ARTICLE
|
doi:10.20944/preprints202405.1338.v1
Subject:
Biology And Life Sciences,
Life Sciences
Keywords:
tumor necrosis factor-related apoptosis-inducing ligand; gintonin-enriched fraction; human renal cell carcinoma; apoptosis; mu-2-related death-inducing gene
Online: 21 May 2024 (04:53:52 CEST)
ARTICLE
|
doi:10.20944/preprints202404.1663.v1
Subject:
Biology And Life Sciences,
Behavioral Sciences
Keywords:
Drosophila melanogaster model of fragile X syndrome; FMR1 gene; fragile X syndrome; social anxiety; social interaction; social network analysis
Online: 25 April 2024 (14:25:46 CEST)
REVIEW
|
doi:10.20944/preprints202403.0188.v1
Subject:
Biology And Life Sciences,
Biophysics
Keywords:
Keywords: Hox gene collinearity; temporal collinearity; Noether Theory; self similarity; double strand break; split Hox clusters; chicken limb growth.
Online: 5 March 2024 (09:11:25 CET)
REVIEW
|
doi:10.20944/preprints202309.2000.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Cluster of differentiation 74 (CD74); oncogenic fusion protein; fusion gene; CD74-ROS1; CD74-NTRK1; CD74-NRG1; CD74-NRG2a; CD74-PDGFRB; cancer.
Online: 29 September 2023 (04:35:12 CEST)
REVIEW
|
doi:10.20944/preprints202309.0482.v1
Subject:
Biology And Life Sciences,
Agricultural Science And Agronomy
Keywords:
Alternative splicing; biological rhythms; domestication and polyploidization; gene mining; heterosis; nutrient homeostasis; plant phenology and architecture; symbiosis; transcriptome and proteome diversity
Online: 7 September 2023 (09:30:00 CEST)
REVIEW
|
doi:10.20944/preprints202305.1229.v1
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
Molecular Genetics; Neurodegenerative Disease; Molecular pathology; Epigenetics; Gene expression; Therapeutic targets; Biomarkers; Alzheimer’s Disease; Parkinson’s Disease; Huntington Disease; Amyotrphic Lateral Sclerosis
Online: 17 May 2023 (10:28:26 CEST)
REVIEW
|
doi:10.20944/preprints202206.0370.v1
Subject:
Biology And Life Sciences,
Life Sciences
Keywords:
GADV hypothesis; origin of life; protein 0th-order structure; origin of protein; [GADV]-microsphere; origin of gene: the core life system
Online: 28 June 2022 (03:41:15 CEST)
REVIEW
|
doi:10.20944/preprints202201.0073.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Messenger RNA • Hospital-based mRNA therapeutics • circular mRNA • self-amplifying mRNA • RNA-based CAR T-cell • RNA-based gene-editing tools
Online: 6 January 2022 (11:20:59 CET)
ARTICLE
|
doi:10.20944/preprints202011.0640.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Arthroplasty; prosthetic joint replacement; prosthetic joint infection; systemic antibiotic prophylaxis; Antibiotics; chlorhexidine gluconate; coagulase-negative staphylococci; tuf gene sequencing; staphylome; microbiome
Online: 25 November 2020 (12:56:25 CET)
ARTICLE
|
doi:10.20944/preprints201906.0198.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
papillary thyroid cancer; BCPAP cells; 8505C cells; prostate cancer; LNCaP cells; DU145 cells; kidney cancer; HL-60 cells; cancer gene software
Online: 20 June 2019 (10:28:48 CEST)
ARTICLE
|
doi:10.20944/preprints202407.0361.v1
Subject:
Biology And Life Sciences,
Life Sciences
Keywords:
Metachromadora parobscura sp. nov.; Molgolaimus longicaudatus sp. nov.; taxonomy; Beibu Gulf of the South China Sea; Small subunit (SSU) 18S rDNA gene
Online: 4 July 2024 (09:07:04 CEST)
REVIEW
|
doi:10.20944/preprints202401.1912.v1
Subject:
Biology And Life Sciences,
Life Sciences
Keywords:
Enzyme functions; domains of unknown functions; central metabolic pathways; biosynthesis; biosynthetic gene clusters; cryptic pathways; orphan pathways; silent pathways; metabolite repair enzymes
Online: 26 January 2024 (11:07:28 CET)
REVIEW
|
doi:10.20944/preprints202307.1624.v1
Subject:
Biology And Life Sciences,
Life Sciences
Keywords:
origin of gene; anticodon stem-loop tRNA (AntiC-SL tRNA); immature [GADV]-protein; protein 0th-order structure; origin of life; GADV hypothesis
Online: 25 July 2023 (07:30:18 CEST)
ARTICLE
|
doi:10.20944/preprints202305.0848.v1
Subject:
Biology And Life Sciences,
Neuroscience And Neurology
Keywords:
ON-Bipolar cells; optogenetic gene therapy; Kv1.3 channel; Psora-4; retinal degeneration; vision restoration; Opto-mGluR6; patch clamp; multi-electrode array recordings.
