Gastrointestinal stromal tumors are the mostly seen mesenchymal tumors of the gastrointestinal system and mostly seen at the stomach. We report a case of giant gastrointestinal stromal tumor of the stomach in a 71-year-old woman. The physical examination and radiological findings revealed that a giant mass occupied most of the abdominal cavity. The patient underwent an en-block resection of this giant mass with partial resection of the distal stomach and transverse colon and, reconstruction with gastro-jejunostomy and end-to end colo-colic anatomoses. The histopathologic diagnosis was revealed as gastrointestinal stromal tumor of the stomach. We suggest that complete surgical resection is the only effective radical treatment approach for giant gastrointestinal stromal tumors of the stomach.

With the continuing development of sequencing technology, genomics has been applied in a variety of biological research areas. In particular, the application of genomics to marine species, which boast a high diversity, promises great scientific and industrial potential. Significant progress has been made in marine genomics especially over the past few years. Consequently, BGI, leveraging its prominent contributions in genomics research, established BGI-Qingdao, an institute specifically aimed at exploring marine genomics. In order to accelerate marine genomics research and related applications, BGI-Qingdao initiated the International Conference on Genomics of the Ocean (ICG-Ocean) to develop international collaborations and establish a focused and coherent global research plan. Last year, the first ICG-Ocean conference was held in Qingdao, China, during which 47 scientists in marine genomics from all over the world reported on their research progress to an audience of about 300 attendees. This year, we would like to build on that success, drafting a report on marine genomics to draw global attention to marine genomics. We summarized the recent progress, proposed future directions, and we would like to enable additional profound insights on marine genomics. Similar to the annual report on plant and fungal research by Kew Gardens, and the White Paper of ethical issues on experimental animals, we hope our first report on marine genomics can provide some useful insights for researchers, funding agencies as well as industry, and that future versions will expand upon the foundation established here in both breadth and depth of knowledge.This report summarizes the recent progress in marine genomics in six parts including: marine microorganisms, marine fungi, marine algae and plants, marine invertebrates, marine vertebrates and genomics-based applications.

In previous studies we used Laurent Schwartz’ theory of distributions to rigorously introduce discretizations and periodizations on tempered distributions. These results are now used in this study to derive a validity statement for four interlinking formulas. They are variants of Poisson’s Summation Formula and connect four commonly defined Fourier transforms to one another, the integral Fourier transform, the Discrete-Time Fourier Transform (DTFT), the Discrete Fourier Transform (DFT) and the Integral Fourier transform for periodic functions—used to analyze Fourier series. We prove that under certain conditions, these four Fourier transforms become particular cases of the Fourier transform in the tempered distributions sense. We first derive four interlinking formulas from four definitions of the Fourier transform pure symbolically. Then, using our previous results, we specify three conditions for the validity of these formulas in the tempered distributions sense.

Vertebrate color vision is evolutionarily ancient. Jawless fish evolved four main spectral types of cone photoreceptor, almost certainly complemented by retinal circuits to process chromatic opponent signals. Subsequent evolution of photoreceptors and visual pigments are now documented for many vertebrate lineages and species, giving insight into evolutionary variation and ecological adaptation of color vision. We look at organization of the photoreceptor mosaic and the functions different types of cone in teleost fish, primates, and birds and reptiles. By comparison less is known about the underlying neural processing. Here we outline the diversity of vertebrate color vision and summarize our understanding of how spectral information picked up by animal photoreceptor arrays is adapted to natural signals. We then turn to the question of how spectral information is processed in the retina. Here, the quite well known and comparatively ‘simple’ system of mammals such as mice and primates reveals some evolutionarily conserved features such as the mammalian Blue^ON system which compares short and long wavelength receptors signals. We then survey our current understanding of the more complex circuits of fish, amphibians, birds and reptiles. Together, these clades make up more than 90% of vertebrate species, yet we know disturbingly little about their neural circuits for colour vision beyond the photoreceptors. Here, long-standing work on goldfish, freshwater turtles and other species is being complemented by new insights gained from the experimentally amendable retina of zebrafish. From this body of work, one thing is clear: The retinal basis of colour vision in non-mammalian vertebrates is substantially richer compared to mammals: Diverse and complex spectral tunings are established at the level of the cone output via horizontal cell feedforward circuits. From here, zebrafish use cone-selective wiring in bipolar cells to set-up color opponent synaptic layers in the inner retina, which in turn lead a large diversity of color-opponent channels for transmission to the brain. However, while we are starting to build an understanding of the richness of spectral properties in some of these species’ retinal neurons, little is known about inner retinal connectivity and cell-type identify. To gain an understanding of their actual circuits, and thus to build a more generalised understanding of the vertebrate retinal basis of color vision, it will be paramount to expand ongoing efforts in deciphering the retinal circuits of non-mammalian models.

Carburizing of stainless steels at low temperatures (below 500°C) develops a high content carbon layer, known for its high hardness. X-ray Diffraction investigation indicates that carburization treatment does not impact the structure of substrate; however, introduced carbon causes expansion in the carburized layer through the increase in d-spacing. Characterization of carbon concentration and hardness profiles indicate that carbon content gradually decreases while moving further into the substrate; and the origin of the increased hardness of the expanded layer arises from the super-saturated carbon content, following the solid solution strengthening theory. An area that is not well understood is in regard to the carburized layer’s relation to the substrate and the significance in their differences. Using two grades of stainless steel, AISI 316L and PH 17-4, it was observed that the carburized layer is not a separate layer, but a higher carbon content version of the substrate,

Pencil-beam Doppler scatterometers are a promising remote sensing tool for measuring ocean vector winds and currents from space. While several point designs exist in the literature, these designs have been constrained by the hardware they inherited, and the design is sub-optimal. Here, I present guidelines to optimize the design of these instruments starting from the basic sensitivity equations. Unlike conventional scatterometers or pencil-beam imagers, appropriate sampling of the Doppler spectrum and optimizing the radial velocity error lead naturally to a design that incorporates a pulse-to-pulse separation and pulse length that vary with scan angle. Including this variation can improve radial velocity performance significantly and the optimal selection of system timing and bandwidth is derived. Following this, optimization of the performance based on frequency, incidence angle, antenna length, and spatial sampling strategy are considered. It is shown that antenna length influences the performance most strongly, while the errors depend only on the square root of the transmit transmit power. Finally, a set of example designs and associated performance are presented.

The language we use to describe the past can have a strong influence on the audience’s interpretation of our story. In our experiment, we explore, using 3 different conditions, how the framing and language of an accident report can affect the audience’s proposed solutions to manage the problems found. We find that the approach used to create an accident report can have a powerful influence on the audience’s decision making. Whether we are describing an accident in a similar manner to a crime, using a systems approach or we are accepting of multiple stories which are not linear or coherent, the methods we use to capture and communicate the story have a profound impact on the actions decided upon by the reader.

Vibrational spectroscopies (FTIR, Raman) are exceptionally valuable tools for the identification and crystal-chemical study of fibrous minerals, and asbestos amphiboles in particular. Raman spectroscopy has been widely applied in toxicological studies and thus a large corpus of reference data on regulated species is found in the literature. However, FTIR spectroscopy has been mostly used in crystal-chemical studies and very few data are found on asbestos amphiboles. This paper is intended to fill this gap; we report new FTIR data collected on a suite of well-characterized samples of the five regulated amphibole species: anthophyllite, amosite and crocidolite, provided by the Union for International Cancer Control (UICC) Organization, and tremolite and actinolite, from two well-known occurrences. The data from these reference samples have been augmented by results from additional specimens to clarify some aspects of their spectroscopic features. We show that the FTIR spectra in both the OH-stretching region and in the lattice modes region can be effective for rapid identification of the asbestos type.

Paper presents the energy policy of the Republic of Serbia with special attention to the energy situation on the government controlled territory. South Serbian autonomous province of Kosovo and Metohija is under UN jurisdiction since the 1999 according to UNSC Resolution 1244. Renewable energy sources are rarely used in Serbia with exception of energy from hydropower plants, but in this sector priorities in geothermal and energy coming from biomass recently increased. In natural gas sector, Serbia has the deal with Russia for construction of South Stream gas-line through Serbia and for construction of the first underground storage in depleted gas reservoir in Banatski Dvor. In 2008, Serbia also sold 51% of the government founded petroleum industry – NIS which has exclusive monopoly for exploitation of crude oil. Serbian government has complete monopoly in electric power sector. Electric power infrastructure became technologically obsolete, and operative efficiency is at very low level. Serbia has not yet decided whether Serbian Electric Power Industry – EPS will be privatized. District heating sector mostly natural gas fuelled is highly inefficient and it is in jurisdiction of local municipalities but also has social component dictated by central government.

In this paper, the modification of two synthetic steps to obtain EMICORON, with respect to the usual protocol, is reported. EMICORON is a benzo[ghi]perylen-diimmide which was synthesized the first time in our laboratory in 2012 and showed to have in-vivo antitumor activities interfering with tumor growth and development by a multi-target mechanism of action. The provided modifications regarded the reaction times and the reaction conditions as well as the work-up procedures and allowed to increase the global yield of the process from 28% to about 40%. Thus, this new procedure may be more suitable in order to get larger amounts of EMICORON for further preclinical studies.

Following an event damaging the DNA, p53 levels increases inducing cell cycle arrest or apoptosis. JMY protein is a transcription co-factor involved in p53 regulation. After a DNA damage, also JMY levels increase and, as this protein accumulates in the nucleus, it forms a complex with P300 and Strap1 which increases the ability of p53 to induce transcription of proteins triggering apoptosis but not cell cycle. Therefore, Increase levels of JMY “direct” p53 activity toward triggering apoptosis. JMY expression is also linked to increased motility as it downregulates the expression of adhesion molecules of the Cadherin family and induces actin nucleation, making the cell less adhesive and more mobile. According to the scenario this gene can therefore have both a suppressive or a tumour promoting activity.

All cancer registries constantly show striking differences in cancer incidence by age and among tissues. For example, lung cancer is diagnosed hundreds of times more often at age 70 than at age 20, and this cancer in nonsmokers occurs thousands of times more frequently than heart cancer in smokers. An analysis of these differences using basic concepts in cell biology indicates that cancer is the end-result of the accumulation of cell divisions in stem cells. In other words, the main determinant of carcinogenesis is the number of cell divisions that the DNA of a stem cell has accumulated in any type of cell from the zygote. Cell division, process by which a cell copies and separates its cellular components to finally split into two cells, is necessary to produce the large number of cells required for living. However, cell division can lead to a variety of cancer-promoting errors, such as mutations occurring during DNA replication, chromosome aberrations arising during mitosis, errors in the distribution of cell-fate determinants between the daughter cells, and failures to restore physical interactions with other tissue components. Some of these errors are spontaneous, others are promoted by endogenous DNA damage occurring during quiescence, and others are influenced by pathological and environmental factors. The cell divisions required for carcinogenesis are primarily caused by multiple local and systemic physiological signals rather than by errors in the DNA of the cells. As carcinogenesis progresses, the accumulation of DNA errors promotes cell division and eventually triggers cell division under permissive extracellular environments. The accumulation of cell divisions in stem cells drives not only the accumulation of the DNA alterations required for carcinogenesis, but also the formation and growth of the abnormal cell populations that characterize the disease. This model of carcinogenesis provides a new framework for understanding the disease and has important implications for cancer prevention and therapy.

For evaluating probabilities of arbitrary random events with respect to a given multivariate probability distribution, specific techniques are of great interest. An important two-dimensional high risk limit law is the Gauss-exponential distribution whose probabilities can be dealt with based upon the Gauss-Laplace law. The latter will be considered here as an element of the newly introduced family of (p,q)-spherical distributions. Based upon a suitably defined non-Euclidean arc-length measure on (p,q)-circles we prove geometric and stochastic representations of these distributions and correspondingly distributed random vectors, respectively. These representations allow dealing with the new probability measures similarly like with elliptically contoured distributions and more general homogeneous star-shaped ones. This is demonstrated at hand of a generalization of the Box-Muller simulation method. En passant, we prove an extension of the sector and circle number functions.

A new copper(I) complex, [Cu2(L)2dppm](PF6)2 (1) [L = 3-(2-Pyridyl)-5,6-diphenyl-1,2,4-triazine and dppm: Bis(diphenylphosphino)methane] was prepared and characterized by IR, 1H-NMR, 31P-NMR spectroscopy, elemental and thermogravimetric analysis, and single-crystal X-ray diffraction technique. Complex 1 is a dinuclear compound, showing that L and dppm act as tridentate and bidentate chelating ligands, respectively. The two Cu(I) atoms exhibit a distorted tetrahedral coordination sphere embedded in N3P environments. The supramolecular interactions in the solid-state structure are characterized by C−H···N, C−H···F, C-H···π and π···π intermolecular interactions that were analyzed by inspection of the Hirshfeld surface and fingerprint plots. Additionally, the complex was studied experimentally in solution by UV–Vis spectroscopy and cyclic voltammetry; also, theoretical studies with Time-Dependent Density Functional Theory (TD-DFT) were performed. Moreover, the optical and electrochemical properties have been studied, focusing on the band gap. Compound 1 has been used as a co-sensitizer in a dye-sensitized solar cell, showing good activity.

