Search | Preprints.org

Preprint ARTICLE | doi:10.20944/preprints202401.1041.v1

Caries Experience in Both the Pre- and Post-Lockdown Periods During the COVID-19 Pandemic: An Observational Study

Eduardo Manuel Soares Guerreiro, João Botelho, Vanessa Machado, Luís Proença, José João Mendes, Ana Cristina Manso

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: dental caries; caries experience; COVID-19; prevalence; pandemic; epidemiology; decay missing filled index; dmf index

Online: 12 January 2024 (16:17:52 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202401.0832.v1

Seroprevalence of Anti-SARS-CoV-2 Antibodies in Cats during Five Waves of COVID-19 Epidemic in Thailand and Correlation with Human Outbreaks

Suporn Thongyuan, Jeeraphong Thanongsaksrikul, Potjanee Srimanote, Wallaya Phongphaew, Piyaporn Eiamcharoen, Naris Thengchaisri, Angela Bosco-Lauth, Nicola Decaro, Rungrueang Yodsheewan

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: COVID-19; SARS-CoV-2; indirect ELISA; surrogate viral neutralization assay; seroprevalence; correlation; Thai; cat

Online: 10 January 2024 (12:03:28 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202401.0745.v1

Placental Histopathological and Immunohistochemical Prompt Assessment after SARS-CoV-2 Infection during Pregnancy—Our Perspective over a Small Group

Daniela Eugenia Popescu, Ioana Roșca, Ana Maria Cristina Jura, Andreea Cioca, Ovidiu Pop, Nicoleta Lungu, Zoran Laurentiu Popa, Adrian Ratiu, Marioara Boia

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: placenta; SARS-CoV-2 infection; pregnancy; vertical transmission; fetal; pathology; immunohistochemistry; vascular complications; COVID-19.

Online: 9 January 2024 (15:45:56 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202312.1810.v1

On the Analytical Solution of the Sirv-Model for the Temporal Evolution of Epidemics for General Time-Dependent Recovery, Infection and Vaccination Rates

Martin Kröger, Reinhard Schlickeiser

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: epidemological model; nonlinear coupled differential equation; infinite sums; analytical solution; Covid-19; SIRV model; virus

Online: 25 December 2023 (10:31:41 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202312.1425.v1

Historical Perspectives in the Pedagogy of Anatomy Instruction in Medical and Graduate Education: From Salerno to Montserrat

Orien Tulp, Frantz Sainvil, Rolando Branly, Hailin Wu, George Einstein

Subject: Medicine And Pharmacology, Anatomy And Physiology Keywords: Anatomy; cadaveric dissection; prosection; virtual dissection; clinical integration; COVID-19 pandemic; fiberoptic examination; surface anatomy.

Online: 19 December 2023 (14:01:21 CET)

Show abstract| Download PDF| Share

Because the including of human anatomy forms the foundation for clinical medicine, it has contributed a pivotal role in medical education for many centuries. Thus with advancements in the science of modern, current day medicine, its continued place in the medical school curriculum deserves careful attention. In an attempt to provide guidance to decision-makers involved in clinical anatomy curriculum development at the medical school level, the Educational Affairs Committee of the American Association of Clinical Anatomists (AACA) developed this document, which defines the contours of a gross anatomy curriculum leading to the M.D. or D.O. degree. The main body of the document sets forth the anatomical concepts as well as the subject matter a student should master prior to graduation from medical school. Gross anatomy dissection is still a crucial topic in graduate and medical school. The nature and content of gross anatomy, which was historically regarded as a core course in the first year of medical education in MBBS, MD, DO, and some PhD and Graduate curricula as well as in other disciplines of selective graduate education and non-allopathic medical programs, have been significantly impacted by emerging challenges in the pedagogy of delivering medical education in the past ten years. A seemingly ever-increasing emphasis on additional modules in molecular biology, emerging pharmacotherapeutics and pathophysiology content have resulted in a condensation and apparent erosion of previously allotted classroom and laboratory hours in the gross anatomy curriculum. In addition, an imposition of financial constraints and a decreasing availability of sufficient cadaver donations to support gross anatomy dissection labs has also occurred in some locations. An innovative clinically focused cadaveric anatomy program is described which has improved the delivery and content retention of medical and graduate students and has become one of the most sought-after modules in the revised clinically oriented curriculum and has been deemed highly relevant to current medical education and graduate studies.

Preprint REVIEW | doi:10.20944/preprints202312.0663.v1

Radiation Overuse in Intensive Care Units: A Cause for Concern

Chiara Zanon, Costanza Bini, Alessandro Toniolo, Tommaso Benetti, Emilio Quaia

Subject: Medicine And Pharmacology, Other Keywords: Radiological Imaging; Radiation exposure; ICU patients; COVID-19; Optimization strategies; Cancer risk; Cumulative Effective Dose

Online: 11 December 2023 (06:08:24 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202311.1289.v1

Immune Signature of Patients With Cardiovascular Disease Predicts Increased Risk for a Severe Course of COVID-19

Manina Günter, Karin Anne Lydia Müller, Mathew J. Salazar, Sarah Gekeler, Carolin Prang, Tobias Harm, Meinrad P. Gawaz, And Stella E. Autenrieth

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: cardiovascular disease; SARS-CoV-2 infection; COVID-19; spectral flow cytometry; immuno-response; immune signature

Online: 21 November 2023 (09:36:57 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202310.0231.v3

Locus of Control and Self‐Directed Learning Readiness of Nursing Students During the COVID‐19 Pandemic: A Cross‐Sectional Study from Saudi Arabia

Hanan A. A. ALKORASHY, Hanan A. ALOTAIBI

Subject: Public Health And Healthcare, Nursing Keywords: locus of control; self-directed learning readiness; nursing students; Saudi Arabia; undergraduates; COVID-19 pandemic

Online: 14 November 2023 (15:29:13 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202311.0255.v1

Innovation and Sustainability in Business Turbulence: Navigating the ‘Now Normal’ through Value Co-creation

Ayantunji Gbadamosi, Nnamdi O Madichie, Emmanuel Mogaji

Subject: Business, Economics And Management, Marketing Keywords: COVID-19; Entrepreneurship; SMEs; Opportunity-necessity nexus; Value co-craetion; Now-normal; Sustainability; Turbulence; Innovation

Online: 3 November 2023 (14:34:23 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202311.0182.v1

BNT162b2 Booster Dose Elicits a Robust Antibody Response in Subjects with Abdominal Obesity and Previous SARS-CoV-2 Infection

Alexis Elias Malavazos, Carola Dubini, Valentina Milani, Sara Boveri, Chiara Meregalli, Caterina Bertolini, Carola Buscemi, Rosanna Cardani, Laura Valentina Renna, Manuel Bruno Trevisan, Valentina Scravaglieri, Maria Teresa Cuppone, Lorenzo Menicanti, Elena Costa, Federico Ambrogi, Chiara Ruocco, Michele Carruba, Gianluca Iacobellis, Enzo Nisoli, Massimiliano Marco Corsi Romanelli

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Abdominal obesity, obesity, BMI, BNT162b2 mRNA vaccine, antibody response, IgG-TrimericS, booster dose, COVID-19

Online: 2 November 2023 (14:42:21 CET)

Show abstract| Download PDF| Share

Preprint BRIEF REPORT | doi:10.20944/preprints202310.1543.v1

Studying the Effect of Anthropogenic Activities on the Presence of Nitrogen Dioxide (NO2) through Remote Sensing and Ground Based Observations over Emirate of Fujairah, UAE

Reem Yaqoub Yousif Ahmed Abdalla, Aseela AL Moalla, Mohamed Ateeg, Marwa Hossny, Fouad Lamghari, Shaher Bano Mirza

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: atmospheric pollution; NO2; air quality; Sentinel-5p; TROPOMI; remote sensing data; covid-19; pandemic, outbreak

Online: 25 October 2023 (05:20:13 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202309.0589.v1

Strengthening Resilient Built Environments through Human Social Capital: A Path to Post-Covid-19 Recovery

Oluwagbemiga Paul Agboola, Hourakhsh Ahmad Nia, Yakubu Aminu Dodo

Subject: Arts And Humanities, Architecture Keywords: human social capital; resilience built environment; COVID-19 pandemic; disaster management; structural equation modelling; Nigeria

Online: 11 September 2023 (04:55:05 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202309.0564.v1

Comparative Immune Response after Vaccination with SOBERANA® 02 and SOBERANA® plus Heterologous Scheme and Natural Infection in Young Children

Rocmira Perez-Nicado, Chiara Massa, Laura Rodriguez-Noda, Anja Mueller, Rinaldo Puga-Gomez, Yariset Ricardo-Delgado, Beatriz Paredes-Moreno, Meiby Rodríguez-González, Marylé García-Ferrer, Ilianet Palmero-Álvarez, Aniurka Garcés-Hechavarría, Daniel G. Rivera, Yuri Valdés-Balbín, Vicente Vérez-Bencomo, Dagmar García-Rivera, Barbara Seliger

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: SARS-CoV-2; COVID-19; Vaccine; Children; SARS-CoV-2 RBD IgG; Memory T cell

Online: 8 September 2023 (02:55:35 CEST)

