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Preprint ARTICLE | doi:10.20944/preprints202211.0292.v1

Identification of Polymorphism Angiotensin Ii Type 1 Receptor (AT1) 1166 A/C Gene and Potassium Levels in Pre-Eclampsia among The Madurese Population

Zakkiyatus Zainiyah, Eny Susanti, Novita Wulandari

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: Preeclampsi; AT1; Pottasium; preeclampsi; Madurese

Online: 16 November 2022 (01:47:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints201909.0038.v3

Application of Local Gauge Theories to Fluid Mechanics Part 1 - Fluid Mechanics as a Local Gauge Theory and Relation to Navier-Stokes Equations

Thomas Merz

Subject: Physical Sciences, Condensed Matter Physics Keywords: fluid dynamics; turbulent flow; stationary flow; SO(3) local gauge; quasiparticle; non-linearity

Online: 12 October 2022 (12:23:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0334.v1

Computational Biology and Machine Learning Approaches to Identify the Rubber Tree (Hevea brasiliensis L.) Genome Encoded Potential MicroRNAs Targeting Rubber Tree Virus 1

Muhammad Aleem Ashraf, Hafiza Kashaf Tariq, Jallat Khan, Han Cheng

Subject: Biology And Life Sciences, Plant Sciences Keywords: Rubber tree capillovirus 1; microRNAs; plant-virus interaction; RNAi: computational algorithms; gene silencing, minimum free energy

Online: 22 July 2022 (09:52:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0156.v1

Dynamics of Serum Thymidine Kinase 1 at the First Cycle of Neoadjuvant Chemotherapy Predicts Outcome of Disease in Estrogen-receptor-positive Breast Cancer

Bernhard Tribukait

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: circulating thymidine kinase 1; cell loss; biomarker; early treatment response; breast cancer

Online: 8 September 2021 (16:25:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0311.v1

Genome-Wide Identification and Expression Analysis of Sucrose Nonfermenting-1-Related Protein Kinase (SnRK) Genes in Triticum aestivum in Response to Abiotic Stress

Shefali Mishra, Pradeep Sharma, Rajender Singh, ratan Tiwari, Gyanendra Pratap Singh

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Genome-wide; SnRK and abiotic stress.; wheat

Online: 13 July 2021 (15:11:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0489.v1

Monitoring Watering Practices on European Rice Paddy Fields with Sentinel-1: Characterizing European Rice in Multitemporal SAR Sequences for Mapping and Traceability Purposes

David Marzi, Fabio Dell'Acqua

Subject: Engineering, Automotive Engineering Keywords: Agriculture; Copernicus initiative; Farming; Food traceability; Organic Farming; Rice; Rice paddy fields; Water Management; Sentinels

Online: 20 May 2021 (12:32:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0060.v1

A Polyphenol Rich Extract from Solanum melongena L. DR2 Peel Exhibits Antioxidant Properties and Anti-Herpes Simplex virus Type 1 Activity In Vitro

Antonella Di Sotto, Silvia Di Giacomo, Donatella Amatore, Marcello Locatelli, Annabella Vitalone, Chiara Toniolo, Giuseppe Leonardo Rotino, Roberto Lo Scalzo, Anna Teresa Palamara, Maria Elena Marcocci, Lucia Nencioni

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: eggplant peel; polyphenols; HSV-1; Warburg effect; antioxidant activity; antiviral agents; vegetable waste

Online: 3 August 2018 (04:53:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0248.v1

Ahmed Glaucoma Valve Implantation: Graft-Free Short Tunnel Small Flap versus Scleral Patch Graft After 1 Year Follow-Up: A Randomised Clinical Trial

Mohammad Pakravan, Mohammadmehdi Hatami, Hamed Esfandiari, Shahin Yazdani, Azadeh Doozandeh, Bahareh Kheiri, Ian Conner

Subject: Medicine And Pharmacology, Ophthalmology Keywords: short tunnel small flap; glaucoma drainage device implantation; tube exposure; STSF; Ahmed glaucoma valve; AGV

Online: 15 June 2018 (09:40:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0180.v1

Low Levels of IgG Recognizing the Alpha-1-Antitrypsin (A1AT) ^50-63 Peptide and Its Association with Taiwanese Women with Primary Sjögren's Syndrome

Yu-Sheng Chang, Chih-Hong Pan, Che-Chang Chang, Kai-Leun Tsai, Han-Wen Chou, Jin-Hua Chen, Sheng-Hong Lin, Yi-Ying Lu, Chih-Chun Tai, Yi-Fang Lin, Ching-Yu Lin

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: primary Sjögren's syndrome; alpha-1-antitrypsin; inhibitor; 4-hydroxy-2-nonenal; autoantibody isotypes; serum

Online: 30 October 2017 (04:30:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints201709.0171.v1

Investigation of Geological Structures of Hydrogeological Importance of 1:100,000 Sheet 185 (Paiko) North-Central Nigeria Using Integrated Geophysical and Remote Sensing Techniques

Jude Steven Ejepu, Peter Olasehinde, Appollonia A. Okhimamhe, Ipoola Okunlola

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: groundwater; hydrogeological structures; remote sensing; aeromagnetic survey; radial vertical electrical sounding

Online: 30 September 2017 (12:29:44 CEST)

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Aeromagnetic data coupled with Landsat ETM+ data and SRTM DEM have been processed in order to map regional hydrogeological structures in the basement complex region of Paiko, north-central Nigeria. Lineaments were extracted from derivative maps from aeromagnetic, Landsat ETM+ and SRTM DEM datasets. Ground geophysical investigation utilizing Radial Vertical Electrical Sounding (RVES) was established in nine transects comprising of four sounding stations which are oriented in three azimuths. Source Parameter Imaging (SPI) was employed to map the average depths structures from aeromagnetic dataset. Selected thematic layers which included lineaments density, lithologic, slope, drainage density and geomorphologic maps were integrated and modelled using ArcGIS to generate groundwater potential map of the area. Groundwater zones were classified into four categories: very good, good, moderate and poor according to their potential to yield sustainable water to drilled wells. Results from RVES survey reveal a close correlation to lineaments delineated from surface structural mapping and remotely sensed datasets. Hydrogeological significance of these orientations suggest that aeromagnetic data can be used to map relatively deep-seated fractures which are likely to be open groundwater conduits while remotely sensed lineaments and orientations delineated from the RVES survey may indicate areas of recharge. Regions with high lineament density have relatively better groundwater potential. This is attributable to areas having deep weathering profiles associated with intrusive bodies that have resulted in intense fracturing in the area. Drill depths in this area should target a minimum of 80 m to ensure sufficient and sustainable supplies to drilled wells. The outcome of this study should act as information framework that would guide the siting of productive water wells and while providing needed information for relevant agencies in need of data for the development of groundwater resources.