The genus Chaetogaster belongs to the subfamily Naidinae (Naididae), includes mostly species of small size and is diverse and abundant in surface coarse sediments in streams. The aim of the present study is to initiate an inventory of lineages of Chaetogaster in Switzerland. We used 135 specimens collected at six sites in four streams of four cantons. We sequenced the cytochrome c oxidase (COI) gene from all specimens and ITS2 and rDNA 28S from all or several specimens of each lineage delimited using COI data and preserved a voucher of almost all sequenced specimens. We could delimit one lineage (=species) for Chaetogaster diaphanus (Gruithuisen, 1828), three within Chaetogaster diastrophus (Gruithuisen, 1828), one for Chaetogaster langi Brestcher, 1896, one for Chaetogaster setosus Svetlov, 1925 and three unidentified Chaetogaster spp. Two lineages of Chaetogaster spp. could correspond to a new morphological group, but this should be confirmed on more specimens. We described the three C. diastrophus lineages and two Chaetogaster spp. as new species for science. The prospects of the present work are to complete the data of the molecular diversity of this genus in Switzerland and to describe on a molecular/morphological basis the new Chaetogaster species that we will probably find.

Extracellular vesicles (EVs) are natural carriers of biomolecules that play a crucial role in cell-to-cell communication and tissue homeostasis under normal and pathological conditions, including inflammatory diseases and cancer. Since the discovery of the pro-regenerative and immune-modulating properties of EVs, EV-based therapeutics have entered clinical trials for conditions such as myocardial infarction and autoimmune diseases, among others. Due to their unique advantages—such as superior bioavailability, substantial packaging capacity, and the ability to traverse biological barriers—EVs are regarded as a promising platform for targeted drug delivery. However, achieving sufficient accumulation of therapeutic agents at the target site necessitates a larger quantity of EVs per dose compared to using EVs as standalone drugs. This challenge can be addressed by administering larger doses of EVs, increasing the drug dosage per administration, or enhancing the selective accumulation of EVs at target cells. In this review, we will discuss methods to improve the isolation and purification of EVs, approaches to enhance cargo packaging—including proteins, RNAs, and small-molecule drugs—and technologies for displaying targeting ligands on the surface of EVs to facilitate improved targeting. Ultimately, this guide can be applied to the development of novel classes of EV-based therapeutics and to overcoming existing technological challenges.

For many tick-borne organisms, dogs may be utilized as sentinel hosts to estimate the risk of human infection. The detection of antibodies in these animals indicates the circulation of pathogens in each location for a set period of time. The standard protocol for the surveillance of tick-borne diseases established by the Brazilian National Reference Laboratory for Rickettsiosis at the Ezequiel Dias Foundation (FUNED) includes testing the seropositivity of dogs for Rickettsia spp. and Ehrlichia canis. Dog serum samples were collected during FUNED’s surveillance protocol in a preserved area in Brazil. Despite Anaplasma phagocytophilum being endemic in Brazil, this agent is not included in FUNED’s standard protocol. To determine if A. phagocytophilum should be included in the standard testing protocol, a collaboration with Fuller Laboratories was established and the seropositivity for A. phagocytophilum was tested. The estimated prevalence for singular infections: 25% Rickettsia spp.; 52.3% E. canis; and 70.5% A. phagocytophilum. The estimated prevalence for co-infections: 17% Rickettsia spp. and E. canis; 18.2% Rickettsia spp. and A. phagocytophilum; 39.8% E. canis and A. phagocytophilum; and 13.6% Rickettsia spp., E. canis, and A. phagocytophilum. These results confirmed a significant presence of A. phagocytophilum and establishes a potential threat upon the public health.

: This study was aimed at assessing adaptation and bonding of discontinuous (short) glass fiber-reinforced composite to intraradicular dentin EverX Flow (GC Corporation, Tokyo, Japan), when used as intracanal composite filling and anchorage instead of traditional fiber posts. (2) Methods: Seventy intact extracted human teeth were endodontically treated and randomly divided into 6 groups (n=10), depending on the materials used in the post space. In Group 1, a 2-bottle universal adhesive G2 Bond Universal + EverX Flow were tested. In group 2, a single-component universal adhesive G-Premio Bond + EverX Flow were used. In groups 3 and 4 the same materials are tested, but after cleaning of the canal walls with 17% EDTA and final irrigation with 5.25% NaOCl Ultrasound Activated. In the last three Groups (5-7) traditional prefabricated GC Fiber Posts 1.6 mm silanized with G-Multi Primer for 1 minute are cemented with a dual-cured composite resin cement (GradiaCore), after ultrasonic irrigation in the groups 6 and 7. In each group, 1 mm-thick slices from each sample (n=10) were cut for light microscope and SEM inspection for study materials adaption to the dentin and for measuring push-out strength of post / cemement material to the dentin / prefabricated post. These results were statistically analyzed: as the data distribution was not normal, the Kruskal-Wallis Analysis of Variance by Ranks had to be applied. The level of significance was set at p<0.05. Results: Push-out forces varied between 6.66-8.37 MPa. No statistically significant differences were recorded among the groups. Microscopic examination showed that ultrasonic irri-gation increased adaptation of the materials to the dentin surface. There was a trend of higher bond strength among the tested groups when EverX Flow was used. Also, the type of failure was more often cohesive when ultrasonic irrigation and two-step adhesive system were used. Conclusions: Within the limitations of this in vitro study, it may be concluded that when EverX Flow was used for intracanal anchorage in the post-endodontic recon-struction, similar push-out retentive forces and strength to those of traditional fiber posts cemented with particulate filler resin composite cements were achieved. Although further studies are necessary, EverX Flow represents an effective alternative to traditional fiber post adhesion in particular when used in combination with the two-step adhesive system and ultrasonic activation.

The present study aims to unravel the mechanisms of salicylic acid and rehydration and the physiological benefits in pepper plants grown under water deficit. 3x4 factorial scheme adopted, with three water regimes (irrigated, dry and rehydration) and four SA concentrations, namely: 0 (control), 0.5, 1 and 1.5 mM. Evaluated leaf moisture percentage, leaf water potential, chlorophylls (a and b), carotenoids, stomatal conductance, chlorophyll a fluorescence and H2O2 concentration at different times throughout the day and water conditions (irrigated, dry and rehydration) and SA applications (without the addition of the regulator (0) and with SA addition at concentrations equal to 0.5, 1 and 1.5 mM). Exogenous SA application favored stomatal conductance responses(gs) and modified fluorescence parameters (Fm, Fo, Fm', Fo', Fv/Fm, qP, ETR and NPQ) of sweet pepper plants subjected to drought followed by rehydration. SA concentration of 0.5 mM allowed a more expressive recovery of gs indices, effective quantum yield of photosystem II, with emphasis on excess energy (E) and maximum quantum yield (FV/FM) over time in plants subjected to drought and rehydration. We discovered that the use of SA, especially in association with rehydration, by modulating the variables gs and chlorophyll a fluorescence, prevents damage to membranes and consequently mitigates water deficit in pepper plants.

Malnutrition problems are related to diets that lack one or more essential elements, which it is extremely important to food enrichment to improve the content of compounds effective for health. The objective of this study is to evaluate the effect of the addition of Ca2+, K+ and Mg2+ on the induction of nutraceutical quality in grafted tomatoes grown in the NFT (Nutrient Film Technique) system. In the experiment, two factors were evaluated: plants with and without grafting and the foliar application of 10 ml L−1 Ca2+, 4 ml L−1 K+ and 10 ml L−1 Mg2+ cations separately for each case, in addition to the control. The treatments were evaluated using a completely randomized design, with 5 repetitions per treatment. The interactive effects between grafting and foliar application of Ca2+ induced a greater content lycopene, β-carotene and total flavonoids in fruits of tomato. The interactive effects between the graft and the Mg2+ foliar applications obtained the best results in the phenol content. As regards, capacity DPPH and ABTS, the graft decreased concentration, increasing the content of these through foliar applications of calcium. Regarding the enzymatic variables, graft factor increased activity catalase, glutathione peroxidase and phenylalanine ammonium lyase, obtained the best results graft interaction and foliar application of calcium and magnesium. The results obtained demonstrate the influence of the use of grafts and foliar applications of cal-cium and magnesium as tools that could improve the nutraceutical quality content of tomato crop

This investigation aimed to knowledge of the presence of Brucella spp .in the samples from Babylon province and the relationship with environmental factors. The seasonal collection of animal soil samples for various villages in the middle, south, and north of Babylon province, Hilla City, Iraq, with physicochemical parameters (air and soil temperature, pH, EC, TDS, salinity, TOC), as well as heavy metals (Fe, Cu, Cd, and Pb). The results showed the presence of Brucella species in some of soil samples and its percentage varies according to the four seasons, where the highest percentage of Brucella spp. was in summer season and the lowest in winter season and these percentages were related to seasonal environmental indicators. After sending the positive bacterial samples isolated from the soil for sequencing analysis, it was found that the bacterial samples isolated from the soil have new strains recorded in Genbank as following: five strains for Brucella intermedia and one strain for Brucella rhizosphaerae, Also, phylogenetic analysis was for the drawing of phylogenetic tree and the determination of phylogenetic relationship for Knowledge the degree of convergence between species and their source. Through our research, we concluded that proportion of Brucella spp. presence in summer was high and also environmental factors which included (Air and Soil temperature, pH, EC, TDS and Salinity) were high, except TOC was lower in summer season whereas heavy metals for Cu, Fe, Cd were lower in summer except Pb was high. This indicated that differences of seasons affect to Brucella ratio in soil. The findings of sequencing for the bacterial samples from soil demonstrated that B. intermedia was found in both the spring and fall seasons while B.rhizosphaerae found in the spring season , These types of Brucella had genetic variations. Also concluded that during phylogenetic analysis of the 16S rRNA sequences indicated that B.intermedia was nearest to Pakistan and other strain of B.intermedia was nearest to Russia while B.rhizosphaerae was nearest to Ukraine and Pakistan.

Grapevine trunk diseases (GTDs) attack the vine's wood, devastating vineyards worldwide. Chile is the world's fourth largest wine exporter, and Cabernet Sauvignon leads the red wine varieties. Botryosphaeria dieback is an important GTDs and Diplodia seriata is one of the main pathogenic species. Biocontrol studies of these pathogens are commonly carried out at different incubation times but at a single temperature. This study aimed to evaluate the biocontrol effect of native Chilean bacteria against D. seriata isolates at different temperatures. We analyzed the biocontrol effects of Pseudomonas sp. GcR15a, Pseudomonas sp. AMCR2b and Rhodococcus sp. PU4, with three D. seriata isolates (PUCV 2120, PUCV 2142 and PUCV 2183) at 8, 22 and 35°C. Agar plug diffusion and double plate methods were used to evaluate the effect of diffusible and volatile organic compounds (DOC and VOC), and an in vivo test was performed with Cabernet Sauvignon cuttings. Pseudomonas strains showed the most significant inhibition in the DOC assay, and a demelanizing activity was observed. Rhodococcus sp. PU4 showed VOC biocontrol potential at high temperatures (35°C). In vivo, a biocontrol effect was observed against two D. seriata isolates, while the PUCV 2142 isolate proved to be more resistant to being controlled. The biocontrol ability at low temperatures is promising for effective control in the field, where infections occur primarily in winter.

Keywords: Lightning; Land Cover and Land Use; Topographic Effects, Itacaiúnas River Hydrographic Basin

Morphological study of lakes defines the sensitivity of their watershed. Moreover, it plays important role in safeguarding the lake’s ecosystem services through proper planning and utilization of the lakes’ resources. In the last few decades, the morphology of lakes in Ethiopian and Kenyan Rift (EKR) valley are experiencing contradicting morphological changes. Being in the same system, some are shrinking and others are expanding beyond their natural boundaries. The objective of this review is to shed light on the trends in spatio-temporal water level fluctuation and their contributing factors for lakes to the academia and decision makers. Peer reviewed article journals, conference proceedings, thesis, and book chapters collected from online sources and supplied by authors on request formed a database of 346 documents where 226 are critically assessed. The review indicated that lakes in Ethiopian rift are shrinking and expanding, while Kenyan lakes are expanding. The en-dorheic lakes suffered the most fluctuations due to anthropogenic factors at the expense of loss of forest and woodlands in their watershed. While the lakes’ water quality related to the morphological changes are given less attention, the predicted 12 m drop of Lake Turkana due to projects in the Omo catchment did not materialize.

Eating disorders are a global burden and present personal, family, and societal costs. Most evidence in the literature is based on the relationship between a poor family environment and eating disorders, and the evidence of gender interaction in eating disorders is inconsistent. This study aimed to investigate the relationship between family functioning and disordered eating patterns, the mediating role of negative automatic thoughts, and the moderating role of gender. A sample of 440 (70.9% females, aged 18–21) participated in this study. They completed the Eating Attitudes Test (EAT-26), the Automatic Thoughts Questionnaire (ATQ negative), and the Brief Family Relationship Scale (BFRS). PROCESS MACRO was used to study these relationships. The main findings revealed that family functioning was negatively associated with eating disorders, and that this relationship was negatively mediated by automatic thoughts. Moreover, gender moderated those relationships, and more intensely in females. The results of this study postulate that the prevention of eating disorders should be directed at training individuals to challenge negative thoughts and encourage healthy individuals to be gender mindful.

Prosocial behavior is vital for positive social development among adolescents, contributing to improved peer relationships, emotional well-being, and social competence. Gratitude, a positive emotion arising from recognizing and appreciating benefits received from others, has been identified as a potential contributor to adolescent prosocial behavior. This study aimed to investigate the mediating roles of social support and basic psychological needs in the relationship between gratitude and prosocial behavior among adolescents. A total of 390 middle school students participated in a longitudinal study, completing questionnaires assessing gratitude, social support, basic psychological needs, and prosocial behavior at two time points with a six-month interval. The results indicated that gratitude positively correlated with social support, basic psychological needs, and prosocial behavior. Structural equation modeling revealed that social support and basic psychological needs partially mediated the relationship between gratitude and adolescent prosocial behavior. Moreover, a chain-like mediation effect was observed, wherein social support influenced basic psychological needs, which in turn predicted prosocial behavior. These findings emphasize the importance of gratitude in fostering prosocial behavior among adolescents and highlight the mediating roles of social support and basic psychological needs in this relationship.

