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Working Paper CASE REPORT

SARS-CoV-2 Infection in the Central Nervous System of a 1-Year-Old Infant

Ismael Carlos Gomes, Karina Karmirian, Julia Oliveira, Carolina Pedrosa, Mayara Abud Mendes, Fernando Colonna Rosman, Leila Chimelli, Stevens Rehen

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: SARS-CoV-2 neuroinvasion; COVID-19; infant; Choroid plexus

Online: 15 March 2021 (13:03:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0477.v1

Discovery of Eriodictyol as Putative Exportin-1 Inhibitor for Non-small Cell Lung Cancer Therapy

Temidayo Olamide Adigun, Ireoluwa Yinka Joel, Olukayode Olusola Bankole, George Oche Ambrose, Oluwatobi Ayodeji Medayedupin, Oluwatobi Cynthia Omoyeni, Adebimpe Ayomide Agunlejika, Ugochukwu Okechukwu Ozojiofor, Adedayo Pius Omoniyi, Idowu Yetunde Fakolujo

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Exportin-1; Eriodictyol; Juglans mandshurica; Non-small cell lung cancer

Online: 23 October 2020 (10:19:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0185.v1

Lactobacillus Rhamnosus GR-1 Ameliorates Trueperella Pyogenes–Induced Barrier Dysfunction of Bovine Endometrial Epithelial Cells

Ning Liu, Xuan Wu, Mengling Wang, Yanan Li, Le Xu, Yaohong Zhu

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Trueperella pyogenes; bovine endometrial epithelial cells; inflammasome; tight junction; apoptosis; Lactobacillus rhamnosus GR-1

Online: 8 October 2020 (22:07:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202009.0693.v1

Reading between the Genetic Lines: How Epigenetics is Unlocking Novel Therapies for Type 1 Diabetes

Ammira Akil, Laila Ali, Esraa Yassin, Khalid A. Fakhro, Sujitha Jeya, Alya Al-Kurbi

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: chromatin; DNA methylation; epigenetics; histone modifications; metaboloepigenetics; miRNA; therapy; type 1 diabetes

Online: 28 September 2020 (17:48:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0470.v1

Single Nucleotide Polymorphisms of Indoleamine 2,3-Dioxygenase 1 Influenced the Age Onset of Parkinson’s Disease

Nóra Török, Rita Maszlag-Török, Kinga Molnár, Zoltán Szolnoki, Ferenc Somogyvári, Krisztina Boda, Masaru Tanaka, Péter Klivényi, László Vécsei

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: kynurenines; tryptophan; indoleamine 2,3-dioxygenase; single nucleotide polymorphisms; Parkinson’s diseases; neurodegenerative diseases

Online: 20 September 2020 (14:27:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0043.v1

Displacements Monitoring over Czechia by IT4S1 System for Automatised Interferometric Measurements Using Sentinel-1 Data

Milan Lazecky, Emma Hatton, Pablo J. Gonzalez, Ivana Hlavacova, Eva Jirankova, Frantisek Dvorak, Zdenek Sustr, Jan Martinovic

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: Displacement measurement; High performance computing; Radar interferometry; Synthetic aperture radar

Online: 2 August 2020 (15:57:56 CEST)

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Sentinel-1 satellite system continuously observes European countries in a relatively high revisit frequency of 6 days per orbital track. Given the Sentinel-1 configuration, most areas in Czechia are observed every 1–2 days by different tracks in a moderate resolution. This is attractive for various types of analyses by various research groups. The starting point for processing is an original data provided by ESA, for interferometry (InSAR) this level is a Single Look Complex (SLC) data. This work represents advantages of storing data augmented to a specifically corrected level of data, SLC-C. The presented database contains Czech nation-wide Sentinel-1 data stored in burst units that have been preprocessed to the state of a consistent well-coregistered dataset of SLC-C. These are resampled SLC data with their phase values reduced by a topographic phase signature, ready for fast interferometric analyses (an interferogram is generated by a complex conjugate between two stored SLC-C files). The data can be used directly into multitemporal interferometry techniques, e.g. Persistent Scatterers (PS) or Small Baseline (SB) techniques applied here. A further development of the nation-wide system utilising SLC-C data would lead into a dynamic state where every new pre-processed burst triggers a processing update to detect unexpected changes from InSAR time series and therefore provide a signal for early warning against a potential dangerous displacement, e.g. a landslide, instability of an engineering structure or a formation of a sinkhole. An update of the processing chain would also allow use of cross-polarised Sentinel-1 data, needed for polarimetric analyses. The current system is running at a national supercomputing centre IT4Innovations in interconnection to the Czech Copernicus Collaborative Ground Segment (CESNET), providing fast on-demand InSAR results over Czech territories. A full nation-wide PS processing using data over Czechia has been performed in 2017, discovering several areas of land deformation. Its downsampled version and basic findings are demonstrated within the article.

Preprint ARTICLE | doi:10.20944/preprints202005.0432.v1

Selenium-Dependent Readthrough of the Conserved 3’-Terminal UGA Stop Codon of HIV-1 Nef

Lakmini Premadasa, Gabrielle Dailey, Jan Ruzicka, Ethan Taylor

Subject: Biology And Life Sciences, Food Science And Technology Keywords: antisense; HIV-1 nef; stop codon readthrough; selenium; thioredoxin reductase

Online: 26 May 2020 (13:16:09 CEST)

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Working Paper ARTICLE

Public Health Intervention Framework for Reviving Economy Amid the COVID-19 Pandemic (1): A Concept

Jianqing Wu, Zha Ping

Subject: Business, Economics And Management, Business And Management Keywords: coronavirus; COVID-19; public health intervention; revive economy; disease severity; transmission route; influenza; ventilation; work environment

Online: 16 April 2020 (12:34:43 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202004.0180.v1

Hypothesis: mPGES-1-Derived Prostaglandin E2, a So Far Missing Link in COVID-19 Pathophysiology?

Jan Smeitink, Xiaolan Jiang, Svetlana Pecheritsyna, Herma Renkema, Rob van Maanen, Julien Beyrath

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: COVID-19; prostaglandins; mPGES1 inhibitor; ARDS; sonlicromanol; KH176

Online: 12 April 2020 (04:36:48 CEST)

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Working Paper COMMUNICATION

Serial Femtosecond X-ray Diffraction of HIV-1 Gag MA-IP6 Microcrystals at Ambient Temperature

Halil I Ciftci, Raymond G Sierra, Chun Hong Yoon, Zhen Su, Hiroshi Tateishi, Ryoko Koga, Koiwai Kotaro, Fumiaki Yumoto, Toshiya Senda, Mengling Liang, Soichi Wakatsuki, Masami Otsuka, Mikako Fujita, Hasan DeMirci

Subject: Biology And Life Sciences, Virology Keywords: serial femtosecond X-ray crystallography; human immunodeficiency virus; matrix protein; inositol hexaphosphate; ambient temperature

Online: 25 March 2019 (11:56:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0381.v1

Ethyl 4-(2-fluorophenyl)-6-methyl-2-thioxo-1-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Itamar Luís Gonçalves, Luciano Porto Kagami, Gustavo Machado das Neves, Liliana Rockenbach, Leonardo Davi, Alceu Felipe Soares, Solange Cristina Garcia, Vera Lucia Eifler-Lima

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Biginelli reaction; dihydropyrimidin-2-thiones; synthesis, virtual screening, drug design; LaSOM 282

Online: 17 October 2018 (09:34:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0527.v1

GLP-1 Analogue Liraglutide Attenuates Mutant Huntingtin-Induced Neurotoxicity by Restoration of Neuronal Insulin Signaling

Ching-Chi Chang, Tzu-Chin Lin, Hsiao-Li Ho, Chien-Yin Kuo, Hsin-Hua Li, Tatiana A. Korolenko, Wei-Jen Chen, Te-Jen Lai, Ying-Jui Ho, Chih-Li Lin

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: autophagy; huntingtin; insulin signaling; liraglutide; oxidative stress

Online: 27 July 2018 (03:35:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0169.v1

Explicit Formula for Average Run Length of Double Moving Control Chart for INAR(1) Processes

Sukanya Phant, Saowanit Sukparungsee, Yupaporn Areepong

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: average run length; double moving average control chart; Poisson count process

