ARTICLE
|
doi:10.20944/preprints202401.2178.v1
Subject:
Medicine And Pharmacology,
Epidemiology And Infectious Diseases
Keywords:
Flouroquinolone resistance; Docking analysis; Antimicrobial resistance; Salmonella typhi; Mutation analysis
Online: 1 February 2024 (02:09:55 CET)
REVIEW
|
doi:10.20944/preprints202401.2065.v1
Subject:
Medicine And Pharmacology,
Endocrinology And Metabolism
Keywords:
Thyroid cancer; fine needle aspiration; thyroid nodule; molecular cytology; genetic analysis; mutation
Online: 30 January 2024 (04:57:53 CET)
ARTICLE
|
doi:10.20944/preprints202312.1727.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
amyotrophic lateral sclerosis; ATXN2, risk factor; frontotemporal dementia; mutation; poli-Q expansion
Online: 22 December 2023 (12:28:30 CET)
ARTICLE
|
doi:10.20944/preprints202310.0672.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
bright yellow mosaic; coat protein; mutation; PepMV strains; symptom induction; virus evolution
Online: 11 October 2023 (09:17:05 CEST)
ARTICLE
|
doi:10.20944/preprints202309.1034.v1
Subject:
Medicine And Pharmacology,
Pathology And Pathobiology
Keywords:
papillary thyroid carcinoma; BRAF-like; RAS-like; BRAFV600E; RAS mutation; prediction model
Online: 15 September 2023 (10:54:29 CEST)
REVIEW
|
doi:10.20944/preprints202305.1547.v1
Subject:
Biology And Life Sciences,
Neuroscience And Neurology
Keywords:
Amyloid; Aggregation; Self-assembly; Gene mutation; Disease Pathogenesis; Inborn errors of metabolism
Online: 23 May 2023 (03:35:10 CEST)
HYPOTHESIS
|
doi:10.20944/preprints202303.0476.v2
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
Alzheimer's Disease; Familial Alzheimer Disease (FAD); presenilins; Amyloid beta Precursor Protein; mutation
Online: 23 April 2023 (02:50:35 CEST)
COMMUNICATION
|
doi:10.20944/preprints202106.0238.v1
Subject:
Biology And Life Sciences,
Anatomy And Physiology
Keywords:
Immunoinformatics; Molecular dynamics simulation; mutation; SARS-CoV-2; Spike protein; Virus structure
Online: 8 June 2021 (13:57:03 CEST)
ARTICLE
|
doi:10.20944/preprints202008.0621.v2
Subject:
Biology And Life Sciences,
Anatomy And Physiology
Keywords:
Clustering; Mutation; Amino acid substitution; Structural proteins; Biochemical properties; Functional sub-domains
Online: 4 March 2021 (10:17:15 CET)
ARTICLE
|
doi:10.20944/preprints202010.0239.v1
Subject:
Physical Sciences,
Acoustics
Keywords:
KRas-4B; mutation; post-translational modification; HVR; anionic plasma membrane; signaling; cholesterol
Online: 12 October 2020 (12:31:28 CEST)
REVIEW
|
doi:10.20944/preprints202009.0395.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
Spike protein, V483A, substitution mutation, virus-host cell interaction, high transmission, infectivity.
Online: 17 September 2020 (10:43:02 CEST)
ARTICLE
|
doi:10.20944/preprints202007.0132.v1
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
coronavirus; spike protein; database; sequence alignment; mutation; homology model; hydrophobic amino acids
Online: 7 July 2020 (16:49:04 CEST)
HYPOTHESIS
|
doi:10.20944/preprints202004.0286.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
SARS-CoV-2; domain-fold; evolutionary fingerprint; conserved domain; point mutation; recombination
Online: 16 April 2020 (16:13:13 CEST)
ARTICLE
|
doi:10.20944/preprints202001.0130.v1
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
PD-1; PD-L1; Cancer-linked genetic mutation; Electrostatic repulsion; Structural evolution
Online: 12 January 2020 (16:58:35 CET)
ARTICLE
|
doi:10.20944/preprints201807.0154.v1
Subject:
Biology And Life Sciences,
Plant Sciences
Keywords:
bread wheat; correlations, gamma, grain nutrients concentrations; mutation, phytic acid; metals bioavailability
Online: 9 July 2018 (15:39:51 CEST)
ARTICLE
|
doi:10.20944/preprints202406.2061.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
premature termination codon; nonsense mutation; Nonsense-mediated decay; translational readthrough inducing drugs; oxadiazoles.