Background: Studies exploring the possible protective effect of coffee and tea consumption on dementia showed inconsistent results so far. We aimed to investigate whether consumption of tea and different types of coffee at midlife are associated with dementia later in life and, whether sex or ApoE4 influence such association. Methods: We included 7381 participants from the Norwegian HUNT Study. Self-reported questionnaires assessed daily consumption of coffee and tea at baseline. After 22 years, individuals 70 years or older were screened on cognitive impairment. Results: General coffee consumption and tea consumption was not associated with dementia risk. Compared to daily consumption of 0-1 cups of coffee, daily consumption of ≥8 cups of boiled coffee was associated with increased dementia risk in women (OR:1.83, 95% CI: 1.10-3.04, p-value for trend=0.03) and daily consumption of 4-5 cups of other types of coffee was associated with a decrease in dementia risk in only men (OR 0.48, 95% CI: 0.32-0.72, p-value for trend =0.05). Furthermore, the association between boiled coffee and increased dementia risk was only found in ApoE4 non-carriers. Differences by sex or ApoE4 carrier status were not supported by strong statistical evidence for interaction. Conclusion: Type of coffee may play a role in the direction of the association between coffee-drinking habits and dementia later in life.

Hormones act as master ripening regulators. In non-climacteric fruit ABA plays a key role in ripening. Recently we confirmed in Fragaria chiloensis fruit that in response to ABA treatment the fruit induces ripening associated changes such as softening and color development. In consequence with these phenotypic changes, transcriptional variations associated with cell wall disassembly and anthocyanins biosynthesis were reported. As ABA stimulates ripening of F. chiloensis fruit, the molecular network involved in ABA metabolism was analyzed. Therefore, the expression level of genes involved in ABA biosynthesis and ABA perception were quantified during development of the fruit. Four NCED/CCDs and 6 PYR/PYLs family members were identified in F. chiloensis. Bioinformatics analyses confirmed the existence of key domains related to functional properties. Through RT-qPCR analyses the level of transcripts were quantified. FcNCED1 codifies a protein that displays crucial functional domains and the level of transcripts increased as the fruit develops and ripens, in parallel with the increment in ABA. In addition, FcPYL4 codifies for a functional ABA receptor and its expression follows an incremental pattern during ripening. The study concludes that FcNCED1 is involved in ABA biosynthesis, meanwhile FcPYL4 participates in ABA perception during ripening of F. chiloensis fruit.

For consciousness to exist, an entity must have prerequisite characteristics and attributes to give rise to it. We explore these “building blocks” of consciousness in detail in this paper, which range from perceptive to computational to higher-order characteristics of an entity’s cognitive architecture. We show how each cognitive attribute is strictly necessary for the emergence of consciousness, and how the building blocks are collectively sufficient for any entity to be classified as being conscious. The list of building blocks is not limited to human or organic consciousness and may be used to classify artificial and organisational conscious entities. We further explore a list of attributes that seem intuitively necessary for consciousness, but on further investigation, are neither required nor sufficient. The building blocks do not represent a theory of consciousness but rather a meta-theory on the emergence and classification of consciousness.

This review is devoted to present the history of CARDIOSIM© software simulator platform, which was developed in Italy to simulate the human cardiovascular and respiratory system. The first version of CARDIOSIM© was developed at the Institute of Biomedical Technologies of the National Research Council in Rome. The first platform version published in 1991 ran on PC with disk operating system (MS-DOS) and was developed using the Turbo Basic language. The last version runs on PC with Microsoft Windows 10 operating system; it is implemented in Visual Basic and C++ languages. The platform has a modular structure consisting of seven different general sections, which can be assembled to reproduce different pathophysiological conditions. The software simulator can reproduce the most important circulatory phenomena in terms of pressure and volume relationships. It represents the whole circulation using a lumped-parameter model and enables the simulation of different cardiovascular conditions according to Starling’s law of the heart and a modified time-varying elastance model. Different mechanical ventilatory and circulatory devices have been implemented in the platform including thoracic artificial lung, ECMO, IABP, pulsatile and continuous right and left ventricular assist devices, biventricular pacemaker and biventricular assist devices. CARDIOSIM© is used in clinical and educational environment.

Levels of synthetic musk fragrances (SMFs) and various personal care products (PCPs) were measured in the Han River and its tributaries in Seoul, Korea. The most abundant SMF in all river and PCP samples was 4,6,6,7,8,8-hexamethyl-1,3,4,7-tetrahydrocyclopenta[g]isochromene (HHCB), followed by 1-(3,5,5,6,8,8-hexamethyl-6,7-dihydronaphthalen-2-yl)ethanone (AHTN), musk ketone (MK), and 1,1,2,3,3-pentamethyl-2,5,6,7-tetrahydroinden-4-one (DPMI). There was a significant correlation between the SMF concentration in the PCPs and the Han River samples. Moving from upstream to downstream in the Han River, the median SMF concentration was 6.756, 2.945, 0.304, and 0.141 μg/L in the sewage treatment plant (STP) influent, effluent, tributaries, and mainstream, respectively, implying that effective SMF removal was achieved during the sewage treatment process, followed by dilution in the receiving water. Four STPs using advanced biological treatment processes had removal efficiencies of 55.8%, 50.6%, 43.3% for HHCB, AHTN, and MK, respectively. The highest SMF concentrations in the tributaries were observed at locations close to the STPs. Our study confirmed that the main source of SMFs in the receiving water were sewage effluent containing untreated SMFs, which are largely originated from household PCPs, especially hair care products (e.g., shampoo) and perfumes.

This paper presents a comparative analysis of the ZVZCS soft switching technique with the ZVS and the ZCS counterpart. The generalization of the voltage-current crossover or the energy loss factor obtained from simulation of the prototype converter shows that the ZVZCS significantly reduces the loss and helps to improve the efficiency of the converter as compared to the ZVS or the ZCS. On the other hand, it is also found that the soft switching range of operation of the ZVS and the ZCS are largely affected by the maximum switch voltage and switch current respectively. In contrary, these factors have a negligible effect on the ZVZCS operation which results in an extended range of soft switching operation. Additionally, a detailed LTPICE simulation is performed for selected ZVS, ZCS and ZVSCS topologies from the recent literature and the switching losses in the main switches of the converters are measured. It is observed that the energy losses in the ZVZCS mode are reduced on average by approximately 26 % at turn on and 20 % at the turn off as compared to the ZVS and the ZCS. Besides, the low standard deviation in this mode confirms a stable low loss profile which renders extended soft switching range. An experimental test is also conducted by building the prototype converter to verify the simulation results. It is found that the switching losses are minimum while the converter is operated in the ZVZCS mode. Besides, the efficiency drop remains consistently low as compared to the ZVS and the ZCS in the whole operating range. Resultantly, the simulation and the experimental results are both found to be consistent.

Continuum robots play the role of end-effector in various surgical robots and endoscopic devices. The robots may be categorized as rigid or soft continuum robots (SCRs). While the SCRs have proven advantages such as safety and compliance, more research and development are required to enhance their capability for specific medical scenarios. This research aims at designing a soft robot considering concepts of geometric and kinematic similarities. The chosen application is a semi-invasive medical application known as Transesophageal Echocardiography (TEE), but the methodology can be implemented in other similar applications. Since established rigid carrier construction make use of principles we find as well embodied in vertebral spines, the paragon for soft robot solution can be the phylogenetic precursor of the spine, the Chorda dorsalis. The feasibility of fabrication of a soft endoscopic device derived from that paragon within a robotics laboratory was shown empirically by producing a three-segment pneumatic SCR. The kinematic model was proposed based on the method of transformation matrices, and an algorithm based on a self-organizing map (SOM) was proposed and applied to realize kinematic similarity. The simulation results indicate that the algorithm acting as an open-loop controller forces the soft robot tip to follow the desired path which in this case is the path of the rigid probe. It is concluded that the solution provides a soft robot that can surrogate and succeed the traditional rigid counterpart owing to size, workspace, and kinematics.

Variant H3.3, along with H2A.Z, is notably enriched at promoter regions and is commonly associated with transcriptional activation. However, the specific molecular mechanisms through which H3.3 influences chromatin dynamics at transcription start sites, and its role in gene regulation, remain elusive. Using a combination of biochemistry and cryo-electron microscopy (cryo-EM), we show that the inclusion of H3.3 alone does not induce discernible changes in nucleosome DNA dynamics. Conversely, the presence of both H3.3 and H2A.Z enhances DNA flexibility similarly to H2A.Z alone. Interestingly, our findings suggest that the presence of H3.3 in the H2A.Z nucleosome provides slightly increased protection to DNA near the superhelical location (SHL) -5.5/5.5. These results imply that while H2A.Z at active promoters promotes the formation of more accessible nucleosomes with increased DNA accessibility to facilitate transcription, the simultaneous presence of H3.3 offers an additional mechanism to fine-tune nucleosome accessibility and the chromatin environment.

In this article, we present two topics related to mathematical economics. We offer an intriguing proposal for securing cost and production functions in the face of uncertainty and risk. We discuss the relationship between individual and social preferences. This is important because traditional revealed preference theory does not account for such factors.

The conceptualisation of happiness varies across different cultures. In Chinese culture, happiness is not only inclusive of oneself, but also hinges on the people is related to and society. Chinese social development have influenced psychological traditionality and modernity and individual's happiness. In Experienment1, 450 participants were recruited and surveyed to examine the levels of happiness amongst Chinese undergraduates with diverse cultural values. The results showed that individuals with both traditional and modern psychological orientations had high levels of happiness. Those with higher psychological traditionality showed more satisfaction with family relationships and social happiness, while those with higher psychological modernity demonstrated a higher level of relational happiness. In Experienment2, 280 participants were recruited, and a "happiness token distribution" and "happiness importance survey" were employed to draw a 'happiness circle' for Chinese undergraduates. The results revealed that those with a higher degree of psychological traditionality assigned a greater proportion of their happiness to ascribed relationships. In contrast, those with a higher degree of psychological modernity allocated a larger share of their happiness to interactive relationships and social relationships. Individuals with lower values of both traditionality and modernity perceived themselves as the most important component in their happiness circle.

Microorganisms present in fermented foods and beverages play a vital role in enhancing both nutritive and non-nutritive components. During the fermentation, microorganisms can either naturally occur in the food through spontaneous fermentation or be intentionally added as starter cultures with a variety of species and strains. In this review, the focus is placed on micronutrients, such as vitamins and minerals, and three major macromolecules – prebiotics, bioactive peptides, and functional fatty acids. During fermentation, non-digestible carbohydrates like fructooligosaccharides and galactooligosaccharides are synthesized, imparting prebiotic properties that support gut health. Enzymatic hydrolysis of proteins by microorganisms yields bioactive peptides with diverse health benefits. Furthermore, fermentation facilitates the formation of fatty acids, including short-chain fatty acids and conjugated linoleic acid, potentially exerting physiological effects. By harnessing the power of microbial fermentation, nutrient-rich and bioactive compounds can be enhanced, offering a promising approach to address global malnutrition concerns.

Ovarian tissue cryopreservation (OTC) or testicular tissue cryopreservation (TTC) are effective and often the only options for fertility preservation in female or male patients due to oncological, medical, or social aspects. While TTC and resumption of spermatogenesis, either in vivo or in vitro, has still be considered an experimental approach in humans, OTC and autotransplantation has been applied increasingly to preserve fertility with more than 200 live births worldwide. However, the cryopreservation of reproductive cells followed by the resumption of gametogenesis, either in vivo or in vitro, may interfere with sensitive and highly regulated cellular processes. In particular, the epigenetic profile, which includes not just reversible modifications of the DNA itself but also post-translational histone modifications, small non-coding RNAs, gene expression and availability, and storage of related proteins or transcripts, have to be considered in this context. Due to complex reprogramming and maintenance mechanisms of the epigenome in germ cells, growing embryos, and offspring, OTC and TTC are carried out at very critical moments early in the life cycle. Given this background, the safety of OTC and TTC taking into account the epigenetic profile has to be clarified. Cryopreservation of mature germ cells (including Metaphase II oocytes and mature spermatozoa collected via ejaculation or more invasively after testicular biopsy) or embryos has been used successfully for many years in Medically Assisted Reproduction (MAR). However, tissue freezing followed by in vitro or in vivo gametogenesis has become more attractive in the past, while few human studies have analysed the epigenetic effects, with most data deriving from animal studies. In this review, we highlight the potential influence of the cryopreservation of immature germ cells and subsequent in vivo or in vitro growth and differentiation on the epigenetic profile in humans and animals.

TeamIndus’ Lunar Logistics vision includes multiple lunar missions over the coming years to meet requirements of science, commercial and efforts towards building readiness for crewed missions to Mars in the global exploration roadmap. TeamIndus is the only Indian team that participated in the Google Lunar X Prize. The challenge called for privately funded spaceflight teams to be the first to land a robotic spacecraft on the Moon, travel 500 meters, and transmit back high-definition video and images. The first mission is expected to have a net landed payload capacity of 50 kg. The prime objective is to demonstrate autonomous lunar landing, and operations for a Surface Exploration Rover - to collect data in the vicinity of the landing site. The rover is designed to execute the commands given by the operations manager autonomously. The rover software architecture relevant to the navigation and control is described in detail. The functional modes are defined to functionally distinguish the rover drive. Among the various operations performed by the rover are execution of simple drive steps through navigation and control algorithms. The kinematic model of the rover is studied in the hardware locomotion tests performed. The Kalman filter formulation to estimate the sensor bias and to get attitude estimate is discussed. The structural model and the frame definitions are described in a relevant section. A simple heading control algorithm is designed to control the heading direction of the rover according to the operations requirement. The path planning process and visual odometry processes are described. Finally the SIMULINK$^{\textregistered}$ model is tested on the prototype rover and the test experience results are discussed in the last section.