Preprint ARTICLE | doi:10.20944/preprints202404.1212.v1

A Pig as a Model to Test Cardiovascular Devices

Yanina L. Rusakova, Denis S Grankin, Kseniya S. Yu. Podolskaya, Irina Yu. Jhuravleva

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: laboratory mini-pigs; transesophageal echocardiography; angiography; aortic morphometry

Online: 18 April 2024 (10:43:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1263.v1

Effects of Tb³⁺ on Properties of Luminescent Calcium Sulfate Cement

Dinara R. Khayrutdinova, Margarita A. Goldberg, Alexander S. Fomin, Elizaveta D. Nosova, Polina A. Krokhicheva, Sergey V. Smirnov, Alexei A. Egorov, Anatoliy A. Konovalov, Alexander I. Ogarkov, Tatiana O. Obolkina, Sergey M. Barinov, Vladimir S. Komlev

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: calcium sulfate; bone cement; terbium; solubility; calcium phosphate layer

Online: 19 October 2023 (12:38:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0400.v1

Estimation of ALU Repetitive Element in Plasma as a Cost-Effective Liquid Biopsy Tool for Disease Prognosis in Breast Cancer

Madhumathy G Nair, Rakesh S Ramesh, Chandrakala M, Apoorva D, Snijesh VP, Vishakha Ramamurthy, Vidya M Somashekaraiah, Anupama CE, Kiruthiga Raghunathan, Anuradha Panigrahi, Manjula Das, Sujan K. Dhar, Jyothi S Prabhu

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Breast Cancer; Liquid biopsy; ctDNA; ALU 247; Disease progression; Prognosis

Online: 21 December 2022 (11:43:52 CET)

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Background: Liquid biopsy is widely recognised as an efficient diagnostic method in oncology for disease detection and monitoring. Though examination of circulating tumor cell (CTC) is mostly implemented for assessment of genomic aberrations, need of complex methodologies for their detection has impeded its acceptance in low resource settings. We evaluated the cell free DNA (cfDNA) as a liquid biopsy tool and investigated its utility in breast cancer patients. Methods: Total cell free DNA was extracted from plasma of breast cancer patients (n=167) with median follow up of more than 5 years, at various stages of the disease. Quantitative PCR was performed to estimate the copy numbers of two fractions of ALU repetitive elements (ALU 115 and ALU 247) and DNA Integrity (DI) was calculated as the ratio of ALU 247/115. Mutations in TP53 and PIK3CA in the cfDNA was estimated by next-gen sequencing (NGS) in a subset of samples. Association of the levels of both the ALU fragments with various clinico-pathological factors and disease-free survival at various stages were examined. Nomogram models were constructed with clinical variables and ALU 247 levels to predict disease-free survival and best performing model was evaluated by decision curve analysis. Results: DI and ALU 247 levels were significantly lower (p<0.0001) in the post-operative plasma when compared to their pre-surgery levels. DI and ALU 247 were found to be significantly higher in patients with metastasis (p<0.05). Patients with higher levels of ALU 247 in their post-operative plasma had significantly poor disease-free survival (p=0.005). Higher level of ALU 247 in circulation also correlated with low tumor-infiltrating lymphocytes (TIL) within their primary tumors in the ER-negative breast cancer subtype (p=0.01). Cox proportional hazard analysis confirmed ALU 247 as an independent variable of disease-free survival both in univariate and multivariate analysis [HR 1.3 (95% CI 1.047 to 1.613, p= 0.017)]. Nomogram model showed addition of ALU 247 with other variables significantly improved (C-index-0.823) the predictive ability of the model. Conclusion: Our results confirm the utility of cfDNA as an evolving liquid biopsy tool for molecular analysis. Evaluation of larger fragment of cfDNA estimated through ALU 247 can provide vital information concurrent with the pathological process of disease evolution in breast cancer and warrants expansion to other cancer types.

Preprint ARTICLE | doi:10.20944/preprints202404.0707.v1

Agroforestry: A Sustainable Land-Use Practice for Enhancing Productivity and Carbon Sequestration in Madhupur Sal Forest, Bangladesh

Mst. Sohela Afroz, S. M. Kamran Ashraf, Md. Tanbheer Rana, Saleha Khatun Ripta, Sumaiya Binte Rahman Asha, S. M. Sanjida Tasnim Urmi, HYAKUMURA KIMIHIKO, Kazi Kamrul Islam

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Agroforestry, Carbon Sequestration, Productivity, Madhupur Sal Forest, Sustainable land-use practice

Online: 10 April 2024 (10:28:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0202.v1

Integrating High-Resolution Mass Spectral Data, Bioassays and Computational Models to Annotate Bioactives in Botanical Extracts: Case Study – Analysis of Centella asiatica Extract Associates Di-Caffeoylquinic Acids with Protection against Amyloid-β Toxicity in an MC65 cell model

Armando Alcazar-Magana, Ashish Vaswani, Kevin S. Brown, Yuan Jiang, Md Nure Alam, Maya Caruso, Parnian Lak, Paul Cheong, Nora E. Gray, Joseph F. Quinn, Amala Soumyanath, Jan F. Stevens, Claudia S. Maier

Subject: Biology And Life Sciences, Life Sciences Keywords: Centella asiatica; bioactives; bioassays; computational methods; Elastic Net; spectral networks; GNPS

Online: 3 January 2024 (09:30:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1031.v1

Genomic and Transcriptomic Analysis of Pea (Pisum sativum L.) Breeding Line ‘Triumph’ with High Symbiotic Responsivity

Evgeny A. Zorin, Anton S. Sulima, Aleksandr I. Zhernakov, Daria O. Kuzmina, Valeria A. Rakova, Marina S. Kliukova, Daria A. Romanyuk, Olga A. Kulaeva, Gulnara A. Akhtemova, Oksana Y. Shtark, Igor A. Tikhonovich, Vladimir A. Zhukov

Subject: Biology And Life Sciences, Plant Sciences Keywords: plant-microbe symbiosis; legumes; Pisum sativum; symbiotic responsivity; genomics; transcriptomics; differential gene expression; molecular breeding

Online: 15 November 2023 (15:49:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0160.v1

Review and Meta-Analysis of the Evidence for Choosing Between Specific Pyrethroids for Programmatic Purposes.