Online: 29 June 2024 (00:09:00 CEST)
REVIEW
|
doi:10.20944/preprints202406.0046.v1
Subject:
Medicine And Pharmacology,
Obstetrics And Gynaecology
Keywords:
in vitro activation of dormant follicles; primary ovarian insufficiency; therapeutic mechanism; gene mutation
Online: 3 June 2024 (08:22:13 CEST)
ARTICLE
|
doi:10.20944/preprints202403.1825.v1
Subject:
Medicine And Pharmacology,
Other
Keywords:
hyperinsulinemic hypoglycemia; ABCC8 gene; mutation; ATP- sensitive potassium channel; genetic heterogeneity; phenotypic variability
Online: 29 March 2024 (08:08:35 CET)
COMMUNICATION
|
doi:10.20944/preprints202401.0573.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
SARS-CoV-2; BA.2.86; Omicron; Subvariant; Mutation; Immune escape; Vaccine; Outbreak; Surveillance
Online: 8 January 2024 (07:06:28 CET)
CASE REPORT
|
doi:10.20944/preprints202307.2129.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
brain metastases; NSCLC; predictive biomarkers for radiotherapy; radiotherapy; prognostic scores; WBRT; BRAF mutation
Online: 31 July 2023 (11:49:37 CEST)
CASE REPORT
|
doi:10.20944/preprints202306.1051.v1
Subject:
Medicine And Pharmacology,
Ophthalmology
Keywords:
Clinical exome sequencing, C282Y mutation, Hereditary hemochromatosis, HFE gene, Iron overload, Pseudovitelliform maculopathy
Online: 14 June 2023 (13:47:40 CEST)
CASE REPORT
|
doi:10.20944/preprints202306.0535.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
brain metastases; NSCLC; predictive biomarkers for radiotherapy; radiotherapy; prognostic scores; WBRT; BRAF mutation
Online: 7 June 2023 (10:37:52 CEST)
ARTICLE
|
doi:10.20944/preprints202305.0072.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
APOBEC3A; carcinogenesis; DNA deamination; DNA mutation, hepatocellular carcinoma; molecular mechanism; RNA editing; tumorigenesis
Online: 2 May 2023 (08:12:34 CEST)
REVIEW
|
doi:10.20944/preprints202212.0300.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
medulloblastoma; TP53 mutation; molecular classification; diagnostics; liquid biopsy; animal models; transcriptome; precision oncology
Online: 16 December 2022 (08:47:35 CET)
ARTICLE
|
doi:10.20944/preprints202202.0243.v1
Subject:
Medicine And Pharmacology,
Cardiac And Cardiovascular Systems
Keywords:
left ventricular noncompaction; cardiomyopathy; sinus bradycardia; HCN4 mutation; late gado-linium enhancement; children
Online: 21 February 2022 (03:16:22 CET)
REVIEW
|
doi:10.20944/preprints202105.0166.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
DNA sequence-encoded nucleosome ordering; Nucleosome depleted regions; DNS sequence mutation; Chromatin evolution.
Online: 10 May 2021 (10:50:00 CEST)
ARTICLE
|
doi:10.20944/preprints202102.0503.v1
Subject:
Computer Science And Mathematics,
Algebra And Number Theory
Keywords:
Machine Learning; Software Testing; Quality Attributes; Deep Learning; Model Mutation testing; DNN; DL
Online: 23 February 2021 (09:22:02 CET)
ARTICLE
Subject:
Medicine And Pharmacology,
Urology And Nephrology
Keywords:
Immune cell; DNA CpGs; Bladder cancer; Subtype; mutation; CNV; Immune score; Immune Checkpoints
Online: 5 September 2020 (06:00:06 CEST)
CASE REPORT
|
doi:10.20944/preprints202008.0198.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
SARS-CoV-2; coinfection; diabetes, bloodstream infection; Candida glabrata; echinocandin resistance; FKS mutation
Online: 7 August 2020 (12:54:12 CEST)
ARTICLE
|
doi:10.20944/preprints202005.0463.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
comparative genomics; SARS-CoV-2; microevolution; quasi-species; point mutation; disinfectants as mutagens
Online: 28 May 2020 (16:21:05 CEST)
REVIEW
|
doi:10.20944/preprints202403.0990.v1
Subject:
Biology And Life Sciences,
Ecology, Evolution, Behavior And Systematics
Keywords:
Non-adaptive radiation, mutation rates, species richness, species evenness, karyotype diversity, DNA repair systems
Online: 18 March 2024 (10:47:25 CET)
ARTICLE
|