Online: 11 May 2023 (11:34:36 CEST)
ARTICLE
|
doi:10.20944/preprints202207.0272.v1
Subject:
Engineering,
Electrical And Electronic Engineering
Keywords:
localized electroporation; gene electrotransfer; plasmid; transfection; cell culture insert; numerical modeling; Chinese hamster ovary cells; myoblasts; C2C12 cell line; H9C2 cell line
Online: 19 July 2022 (02:28:54 CEST)
ARTICLE
|
doi:10.20944/preprints202101.0390.v1
Subject:
Biology And Life Sciences,
Anatomy And Physiology
Keywords:
protein structure; relative solvent accessibility; secondary structure; phylogeny; models of sequence evolution; gene tree-species tree discordance; incomplete lineage sorting; Ctenophora; Porifera
Online: 19 January 2021 (16:46:25 CET)
ARTICLE
|
doi:10.20944/preprints202012.0252.v1
Subject:
Social Sciences,
Psychology
Keywords:
Fear extinction; Fear Conditioning; Medial Prefrontal Cortex; RNA sequencing; Differential Gene Expression; Electrophysiological Recordings; Excitatory Post-Synaptic Currents; Spinogenesis; Fear-related Disorders
Online: 10 December 2020 (11:38:50 CET)
ARTICLE
Subject:
Biology And Life Sciences,
Animal Science, Veterinary Science And Zoology
Keywords:
feminine hygiene; feminine gel wash; lactic acid; vulvar skin pH; vulvar microbiome; skin microflora; vulvovaginal environment; bacterial 16S rRNA gene; fungal ITS
Online: 9 December 2019 (03:53:52 CET)
ARTICLE
|
doi:10.20944/preprints201806.0310.v2
Subject:
Medicine And Pharmacology,
Dietetics And Nutrition
Keywords:
non-alcoholic fatty liver disease; steatosis; NASH; gene set enrichment analysis; green tea; methionine-choline deficient diet; γ-linolenate biosynthesis_Homo sapiens_PWY-6000
Online: 29 September 2018 (07:53:35 CEST)
REVIEW
|
doi:10.20944/preprints202405.2001.v1
Subject:
Biology And Life Sciences,
Plant Sciences
Keywords:
mosaic-virus; novel viruses; pathogen-derived resistance; RNAi; artificial microRNA; plant gene editing; NB-LRR protein; nanoparticle RNA delivery; plant disease; crop protection
Online: 30 May 2024 (10:51:19 CEST)
REVIEW
|
doi:10.20944/preprints202402.1673.v1
Subject:
Medicine And Pharmacology,
Clinical Medicine
Keywords:
systemic amyloidosis; hereditary transthyretin amyloid; immunoglobulin light chain amyloid; transthyretin gene variant carrier; biomarker; neurofilament light chain; polyneuropathy; small fiber neuropathy; autonomic neuropathy
Online: 29 February 2024 (10:42:35 CET)
COMMUNICATION
|
doi:10.20944/preprints202402.0777.v1
Subject:
Biology And Life Sciences,
Animal Science, Veterinary Science And Zoology
Keywords:
Toxoplasma gondii; pig genetic resistance; interleukin-18 gene; immunity pathway; serological sur-vey; pork meat safety; alternative prevention measures; novel investigation; One Health
Online: 14 February 2024 (05:35:06 CET)
REVIEW
|
doi:10.20944/preprints202401.2227.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
Cytolytic Activity (CYT); Tumor-Infiltrating Lymphocytes (TILs); Gene Expression Profiling; Spatial Analysis Techniques; Immune Checkpoint Pathways; Tumor Microenvironment (TME); Antigen Presentation; Metabolic Pathways
Online: 31 January 2024 (12:32:26 CET)
ARTICLE
|
doi:10.20944/preprints202312.1576.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
16S rRNA gene amplicon sequencing; adverse effects; bacterial contamination; fluorescent staining; masks; N95; personal protective equipment; risk; surgical mask
Online: 20 December 2023 (15:14:56 CET)
ARTICLE
|
doi:10.20944/preprints202202.0118.v1
Subject:
Chemistry And Materials Science,
Analytical Chemistry
Keywords:
protein-DNA interactions; DNA recognition; transcription factors; DNA binding domains; con-formational change; nuclear magnetic resonance; circular dichroism; control of gene expression; homeodomains.
