REVIEW
|
doi:10.20944/preprints202404.1722.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Perrault syndrome type 3 (PRLTS3); iron toxicity; pyridoxal-5'-phosphate; VWA8; GFM1; PNPT1; RNA-G4; ISC; ALAS; OAT
Online: 26 April 2024 (11:39:46 CEST)
ARTICLE
|
doi:10.20944/preprints202404.0719.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Lynch syndrome; mismatch repair gene PMS2; alternative splicing; RNA splicing; splicing muta-tions; exon skipping; splicing regulatory elements
Online: 10 April 2024 (09:13:16 CEST)
ARTICLE
|
doi:10.20944/preprints202401.0225.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
clear cell renal cell carcinoma; non-coding RNA; cancer therapy; orthotopic mouse renal model; patient-derived primary cultures
Online: 3 January 2024 (10:03:39 CET)
ARTICLE
|
doi:10.20944/preprints202312.1981.v1
Subject:
Medicine And Pharmacology,
Pathology And Pathobiology
Keywords:
SINE-VNTR-Alu; transposable elements; whole genome sequencing; RNA-seq; quantitative trait loci; Amyotrophic Lateral Sclerosis; HLA; MAPT
Online: 26 December 2023 (11:27:43 CET)
ARTICLE
|
doi:10.20944/preprints202305.0024.v1
Subject:
Biology And Life Sciences,
Neuroscience And Neurology
Keywords:
Key Words Putrescine; spermidine; spermine; tri-lysine; tetra-lysine; penta-lysine; DNA-conformation; RNA-conformation; indirect buffer system
Online: 1 May 2023 (10:50:20 CEST)
REVIEW
|
doi:10.20944/preprints202303.0448.v1
Subject:
Biology And Life Sciences,
Life Sciences
Keywords:
LLPS; liquid-liquid phase separation; non-coding RNA; intrinsically disordered proteins; membrane-less organelles; stress-response; biomolecular condensates
Online: 27 March 2023 (05:43:50 CEST)
REVIEW
|
doi:10.20944/preprints202302.0429.v1
Subject:
Medicine And Pharmacology,
Dermatology
Keywords:
RNA therapeutics; skin; mRNA therapeutics; siRNA therapeutics; antisense oligonucleotide ther-apeutics; ASO; melanoma; hypertrophic scars; wound healing; dermatology
Online: 27 February 2023 (01:53:06 CET)
ARTICLE
|
doi:10.20944/preprints202206.0219.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
Equid alphaherpesvirus 1; EHV-1; transcriptome; replication origin; long-read sequencing; nanopore sequencing; direct RNA sequencing; Illumina sequencing
Online: 15 June 2022 (09:30:44 CEST)
TECHNICAL NOTE
|
doi:10.20944/preprints202111.0256.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
planarian; maceration; high-content fluorescence microscopy; formaldehyde fixation; RNA FISH; immunocytochemistry; BrdU; phospho-histone H3; tyramide signal amplification
Online: 15 November 2021 (11:44:53 CET)
ARTICLE
|
doi:10.20944/preprints202104.0344.v1
Subject:
Computer Science And Mathematics,
Algebra And Number Theory
Keywords:
Lysine; Rice; Amino Acids; Saline Stress; Abiotic Stress; Gene Regulatory Network; Bayesian Network; Parameter Estimation; Inference; RNA Seq
Online: 13 April 2021 (10:52:26 CEST)
ARTICLE
|
doi:10.20944/preprints201907.0140.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
PlGF; PGF; blood-retinal barrier; RNA Seq; HREC; gene ontology; fastQC; Trimmomatic; KEGG; pentose phosphate pathway; TGF-β
Online: 10 July 2019 (07:48:20 CEST)
ARTICLE
|
doi:10.20944/preprints202408.1078.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
RNA structure prediction; K-type pseudoknots; M-type pseudoknots; syntactic pattern recognition; context-free grammar; secondary structure; computational biology
Online: 14 August 2024 (14:39:34 CEST)
ARTICLE
|
doi:10.20944/preprints202401.0415.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
Ixodid ticks; Flaviviridae; Jingmenvirus group; Kindia tick virus; orthoflavivirus; flavi-like virus; segmented virus; phylogenetics; RNA structure; untranslated region