Show abstract| Download PDF| Share

(1) Background: SARS-CoV-2 infection is mostly accompanied by mild COVID-19 symptoms in children. However, the multisystem inflammatory syndrome (MIS-C) and long-term sequelae are often severe complications. Therefore, the protection of the pediatric population against SARS-CoV-2 with effective vaccines is particularly important. Here we compare the humoral and cellular immune responses elicited in children (n=15) aged 5-11 years vaccinated with RBD-based vaccines combined in a heterologous scheme of SOBERANA® 02 and SOBERANA® Plus with those from children (n=10) aged 4-11 years who recovered from mild symptomatic COVID-19. (2) Methods: Blood samples were taken 14 days after last dose for vaccinated and 45-60 days after the infection diagnosis for COVID-19 recovered children. Anti-RBD IgG and ACE2-RBD inhibition were assessed by ELISA; IgA, cytokine and cytotoxic related proteins profile were determined by multiplex assays. Total B and T cell subpopulations and IFN-γ release were measured by multiparametric flow cytometry using a large panel of antibodies after in vitro stimulation with S1 peptides. (3) Results: Significant higher levels of specific anti-RBD IgG and IgA and ACE2-RBD inhibition capacity were found in vaccinated children in comparison to COVID-19 recovered children. Th1-like and Th2-like CD4+ T cells were also significantly higher in vaccinated subjects. IFN-γ secretion were higher in central memory CD4+ T cells of COVID-19 recovered children, but no differences between both groups were found in CD4+ and CD8+ T cells effector, terminal and naïve T cell subpopulations. High levels of IL-2, IL-6, IFN-γ and IL-10 in contrast to low levels of IL-4 suggesting a predominant Th1 cell polarization. Cytotoxic-related proteins granzyme A and B, perforin and granulin were also found in the supernatant after S1 stimulation in both vaccinated and recovered children. (4) Conclusions: Vaccination with the heterologous scheme of SOBERANA® 02/ SOBERANA® Plus induces strong antibody and cellular immune response compared to natural infections of young children.

Preprint ARTICLE | doi:10.20944/preprints202309.0387.v1

Reshaping the Canvas: Post-Pandemic Strategic Plan for Higher Education Institution

Edgar R. Eslit

Subject: Arts And Humanities, Humanities Keywords: college of arts and sciences; COVID-19 adaptation; internationalization; interdisciplinary collaboration; strategic planning; higher education

Online: 6 September 2023 (08:51:15 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202308.1547.v1

Unravelling Insights into the Evolution and Management of SARS-CoV-2: A Comprehensive Review

Aganze Mushebenge, Samuel C. Ugbaja, Nonkululeko Avril Mbatha, Rene M. Khan, Hezekiel M. Kumalo

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Main Protease Inhibitors; SARS-CoV-2; COVID-19; mutations; vaccines; therapeutics; drug repurposing; management strategies

Online: 22 August 2023 (09:31:05 CEST)

Show abstract| Download PDF| Share

Preprint HYPOTHESIS | doi:10.20944/preprints202308.1130.v1

The Long Covid-19 Syndrome the Spike Protein and Stem Cells, the Underrated Role of Retrotransposons, a Working Hypothesis

Mario G. Balzanelli, Pietro Distratis, Rita Lazzaro, Gianna Dipalma, Francesco Inchingolo, Raffaele Del Prete, Van Hung Pham, Sergey K. Aityan, Kieu C.D. Nguyen, Ciro Isacco Gargiulo

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; SARS-CoV-2; ZIKV; mRNA; RNAi; ncRNA; L1; retrotransposons; pluripotent multipotent stem cells

Online: 15 August 2023 (12:42:29 CEST)

Show abstract| Download PDF| Share

Coronavirus disease-2019 (COVID-19) was seen as a respiratory disease, however, an increasing number of reports indicated that the spike protein could also be the cause of the long-term post-infectious conditions known as Long-COVID characterized by a group of unresponsive idiopathic severe neuro, cardio-vascular disorders, including strokes, cardiopathies, neuralgias, fibromyalgia, and Parkinson's like-disease. Different lines of pieces of evidence confirmed that the spike protein that can be found on the surface of the SARS-CoV-2 virus latches onto angiotensin-converting enzyme 2 (ACE2) receptors located on target cells. The RNA genome of coronaviruses, which, has a median length of 29 kb and is the longest among all RNA viruses, is comprised of six to ten open reading frames (ORFs) that are responsible for encoding both the replicase and structural proteins for the virus. Each of the components of the viral genome is packaged into a helical nucleocapsid that is surrounded by a lipid bilayer. The viral envelope of coronaviruses is typically made up of three proteins that include the membrane protein (M), the envelope protein (E), and the spike protein (S). The spike protein not only facilitates the virus entry into healthy cells, which is the first step in infection but also promote profound damage to different organs and tissues leading to severe impairments and long-term disabilities. Here, we discussed the pervasive mechanism that spikes mRNA adopted to alter multipotent and pluripotent stem cell (SCs) genomes and the acquired disability of generating an infinite number of affected clonal cells. This stance is based on the molecular and evolutionary aspects obtained from retrotransposons-retrotransposition in mammalians and humans that documented the frequent integration of mRNA molecules into genomes and thus into DNA. Retrotransposition is the molecular process in which transcribed and spliced mRNAs are accidentally reverse-transcribed and inserted into new genomic positions to form a retrogene. Sequence-specific traits of mRNA clearly showed long interspersed element-1 (LINE-1 or L1) to confirm the retrotransposition, considered the most abundant autonomously active retrotransposons in the human genome. In mammals, L1 retrotransposons drive retrotransposition and are composed of long terminal repeats (LTRs) and non-LTR retrotransposons (mainly long interspersed nuclear elements or LINEs); specifically, the LTR-mediated retrocopies are immediately cotranscribed with their flanking LTR retrotransposons. In response to retrotransposons transposition, stem cells (SCs) employ a number of silencing mechanisms, such as DNA methylation and histone modification. This manuscript theorizes the expression patterns, functions, and regulation of mRNA Spike protein imprinted by SCs retrotransposons which generate unlimited lines of affected cell progenies and tissues as the main condition of untreatable Spike-related inflammatory conditions.

Preprint ARTICLE | doi:10.20944/preprints202308.0881.v1

Association of ABO Blood Type with Infection and Severity of COVID-19 in Inpatient and Longitudinal Cohorts

Tiffany Alyssa Eatz, Alejandro Max Antonio Mantero, Erin Caitlin Williams, Charles Joseph Cash, Nathalie Elisabeth Perez, Zachary James Cromar, Adiel Hernandez, Matthew Moses Cordova, Neha Pradyumna Godbole, Le Pham Anh, Rachel Rebecca Lin, Sherry Luo, Anmol Bharat Patel, Yaa Fosuah Abu, Suresh Pallikkuth, Savita G Pahwa

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: blood type; COVID-19; coronavirus; immunology; association; severity; infection A; O; B; AB; Rh factor

Online: 11 August 2023 (12:58:06 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Introduction: The objectives of this study were to (1) investigate the association between human blood type and COVID-19 infection in both inpatient and longitudinal populations at our institution in South Florida and (2) identify the association between blood type and severity of COVID-19 infection via presence of cellular biomarkers of severe infection in hospitalized individuals. Methods: This study consists of (1) a single-center retrospective analysis of 669 of 2,741 COVID-19 positive screened patients seen from January 1, 2020 until March 31, 2021 at the University of Miami Emergency Department (ED) who tested positive for COVID-19 infection and had a documented ABO blood type and (2) a longitudinal SARS-CoV-2 immunity study (“CITY”) at the University of Miami Miller School of Medicine consisting of 185 survey participants. COVID-19 outcome rates and 95% confidence intervals were calculated for each ABO blood type and Rh group using Chi-squared tests for categorical and ANOVA for continuous variables in the inpatient cohort and Chi-squared tests for the longitudinal cohort, all executed in R studio. Results: Our inpatient cohort had a mean age of 53.6 (± 17.9) years with 48% males and 52% females. When compared to patients with other blood types, those with O- demonstrated less risk of developing COVID-19 pneumonia (26.7% for O- vs. 69.2% for type A-, 56.5% for A+, 71.4% for AB+, 53.7% for B+, 51.5% for O+, p-value= 0.003 via Chi-squared test) and decreased mortality due to COVID-19 infection (17.0% mortality for O vs. 26.3% for A, 29.2% for B, p-value= 0.012 via Chi-squared test). Blood type O- demonstrated less elevated levels of LDH than did other blood types (p-value= 0.001, ANOVA) and a higher frequency of clinically accepted baseline levels of troponin (0.04 ng/mL) (p-value= 0.026, ANOVA) (Figure 1). Most of the longitudinal cohort was ABO blood grouping type O (47% (87/185)), with 33.5% type A, 14.1% B, and 5.4% AB. Most individuals were Rh positive (85.9%). There was no significant association found between COVID status (infection vs. non-infection) and ABO (Chi-squared test (3, N = 185) = 1.8, p = 0.6) or Rh (Chi-squared test (1, N = 185) = 0.16, p = 0.7) blood typing. Nearly all participants had been vaccinated (95.1% (176/185)), with a majority reporting primary vaccination with Pfizer (57.8% (107/185)), followed by Moderna (33% (61/185)), and Johnson & Johnson (4.3% (8/185)). 8 participants (4.3%) were unvaccinated. Conclusions: In an inpatient setting, blood type O sustained less risk of COVID-19 mortality and O- demonstrated less risk of developing COVID-19 pneumonia. In a longitudinal setting, there was no association found between blood type and COVID-19 severity. As the novelty of COVID-19 infection declines with time, further studies on risk-stratification by blood type are encouraged.