doi:10.20944/preprints202309.1877.v1
Subject:
Medicine And Pharmacology,
Ophthalmology
Keywords:
rod-cone dystrophy; retinitis pigmentosa; RP1 gene; founder effect; inherited retinal dystrophies; founder mutation
Online: 27 September 2023 (11:06:58 CEST)
ARTICLE
|
doi:10.20944/preprints202304.0601.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
FTSJ1; methyltransferase; tRNA; readthrough; stop codon mutation; small molecules; docking; molecular dynamics; MM-GBSA
Online: 20 April 2023 (03:21:07 CEST)
ARTICLE
|
doi:10.20944/preprints202208.0355.v1
Subject:
Medicine And Pharmacology,
Psychiatry And Mental Health
Keywords:
developmental delay; de novo mutation; protein-protein interaction; PPI interface; protein in-teractome; PsymuKB
Online: 19 August 2022 (04:50:42 CEST)
REVIEW
|
doi:10.20944/preprints202207.0250.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
Emergence of Omicron and its mechanism; mutation and sub-lineages; Monoclonal antibodies; Antiviral drugs
Online: 18 July 2022 (07:48:00 CEST)
ARTICLE
|
doi:10.20944/preprints202203.0246.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
entrenchment; protein stability; TEM-1 beta-lactamase; CTX-M-15 beta-lactamase; M182T mutation
Online: 17 March 2022 (08:43:11 CET)
ARTICLE
|
doi:10.20944/preprints202111.0004.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
m1A; Tumor microenvironment; PD-1/PD-L1; CTLA-4; Tumor Mutation Burden; Bioinformatics Analysis
Online: 1 November 2021 (10:39:51 CET)
ARTICLE
|
doi:10.20944/preprints202006.0032.v1
Subject:
Medicine And Pharmacology,
Pathology And Pathobiology
Keywords:
SARS-CoV-2; Spike protein; COVID-19; Mutation; hACE2 Receptor; Real-time PCR; Vaccine
Online: 4 June 2020 (08:48:03 CEST)
REVIEW
|
doi:10.20944/preprints201905.0130.v1
Subject:
Biology And Life Sciences,
Plant Sciences
Keywords:
induced mutagenesis; fast neutron irradiation; mutation mapping; deletagene; next-generation sequencing technologies; reverse genetics
Online: 10 May 2019 (14:38:21 CEST)
ARTICLE
|
doi:10.20944/preprints202407.1610.v1
Subject:
Biology And Life Sciences,
Animal Science, Veterinary Science And Zoology
Keywords:
electroporation; gene editing; CRISPR/Cas9; sheep zygotes; mutation efficiency; homologous recombination; in vitro fertilization (IVF)
Online: 19 July 2024 (12:07:12 CEST)
ARTICLE
|
doi:10.20944/preprints202407.0591.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
COVID-19; haplotypes; nucleocapsid protein; mutation; pandemic; protein structure; recruitment; variant of concern; virus evolution
Online: 8 July 2024 (08:35:41 CEST)
REVIEW
|
doi:10.20944/preprints202306.1921.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Antibiotic resistance; Drug designing; Bacterial mutation; Bacterial evolution; Horizontal gene transfer; Public and agricultural health
Online: 27 June 2023 (13:55:21 CEST)
REVIEW
|
doi:10.20944/preprints202211.0140.v1
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
Diffuse Intrinsic PontineDiffuse Intrinsic Pontine Glioma; DIPG; pediatric tumors; cancer; CAR-T; pons; histone mutation
Online: 8 November 2022 (02:57:43 CET)
REVIEW
|
doi:10.20944/preprints202202.0224.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
COVID-19; pandemic; SARS-CoV-2; Omicron variant; emerging disease; global health; virus; genome; mutation
Online: 18 February 2022 (05:23:18 CET)
ARTICLE
|
doi:10.20944/preprints202112.0192.v1
Subject:
Engineering,
Industrial And Manufacturing Engineering
Keywords:
End-point phosphorus content; Deep extreme learning machine; Sparrow search algorithm; Trigonometric substitution; Cauchy mutation
Online: 10 December 2021 (15:04:59 CET)
REVIEW
|
doi:10.20944/preprints201912.0131.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
single nucleotide polymorphism; docking; molecular dynamics; in-silico studies; protein dynamics; missense; prediction algorithm; mutation
Online: 10 December 2019 (07:56:43 CET)
ARTICLE
|
doi:10.20944/preprints201812.0205.v1
Subject:
Biology And Life Sciences,
Ecology, Evolution, Behavior And Systematics
Keywords:
Diminished fitness return, mutation rate tuning, Darwinian evolution; neutral evolution; punctuated equilibrium; unified evolutionary theory
Online: 17 December 2018 (16:10:52 CET)
ARTICLE
|
doi:10.20944/preprints202403.0562.v1
Subject:
Medicine And Pharmacology,
Epidemiology And Infectious Diseases
Keywords:
Omicron JN.1; SARS-CoV-2; Sanger sequencing; RBD; L455S mutation; immune evasion; vaccination policies; CDC
Online: 11 March 2024 (09:02:03 CET)
ARTICLE
|
doi:10.20944/preprints202311.1760.v1
Subject:
Engineering,
Electrical And Electronic Engineering
Keywords:
Ultralight power generation system; Load power mutation; Exquisite control strategy; Mismatching degree; High-quality electrical energy
Online: 28 November 2023 (10:30:40 CET)
REVIEW
|
doi:10.20944/preprints202104.0602.v3
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
carcinogenesis; cancer treatment; cervical cancer; DNA synthesis; free-radical; retinoblastoma; ribonucleotide reductase; somatic mutation theory (SMT)
Online: 28 December 2021 (10:53:54 CET)
REVIEW
|
doi:10.20944/preprints202010.0514.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
Single-Nucleotide Polymorphisms; Point Mutation; Chemokines; T-cells; Viral Infection; Tumorigenesis; T-cell Surface; Immune Response
Online: 26 October 2020 (11:08:40 CET)
ARTICLE
|
doi:10.20944/preprints202408.1713.v1
Subject:
Biology And Life Sciences,
Biophysics
Keywords:
Inter-molecular Binding Affinity; Synthetic Data Augmentation; Computational Biomolecule Design and Discovery; Site-specific mutation; Structural biophysics
Online: 23 August 2024 (10:10:20 CEST)
REVIEW
|
doi:10.20944/preprints202408.0744.v1
Subject:
Medicine And Pharmacology,
Hematology
Keywords:
Peripheral T-cell lymphoma; Histone deacetylase (HDAC); HDAC inhibitor (HDACi); targeted therapy; epigenetic; DNA mutation; TET2; DNMT3A
Online: 12 August 2024 (05:07:04 CEST)
BRIEF REPORT
|
doi:10.20944/preprints202008.0148.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
Alignment-free software tool; Coronavirus; COVID-19; D614G mutation; Sarbecovirus; SARS-CoV; SARS-CoV-2; Spike glycoprotein
Online: 6 August 2020 (10:12:00 CEST)
ARTICLE
|
doi:10.20944/preprints202405.0417.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
non-melanoma skin cancer; cutaneous squamous cell carcinoma (cSCC); recurrent cSCC; next generation sequencing (NGS); mutation profile; immunogenicity
Online: 8 May 2024 (09:17:25 CEST)
ARTICLE
|
doi:10.20944/preprints202005.0407.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
SARS-CoV-2; spike protein; D614G mutation; genotype distribution; furin cleavage site; secondary structure; sequence analysis; homology modeling
Online: 24 May 2020 (20:31:16 CEST)
ARTICLE
|
doi:10.20944/preprints202404.0092.v3
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
p53 loss; KRAS mutation; SLC7A11; SLC38A5; ferroptosis; macropinocytosis; antioxidant machinery; lipid peroxidation; niclosamide; colon cancer
Online: 7 June 2024 (02:47:47 CEST)
REVIEW
|
doi:10.20944/preprints202403.0456.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
antiestrogen; cancer therapy; estrogen; DNA damage; DNA damage response; DNA repair; endocrine disruptor; estrogen receptor; growth factor receptor; mutation
Online: 7 March 2024 (14:19:55 CET)
REVIEW
|
doi:10.20944/preprints202407.1905.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
antiestrogen; breast cancer, cancer therapy; DNA damage; DNA repair; endocrine disruptor; estrogen receptor; growth factor receptor; immune reaction; mutation
Online: 24 July 2024 (13:09:11 CEST)
ARTICLE
|
doi:10.20944/preprints202307.1116.v1
Subject:
Public Health And Healthcare,
Public, Environmental And Occupational Health
Keywords:
environmental stressors; pharmaceuticals; antibiotic resistance; selection pressure; public health; tolerant bacteria; environmental pollution; mutation; whole genome sequencing; single nucleotide polymorphisms