Natalie Lissenden, Mara Kont, John Essandoh, Hanafy M Ismail, Thomas S Churcher, Ben Lambert, Audrey Lenhart, Philip J McCall, Catherine L Moyes, Mark J I Paine, Giorgio Praulins, David Weetman, Rosemary S Lees

Subject: Biology And Life Sciences, Insect Science Keywords: Pyrethroid; pyrethroid resistance; insecticide resistance; insecticide resistance management; vector control; malaria; malaria control; mosquito; Anopheles

Online: 6 August 2021 (11:19:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201708.0064.v1

Soluble CD40 Iigand and Oxidative Response Are Reciprocally Stimulated during Shiga Toxin-Associated Hemolytic Uremic Syndrome

Maria J Abrey Recalde, Romina S. Alvarez, Fabiana Alberto, Maria p Mejias, Maria V. Ramos, Romina J. Fernandez Brando, Andrea C. Bruballa, Ramon A. Exeni, Laura Alconcher, Cristina A. Ibarra, María M. Amaral, Marina S. Palermo

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: hemolytic uremic syndrome; oxidative stress; blood platelets; shiga toxin 2; CD40L

Online: 18 August 2017 (11:46:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0380.v1

Obesogens in Adolescence. Challenging Aspects and Prevention Strategies.

Marina Nicolaou, Meropi Toumba, Alexandros Kythreotis, Habib Daher, Nicos Skordis

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: endocrine disrupting chemicals; obesogens; obesity; children; adolescents; prevention strategies

Online: 5 April 2024 (06:51:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0836.v1

Precision Medicine Approaches in Acute Myeloid Leukemia with Adverse Genetics

Nicole Santoro, Prassede Salutari, Mauro Di Ianni, Andrea Marra

Subject: Medicine And Pharmacology, Hematology Keywords: acute myeloid leukemi; adverse genetics; leukemogenesis; targeted therapy; immunotherapy

Online: 14 March 2024 (10:08:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0282.v1

A Novel Methodological Approach to Simulating the Growth of Photosynthetic Organisms Using Long-Term Meteorological Sequences: A Case Study of a Microalgae (Chlorella vulgaris)

Ousmane Wane, Luis F. Zarzalejo, Francisco Ferrera-Cobos, Ana A. Navarro, Rita X. Valenzuela

Subject: Engineering, Other Keywords: Long-term meteorological sequences; Simulation; Photosynthetic organisms; Wastewater treatment; High-rate algae pond

Online: 3 September 2024 (16:55:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1209.v1

Mitigating Effect of the Sea on Temperatures along Mediterra-Nean Coastal Areas: The Case of the Vine Territory of the Matera DOP – Basilicata (Italy)

Pasquale Cirigliano, Stanislao Esposito, Edmondo Di Giuseppe, Andrea Cresti

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Climate change; Viticulture; Italy-Basilicata region; Bioclimatic indices; Altitude; Temperature; Mediterranean sea

Online: 16 September 2024 (12:21:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1465.v1

Biogas Production from Anaerobic Co-digestion of Cow Manure, Residual Edible Oil with Two Qualities of Waste Activated Sludge

Jesus Eduardo de la Cruz Azuara, Alejandro Ruiz-Marin, Yunuén Canedo-López, Claudia Alejandra Aguilar-Ucán, Rosa María Cerón-Bretón, Julia Griselda Ceron-Breton, Francisco Anguebes-Franseschi

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Biogas; method two-stage; waste activated sludge; sludge calidad; co-substrata

Online: 23 May 2024 (02:56:00 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202404.0620.v1

Effect of Dynamic Neuromuscular Stabilization and Rehabilitation Strategies in Six Year Child with Duchenne Muscular Dystrophy: A Case Study

Neha Chitlange, Sharath Hullumani V, Anam Sasun, Raghuveer Raghumahanti

Subject: Biology And Life Sciences, Other Keywords: Duchenne muscular dystrophy; Balance; Gower’ s sign; Rehabilitation; Physiotherapy; Dynamic neuromuscular stabilization

Online: 9 April 2024 (08:53:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0138.v2

A Computational Method Involving Surface Area to Volume Ratio to Estimate Inorganic Nanoparticle Efficacy

Wesley A. Williams, Ashley J. Denslow, Peter W. Radulovic, Daniel J. Denmark, Shyam S. Mohapatra

Subject: Chemistry And Materials Science, Nanotechnology Keywords: inorganic nanoparticles; in silico; optimization; theranostic; therapeutic; diagnostic; computation; coding; Python

Online: 7 September 2021 (11:57:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1928.v2

Understanding Super Heavy Stable Mass Numbers and Maximum Binding Energy of Any Mass Number with Revised Strong and Electroweak Mass Formula

U.V.S. Seshavatharam, S. Lakshminarayana

Subject: Physical Sciences, Nuclear And High Energy Physics Keywords: ; semi empirical mass formula (SEMF); strong and electroweak mass formula (SEWMF); free nucleons; light house like stable mass number; super heavy mass numbers; revised electroweak term; maximum binding energy of any mass number; avogadro number; unified atomic mass unit ;

Online: 5 August 2024 (07:09:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0081.v1

Research Progress on Spike-Dependent SARS CoV-2 Fusion Inhibitors and Small Molecules Targeting the S2 Subunit of Spike

Matthew R. Freidel, Roger S. Armen

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Arbidol; Toremifene; Entry Inhibitor; Fusion Inhibitor; Spike-dependent; SARS CoV-2; S2 segment; S2 subunit; Surface Plasmon Resonance; Molecular Docking

Online: 4 March 2024 (09:35:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1500.v1

Enhancement of Classifier Performance with Adam and RanAdam Hyper Parameter Tuning for Lung Cancer detection from Microarray Data - In Pursuit of Precision

Karthika M S, Harikumar Rajaguru, Ajin R Nair

Subject: Engineering, Bioengineering Keywords: Lung cancer detection; MAGE data; DimRe; Cancer classification; Adam and RanAdam tuning; FFT; Mixture Model

Online: 26 February 2024 (18:30:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0468.v1

Understanding Atomic Mass Unit, Avogadro Number, Atomic Radii and Electrochemical Equivalents with 4G Model of Final Unification

U.V.S Seshavatharam, S. Lakshminarayana

Subject: Physical Sciences, Theoretical Physics Keywords: 4G model of final unification; nuclear binding energy; electrolysis; electrochemical equivalents; Faraday constant; Faraday Mass; Avogadro number; Newtonian gravitational constant; Weak coupling angle;

Online: 8 February 2024 (07:34:47 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0019.v1

Telomere Regulation by Metabolism Reprogramming

Maria P. Rubtsova, Denis A Nikishin, Maria S Koriagina, Andrey V Vasiliev, Olga A Dontsova

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: telomere; development; ALT; telomerase; metabolism; glycolysis; OXPHOS

Online: 3 January 2024 (03:54:51 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.1272.v1

Mast Cells in Cardiac Remodeling: Focus on the Right Ventricle

Argen Mamazhakypov, Abdirashit Maripov, Akpay S. Sarybaev, Ralph Theo Schermuly, Akylbek Sydykov

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: mast cells; right ventricle; cardiac remodeling

Online: 18 December 2023 (13:17:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1189.v1

Morphometric Analysis of Kasura River Watershed Using RS and GIS Techniques

Vipul S. Chaudhari, Subhash D. Vikhe, Gopal U. Shinde, Harish W. Awari, Vishal K. Ingle