Online: 18 August 2016 (07:27:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1102.v1

Relationship Between Perception of Quality of Life and Nutri-tional Status of Mothers Caring For Childrew With Type 1 Diabetes Mellitus

Maria de Nazareth de Lima Carneiro, Arthur Andrade da Fonseca, Rachel Coelho Ripardo, Layla Sandia Cezário Alves, Manuela Maria de lima Carvalhal, Daniela Lopes Gomes

Subject: Public Health And Healthcare, Other Keywords: Quality of life; Health of caregivers; Nutritional status; type 1 diabetes

Online: 17 April 2024 (15:04:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints202402.1417.v1

Harnessing the Synergy of SGLT2 Inhibitors and Continuous Ketone Monitoring (CKM) in Managing Heart Failure Among Patients with Type 1 Diabetes

Nicola Tecce, Giorgio De Alteriis, Giulia de Alteriis, Ludovica Verde, Mario Felice Tecce, Annamaria Colao, Giovanna Muscogiuri

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: heart failure; type 1 diabetes; diabetic cardiomyopathy; hospitalization; HFpEF; HFrEF; SGLT2-i; sodium-glucose cotransporter-2 inhibitors; diabetic ketoacidosis; epidemiologic studies; patient education; continuous monitoring of ketone levels; ketonemia

Online: 26 February 2024 (11:54:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1317.v1

Gas Temperature Distribution in the Combustion Chamber of a GTM400 Mod Turbojet Engine Powered by Jet A-1 Fuel and Hydrogen

Łukasz Brodzik

Subject: Physical Sciences, Thermodynamics Keywords: turbojet engine; hydrogen combustion process; combustion chamber

Online: 18 January 2024 (03:29:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.2109.v1

Theoretical Study on the Structures and Stabilities of CunZn3O3 (N = 1 – 4) Clusters: Sequential Doping of Zn3O3 Cluster with Cu Atoms

Zhi-Wei Tao, Han-Yi Zou, Hong-Hui Li, Bin Wang, Wen-Jie Chen

Subject: Chemistry And Materials Science, Theoretical Chemistry Keywords: Copper-doped zinc oxide clusters; Density functional theory; Structural evolution; Reactivity

Online: 27 December 2023 (11:52:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202304.1028.v1

Evaluation of DNA Methylation Profiles of LINE-1, Alu and Ribosomal DNA Repeats in Human Cell Lines Exposed to Radiofrequency Radiation

Francesco Ravaioli, Maria Giulia Bacalini, Cristina Giuliani, Camilla Pellegrini, Chiara D'Silva, Sara De Fanti, Chiara Pirazzini, Gianfranco Giorgi, Brunella Del Re

Subject: Biology And Life Sciences, Life Sciences Keywords: Radiofrequency electromagnetic field; DNA methylation; Neuroblastoma; LINE-1; Alu; ribosomal DNA

Online: 27 April 2023 (04:12:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0128.v1

Epidemiological Description and Molecular Characterization of Intrafamily Transmission of Human T-Lymphotropic Virus Type 1 in an Endemic Region of Brazil

Cássia Pereira, Samir Mansour Moraes Casseb, Akim F.S. Nobre, Maria N. L. Reis, Carlos A. Costa, Louise S. C. Covre, Maisa S. Sousa

Subject: Biology And Life Sciences, Virology Keywords: HTLV; Amazon; Phylogeny

Online: 7 February 2023 (10:47:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0322.v1

Transporter Associated with Antigen Processing 1 (TAP1) as a Potential Biomarker for Breast, Lung, Liver and Ovarian Cancer using Health Informatics

Anika Tabassum, Md. Nazmus Samdani, Tarak Chandra Dhali, Rahat Alam, Foysal Ahammad, Abdus Samad, Tomasz M. Karpiński

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: TAP1; transcriptional expression; methylation analysis; survival analysis; co-expression; pathway analysis; health informatics

Online: 14 August 2020 (11:17:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0048.v1

Vitamin D and ω-3 Supplementations in Mediterranean Diet During the 1st Year of Overt Type 1 Diabetes: A Cohort Study

Francesco Cadario, Erica Pozzi, Stefano Rizzollo, Marta Stracuzzi, Sheila Beux, Alberto Giorgis, Deborah Carrera, Fabiola Fullin, Sergio Riso, Angela Maria Rizzo, Gigliola Montorfano, Marco Bagnati, Umberto Dianzani, Philippe Caimmi, Gianni Bona, Camillo Ricordi

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: cholecalciferol; omega3; EPA; DHA; arachidonic acid; AA/EPA ratio; type 1 diabetes; remission period; honeymoon period

Online: 3 July 2019 (08:10:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201902.0211.v1

Microscopic Views of Atomic and Molecular Oxygen Bonding with epi Ge(001)-2×1 Studied by High-Resolution Synchrotron Radiation Photoemission

Yi-Ting Cheng, Hsien-Wen Wan, Chiu-Ping Cheng, Jueinai Kwo, Minghwei Hong, Tun-Wen Pi

Subject: Physical Sciences, Applied Physics Keywords: Ge(001)-2×1; oxidation; synchrotron radiation photoemission

Online: 22 February 2019 (04:07:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0334.v1

Identification of Novel Inhibitors of Pteridine Reductase 1 in Trypanosoma brucei via Computational Structure-Based Approaches and In Vitro Inhibition Assays

Magambo Phillip Kimuda, Dustin Laming, Heinrich C. Hoppe, Özlem Tastan Bishop

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: human African trypanosomiasis; pteridine reductase 1; PTR1; DHFR; antifolates; anti-trypanosomal agents; molecular dynamics; dynamic residue network analysis; binding free energy; isobologram assay

Online: 14 November 2018 (10:39:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.2076.v1

Susceptibility of Foodborne Pathogens to Milk-Origin Lactic Acid Bacteria Supernatants: A Comprehensive Meta-Regression Study

Nathália Fernandes, Yara Loforte, Vasco Cadavez, Ursula Gonzales-Barron

Subject: Biology And Life Sciences, Food Science And Technology Keywords: antimicrobial peptides; hurdle technology; cheese; bacteriocinogenic

Online: 28 June 2024 (16:39:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0208.v1

Can Boric Acid-Based Bait Materials Be Used as Attractants for Red Ant, Dorylus orientalis Westwood?

Elangbam Bidyarani Devi, Badal Bhattacharyya, K. Sindhura Bhairavi, Shimantini Borkataki, Sanjay Hazarika

Subject: Biology And Life Sciences, Insect Science Keywords: red ant; Dorylus orientalis; boric acid; bait materials; attractant; potato; Y-tube olfactometer

Online: 5 March 2024 (10:58:09 CET)

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Four groups (sugar, lipid, protein and waste based) of bait materials combined with boric acid were evaluated in laboratory and field conditions. When compared to all the sugar-based bait materials, a mixture of honey with boric acid registered to be the most effective in attracting the maximum number (83.00) of red ants followed by a mixture of molasses with boric acid (55.00). Likewise, among the oils tested, the highest number (47.33) of red ants registered was in the mixture of rice bran oil with boric acid followed by mustard oil with boric acid mixture (37.00). Similarly, from the protein-based bait materials, the maximum number of red ants (35.00) attraction was found in the mixture of gram flour with boric acid which was followed by dog biscuits with boric acid mixture (27.67). When all the waste-based bait materials were tested, sugarcane trash with boric acid mixture attracted most of the red ants (96.67) followed by banana peel with boric acid mixture (36.67). Based on the laboratory performance, the two best bait materials in each group were assessed against red ant, Dorylus orientalis in potato crops. Of the 8 bait materials tested, the use of rice bran oil with boric acid was found to be more attractive against red ants (1564.66, 1972.33 and 2636.33 during tuber formation, tuber maturity and harvesting stages, respectively) in potato crop when compared to other bait materials. Additionally, the attraction of D. orientalis was tested separately against rice bran oil, boric acid and rice bran oil in combination with boric acid using Y-tube olfactometer under laboratory conditions. Results indicated that rice bran oil in combination with boric acid had the highest attractiveness ratio of 86.66 per cent followed by boric acid and rice bran at 76.66 and 73.33 per cent, respectively. The outcome of the current investigation can be explored for the management of red ant menace in potato and other field crops, particularly grown under organic cultivation approach.