Online: 18 July 2023 (05:36:57 CEST)
ARTICLE
|
doi:10.20944/preprints202401.1929.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
PitNETs; alternative splicing, TrkAIII splice variant; HIF2a, Splice factors SF3B1, U2AF and SRSF2, hotspot SF3B1 mutation, Xbp1, JCPyV large T antigen
Online: 26 January 2024 (15:15:02 CET)
HYPOTHESIS
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
incurable disease; chronic disease; cancer theory; central nervous system; state memory; mutation; tissue ecosystem; emotion; stress; exercise; baseline biochemical and cellular processes
Online: 24 November 2019 (14:50:49 CET)
REVIEW
|
doi:10.20944/preprints202403.0720.v1
Subject:
Medicine And Pharmacology,
Gastroenterology And Hepatology
Keywords:
early onset gastrointestinal malignancies; young adult cancer; early onset colorectal cancer; early onset esophageal cancer; esophageal adenocarcinoma; esophageal squamous cell carcinoma; early onset gastric cancer; early onset pancreatic cancer; early onset liver cancer; gastrointestinal malignancy; hepatocellular carcinoma; BRCA mutation; ATM mutation; MLH1; MSH2; MSH6; PRSS1; early onset biliary malignancy
Online: 12 March 2024 (14:33:15 CET)
REVIEW
|
doi:10.20944/preprints202406.0155.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
CAR-T cell therapy; Hematologic malignancies; Cytokine release syndrome; Antigen mutation; γ δ CAR-T cells; Multi-targeted CAR-T cells; Precision medicine
Online: 4 June 2024 (16:12:58 CEST)
REVIEW
|
doi:10.20944/preprints202111.0132.v2
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
adults; influenza; cell-cultured vaccine; egg-based vaccine; influenza vaccine; relative vaccine effectiveness; real word evidence; mutation; human / prevention & control*; comparative study
Online: 20 December 2021 (11:00:26 CET)
REVIEW
|
doi:10.20944/preprints201707.0074.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
cancer etiology; carcinogenesis; cancer prevention; stem cells; cancer stem cells; stem cell environment; cells of origin in cancer; somatic mutation theory of cancer
Online: 26 July 2017 (08:42:41 CEST)
ARTICLE
|
doi:10.20944/preprints202406.0009.v1
Subject:
Medicine And Pharmacology,
Pulmonary And Respiratory Medicine
Keywords:
EGFR mutation; osimertinib; acquired resistance; secondary mutations; novel drugs; non-small cell lung cancer; epithelial to mesenchymal transition; MET gene amplification; Ba/F3 cells
Online: 4 June 2024 (02:53:41 CEST)
REVIEW
|
doi:10.20944/preprints202304.0973.v1
Subject:
Biology And Life Sciences,
Neuroscience And Neurology
Keywords:
vitamin B1; vitamin B6; vitamin B3; pyridoxal-5’-phosphate; thiamine diphosphate; NAD+, mutation in vitamin-binding protein; Charcot-Marie-Tooth disease; DHTKD1; PDK3; PDXK
Online: 26 April 2023 (08:33:26 CEST)
ARTICLE
|
doi:10.20944/preprints202205.0280.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
purine-rich element binding protein A gene; PURA; MIM: 600473; transcriptional activator protein Pur-alpha; cognitive developmental delay; mental retardation; Mutation c.697_699del p.Phe233del
Online: 20 May 2022 (16:58:04 CEST)
REVIEW
|
doi:10.20944/preprints202010.0510.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
disease-associated mutation; IDR; intrinsically disordered region; LLPS; phase separation; PTM; Ahr; AhRR; SIM1; SIM2; Hif-2α; NPAS4; ARNT2; BMAL1; disorder prediction; LLPS prediction; cancer; HuVarBase; catGranule prediction
Online: 26 October 2020 (10:30:47 CET)
REVIEW
|
doi:10.20944/preprints202401.2238.v1
Subject:
Biology And Life Sciences,
Other
Keywords:
N-glycosylation; disease; conformational mutant; aberrant protein assembly; energy landscape; SARS-CoV-2 spike protein; glucose regulated protein 94 (GRP94); prion protein; disease-associated protein conformation; protein dynamics; protein assembly mutation; gain-of-function conformational change
Online: 31 January 2024 (14:12:55 CET)