Preprint ARTICLE | doi:10.20944/preprints202307.1567.v1

Energy Consumption Forecasting in Commercial Buildings during the Covid-19 Pandemic: A Multivariate Multilayered Long-Short Term Memory Time-series Model with Knowledge Injection

Tan Ngoc Dinh, Gokul Sidarth Thirunavukkarasu, Mehdi Seyedmahmoudian, Saad Mekhilef, Alex Stojcevski

Subject: Engineering, Electrical And Electronic Engineering Keywords: Energy consumption prediction; Energy management; Time series forecasting; Building energy consumption forecast; Covid-19 pandemic

Online: 24 July 2023 (08:47:09 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202307.1532.v1

Molecular and Clinical Epidemiology of SARS-CoV-2 Infection Among Vaccinated and Unvaccinated Individuals in a Large Healthcare Organization from New Jersey

José R. Mediavilla, Tara Lozy, Annie Lee, Justine Kim, Veronica W. Kan, Elizabeth Titova, Ashish Amin, Michael Zody, André Corvelo, Dayna M. Oschwald, Amy Baldwin, Samantha Fennessey, Jerry M. Zuckerman, Thomas Kirn, Liang Chen, Yanan Zhao, Kar Fai Chow, Tom Maniatis, David S. Perlin, Barry N. Kreiswirth

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; COVID-19; pandemic; variants; RT-PCR; sequencing; surveillance; vaccination; vaccine breakthrough; comorbidity.

Online: 21 July 2023 (13:55:29 CEST)

Show abstract| Download PDF| Supplementary Files| Share

New Jersey was among the first states impacted by the COVID-19 pandemic, with one of the highest overall death rates in the nation. Nevertheless, relatively few reports have been published focusing specifically on New Jersey. Here we report on molecular, clinical, and epidemiologic observations from the largest healthcare network in the state, in a cohort of vaccinated and unvaccinated individuals with laboratory-confirmed SARS-CoV-2 infection. We conducted molecular surveillance of SARS-CoV-2-positive nasopharyngeal swabs collected in nine hospitals from December 2020 through June 2022, using both whole genome sequencing (WGS) and a real-time RT-PCR screening assay targeting spike protein mutations found in variants of concern (VOC) within our region. De-identified clinical data were obtained retrospectively, including demographics, COVID-19 vaccination status, ICU admission, ventilator support, mortality, and medical history. Statistical analyses were performed to identify associations between SARS-CoV-2 variants, vaccination status, clinical outcomes, and medical risk factors. A total of 5,007 SARS-CoV-2-positive nasopharyngeal swabs were successfully screened and/or sequenced. Variant screening identified three predominant VOC, including Alpha (n =714), Delta (n =1,877), and Omicron (n =1,802). Omicron isolates were further sub-typed as BA.1 (n =899), BA.2 (n =853), and BA.4/BA.5 (n =50); the remaining 614 isolates were classified as “Other”. Approximately 31.5% (1,577/5,007) of the samples were associated with vaccine breakthrough infections, which increased in frequency following the emergence of Delta and Omicron. Severe clinical outcomes included ICU admission (336/5007 = 6.7%), ventilator support (236/5007 = 4.7%), and mortality (430/5007 = 8.6%), with increasing age being the most significant contributor to each (p <0.001). Unvaccinated individuals accounted for 79.7% (268/336) of ICU admissions, 78.3% (185/236) of ventilator cases, and 74.4% (320/430) of deaths. Highly significant (p <0.001) increases in mortality were observed in individuals with cardiovascular disease, hypertension, cancer, diabetes, and hyperlipidemia, but not with obesity, thyroid disease, or respiratory disease. Significant differences (p <0.001) in clinical outcomes were also noted between SARS-CoV-2 variants, including Delta, Omicron BA.1, and Omicron BA.2. Vaccination was associated with significantly improved clinical outcomes in our study, despite an increase in breakthrough infections associated with waning immunity, greater antigenic variability, or both. Underlying comorbidities contributed significantly to mortality in both vaccinated and unvaccinated individuals, with increasing risk based on the total number of comorbidities. Real-time RT-PCR-based screening facilitated timely identification of predominant variants using a minimal number of spike protein mutations, with faster turnaround time and reduced cost compared to WGS. Continued evolution of SARS-CoV-2 variants will likely require ongoing surveillance for new VOCs, with real-time assessment of clinical impact.

Preprint ARTICLE | doi:10.20944/preprints202307.0775.v1

Modeling the Spatial Distribution of Different Strains of the COVID-19 Virus Based on the GeoSER(D) Model

Yaroslav Vyklyuk, Denys Nevinskyi, Valentyna Chopyak, Olga Golubovska, Kateryna Hazdiuk, Miroslav Škoda

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: multi-agent system; GEO-spatial simulation model; COVID-19; modelling; geo-object; real-time simulation

Online: 12 July 2023 (11:31:07 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202307.0507.v1

Genetic Predictors of Comorbid Course of COVID-19 and MAFLD: A Comprehensive Analysis

Mykhailo Buchynskyi, Valentyn Oksenych, Iryna Kamyshna, Sandor G. Vari, Aleksandr Kamyshnyi

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: MAFLD; COVID-19; NAFLD; SARS-CoV-2; PNPLA; rs738409; GCKR; rs780094; TM6SF2; rs58542926; LYPLAL1; rs12137855

Online: 7 July 2023 (15:42:56 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202306.0675.v1

A Different Perspective on SARS-Cov-2 Pandemic: Data, Outcomes and Demographic Analysis of a Study Conducted at General Hospital Ninh Thuan Province in Vietnam in 2022

Thach Huy Le, Mario G. Balzanelli, Thanh Van Le, Thang le Quoc, Dung Do Thuy, Pietro Distratis, Rita Lazzaro, Raffaele Del Prete, Francesco Triggiano, Ciro Isacco Gargiulo, Francesco Inchingolo, Vittoriana De Laurentiis, Luigi Santacroce, Kieu Cao Diem Nguyen

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: COVID-19; SARS-CoV-2; socio-demographic analysis; Ferritin; Lymphocytes; General hospital Ninh Thuan province

Online: 9 June 2023 (06:15:27 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202306.0542.v1

Geographical Factors Determining the Transmission of COVID-19: Lessons Learned from Turkish Black Sea Region to Face Next Pandemic Crisis

Aytac Perihan Akan, Mario Coccia

Subject: Social Sciences, Other Keywords: COVID-19; Coronavirus Disease; SARS-CoV-2; Humidity; Rainfall; Coastal regions; Pandemic plans; Health Policy

Online: 7 June 2023 (11:03:07 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202306.0170.v1

Vascular Dysfunctions Contribute to the Long-term Cognitive Deficits Following COVID-19

zahra shabani, Jialing Liu, hua su

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Long-COVID-19; SARS-CoV-2; Endothelial cells; Cognitive dysfunction; Blood Brain Barrier; Neuro-inflammation

Online: 2 June 2023 (09:38:56 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202305.0822.v1

Exploring the Impact of Herbal Therapies on COVID-19 and Influenza: Investigating Novel Delivery Mechanisms for Emerging Interventions

Lucas Fornari Laurindo, Ledyane Taynara Marton, Giulia Minniti, Victoria Dogani Rodrigues, Rodrigo Buzinaro Suzuki, Virgínia Maria Cavallari Strozze Catharin, Rakesh Kumar Joshi, Sandra Maria Barbalho

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: Medicinal plants; antiviral; SARS-CoV-2; COVID-19; Influenza; Delivery systems; Nanomedicine; Nanocarriers; Antiviral therapies

Online: 11 May 2023 (08:30:22 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202305.0403.v1

SARS-CoV-2 in the Middle Ear. CovEar: A Prospective Pilot Study

Nina Rubicz, Nikolaus Poier-Fabian, Christian Paar, Markus Winkler-Zamani, Philipp Hermann, Stefan Raidl, Paul Martin Zwittag

Subject: Medicine And Pharmacology, Otolaryngology Keywords: COVID-19; Coronavirus; SARS-CoV-2; middle ear; ear surgery; middle ear surgery; otologic surgery

Online: 6 May 2023 (09:34:27 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202305.0218.v1

Vaccinia Virus Strain Mva Expressing a Prefusion-Stabilized SARS-CoV-2 Spike Glycoprotein Induces Robust Protection and Prevents Brain Infection in Mouse and Hamster Models

María M Lorenzo, Alejandro Marín-López, Kevin Chiem, Luis Jimenez-Cabello, Irfan Ullah, Sergio Utrilla-Trigo, Eva Calvo-Pinilla, Gema Lorenzo, Sandra Moreno, Chengjin Ye, Jun-Gyu Park, Alejandro Matía, Alejandro Brun, Juana M Sánchez-Puig, Aitor Nogales, Walther Mothes, Pradeep D Uchil, Priti Kumar, Javier Ortego, Erol Fikrig, Luis Martinez-Sobrido, Rafael Blasco

Subject: Biology And Life Sciences, Virology Keywords: Poxvirus; Modified Vaccinia virus Ankara; vaccine; SARS-CoV-2; COVID-19; recombinant viral vectors; immunization

Online: 4 May 2023 (07:48:34 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202305.0089.v1

COVID-19 Vaccine Acceptance and Hesitancy among University Community members in Otukpo, Nigeria: A Cross-Sectional Study

Suleiman Zakari, Celestine O. Ogbu, Hajara Zakari, Chioma Eze Sabina, Samuel Bawa Ijimbili, Jennifer Ene Idoko, Andrew Oche Emmanuel, Amuji Doris Nnenna, Bright Chiaka Agbwara, Efere Sarah Adokiye, Ayodeji Oluwafemi Idowu, Ovie Austine Edegbene, Joseph Anejo-Okopi