Preprint ARTICLE | doi:10.20944/preprints202312.0818.v1

Involvement of Abscisic Acid in Transition of Pisum sativum L. from Germination to Post-germination Stage

Galina Smolikova, Ekaterina Krylova, Ivan Petřík, Polina Vilis, Aleksander Vikhorev, Ksenia Strygina, Miroslav Strnad, Andrej Frolov, Elena Khlestkina, Sergei Medvedev

Subject: Biology And Life Sciences, Plant Sciences Keywords: abscisic acid, DNA methylation, embryonic axes, ABA-associated genes, Pisum sativum L., seed-to-seedling transition

Online: 12 December 2023 (11:09:39 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202310.0537.v1

Comparison of Ceria-Supported Catalysts for Attaining NO - NO2 Equilibrium at Industrial Nitric Acid Plant Conditions

Jithin Gopakumar, Albert Miró i Rovira, Bjørn Christian Enger, David Waller, Magnus Rønning

Subject: Engineering, Chemical Engineering Keywords: the ostwald process; nitric acid; fertilizer; nitric oxide; ruthenium; ceria; manganese; catalysis

Online: 10 October 2023 (03:41:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0069.v1

Hyaluronic Acid-Conjugated 17β-Estradiol Provide More Effectively to Alleviate Estropause-Induced Cognitive Deficits in Rats

Mu-Hsuan Chen, Hsiao-Chun Lin, Tzu Chao, Viola Szu-Yuan Lee, Chia-Lung Hou, Tsyr-Jiuan Wang, Jeng-Rung Chen

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Cognitive deficit; Alzheimer’s disease; Cholinergic septo-hippocampal innervation system; Dendritic spine; Hippocampus; Morris water maze

Online: 2 October 2023 (10:32:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1659.v1

Feasibility Assessment of Acid Gas Injection in Saline Aquifers: A Case Study of an Iranian Offshore

Marilena Cardu, Oveis Farzay, Ali Shakouri, Seyedyasin Jamali, Seyedkhashayar Jamali

Subject: Engineering, Civil Engineering Keywords: acid gas injection (AGI); saline aquifers; capillary pressure; reservoir characterization; caprock integrity; capillary pressure

Online: 25 July 2023 (07:39:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0133.v1

Tumor-Specific Targeting of Polymer Drug Delivery Systems with Recombinant Proteins Bound via Tris(Nitrilotriacetic Acid)

Michal Pechar, Vlastimil Král, Lucie Woldřichová, Ladislav Androvič, Eliška Hrdá, Robert Pola, Sára Pytlíková, Martin Studenovský, Libor Kostka, Vladimír Šubr, Tomáš Etrych, Olga Kočková, Jéssica Mariane Ferreira Mendes, Milan Fábry, Richard Laga

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Hydrophilic polymers; Thermo-responsive polymers; Polymer drug delivery system; Tumor-specific targeting; Recombinant proteins; Non-covalent attachment; Tris(nitrilotriacetic acid) ligation

Online: 4 July 2023 (08:01:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0429.v1

High Dietary Folic Acid Intake is Associated with Genomic instability in Peripheral Lymphocytes of Healthy Adults

Khadijah I. Alnabbat, Ali M. Fardous, Aiman Shahab, Andrew A. James, Manhel R. Bahri, Ahmad R. Heydari

Subject: Biology And Life Sciences, Food Science And Technology Keywords: folate; folic acid; excess; UMFA; lymphocyte; micronuclei; fortification; methylation

Online: 25 August 2022 (08:06:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0066.v1

pH-Sensitive Polyacrylic Acid-Gated Mesoporous Silica Nanocarrier Incorporated with Calcium Ions for Controlled Drug Release

Jungwon Kong, Sung Soo Park, Chang-Sik Ha

Subject: Chemistry And Materials Science, Biomaterials Keywords: Mesoporous silica; Polyacrylic acid; Calcium ion; 5-Fluorouracil; Drug delivery

Online: 2 August 2022 (12:15:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0258.v1

An Experimental Investigation of Air-Acetic Acid Solution Gas-Liquid Two Phase in a Bubble Column

Wenlong Zhang, Shanglei Ning, Haibo Jin, Guangxiang He, Lei Ma, Xiaoyan Guo, Rongyue Zhang

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: air-acetic acid system; gas holdup; differential pressure transmitter; ERT; optical fiber probe

Online: 8 November 2020 (14:50:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202005.0062.v1

Thermal Decomposition Behavior of 3D Printing Filaments Made of Wood-filled Polylactic Acid (PLA)/Starch Blend

Yufeng Sun, Danbee Lee, Yapeng Wang, Suiliang Li, Jilai Ying, Xinping Liu, Guangyin Xu, Jaegyoung Gwon, Qinglin Wu

Subject: Chemistry And Materials Science, Biomaterials Keywords: Wood-filled PLA; Thermal Decomposition; Starch; 3D printing

Online: 5 May 2020 (05:44:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0008.v1

Metal Removal from Acid Waters by an Endemic Microalga from the Atacama Desert for Water Recovery

Marcela Martínez, Yanett Leyton, Luis A. Cisternas, Carlos Riquelme

Subject: Engineering, Chemical Engineering Keywords: Muriellopsis sp.; bioremediation; metallic ions; acid waters; removal

Online: 1 August 2018 (08:37:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201705.0218.v1

Oleanolic Acid Induces p53 Dependent Apoptosis via the ERK/JNK/AKT Pathway in Cancer Cell Lines

Gyeong-Ji Kim, Hyeon-Ju Jo, Kang-Hyun Chung, Kwon-Jai Lee, Jeung Hee An

Subject: Chemistry And Materials Science, Food Chemistry Keywords: anticancer activity; apoptosis; oleanolic acid; cell cycle arrest; mapk signaling

Online: 31 May 2017 (11:28:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1979.v1

The Impact of Gel Parameters on the Dispersal and Fragmentation of Hyaluronic Acid Gel Fillers Within an Artificial Model of Arterial Embolism

Danny J Soares, Alec D McCarthy

Subject: Medicine And Pharmacology, Other Keywords: vascular occlusion; arterial embolism; dermal filler injuries; soft tissue ischemia

Online: 25 July 2024 (11:04:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0553.v1

Surface-Coated PVDF@TAPEG Selective Ultrafiltration Membranes: An Investigation on Membranes’ Hydrophilicity and Antifouling Characteristics for Effective Humic Acid Removal from Wastewater

Leila Emadinezhad, Bita Ayati

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: wastewater treatment; tannic acid coating; polyvinylidene fluoride membrane; hydrophilicity; Humic acid separation.

Online: 8 April 2024 (16:04:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1111.v1

The Development of Sustainable polyoxymethylene(POM)-Based Composites by the Introduction of Natural Fillers and Melt Blending with Poly(lactic Acid)-PLA

Anna Soćko, Jacek Andrzejewski

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: polymer composites; polyoxymethylene; poly(lactic acid); natural fillers; polymer blends; mechanical properties; thermal resistance; reactive modifiers; injection molding

Online: 21 March 2024 (04:41:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0761.v1

A Screen-Printed Voltammetric Sensor Modified with Electropolymerized Molecularly Imprinted Polymer (eMIP) to Determine Gallic Acid in Non-alcoholic and Alcoholic Beverages.