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: Remote Sensing; GIS; Morphometric Analysis; Kasura River Watershed; Digital Elevation Model

Online: 18 December 2023 (02:07:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1006.v1

The Changes of Multiscale Solar Wind Fluctuations at the Path from the Sun to the Earth

Igor D. Volodin, Maria O. Riazantseva, Liudmila S. Rakhmanova, Alexander A. Khokhlachev, Yuri I. Yermolaev

Subject: Physical Sciences, Space Science Keywords: Solar wind; interplanetary magnetic field; intermittency; multispacecraft observations

Online: 14 December 2023 (04:30:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0111.v1

New Polymorph of β-Cyclodextrin with a Higher Bioavailability

Askar K. Gatiatulin, Ilya S. Balakhontsev, Sofia M. Talashmanova, Marat A. Ziganshin, Valery V. Gorbatchuk

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: beta-cyclodextrin; polymorphism; bioavailability; polymorphic transition; dissolution rate

Online: 4 December 2023 (03:05:33 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0014.v1

Breast Cancer in the Tissue of the Contralateral Breast Reduction

Zoë M.A. Kuijlaars, Nadine S Hillberg, Loes Kooreman, Carmen A.H. Severens–Rijvers, Shan Shan Qiu

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: breast cancer; breast reduction; contralateral breast cancer

Online: 1 December 2023 (03:13:14 CET)

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Preprint DATA DESCRIPTOR | doi:10.20944/preprints202311.1377.v1

Draft Genome Sequence of the Commercial Strain Rhizobium leguminosarum bv. viciae RCAM1022

Olga A. Kulaeva, Evgeny A. Zorin, Anton S. Sulima, Gulnara A. Akhtemova, Vladimir A. Zhukov

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Rhizobium leguminosarum; genome sequencing; nitrogen fixation

Online: 22 November 2023 (14:45:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0758.v1

Evaluating the Electromagnetic Shielding of Continuous Carbon Fiber Parts Produced by Additive Manufacturing

Luís C. Martins, Cátia S. Silva, Leandro C. Fernandes, Álvaro M. Sampaio, António J. Pontes

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: additive manufacturing; material extrusion; continuous fiber reinforcement; electromagnetic shielding effectiveness; thermoplastic composite; continuous carbon fiber; multi-material

Online: 12 October 2023 (04:06:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1104.v1

Egg Morphology and Chorionic Ultrastructure of Spotted Lanternfly, Lycorma delicatula (White) (Hemiptera: Pentatomidae)

Jonathan M. Powell, Laura J. Nixon, Austin P. Lourie, Tracy C. Leskey, Spencer S. Walse

Subject: Biology And Life Sciences, Insect Science Keywords: spotted lanternfly; chorion; egg respiration; aeropyles

Online: 18 September 2023 (02:56:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0321.v1

Adsorption of Pb2+ by Activated Carbon Produced by Microwave Assisted K2CO3 Activation of Leaf Sheath Fibre of Date Palm

Khaled D. Alotaibi, Bassim H. Hameed, Hattan A. Alharbi, Saud S. Aloud, John P. Giesy

Subject: Environmental And Earth Sciences, Environmental Science Keywords: activated carbon; metal ions; Phoenix dactylifera L.; isotherm; kinetic; microwave irradiation; biochar

Online: 6 September 2023 (05:06:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.0440.v1

Advance in Microfluidics Techniques for Rapid Detection of Pesticide Residues in Food

Zhuoao Jiang, Yu Zhuang, Shentian Guo, A S M Muhtasim Fuad Sohan, Binfeng Yin

Subject: Engineering, Bioengineering Keywords: pesticide residues; microfluidic; rapid detection; food samples

Online: 7 July 2023 (04:57:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.1095.v1

Chemoinformatics Advances from Egypt: A Review Article

Mohamed A. Raslan, Sara A. Raslan, Eslam M. Shehata, Amr S. Mahmoud, Nagwa A. Sabri

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Chemoinformatics; Bioinformatics; Tetracycline; Formulation

Online: 28 April 2023 (03:32:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0704.v1

The Role of Cardiac Biomarkers in the Diagnosis of Hypertensive Emergency

Mohammed Abdullahi Talle, Anton F Doubell, Pieter-Paul S Robbertse, Sa'ad Lahri, Philip G Herbst

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Hypertensive emergency; diagnosis; lactate dehydrogenase; high sensitivity cardiac troponin T; brain natriuretic peptide; area under the curve

Online: 21 April 2023 (09:35:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202301.0391.v2

A Mini-Review of Current Activities and Future Trends in Agrivoltaics

Alexander V. Klokov, Egor Yu. Loktionov, Yuri V. Loktionov, Vladimir Anatolevich Panchenko, Elizaveta S. Sharaborova

Subject: Engineering, Energy And Fuel Technology Keywords: agrivoltaics; photovoltaics; biogas; renewable energy; agriculture; livestock; horticulture; aquaculture

Online: 16 March 2023 (04:13:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202303.0121.v1

Acetaminophen-trace Pharmaceutical Bioremediation using Two Isolated Novel Environment-Friendly Phenotypically/Genotypically-characterized Streptomyces Strains; Chemo-informatics & Experimentally tested for Cytotoxicity & Biological Activity

Donia H Embarez, Ahmed S. Abdel-Razek, Emad B. Basalious, Magdy Mahmoud, Nadia M Hamdy

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: bioremediation; bio-degradation; trace pharmaceuticals; acetaminophen/paracetamol; toxicity; biological anti-microbial activity; in silico; cheminformatics

Online: 7 March 2023 (02:35:38 CET)

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Preprint REVIEW | doi:10.20944/preprints202303.0018.v1

Corneal Biomechanics and Glaucoma

Rodrigo Brazuna, Ruiz S. Alonso, Marcella Q. Salomao, Bruno F. Fernandes, And Renato Ambrosio Jr.