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Acceptance; COVID-19; Cross-sectional study; Federal University of Health Sciences Otukpo; Vaccine hesitancy; Nigeria

Online: 3 May 2023 (02:51:50 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202305.0077.v1

SARS Cov2 Infection and Preeclampsia. How an Infection Can Help Us To Know More About an Obstetric Condition

Otilia Gonzalez, Oscar Martinez-Perez

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: SARS- Cov-2; Covid 19; Preclampsia; pregnancy; hypertensive disorders of pregnancy; inflammation; cytokines; throm-botic

Online: 2 May 2023 (10:07:10 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202304.0961.v1

Whole Genome Sequence Analysis of SARS-COV-2 Isolated from COVID-19 Patients in Duhok Province, Iraq

Sherzad Majeed Taher, Jassim Mohammed Abdo, Muayad Aghali Merza

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: COVID-19 patient; whole Genome sequence; Of SARS-COV-2; phylogenetic analysis and Transmission supported

Online: 26 April 2023 (05:15:36 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202303.0325.v1

Cardiovascular Safety of Hydroxychloroquine-Azithromycin in 424 COVID-19 Patients

Matthieu Million, Jean-Christophe Lagier, Jérôme Hourdain, Frédéric Franceschi, Jean-Claude Deharo, Philippe Parola, Philippe Brouqui

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; SARS-CoV-2; hydroxychloroquine; azithromycin; QTc interval; cardiac rhythm; safety; torsades de pointe

Online: 17 March 2023 (11:34:00 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202302.0108.v1

Effects of Health Anxiety, Social Support, and Coping on Dis-sociation with Mediating Role of Perceived Stress during the COVID-19 Pandemic

László Róbert Kolozsvári, Viktor Rekenyi, Szabolcs Garbóczy, Ágnes Hőgye-Nagy, Anita Szemán-Nagy, Mohamed Sayed-Ahmad, Katalin Héjja-Nagy

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: perceived stress; social support; health anxitety; coping; lockdown; COVID-19; international stu-dents; domestic students

Online: 7 February 2023 (02:22:04 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202212.0234.v1

History of Advances in Genetic Engineering of Viruses Prior to COVID-19 Pandemic

Mikhail Teppone

Subject: Biology And Life Sciences, Virology Keywords: reassortant virus; recombinant virus; chimeric virus; genetic engineering; reverse genetic; SARS-CoV-2; COVID-19

Online: 13 December 2022 (08:47:51 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202211.0448.v1

COVID-19 Pathology Sheds New Light on Balance between Neutrophil Proteases and Their Inhibitors

Marko Radic, Vasuki Vindiya Silva

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: alpha-1-antitrypsin (AAT); neutrophil elastase (NE); NETosis, PAD4, ARDS, COPD; neutrophils; COVID-19; TMPRSS2.

Online: 24 November 2022 (02:50:25 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202211.0240.v1

Pre-Service University Training, Body Expression and Self-Concept

M. Rosario Romero-Martín, Daniel Caballero-Juliá

Subject: Social Sciences, Education Keywords: body expression; self-concept; pre-service training; physical activity; physical education; COVID-19 pandemic; emotions

Online: 14 November 2022 (06:23:17 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202209.0268.v1

Impact of COVID-19 Lockdowns on the Activity and Mental Health of Older People in Indonesia: A Qualitative Study

Nelsensius Klau Fauk, Ernawati Ernawati, Elsa Dent, Gregorius Abanit Asa, Paul Russell Ward

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19 outbreak; lockdown protocols; individual and social activities; mental health challenges; older people; Indonesia

Online: 19 September 2022 (07:51:50 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202209.0068.v1

Global Impact of COVID-19 Pandemic on Physical Activity Habits of Competitive Runners: an Analysis of Wearable Device Data

Julia Lee Romero, Qin Lv

Subject: Computer Science And Mathematics, Analysis Keywords: wearable device; physical activity; behavior; COVID-19; pandemic; exercise habits; analysis; objectively-measured physical activity

Online: 5 September 2022 (13:49:56 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202207.0447.v1

Impact of COVID-19 Pandemic on School-aged Children’s Physical Activity, Screen Time and Sleep in Hong Kong: a Cross-sectional Repeated Measures Study

Hung-Kwan So, Gilbert T Chua, Ka-Man Yip, Keith TS Tung, Rosa S Wong, Lobo HT Louie, Winnie WY Tso, Ian Wong, Jason Yam, Mike Kwan, Gary KK Lau, Judy Kong, Wilfred HS Wong, Patrick Ip

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: COVID-19 pandemic; school closures; school-aged children; physical activity; screen time; sleep; Hong Kong

Online: 29 July 2022 (03:57:32 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202206.0230.v1

How the First Year of the COVID-19 Pandemic Impacted Patients’ Care in the Vascular Surgery Divisions of the Southern Regions of the Italian Peninsula

Eugenio Martelli, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Sangiorgi, Matilde Zamboni, Allegra Rosa Martelli, Giancarlo Accarino, Giuseppe Bianco, Francesco Bonanno, Umberto Marcello Bracale, Enrico Cappello, Giovanni Cioffi, Giovanni Colacchio, Adolfo Crinisio, Salvatore De Vivo, Carlo Patrizio Dionisi, Loris Flora, Giovanni Impedovo, Francesco Intrieri, Luca Iorio, Gabriele Maritati, Piero Modugno, Mario Monaco, Giuseppe Natalicchio, Vincenzo Palazzo, Fernando Petrosino, Francesco Pompeo, Raffaele Pulli, Davide Razzano, Maurizio Ruggero Ruggieri, Carlo Ruotolo, Paolo Sangiuolo, Gennaro Vigliotti, Pietro Volpe, Antonella Biello, Pietro Boggia, Michelangelo Boschetti, Enrico Maria Centritto, Flavia Condò, Lucia Cucciolillo, Amodio Salvatore D'Amodio, Mario De Laurentis, Claudio Desantis, Daniela Di Lella, Giovanni Di Nardo, Angelo Disabato, Ilaria Ficarelli, Angelo Gasparre, Antonio Nicola Giordano, Alessandro Luongo, Mafalda Massara, Vincenzo Molinari, Andrea Padricelli, Marco Panagrosso, Anna Petrone, Serena Pisanello, Roberto Prunella, Michele Tedesco, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: COVID-19; carotid stenosis; abdominal aortic aneurysm; chronic limb-threatening ischemia; amputation; deep venous thrombosis

Online: 16 June 2022 (04:40:54 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202205.0211.v1

Developing New Teaching Materials to Enhance Students Learning and Engagement at University

Emilia María Carmona Calero, Juan Manuel González Toledo, Germán F. Rodríguez Lobato, Héctor de Paz Carmona, Agustín Castañeyra Perdomo

Subject: Social Sciences, Education Keywords: COVID-19; active learning; science learning; applied technology, assessment for learning; new teaching material development

Online: 16 May 2022 (13:13:32 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202203.0375.v1

Rapid Detection of Anti-SARS-CoV-2 Antibodies With a Screen-Printed Electrode Modified With a Spike Glycoprotein Epitope

Wiilson Ameku, David Provance, Carlos Morel, Salvatore De-Simone

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; COVID-19; spike glycoprotein; epitope; electrochemical biosensor; point of care; immunological diagnostic

Online: 29 March 2022 (08:39:31 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202203.0040.v1

Augmented Sensitivity of At-Home Rapid SARS-CoV-2 Antigen Test (RAT) Kits with Computer Vision

Kim Miikki, Lars Miikki, Jenny Wiklund, Alp Karakoç

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; rapid antigen test; RT-PCR test; COVID-19; image processing; Raspberry Pi

Online: 2 March 2022 (08:06:49 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202202.0224.v1

Omicron Variant: Secrets Behind the Great Escape Artist

Henry Sutanto, Djoko Santoso

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; pandemic; SARS-CoV-2; Omicron variant; emerging disease; global health; virus; genome; mutation

Online: 18 February 2022 (05:23:18 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202112.0038.v1

Changes in the Lifestyle in Spanish University Population during the Confinement for COVID-19

Sandra Sumalla-Cano, Tamara Forbes-Hernández, Silvia Aparicio-Obregón, Jorge Crespo, Maria Eléxpuru-Zabaleta, Monica Gracia-Villar, Francesca Giampieri, Iñaki Elío

Subject: Biology And Life Sciences, Behavioral Sciences Keywords: COVID-19; eating habits; physical activity; MEDAS-14; Emotional eating questionnaire (EEQ) and university population.