After brings about a brief review of the theoretical explanations and researches on the reasons for being a victim, this article is organized into two sections. The first presents a comparative analysis of the data for 1999 and 2016 in terms of perceptions, profiles and most significant sociodemographic and socioeconomic variables. The second one shows an explanatory analysis based on a multivariate logistical regression model using as an independent variable lifestyle of the population and socioeconomic variables, and as dependent variables individual’s susceptibility to becoming a victim of certain crimes. The results points towards an explanatory model of victimization in which sociodemographic variables play an increasingly less important role while variables related to lifestyle and subjective perceptions make a significant contribution to greater understanding of the nature of being the victim of a crime.

Friction and wear take place on two solid surfaces in sliding contact as a result of the mechanical, thermal and chemical interactions with the participation of environmental species. Electron microscopy and the associated spectroscopic analyses are powerful in probing these mechanisms in spatial resolutions from micro to atomic scale. This article provides a review of the author’s work in the wear and friction mechanisms of PVD hard coatings in which various SEM- and TEM-based microscopic and spectroscopic techniques were employed. Understanding on the failure mechanisms and the origin of self-adaptive friction has been improved to nano-scale. Other related issues are also discussed, such as sample preparation techniques for cross-sectional electron microscopy, energy dispersive X-ray spectroscopy and electron energy loss spectroscopy.

This article is a followup to an earlier review which outlined some of the interesting features of the soliton/wave-action potential (AP) model, and noted the need to test its key aspects; including the need to test if its presumed lipid phase transition is actually happening during AP firings in excitable cells. The intent here is to point out the sort of tests, and evidence from them, that might be needed if the soliton/wave-AP model is to be accepted broadly by biologists. Here, after an overview of the modern electrophysiological-AP model and of the soliton/wave-AP model, there are three areas considered. First, possible compositional influences on membrane properties relative to the soliton/wave-AP model are presented. Including questions with regard to the soliton/wave-AP model’s assumption that changes in surface potentials influence the transmembrane potential. Second, some recent work from the good folks who advocate for the soliton/wave-AP model concerning the occurrence of lipid phase transitions in neurons or in extracts from nervous tissues are examined. Here it is noted that there is a need to consider whether these lipid phase transitions happen within normal physiological conditions or not. Third, and finally, the advocates for the soliton/wave-AP model have adopted a thermodynamic/theory-based philosophical approach in their studies. It is argued that this philosophical approach is a radical departure from the philosophical approach used under the scientific method. The features of this new approach, and implications its use, are examined.

In this paper, the effect of multi-pass friction stir processing on the mechanical properties of AZ91 alloy has been studied. For the numerical investigation, this process has been simulated with the three-dimensional numerical modeling based on the ABAQUS/Explicit. This simulation involves the Johnson-Cook models for defining the material behavior during this intense plastic deformation and investigating the fracture criterion. The tool plunging and stirring phases in the two-pass process has been simulated. To prevent too much distortion of elements during modeling, the Arbitrary Lagrangian-Eulerian technique for automatically re-meshing of distorted elements has been used. The model was calibrated using the experimental results from the previous works. This model can predict the transient temperature distribution and residual stress field during FSP on AZ91. The results show that the maximum temperature in the advancing-side region is more than that in the retreating-side region. In addition, numerical results show that at the end position of the process, the tool during the lift-up leaves the keyhole region in the compressive stress state. The experimental results investigated the effect of multi-pass FSP on the microstructure, microhardness, tensile and creep properties of AZ91 magnesium alloy. The FSP is performed by applying 50% overlapping. The tensile, and creep tests are conducted at several temperatures from 25 to 210 °C. The optical microscopy and scanning electron micrograph (SEM) were used to study the microstructure of the samples after performing multi-pass friction stir processing. The experimental results indicate that on average, the tensile strength, microhardness, and creep strength of the processed samples increased by about 29, 23, and 38 %, respectively compared to the unprocessed ones.

In order to study the crystallinity of different density polyethylenes, the experimental study on the transformation of the conductance mechanism under high electric field was carried out. The X-ray Diffraction(XRD), Different Scanning Calorimeter(DSC), Direct Current(DC) breakdown of Low-density polyethylene(LDPE), Linear low density polyethylene(LLDPE), Medium density polyethylene(MDPE) and High-density polyethylene(HDPE) and the electric field of 5-200kV/mm were tested. Conductivity characteristics experiments, in addition, using the mathematical formula of a variety of conductance mechanisms, the electric field-current density curves of the four kinds of polyethylene were fitted to analyze the conductance transition of the above four kinds of polyethylene in non-ohmic regions under different high field strengths. mechanism. The experimental results show that as the density of polyethylene increases, the crystallinity increases continuously, and the continuous increase of crystallinity causes the electric conduction flow under the same field strength to decrease significantly. The field strength corresponding to the two turning points in the conductance characteristic curve increases simultaneously. Large, the breakdown field strength increases; through analysis, it is found that in the high field, as the electric field increases, the conductance mechanism develops from the ohmic conductance of the low field strength region to the bulk effect of the high field strength region (Poole-Frenkel). Then the electrode effect to the high field strength (Schottky), and the threshold field strength of this conductance mechanism transition increases with the increase of crystallinity.

The effect of microstructure and chemistry of passive films on the kinetics of passive layer growth and passivity breakdown of some Ti-based alloys, namely Ti-6Al-4V, Ti-6Al-7Nb and TC21 alloys was studied. The rate of pitting corrosion was evaluated using cyclic polarization measurements. Chronoamperometry was applied to assess the passive layer growth kinetics and breakdown. Microstructure influence on the uniform corrosion rate of these alloys was also investigated employing Tafel extrapolation and dynamic electrochemical impedance spectroscopy. Corrosion studies were performed in 0.9% NaCl solution at 37 oC, and the obtained results were compared with ultrapure Ti (99.99%). The different phases of the microstructure were characterized by X-ray diffraction and scanning electron microscopy. Chemical composition and chemistry of the corroded surfaces were studied using X-ray photoelectron analysis. For all studied alloys, the microstructure consisted of α matrix, which was strengthened by β phase. The highest and the lowest values of the β phase’s volume fraction were recorded for TC21 and Ti-Al-Nb alloys, respectively. The uniform corrosion rate and pitting corrosion resistance (R_pit) of the studied alloys were enhanced following the sequence: Ti-6Al-7Nb < Ti-6Al-4V << TC21. The corrosion resistance of Ti-Al-Nb alloy approached that of pure Ti. The obvious changes in the microstructure of these alloys, together with XPS findings, were adopted to interpret the pronounced variation in their corrosion rates.

Quantum physics through the lenses of Bayesian statistics consider probabilities to be degree of believes or knowledge and subjective. A Bayesian derivation of the probability density function in phase space is presented. The entropy proposed by Geiger and Kedem \cite{GeiKed2022a,GeiKed2022b} in phase space is expanded to define quantitatively interference and entanglement. Comparisons between each of these two quantities and the entropy are made. A brief presentation of entanglement in phase space to the spin degree of freedom and to mixed states completes the work.

Attitudes and behaviours towards the natural environment have been extensively studied in certain cultural settings during the last 40 years. In education, the teacher's ability to grasp the fundamentals of an academic subject may define his or her own attitudes towards that discipline; certainly the reverse is also valid. The correlations between affective and cognitive domains appear to play a significant role in teaching-learning dynamics. In this study we seek to assess whether the affective posture towards school sciences of a cohort of teachers in rural communities shows an association with their cognitive competence in the disciplines. The results of this study provide evidence that there is a statistically significant correlation between the cognitive and affective domains for in-service teachers. The affective domain, therefore, could serve as a predictor for cognitive competency and self-efficacy expectancies with respect to both content and career fulfilment.

1) Background: We analyzed the corpus of three geoscientific journals to investigate if there are enough locational references in research articles to apply a geographical search method, on the example of New Zealand. 2) Methods: Based on all available abstracts and all freely available papers of the New Zealand Journal of Geology and Geophysics, the New Zealand Journal of Marine and Freshwater Research, and the Journal of Hydrology, New Zealand, we searched title, abstracts and full texts for place name occurrences that match records from the official Land Information New Zealand (LINZ) gazetteer. We generated ISO standard compliant metadata records for each article including the spatial references and make them available in a public catalogue service. This catalogue can be queried for articles based on authors, titles, keywords, topics as well as by spatial reference. We visualize the results in a map to show which area the research articles are about. 3) Results: We outline the methodology and technical framework for the geo-referencing of the journal articles and the platform design for this knowledge inventory. The results indicate that the use of well-crafted abstracts for journal articles with carefully chosen place names of relevance for the article provides a guideline for geographically referencing unstructured information like journal articles and reports in order to make such resources discoverable through geographical queries. 4) Conclusion: This approach can actively support integrated holistic assessment of water resources and support decision making.

This paper focuses on determining the State of Charge (SOC) of lithium-ion batteries when operating and the influence the State of Health (SOH) has on SOC determination. The paper studies the effects of the discharge rate on the battery performance and how it modifies the evaluation of the SOC. The article also analyzes the effects of battery aging on the determination of SOC. The online determination of SOC in lithium-ion batteries uses the linear behavior of battery discharge and how the discharge rate modifies the battery voltage slope. The paper develops a simple algorithm that relates the SOC of the battery with the online battery voltage. The proposed measurement method uses a very short controlled discharge at a specific rate that avoids unexpected interferences with the current operation of the battery during charge or discharge. We conducted a simulation process to evaluate the evolution of the SOC in Li-ion batteries for different operating stages. Experimental tests validate the proposed methodology, showing a close agreement between theoretical values and experimental results with 98% accuracy. The paper also deals with the determination of the aging factor in lithium batteries as a critical parameter to calculate the SOC. The method determines the aging factor using specific simulation for this goal. The results are compared to values obtained in an experimental test within high agreement (>93%). The proposed model applies to almost any lithium battery and is validated for a wide range of Battery State of Health, up to 50%, within accurate prediction, higher than 90%.

The present research aimed to identify if consumption values influence the attitudes of Millennials who intend to purchase organic products. The research was quantitative, with a correlational scope and a cross-sectional design, and it was conducted on 509 Peruvian millennials. A questionnaire consisting of 23 questions was administered, and responses were quantified using a five-point Likert scale. The results were processed through an Exploratory Factor Analysis (EFA), Confirmatory Factor Analysis (CFA), and Structural Equation Modeling (SEM) conducted using Statistical Package for Social Sciences 24 and AMOS 24. The study identified that environmental attitudes of Millennials do influence their intentions to purchase organic products, and the antecedents of these attitudes are functional and social values, whereas emotional, conditional, and epistemic values do not. The study confirmed that consumption values, either as a second-order variable or as a single construct, do not influence the attitudes of Millennials who intend to purchase organic products, thus confirming that these dimensions should be measured independently.

The rapid growth of the elderly population is a major global demographic and social issue. Unfortunately, there is a shortage of pension plans and social se-curity programmes for this population in developing countries which has severe consequences for their quality of life and planetary health (PH) wellbeing. In this article, we aimed to better understand the pension systems in Ghana, Pakistan, and Myanmar, by reviewing the official government materials (such as pension reports) and published literature. We observed several policy implementation gaps and inequity in pension schemes for older people, specifically for informal and private sector workers. Considering the size of formal versus informal economies and the level of development index of each country, we suggest a wide variety of options in pension policies, financing, designing cash benefits and pension payments to cover all older citizens. This article addresses an unmet need of the elderly people, their wider environmental and economic sustainability to ensure social justice and resource utilization. The governments of developing countries should embrace and establish unique, inclusive, and friendly policies encompassing the informal sector to warrant older adults’ functional and planetary wellbeing with dignity and honor.

Selenium nanoparticles (SeNPs) has higher bioavailability and safety than inorganic selenium, and was widely used in medical, agricultural, nutritional supplements, and antibacterial fields. The present study screened a strain L11 producing SeNPs from a selenium rich dairy cow breeding base in Hubei Province, China. The strain was identified as Bacillus subtilis through physiological, biochemical, and molecular biology analysis. Through optimization of cultivation conditions, the optimal cultivation parameters for L11 to produce SeNPs were pH=6, cultivation temperature of 37 °C, 4 mmol/L Na2SeO3, and cultivation for 48 hours. XPS, SEM-EDS, and TEM were used to verify that the Se particles produced by L11 are SeNPs with diameters ranging from 50 to 200 nm. The combination of protein analysis of different cell components and TEM analysis showed that L11 mainly produces SeNPs through the transformation of the cell's periplasmic space, cell membrane, and cell wall. Adding L11 SeNPs complex to sheep feed can significantly enhance the antioxidant activity and immunity of sheep, and increase the Se content in the neck muscles, liver, and spleen tissues.

This study examines the influences of live streaming servicescape on Chinese consumers' luxury purchase intention. Interestingly, for the sample without luxury purchase experience, the mediating effect of the perceived value of luxury goods is significant but effect of consumer trust is not. For the sample with luxury purchase experience, the result of mediating effect is just the opposite. The interaction between conspicuous consumption and live streaming servicescape plays a certain role in regulating the perceived value of luxury goods. These results show that luxury brands can adopt innovation in the live streaming servicescape for different types of consumers to promote live streaming marketing. This study enriches the servicescape theory of live streaming.

