tribe were confirmed. The pericentric inversions on four pairs of autosomes are shared between the closely related genera Euroscaptor, Oreoscaptor, and Mogera, while many more apomorphic rearrangements have occurred in each lineage additionally. The highest rate of chromosomal changes was recorded in the lineage of the small-toothed mole.

The concept of “hyperferritinemic syndrome” defines a complex pathophysiological and clinical entity, characterized by a systemic hyperinflammatory state, generally associated with elevated levels of proinflammatory cytokines (hypercytokinemia) and high serum levels of ferritin (hyperferritinemia), traditionally recognized as an iron-binding plasma protein involved in the storage of iron in a biologically available form for different physiological cellular processes. Recent studies have shown that ferritin has other important functions as well, operating both as a proinflammatory mediator and as a immunosupressive agent, its elevated levels in the serum being detected in various conditions associated with inflammatory states, such as infectious diseases, autoimmune and autoinflammatory disorders and, in some cases, in malignancies. Catastrophic antiphospholipid syndrome (cAPS), systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still’s disease (AOSD) and acquired forms of hemophagocytic lymphohistiocytosis (HLH), which includes macrophage activation syndrome (MAS), have been associated with hyperinflammatory states and dramatic elevations of serum ferritin, generating hyperferritinemic syndromes. Severe forms of coronavirus disease-2019 (COVID-19), in which MAS may frequently develop, has also been linked to the development of a hyperferritinemic syndrome. This review offers several insights into the physiological and pathophysiological roles of ferritin in several (hyper-)inflammatory diseases, but also into the causal entities, the underlying pathophysiological mechanisms, clinical manifestations and diagnostic features of somewhat obscure, yet potentially fatal pathological conditions, reunited under the concept of hyperferritinemic syndromes.

Luminous fungi have long attracted public attention in Japan, from old folklore and fiction to current tourism, children’s toys, games and picture books. At present, 25 species of luminous fungi have been discovered in Japan, which correspond to approximately one-fourth of the globally recognized species. This species richness is arguably thanks to the abundant presence of mycophiles looking to find new mushroom species and the tradition of night-time activities, such as firefly watching, in Japan. Bioluminescence, a field of bioscience focused on luminous organisms, has long been studied by many Japanese researchers, including the biochemistry and chemistry of luminous fungi. A Japanese Nobel Prize winner, Osamu Shimomura (1928-2018), has primarily focused on the bioluminescence system of luminous fungi in the latter part of his life, and the total elucidation of the mechanism was finally accomplished by an international research team with representatives from Russia, Brazil, and Japan in 2018. In this review, we focused on multiple aspects related to luminous fungi of Japan, including myth, taxonomy, and modern sciences.

The holographic principle states that the information about the volume of space is stored on its boundary. Assuming this holds, we can explain the aspects of gravity. The spacetime needs to be extended to 5D to explain gravity in this context. This naturally explains the four classical tests of gravity namely the gravitational redshift, the perihelion precession, the bending of light, and the gravitational time delay. We also show a novel way in which the universe expands in an accelerated manner at late times without the need for any form of dark energy.

Canada has committed to reducing greenhouse gas (GHG) emissions by increasing the non-emitting share of electricity generation to 90% by 2030. As solar energy costs have plummeted, agrivoltaics (co-development of solar photovoltaic (PV) systems and agriculture) provide an economic path to these goals. This study quantifies agrivoltaic potential in Canada by province using geographical information system analysis of agricultural areas and numerical simulations. Systems modeled would enable conventional farming of field crops to continue (and potentially increase yield) by using bifacial PV for single-axis tracking and vertical system configurations. Between a quarter (vertical) to more than one third (single axis tracking) of Canada’s electrical energy needs can be provided solely by agrivoltaics using only 1% of current agricultural lands. These results show that agrivoltaics could be a major contributor to sustainable electricity generation and provide the ability for Canada to render the power generation sector net zero/GHG emission free. It is clear that the potential of agrivoltaic-based solar energy production in Canada far outstrips current electric demand and can thus be used to electrify and decarbonize transportation, heating, expand economic opportunities by powering the burgeoning computing sector, and export green electricity to the U.S. to help eliminate their dependence on fossil fuels.