Online: 2 December 2021 (12:52:17 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202109.0216.v2

Analysing Discussions Around Rural Health on Twitter During the COVID-19 Pandemic

Wasim Ahmed, Josep Vidal-Alaball, Josep Maria Vilaseca Llobet

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Rural Health; Twitter Messaging; Social Media; Covid-19, SARS-CoV-2; coronavirus; social network analysis

Online: 19 November 2021 (14:41:47 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202106.0667.v1

Air Quality in the Italian Northwestern Alps during Year 2020: Assessment of the COVID-19 «Lockdown Effect» from Multi-Technique Observations and Models

Henri Diémoz, Tiziana Magri, Giordano Pession, Claudia Tarricone, Ivan Karl Friedrich Tombolato, Gabriele Fasano, Manuela Zublena

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: COVID-19; air quality; nitrogen oxides; ozone; aerosol; source apportionment; aerosol profiles; models; Alps; Italy

Online: 28 June 2021 (14:37:17 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202106.0060.v1

COVID-19: Unmasking Emerging SARS-CoV-2 Variants, Vaccines and Therapeutic Strategies

Renuka Raman, Krishna J. Patel, Kishu Ranjan

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: SARS-CoV-2; COVID-19; variants; vaccines; immune dysregulated; comorbidities; antibody; Spike protein; biomolecules; coronavirus

Online: 2 June 2021 (09:56:14 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202105.0452.v1

Globalization, Inequality, Environmental Damage and the Corona Pandemic - Lessons for Economic, Environmental and Social Policy

Bianca Blum, Bernhard Karl Justus Neumärker

Subject: Business, Economics And Management, Accounting And Taxation Keywords: corona; covid-19; crisis management; basic income; environmental politics; globalization; public policy; inequality; sustainable development

Online: 19 May 2021 (14:38:12 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202105.0447.v1

Public Perceptions about COVID-19 Vaccines: Policy Implications from US Spatiotemporal Sentiment Analytics

G. G. Md. Nawaz Ali, Md. Mokhlesur Rahman, Md. Amjad Hossain, Md. Shahinoor Rahman, Kamal Chandra Paul, Jean-Claude Thill, Jim Samuel

Subject: Public Health And Healthcare, Health Policy And Services Keywords: Vaccine; Sentiment analysis; Public Sentiment Scenarios framework; COVID-19; Coronavirus; Twitter; Textual analytics; Public policy

Online: 19 May 2021 (13:51:57 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202105.0030.v1

Application of Telehealth in Prenatal Care During the COVID-19 Pandemic - A Cross-Sectional Survey of Polish Women

Dominik Jakubowski, Dorota Sys, Anna Kajdy, Roksana Lewandowska, Ewa Kwiatkowska, Aneta Cymbaluk-Płoska, Michał Rabijewski, Andrzej Torbé, Sebastian Kwiatkowski

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: SARS-CoV-2; COVID-19; Prenatal Care; Standard of Care; Telemedicine; Cross-Sectional Studies; Poland

Online: 5 May 2021 (10:32:26 CEST)

Show abstract| Download PDF| Share

Working Paper ARTICLE

Uneven Use of Remote Work to Prevent the Spread of COVID-19 in South Korea’s Stratified Labor Market

Joonmo Cho, Sanghee Lee, Saejung Park

Subject: Business, Economics And Management, Economics Keywords: COVID-19; remote work; dual labor market; polarization; collective bargaining; rule revision unfavorably to workers

Online: 27 April 2021 (10:12:27 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202104.0656.v1

Modeling the Impact of a Coronavirus Vaccine Among Low and High Risk Populations in the United States

Rachel Ruffin, Ariana Richardson, Enahoro A Iboi

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: COVID-19; non-pharmaceutical interventions; vaccinations; vaccine doses; pre-existing condition; high risk; low risk

Online: 26 April 2021 (11:00:59 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202104.0469.v1

How Do Enveloped Viruses Exploit the Secretory Proprotein Convertases to Regulate Infectivity and Spread?

Nabil G Seidah, Antonella Pasquato, Ursula Andreo

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Enveloped Virus; Proprotein Convertases; Furin; SKI-1/S1P; PCSK9; SARS-CoV-2; COVID-19; Pandemic

Online: 19 April 2021 (12:06:22 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202011.0532.v2

COVID-19 Lockdown and Lifestyles – A Narrative Review

Sathyanarayanan Doraiswamy, Sohaila Cheema, Ahmad Al Mulla, Ravinder Mamtani

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; Lifestyle; Diet; Physical activity; Stress; Smoking; Substance; Alcohol; Emotional well-being; Social connectedness

Online: 15 March 2021 (13:39:05 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202103.0097.v1

Community Health Workers as a Strategy to Tackle Psychosocial Suffering due to Physical Distancing: A Randomized Controlled Trial

Dorien Vanden Bossche, Susan Lagaert, Sara Willems, Peter Decat

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Community health workers; Primary healthcare; Mental health; Psychosocial support; Vulnerable populations; COVID-19; Health crisis

Online: 2 March 2021 (14:31:40 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202102.0518.v1

Next City: Learning from Cities During COVID-19 to Tackle Climate Change

Christina Kakderi, Nicos Komninos, Anastasia Panori, Eleni Oikonomaki

Subject: Business, Economics And Management, Accounting And Taxation Keywords: smart cities; health crisis; COVID-19; pandemics; intelligent ecosystems; connected intelligence; environmental sustainability; climate change

Online: 23 February 2021 (14:18:15 CET)

Show abstract| Download PDF| Share

Working Paper ARTICLE

Cultivating Quality Awareness in Corona Times

Guus Timmerman, Andries Baart, Jan den Bakker

Subject: Social Sciences, Anthropology Keywords: quality of care; Covid-19; relational caring; care ethics; practical wisdom; mismatch; humanness; solicitude; habitability

Online: 28 January 2021 (12:45:14 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202101.0473.v1

Summarize of the Available Molecular Methods for Detection of Sars-Cov-2 During the Ongoing Pandemic

Fabio Arena, Simona Pollini, Gian Maria Rossolini, Maurizio Margaglione

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: molecular methods; virus; pandemic; Coronaviridae; COVID-19, diagnosis; UK variant; B.1.1.7 variant; 501Y.V2 variant

Online: 25 January 2021 (10:32:38 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202101.0404.v1

A Low-Cost Air Flow Sensor/Transducer for Medical Applications: Design and Experimental Characterization

Jesús Calderón, Carlos Rincón, Bray Agreda, Sebastián Calero, Manuel Bornas, Juan José Jiménez de Cisneros

Subject: Engineering, Automotive Engineering Keywords: air flow medical sensor; emergency air flow sensor; low-cost air flow sensor; COVID-19

Online: 20 January 2021 (16:14:23 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202012.0624.v1

A Bibliometric Analysis of COVID-19 Research

Yuh-Shan Ho, Andrea Gatto

Subject: Social Sciences, Library And Information Sciences Keywords: COVID-19; SARS-CoV-2; Coronavirus; Bibliometrics; Outbreak; pandemic; Web of Science Core Collection; WoS

Online: 24 December 2020 (13:34:07 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202011.0698.v1

Emergency Online Learning in Low-Resource Contexts: Student Perceptions of Effective Engagement Strategies

Victoria Abou-Khalil, Samar Helou, Eliane Khalifé, MeiRong Alice Chen, Rwitajit Majumdar, Hiroaki Ogata

Subject: Social Sciences, Education Keywords: online learning; emergency; low-resource; engagement; distance learning; student perception; survey; COVID-19; Moore framework

Online: 27 November 2020 (15:19:57 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202011.0558.v1

Recombinant Protein Vaccines, a Proven Approach Against Coronavirus Pandemics

Jeroen Pollet, Wen-Hsiang Chen, Ulrich Strych

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; COVID-19; Adjuvants; Vaccine Production; Vaccine Delivery; Clinical Trials; Neutralizing Antibodies; Th1

Online: 22 November 2020 (11:57:51 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202011.0362.v1

Tackling COVID-19 Pandemic through Research in Latin America and the Caribbean: A Bibliometric Analysis

Isabel Espinosa, Victor Cuenca, Ahmed Eissa-Garcés, Ivan Sisa

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Health research policy; National health research system; COVID-19; Biomedical Research; Latin America and Caribbean

Online: 13 November 2020 (07:09:52 CET)

Show abstract| Download PDF| Share

Working Paper ARTICLE

Coronavirus and Halal Tourism and Hospitality Industry: Is It a Journey to the Unknown?

Hatem El-Gohary

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Coronavirus; COVID-19; Halal hospitality; Halal tourism; tourism industry; Muslim travellers; KSA; Egypt; Middle East

Online: 9 November 2020 (10:07:11 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202010.0290.v1

Rapid COVID-19 Diagnosis Using Deep Learning of the Computerized Tomography Scans

Hamed Tabrizchi, Amir Mosavi, Akos Szabo-Gali, Laszlo Nadai

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: COVID-19; image-based diagnosis; artificial intelligence; machine learning; deep learning; computerized tomography; coronavirus disease

Online: 14 October 2020 (09:07:51 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202008.0620.v2

Parks are Critical Urban Infrastructure: Perception and Use of Urban Green Spaces in NYC During COVID-19

Bianca Lopez, Christopher Kennedy, Timon McPhearson

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Urban green space; COVID-19; urban parks; open space; New York City; urban infrastructure; equity

Online: 30 September 2020 (10:00:40 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202009.0657.v1

Test@Work Texts: Mobile Phone Messaging to Increase Awareness of HIV and HIV Testing in UK Construction Employees During the COVID-19 Pandemic

Matthew Middleton, Sarah Somerset, Catrin Evans, Holly Blake

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: HIV; workplace intervention; SMS; HIV testing; construction; mobile phone; Covid-19; health promotion; text messaging

Online: 27 September 2020 (03:02:41 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Background: HIV poses a threat to global health. With effective treatment options available, education and testing strategies are essential in preventing transmission. Text messaging is an effective tool for health promotion and can be used to target higher risk populations. This study reports on the design, delivery and testing of a mobile text messaging SMS intervention for HIV prevention and awareness, aimed at adults in the construction industry and delivered during the COVID-19 pandemic. Method: Participants were recruited at Test@Work workplace health promotion events (21 sites, n=464 employees), including health checks with HIV testing. Message development was based on a participatory design and included a focus group (n=9) and message fidelity testing (n=291) with assessment of intervention uptake, reach, acceptability, and engagement. Barriers to HIV testing were identified and mapped to the COM-B behavioural model. 23 one-way push SMS messages (19 included short web links) were generated and fidelity tested, then sent via automated SMS to two employee cohorts over a 10-week period during the COVID-19 pandemic. Engagement metrics measured were; opt-outs, SMS delivered/read, number of clicks per web link, and four two-way pull messages exploring repeat HIV testing, learning new information, perceived usefulness and behaviour change. Results: 291 people participated (68.3% of eligible attendees). A total of 7,726 messages were sent between March and June 2020, with 91.6% successfully delivered (100% read). 12.4% of participants opted out over 10 weeks. Of delivered messages, links were clicked an average of 14.4%, max 24.1% for HIV related links. The number of clicks on web links declined over time (r= -6.24, p=0.01). Response rate for two-way pull messages was 13.7% of participants. Since the workplace HIV test offer at recruitment, 21.6% reported having taken a further HIV test. Qualitative replies indicated behavioural influence of messaging on exercise, lifestyle behaviours and intention to HIV test. Conclusion: SMS messaging for HIV prevention and awareness is acceptable to adults in the construction industry, has high uptake, low attrition and good engagement with message content, when delivered during a global pandemic. Data collection methods may need refinement for audience and effect of COVID-19 on results is yet to be understood.