Giancarla Alberti, Camilla Zanoni, Lucrezia Virginia Dallù, Clementina Costa, Alessandra Cutaia

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Gallic Acid; polyphenols; electrosynthesized Molecularly imprinted Polymer (eMIP); screen-printed electrodes; Electroanalysis; differential pulse voltammetry; voltammetric sensors; non-alcoholic and alcoholic beverages

Online: 13 March 2024 (07:10:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0874.v1

Utilization of Waste Natural Fiber Mixed with Polylactic Acid (PLA) Bicomponent Fiber: Incorporating Kapok and Cattail Fiber for Nonwoven Medical Textile Applications

Tanyalak Srisuk, Khanittha Charoenlarp, Piyaporn Kampeerapappun

Subject: Chemistry And Materials Science, Paper, Wood And Textiles Keywords: cattail fiber; kapok fiber; polylactic acid; nonwoven; hot-press; bicomponent fiber

Online: 12 December 2023 (10:26:26 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202309.1957.v1

SALIQ in Rhabdomyosarcoma: A Repurposed Multidrug Regimen to Augment Standard Treatments by Adding Simvastatin, All Trans Retinoic Acid, Lithium, Itraconazole, and Quercetin

Richard E. Kast, Mohamed S. Zaghloul, Iacopo Sardi, Marc-Eric Halatsch

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: chemotherapy; repurposed drugs; rhabdomyosarcoma

Online: 28 September 2023 (07:39:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1699.v1

The Effects of Transplantation of the Spaceflight Intestinal Microbiome on Short Chain Fatty Acid Production, Lymphoid organ Immune Composition and Transport Kinetics

Reid Powell, Mark Endsley, Walter Emerson Cromer

Subject: Biology And Life Sciences, Life Sciences Keywords: microbiome; spaceflight; lymphatic; short chain fatty acid; trascriptome

Online: 25 July 2023 (10:46:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1288.v1

Use of In-situ and Ex-situ Characterization Techniques to Study the Effects of Acid Diffusion on Physical Properties of Polymer Composites.

Sebastian Tamayo-Vegas, Khalid Lafdi, Mostapha Tarfaoui, Khalil K Lafdi, Mohamed Daly

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Polymer Composites; Nanoindentation; Vector Network Analyzer; Acid Diffusion; Structural Health Monitoring; Free Space Characterization.

Online: 18 May 2023 (07:29:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0207.v1

Response Surface Optimisation for the Development of Novel Ganoderic Acid Encapsulated Nanodispersions Using the Combination of Ultrasonic Cavitation and Solvent Evaporation Strategies

Wai Kit Cheng, Khang Wei Tan, Siah Ying Tang, Poh Guat Cheng, Cheng Heng Pang, Yang Tao, Sivakumar Manickam

Subject: Engineering, Chemical Engineering Keywords: Ganoderic acid; Nanodispersion; Ultrasound; RSM; Solvent evaporation; Encapsulation

Online: 11 April 2023 (07:32:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0049.v2

Human Remains Identification Using Micro-CT, Chemometric and A.I. Methods in Forensic Experimental Reconstruction of Dental Patterns after Concentrated Acid Significant Impact

Andrej Thurzo, Viera Jančovičová, Miroslav Hain, Milan Thurzo, Bohuslav Novák, Helena Kosnáčová, Viera Lehotská, Ivan Varga, Norbert Moravanský

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: dental pattern; forensic anthropology; forensic odontology; forensic dentistry; forensic radiolo-gy; forensic chemistry; forensic science; machine learning; identification; dental materials; acid solution; dissolution; sulfuric acid; dentition; teeth; acid degradation

Online: 24 February 2022 (03:41:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0291.v1

Design and Synthesis of Novel Peptides to Protect Ferulic Acid Against Ultraviolet Radiation Based on Domain Site IIA of Bovine Serum Albumin

Yinghan Wu, Hisham N. Farrag, Tamaki Kato, Hua Li, Shinya Ikeno

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: ferulic acid; UVA light; cyclic peptide; bovine serum albumin

Online: 13 August 2021 (08:48:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0244.v1

Evolutionary History of the GH3 Family Based on 48 Sequenced Plants and Identification of Jasmonic Acid-Relate GH3 Genes in Solanum tuberosum

Chao Zhang, Leilei Zhang, Dongdong Wang, Haoli Ma, Bailin Liu, Zheng Shi, Xiaohui Ma, Yue Chen, Qin Chen

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: GH3 family; sequencing plants; potato; jasmonic acids; tissues; biotic

Online: 17 May 2018 (12:01:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0087.v1

Hypoglycemic Effects in Alloxan-Induced Diabetic Rats of the Phenolic Extract Enriching Ellagic Acid, Kaempferol and Their Derivatives from Mongolian Oak Cups

Peipei Yin, Yu Wang, Lingguang Yang, Jinling Sui, Yujun Liu

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Mongolian oak cups; ethanol crude extract (ECE); ellagic acid- and kaempferol-derivatives; alloxan-induced rats; type 1 diabetes; hypoglycemic effect

Online: 8 April 2018 (08:45:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0279.v1

In Vitro Combinatorial Activity of Direct Acting Antivirals and Monoclonal Antibodies against the Ancestral B.1 and BQ.1.1 SARS-CoV-2 Viral Variants

Lia Fiaschi, Camilla Biba, Ilenia Varasi, Niccolò Bartolini, Chiara Paletti, Federica Giammarino, Francesco Saladini, Maurizio Zazzi, Ilaria Vicenti

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; mAbs; DAA; Combination antiviral therapy; In vitro synergism; Omicron variant

Online: 3 January 2024 (19:28:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0152.v1

Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Massimo Sangiorgi, Mariangela Valentina Puci, Allegra Rosa Martelli, Teresa Messina, Paolo Frigatti, Maria Pia Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco Michelino Fiore, Armado Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, Diego Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Pietro Modugno, Maurizio Maiorano, Umberto Marcello Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, Giovanni Maria Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munaó, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio Stefano Tolva, Ilenia D'Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D'Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio Massimo Oddi, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: chronic limb-threatening ischemia; outcome; sex; age; limb salvage

Online: 8 December 2022 (09:39:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.0541.v1

Evaluating Atlantic Salmon (Salmo salar) as a Natural or Alternative Host for Piscine Myocarditis Virus (PMCV) Infection

Ingvild B. Nyman, Øystein Wessel, Håvard Bjørgen, Marta Alarcon, Torstein Tengs, Espen Rimstad

Subject: Biology And Life Sciences, Aquatic Science Keywords: piscine myocarditis virus (PMCV); Salmo salar; Totivirus

Online: 8 July 2024 (15:07:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0033.v1

Is Confucius a Philosopher or a Saint? Michele Ruggieri’s Views from his Translations of the Four Books

Huiyu Wang

Subject: Arts And Humanities, Religious Studies Keywords: Michele Ruggieri; views of Confucius; the Four Books; Chinese Philosophy

Online: 1 July 2024 (07:32:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0828.v1

Dosing Cefazolin for Surgical Site Infection Prophylaxis in Adolescent Idiopathic Scoliosis Surgery: Intermittent Bolus or Continuous Infusion?

Yichao Yu, F. Cole Dooley, Anna Woods, Amy Gunnett, Cynthia Garvan, Stephanie Ihnow, Laurel C. Blakemore, Taran Sangari, Christoph N. Seubert

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: idiopathic scoliosis; surgery; cefazolin; pharmacokinetic; microdialysis

Online: 13 May 2024 (11:46:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1916.v1

TIM3 or HAVCR2 in Breast Cancer Instead of Suppression May Invoke Immune Action in Tumor Micro Environment

ANUPAM BASU, ARUNITA GHOSH, Barnali Dolui, Banani Majumdar, Pallavi Krishna, Arghya Bandopadhaya

Subject: Biology And Life Sciences, Life Sciences Keywords: Breast Cancer; ; Triple negative breast cancer; T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3); HAVCR-2; TCGA; BRCA; TIMER2.0; UALCAN; GEPIA

Online: 29 January 2024 (02:11:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1162.v1

Impact of Statins on the Survival of Patients with Advanced Hepatocellular Carcinoma Treated with Sorafenib or Lenvatinib

Hyo Jung Cho, Ji Eun Han, Jisu Kim, Jae Youn Cheong, Soon Sun Kim, Sun Gyo Lim, Min Jae Yang, Choong-Kyun Noh, Gil Ho Lee, Jung Woo Eun, Bumhee Park

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: statin; multityrosine kinase inhibitor; sorafenib resistance; hepatocellular carcinoma; lipophilic statin; hydrophilic statin

Online: 15 December 2023 (12:14:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0880.v1

Cape Verde: Islands of Vulnerability or Resilience? A Transition from a MIRAB Model into a TOURAB One?