Consciousness is usually perceived as a state of being aware of one’s environment as well as self. Despite its omnipresence in our life, understanding this concept is challenging. This has given rise to several theories attempting to explain the nature of consciousness, as well as hard and soft problems of consciousness. In fact, the boundaries of consciousness defined by these theories are a topic of continued discussion, particularly in light of the recent advances in artificial intelligence (AI). Some of these theories consider consciousness as a simple integration of information while others purport the need for an agency in the process of integration for an entity to be considered conscious. Some theories consider consciousness as a graded entity and some equate consciousness with content of awareness. In this work, major theories of consciousness are reviewed and compared, focusing on awareness, attention, and sense of self. These findings are interpreted in relation to AI in order to ascertain what makes AI distinct from natural intelligence.

We survey the main results emerging in the rapidly developing field that considers the geometry of thermodynamics and statistical mechanics. Our ideas of stability depend on variational principles – Maximum Entropy together with Least Action (and the isomorphic Least Exertion) – and this stability (invariance in time) indicates the centrality of the geometries of the systems. We explore a variety of examples of the application of thermodynamics in both macro- and micro-systems, and propose that irreversibility is an intrinsic and fundamental property of the physical realm (instead of being merely emergent). Using the concept of complex time, we examine the underlying mathematical unity of quantum mechanics, statistical mechanics, and geometrical thermodynamics. We show how the Planck and Boltzmann constants provide the fundamental quantum units for the phenomenological characteristics of the two Noether-conserved quantities controlling overall thermodynamic behaviour: respectively, energy and entropy production. We discuss the far-reaching isomorphisms (between all of complex time, temperature and the system symmetry) that always exist for Maximum Entropy systems, even as they exhibit either irreversible (dissipative, yet still dynamically stable) or reversible (including stable and static geometries) behaviours.

This article presents an estimation of the hypertension risk based on a dataset on 1007 individuals. The application of a Tobit Model shows that “Hypertension” is positively associated to “Age”, “BMI-Body Mass Index”, and “Heart Rate”. The data show that the element that has the greatest impact in determining inflation risk is “BMI-Body Mass Index”. An analysis was then carried out using the fuzzy c-Means algorithm optimized with the use of the Silhouette coefficient. The result shows that the optimal number of clusters is 9. A comparison was then made between eight different machine-learning algorithms for predicting the value of the Hypertension Risk. The best performing algorithm is the Gradient Boosted Trees Regression according to the analyzed dataset. The results show that there are 37 individuals who have a predicted hypertension value greater than 0.75, 35 individuals who have a predicted hypertension value between 0.5 and 0.75, while 227 individuals have a hypertension value between 0.0 and 0.5 units.

After proving, in a purely categorial way, that the inclusion functor InAlg(Σ) from Alg(Σ), the category of many-sorted Σ-algebras, to PAlg(Σ), the category of many-sorted partial Σ-algebras, has a left adjoint FΣ, the (absolutely) free completion functor, we recall, in connection with the functor FΣ, the generalized recursion theorem of Schmidt, which we will also call the Schmidt construction. Next we define a category Cmpl(Σ), of Σ-completions, and prove that FΣ, labeled with its domain category and the unit of the adjunction of which it is a part, is a weakly initial object in it. Following this we associate to an ordered pair (α,f), where α=(K,γ,α) is a morphism of Σ-completions from F=(C,F,η) to G=(D,G,ρ) and f a homomorphism in D from the partial Σ-algebra A to the partial Σ-algebra B, a homomorphism ΥαG,0(f):Schα(f)B. We then prove that there exists an endofunctor, ΥαG,0, of Mortw(D), the twisted morphism category of D, thus showing the naturalness of the previous construction. Afterwards we prove that, for every Σ-completion G=(D,G,ρ), there exists a functor ΥG from the comma category (Cmpl(Σ)↓G) to End(Mortw(D)), the category of endofunctors of Mortw(D), such that ΥG,0, the object mapping of ΥG, sends a morphism of Σ-completion in Cmpl(Σ) with codomain G, to the endofunctor ΥαG,0.