Online: 5 January 2024 (09:30:15 CET)
COMMUNICATION
|
doi:10.20944/preprints202309.1589.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
acute myeloid leukemia; acute lymphoblastic leukemia; single-cell RNA sequencing; Down syndrome, trisomy 21; personalized medicine; multi-omics approach
Online: 25 September 2023 (04:20:18 CEST)
ARTICLE
|
doi:10.20944/preprints202304.0773.v1
Subject:
Biology And Life Sciences,
Animal Science, Veterinary Science And Zoology
Keywords:
Key words: transcriptome profiles; long non-coding RNAs; single-nucleotide polymorphisms; alternative splicing; sheep; preimplantation; Single-cell RNA sequencing
Online: 23 April 2023 (04:57:02 CEST)
ARTICLE
|
doi:10.20944/preprints202205.0336.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Long non-coding RNA; Prostate androgen-regulated transcript 1; miR-204-3p; insulin-like growth factor binding protein 2
Online: 24 May 2022 (11:57:26 CEST)
REVIEW
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
coronavirus; COVID-19; Hepatitis C Virus (HCV); Human Immunodeficiency Virus (HIV); Influenza viruses ribonucleic acid (RNA); SARS-CoV-2
Online: 19 February 2021 (14:34:38 CET)
REVIEW
|
doi:10.20944/preprints201806.0036.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
varicella-zoster virus; latency; reactivation; sensory ganglia; VZV latency-associated transcript; open reading frame 63; RNA-sequencing; epigenetics; immunity
Online: 4 June 2018 (11:49:09 CEST)
REVIEW
|
doi:10.20944/preprints202404.1097.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
Lipid metabolism; RNA virus replication; Rotavirus; hepatitis C virus; flaviviruses; picornaviruses; no-roviruses; HIV-1; SARS-CoV-2; influenza viruses
Online: 17 April 2024 (15:03:18 CEST)
ARTICLE
|
doi:10.20944/preprints202404.1124.v1
Subject:
Chemistry And Materials Science,
Nanotechnology
Keywords:
exosomes; proton sponge; RNA; CRISPR/Cas; small molecules; cancer; gene editing; vaccines; biological barriers; nanoparticle-tracking assay; dynamic light scattering
Online: 17 April 2024 (08:40:29 CEST)
ARTICLE
|
doi:10.20944/preprints202303.0389.v1
Subject:
Computer Science And Mathematics,
Artificial Intelligence And Machine Learning
Keywords:
antisense oligonucleotides; exon skipping; machine learning; ensemble learning; personalized medicine; n-of-1 therapy, splice switching; genetic disease; splicing; RNA
Online: 22 March 2023 (03:24:48 CET)
ARTICLE
|
doi:10.20944/preprints202303.0167.v1
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
antisense oligonucleotides; exon skipping; machine learning; ensemble learning; personalized medicine; n-of-1 therapy; splice switching; genetic disease; splicing; RNA
Online: 9 March 2023 (04:43:55 CET)
ARTICLE
|
doi:10.20944/preprints201811.0620.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
gene-first; protein-first; replicator-first; metabolism-first; origin of life; [GADV]-protein world hypothesis; GADV hypothesis; RNA world hypothesis
Online: 30 November 2018 (07:33:15 CET)
ARTICLE
|
doi:10.20944/preprints202407.1837.v1
Subject:
Biology And Life Sciences,
Neuroscience And Neurology
Keywords:
epigenetics; burn injury; pain; spinal cord; dynorphinergic neuron; histone H3; histone H3 post-translational modification (PTM); p-S10H3; RNA-seq; WES
Online: 24 July 2024 (06:58:30 CEST)
ARTICLE
|
doi:10.20944/preprints202407.1672.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
immune imbalance; Immune Imbalance Transcriptomics; IIT; B-cell lymphoma; Systemic Lupus Erythematosus (SLE); RNA-seq; algorithm; drug discovery; cancer; autoimmune disease