Eduardo Moraes Sarmento, Ana Lorga Da Silva

Subject: Business, Economics And Management, Economics Keywords: Small Island Developing States, Cape Verde, Tourism, MIRAB model, TOURAB model, SITE model

Online: 12 December 2023 (10:51:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1613.v1

Energy Storage in Power to Heat or Cold Applications – an Analysis of Electrical versus Thermal Energy Storage

Harald Mehling

Subject: Engineering, Energy And Fuel Technology Keywords: Energy system; decarbonization; heating; cooling; buildings; industry; thermal energy storage; PCM; demand-side management; economics

Online: 25 October 2023 (09:04:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0647.v1

An Exploration of Nurses’ Experience following a Face-to-Face or Web-Based Intervention on Patient Deterioration

Jeong-ah Kim, Linda K Jones, Daniel Terry, Clifford Connell

Subject: Public Health And Healthcare, Nursing Keywords: clinical simulation; web-based intervention; face-to-face intervention; patient deterioration; patient safety; nurses; FIRST2ACT

Online: 11 October 2023 (03:55:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1259.v1

Physiotherapy-Led Health Promotion Strategies for People with or at Risk of Cardiovascular Diseases: A Scoping Review

Etienne Ngeh Ngeh, Anna Lowe, Carol Garcia, Sionnadh McLean

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: physiotherapy; health promotion; cardiovascular diseases; risk factors; Interventions

Online: 19 September 2023 (07:10:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0184.v1

On the Use of a Non-Constant Non-Affine or Slip Parameter in Polymer Rheology Constitutive Modeling

Vasileios-Martin Nikiforidis, Dimitrios G. Tsalikis, Pavlos S. Stephanou

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: unentangled systems; constitutive modeling; materials functions; non-affine parameter; slip parameter; conformation tensor; NEMD simulations; atomistic simulations; polyethylene

Online: 14 September 2022 (02:54:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0189.v1

Performance of a Chest Radiography AI Algorithm for Detection of Missed or Mislabeled Findings: A Multicenter Study

Parisa Kaviani, Subba R. Digumarthy, Bernardo Bizzo, Bhargava Reddy, Manoj Tadepalli, Preethan Putha, Ammar Jagirdar, Shadi Ebrahimian, Mannudeep K. Kalra, Keith J. Dreyer

Subject: Medicine And Pharmacology, Other Keywords: chest-X ray; sddendum; missed finding; radiology

Online: 10 August 2022 (04:17:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0551.v1

Fear, Peer Pressure, or Encouragement: Identifying Levers for Nudging Towards Healthier Food Choices in Multi-Cultural Singapore

Kum-Seong Wan, Bryan Jun-Keat Choo, Kwok-Fong Chan, Joshua Yi Yeo, Clare Shu-Lin Tan, Boon-Kiat Quek, Samuel Ken-En Gan

Subject: Social Sciences, Psychology Keywords: nudges; diet; healthy living; instant messaging; digital interventions

Online: 29 November 2021 (18:30:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0038.v1

Percutaneous Radiofrequency Ablation with or without Chemolipiodolization for Early-stage Hepatocellular Carcinoma: A Propensity Score-matched Analysis

Kota Takaki, Masahito Nakano, Kazuta Fukumori, Yoichi Yano, Yuki Zaizen, Takashi Niizeki, Kotaro Kuwaki, Masaru Fukahori, Takahiko Sakaue, Sohei Yoshimura, Mika Nakazaki, Takuji Torimura

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: hepatocellular carcinoma; percutaneous radiofrequency ablation; chemolipiodolization; risk factors; propensity score-matched analysis

Online: 4 October 2021 (10:19:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0280.v1

Comparative Genomic Analysis of the DUF34 Protein Family Suggests Role as a Metal Ion Chaperone or Insertase

Colbie Reed, Geoffrey Hutinet, Valérie de Crécy-Lagard

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: comparative genomics; metabolic reconstruction; bioinformatics; conserved unknowns; function prediction; functional annotation; orthology

Online: 13 July 2021 (08:58:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0194.v1

Mathematical Description of Elastic Phenomena which Uses Caputo or Riemann-Liouville Fractional Order Partial Derivatives is Nonobjective

Agneta M. Balint, Stefan Balint, Silviu Birauas

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: objectivity of a mathematical description; elastic phenomena description; fractional order partial derivative

Online: 7 August 2020 (11:43:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0125.v1

Matrix-based Approaches for Updating Approximations in Neighborhood Multigranulation Rough Sets while Neighborhood Classes Decreasing or Increasing

Peiqiu Yu, Hongkun Wang, Jinjin Li, Guoping Lin

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: Approximation computation; Multigranulation rough set; Knowledge acquisition; Decision making;

Online: 5 August 2020 (10:28:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202007.0743.v1

Efficacy of Non-Halofuginone-Based Strategies to Prevent or Treat Cryptosporidiosis in Bovine Calves: A Systematic Review

Julii Brainard, Charlotte C. Hammer, Kevin Tyler, Paul R. Hunter

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: chemoprophlaxis; calves; cryptosporidiosis; diarrhea; dairy

Online: 31 July 2020 (10:32:09 CEST)

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Working Paper ARTICLE

COVID-19 Perfect Storm (Part II): Role of Vitamins as Therapy or Preventive Strategy in Aged People

Sirio Fiorino, Claudio Gallo, Maddalena Zippi, Sergio Sabbatani, Roberto Manfredi, Renzo Moretti, Elisa Fogacci, Caterina Maggioli, Francesca Travasoni Loffredo, Enrico Giampieri, Ivan Corazza, Christoph Dickmans, Claudio Denitto, Michele Cammarosano, Michele Battilana, Paolo Emilio Orlandi, Francesco Del Forno, Francesco Miceli, Michela Visani, Giorgia Acquaviva, Paolo Leandri, Elio Jovine, Roberto Iovine, Dario de Biase

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: SARS; CoV-2; COVID-19; vitamins; therapeutic strategy

Online: 18 May 2020 (12:51:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0018.v1

The Aggregation Conditions Define Whether EGCG Is an Inhibitor or Enhancer of α-Synuclein Amyloid Fibril Formation

Rebecca Sternke-Hoffmann, Alessia Peduzzo, Najoua Bolakhrif, Rainer Haas, Alexander K. Buell

Subject: Biology And Life Sciences, Biophysics Keywords: amyloid; α-synuclein; EGCG; inhibition

Online: 3 February 2020 (05:45:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints201905.0285.v1

The Neuro-Immune Fingerprint of Major Neuro-Cognitive Psychosis or Deficit Schizophrenia: A Supervised Machine Learning Study

Hussein Al-Hakeim, Abbas Almulla, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Deficit schizophrenia, machine learning, cytokine, cognition, Immunological biomarkers

Online: 23 May 2019 (16:25:44 CEST)

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No studies have examined the immune fingerprint of major neuro-cognitive psychosis (MNP) or deficit schizophrenia using M1 macrophage cytokines in combination with chemokines such as CCL-2 and CCL-11. The present study delineated the neuro-immune fingerprint of MNP/deficit schizophrenia by analyzing plasma levels of IL-1β, sIL-1RA, TNF-α, sTNFR1, sTNFR2, CCL-2 and CCL-11 in MNP (n=120) versus healthy controls (n=54) in association with neurocognitive deficits (as assessed with the Brief Assessment of Cognition in Schizophrenia) and PHEMN (psychotic, hostility, excitation, mannerism and negative) symptoms. All immune biomarkers were significantly higher in MNP than in normal controls. MNP was best predicted by a combination of CCL-11, TNF-α, IL-1β and sIL-1RA which yielded a bootstrapped (n=2000) area under the Receiver Operating Curve of 0.985. Composite scores reflecting M1 macrophage activity and neurotoxic potential including combined effects of CCL-11 plus CCL-2 were significantly increased in MNP. Nevertheless, the effects of increased IL-1β and TNF-α in MNP were attenuated (statistically) by increased sIL-1RA and sTNFR2, two negative immune-regulatory markers. A large part of the variance in PHEM (38.4%-52.6%) and negative (65.8-7439%) symptoms was explained by combinations of immune markers whereby CCL-11 was consistently the most important. The immune markers also explained a large part of the variance in the Mini Mental State examination, list learning, digit sequencing task, category instances, controlled word association, symbol coding and Tower of London. Soft Independent Modeling of Class Analogy performed on the biomarkers showed that the inter-class distance between the models constructed around MNP and controls was 19.3 indicating a good separation. Partial Least Squares analysis showed that 72.7% of the variance in overall phenomenology was explained by the regression on IL-1β, sIL-1RA, CCL-11, TNF-α (all positively) and education (inversely). It is concluded that the combination of the above-mentioned markers defines MNP as a distinct neuro-immune disorder and that those markers in combination explain a large part of the variance in memory and executivive impairments and PHEMN symptoms.