Childhood obesity is a preventable multi-systemic disease that has become an epidemic. In this narrative review, we showed evidence, in the literature, of the affectation of body systems by obesity. Co-morbid conditions of obesity in the cardiovascular, nervous, dermatological, respiratory, endocrine, reproductive, musculoskeletal, gastrointestinal, and renal systems, and its effects on mental health are discussed. Obesity ultimately reduces the quality of life of children and is a leading cause of preventable deaths. Effective measures aimed at the prevention of obesity and the treatment of its co-morbid conditions should be taken.

Viruses were classically named after the very same Latin word virus, originally meaning poison or venom. Public understanding of viruses reinforces their “malign” aspects, especially nowadays under the COVID-19 global pandemic. It is our aim here to propose a new way to view viruses and understand their origins and evolution. First, viruses are the most abundant biological systems found on Earth. They can be found almost everywhere and form a subtle biological layer named virosphere. Second, viruses are probably the most important drivers of molecular evolution and they are active agents of ecosystems maintenance and homeostasis, allowing and driving their dynamic modification. A significant number of eukaryotic genomes are composed by genome elements similar to viruses and these endogenous viruses are continuously acting for our equilibrium and fitness. They are responsible for the origin of species-specific orphan genes that allow adaptation through the development of specific traits in separate lineages of eukaryotes. Accumulated evidence indicate that a viral infection was responsible to create the eukaryotic nucleus and, also, it is a syncytium structure caused by viral replication that allows the formation of the placenta. Therefore, viruses were fundamental for the evolutionary fate of eukaryotes and mammals. The presence of virus-specific genes that are absent in cellular organisms indicates that viruses existed before cells. Besides, such as progenotes, viruses are simply ribonucleoproteic entities and their capsids are orders of magnitude simpler than proteolipidic membranes. Here, we (i) propose a complete scenario to describe the major transitions in prebiotic evolution, (ii) present the possibility that viruses emerged before LUCA, and (iii) suggest that viruses originated at the age of progenotes. However, viruses do not form a monophyletic clade. They should be seen as an evolutionary stable strategy recurrently achieved by biological systems to survive. We propose that the word “VIRUS”, known as venom, is historically mistaken and introduce a new interpretation for their name as an acronym for “Very Important Replicator Unit and Symbiont”. But more than being “very important”, viruses are of “Utmost” relevance for the maintenance of life in biosphere, by which reason we suggest referring to them as “UIRUS” to reinforce their incredible role in symbiosis and their beneficial characteristics over the infectious ones.

Double-spiral galaxies are common in the Universe. It is known that the logarithmic double spiral is a Maximum Entropy geometry and represents spiral galaxies well. It is also known that the virial mass of such a galaxy can be approximately determined from the entropy of its central supermassive black hole. But over time the black hole must accrete mass, and therefore the overall galactic entropy must increase. From the associated entropic Euler-Lagrange equation (forming the basis of the Principle of Least Exertion, and also enabling the application of Nöther’s theorem) we show that the galactic entropy production is a conserved quantity, and we derive an appropriate expression for the relativistic entropic Hamiltonian of an idealised spiral galaxy. We generalise Onsager’s celebrated expression for entropy production and demonstrate that galactic entropy production has two parts, one many orders of magnitude larger than the other, and where the smaller is comparable to the Hawking radiation of the central supermassive black hole. We conclude that galaxies cannot be isolated, since even idealised spiral galaxies have non-zero entropy production.

It is shown that the gravitational mass-energy defect could be the main cause of Big Bang energy and triggering inflation in the newborn Universe.

Abstract Unlike accelerated motion or curvalinear motion,a nonlinear motion state(non-inertial system) can be described by differential equations or the other algebric equations in axiom 2, the accelerated motion in axiom 3 can be considered to be described by using the equation of the linear and curvilinear process of the continuum extending to infinitely distance.Further, this linear and curvilinear process of the continuum is a quantitative continuum in essence as a unity of infinitely quantities and infinitely dimensions at infinite distance (infinity) relative to all orientations in which we exist. These indicates that an accelerated motion accumulates continuously started from a finite quantities, leaping to transit from finite to infinite quantities by an infinitely great accelerating force.