Subject: Medicine And Pharmacology, Ophthalmology Keywords: Glaucoma; Hysteresis; Biomechanics; ORA; Corvis

Online: 1 March 2023 (10:20:08 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202211.0246.v1

Hydrogen Evolution Volcano(es) – From Acidic to Neutral and Alkaline Solutions

Goitom K. Gebremariam, Aleksandar Z. Jovanović, Ana S Dobrota, Natalia V. Skorodumova, Igor A. Pašti

Subject: Chemistry And Materials Science, Electrochemistry Keywords: hydrogen evolution reaction; catalytic trends; acidic media; neutral media; alkaline media

Online: 14 November 2022 (09:20:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202207.0203.v1

Optimization of Lignin-Nanofiber-Filled Thermoplastic Starch Composite Film Production for Potential Application in Food Packaging

Tawakaltu AbdulRasheed-Adeleke, Evans Chidi Egwim, Ayo Samuel Afolabi, Emmanuel Rotimi Sadiku, Stephen S Ochigbo

Subject: Chemistry And Materials Science, Biomaterials Keywords: lignin; nanocomposite; nanofiber; optimization; percent elongation; starch; tensile strength; Young’s modulus

Online: 14 July 2022 (03:50:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0096.v1

Particle-based Imaging Tools Revealing Water Flows in Maize Nodal Vascular Plexus

Ulyana S. Zubairova, Aleksandra Yu. Kravtsova, Aleksandr V. Romashchenko, Anastasiia A. Pushkareva, Alexey V. Doroshkov

Subject: Biology And Life Sciences, Plant Sciences Keywords: plant 3D imaging; Zea mays L.; vascular system; internodes; nodal plexus; contrast-enhanced magnetic resonance imaging; laser scanning microscopy; lab-on-a-chip; particle image velocimetry; systems biology

Online: 9 May 2022 (03:22:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0205.v1

Strong Viscosity Increase in Aqueous Solutions of Cationic C22-Tailed Surfactant Wormlike Micelles

Vyacheslav S. Molchanov, Andrei V. Rostovtsev, Kamilla B. Shishkhanova, Alexander I. Kuklin, Olga E. Philippova

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: rheology; wormlike micelles; viscosity; EHAC; contour length; SANS

Online: 13 December 2021 (13:23:52 CET)

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Working Paper ARTICLE

Optimal Power Flow Considering Intermittent Solar and Wind Generation using Multi-Operator Differential Evolution Algorithm

Md Alamgir Hossain, Karam M. Sallam, Seham S. Elsayed, Ripon K. Chakrabortty, Michael J. Ryan

Subject: Engineering, Automotive Engineering Keywords: Evolutionary Algorithms; differential evolution; constraints handling techniques; optimal power flow; renewable energy

Online: 10 May 2021 (10:22:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0092.v1

Relationship between Fish Length and Otolith Morphological Characteristics of Sargocentron spiniferum (Forsskål, 1775) from the Southern Red Sea

Yassein A. A. Osman, Kélig Mahé, Samia M. El-Mahdy, Ashraf S. Mohammad, Sahar Mehanna

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Fish size; otolith shape; head side; Sargocentron spiniferum; Red Sea; Egypt

Online: 5 April 2021 (10:26:13 CEST)

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Working Paper ARTICLE

Assessment of Genetic Diversity of Dioscorea praehensilis (Berth.) Collected from Central Region, Ghana Using Simple Sequence Repeat (SSR) Markers

Adeyinka S. Adewumi, Kingsley J. Taah, Paul A. Asare, Michael O. Adu, Paterne A. Agre

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: genetic diversity; Dioscorea praehensilis; SSR markers; Ghana

Online: 8 March 2020 (14:55:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0323.v1

Self-Reported Omega-3 Supplement Use Moderates the Association between Age and Exercising Cerebral Blood Flow Velocity in Older Adults

Carolyn S. Kaufman, Eric D. Vidoni, Jeffrey M. Burns, Mohammed R. Alwatban, Sandra A. Billinger

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: vascular; omega-3; exercise; cerebral blood flow; middle cerebral artery; supplements

Online: 23 February 2020 (13:05:55 CET)

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Working Paper REVIEW

Use of Smartphones for Ensuring Vulnerable Road User Safety through Path Prediction and Early Warning: An In-Depth Review of Capabilities, Limitations and Their Applications in Cooperative Intelligent Transport Systems

Ioannis Vourgidis, Leandros Maglaras, Ahmed S. Alfakeeh, Ali H. Al-Bayatti, Mohamed Amine Ferrag

Subject: Engineering, Control And Systems Engineering Keywords: Cooperative Intelligent Transport Systems (CITS); Vehicle to Pedestrian (V2P); Vulnerable 15 Road Users (VRU); GPS; smartphones; Inertial Measurement Units sensors

Online: 6 February 2020 (03:44:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0107.v1

Reconstructing f(T) Modiﬁed Gravity from ECHDE and ECNADE Models

A. E. Godonou, Ines G. Salako, M. J. S. Houndjo, Etienne Baffou, Joel Tossa

Subject: Physical Sciences, Thermodynamics Keywords: teleparallel gravity; ECHDE; ECNADE

Online: 8 December 2019 (17:54:44 CET)

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Preprint REVIEW | doi:10.20944/preprints201911.0118.v1

Species Delimitation in Sea Anemones (Anthozoa: Actiniaria): From Traditional Taxonomy to Integrative Approaches

Carlos A. Spano, Cristian B. Canales-Aguirre, Selim S. Musleh, Vreni Häussermann, Daniel Gomez-Uchida

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Cnidaria; Hexacorallia; systematics; taxonomy; evolution

Online: 10 November 2019 (16:39:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints201905.0113.v1

Introducing DNA Sequencing to the Next Generation on a Research Vessel Sailing the Bering Sea Through a Storm

Anne-Lise Ducluzeau, Rachel M. Lekanoff, Noah S. Khalsa, Hillary H. Smith, Devin M. Drown

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: education; genomics; nanopore; oceanography; fieldwork

Online: 9 May 2019 (12:57:09 CEST)

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Experiential learning in the field is an opportunity for students to enter the heart of a scientific discipline. Through such experience, they can extract conceptual clues and discover motivational stepping stones that will potentially influence the rest of their education and career choice. Unfortunately, in Biology, the inescapable topic of Next-Generation Sequencing represents a challenge when it comes to create an educational curriculum that aims to provide students with hands-on experience on sequencers. It is an even more difficult task to accomplish if one’s purpose was to set such curriculum in a field situation. However, in recent years, educators have seen possibility to bring Next-Generation Sequencing to the reach of students more easily, with the Oxford Nanopore MinION, a low-budget, user-friendly, hand-held sequencer. Academic researchers have illustrated the performances of this device in the field and are inspirational for curricula aiming to take the next generation of scientists in the outdoors. We designed a modular 5-day workshop, with nanopore sequencing to be performed in field conditions. Here we describe the material and methods that lead the students and instructors from sample collection, DNA extraction and preparation for nanopore sequencing with MinION to real-time analysis of the data collected. This curriculum was implemented for the first-time aboard Research Vessel Sikuliaq during a transit organized by the STEMSEAS program at Columbia University in collaboration with the University of Alaska BLaST program. The line of investigation formulated for the workshop was an open-ended question that led the students to establish a proof of concept in terms of technology deployment at sea: what will show metagenomic results from DNA obtained from sea water and sequenced with Oxford Nanopore MinION? The workshop took place in October 2018 while Research Vessel Sikuliaq sailed the Alaskans seas for 7 days. Students successfully used nanopore sequencing for multiple metagenomic seawater samples. Their introductory analysis was consistent with environmental conditions and they were able to present their results by the end of the workshop.