Online: 22 July 2024 (09:33:39 CEST)
REVIEW
|
doi:10.20944/preprints202312.2337.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
COVID-19; SARS-CoV-2; transcriptomics; RNA-seq; scRNA-seq; inflammation; pneumonia; neuronal COVID; acute respiratory disease syndrome; multisystem inflammatory syndrome
Online: 30 December 2023 (16:01:23 CET)
REVIEW
|
doi:10.20944/preprints202110.0005.v1
Subject:
Biology And Life Sciences,
Endocrinology And Metabolism
Keywords:
Brown adipose tissue; beige adipose tissue; obesity; cold exposure; uncoupling protein-1, beta-adrenergic receptor; energy expenditure; adipose browning; micro-RNA
Online: 1 October 2021 (11:30:39 CEST)
REVIEW
|
doi:10.20944/preprints202011.0013.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
APOBEC; RNA virus replication; DNA virus replication; AID; HIV-1 Vif; genome hypermutation; MMTV Rem; G-to-A mutations; viral variants
Online: 2 November 2020 (10:06:10 CET)
ARTICLE
|
doi:10.20944/preprints202008.0632.v1
Subject:
Computer Science And Mathematics,
Mathematical And Computational Biology
Keywords:
Blockchain; P2P Networks; Nucleobase DNA/RNA sequence; Gene Expression; Cell Population; Epigenetics; Methylation; Consensus; Hash Algorithm; Triple Codons; Protein Synthesis; Cryptocurrency
Online: 28 August 2020 (10:33:42 CEST)
ARTICLE
|
doi:10.20944/preprints202403.1437.v1
Subject:
Biology And Life Sciences,
Ecology, Evolution, Behavior And Systematics
Keywords:
Mycobacterium leprae; Mycobacterium tuberculosis; translation efficiency; translation initiation; translation elongation; translation termination; RNA secondary structure; rrn operons; tRNA
Online: 25 March 2024 (08:53:51 CET)
ARTICLE
|
doi:10.20944/preprints202012.0252.v1
Subject:
Social Sciences,
Psychology
Keywords:
Fear extinction; Fear Conditioning; Medial Prefrontal Cortex; RNA sequencing; Differential Gene Expression; Electrophysiological Recordings; Excitatory Post-Synaptic Currents; Spinogenesis; Fear-related Disorders
Online: 10 December 2020 (11:38:50 CET)
REVIEW
|
doi:10.20944/preprints202407.2158.v2
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
immune system; natural immunity; adaptive immunity; interferon system; plasmacytoid dendritic cells; lymphocytes; viruses; bacteria; fungi; DNA; RNA; evolution; molecular self camouflaging; innovation; vaccines
Online: 2 August 2024 (11:36:10 CEST)
REVIEW
|
doi:10.20944/preprints202405.2001.v1
Subject:
Biology And Life Sciences,
Plant Sciences
Keywords:
mosaic-virus; novel viruses; pathogen-derived resistance; RNAi; artificial microRNA; plant gene editing; NB-LRR protein; nanoparticle RNA delivery; plant disease; crop protection
Online: 30 May 2024 (10:51:19 CEST)
ARTICLE
|
doi:10.20944/preprints202403.0787.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
EZH2; Enhancer of zeste homolog 2; TKS4; signal transduction; long non-coding RNA; migration; invasion; EMT; epithelial-mesenchymal transition; Frank-Ter Haar syndrome
Online: 13 March 2024 (14:37:30 CET)
REVIEW
|
doi:10.20944/preprints202403.0435.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
3D DNA Structures; Genome Editing (CRISPR-Cas); Genomic Regulation; Genetic Disorders; Computational Genomics; Non-coding RNA Interactions; Ethical, Legal, and Social Implications (ELSI)
Online: 7 March 2024 (12:01:10 CET)
ARTICLE
|
doi:10.20944/preprints202306.2136.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
Virus diagnosis; RNA; recombinant virus; alphacoronavirus; deltacoronavirus; porcine epidemic diarrhea virus (PEDV); transmissible gastroenteritis virus (TGEV); swine enteric coronavirus (SeCoV); porcine deltacoronavirus (PDCoV)
Online: 29 June 2023 (13:22:32 CEST)
REVIEW