The origin of cancer remains one of the most important enigmas in modern biology. The prevailing paradigm has failed to grasp a comprehensive view of the disease. Naturally, therapies developed under the current assumptions are inadequate and cancer is practically an incurable disease. Meanwhile, descriptive studies continuously extend the molecular complexity of cancer without an equivalent advancement in its understanding. Furthermore, they tend to accumulate inconsistencies inexplicable under the classical view. This paper presents a compelling theory of the origin of carcinomas. By hypothesis, a series of generic events in epithelial tissues promoted by cellular aging and inflammation enables the reactivation of developmental programs. The origin of carcinomas in vivo is described as the time-ordered cell state transitions undergone by epithelial cells in the hyperplasia due to replicative senescence and inflammation towards a mesenchymal undifferentiated endogenous cell state with cancerous behavior. In support of the theory, the molecular, cellular, and histopathological evidence is critically reviewed. A plausible model for the origin of carcinomas is presented to explain the mechanism underlying carcinogenesis from an evolutive and developmental perspective. The implications of the hypothesis in the current strategies for cancer prevention and treatment are discussed along with rational alternatives and some predictions for possible experimental validation.

City Marketing has a strong tradition in Berlin, with two organisations, Berlin Partner and Visit Berlin, responsible for designing and implementing relevant strategies. Sustainability has been on and off the city marketing agenda, almost exclusively in its environmental dimension. In this article we examine the current representations of Berlin as a “sustainable city” in the official City Marketing strategies. We look at how sustainability is used and instrumentalized to create a specific city profile, and also to attract particular target groups in tourism. We propose an analysis of sustainable planning in Berlin since reunification, to show how it has moved into different directions over time and how this has (or has not) been followed by City Marketing. In this endeavour we move between the existing, and as we argue deeper and more sophisticated, environmental planning of the city on the one hand, and the reductions and simplifications of City Marketing representations on the other. Finally, we argue that there are inherent contradictions in marketing a sustainable city, where both in terms of tourism and economic development, the concept of growth seems to be reaching environmental limits.

Understanding the flow in urban environments is an increasingly relevant problem due to its significant impact on air quality and thermal effects in cities worldwide. In this review we provide an overview of efforts based on experiments and simulations to gain insight into this complex physical phenomenon. We highlight the relevance of coherent structures in urban flows, which are responsible for the pollutant-dispersion and thermal fields in the city. We also suggest a more widespread use of data-driven methods to characterize flow structures as a way to further understand the dynamics of urban flows, with the aim of tackling the important sustainability challenges associated to them.

This article integrates existing theory from distributed computing and cryptology with anecdotal material from the cryptocurrency industry, to provide a comprehensive description of the minimum requirements of the hypothetical academic blockchain. The paper argues that such a community could significantly reduce the biases and misconduct that now exist in the academic peer review process. Theory suggests such a system could operate effectively as a distributed encrypted telecommunications network where nodes are anonymous, do not trust each other, and there is minimal central authority. To incentivize the academic community to join such a proposed community, the paper proposes a pseudo-cryptocurrency called litcoin (literature coin). This litcoin-based system would create economic scarcity based on proof of knowledge (POK), which is a synthesis of the proof of work (POW) mechanism used in bitcoin, and the proof of stake (POS) mechanism used in various altcoin communities. The paper argues that the proposed POK system would enable the academic community to more effectively develop the research it finds valuable.

Spondyloarthritis comprises of a group of inflammatory diseases of the joints and spine with various clinical manifestations. The group includes ankylosing spondylitis, reactive arthritis, psoriatic arthritis, arthritis associated with inflammatory bowel disease, and undifferentiated spondyloarthritis. The exact etiology and pathogenesis of spondyloarthritis are still unknown, but five hypotheses explaining the pathogenesis exist. These hypotheses suggest that spondyloarthritis is caused by arthritogenic peptides, an unfolded protein response, HLA-B27 homodimer formation, malfunctioning endoplasmic reticulum aminopeptidases, and, last but not least, gut inflammation and dysbiosis. Here we discuss the five hypotheses and the evidence supporting each. In all of these hypotheses, HLA-B27 plays a central role. It is likely that a combination of these hypotheses, with HLA-B27 taking center stage, will eventually explain the development of spondyloarthritis in predisposed individuals.