A survey of the trends in metal-ligand coordination and hydrogen bonding has been carried out on complexes of singly deprotonated cyanuric acid CY− and alkaline earth metals, synthesised from aqueous solution and characterised by X-ray crystallography. Involvement of cyanurate in the metal coordination increases from Mg through Ca and Sr to Ba relative to coordination by water, in parallel with the increasing ionic radius and coordination number. The incidence of bridging of metal centres by both water and cyanurate also increases in this series. The Mg complex contains hexaaqua-coordinated cations, uncoordinated CY− anions, and additional water molecules. Ca and Sr complexes feature polymeric chains of coordinated metal ions, the Ca complex with uncoordinated anions and the Sr complex with all potential ligands coordinated. The Ba complex has a two-dimensional coordination network. Extensive hydrogen bonding plays a key role in generating a three-dimensional network in all four structures. The competition between cyanurate and water for coordination to the alkaline earth metal cations, and that between coordination and hydrogen bonding propensities of the cyanurate anion, appear to be finely balanced, with the structural outcomes depending on the relative sizes and degrees of hardness of the four cations of the group.

We studied the weekly number and the growth/decline rates of COVID-19 deaths in the period October 31, 2022 – February 9, 2023, in Italy, finding that that COVID-19 winter wave reached its peak during the three holyday weeks extending from December 16, 2022 to January 5, 2023, and it was definitely trending downward, returning to the same number of deaths of the end of October 2022, in the week February 3 – 9, 2023. During this period of fifteen weeks, that wave caused a number of deaths as large as 8,526. Its average growth rate was +7.89% deaths per week (ten weeks), while the average weekly decline rate was -12.32% (five weeks). Currently, Italy is experiencing a new COVID-19 wave, with the latest six weekly bulletins (October 26, 2023 – December 14, 2023) showing that the deaths have climbed from 148 to 322. The weekly growth rate has risen by +14.08% deaths, on average. In the hypothesis that this 2023-2024 wave have a duration similar to that of 2022-2023, with: i) a comparable extension of both the growing period and of the decline period and ii) similar growth/decline rates, a prediction can be cast regarding the number of COVID-19 deaths in the period November 2023 - January 2024. They could reach the amount of 4100-4200

Based on the theory that certain geological fault zones surpass the influence of other abiotic and biotic site factors for mound-building red wood ants (Formica rufa group), an area northwest of Tuttlingen with extremely high ant density was systematically surveyed, taking into account official geological maps. Indicators of active fault zones were recorded. These were additionally examined in a model area using a high-resolution digital terrain model (DTM 1-meter). The study area is located in the Swabian Jura at the western edge of the Albstadt shear zone, where recent seismic activity is documented by frequent earthquakes. The earthquakes are considered to be the cause of gas permeability in the strike-slip faults, around which the clustered nesting sites were mapped. More than 2900 nests of the Formica rufa group were mapped and their site conditions analysed in different geomorphological positions. In addition to recording forestry site conditions, a geological classification was carried out, as well as an analysis of soil gases/mofettes in areas with the highest nest densities. The correlation between forestry data and nest sites did not reveal a consistent pattern. In contrast, the relationships with gas-permeable strike-slip faults, though predominantly covered with Quaternary sediments, could be identified through CO₂- and CH₄-rich gas emissions, mofettes, and doline features. The interpretations were complicated due to different mapping ages and signatures of the geological maps. Fortunately, this issue could be analysed and evaluated in a sub-area with mappings from 1936/71 and 1995 regarding presumed or confirmed fault trajectories. New insights were gained regarding the relationships between Formica nest sites, gas-permeable faults, and groundwater levels on narrow mountain ridges with steep relief. Here, the lateral emission of CO₂ depends on the groundwater level and does not occur vertically directly above the fault. C- and H-isotope data of CO₂ and CH₄ do not show a consistent source. While methane is mainly derived from biological production by Archaea in the upper crust and in swamp areas, CO₂ mostly originates from the mantle. The results of the investigations revealed that a multitude of geological and ecological factors must be considered for the interpretation of the occurrences of Formica sites northwest of Tuttlingen. These factors confer a distinct originality to this region, contributing not only to an enhanced understanding of site conditions but also furnishing information regarding environmentally relevant gas emissions.

This study mainly explores the effect of policy formalism, equipment insufficiency, covid-19 fear and job insecurity on construction workers’ insomnia during the epidemic. The main contribution of this article is to introduce policy formalism into the exploration of the causes of insomnia among construction site workers during the epidemic. This study collected 733 valid samples of construction site workers. We tested the established hypotheses using confirmatory factor analysis and structural equation modeling. The research results found that equipment insufficiency positively affects Covid-19 fear. Policy formalism and Covid-19 fear positively affect job burnout. Social support negatively affects job burnout. Job burnout and job insecurity positively affect insomnia.

This study assesses the feasibility of hepatitis B and C elimination, using an analysis of trends of epidemiology data (1990-2019) from the global burden of disease. Joinpoint regression analysis was used to identify significant changing points in trends of Age-standardizes Prevalence Rate (ASPR) and Age-standardizes Mortality Rate (ASMR) and to estimate the annual percentage changes (APC) and the average annual percentage changes (AAPC) for the period. Sociodemographic Index (SDI) was used to analyze trends between countries. The total percentage change of the ASPR (2019/1990) was -31.4% and -12.8% for HBV and HCV worldwide respectively, the rate ratio (HBV/HCV) was 2.5. Mortality has decreased for HBV but not for HCV. The total percentage change for the ASMR (2019/1990) was -26.7% and 10.0%, for HBV and HCV respectively. While ASMR of HBV decreased, HCV increased during this period. The percentage change in ASMR of HBV was highest in countries with high-middle SDI and lowest in countries with high SDI. For HCV, the percentage change in ASMR was highest in countries with High SDI (increase) and only in countries with low SDI decreased. The global HBV and HCV rates have fallen with different AAPC associated with the SDI. Despite the advances, there is still a long way forward to achieve the 2030 elimination goals. An important challenge is related to finding a way to speed up the yearly rate at which the decline is happening.

The construction of 22 dams on the Euphrates has reduced the flow of this river, changed the hydrology and destroyed the ecosystem. In order to understand the effect of extreme management on water, 4 coastal points from the Euphrates catchment area were selected to investigate the dynamics of the water level. Using the Cadmium method, the radius of each point was calculated to be 140 meters to study the NDWI index and satellite monitoring. 546 Landsat 8 OLI/TIRS satellite images from 2013 to 2022 were used. The analysis showed that the water level of the Euphrates in the fourth coordinate is directly related to the data of the first and third coordinates and the dynamics of the water level in the fourth coordinate is 3.6 to 4.2 percent of the first coordinate and another 5.2 to 5.9 percent is affected by the third coordinate. Is. Also, the data from August 2013 to 2022 were analyzed. The results showed that the correlation coefficients of the data related to the first coordinates are related to the third and fourth coordinates. It was proved that fluctuations in the first coordinate led to 27% change in the third coordinate in the months of August. Also, the changes in the first point caused 18-19.8% change in the dynamic level of water in the fourth point, and 22.5% of the changes in the water level in the fourth coordinate were affected by the third point.

Verminosis causes great damage to the producer, with reduced milk production and decreased development of young animals. The use of bioproducts are an alternative to control worms. This study evaluated the effects of oral administration of one commercial formulations, based on the fungus Duddingtonia flagrans (Bioverm®) and experimental formulations D. flagrans associated with Pochonia chlamydosporia, on the control of worms in naturally infected cattle on February pasture to October 2021. Eighteen Holstein x Zebu cattle were divided into groups of six animals (group 1 Bioverm®, group 2 Association and control), separated into paddocks naturally infected with helminth larvae (L3). The parasite load was by means of fecal samples and pasture collection to determine L3 infestation. The study demonstrated low recovery of L3 in the pasture due to low rainfall during the experiment. The EPG was lower in groups 1 and 2 compared to the control in April, May and July, while in March the values were lower only in treatment 1 compared to the control. Individual or combined administration of fungal products reduced the presence of eggs and larvae in pastures at certain months of the year, indicating their effectiveness in the strategic control of gastrointestinal parasites in cattle.

The objective of the current study is to evaluate the effects of nitrogen rate N on tree growth, fruit yield and quality of clementine Nules variety, budded on Flhorag and Carrizo citrange rootstocks, grown on clay soils at the Experimental station of Sidi Allal Tazi, INRA Morocco, over five seasons. The experiment has been carried out in a split-plot design with three replications, including the nitrogen doses as the main plot and rootstock the subplot. Three fertilization treatments of the rates of N (g/tree) (T0: control (native nutrient), T1: 270, T2: 540 in g/tree) and 135 P2O5, 270 K2O g/tree have been applied to citrus trees in field conditions. The study found that nitrogen rate and rootstock genotype had significant effects on vegetative growth, yield, and fruit quality of Nules clementine. As N rate increased, vegetative growth improved significantly, with the trees grafted on Carrizo citrange and fertilized with T2 (540 N g/tree) showing the best results. A strong positive correlation was also observed between canopy volume and fruit yield for both rootstock genotypes. Carrizo citrange proved to be a more efficient rootstock for Nules variety than Flhorag, with higher yield and better fruit quality. As a conclusion, the recommended NPK rate for obtaining an optimal yield and good fruit quality of Nules clementine fruits was 540 N-135 P2O5-270 K2O g/tree/year under Sidi Allal Tazi–Gharb (Morocco) conditions.

Changing climate conditions and rapidly increasing carbon dioxide emissions have severely affected the global ecosystem and world economy. Governments around the world have paid attention to these resulting challenges and enacted many policies to reduce environmental pollution and carbon dioxide (CO2) emissions. This study aimed to determine and understand the relationship between innovation, foreign direct investment, economic growth, renewable consumption and CO2 emission in Vietnam. Information was collected annually based on the annual data of the General Statistics Office of Vietnam and World Bank from 2000 to 2022. Data processing was conducted using the STATA 17.0 software. The innovation affects Vietnam’s environmental pollution. Innovation positively affect environmental pollution in Vietnam; if Vietnam’s innovation were to increase by 1%, CO2 emissions would increase by 0.68%. The empirical research results of this study also show that renewable energy consumption has a negative effect on environmental pollution in Vietnam; if renewable energy were consumed at a 1% increase, CO2 emission would decrease by 0.51%. In addition, FDI inflows and economic growth have strongly positive affecting to environmental pollution; if Vietnam’s FDI inflows were to increase 1%, CO2 emissions would increase 1.39%; if Vietnam’s GDP increase 1% then CO2 emission would increase 1.26%. This paper also provides some recommendations that can assist Vietnam in developing a green and sustainable economy in the technology revolution 4.0 to achieve the United Nations Sustainable Development Goals (SDGs) over a long-term period.

In this research, assume a SuperHyperGraph. Then a ``Failed SuperHyperClique'' $\mathcal{C}(NSHG)$ for a neutrosophic SuperHyperGraph $NSHG:(V,E)$ is the maximum cardinality of a SuperHyperSet $S$ of SuperHyperVertices such that there's a SuperHyperVertex to have a SuperHyperEdge in common. Assume a SuperHyperGraph. Then an ``$\delta-$Failed SuperHyperClique'' is a \underline{maximal} Failed SuperHyperClique of SuperHyperVertices with \underline{maximum} cardinality such that either of the following expressions hold for the (neutrosophic) cardinalities of SuperHyperNeighbors of $s\in S:$ $~|S\cap N(s)| > |S\cap (V\setminus N(s))|+\delta,~|S\cap N(s)| < |S\cap (V\setminus N(s))|+\delta.$ The first Expression, holds if $S$ is an ``$\delta-$SuperHyperOffensive''. And the second Expression, holds if $S$ is an ``$\delta-$SuperHyperDefensive''; a``neutrosophic $\delta-$Failed SuperHyperClique'' is a \underline{maximal} neutrosophic Failed SuperHyperClique of SuperHyperVertices with \underline{maximum} neutrosophic cardinality such that either of the following expressions hold for the neutrosophic cardinalities of SuperHyperNeighbors of $s\in S:$ $~|S\cap N(s)|_{neutrosophic} > |S\cap (V\setminus N(s))|_{neutrosophic}+\delta,~ |S\cap N(s)|_{neutrosophic} < |S\cap (V\setminus N(s))|_{neutrosophic}+\delta.$ The first Expression, holds if $S$ is a ``neutrosophic $\delta-$SuperHyperOffensive''. And the second Expression, holds if $S$ is a ``neutrosophic $\delta-$SuperHyperDefensive''. A basic familiarity with Neutrosophic Failed SuperHyperClique theory, SuperHyperGraphs theory, and Neutrosophic SuperHyperGraphs theory are proposed.

Earthworm invasions often reduce biodiversity and affect the ability of ecosystems to perform ecosystem functions. Over the past few decades, European lumbricide species have spread widely in natural habitats in Western Siberia, without completely displacing the native species. The aim of the present experiment is to study the survival, reproductive potential, vertical distribution, abundance, and biomass of Aporrectodea caliginosa and Lumbricus rubellus invasive for the region and the native species Eisenia nordenskioldi and their influence on each other. For this purpose, winter and vegetation experiments were conducted in mesocosms simulating the real situation of invasions in the same communities on the same types of soils with the same amount and composition of litter. The authors found that the native species was significantly inferior to A. caliginosa in reproduction rate, number of offspring, and final biomass, but had an advantage over L. rubellus. The native species was positively influenced by the presence of A. caliginosa. In the experiment, there was a significant rejuvenation of the populations of the studied species, an increase in abundance and relative mass under interaction conditions compared to mono variants. The native species had advantages over the invasive species in terms of winter survival. The natural volume of litter used in the experiment was insufficient for L. rubellus. According to the results of the experiment, it can be assumed that the spread of L. rubellus will continue to be limited to non-freezing biotopes rich in organic matter. A. caliginosa will spread in natural communities and agrocenoses of Western Siberia.