Preprint REVIEW | doi:10.20944/preprints201809.0161.v1

Copper Metabolism of Newborns Is Adapted to Milk Ceruloplasmin As a Nutritive Source of Copper

Ludmila V. Puchkova, Polina S. Babich, Yulia A. Zatulovskaia, Ekaterina Y. Ilyechova, Francesca Di Sole

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: embryonic type copper metabolism; milk ceruloplasmin; baby formula

Online: 10 September 2018 (09:43:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0374.v1

Biochemical Properties of a Decoy Oligodeoxynucleotide Inhibitor of STAT3 Transcription Factor

David S. Lee, Rachel A. O'Keefe, Patrick K. Ha, Jennifer R. Grandis, Daniel E. Johnson

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: STAT3 as a drug target; cyclic STAT3 decoy; oligodeoxynucleotide inhibitor; head and neck cancer

Online: 29 April 2018 (10:10:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0057.v1

The Fracture of Plasma-Treated Polyurethane Surface under Fatigue Loading

Ilya A. Morozov, Alexander S. Mamaev, Mikhail V. Bannikov, Anton Yu. Beliaev, Irina V. Osorgina

Subject: Chemistry And Materials Science, Surfaces, Coatings And Films Keywords: ion plasma treatment; fatigue loading; fracture; polyurethane; surface morphology

Online: 8 January 2018 (09:48:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints201712.0123.v1

Relationship of Work Context and Work Stress among Sonographers in Riyadh, KSA

Uzma Zaidi, Lena F. Hammad, Salwa S. Awad, Safaa M. A. Elkholi, Hind D. Qasem

Subject: Social Sciences, Psychology Keywords: work context; work conditions; work stress; job satisfaction; lifestyle; sonographers; ergonomics

Online: 18 December 2017 (11:53:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.1838.v1

Factors Associated with Anxiety Symptoms Among Filipino Farmers in Central Luzon: An Analytical Cross-sectional Study

Har-li T. Young, Dina Yalong, Vinace S. Guingguing, William, Jr. M. Manengyao, Maria Teresa S. Tolosa, Ma. Beatrice M. Vega, Van Irish S. Ventilacion, Merimae S. Villamayor, Peter G. Villangca, Alina C. Zaño

Subject: Social Sciences, Psychiatry And Mental Health Keywords: Farmers; Agriculture; Central Luzon; Filipino Farmers; Generalized Anxiety Disorder; GAD-7

Online: 28 May 2024 (14:33:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.0831.v1

Impact of Excessive Fructose Intake on the Adipose Tissue and Development of Childhood Obesity

Anna Karenina Azevedo-Martins, Matheus Pedro Santos, Julie Abayomi, Natália Juliana Ramos Ferreira, Fabiana S. Evangelista

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: fructose; childhood obesity; adipose tissue

Online: 13 December 2023 (06:13:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0290.v1

A Deep Learning Framework with Intermediate Layer using Swarm Intelligence Optimizer for diagnosing Oral Squamous Cell Carcinoma

Bharanidharan Nagarajan, Sannasi Chakravarthy S R, Vinoth Kumar V, Mahesh T R, Surbhi Bhatia Khan

Subject: Engineering, Other Keywords: oral cancer; histopathologic images; CNN; deep learning framework; swarm

Online: 6 October 2023 (04:06:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0281.v1

Structural Optimization Design of Microfluidics Chips Based on Fast Sequence Pair Algorithm

Chuang Wu, Jiju Sun, Haithm Yahya Mohammed Almuaalemi, A S M Muhtasim Fuad Sohan, Binfeng Yin

Subject: Engineering, Bioengineering Keywords: microfluidic chip; simulated annealing algorithm; fast sequence pair algorithm; structural design; optimization algorithm

Online: 6 July 2023 (02:37:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0327.v1

Transforming Growth Factor Beta and Epithelial to Mesenchymal Transition Alter Homologous Recombination Repair Gene Expression and Sensitize BRCA Wild Type Ovarian Cancer Cells to Olaparib

Cai M. Roberts, Mehida Rojas-Alexandre, Ruth E. Hanna, Z Ping Lin, Elena S. Ratner

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Ovarian cancer; PARP inhibitors; epithelial to mesenchymal transition; drug response

Online: 13 April 2023 (14:30:07 CEST)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202102.0410.v2

A Modified High-Throughput Screening Protocol to Isolate Bacteriophages from Environmental Samples

Abdallah Abdelsattar, Rana Nofal, Salsabil Makky, Amera El-Sayed, Ayman El-Shibiny

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Phage Purification; phage isolation; phage characterization; jumbo bacteriophages; top agar; double agar overlay; high throughput sequencing

Online: 19 February 2021 (09:53:32 CET)

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Working Paper ARTICLE

MoS₂-on-Paper Optoelectronics: Drawing Photodetectors with Van der Waals Semiconductors Beyond Graphite

Ali Mazaheri, Martin Lee, Herre S. J. van der Zant, Riccardo Frisenda, Andres Castellanos-Gomez

Subject: Chemistry And Materials Science, Nanotechnology Keywords: MoS2; paper electronics; optoelectronics; photodetector

Online: 25 June 2020 (16:16:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.1812.v1

MRD in Acute Leukemias: Lessons Learned from Acute Promyelocytic Leukemia

David Kegyes, Praveena S. Thiagarajan, Gabriel Ghiaur

Subject: Medicine And Pharmacology, Hematology Keywords: acute promyelocytic leukemia; acute myeloid leukemia; acute lymphoblastic leukemia; minimal residual disease

Online: 27 August 2024 (02:51:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.1527.v3

Pathpoint® eDerma: Advancing Teledermatology - A Comprehensive Literature Review and Clinical Evaluation

Balamurugan S, Parisa Zarrighalam, Philip Beak, Piyush Mahapatra

Subject: Public Health And Healthcare, Primary Health Care Keywords: Teledermatology; SaaS Platform; Clinical Evaluation; Parameters and Risk analysis

Online: 14 July 2024 (03:12:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0545.v1

Design and Implementation of Adaptive Deep Learning-Based DC-DC Converters for Photovoltaic Systems with Battery Storage in Electric Vehicles

Chitra Devi S, A Ramkumar

Subject: Engineering, Electrical And Electronic Engineering Keywords: Photovoltaic (PV) Systems; Battery Storage; Electric Vehicles (EVs); DC-DC Converters; Adaptive Deep Learning; Sliding Mode Control (SMC); Convolutional Neural Networks (CNN)

Online: 5 July 2024 (14:48:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.0292.v1

Primary Stabbing Headache in Children and Adolescents

M. Reimers, I. Bonemazzi, F. Brunello, E. Cavaliere, S. Sartori, I. Toldo

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Primary Stabbing Headache; Other Primary Headaches; Children; Adolescents

Online: 4 January 2024 (07:20:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1756.v1

Effects on Soil Chemical Properties Two Years after Application of Compost in a Hedged Olive Grove

Carlos A. Alexandre, Rui Bajouco Lopes, Jacqueline S. Leal, José O. Peça, And António B. Dias

Subject: Environmental And Earth Sciences, Soil Science Keywords: organic amendments; soil organic carbon (SOC); particulate organic matter (POM-C); permanganate oxidizable carbon (POX-C); C-stock; micronutrients cations

Online: 26 June 2023 (07:13:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0478.v1

Leaping Forward or Crawling Backward? Efforts and Biases in Amphibian and Reptile Research on a Megadiverse Faunal Region in the Philippines

Sumaira S. Abdullah, Kier Celestial Dela Cruz, Lothy F. Casim, Angelo Rellama Agduma, Krizler Cejuela Tanalgo

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Amphibians; Conservation; Islands; Philippines; Priorities.