The World economy after global crisis of 2008–2009 entered a restructuring era. It defines relevance of researches of its directions and patterns. The principles of determinism and systemic analysis are methodological basis of article. In research were used the methods of processing Big Date, as of continuous changes and the symmetric analysis of macroeconomic indicators according to databases of the IMF, WB, BIS, the Central banks and treasuries. As a result of the research it is proved that depth and globalism of recessionary processes are caused by a combination of crisis of world financial system and civilization problems. Intrinsic signs of risks in the modern economy caused by the duality of the nature of global crises have been identified. There are analyzes: the deficit of resources of the international financial institutions, a negative role of a fixed rate of Yuan, a big share of derivatives and off-balance obligations of banks, use of SPV in structures of deals, growth of debt obligations, trade wars, slowdown in the growth of the Chinese economy, aggravation of contradictions between global and national finances. The thesis is reasonable that deglobalization and dedollarization deepened this conflict, started the rollback mechanism from achievements of globalization, led to tariff wars. By means of a systematization it is proved the key directions of the restructuring of global economy: legal basis, leadership and reserve currency. On the basis of SWOT-analysis of the USA and China it was concluded that the question of leadership of one country should be excluded, but slow transition to use SDR (with a basket from 15–20 currencies) as a reserve.

We present a new perspective of the link between QED and Maxwell's equations. We demonstrate that the interpretation of $\mathbf{D}=\varepsilon_{0} \mathbf{E}$ as vacuum polarization is consistent with QED. A free electromagnetic field polarizes the vacuum, but the polarization and magnetization currents cancel giving zero source current. The speed of light is a universal constant, while the fine structure constant, which couples the electromagnetic field to matter, runs as it should.

The QBIT theory is an attempt toward solving the problem of consciousness based on empirical evidence provided by various scientific disciplines including quantum mechanics, biology, information theory, and thermodynamics. This theory formulates the problem of consciousness in the following four questions: (1) What is the nature of qualia? (2) How are qualia generated? (3) Why are qualia subjective? (4) Why does a quale have a particular quality or meaning?In sum, the QBIT theory proposes that (1) when a pack of quantum information is compressed beyond a certain threshold, a quale is generated; (2) a quale is a superdense pack of maximally entangled qubits in a pure state; (3) when information-theoretic certainty of a system about an external stimulus exceeds a particular level, the system becomes conscious of that stimulus; (4) subjectivity of consciousness is due to the fact that maximally entangled pure states are private and unshareable.

The endocannabinoid system has been found to be pervasive in mammalian species. It has also been described in invertebrate species primitive as the Hydra. Insects apparently are devoid of this otherwise ubiquitous system that provides homeostatic balance to the nervous and immune systems, as well as many other organ systems. The endocannabinoid system (ECS) has been defined to consist of three parts: 1. Endogenous ligands, 2. G-protein coupled receptors (GPCRs), and 3. Enzymes to degrade and recycle the ligands. Two endogenous molecules have been identified as ligands in the ECS to date. These are the endocannabinoids: Anandamide (arachidonoyl ethanolamide) and 2-AG (2-arachidonoyl glycerol). Two G-coupled protein receptors have been described as part of this system, with other putative GPC being considered. Coincidentally, the phytochemicals produced in large quantities by the Cannabis sativa L plant, and in lesser amounts by other plants, can interact with this system as ligands. These plant-based cannabinoids are termed, phytocannabinoids. The precise determination of the distribution of cannabinoid receptors in animal species is an ongoing project, with the canine cannabinoid receptor distribution currently receiving the most interest in non-human animals.

It has been a challenge to visualize in nature some concepts from abstract subjects such as mathematics and philosophy. Irrationality is certainly among the least comprehensive. This essay aimed to propose that irrationality is simply an illusion resulting from the human inability to grasp the full nature of reality, rather than actual continuity flaws in the fabric of existence. There are three major arguments: (1) human senses have limitations and these are likely to be extended to the intellect, (2) there are no observable existential discontinuities in everyday experience, and (3) some rational phenomena have irrational components. These arguments point towards the existence of a physical existence of irrational quantities or distances, visible to the human eye but not fully comprehended through arithmetic abstraction.

It is shown that quantum entanglement is the only force able to maintain the fourth state of matter, possessing fixed shape at an arbitrary volume. Accordingly, a new relativistic Schrödinger equation is derived and transformed further to the relativistic Bohmian mechanics via the Madelung transformation. Three dissipative models are proposed as extensions of the quantum relativistic Hamilton-Jacobi equation. The corresponding dispersion relations are obtained.