Preprint ARTICLE | doi:10.20944/preprints202409.0869.v1

Effects of Cognitive Dual-Tasking on Biomechanics and Neuromuscular Control during the Transition to Walking from Standing or Sitting Postures in Young Adults

Angeloh Stout, Kaye Mabbun, Ke'Vaughn Waldon, Marvin Alvarez, Stacy Nguyen, Miguel Barcellano, Sandra Cuenca, Chuan-Fa Tang, Aanand Naik, Gu Eon Kang

Subject: Engineering, Bioengineering Keywords: Dual-Task; Gait Initiation; Sit-to-Walk; Hesitation; Anticipatory Postural Adjustment

Online: 11 September 2024 (07:32:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1388.v1

Exploring End-of-Life Care for Patients with Breast Cancer, Dementia or Heart Failure: A Register-Based Study of Individual and Institutional Factors

Terje P. Hagen, Erika Zelko

Subject: Public Health And Healthcare, Health Policy And Services Keywords: End-of-life care; palliativ care; social and long-term care; Norway

Online: 22 March 2024 (16:53:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.2063.v1

Multi-Echo Complex Quantitative Susceptibility Mapping and Quantitative Blood Oxygen Level Dependent Magnitude (mcQSM+qBOLD or mcQQ) for Oxygen Extraction Fraction (OEF) Mapping

Junghun Cho, Jinwei Zhang, Pascal Spincemaille, Hang Zhang, Thanh D. Nguyen, Shun Zhang, Ajay Gupta, Yi Wang

Subject: Engineering, Bioengineering Keywords: oxygen extraction faction; quantitative susceptibility mapping; quantitative blood oxygen level-dependent imaging; multi-echo complex quantitative susceptibility mapping and quantitative blood oxygen level dependent magnitude; QSM+qBOLD; QQ; mcQQ; deep learning; magnetic resonance imaging; MRI

Online: 27 December 2023 (09:10:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0931.v1

Evaluation of Growth Performance and Environmental Impact of Hermetia illucens Larvae Reared on Coffee Silverskin Enriched with Schizochytrium limacinum or Isochrysis galbana Microalgae

Ruschioni Sara, Duca Daniele, Tulli Francesca, Zarantoniello Matteo, Cardinaletti Gloriana, Corsi Lorenzo, Olivotto Ike, Basili Danilo, Simona Naspetti, Cristina Truzzi, Nunzio Isidoro, Riolo Paola

Subject: Biology And Life Sciences, Insect Science Keywords: Hermetia illucens; growth performance; sustanability; coffee sirvelskin; microalgae

Online: 16 October 2023 (08:01:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0432.v1

Early Versus Late Caffeine and/or Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) for Prevention of Intermittent Hypoxia Induced Neuroinflammation in the Neonatal Rat

Myra Batool, Charles L. Cai, Jacob V. Aranda, Kay D. Beharry

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Brain; Caffeine; Cytokines; Ibuprofen; Intermittent Hypoxia; Myelination; Neuroinflammation; Non-steroidal Anti-inflammatory Drugs

Online: 6 September 2023 (11:12:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0341.v1

Safety and Tolerability of Six Months of Isoniazid or Three Months of Rifampicin for Tuberculosis Among Subjects With Diabetes Mellitus: A Randomized Trial

Karla Tamez-Torres, Norma Mongua-Rodríguez, Leticia Ferreyra-Reyes, Pedro Torres-González, Guadalupe Delgado-Sánchez, Maribel Martínez-Hernández, Miriam Bobadilla-del-Valle, Velma Jasso-Sosa, Priscila López-Castillo, Elizabeth Ferreira-Guerrero, Pablo Cruz_Hervert, José Sifuentes-Osornio, Carlos Aguilar-Salinas, Lourdes García-García, Alfredo Ponce-de-Leon

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: tuberculosis infection; tuberculosis disease; tuberculosis preventive treatment; latent tuberculosis infection; diabetes mellitus; adverse events; isoniazid; rifampicin; randomized controlled trial

Online: 5 June 2023 (15:01:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202006.0330.v3

Structural, Functional, and Metabolic Brain Differences as a Function of Gender Identity or Sexual Orientation: A Systematic Review of the Human Neuroimaging Literature

Alberto Frigerio, Lucia Ballerini, Maria Del C. Valdés Hernández

Subject: Social Sciences, Psychology Keywords: Brain; Neuroimaging; Transgender; Transsexual; Gender Identity; Homosexual; Heterosexual

Online: 8 April 2021 (10:14:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0430.v2

To Serum or Not to Serum: Reduced-serum Based Approaches for Contact-based Co-culture of Fibroblasts and Keratinocytes for Wound Bed Studies

Snehal Kadam, Madhusoodhanan Vandana, Karishma Kaushik

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Co-culture; Reduced-serum; Wound bed; Fibroblasts; Keratinocytes

Online: 12 March 2020 (13:24:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints201704.0156.v1

Ranolazine alone or as a complement to the amiodarone for both prevention and cardioversion of atrial fibrillation: A meta-analysis of the literature

Renato De Vecchis, Carmelina Ariano

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: ranolazine; atrial fibrillation; prevention; pharmacological cardioversion; meta-analysis

Online: 25 April 2017 (07:48:26 CEST)

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Introduction Recent evidence from relatively small randomized controlled trials would seem to support a useful role of ranolazine for the prevention and treatment of atrial fibrillation (AF). The present study is aimed at providing information about the possible beneficial anti-arrhythmic properties of ranolazine. In particular, the meta-analysis carried out in this study focuses on the application of ranolazine to prophylaxis and treatment of atrial fibrillation.Methods Both randomized controlled trials (RCTs) and non randomized observational studies concerning the effects of ranolazine on AF were included in the meta-analysis. In each of the considered studies, a comparison was made between a group of patients taking ranolazine and a second group treated instead with another antiarrhythmic therapy , or assigned to placebo. Efficacy outcomes were the risk of new- onset AF, the probability of conversion to sinus rhythm of patients with recent occurrence(≤ 48 h)of AF and the time to conversion to sinus rhythm. Safety endpoints were death, adverse events, QTc prolongation and hypotension.Results Ten studies ( 8 RCTs and 2 nonrandomized observational studies) were gathered on the whole. Ranolazine was effective in preventing the occurrence of AF when compared to controls (RR= 0.60; 95% CI: 0.43–0.83; p = 0.002). Subgroup analysis showed a more pronounced preventive effect of ranolazine against AF in the postoperative setting of coronary artery bypass grafting(CABG) surgery (RR= 0.39; 95% CI: 0.18-0.83; p=0.02) when compared to non- postoperative AF (RR= 0.76; 95% CI: 0.63-0.92; p=0.04). Ranolazine enhanced the chances of successful cardioversion when added to intravenous amiodarone compared to amiodarone alone (RR 1.18; 95% CI: 1.05–1.33; p = 0.004) and significantly decreased the time to cardioversion(SMD= −10.35 h; 95% CI: −18.13 hours to − 2.57 hours; p < 0.001). Overall risks of death, adverse events, and QTc prolongation were shown to be similar in the comparison between patients treated with ranolazine and controls. Conclusions Ranolazine given orally at appropriate doses showed the property to significantly quicken the conversion of AF to sinus rhythm when combined with the iv amiodarone, compared to iv amiodarone alone . Furthermore, in patients in sinus rhythm, ranolazine proved to reduce the frequency of new onset AF as well as of its recurrences, especially in patients undergone CABG surgery, known to be at high risk of developing postoperative AF. In addition, ranolazine use seems to be safe and associated with relatively few adverse events.