Preprint REVIEW | doi:10.20944/preprints202009.0420.v1

SARS-CoV-2 S Protein Binding hACE2: Viral Entry, Pathogenesis, Prognosis, and Potential Therapeutic Targets

Lobna Al-Zaidan, Sarra Mestiri, Afsheen Raza, Maysaloun Merhi, Varghese Inchakalody, Queenie Fernandez, Nassiba Taib, Shahab Uddin, Said Dermime

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: COVID-19; SARS-CoV-2; ACE2 receptor; spike glycoprotein; S glycoprotein immunogenic sequences; ACE2 polymorphism

Online: 18 September 2020 (04:56:02 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202009.0058.v1

Animal Reservoirs and Hosts for Emerging Alpha- and Betacoronaviruses

Ria Ghai, Ann Carpenter, Meghan Herring, Krystalyn Martin, Susan Gerber, Aron Hall, Amanda Liew, Jonathan Sleeman, Sophie VonDobschuetz, Casey Barton Behravesh

Subject: Biology And Life Sciences, Virology Keywords: Emerging infectious diseases; coronaviruses; COVID-19; SARS-CoV; SARS-CoV-2; MERS-CoV; zoonotic diseases

Online: 3 September 2020 (04:54:38 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202008.0320.v1

Data Science in Unveiling COVID-19 Pathogenesis and Diagnosis: Evolutionary Origin to Drug Repurposing

Jayanta Kumar Das, Giuseppe Tradigo, Pierangelo Veltri, Pietro H Guzzi, Swarup Roy

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Data Science; Machine Learning; Deep Learning; Genomics; COVID-19; Drug Discovery; Image Analysis; Interactomics; Epidemiology

Online: 14 August 2020 (11:01:56 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202008.0246.v2

Impacts of the COVID-19 Pandemic on Life of Higher Education Students: A Global Perspective

Aleksander Aristovnik, Damijana Keržič, Dejan Ravšelj, Nina Tomaževič, Lan Umek

Subject: Social Sciences, Education Keywords: COVID-19; university student; socio-demographic factors, satisfaction; perception; online learning; mental health; habits; institutions; continents

Online: 19 August 2020 (08:20:09 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202005.0463.v2

Trends of Mutation Accumulation across Global SARS-CoV-2 Genomes: Implications for the Ecology and Evolution of the Novel Coronavirus

Chayan Roy, Santi M Mandal, Suresh K Mondol, Shriparna Mukherjee, Wriddhiman Ghosh, Ranadhir Chakraborty

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; COVID-19; genome-wide mutations; transition and transversion; microevolution; disinfectants as mutagens

Online: 30 July 2020 (06:22:00 CEST)

Show abstract| Download PDF| Supplementary Files| Share

The all-pervasiveness and dynamic nature of the COVID-19 pandemic warrants comprehensive and constant surveillance of the numerous mutations that are accumulating in global SARS-CoV-2 genomes and contributing to the microevoution of the various lineages of the novel coronavirus. This would help us gain insights into the evolving pathogenicity of the virus, and thereby improvise our control and therapeutic strategies. This study explores the genome-wide frequency, gene-wise distribution, and molecular nature, of the large repertoire of point mutations detected across the global dataset of 3,608 SARS-CoV-2 RNA-genomes short-listed from a total 5,485 whole genome sequences deposited in GenBank till 4 June 2020 using a download filter that eliminated all incomplete/gapped sequences. Phylogenomic analysis involving all existing SARS-CoV-2 lineages, represented by 3,740 whole genome sequences from human-source (out of a total of 63,894 sequences stored in the GISAID repository, as on 15 July, 2020), illustrated that the two major-lineages of the virus contributed almost equivalently to the pandemic. However, entities belonging to the early lineages are still mostly spread over Asian countries, whereas those affiliated to recently-derived lineages have a relatively more global distribution. Mutation frequency in the SARS-CoV-2 pan genome was found to be 2.27 × 10^-5 nucleotide positions mutated per nucleotide analyzed. An overwhelming majority (count: 1797) of the total 2452 instances of single nucleotide substitution detected (in the SARS-CoV-2 pan genome) were found to be transition mutations with cytidine to uridine (CàU) as the most ubiquitous molecular-type (count: 987). Of the 655 instances of transversion detected, the guanosine to uridine (GàU) variant was most widespread (count: 367). All transcribed and untranscribed loci of the pan genome were found to contain mutation(s). nsp3, and S, N and orf3a, were the most point-mutation-ridden non-structural and structural protein-coding genes, respectively, with 435, 300, 171 and 128 total mutations; 349/86, 192/108, 107/64 and 76/52 transitions/transversions; and 189/48, 106/55, 59/42 and 43/31 CàU/GàU substitutions respectively. Potential mechanistic backgrounds were envisaged for the molecular bias of mutations observed in SARS-CoV-2.

Preprint ARTICLE | doi:10.20944/preprints202007.0306.v1

Study the Trend Pattern in COVID-19 using Spline-Based Time Series Model: A Bayesian Paradigm

Varun Agiwal, Jitendra Kumar, Yau Chun Yip

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: COVID-19; Linear and non-Linear trend; Spline function; Autoregressive Time series model; Bayesian inference

Online: 14 July 2020 (11:41:59 CEST)

Show abstract| Download PDF| Share

Preprint COMMUNICATION | doi:10.20944/preprints202007.0012.v1

Coronavirus and Football (Soccer): Why Mid-Day Matches Are Much Safer for Players

Nadav Kashtan, Aliza Fedorenko, Tomer Orevi

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: COVID-19; football; soccer; microbiology; microdroplets; saliva; SARS-CoV-2, sport; soccer; surfaces; transmission; viruses

Online: 3 July 2020 (05:13:30 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202006.0369.v1

Temperature Extreme May Exaggerate the Mortality Risk of COVID-19 in the Low- and Middle-income Countries: A Global Analysis

Mizanur Rahman, Mahmuda Islam, Mehedi Hasan Shimanto, Jannatul Ferdous, Abdullah Al-Nur Shanto Rahman, Pabitra Singha Sagor, Tahasina Chowdhury

Subject: Biology And Life Sciences, Biophysics Keywords: temperature extreme; warm climate; low-and middle-income economies; COVID-19; mortality; mixed effect modelling

Online: 30 June 2020 (11:38:15 CEST)

Show abstract| Download PDF| Share

Working Paper BRIEF REPORT

A Report from COVID-19 Italian Epicentre: LODI Hospital Experience in Healthcare Workers Protection

Alessandro Baracco, Vittorio Beccarini, Andrea Filippin, Davide Bosio, Gabriele Perotti, Massimo Lombardo

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: SARS‐CoV‐2; CoVID-19; healthcare workers; HCWs protection; Lodi; infection prevention and control strategies

Online: 26 May 2020 (08:25:05 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202005.0372.v1

Modeling and Analysis of The Early-Growth Dynamics of COVID-19 Transmission

Abul Kalam al Azad, Asif Mostafa Hussain

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: COVID-19; SARS-CoV-2; Coronavirus; Pandemic; Epidemiological Analysis; Exponential Growth; Herd Immunity; Doubling Period

Online: 23 May 2020 (10:36:33 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202005.0338.v1

Community Pharmacy Response to Infection Control during COVID-19. A Cross-Sectional Survey.