A number of experimental tests of time orientability are described as well as clear experimental signatures from non time orientability (time reversal). Some tests are well known, while others are based on more recent theoretical work. Surprisingly, the results all suggest that time is not orientable at a microscopic level; even definitive tests are positive. At a microscopic level the direction of time can reverse and a consistent forward time direction cannot be defined. That is the conclusion supported by a range of well-known experiments. The conflict between quantum theory and local realism; electrodynamics with electric charges; and spin half transformation properties of fermions; can all be interpreted as evidence of time reversal. While particle-antiparticle annihilation provides a definitive test. It offers both a new view of space-time and an novel interpretation of quantum theory with the potential to unify classical and quantum theories.

1) Background: Bipolar or manic-depressive disorder is a malign mental disease that frequently faces social stigma. Educational and thinking models are needed to increase people’s awareness and understanding of the disorder. The arts have potential to achieve this goal. 2) Methods: This paper builds on the recent use of heavy metal music as a thinking and education model. It emphasizes the artistic component of heavy metal and its potential to characterize the symptomatology during the episodes of (hypo)mania and depression and the recurrence of these episodes. Heavy metal music has diversified into subgenres that become allegorical to both the symptoms of episodes and the recurrence of bipolar cycles. 3) Results: Examples of songs are given that mirror distinct facets of the disorder. 4) Conclusion: Although the links drawn between art (music) and science (psychiatry) are inherently subjective, such connections might be used to trigger a learning process, facilitate judgment and decision-making, and induce affective reactions and memory formation in the listener. The approach may facilitate collaborative efforts and serve healthcare professionals and educators as a communication tool to aid the public’s comprehension of the disease and an associated social paradox: On one hand, bipolar disorder incurs substantial costs to society. On the other hand, it benefits from the creative artistic and scientific endeavors of bipolar individuals from which cultural and political gains may ensue.

Background: This study aims to explore children’s social information processing (SIP) as an ex-planatory mechanism in the link between parent-child relationship and children’s learning diffi-culties; (2) Methods: The sample included 115 kindergarteners (62 girls; 53 boys; Mage = 68.5 months, SD = 6.04), their parents and the school teacher. Parents reported on relationship quality with the child and teachers reported on children’s learning difficulties and school achievements. Children’s SIP was assessed with the social information processing interview – preschool version (3) Results: Mother and father relationship quality with the child associated with children’s SIP, however, only the father's but not the mother's quality of relationship with the child was associ-ated with children’s learning difficulties and school achievements. Children’s SIP mediated this latter link; (4) Conclusions: Parents’ relationship quality with the child and children’s SIP are pertinent factors in children’s learning in the early years. The father-child relationship seem to be a strong determinant of children approach to learning and achievement and may have long last-ing effect on children's mental health

Children's ability to adjust to the social rules and expectations in the educational environment is of major concern to researchers and practitioners alike. Accordingly, the main purpose of the present study was to examine predictors of children's social functioning in kindergarten with a specific focus on (a) maternal factors; and, (b) children's social cognition. Using a multi-method (self-reports and direct assessments), multi-informant (child, mother, teacher) design, we collected data from 306 kindergarten children and their mothers tapping the mother's social cognitions (general and child-related) and parenting style, and children's social cognition (social information processing) and functioning in kindergarten. We found direct associations between the mother and child's social cognitions, between the mother's authoritarian parenting style and her child's less competent social cognition and behavior, and between the child's social cognition and social functioning. Finally, as hypothesized, we found a number of interesting mediated effects. Most notably, we found that the association between the mother's social cognition (her tendency to attribute hostile intent to unknown others) and the child's social cognition (his/her tendency to generate less competent responses) is fully mediated by the mother's higher levels of authoritarian parenting style. The important theoretical and clinical implications of our findings are discussed.