Online: 8 February 2022 (14:53:06 CET)
ARTICLE
|
doi:10.20944/preprints202012.0637.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
miRNA; gene targets; intronic miRNA; miRNA prediction; human miRNAs; PHEX miRNAs; chimpanzee homologues; experimentally-validated miRNA targets; miRNA computational survey; miRNA target multiplicity
Online: 24 December 2020 (15:30:33 CET)
ARTICLE
|
doi:10.20944/preprints202406.0009.v1
Subject:
Medicine And Pharmacology,
Pulmonary And Respiratory Medicine
Keywords:
EGFR mutation; osimertinib; acquired resistance; secondary mutations; novel drugs; non-small cell lung cancer; epithelial to mesenchymal transition; MET gene amplification; Ba/F3 cells
Online: 4 June 2024 (02:53:41 CEST)
REVIEW
|
doi:10.20944/preprints202309.0459.v2
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
migraine disorders; headache disorders; nociceptive pain; analgesics; calcitonin gene-related peptide; pituitary adenylate cyclase-activating polypeptide (PACAP); vasoactive intestinal peptide; adrenomedullin; neuropeptides; drug development
Online: 17 October 2023 (10:50:15 CEST)
ARTICLE
|
doi:10.20944/preprints202205.0280.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
purine-rich element binding protein A gene; PURA; MIM: 600473; transcriptional activator protein Pur-alpha; cognitive developmental delay; mental retardation; Mutation c.697_699del p.Phe233del
Online: 20 May 2022 (16:58:04 CEST)
ARTICLE
|
doi:10.20944/preprints201912.0399.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
natural product; actinobacteria; quorum sensing inhibition (QSI); biosynthetic gene clusters (BGCs); global natural product social networking (GNPS); cyclic dipeptides (2,5-diketopiperazines, DKPs); LC-HRMS
Online: 31 December 2019 (02:59:59 CET)
REVIEW
|
doi:10.20944/preprints201912.0021.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
protein 0th-order structure; origin of gene; origin of protein; origin of genetic code; GNC primeval genetic code hypothesis; SNS primitive genetic code hypothesis
Online: 3 December 2019 (11:10:12 CET)
REVIEW
|
doi:10.20944/preprints201712.0170.v1
Subject:
Biology And Life Sciences,
Life Sciences
Keywords:
RNA world; [GADV]-protein world; GADV hypothesis; origin of life; protein 0th-order structure; origin of protein; origin of genetic code; origin of gene
Online: 25 December 2017 (08:08:37 CET)
REVIEW
|
doi:10.20944/preprints202406.2068.v1
Subject:
Biology And Life Sciences,
Neuroscience And Neurology
Keywords:
spinal muscular atrophy (SMA); survival of motor neuron 1 (SMN1); SMN2; SMN protein; antisense oligonucleotide (ASO); nusinersen; gene therapy; onasemnogene; risdiplam; small molecule; combination therapy
Online: 29 June 2024 (06:33:01 CEST)
ARTICLE
|
doi:10.20944/preprints202403.0001.v1
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
antibiotic resistance; antibiotic resistance genes; hospital indoor environment; microbial communities; high-throughput qPCR; department-specific; tap water; p-trap water; air dust; mobile gene elements
Online: 1 March 2024 (00:21:18 CET)
ARTICLE
|
doi:10.20944/preprints202306.1866.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
Sesamum orientale L. cv. “Gökova”; L929 fibroblast cells; A549 lung epithelial cells; MCF-7 breast epithelial cells; Cisplatin; BCL-XL gene; Cas3 and Cas9 genes
Online: 27 June 2023 (09:08:02 CEST)
REVIEW
|
doi:10.20944/preprints202305.1430.v1
Subject:
Biology And Life Sciences,
Agricultural Science And Agronomy
Keywords:
Oryza sativa; Magnaporthe oryzae; rice; rice blast; panicle blast; high field resistance; quantitative resistance; major gene; adult plant resistance; durability; sustainable use; sustainable development goals
Online: 19 May 2023 (10:30:25 CEST)
REVIEW
|
doi:10.20944/preprints202103.0373.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Mesenchymal stem/stromal cells; regenerative medicine; tissue engineering; Clinical Application; Differentiation Capacity; Cellular Immunomodulation; Inflammation; Signaling Cells; Transplantation; International Society for Cell and Gene Therapy
Online: 15 March 2021 (11:51:28 CET)
ARTICLE
|
doi:10.20944/preprints202405.0159.v1
Subject:
Medicine And Pharmacology,
Ophthalmology
Keywords:
glaucoma; primary open-angle glaucoma; POAG; trabecular meshwork; intra-ocular pressure; pseudoexfoliation glaucoma; microRNA; miRNA; transforming growth factor beta; TGFβ ; fibrosis; epigenetics; gene therapy; therapeutics
Online: 3 May 2024 (11:22:57 CEST)
ARTICLE
|
doi:10.20944/preprints202301.0280.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Fanconi anemia; oral cancer; oral potentially malignant lesion; liquid biopsy; saliva; oral rinse; plasma; next generation sequencing; cancer gene panel; early diagnosis; diagnostic test; deep sequencing
Online: 16 January 2023 (09:10:06 CET)
ARTICLE
Subject:
Biology And Life Sciences,
Anatomy And Physiology
Keywords:
T cell receptor; dolphin genome; TRB locus; TRBV; TRBJ; TRBD and TRBC genes; TRA and TRB gene expression analysis; multiple sequence alignments (MSA); 3D modelisation; IMGT
Online: 11 February 2021 (13:26:26 CET)
REVIEW
|
doi:10.20944/preprints201809.0217.v1
Subject:
Biology And Life Sciences,
Cell And Developmental Biology
Keywords:
Premature ovarian insufficiency, POI; Gene therapy; Menopause; SAL-like 4 genes, SALL4; Follicle-stimulating hormone (FSH); Basonuclin-1; Replication-incompetent adenoviral vector, Ad; Stem cells, SC.