Preprint ARTICLE | doi:10.20944/preprints202409.0607.v1

Strongly ROS-Correlated, Time-Dependent and Selective Antiproliferative Effects of Synthesized Nano Vesicles on BRAF Mutant Melanoma Cells and Their Hyaluronic Acid-Based Hydrogel Formulation

Silvana Alfei, Guendalina Zuccari, Constantinos M. Athanassopoulos, Cinzia Domenicotti, Barbara Marengo

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: cutaneous metastatic melanoma (CMM); triphenyl phosphonium (TPP) groups; mitochondria-targeting molecules; nanosized bola-amphiphiles vesicles; cytotoxicity studies; low hemolytic effects; hydrogel formulation; biodegradability; high porosity; high swelling

Online: 9 September 2024 (09:03:54 CEST)

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Cutaneous metastatic melanoma (CMM) is the most aggressive form of skin cancer with a poor prognosis. Drugs-induced secondary tumorigenesis and the emergency of drug resistance worsen the already worrying scenario, thus rendering urgent the development of new treatments, not dealing with mutable cellular processes. Triphenyl phosphonium salts (TPPSs), in addiction to act as cytoplasmic membrane disruptors, are reported to be mitochondria-targeting compounds, exerting anticancer effects mainly by damaging their membranes and causing depolarization, impairing mitochondria functions and their DNA, triggering oxidative stress (OS), and priming primarily apoptotic cell death. TPP-based bola-amphiphiles are capable to self-form nanoparticles (NPs) with enhanced biological properties, as commonly observed for nanomaterials. Already employed in several other biomedical applications, only recently the per se selective potent antibacterial effects of a TPP bola-amphiphile has been demonstrated on 50 multidrug resistant (MDR) clinical superbugs, as well as its exceptional and selective anticancer properties, on sensitive and MDR neuroblastoma cells. Here, aiming at finding new molecules possibly developable as new treatments for counteracting CMM, the effects of this TPP-based bola-amphiphile (BPPB) have been investigated against two BRAF mutants CMM cell lines (MeOV and MeTRAV) with excellent results (even IC50 = 49 nM on MeOV after 72 h treatment). Upon these findings and considered the low cytotoxicity of BPPB against different mammalian not tumoral cell lines and red blood cells (RBCs, selectivity indexes up to 299 on MeOV after 72 h treatment), the possible future development of BPPB as topical treatment for CMM lesions was presumed. In this sight, a biodegradable hyaluronic acid (HA)-based hydrogel formulation (HA-BPPB-HG) was prepared without using any potentially toxic crosslinking agents, but simply dispersing suitable amounts of the two ingredients in water and sonicating under gentle heating. HA-BPPB-HA was completely characterized with promising outcomes, such as high swelling capability, high porosity and viscous elastic rheological behavior.

Preprint ARTICLE | doi:10.20944/preprints202401.1286.v1

A Uplc-Ms/Ms Method for Intracellular Concentration Determination of Mycophenolic Acid and Its Metabolites： Analytical Validation and Clinical Assessment in Infected Kidney Transplant Recipients.

Xiaomei Chen, Chunxia Chen, Shenling Liao, Shaohui Ma, Xinhua Dai, Xueqiao Wang, Huan Xu, Yi Li, Yangjuan Bai

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: UPLC-MS/MS; MPA; MPAG; AcMPAG; PBMC; Infection

Online: 17 January 2024 (08:24:56 CET)

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Abstract: (1) Background: No consensus has been reached on indicators and protocols for monitoring drug concentrations in organ transplant recipients for the immunosuppressant mycophenolic acid (MPA) in clinical therapy.In this study, we propose to establish a Ultra Performance Liquid Chromatography–Tandem Mass Spectrometry (UPLC-MS/MS) for quantitative determination of MPA and its metabolites ( mycophenolic acid carboxybutoxyether, MPAG and mycophenolic acid carboxyglucuronide, AcMPAG) concentrations in peripheral blood mononuclear cells (PBMCs) and to assess the clinical application of PBMCs concentration detection of MPA and its metabolites in infection prediction in Chinese kidney transplant recipients(KTRs); (2) Methods: PBMCs were isolated with Ficoll-Paque solution, and cells were counted. Acetonitrile precipitated proteins to extract the target compounds.Waters ACQUITY UPLC BEH C18 column of 1.7μm (2.1 mm*50 mm) and an ACQUITY-Xevo TQ-S UPLC-MS/MS system were used for the detection with mobile phases: water and methanol (containing 2 mmol/L NH4Ac + 0.1% formic acid); flow rate: 0.3 mL/min. After gradient elution, the samples were positively ionized by an electrospray positive ion source (ESI) and then quantitatively analyzed by a triple quadrupole tandem mass spectrometer in multiple reaction monitoring (MRM) mode. The performance of the established method was evaluated through a series of validation experiments according to the requirements of the relevant guidelines. We enrolled 7 KTRs with stable conditions and 8 KTRs with infection from August to November 2022, who were treated at the West China Hospital of Sichuan University.Their peripheral blood samples were collected and detected MPA, MPAG, and AcMPAG concentrations in PBMCs using the methods mentioned above and evaluated for their clinical application in the prediction and monitoring of infections in KTRs; (3) Results: After validation of the methodology, the UPLC-MS/MS method established in this study for the determination of MPA, MPAG, and AcMPAG concentrations in PBMCs showed good linearity in the quantitative ranges of 0.0625-50 ng/ml, 0.5-50 ng/ml and 0.1-20 ng/ml, and the selectivity, specificity, matrix effect, carry-over contamination, reproducibility, precision and accuracy all satisfied the requirements.AcMPAG in PBMCs was poorly stabilized and showed significant degradation after -80°C storage for 24 h or 3 cycles of freeze-thaw.There was a large variability in MPA and MPAG concentrations in PBMCs of KTRs and it correlated poorly with plasma MPA concentrations (rs=0.206,p=0.117).Subgroup analysis showed that the correlation between MPA in plasma and PBMCs was still poor in the infected group(rs=0.201,p=0.116), but significant correlation in the stable group (rs=0.643,p=0.001). A significantly higher level of MPA in PBMCs was observed in the infected group than those in the stable group at 2h and 4h after drug dosing (p<0.05).AcMPAG concentrations in PBMCs of KTRs were extremely low and virtually undetectable.ROC curve analysis (area under the curve, AUC) was performed for infection after renal transplantation with indicators of significant difference showed that the area AUC for PBMCs-MPA-C4 was 0.928 ,for PBMCs-MPA-C2 was 0.875,and for Plasma-MPA-C4 was 0.803; (4) Conclusions: In this study, a method based on UPLC-MS/MS was developed and validated for the simultaneous determination of MPA, MPAG, and AcMPAG concentrations in PBMCs.With easy operability and good stability, this method provides a reliable analytical method for the clinical implementation of the detection of MPA, MPAG, and AcMPAG concentrations in PBMCs.The concentrations of MPA and MPAG in PBMCs from KTRs were highly variable and were closely associated with the development of infections after renal transplantation.Monitoring MPA and MPAG in PBMCs may be useful indicators for mycophenolic acid therapeutic drug concentration monitoring (TDM) in KTRs.

Preprint ARTICLE | doi:10.20944/preprints202312.0485.v1

Effects of Plant Polysaccharides Combined with Boric Acid on Digestive Function, Immune Function, and Harmful Gas and Heavy Metal Contents in Faeces of Finishing Pigs

Juan Deng, Feng Zhang, Haoran Fan, Yuxuan Zheng, Chufang Zhao, Man Ren, Erhui Jin, Youfang Gu

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Plant polysaccharides; Boric acid; finishing pigs; Digestive enzymes; Immune; Antioxidant; Harmful gases

Online: 7 December 2023 (16:44:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1634.v1

Postharvest Application of Carvone, Abscisic Acid, Gibberellin, and Variable Temperature for Regulating Dormancy Release and Sprouting Commencement of Mini-Tuber Potato Seeds Produced Under Aeroponics

Tiandi Zhu, Huaidi Pei, Zhongwang Li, Minmin Zhang, Chen Chen, Shouqiang Li

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Mini-tuber potato; Dormancy; Sprouting; Carvone; Abscisic acid; Gibberellin; Variable temperature

Online: 26 October 2023 (03:21:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2231.v1

Interactive Effects of Ceftriaxone and Chitosan Immobilization on the Production of Arachidonic Acid by and the Microbiome of the Chlorophyte Lobosphaera sp. IPPAS C-2047

Svetlana Vasilieva, Alexandr Lukyanov, Christina Antipova, Timofei Grigoriev, Elena Lobakova, Olga Chivkunova, Pavel Scherbakov, Petr Zaytsev, Olga Gorelova, Tatiana Fedorenko, Dmitry Kochkin, Alexei Solovchenko

Subject: Biology And Life Sciences, Life Sciences Keywords: Lobosphaera; attached cultivation; antibiotics; bioremoval, arachidonic acid

Online: 31 May 2023 (11:00:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0348.v1

3-Methoxycarpachromene and Masticadienonic Acid as New Target Inhibitors from Pistacia atlantica Leaves against Trypanothione Reductase of Leishmania Parasites: In Vitro and In Silico Studies

Saarra Maamri, Khedidja Benarous, Mohamed Yousfi

Subject: Biology And Life Sciences, Parasitology Keywords: Pistacia atlantica leaves; L. infantum; L. major; promastigote; antileishmanial; Masticadienonic acid, 3-Methoxycarpachromene; molecular docking.