As the understanding of natural gas hydrates as a vast potential resource deepens, their importance as a future clean energy source becomes increasingly evident. However, natural gas hydrates tend to secondary generation during extraction and transportation, leading to safety issues such as pipeline blockages. Consequently, developing new and efficient natural gas hydrate inhibitors has become a focal point in hydrate research. Kinetic Hydrate Inhibitors (KHIs) offer an effective solution by disrupting the nucleation and growth processes of hydrates without altering their thermodynamic equilibrium conditions. This paper systematically reviews the latest research progress and development trends of KHIs for natural gas hydrates, covering their development history, classification, and inhibition mechanisms. It particularly focuses on the chemical properties, inhibition effects, and mechanisms of polymer inhibitors such as polyvinylpyrrolidone (PVP) and polyvinylcaprolactam (PVCap). Studies indicate that these polymer inhibitors provide an economical and efficient solution due to their low dosage and environmental friendliness. Additionally, this paper explores the environmental impact and biodegradability of these inhibitors, offering guidance for future research, including the development, optimization, and environmental assessment of new inhibitors. Through a comprehensive analysis of existing research, this work aims to provide a theoretical foundation and technical reference for the commercial development of natural gas hydrates, promoting their safe and efficient use as a clean energy resource.

Episcopic imaging using techniques such as High Resolution Episcopic Microscopy (HREM) and its variants, allows biological samples to be visualized in three dimensions over a large field of view. Quantitative analysis of episcopic image data is undertaken using a range of methods. In this systematic review, we look at trends in quantitative analysis of episcopic images and discuss avenues for further research. Papers published between 2011 and 2022 were analyzed for details about quantitative analysis approaches, methods of image annotation and choice of image processing software. It is shown that quantitative processing is becoming more common in episcopic microscopy and that manual annotation is the predominant method of image analysis. Our meta-analysis highlights where tools and methods require further development in this field, and we discuss what this means for the future of quantitative episcopic imaging, as well as how annotation and quantification may be automated and standardized across the field.

Hypertension is a chronic non-communicable disease which is one of the main causes of serious cardiovascular disease death in the community. The level of treatment and health control for hypertensive patients is still not optimal due to lack of information. Aim was to identify various current methods of health education by nurses and their impact on hypertensive patients. Method Literature review research. The literature was obtained from the Scopus, Sage and PubMed databases with the keywords "Intervention" OR "Methods" AND "Nursing" AND "Hypertension". There are seven literatures that are determined to meet the requirements of the inclusion criteria. Results found three types of health education methods performed by nurses: 1) direct health education methods; nurses meet and meet face to face with patients in the form of individual teaching or training, 2) indirect health education methods; nurses are not face-to-face but use telephone or mobile communication aids to convey information and send SMS about health, and use internet-based websites to convey health information, 3) combined health education methods; nurses face to face with patients and follow-up care is carried out by indirect health education methods. The impact of health education methods carried out by nurses on hypertensive patients is that the level of patient adherence increases in treatment, increased knowledge levels, better blood pressure control, healthy lifestyle practices, adherence to diet, improved quality of life, and positive nurse-patient feedback occurs. in fulfilling mutually agreed upon treatment appointments. Conclusion health education methods carried out by nurses have a very positive impact on disease management and prevention of risk factors for complications in hypertensive patients.

E-commerce has gained increased popularity over the last decade. To date, there is an open debate as to whether e-commerce or brick-and-mortar shopping is environmentally less sustainable, especially due to the growing mobility resources needed for e-commerce distribution. The analysis at hand compares the CO2-equivalent emissions of e-commerce and brick-and-mortar shopping of pharmaceutical products considering spatial aspects and the typical transport modal mix of consumers when doing online and offline shopping. The object of analysis is a retailer of pharmaceutical products, more precisely medicines, which offers, both, brick-and-mortar shop and online shopping possibilities. The results show that spatial aspects concerning the residential location of consumers, the vehicles used for shopping trips, the shopping basked size, and trip-chaining effects have a crucial impact on the mobility demand and CO2-equivalent emissions of the two commerce forms. In general, for rural and sub-urban areas, e-commerce results in lower CO2-equivalent emissions, while in urban areas, brick-and-mortar shopping is the favourable solution, if the consumers walk or cycle to the next pharmacy.

Conclusion: When applied to the air-abraded Filtek™ Bulk Fill Flowable Restorative composite surface, 10-MDP-containing adhesives perform better than 10-MDP-free adhesives. The binding strength was unaffected by the 10-MDP-containing adhesives' chemical makeup. The bond strength endurance of adhesives containing 10-MDP decreases with age. Keywords: keyword 1; keyword 2; keywords: low-viscosity bulk fill composite, universal adhesives, self-etch adhesive, 10-MDP, aging, bond strength.