China’s rural e-commerce has been developing rapidly. Taobao Villages are combination of e-commerce and rural industries. When rural e-commerce coverage evolves from Taobao village to Taobao town, the scale of industrial clusters has been expanding synchronously. This paper investigates flower and seedling industrial cluster in Xinhe Town, Yanji Town and Miaotou Town of Shuyang County, China, and conducts the econometric analysis of the expansive determinants of flower and seedling industrial cluster of Taobao Villages. An effective sample of 263 was obtained through a face-to-face survey of e-merchants of flower and seedling in the Shuyang County of Jiangsu Province. Bases on the structural equation modeling, series of test results show that the data can be used to calculate the path regression. The outcomes shows that creation of e-merchants of flower and seedling, integration of e-commerce platform, supply chain friendliness, involvement of e-commerce service providers, and governmental policy guidance are driving expansion of flower and seedling industrial cluster together, moreover, the five forces interact with each other. This implies that expansion of flower and seedling industrial cluster is a systematic process, each stakeholder needs to pay attention to the role of other forces, and five forces achieve a balanced situation in the cluster.

The perceived risk of being infected at work (PRIW) with COVID-19 represents a potential risk factor for workers during the current COVID-19 pandemic. In line with the job demands-resources (JD-R) model applied to safety at work, in this longitudinal study we propose that PRIW can be conceptualized as a job demand, whereas communication (i.e., the exchange of good-quality information across team members) can be conceived as a job resource. Accordingly, we hypothesized that PRIW at Time 1 (T1) would positively predict psychophysical strain at Time 2 (i.e., four months later). Furthermore, we hypothesized that communication at T1 would negatively predict psychophysical strain at T2. Overall, 297 workers took part in the study. The hypothesized relationships were tested using multiple regression analysis. Results supported our predictions: PRIW positively predicted psychophysical strain over time, whereas communication negatively predicted psychophysical strain over time. Also, results did not change after controlling for age, gender, and type of contract. Overall, this study suggests that PRIW and communication can be considered as a risk and a protective factor for work-related stress, respectively. Hence, to promote more sustainable working conditions, interventions should encourage organizations to optimize the balance between job demands and job resources related to COVID-19.

The results of an LA-ICP-MS U-Pb dating and Hf isotope study of zircon crystals separated from small eclogite xenoliths found in Devonian kimberlites within the Prypyat horst, Ukraine, are reported. The studied area is located in the Central Belarusian Suture Zone, which represents a Paleoproterozoic belt extending along the boundary between the Sarmatian and Fennoscandian segments of the East European Platform. Four laser ablation sites on two zircon grains yielded Paleoproterozoic U-Pb ages between 1954 ± 24 Ma and 1735 ± 54 Ma. In contrast, three of four Hf sites revealed negative εHf values and Paleoarchean to Mesoarchean model ages, excluding the possibility that the eclogite xenoliths represent segments of a Paleoproterozoic subducted slab or younger mafic melts crystallized in the subcontinental lithospheric mantle. A single laser ablation Hf spot yielded a positive εHf value (+3) and a Paleoproterozoic model age. Two models for eclogite origin can be proposed. The first foresees the extension of the Archean lower-crustal or lithospheric roots beneath the Central Belarus Suture Zone for over 200 km from the nearest known outcrop of Archean rocks. The second model is that the Central Belarus Suture Zone represents a rifted-out fragment of the Kola-Karelian craton that was accreted to Sarmatia before the actual collision of these two segments of Baltica.

This research is aimed at evaluating two different scenarios, firstly, appraising the impacts of employing the concepts of Total Quality Management (TQM) to the construction projects in Saudi Arabia. The results of the study were obtained through utilization of a descriptive analytical approach, where 300 questionnaires were distributed to engineering firms and companies with a response rate of 200 questionnaires, hence achieving the study sample for this research. The data gathered was analyzed by applying the Statistical Package for Social Science (SPSS) program and calculating the Relative importance index (RII) and the mean values. From the research conducted, the outcomes showed that the management’s ability to commit using TQM while applying BIM obtained a relative importance of (0.717), while the relative importance for the management’s ability to commit using TQM without the application of BIM is (0.552). The results showed that construction projects in Saudi Arabia still sustain setbacks from applying TQM concepts and suffer from the lack of administrative, scientific and technical applications. In a second scenario, a hybridized support vector regression (SVR) Harris-hawks optimization (HHO) (i.e., SVR-HHO) were used to predict the TQM. The performance accuracy of the models was checked through three different evaluation metrics namely; mean square error (MSE), correlation co-efficient (CC) and Nash-Sutcliffe efficiency (NSE). the hybridized emerging SVR-HHO outperformed the other two data driven approaches in both the training and testing stages based on the employed evaluation metrics. Overall, the obtained results showed that both the machine learning and metaheuristic approaches were capable of predicting TQM.

Radiolabelled tracers targeting the prostate-specific membrane antigen (PSMA) have become important radiopharmaceuticals for the PET-imaging of prostate cancer. In this connection we recently developed the fluorine-18 labelled PSMA-ligand [¹⁸F]PSMA-1007 as next generation radiofluorinated Glu-ureido PSMA inhibitor after [¹⁸F]DCFPyL and [¹⁸F]DCFBC. Since radiosynthesis so far was suffering for rather poor yields novel procedures for the automated radiosyntheses of [¹⁸F]PSMA-1007 have been developed. We herein report on both the two-step and the novel one-step procedures, which have been performed on different commonly used radiosynthesisers. Using the novel one-step procedure the [¹⁸F]PSMA-1007 was produced in good radiochemical yields ranging from 30-70 % and synthesis times less than 55 minutes. Furthermore, upscaling to product activities up to 50 GBq per batch was successfully conducted. All batches passed quality control according to European Pharmacopoeia standards. Therefore, we were able to disclose a new, simple and at the same time high yielding production pathway for the next generation PSMA radioligand [¹⁸F]PSMA-1007. Actually it turned out that the radiosynthesis is as easily realised as the well-known [¹⁸F]FDG synthesis and thus transferable onto all currently available radiosynthesisers. Using the new procedures, clinical daily routine can be sustainably supported in-house even in larger hospitals by a single production batch.

Synergistic effects between reactions, reagents and catalysts can lead to minor heats of reaction and occur as an inherent result of multi-component reactions (MCRs) and their extensions. They enable syntheses to be performed at a low energy level and the number of synthesis steps to be drastically reduced in comparison with ‘classical’ two-component reactions. The very high potential for variability, diversity and complexity of MCRs additionally generates an extremely diverse range of products, thus bringing us closer to the aim of being able to produce tailor-made and extremely low-priced materials, drugs and libraries.

Electric mobility is a global trend and necessity, with electric and solar boats offering a promising alternative for transportation electrification and carbon emission reduction, especially in the Amazon region. This study analyzes the system of a solar boat from the SIMA project, to be implemented at UFPA, using MATLAB software for modeling. The Simulink tool was utilized to model the system, focusing on operational parameters such as module voltage, converter voltage, and speed. Results indicate that the solar boat's operational cost is significantly lower compared to a similar internal combustion model, considering diesel's high consumption and cost. The environmental impact is also reduced, with nearly 72 tons of CO2 emissions avoided annually, thanks to Brazil's renewable energy matrix. Simulations confirmed the project's parameters, demonstrating the efficiency of digital twin technology in monitoring and predicting system performance. The study underscores the importance of digital twins and renewable energy in promoting sustainable transportation solutions, advocating for the replication of such projects globally. Future research should focus on further advancing digital twin applications in electric mobility to enhance predictive maintenance and operational efficiency.

In the present study, we implemented species distribution models (SDMs) to determine the potential invasive distribution range of a cichlid fish, Nile tilapia, Oreochromis niloticus, in a very sensitive inland water system in the southeastern Arabian Peninsula where it is now established and spreading. By using the “Biomod2” package, and the latest CMIP6 climate data, four single species distribution models and EM were built, and the results were evaluated by operating characteristic (ROC) and the true skill statistic (TSS). Based on the relative importance of climate factor analysis the mean diurnal range and precipitation seasonality were useful predictors of habitat suitability for O. niloticus. The response curve analysis indicated that the presence probability of O. niloticus decreased with increasing mean diurnal range and decreasing precipitation seasonality. The suitable distribution ranges for O. niloticus in the studied area were mainly distributed in the northeast of this region. The ensemble model results specified a significant impact of climate change on O. niloticus distribution, so highly suitable areas for this species will be reduced, while areas with low to moderate suitability increase slightly or remain unchanged. Based on the available data, Nile tilapia fulfills all four criteria to be considered as an invasive species: colonization in a new area, direct or indirect impacts of anthropological activity on its distribution range, geographical discontinuity between its native area (Africa) and the Arabian Peninsula (remote dispersal), and finally, its successful breeding in situ without human assistance resulting establishment of this biopollutant. Species distribution modeling provides insights into the factors that can reduce the risks and negative impacts of this biological pollutant on aquatic ecosystems of the southeastern Arabian Peninsula which harbors about 22 recognized fish species in 16 genera, 10 families, seven orders, and a class including 20 natives (seven endemic) species.

As an important means of controlling the spread of cities, large-scale urban green belts have been widely used in the planning and construction of green space systems in various mega-size cities around the world. In previous studies, there has been more research on the overall isolation effect of green belts, while there has been less research on changes in their internal structure. There have been more perspectives on the land-use change (LUC) caused by urban expansion, and less systematic research on the dual driving factors of LUC. In this paper, we constructed a multi-dimensional index system to measure the "contraction-expansion" mechanism of land use in the overlapping vegetation areas of large green belts under the dual influence of urban expansion and urban greening, from the perspectives of quantity, space, and connectivity during different construction periods. Taking the boundary of two green belts in Beijing as an example, we hope to provide scientific support for the construction and ecological protection of Beijing's green belts.

This study examines the Willingness-To-Pay (WTP) of consumers and the determinants of eco-labeling for the organic cocoa powder produced in the Dong Nai UNESCO Biosphere Reserve (DNBR), Southern Vietnam. Eco-labels are designed according to Tiers of eco-labeling for biosphere reserves (BR) introduced by UNESCO include BR Destination (Tier 1), BR Quality Label (Tier 2), and Professional Certification Label (Tier 3). Questionnaires are delivered to 203 customers in the DNBR and nearby places, such as Dong Nai and HCMC. This study employs a hybrid approach using descriptive statistics, ANOVA test, and Partial Least Squares Structural Equation Model (PLS-SEM). The results indicate that gender and educational level have a positive effect on consumers' preferences. Customers are willing to pay more for cocoa powder with an eco-label than one with an organic label. Perceived food safety and product knowledge lower customers’ WTP, whereas agricultural environment and pricing concerns increase it. Tier 2 is suggested for labeling cocoa powder in the DNBR. The DNBR Management Board, together with the federal and provincial governments, should all follow a similar certification process. Increased eco-label awareness is crucial for the future of environmentally responsible shopping and responsible business practices.

Deficit schizophrenia is characterized by leaky tight and adherens junctions and bacterial translocation. Here we examine whether (deficit) schizophrenia is accompanied by leaky paracellular, transcellular and vascular barriers in the gut and blood brain barriers. We measured IgA responses to occludin, claudin-5, E-cadherin and β-catenin (paracellular pathway, PARA), talin, actin, vinculin and epithelial intermediate filament (transcellular pathway, TRANS) and plasmalemma vesicle-associated protein (PLVAP, vascular pathway) in 78 schizophrenia patients and 40 controls. IgA responses to claudin-5, E-cadherin and β-catenin, the sum of the four PARA proteins and the ratio PARA/TRANS were significantly higher in deficit schizophrenia than in non-deficit schizophrenia and controls. A large part of the variance in PHEMN (psychosis, hostility, excitation, mannerism and negative) symptoms, psychomotor retardation, formal thought disorders, verbal fluency, word list memory, word list recall and executive functions was explained by the PARA/TRANS ratio coupled with plasma IgA responses to Gram-negative bacteria, IgM to malondialdehyde, CCL-11 (eotaxin), IgA levels of the ratio of noxious to more protective tryptophan catabolites (NOX/PRO TRYCATs) and a plasma immune activation index. Moreover, IgA levels to Gram-negative bacteria were significantly associated with IgA to E-cadherin, β-catenin and PLVAP, while IgA levels to claudin-5 were significantly predicted by IgA to E-cadherin, NOX/PRO TRYCAT ratio, Gram-negative bacteria and CCL11. The phenomenology of the deficit syndrome is to a large extent explained by the cumulative effects of lowered natural IgM, breakdown of the paracellular and vascular pathways, increased bacterial translocation, peripheral immune-inflammatory responses and indices of BBB breakdown.

Malaria is a long-standing disease and one of the top life-threatening diseases, yet its treatment has not changed, while the world has already embraced the Fourth Industrial Revolution (4IR). A wave of research on digitizing monitoring mechanisms of such a deadly disease has surfaced. Automated malaria screening is one of the detection processes which are gaining popularity in the research domain. However, the process needs to be coupled with other processes aiming a nationally or regionally contextualised malaria monitoring system. This paper proposes a digital malaria monitoring system in the context of an African country or region. One advantage of such a digital system is that is enables a novel disease spread forecasting model based on the dynamics of different malaria types. The architecture of the diagnosis system is described, and the disease spread model is mathematically modelled in terms of a SPITR (Susceptible- Protected- Infected-Treated- Recovered) epidemic model which is further analysed. The forecasting model is expressed and analysed whereas experiments are conducted using a Monte Carlo simulation method. The design of the monitoring system has inspired how predictions can be made in the complex cases such as mixed infections. Results show that reinforcing the model parameter makes a significant improvement on the disease prediction.