Zachary Sum, Charmane Ow

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: pharmacy practice; infection control; sanitation; COVID-19; SARS-CoV-2; pharmacists; public health; workplace safety

Online: 21 May 2020 (08:37:52 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Background: Australia received its first case of coronavirus on 25 January 2020. Since then the demands of COVID-19 has presented unparalleled levels of strain on the public healthcare systems in the country. In this time of crisis, pharmacists and community pharmacy staff have modified work strategies according to the rapidly changing environment. With a delayed dissemination of resources and guidelines, pharmacist and pharmacies are practicing innovative infection control methods across Australia to protect their staff, patients and the community. This article seeks to explore the current activities undertaken by pharmacists in various community pharmacy settings across Australia in relation to the safety of the workplace environments for staff and patients. Information collected can help inform future decisions in pandemic preparation for pharmacies in response to similar health crisis now and in the future. Methods: An online cross-sectional survey study was conducted in Australia during the COVID-19 outbreak from 1^st to 30^th April 2020. The questionnaire addressed community pharmacist’s awareness and response to infection and sanitation control. Results: A total of 137 pharmacists took part in the survey, with almost half (45.26%) belonging to the age group of 25 to 34 years. Community pharmacy formed the bulk (89.05%) of the respondent’s primary place of practice. There was a good uptake of safety measures by pharmacists and their pharmacies to protect staff and patients. However the task of reassigning high health risk staff was not heavily practiced (34.31%). Regular cleaning took place in the pharmacy, but the use of gloves while cleaning was not practiced in 48.18% of respondents. In addition, only 46.72% of respondents reported observing script baskets being cleaned and disinfected. About one-third (37.96%) of pharmacists were aware of the two-step cleaning and disinfecting process, but only 18.98% of pharmacists reported observing or performing this sanitation procedure. More than half of surveyed pharmacists reported having difficulty keeping up with infection control changes and pharmacy practice guidelines during the pandemic. Conclusion: This study demonstrates that the majority of pharmacists are not fully aware of the infection control measures needed in a community pharmacy setting. The influx of coronavirus updates has made it difficult for pharmacists to implement accurate procedures on some aspects of workplace hygiene, which may have led to some gaps in infection control measures. Pharmacists must aim to uphold their public health ambassador role and aim to keep up-to-date with professional guidance to provide the necessary infection control measures to ensure staff, patient and public health safety.

Preprint SHORT NOTE | doi:10.20944/preprints202005.0287.v1

The Impacts of COVID-19 to Small Scale Fisheries in Tun Mustapha Park, Sabah, Malaysia; What Do We Know So Far?

Joannie Jomitol, Adam J. Payne, Sarmalin Sakirun, Mohd. Omar Bural

Subject: Biology And Life Sciences, Aquatic Science Keywords: COVID-19; small scale fisheries; artisarnal fishers; coastal communities; marine protected area; Malaysia; fisheries; impacts

Online: 17 May 2020 (08:46:10 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202005.0266.v1

Analysis of the COVID-19 Pandemic Spreading in India by an Epidemiological Model and Fractional Differential Operator

Amjad S. Shaikh, Vikas S. Jadhav, Munir G. Timol, Kottakkaran S. Nisar, I. Khan

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: compartmental model; COVID-19; modified Riemann Liouville fractional differential operator; basic reproduction number; numerical simulations

Online: 16 May 2020 (16:16:14 CEST)

Show abstract| Download PDF| Share

Preprint CONCEPT PAPER | doi:10.20944/preprints202005.0137.v1

COVID-19 Management in Spain. Errors to Avoid and the Need of A Post-Confinement Longitudinal Epidemiological Study

Rafael Franco

Subject: Public Health And Healthcare, Health Policy And Services Keywords: COVID-19; SARS-CoV-2; pandemic; ethics; public health; longitudinal clinical trial; silent virus carrier

Online: 8 May 2020 (07:53:54 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202005.0090.v1

The SIR and SEIR Epidemiological Models Revisited

John P. Maassen

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: epidemiological model; basic reproduction number; SIR; SEIR; COVID-19; stochas-tic model; Monte-Carlo simulation

Online: 6 May 2020 (03:15:02 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202004.0040.v3

COVID-19 Virus Infection and Transmission are Observably Less in Highly Dengue-endemic Countries: Can Dengue Vaccines be “Repurposed” to Prevent COVID-19?

Subhajit Biswas, Soumi Sukla

Subject: Biology And Life Sciences, Virology Keywords: Dengue; COVID-19; SARS-CoV-2; epidemiology; infection; mortality; cross-protection; Dengue vaccine; ELISA; Dengvaxia

Online: 5 May 2020 (03:00:34 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202004.0526.v1

A snapshot on COVID-19: A review

Mahfuz Al Mamun, Kaiissar Mannoor, Tahmina Shirin, Meerjady Sabrina Flora, Firdausi Qadri, Lili Ren, Jianwei Wang

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; SARS-CoV-2; origin; transmission; epidemiology; signs and symptoms; diagnosis; treatment and prevention.

Online: 30 April 2020 (10:47:14 CEST)

Show abstract| Download PDF| Share

Working Paper REVIEW

Renin-Angiotensin-Aldosterone System: Double-Edged Sword in COVID-19 Infection

Jana Burchfield

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: COVID-19; SARS-CoV; SARS-CoV-2; Angiotensin-converting enzyme 2; renin-angiotensin-aldosterone system

Online: 25 March 2020 (03:56:27 CET)

Show abstract| Download PDF| Share

The role of the Renin-Angiotensin-Aldosterone System (RAAS) in Corona Virus Disease 2019 (COVID-19) infection has become a controversial topic of discussion. RAAS inhibitors, such as Angiotensin Converting Enzyme (ACE) inhibitors and Angiotensin II receptor blockers (ARBs), which are used to treat cardiovascular diseases, have been implicated in potentially increasing cell surface levels of ACE2. ACE2 is the host receptor for COVID-19 that was discovered in Wuhan, China in December 2019. Since December, COVID-19 has transmitted rapidly across the world and has become a global pandemic. COVID-19 is similar to the Middle East respiratory syndrome coronavirus (MERS-CoV) with the first case reported in Saudi Arabia in September 2012. COVID-19, also known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is also similar to SARS-CoV, which first infected humans in the Guangdong province of southern China in 2002, and caused an epidemic between November 2002 and July 2003. Both SARS-CoV and COVID-19 use ACE2 to enter host cells. ACE2 is primarily expressed in the mouth, lung, heart, esophagus, kidney, bladder, and intestines, and is a component of RAAS, which serves to maintain vascular tone and blood volume. Inhibition or activation of other components of RAAS has been shown to directly increase or decrease the expression and/or activity of ACE2. Furthermore, RAAS-targeting therapeutics, such as ACE inhibitors and ARBs, have also been shown to regulate the expression and/or activity of ACE2, albeit in animal models. Although these changes in ACE2 have been demonstrated only in animal models, there is no evidence that administration of RAAS-targeting therapeutics to humans for the treatment of hypertension, diabetes, and other cardiovascular diseases (e.g., myocardial infarction and heart failure) causes changes in ACE2 expression. Nor is there clinical evidence that RAAS-targeting therapeutics augment COVID-19 infection, morbidity, or mortality. However, clinical evidence does suggest that ACE2 expression may protect against respiratory distress caused by a variety of noxious agents. This review attempts to provide a balanced overview of the potential role of RAAS in regulating ACE2, and the role of ACE2 during COVID-19 infection. Evidence is provided to show that the expression of ACE2 may mediate both positive and negative outcomes, depending on the timing of ACE2 expression.

Preprint BRIEF REPORT | doi:10.20944/preprints202003.0295.v1

DNA Methylation Analysis of the COVID-19 Host Cell Receptor, Angiotensin I Converting Enzyme 2 Gene (ACE2) in the Respiratory System Reveal Age and Gender Differences

Michael J. Corley, Lishomwa C. Ndhlovu

Subject: Biology And Life Sciences, Virology Keywords: Wuhan 2019-nCoV; ACE2; DNA methylation; epigenetics; profiling; lung tissue; age; gender; COVID-19; coronavirus

Online: 19 March 2020 (02:51:45 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202003.0275.v1

Chloroquine as a Potential Treatment and Prevention Measure for the 2019 Novel Coronavirus: A Review

John Kearney

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Antimalarial; Chemoprophylaxis; Chloroquine; Coronavirus; COVID-19; Global Health; Hydroxychloroquine; Public Health; SARS-CoV-2; Virus

Online: 17 March 2020 (09:17:53 CET)

Show abstract| Download PDF| Share

Preprint COMMUNICATION | doi:10.20944/preprints202002.0418.v2

Virtual Screening Based Prediction of Potential Drugs for COVID-19

Sekhar Talluri

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: virtual screening; molecular docking; drug repurposing; drug repositioning; anti-viral drugs; Coronavirus; COVID-19; 2019-nCoV; SARS-CoV-2

Online: 9 March 2020 (02:29:04 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202208.0463.v1

Long-Term Antibody Response against SARS-CoV-2 in Health Care Workers: Effectiveness of Homologous and Heterologous Regimens and their Relation to Systemic Vaccine-Associated Symptoms

Helene Kierkegaard, Birgit Thorup Røge, Amanda Nissen, Jonna Skov Madsen

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19 vaccines; vaccine effectiveness; BNT162b2 vaccine; mRNA-1273 vaccine; ChAdOx1 vaccine; 19 Elecsys Anti-SARS-CoV-2 S assay; reactogenicity; vaccine-associated symptoms

Online: 26 August 2022 (14:14:39 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202410.0217.v1

The Road to Recovery: A Two-Year Longitudinal Analysis of Mental Health Among University Students During and After the Covid-19 Pandemic

Rosie Allen, Kevin Hochard, Chathurika Kannangara, Jerome Carson

Subject: Social Sciences, Psychology Keywords: Mental health; Psychological wellbeing; University students; Anxiety; Psychological distress; Flourishing; Higher Education; Longitudinal research; Covid-19

Online: 3 October 2024 (10:55:27 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202410.0067.v1

Assessing the Impact of Different Face Masks on Results of Forensic Automatic Speaker Recognition Systems

Attila Fejes, André Saraiva, Jelena Devenson

Subject: Physical Sciences, Acoustics Keywords: Forensic Automatic Speaker Recognition (FASR); Forensic Multilingual Voices Database (FMVD); face masks; COVID-19; system performance

Online: 1 October 2024 (13:02:16 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202409.2464.v1