Online: 14 May 2021 (15:36:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0135.v1

Increased Levels of Plasma Tumor Necrosis Factor-α Mediate Schizophrenia Symptom Dimensions and Neurocognitive Impairments and Are Inversely Associated with Natural IgM and Paraoxonase 1 Activity

Michael Maes, Sunee Sirivichayakul, Andressa Keiko Matsumoto, Annabel Maes, Ana Paula Michelin, Laura de Oliveira Semeão, João Victor de Lima Pedrão, Estefania G. Moreira, Decio S. Barbosa, Michel Geffard, Andre F. Carvalho, Buranee Kanchanatawan

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: cytokines, neuro-immune, inflammation, antioxidants, oxidative stress, paraoxonase 1

Online: 12 November 2019 (17:02:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints201812.0198.v1

Deregulation of VEGFR-2 and PGFR Expression and Microvascular Density in a Triple-Negative Model of Canine Malignant Mammary Tumors with Lymph Node or Lung Metastasis

Denner Santos Anjos, Aline Fernandes Vital, Patricia de Faria Lainetti, Antonio Fernando Leis-Filho, Fabiola Dalmolin, Fabiana Elias, Sabryna Gouveia Calazans, Carlos Eduardo Fonseca-Alves

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Angiogenesis; metastasis; mammary neoplasm

Online: 17 December 2018 (15:20:52 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0263.v1

Comprehensive Cardiovascular Management of Myotonic Dystrophy Type 1 Patients: A Report from Italian Neuro-Cardiology Network

Vincenzo Russo, Giovanni Antonini, Roberto Massa, Casali Carlo, Alfredo Mauriello, Annamaria Martino, Roberto Marconi, Matteo Garibaldi, Pasquale Franciosa, Massimo Zecchin, Carlo Gaudio, Antonello D’Andrea, Stefano Strano

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Myotonic Dystrophy; Cardiovascular Disease; Neurological Disease; Sudden Cardiac Death; Arrythmogenic risk.

Online: 3 January 2024 (12:58:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0412.v1

A New, Rapid, Colorimetric Chemodosimeter, 4(pyrrol-1-Yl)pyridine, for Nitrite Detection in Aqueous Solution

Mallory E. Thomas, Lynn D. Schmitt, Alistair J. Lees

Subject: Chemistry And Materials Science, Food Chemistry Keywords: aggregate; chemodosimeter; limit of detection; nitrite

Online: 6 December 2023 (10:58:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0462.v1

Cisplatin Dependent Secretion of Immunomodulatory High Mobility Group Box 1 (HMGB1) Protein from Lung Cancer Cells

Kevin Gillespie, Ross Pirnie, Clementina Mesaros, Ian Blair

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Platinum drugs; acetylation; oxidation; immune response; mass spectrometry; chromatography

Online: 7 August 2023 (10:10:09 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202305.0609.v1

Encephalopathy Caused by Human Parvovirus B19 Genotype 1 Associated With Haemophilus influenzae Meningitis in a Newborn

Noely E. Ferreira, Antonio Charlys Da Costa, Esper Kallas, Cassia G.T. Silveira, Ana Carolina Soares, Layla Honorato, Heuder Gustavo Oliveira Paiao, Silvia Helena Lima, Dewton M. Vasconcelos, Marina F. Côrtes, Silvia Figueiredo Costa, Tania Regina Tozetto-Mendoza, Hélio Rodrigues Gomes, Steven S. Witkin, Maria Cassia Mendes-Correa

Subject: Biology And Life Sciences, Virology Keywords: Human parvovirus B19; Encephalopathy; Metagenomic next-generation sequencing.

Online: 9 May 2023 (08:41:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0163.v1

The Interaction of Ribosomal Protein L22 with Epstein-Barr Virus-Encoded RNA-1 in Intracellular Transport

Zubaida Hassan, Pretty S. Philip, Bincy Baby, M. Kalim Akhtar, Anatoliy Shmygol, Gulfaraz Khan

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: EBER1; Intracellular transport; RPL22; Secretion; Structure

Online: 4 May 2023 (02:48:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0724.v1

PRRSV-1 Stabilization Programmes in French Farrow-to-Finish Farms: a Way to Reduce Antibiotic Usage

Charlotte Teixeira Costa, Pauline Berton, Gwenaël Boulbria, Valérie Normand, Mathieu Brissonnier, Arnaud Lebret

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: porcine reproductive and respiratory syndrome virus; health management; antibiotic usage; pig production sector; PRRSV-1 stabilization program

Online: 21 April 2023 (11:08:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0287.v1

HAX1 Is a Novel Binding Partner of Che-1/AATF. Implications in Oxidative Stress Cell Response

Cinzia Pisani, Annalisa Onori, Francesca Gabanella, Simona Iezzi, Roberta De Angelis, Maurizio Fanciulli, Andrea Colizza, Marco De Vincentiis, Maria Grazia Di Certo, Claudio Passananti, Nicoletta Corbi

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: HAX1; Che-1/AATF; apoptosis; mitochondria; oxidative stress; breast cancer; ERα

Online: 17 February 2023 (01:50:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0482.v1

Standard Gibbs Energy of Binding of the gp120 Antigen of HIV-1 to the CD4 Receptor

Marko Popovic

Subject: Biology And Life Sciences, Virology Keywords: Biothermodynamics of viruses; HIV-1; Binding constant; Gibbs energy of binding; Antigen-receptor binding

Online: 25 November 2022 (12:44:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202209.0008.v1

A Multi-agent Approach to Predict Long-Term Glucose Oscillation in Individuals with Type 1 Diabetes

João Paulo Aragão Pereira, Anarosa Alves Franco Brandão, Joyce da Silva Bevilacqua, Maria Lúcia Cardillo Côrrea-Giannella

Subject: Computer Science And Mathematics, Computer Science Keywords: Glucose Oscillation; Prediction; Multi-agent; Type 1 Diabetes; Personalized; Recommendation

Online: 1 September 2022 (07:13:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0319.v1

Unveiling the Mechanisms of High-temperature 1/2[111] Screw Dislocation Glide in Iron--Carbon Alloys

Ivaylo Hristov Katzarov, Ljudmil Borisov Drenchev

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: dislocations; diffusion; FeC; Dynamic strain aging

Online: 24 March 2022 (02:20:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0282.v1

The Impact of Retinal Configuration on the Protein-Chromophore Interactions in Bistable Jumping Spider Rhodopsin-1

Jonathan Richard Church, Jógvan Magnus Haugaard Olsen, Igor Schapiro

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: Rhodopsins; Bistable; Jumping Spider; QM/MM; Spectral Tuning

Online: 16 November 2021 (09:12:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0503.v1

Characterizations of Graded Rings Over Which Every Graded Semi-primary Ideal is Graded 1-absorbing Primary

Alaa Melhem, Malik Bataineh, Rashid Abu-Dawwas

Subject: Computer Science And Mathematics, Mathematics Keywords: Graded 1-absorbing primary ideals; graded primary ideals; graded semi-primary ideals.

Online: 26 August 2021 (09:57:50 CEST)

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