Although monitoring and observing insect pest populations in the fields is essential in crop management, it is still a laborious and sometimes ineffective process. High infestation levels may diminish the photosynthetic activity of soybean plants, affecting their development and reducing the yield. An imprecise decision making in integrated pest management program may lead to an ineffective control in infested areas or the excessive use of insecticides. In order to reach a more efficient control of arthropods population it is important to evaluate the infestation in time to mitigate its negative effects on the crop and remote sensing is an important tool for monitoring. It was proposed that infested soybean areas could be identified, and the arthropods quantified from non-infested areas in a field by hyperspectral remote sensing. Thus, the goals of this study were to investigate and discriminate the reflectance characteristics of soybean non-infested and infested with Bemisia tabaci using hyperspectral remote sensing data. Therefore, samples of infested and non-infested soybean leaves were collected and transported to the laboratory to obtain the hyperspectral curves. The results obtained allowed to discriminate the different levels of infestation and to separate healthy from whitefly infested soybean leaves based on their reflectance.

Background: Filamentous fungi are an emergent cause of severe infections in immunocompromised patients. Timely and accurate identification is crucial to initiate appropriate therapy. Traditional identification methods are time-consuming, labor-intensive, and operator-dependent. Ma-trix-assisted laser desorption/ionization-time-of-flight (MALDI-TOF) mass spectrometry is a rapid and easy-to-perform identification method. This study evaluates the effectiveness of a commercial MALDI-TOF MS platform to identify filamentous fungi in a routine laboratory. Material and Methods: We included 67 fungal isolates from 35 species/species complexes within 15 genera, confirmed in mycology reference laboratories. 33 were from clinical samples and 34 from strain collections. The study used the VITEK MS system (v3.2.0 database), after sample extraction by VITEK MS Mould Kit. Results were classified into categories: ‘correct species’, ‘correct species complex’, ‘correct genus’, ‘incorrect identification’, and ‘no identification’. We also evaluated the practicality of the kit. Results: VITEK MS correctly identified 91.0% of isolates (58.2% to species, 29.9% to species complex, and 1.5% to genus level). In 82%, the result matched the species/species complex identified by reference methods. No misidentifications were observed. The kit was rapid and easy to use. Conclusion: The VITEK MS system showed a high capability to accurately identify filamentous fungi in a routine laboratory.

LuBO3 crystallizes in the calcite type (CaCO3) structure and is a widely applied inorganic host for luminescent materials and scintillators. Even though many scientific works have been published concerning the optical properties of rare earth doped LuBO3, so far, no study of the emission spectra as function of the excitation energy of such orthoborates has been conducted. Therefore, this work deals with the photoluminescence of RE doped LuBO3 with RE = Ce3+, Eu3+, Gd3+, or Tb3+, while an emphasize is laid on the energy dependence of these four luminescent compounds.

The article presents the operation of the automatic pine sawn timber inspection system, which was developed at the Woodinspector company and offered commercially. The vision inspection system is used to detect various wood defects, including knots, blue stain, and mechanical damage caused by worms. Blue stain is a defect that is difficult to detect based on the color of the wood, because it can be easily confused with wood defects or dirt that do not impair its strength properties. In particular, the issues of detecting blue stain in wood, the use of artificial neural networks and improving the operation of the system in production conditions were discussed.

\abstract{The existence of vorticies is well known in fluid mechanics and particularly in turbulence theory. In the context of the millennium problem of the Clay Institute on the existence (or not) of Global solutions in time of the Periodic Navier Stokes equations (PNS) results are now proposed to confirm that Global solutions do not exist in the general case of PNS defined on $\mathbb{T}^3$. This corresponds to part ($D$) proposition in the Navier Stokes problem as posted by C.Fefferman. Recent work has shown that for the Euler equations defined on the 3-Torus there exists a H\"older continuous solution for the third component of velocity $v_3$ at the center of each cell or cube of the 3-Torus Lattice. It has also been determined that as the kinematic viscosity changes from the corresponding value at $\nu=0$ to the fully viscous case for the Periodic Navier Stokes equations (PNS) at the value $\nu=1$ the solution reaches a peak ($\frac{\partial v_3}{\partial y_3} = 0$ ) in $y_3$. (third component of $\vec{r}=(y_1,y_2,y_3)$ in Cartesian co-ordinates) Here in the viscous case there exists a dipole which is not centered at the center of the cell of the Lattice. This immediately implies that since the dipole by definition has an equal in magnitude positive and negative peak in the third component of velocity, then the dipole Riemann cut-off surface is covered by a closed surface which is the sphere $\|\vec{r}\|=1$ and where a given cell of dimensions $[-1,1]^3$ is circumscribed on a sphere of radius $1$. For such a closed surface containing a dipole it necessarily follows that the flux at the surface of the sphere of $v_3$ wrt to surface normal $\vec{n}$ is zero including at $y_i, i=1\dots 3$ is zero at the points where the surface of sphere touches the cube walls. At the finite time singularity on the sphere a rotation boundary condition is deduced. Here $\frac{\partial v_3}{\partial \vec{n}}= \vec{n}\cdot \nabla v_3$. Also a boundary condition on the sphere shows rotation of sphere. Finally as a result, on the sphere a solution for $v_3$ is obtained which is proven to be H\"older continuous and it is proven that it is possible to extend H\"older continuity on the sphere uniquely to all of the interior of the ball.}

Growing mushrooms is meeting challenges while aiming for sustainability and circularity. Wherever the producer is located, commercial strains are the same originating from several producers. Following the harvest, enormous quantities of spent mushroom substrate containing spores are disposed presenting a type of foreign material pressure on the ecosystem in the form of the loss of genetic diversity in wild mushroom populations. This challenge can be mitigated by bioprospecting local strains and using them to generate commercial inoculum. Accordingly, the mycoceutical potential of five polypore mushroom species from Serbia was evaluated: secondary metabolite composition, oxidative damage prevention, anti-tyrosinase, and anti-angiotensin converting enzyme (ACE) properties. The phenolic pattern was comparable in all samples, but the amounts of specific chemicals varied. Hydroxybenzoic acids were the primary components. All samples had varying quantities of ascorbic acid, carotene, and lycopene, and showed a pronounced inhibition of lipid peroxidation (LPx) and ability to scavenge HO•. Extracts were more potent tyrosinase inhibitors but unsuccessful when faced with ACE. Fomitopsis pinicola had the strongest anti-tumor efficacy while Ganoderma lucidum demonstrated strong selectivity in anti-tumor effect in comparison to healthy cells. The evaluated species provided a solid foundation for commercial development while keeping the local ecology in mind.

Virtual Reality (VR) technology in education has the potential to revolutionize the Indian school education system. This research study investigates the present state of VR adoption, perceived benefits, concerns, and future expectations among both students and educators. The survey-based approach collected responses from 45,000 students and 2,000 educators across a diverse range of schools in India. The findings highlight a mixed current landscape with significant room for expansion in VR utilization. Both students and educators express optimism regarding the benefits of VR, recognizing its capacity to enhance engagement, comprehension, and motivation in the learning process. However, challenges, including budget constraints, the need for training and support, and concerns about student safety, must be addressed to effectively integrate VR into education. Expectations for the future emphasize inclusivity, accessibility, and customized learning experiences. The research underscores the transformative potential of VR in Indian education while emphasizing the necessity of addressing practical challenges for its successful implementation.

Hemilauxania parvula sp. nov., a new fossil species of the family Lauxaniidae (Diptera: Acalyptratae), is described and illustrated from Oise amber, France (Eocene, lower Ypresian, ca 53 Ma) and its relationship is discussed. Inasmuch as this first finding of a member of Schizophora in Oise amber probably represents the oldest known record of this group of Diptera, the age of Schizophora, based on the known fossil records, is discussed.

Cybersecurity plays a relevant role in the new digital age in aerospace industry. Predictive algorithms are necessary to interconnect complex systems within the cyberspace. In this context, where security protocols do not apply, challenges to maintain data privacy and security arise for the organizations. Thus, the need of cybersecurity is required. The four main categories to classify threats are interruption, fabrication, modification and interception. They all share a common thing, soften the three pillars which cybersecurity needs to guarantee. These pillars are confidentiality, availability and integrity of data (CIA). Data injection can contribute to this event by creation of false indicators which can lead to errors creation during the manufacturing engineering process. In this paper, the impact of data injection on existing dataset used on manufacturing process is shown. The design model synchronizes the following mechanisms developed within machine learning techniques which are, the risk matrix indicator to assess the probability of producing an error, the dendrogram to clusters the dataset in groups with similarities, the logistic regression to predict the potential outcomes and the confusion matrix to analyze the performance of the algorithm. The results presented in this study, which was carried out using a real dataset related to the electrical harnesses installed in a C295 military aircraft, estimate that injection of false data indicators increase the probability of errors creation in 24.22 % on the predicted outcomes required for the generation of the manufacturing process. Overall, implementing cybersecurity measures and advanced methodologies to detect and prevent cyberattacks are necessary.

Kratom (Mitragyna speciosa Korth. Havil) has been considered a narcotic drug for years, barred by the law in many parts of the world, while extensive research over the past few decades proves its several beneficial effects some of which are still in ambiguity. In many countries, including Thailand, the indiscriminate use and abuse of Kratom have led to the loss of life. Nonetheless, researchers have isolated almost fifty pure compounds from Krat-om, most of which are alkaloids. The most prevalent compounds, mitragynine and 7-hydroxy mitragynine, are reported to display agonist morphine-like effects on human μ-opioid receptors and antagonists at κ- and δ-opioid receptors with multimodal effects at oth-er central receptors. Mitragynine is also credited to be one of the modulatory molecules for the Keap1-Nrf2 pathway and SOD, CAT, GST, and associated gene’s upregulatory cascades leading to play a pivotal role in neuroprotective actions while its long-high dose is evident to cause the neuronal disorder. Additionally, the anti-inflammatory, antioxidative, antibac-terial, and gastroprotective effects are well-cited. In this context, this review focuses on the research gap to resolve the ambiguities about the neuronal effects of kratom to demonstrate its prospects as a therapeutic target for neurodisorders connecting with other pharmacologi-cal effects.

Objective: The current study aimed to delineate the relationship of furin with inflammation while cervical intraepithelial neoplasia progresses to cancer. Study Design:This cross-sectional study included 81 women who required colposcopic examinations. The study groups were formed based on pathological results: Group I included women with cervical intraepithelial neoplasia (CIN) I (n=30); Group II included women with CIN II-III (n=28); and Group III included women with cervical cancer (CC) (n=23). Furin, ki-67, and p16 levels were evaluated based on immunostaining intensity. The inflammatory indices were calculated parallel with the literature from routine blood samples retrieved within one week before the procedure. Results:Furin expression gradually increased from CIN I to CIN II-III and from CIN II-III to CC, respectively (p < .001, p = .005). The NLR, MLR, PLR, and SII were significantly higher in the CC group (p < .001). ROC curve analysis unveiled that NLR, MLR, PLR and SII predicted the presence of CC with a cutoff value of 2.39 for NLR (sensitivity: 91.3%, specificity: 63.8%, AUROC: 0.79, p < .001); a cutoff value of 0.27 for MLR (sensitivity: 78.3%, specificity: 72.4%, AUROC: 0.77, p = .009); a cutoff value of 123 for PLR (sensitivity: 100%, specificity: 41.4%, AUROC: 0.70, p = .04); and a cutoff value of 747 for SII (sensitivity: 69.6%, specificity: 90.7%, AUROC: 0.71, p = .014). Conclusion:Furin expression increased gradually in parallel to the severity of cervical intraepithelial neoplasia. The inflammatory indices were higher in the presence of CC and denoted good discrimination ability for predicting cervical cancer.

The surgical extraction of the impacted third molar is frequently associated with several complications. The purpose of this study is to assess how two different surgical protocols affect post-operative complications during the extraction of the lower third molars. In order to compare and evaluate two different techniques (triangular flap vs envelope flap), and the relative post-extraction complications, two groups of 150 patients each, underwent to surgical third molar extraction and 60 days of follow-up. A complication rate founded in two groups was respectively 14,00% in group A and 17,33% in group B. There was a strong association between smoking (OR:2.8) and the use of oral contraceptives (OR:1.75) with complications. The age and sex-related incidence of complications in hard tissue healing finds great variability in the literature; the analysis performed on our data did not show a statistically significant association between them. Even though related to a higher incidence of transient changes in sensitivity, it was found that the envelope flap saw a lower percentage of complications. There is still no clarity on which is the best protocol for the extraction of the lower third molar, and the choice often depends on the surgeon’s experience.

Background: The interruption of the activity of the population-based organized colorectal cancer (CRC) screening programs due to the COVID pandemic may have affected their results in terms of detection of preneoplastic lesions and CRC. We evaluated the impact of the COVID pandemic on the delays, participation, adherence to colonoscopies, lesions detected, and CRC stage at di-agnosis in a CRC screening program. Methods: We analyzed all the invitations between January 1, 2019, and December 31, 2021. We defined the pandemic period as the period after March 12, 2020. We calculated the delay intervals (successive and all rounds), the rates of participation, adherence to colonoscopy after a positive fecal immunochemical test (FIT), and the diagnostic yield of colonoscopy, specifically CRC and colorectal neoplasia (CRC and/or adenoma), as well as CRC stage at diagnosis. Results: In the period analyzed, 976,187 invitations were sent (61.0% pandemic), 439,687 FIT were returned (62.4% pandemic) and 23,092 colonoscopies were performed (59.1% pandemic). Colon-oscopies were normal in 7,378 subjects (32.4%) and a CRC was detected in 916 subjects (4.0%). In successive rounds, the delay increased significantly seven months during the pandemic period (p<0.001). In all the invitations, the delay from the invitation to the colonoscopy increased sig-nificantly by 8 days (p<0.001). Once adjusted for the confounding variables, participation in the screening program increased significantly (OR=1.1; 95% CI=1.09-1.11), with no changes in the adherence to colonoscopy (OR=0.9; 95% CI=0.8-1.0). We found no differences in the diagnostic yield of colonoscopy in terms of CRC (OR=0.90; 95% CI=0.78-1.02) or colorectal neoplasia (OR=0.98; 95% CI=0.92-1.03) detection. Finally, we found no differences in CRC stage at diagnosis (p=0.2). Conclusions: Although the interruption of the CRC screening program due to the COVID pan-demic increased the delays, it did not reduce participation, adherence to colonoscopy, or the di-agnostic yield of colonoscopy.