Exploring the Contrasts and Similarities of Dengue and SARS-CoV-2 Infections during the COVID-19 Era

Alexis Hipólito García, Juan Bautista De Sanctis

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: dengue infection; SARS-CoV-2 infection; COVID-19; platelets; antibodies; cytokine storm; antibody-dependent enhancement (ADE)

Online: 30 September 2024 (18:24:17 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202409.2298.v1

The “Politi-COVID^(USA)” Epidemic in the “Pre-Election” America, 2020 and 2024

Jan Charles Biro

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: COVID-19; pandemic; political; mortality; age; aging; co-morbidity; underlying cause of death; UCOD; USA; States

Online: 29 September 2024 (07:54:25 CEST)

Show abstract| Download PDF| Share

Background: The COVID infection became the source of serious disagreements between scientists, doctors, politicians and private citizens, directly after it’s detection in the population in January 2020. The pandemic had some very unusual properties as well as the people’s reaction to it. It was feared, that the virus might be used, intentionally or accidentally, to interfere with the usual, democratic way of the upcoming election. Objective: Re-search the original COVID statistic and metadata to obtain better understanding of the pandemic including the biological (viral) as well as the social (human) aspects of it. Provide a professional, independent, non-biased view of the pandemic, that is not polluted by political and media suggestions. Methods: Publicly available data – covering the first 5 months of the COVID pandemic, 2020 Jan-May - were collected and analyzed with the usual, common statistical methods, like student’s t-test and regression analyses.The political attitude of the states were characterized by a ratio (D/R) of the number of left, democrat (D) and right, republican (R) oriented citizens in the respective states, as determined by opinion research. Results: De novo statistical analyzes of publicly available data (covering the initial five months of the pandemic) suggests that the negative medical consequences of COVID pandemic were significantly more expressed in “democrat-dominated” (D) states than in “republican-dominated”, (R) states. The proportion of COVID test positive persons was higher in D-states (6.831 +/- 1605, n=14 and 1,165 +/- 323, n=13 respectively, p<0.001). The difference in mortality was even more striking, 8-times more person/million population died in COVID related conditions in solid D states than in solid R states (438 +/- 128, and 59 +/- 13; p<0.001, respectively). The COVID associated mortality increased two fold from right to left on the political scale of the states (2.7% +/- 0.3 vs. 5.3% +/- 0.5, p<0.001). The correlation between COVID deaths (mortality) and the age/pre-existing medical condition(s) of the diseased is very strong (R2= 0.98) and the overwhelming majority of COVID “victims” are persons who were close to death even independently of the epidemic. Conclusions: Alarming signals regarding the dangerousness of COVID infection seems to have originated in a few states with predominantly left oriented citizens (high D/R ratio). The COVID mortality statistic seems to be seen and analyzed with little or no respect for the context of mortality caused by other well-known diseases or even by the natural, age related deaths. We conclude that it is absolutely necessary to pay serious attention to the correct analyses and interpretation of the epidemic data to avoid being misled or manipulated by false circumstances.

Preprint ARTICLE | doi:10.20944/preprints202409.0491.v1

Dynamics of SEPAIVRD model for COVID-19 in Bangladesh

Amit Kumar Saha, Goutam Saha, Pabel Shahrear

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: Presymptomatic; Asymptomatic; Vaccinated; COVID-19; Local stability; Global stability; Equilibrium points; Bounded and non-negative solutions

Online: 6 September 2024 (09:36:58 CEST)

Show abstract| Download PDF| Share

Background: Since 2020, when the Covid-19 outbreak began, researchers worldwide have been investigating its biological processes, transmission patterns, and the mathematical expression of this infectious disease. Multiple mathematical models have been presented thus far, with the simplest being the SIR model. The question now is whether the SIR model can provide a comprehensive representation of Covid-19 or if a more intricate model is necessary. With this in mind, the SEPAIVRD model has been developed. Objective: This study focuses on understanding the third wave of Covid-19 that began in mid-May 2021 in Bangladesh. To achieve this, we introduced three essential compartments in our model: Presymptomatic (P), Asymptomatic (A), and Vaccinated (V) classes. The Asymptomatic class will help us determine how close the population is to achieving herd immunity. The Presymptomatic class will provide insight into whether we can effectively control Covid-19 by identifying infected individuals over an extended period. Lastly, the Vaccinated class will allow us to explore how the Presymptomatic class affects those who have received the vaccine. The results of this study aim to address these questions. Findings: According to the study findings, an increase in vaccination rates could result in a decrease in the number of people getting infected every day, lessening the strain on healthcare resources and lowering the risk of transmission to others. Moreover, the research highlights the significance of using highly effective vaccines to combat COVID-19 cases and fatalities, particularly in areas with low vaccination rates. Additionally, implementing social distancing measures can be an effective approach to contain the spread of the virus by reducing the effective contact rate. Conclusion: The model presented in this study provides a comprehensive overview of Covid-19 transmission in Bangladesh. Furthermore, this model can be applied to other countries in South Asia and is therefore a valuable mathematical model for understanding Covid-19.

Preprint REVIEW | doi:10.20944/preprints202408.0481.v1

Challenges of Treating a Helicobacter pylori Infections following the COVID-19 Pandemic in Croatia: A Review

Ivana Jukic, Jonatan Vukovic

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: H. pylori; COVID-19; antibiotic resistance; antimicrobial stewardship; antibiotic consumation; eradication therapy

Online: 7 August 2024 (07:02:52 CEST)

Show abstract| Download PDF| Share

Background: Helicobacter pylori (H. pylori) is a prevalent bacterial pathogen implicated in various gastroduodenal diseases, including chronic gastritis, peptic ulcer disease, and gastric cancer. The COVID-19 pandemic has significantly influenced antibiotic prescription practices, potentially exacerbating antibiotic resistance in H. pylori. Objective: This study aims to investigate antibiotic prescription during COVID-19 pandemic in Croatia and its possible impact on H. pylori antibiotic resistance, with a focus on Croatia. Methods: A comprehensive literature search was conducted to identify relevant studies from March 2020 to June 2024. The search strategy included terms related to COVID-19, antibiotic prescription, and Croatia. Studies were selected based on predefined eligibility criteria, focusing on observational research addressing antibiotic use during the pandemic. Results: The COVID-19 pandemic leads to significant fluctuations in community antibiotic consumption within the European Union/European Economic Area. In Croatia, antibiotic use in 2022 surpassed 2019 levels, driven by increased consumption of macrolides and other antibiotics. This surge, influenced by early pandemic treatment claims and penicillin shortages, contributed to rising antibiotic resistance in H. pylori. Resistance rates to clarithromycin and levofloxacin were notably high, driven by mutations in the 23S rRNA, gyrA, and gyrB genes. Discussion: The increased antibiotic use during the COVID-19 pandemic has highly likely complicated H. pylori eradication efforts, highlighting the necessity of judicious antibiotic use and robust antimicrobial stewardship. The pandemic underscored the need for new therapeutic strategies, optimized eradication regimens, and advanced diagnostic methods to manage bacterial infections effectively. Conclusions: The COVID-19 pandemic has significantly impacted antibiotic use and resistance patterns, posing new challenges for H. pylori eradication. Addressing these challenges requires a multifaceted approach, including the development of new drugs and advanced diagnostics, coupled with sustained efforts in antimicrobial stewardship to combat emerging resistance threats.

Preprint ARTICLE | doi:10.20944/preprints202407.0727.v1

Machine Learning Data Processing for COVID‐19 Diagnostics

Boris Gorbunov, Alexander Chapovsky

Subject: Biology And Life Sciences, Other Keywords: ML algorithm; pattern recognition; Gas chromatography-ion mobility; COVID-19 volatile biomarkers

Online: 10 July 2024 (08:00:11 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202407.0229.v1

Enhancing Mental Health in Stressed College Students during COVID-19: The Impact of Positive Psychology-Based Virtual Music Therapy

Jinwoo Han, Hyejin Lee, Teri Kim, Sangyeol Lee

Subject: Public Health And Healthcare, Other Keywords: virtual music therapy; positive psychotherapy; mental health; stress reduction; anxiety; depression; self-efficacy; resilience; COVID-19

Online: 3 July 2024 (04:24:50 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202406.0438.v1

Policy and Crisis Management During the COVID-19 Pandemic in Poland

Mieczysław Adamowicz

Subject: Business, Economics And Management, Business And Management Keywords: COVID-19 pandemic; economic crisis; health policy; anti-crisis policy; consequences of the pandemic in Poland

Online: 7 June 2024 (11:28:20 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.0024.v1

The Critical Issues for Patients and Caregivers in Neuro-Oncology During Covid-19 Pandemic: What We Have Learnt by an Observational Study.

Elena Anghileri, Irene Tramacere, Sara Morlino, Catia Leuzzi, Lorena Pereja Gutierrez, Saba Motta, Antonio Silvani, Francesca Romana Berrini

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Anxiety; Caregivers; Caregiver Burden; Communication; COVID-19; (Brain) Neoplasms; Pandemics; Perception; Psycho-Oncology; Quality of Life

Online: 1 April 2024 (10:08:02 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202403.0356.v1

Redefining the Narrative: How Work from Home Job Demands Elevate Workplace Anxiety but Enhance Psychological Capital

Frank Magwegwe, Snenhlanhla Sithole

Subject: Social Sciences, Psychology Keywords: COVID-19; digital technology characteristics; job demands; job insecurity; psychological capital; work from home; workplace anxiety

Online: 20 March 2024 (09:48:30 CET)

Show abstract| Download PDF| Share

Search Results

2747 articles found