|
doi:10.20944/preprints202007.0712.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
Group-B Enterovirus; RNA domain-I; viral ribonucleoprotein complexes; Enterovirus replication; 5’ terminally deleted viral forms; antiviral innate immune response; type I Interferon
Online: 30 July 2020 (10:00:13 CEST)
ARTICLE
|
doi:10.20944/preprints202407.0833.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
acylation; arginine; breast cancer; cell-penetrating peptide; histidine; MDA-MB-231; oleic acid; RNA interference; siRNA; SK-OV-3; STAT-3; tryptophan; western blotting
Online: 10 July 2024 (10:51:00 CEST)
ARTICLE
|
doi:10.20944/preprints202402.0355.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Mn porphyrin clinical candidate, MnTnBuOE-2-PyP5+ (BMX-001, MnBuOE); Single-cell RNA sequencing; Tumor heterogeneity; Tumor microenvironment; Radiotherapy; Tumor radiosensitization
Online: 6 February 2024 (09:43:28 CET)
REVIEW
|
doi:10.20944/preprints202106.0377.v2
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
aa = amino acids; ACE-2 = receptor angiotensin-converting enzyme 2; cDNA = complementary DNA; mRNA = messenger RNA; orf = open reading frame; RBD = receptor binding protein; S-protein = Spike protein; SARS-CoV-2 = severe respiratory syndrome coronavirus 2; Vaccines.
Online: 22 June 2021 (11:53:34 CEST)
ARTICLE
|
doi:10.20944/preprints201909.0146.v1
Subject:
Biology And Life Sciences,
Biophysics
Keywords:
entropy; entropy production; non-equilibrium thermodynamics; information encoding; nucleic acids; DNA; RNA; origin of life; origin of codons; amino acids; stereochemical era; photon potential
Online: 14 September 2019 (19:44:54 CEST)
REVIEW
|
doi:10.20944/preprints201712.0170.v1
Subject:
Biology And Life Sciences,
Life Sciences
Keywords:
RNA world; [GADV]-protein world; GADV hypothesis; origin of life; protein 0th-order structure; origin of protein; origin of genetic code; origin of gene
Online: 25 December 2017 (08:08:37 CET)
ARTICLE
|
doi:10.20944/preprints201912.0358.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
fibromyalgia; Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS); HERV (Human Endogenous Retrovirus); transposable elements; epigenetics; DNA methylation; tsRNAs (transfer RNA small fragments); interferon; non-Hodgkin's lymphoma
Online: 27 December 2019 (03:30:53 CET)
ARTICLE
|
doi:10.20944/preprints201809.0082.v1
Subject:
Medicine And Pharmacology,
Cardiac And Cardiovascular Systems
Keywords:
atherosclerosis; coronary aortic disease; gene set enrichment analysis; heart disease; Apoe mouse; transcriptomics; RNA-seq analysis; pathway enrichment analysis; mouse; precision medicine; New Zealand White rabbit
Online: 5 September 2018 (04:49:40 CEST)
ARTICLE
|
doi:10.20944/preprints202311.0853.v1
Subject:
Biology And Life Sciences,
Life Sciences
Keywords:
liquid-liquid phase separation; membrane-less organelles; stress granules; P-bodies; intrinsically disordered proteins; intrinsically disordered regions; aging; senescence; protein aggregation; nucleic acids; RNA-binding protein; DNA-binding protein
Online: 14 November 2023 (16:38:59 CET)
REVIEW
|
doi:10.20944/preprints202310.0414.v1
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
primate evolution genetics; noncoding genome; immunogenetics; neurogenetics; neurobiology; cell biology; molecular biology; neurological diseases; cardiovascular diseases; brain-immune system interactions; nucleic acid therapeutics; RNA interference; AAV vectors; blood-brain-barrier
Online: 8 October 2023 (07:20:59 CEST)
ARTICLE
|