Ribosomal proteins (RPs) mediate protein synthesis and stability of the ribosomal complex. RPs and rRNA form ribosomal subunits and ri-bosomes, the cellular machinery for protein synthesis, a fundamental biological process related to cell growth and proliferation. The differ-ences between paralogs within the same RP family have led them to ac-quire extraribosomal functions involved in plants' growth, develop-ment, and biotic and abiotic stresses. From transcriptomic analysis, it has been revealed that ribosomal proteins have a crucial role during MTs development. The RPLs; RPL11, RPL29 and RPL40 interact with PEBP family members (Phosphatidylethanolamine-binding proteins), poten-tial activators in the MTs development. In potatoes, genome editing is a promising technology to introduce crop breeding traits. Recently, the edition of the genome through the CRISPR/Cas9 system has made it the most efficient and powerful genetic modification method. Based on this, the gene modulation by overexpression and silencing in RPL11, RPL29 and RPL40 will guide us to understand the effect on the microtuberiza-tion process and produce improved potato plants with the capability of growing under adverse environments (biotic and abiotic stresses). By understanding the molecular biology mechanisms that RPs govern, we can improve crops under today's changing climatic conditions.

We investigated the influence of the fuel change, from pure hydrogen to hydrogen-ammonia mixture at different percentage, on the electrochemical behaviour of 50 mm in diameter Solid Oxide Fuel Cells (SOFC) with sputtered thin buffer layers of Gd doped Ceria, varying the working temperatures from 800°C to 650°C. The results show that the performances of the cells are not affected by the fuel change for the high working temperatures (800°C and 750°C). As an example, a power density value of 802 mW∙cm-2 at 1 A∙cm-2 is found when directly feeding the cell with 8 Nml∙min-1cm-2 of ammonia and with an equivalent flowrate of 12 Nml∙min-1cm-2 of H2. These power density output values are comparable to those obtained in industrial State of Art (SoA) SOFC cells with screen printed buffer layers fed with higher hydrogen flowrates, thanks to the improved electrochemical performances obtained in the case of cells with sputtered thin buffer layers of Gd doped Ceria. At lower working temperatures (700°C and 650°C), slight changes in the electrochemical behaviour of the cells are observed. Nevertheless, also in this temperature range, we obtain an output current density value of 0.54 A∙cm-2 in pure ammonia flowrate of 12 Nml min-1cm-2, at 800 mV and 700°C, equal to the value observed in SoA button cells with industrial screen printed GDC barrier layer fuelled with 16 Nml∙min-1cm-2 of H2. These results pave the way towards the use of innovative SOFC structures with sputtered thin buffer layers fuelled by ammonia.

Proteasomes critically regulate proteostasis via protein degradation. Proteasomes are multisubunit complexes composed of the 20S proteolytic core particle (20S CP) that, in association with one or two 19S regulatory particles (19S RPs), generate the 26S proteasome. 26S is the major proteasomal complex in the cells. Native gel protocols are used to investigate the 26S/20S ratio. However, a simple method for detecting these proteasome complexes in the cells is missing. To this end, using CRISPR technology, we YFP tagged the endogenous PSMB6 (b1) gene, a 20S CP subunit, and co-tagged endogenous PSMD6 (Rpn7), a 19S RP subunit, with mScarlet fluorescent protein. We observed colocalization of YFP and mScarlet fluorescent proteins in the cells, with higher nuclear accumulation. Nuclear proteasomal granules are formed under osmotic stress, and all were positive for YFP and mScarlet. Previously we have reported that PSMD1 knockdown, one of the 19 RP subunits, gives rise to a high level of “free” 20S CP. Intriguingly, under this condition, the 20S-YFP remained nuclear, whereas the PSMD6-mScarlet is mostly in cytoplasm, demonstrating the distinct subcellular distribution of uncapped 20S CP. Lately, we have shown that the PSMA3 (a7) C-termininus, a 20S CP subunit, binds multiple intrinsically disordered proteins (IDPs). Remarkably, truncation of the PSMA3 C-terminus is phenotypically reminiscent of PSMD1 knockdown. These data suggest the PSMA3 C-terminal region is critical for the 26S proteasome integrity.

Intelligent systems are increasingly present in various areas of society, gaining special relevance in healthcare environments. In this work, grounded on previous developments proposed by the authors, the evolution and improvement of a novel intelligent system focused on the diagnosis of obstructive sleep apnea (OSA) is addressed. To do this, starting from two packages of information of a heterogeneous nature, and deploying a set of Machine Learning classification algorithms, focused each of them on different levels of the apnea-hypopnea index (AHI), as well as a set of cascaded expert systems, it is possible to obtain a series of risk metric pairs (Statistical Risk, Symbolic Risk) for each AHI level, understood as a warning forecast associated with the early detection of the pathology. The risk indicators of each pair are subsequently aggregated by means of a symbolic inference system, whose knowledge base was determined using the automatic rule generation approach proposed by Wang and Mendel. At the output of each inference system, a risk indicator is obtained for each AHI level, the Apnea Risk, whose interpretation makes it possible to discriminate between patients who could suffer OSA and those who do not, as well as to generate the appropriate recommendations. For the initial tests of the system, the design and development of a specific software artifact was carried out using data from 4,400 patients from the Álvaro Cunqueiro Hospital in Vigo, obtaining when applied to the test set AUC values within the range 0.74–0.88, which invites optimism and points to the benefits expected from the architecture of the proposed intelligent system.

The paper investigates experimentally the influence of the Fused Filament Fabrication (FFF) pre-processing strategy on the tribological properties of parts made of PEI (polyetherimide), investigating the difference in the weight loss of the samples caused by abrasive wear before and after the test. The samples were tested for abrasive wear resistance on a tribometer constructed according to ASTM G65/16 (dry sand). Two types of specimen printing orientation along X-axis (lengthwise) and along Z-axis (heightwise) were tested in the study. Three types of path generation strategies were used for manufacturing "X" and "Z" specimens and totally 18 samples were made and tested. Path deposition strategy was carried out with path deposition width of 0.5mm and parallel paths in all slicing layers. In order to reduce the voids in volume, deposition path axes in subsequent layers were shifted by 0.25mm offset. Garnet abrasive Fe3Al2(SiO4)3 was used for this test. The analysis of the experimental data shows the relationship between the samples building direction (X, Z), applied deposition strategies (1X - 3X and 1Z - 3Z) on the resulting resistance to abrasive wear.Keywords: PEI, FFF, path generation strategy, abrasive wear

The problems of operating range and costs are the two most critical bottlenecks restricting the extensive application of electric vehicles at home and abroad. There are also some prominent problems in China's electric vehicles, such as slow improvement of electric vehicle's operating range, difficulty in charging, slow charging, low utilization efficiency of charging resources, and high battery cost for electric vehicles, which lead to poor competitiveness of electric vehicles compared with traditional internal combustion engine (I.C.E.) vehicles. This paper analyzes the key factors restricting the development and popularization of electric vehicles in China from the aspects of strategic policy, sales situation and self problems. Through summarizing the experience and lessons of French standardization development strategy and electric vehicle development mode, this paper puts forward the hypothesis leading the development of electric vehicles through standardization to enhance their competitiveness, gives the specific suggestions, and briefly analyzes the feasibility from the aspects of product situation. The research content of this paper provides a certain basis and ideas for the future research work.

Based on the example of wintering waterbirds in the Baltic Sea, we show a method that is useful in setting priorities for species management. The Value Factor (VF) shows which species in the region are the most valuable and on which ones conservation measures need to focus. Every year 4,400,000 waterbirds winter in the Baltic. Among which the highest priority species are velvet scoter Melanitta fusca (VS, VF=153) and long-tailed duck Clangula hyemalis (LTD, VF=204): 74% and 40%, respectively, of the world populations and over 90% of the EU populations of both species spend the winter there. Management plans (MP) regulating the protection of marine Natura 2000 sites (MPA) and dedicated to the protection of VS and LTD have been implemented in 65% and 51%, respectively, of MPAs in the Baltic. Poland, a key country for the survival of these species, has not implemented a single MP despite the existence of documentation confirming their crucial importance for seaducks, and on the pressures occurring there. We suggest using the VF concept to define priority species. On this basis, it will be possible to identify gaps in the protection of the most seriously threatened species and implement conservation measures in the most appropriate sites

Hydrological modeling for water management in large watersheds requires accurate spatially-distributed rainfall time series. In case of low coverage density of ground-based measurements, satellite precipitation products (SPP) constitute an attractive alternative, the quality of which must nevertheless be verified. The objective of this study was to evaluate, at different time scales, the reliability of six SPPs against a 2-year record from a network of 14 rainfall gauges located in the Ankavia catchment (Madagascar). The SPPs considered in this study are the African Rainfall Estimate Climatology (ARC2), the Climate Hazards group Infrared Precipitation with Station data (CHIRPS), the ECMWF Reanalysis (ERA5), the Integrated Multi-satellitE Retrievals for Global Precipitation Measurement (IMERG), the Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks (PERSIANN), and the African Rainfall Estimation (REF2) products. The results suggest that IMERG (R² = 0.63, slope of linear regression a = 0.96, root mean square error RMSE = 12 mm/day, mean absolute error MAE = 5.5 mm/day) outperforms other SPPs at the daily scale, followed by REF2 (R² = 0.41, a = 0.94, RMSE = 15 mm/day, MAE = 6 mm/day) and ARC2 (R² = 0.30, a = 0.88, RMSE = 16 mm/day, MAE = 6.7 mm/day). All SPPs, with the exception of the ERA5, overestimate the ‘no rain’ class (0 – 0.2 mm/day). ARC2, IMERG, PERSIANN, and REF2 all underestimate rainfall occurrence in the 0.2 – 150 mm/day rainfall range, whilst CHIRPS and ERA5 overestimate it. Only CHIRPS and PERSIANN could estimate extreme rainfall (>150 mm/day) satisfactorily. According to the Critical Success Index (CSI) categorical statistical measure, IMERG performs quite well in detecting rain events in the range 2-150 mm/day, whereas PERSIANN outperforms IMERG for rain events larger than 150 mm/day. Because it performs best at daily scale, only IMERG was evaluated for time scales other than daily. At the yearly and monthly time scales, the performance is good with R² = 0.97 and 0.87, respectively. At the event time scale, the probability distribution function PDF of rain gauge values and IMERG data show good agreement. However, at hourly time scale, the correlation between ground-based measurements and IMERG data becomes poor (R² = 0.20). Overall, the IMERG product can be regarded as the most reliable satellite precipitation source at monthly, daily and event time scales for hydrological applications in the study area, but the poor agreement at hourly time scale and the inability to detect extreme rainfall >200 mm/day may nevertheless restrict its use.

The IgM and IgT classes were previously identified and characterized in the Antarctic teleost Trematomus bernacchii, a species belonging to the Perciform suborder Notothenoidei. Herein we characterized the gene encoding the polymeric immunoglobulin receptor (pIgR) in the same species and compared it to pIgR of multiple teleost species belonging to five perciform sub-orders, including 11 Antarctic and one non-Antarctic (Cottoperca gobio) notothenioid species, the latter living in less cold periantarctic sea. Antarctic pIgR genes displayed particularly long in-trons marked by sites of transposable elements and transcription factors. Furthermore, analysis of T. bernacchii pIgR cDNA unveiled multiple amino acid substitutions unique to Antarctic species, all introducing adaptive features, including N-glycosylation sequons. Interestingly, C. gobio shared most features with the other perciforms rather than with the cold adapted relatives. T. bernacchii pIgR transcripts were predominantly expressed in mucosal tissues, as indicated by q-PCR and in situ hybridization analysis. These results suggest that in cold adapted species pIgR preserved its fundamental role in mucosal immune defense, although remarkable gene structure modifications occurred.

A realistic approach for gathering high-resolution observation of the rainfall rate, R, in the vertical plane is to use data from vertical pointing Doppler radars. After accounting for the vertical air velocity and attenuation, it is possible to determine the fine, spatially resolved drop size spectra and to calculate R for further statistical analyses. The first such results in a vertical plane are reported here. Specifically, we present results using MRR-Pro Doppler radar observations at resolutions of ten meters in height over the lowest 1.28 km as well as ten seconds in time over four sets of observations using two different radars at different locations. Both correlation functions and power spectra are useful for translating observations and numerical model outputs of R from on one scale down to other scales that may be more appropriate to particular applications such as flood warnings and soil erosion, for example. However, it was found in all cases that while locally applicable radial power spectra could be calculated, because of statistical heterogeneity, most of the power spectra lost all generality and proper correlation functions could not be computed in general except for one 17 minute interval. Nevertheless, these results are still useful since they could be combined to develop catalogs of power spectra over different meteorological conditions and in different climatological settings and locations. Furthermore, even within the limitations of these data, this approach is being used to gain a deeper understanding of rainfall to be reported in a forthcoming paper.

The relaxation process of lithium batteries caused by load variation is considered. It is shown that such processes have strong dependence on internal physical and chemical processes and battery technical conditions. Theoretical expressions of the relaxation process caused by a step-like load variation have been obtained for 1^st and 2^nd order equivalent electrical circuits. The experimental investigations show that the obtained models fit the real relaxation processes and the behavior of the identified parameters could be explained by specific features of physical and chemical processes within the lithium battery. It should be noted that the obtained results can be generalized for a different type of electrochemical power source. The proposed approach makes it possible to provide means for electrochemical power source characterization and diagnostic, the main advantages of which are good time localization of measurement procedures and inexpensive apparatus implementation.