Online: 7 June 2023 (08:06:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0051.v1

Genetic Knockouts Indicate That the ABCC2 Gene in the Bollworm Helicoverpa Zea Is Not a Major Receptor for the Cry1Ac Insecticidal Protein.

Omaththage P. Perera, Nathan S LIttle, Heba Abdelgaffar, Juan Luis Jurat-Fuentes, Gadi V. P. Reddy

Subject: Biology And Life Sciences, Insect Science Keywords: Helicoverpa zea; Bollworm; CRISPR; Cry1A; Bt Toxin; Genome Editing; Knockout; Functional Genomics; Resistance

Online: 3 September 2021 (08:19:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0237.v1

Rapid Colorimetric Detection of Genome Evolution in SCRaMbLEd Synthetic Saccharomyces cerevisiae Strains

Elizabeth L. I. Wightman, Heinrich Kroukamp, Isak S. Pretorius, Ian T. Paulsen, Helena K. M. Nevalainen

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Saccharomyces cerevisiae; SCRaMbLE; genome evolution; industrial yeast strains

Online: 6 November 2020 (10:30:45 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202001.0292.v1

Summary: Chemical Modulation of Circadian Rhythms and Assessment of Cellular Behavior via Indirubin and Derivatives

Hui-Hsien Lin, Kelly L. Robertson, Sujeewa S. Lellupitiyage Don, Stephanie R. Taylor, Michelle E. Farkas

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: circadian rhythms; small molecules; luciferase reporters; period estimations

Online: 25 January 2020 (00:33:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints201910.0330.v1

Establishment and Characterization of a Murine Mucosal Mast Cell Culture Model

Aya Kakinoki, Tsuyoshi Kameo, Shoko Yamashita, Kazuyuki Furuta, Satoshi Tanaka

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: mast cell; il-9; chymase; histamine; atp

Online: 29 October 2019 (10:23:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints201902.0064.v1

A Complete Assessment of Dopamine Receptor-Ligand Interactions through Computational Methods

Beatriz Bueschbell, Carlos A.V. Barreto, Antonio J. Preto, Anke C. Schiedel, Irina S. Moreira

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Dopamine receptors, Molecular Docking, Molecular Dynamics, Receptor-Ligand Interactions

Online: 6 February 2019 (13:54:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0206.v1

Temporal Limits of Visual Motion Processing: Psychophysics and Neurophysiology

Bart G. Borghuis, Duje Tadin, Martin J.M. Lankheet, Joseph S. Lappin, Wim A. van de Grind

Subject: Social Sciences, Behavior Sciences Keywords: human psychophysics; apparent motion; temporal integration; cat; retina; neural coding; Hassenstein-Reichardt detector; model analysis

Online: 10 October 2018 (06:31:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201706.0058.v1

Portable Multispectral Colorimeter for Metallic Ions Detection and Classification

Mauro S. Braga, Ruth F. V. V. Jaimes, Walter Borysow, Osmar F. Gomes, Walter J. Salcedo

Subject: Engineering, Electrical And Electronic Engineering Keywords: portable environmental monitoring systems; metallic ions detection; colorimetric system

Online: 13 June 2017 (06:16:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1384.v2

QRGB: App for QR Code Generation (3-in-1 Method), Additive Color Generation Method (RGB), Using Python Programming Code, to Increase Accumulated Information Density

Ibar Anderson

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: App; Color; RGB; Codes QR; Python

Online: 19 July 2024 (10:34:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1171.v1

Exploring the Role of Thy-1 and Its Soluble Form regarding Fibrosis Severity in Primary Biliary Cholangitis and Metabolic Dysfunction-Associated Fatty Liver Disease

Mirjam Kolev, Anja Saalbach, Rahel Bütikofer, Florian Kollert, Matteo Montani, Nasser Semmo

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: liver fibrosis; primary biliary cholangitis; metabolic dysfunction-associated liver disease; Thy-1; soluble Thy-1

Online: 17 May 2024 (11:03:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1318.v1

Improving Self-Efficacy, Quality of Life and Glycemic Control in Adolescents with Type 1 Diabetes: An Experimental Evaluation of the Family Centered Empowerment Model

Salah Alzawahreh, Candan Ozturk

Subject: Public Health And Healthcare, Nursing Keywords: adolescents; family-centered empowerment model; glycemic control; quality of life; self-efficacy; type 1 Diabetes mellitus (T1DM)

Online: 22 April 2024 (12:16:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0599.v1

Long-Term and seasonal changes in Emission Sources of Atmospheric Particulate-Bound Pyrene and 1-Nitropyrene in Selected Four Cities in the Western Pacific

Kazuichi Hayakawa

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Western Pacific; vehicle; coal combustion; source contribution; pyrene; 1-nitropyrene

Online: 9 April 2024 (07:46:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0562.v1

Accurate Diagnosis of SARS-CoV-2 JN.1 by Sanger Sequencing of Receptor-Binding Domain Is Needed for Clinical Evaluation of Its Immune Evasion

Sin Hang Lee

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Omicron JN.1; SARS-CoV-2; Sanger sequencing; RBD; L455S mutation; immune evasion; vaccination policies; CDC

Online: 11 March 2024 (09:02:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0279.v1

In Vitro Combinatorial Activity of Direct Acting Antivirals and Monoclonal Antibodies against the Ancestral B.1 and BQ.1.1 SARS-CoV-2 Viral Variants

Lia Fiaschi, Camilla Biba, Ilenia Varasi, Niccolò Bartolini, Chiara Paletti, Federica Giammarino, Francesco Saladini, Maurizio Zazzi, Ilaria Vicenti

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; mAbs; DAA; Combination antiviral therapy; In vitro synergism; Omicron variant

Online: 3 January 2024 (19:28:07 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202312.0823.v1

A Case Report of Secondary Glaucoma in a Patient With HTLV-1-Discussion About the Management of Secondary Glaucoma Due to Recurrent Granulomatous Uveitis?