doi:10.20944/preprints202008.0470.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Amyotrophic Lateral Sclerosis (ALS); Fronto-Temporal-Lobar-Dementia; Tauopathies; synaptic plasticity; long-term potentiation; spatial learning; inositol signaling; neurexin; K-homology RNA-binding domain; Fragile-X-associated Tremor-Ataxia syndrome
Online: 21 August 2020 (04:39:19 CEST)
REVIEW
|
doi:10.20944/preprints202310.1077.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
accretion model; convergent evolution model; divergent evolution model; folding of first proteins; genetic code evolution; origin of life; pseudosymmetry; ribozyme/primitive catalyst RNA ligation; type I and type II tRNA evolution
Online: 17 October 2023 (11:01:52 CEST)
ARTICLE
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
protein/rna world; plasma membrane; cytoplasm; virus world; pre-retro virus; emergence of dna; transcription and replication; first cells; hyperthermophiles; luca; bacteria and archaea; anoxygenic bacteria; oxygenic bacteria; global distribution of cyanobacteria
Online: 15 October 2019 (11:18:58 CEST)
REVIEW
|
doi:10.20944/preprints201903.0108.v1
Subject:
Biology And Life Sciences,
Cell And Developmental Biology
Keywords:
Nucleolar sequestration, nucleolus, physiological amyloids, ribosomal intergenic spacer, rIGSRNA, liquid-liquid phase separation, liquid-to-solid phase transition, complex coacervation, biomolecular condensates, beta-amyloid, MDM2, VHL, Cdc14, low complexity RNA, acidosis, heat shock
Online: 8 March 2019 (15:12:29 CET)
ARTICLE
Subject:
Environmental And Earth Sciences,
Paleontology
Keywords:
protein/RNA world: plasma membrane; cytoplasm; gene regulation; virus world; pre-retro virus; emergence of DNA; transcription and replication; first cells; hyperthermophiles; LUCA; Bacteria and Archaea; anoxygenic bacteria; oxygenic bacteria; global distribution of cyanobacteria
Online: 12 February 2020 (03:25:07 CET)
ARTICLE
|
doi:10.20944/preprints201812.0203.v1
Subject:
Chemistry And Materials Science,
Organic Chemistry
Keywords:
peptide/RNA world; prebiotic information system; translation and the genetic code; coevolution of translation machine and the genetic code; MVC architecture pattern and biological information; numerical codons; AnyLogic software for computer simulation of translation machine
Online: 17 December 2018 (16:03:16 CET)
ARTICLE
|
doi:10.20944/preprints201810.0127.v1
Subject:
Environmental And Earth Sciences,
Other
Keywords:
hierarchical origin of life; RNA/protein world; biological information system; translation and the genetic code; coevolution of translation machine and the genetic code; MVC architecture pattern and biological information; AnyLogic software for computer simulation of translation machine
Online: 8 October 2018 (05:33:22 CEST)
REVIEW
|
doi:10.20944/preprints202402.1353.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
Infectious disease agents in aquaculture; Fish Vaccine, Fish immunology; Bacterial, viral, and parasitic diseases in aquaculture; Recombinant live attenuated, subunit, DNA, and RNA vaccines for fish; Sustainability of aquaculture; The innate and adaptive immune system of fish; Fish immunological mechanisms
Online: 24 February 2024 (08:58:46 CET)
REVIEW
|
doi:10.20944/preprints202406.1184.v3
Subject:
Biology And Life Sciences,
Virology
Keywords:
SARS-CoV-2; polymorphic virus; variant; species; environment; positive-sense; single-stranded RNA; zoonosis; bats; pangolins; minks; viral isolation; outbreak; epidemic; pandemic; RT-PCR; innate immunity; first-line; second-line; adaptive immunity; third-line; democracy; autocracy; ideology; natural selection; artificial selection; gain-of-function; cloud seeding; scientific integrity
Online: 20 June 2024 (08:57:35 CEST)