Teruhiko Hamanaka, Kenta Ashikaga, Mayumi Hosogai, Takao Tanaka, Shintaro Nakao, Toshinari Funaki

Subject: Physical Sciences, Biophysics Keywords: HTLV-1; secondary glaucoma; uveitis; glaucoma-drainage-implant

Online: 12 December 2023 (07:25:34 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202311.0678.v1

Chromosomal Translocations t(1; 22)(q21; q11.2) and t(6; 18)(p25; q21) in a Patient with Diffuse Large B-cell Lymphoma: FISH Analysis

Hiroaki Kitamura, Yasushi Kubota, Ichiro Hanamura, Sivasundaram Karnan, Rika Tomimasu, Michiaki Akashi, Shiho Tsuruda, Akiyoshi Takami, Shinya Kimura, Masaharu Miyahara

Subject: Medicine And Pharmacology, Hematology Keywords: diffuse large B-cell lymphoma; fluorescence in situ hybridization; 1q21; immunoglobulin lambda; BCL2

Online: 10 November 2023 (07:25:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1414.v1

PNA6, a Lactosyl Analogue of Angiotensin-(1—7), Reverses Pain Induced in Murine Models of Inflammation, Metastatic Bone Disease, and Chemotherapy-Induced Peripheral Neuropathy

Maha Sulaiman, Wafaa Alabsi, Lajos Szabo, Meredith Hay, Robin Polt, Tally Largent-Milnes, Todd Vanderah

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: PNA6; angiotensin 1-7; Mas receptor; breast; cancer; pain

Online: 21 August 2023 (07:18:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0788.v1

Clinical Performance of the Gore Septal Occluder in Patent Foramen Ovale Closure in Different Septal Anatomies: 1 Year- Results From a Single-Center Experience

Giuseppe Verolino, Dario Calderone, Mara Gavazzoni, Davide Sala, Paolo Sganzerla

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: patent foramen ovale; complex PFO anatomy; GSO; long-term residual shunt

Online: 12 July 2023 (07:55:03 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202301.0310.v1

Small RNA Profiling in HTLV-1-infected Patient with Acute Adult T-cell Leukemia-Lymphoma at Diagnosis and After Maintenance Therapy: A Case Study

Rodrigo Pessôa, Daniela R. V. Souza, Youko Nukui, Juliana Pereira, Augusto César Penalva de Oliveira, Jorge Casseb, Alberto José da Silva Duarte, Sabri Saeed Sanabani

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: small RNA; HTLV-1; ATLL; massive parallel sequencing

Online: 17 January 2023 (11:06:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0152.v1

Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Massimo Sangiorgi, Mariangela Valentina Puci, Allegra Rosa Martelli, Teresa Messina, Paolo Frigatti, Maria Pia Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco Michelino Fiore, Armado Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, Diego Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Pietro Modugno, Maurizio Maiorano, Umberto Marcello Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, Giovanni Maria Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munaó, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio Stefano Tolva, Ilenia D'Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D'Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio Massimo Oddi, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: chronic limb-threatening ischemia; outcome; sex; age; limb salvage

Online: 8 December 2022 (09:39:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0180.v1

Sustainability of C-Reactive Protein (CRP) Apheresis in Acute Myocardial Infarction (AMI) - Results from a Supplementary Data Analysis of the Explorative CAMI-1 Study

Horst Skarabis, Jan Torzewski, Wolfgang Ries, Franz Heigl, Christoph D. Garlichs, Rudolf Kunze, Ahmed Sheriff

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: C-reactive protein; STEMI; AMI; CRP apheresis; CMR; MRI; infarct size; inflammation; inflammatory mediators; ischaemia; hypoxia; phagocytosis

Online: 12 October 2022 (13:41:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0134.v1

Overexpression of ErbB-1 (EGFR) Protein in Eutopic Endome-Trium of Infertile Women with Severe Ovarian Endometriosis during the ‘Implantation Window’ of Menstrual Cycle

Jeevitha Poorasamy, Deepali Garg, Juhi Bharti, Aruna Nambirajan, Asmita Patil, Jayasree Sengupta, Debabrata Ghosh

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: endometriosis; endometrium; ErbB receptors; immunoprecipitation; implantation stage; infertility

Online: 11 October 2022 (03:30:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0347.v1

Increased Autoimmune Responses to Oxidative Specific Epitopes in Bipolar Disorder Type 1 and Major Depression: Towards A Data-Driven, Mechanistic Model of Mood Disorders

Drozdstoy Stoyanov, Jean–Claude Leunis, Marianna Murdjeva, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: mood disorders; depression; nitrosative and oxidative stress; IgM autoimmunity; neuro-immune; inflammation

Online: 16 September 2020 (04:17:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201910.0236.v1

Prostate-Derived ETS Factor (PDEF) Regulates Yes Associated Protein 1 (YAP1) in Prostate Cancer Cells: A Potential Cross-Talk between PDEF and Hippo Signaling

Praveen Kumar Jaiswal, Suman Mohajan, Sweaty Koul, Fengtian Wang, Runhua Shi, Hari K. Koul

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: YAP1; PDEF; prostate cancer

Online: 20 October 2019 (16:18:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0293.v1

Increased Serum Immunoglobulin Responses to Gut Commensal Gram-Negative Bacteria in Unipolar Major Depression and Bipolar Disorder Type 1, Especially When Melancholia is Present

Denitsa Simeonova, Drozdstoy Stoyanov, Jean–Claude Leunis, Andre F. Carvalho, Marta Kubera, Marianna Murdjeva, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; bipolar disorder; gut; bacterial translocation; LPS; oxidative stress; neuro-immune; immunology; psychiatry

Online: 26 July 2019 (00:38:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201906.0155.v1

Carboplatin Enhances the Activity of Human Transient Receptor Potential Ankyrin 1 through the Cyclic AMP-Protein Kinase A-A-Kinase Anchoring Protein (AKAP) Pathways

Kanako Miyano, Seiji Shiraishi, Koichiro Minami, Yuka Sudo, Masami Suzuki, Toru Yokoyama, Kiyoshi Terawaki, Miki Nonaka, Hiroaki Murata, Yoshikazu Higami, Yasuhito Uezono

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: carboplatin; CIPN; TRPA1; cAMP; PKA; AKAP

Online: 17 June 2019 (09:53:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.2107.v2

Harnessing Biopolymer Gels for Theranostic Applications: Imaging Agent Integration and Real-Time Monitoring of Drug Delivery

Pranita S Jirvankar, Surendra S Agrawal, Nikhita Chambhare, Rishabh Agrawal

Subject: Medicine And Pharmacology, Pharmacy Keywords: Biopolymer gel; Real-Time monitoring; Imaging agent

Online: 9 July 2024 (12:29:28 CEST)

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