Online: 12 September 2018 (11:06:42 CEST)
ARTICLE
|
doi:10.20944/preprints201809.0082.v1
Subject:
Medicine And Pharmacology,
Cardiac And Cardiovascular Systems
Keywords:
atherosclerosis; coronary aortic disease; gene set enrichment analysis; heart disease; Apoe mouse; transcriptomics; RNA-seq analysis; pathway enrichment analysis; mouse; precision medicine; New Zealand White rabbit
Online: 5 September 2018 (04:49:40 CEST)
ARTICLE
|
doi:10.20944/preprints202403.0324.v1
Subject:
Medicine And Pharmacology,
Epidemiology And Infectious Diseases
Keywords:
S. pneumoniae; erythromycin; AMR; MSC (minimal selective concentration); G. mellonella; ADI (acceptable daily intake); MRL (maximum residue limit); HGT (horizontal gene transfer)
Online: 6 March 2024 (10:03:26 CET)
REVIEW
|
doi:10.20944/preprints202401.0237.v1
Subject:
Medicine And Pharmacology,
Cardiac And Cardiovascular Systems
Keywords:
congenital heart disease; first heart field; second heart field; whole exome sequencing; whole genome sequencing; loss-of-function variant; copy number variants; gene variants; deletion; de novo mutations
Online: 3 January 2024 (11:57:54 CET)
ARTICLE
|
doi:10.20944/preprints202007.0408.v1
Subject:
Biology And Life Sciences,
Cell And Developmental Biology
Keywords:
Wharton’s Jelly human umbilical cord mesenchymal stem cells (hWJ-MSCs); Growth Differentiation Factor-5; human bone marrow Mesenchymal Stem Cells (hBM-MSCs); tenogenic commitment; gene expression; immunofluorescence assay
Online: 19 July 2020 (11:02:01 CEST)
ARTICLE
|
doi:10.20944/preprints201910.0238.v1
Subject:
Computer Science And Mathematics,
Artificial Intelligence And Machine Learning
Keywords:
hybrid machine learning model; transportation infrastructure; flexible pavement; remaining service life prediction; pavement condition index; support vector regression; fruit fly optimization algorithm (foa); gene expression programming (gep); svr-foa
Online: 20 October 2019 (17:11:10 CEST)
ARTICLE
|
doi:10.20944/preprints202307.0519.v1
Subject:
Engineering,
Bioengineering
Keywords:
Lung cancer classification; dimensionality reduction; feature selection techniques; STFT; Particle Swarm Optimization; Harmonic Search; Non-Linear Regression; Mixture Model; Convolutional Neural Network (CNN) for Lung Cancer; Microarray gene expression dataset
Online: 7 July 2023 (16:30:59 CEST)
ARTICLE
|
doi:10.20944/preprints202405.1606.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Oral squamous cell carcinoma; OSCC; oral cancer; miRNA; miRNA expression; genes; gene expression; hyperplasia; dysplasia; early invasion; early stage OSCC; in situ carcinoma; precancerous lesions; animal model; early diagnosis; liquid biopsy
Online: 24 May 2024 (08:38:17 CEST)
REVIEW
|
doi:10.20944/preprints201811.0018.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Duchenne muscular dystrophy (DMD); CRISPR/Cas9; exon skipping therapy; gene editing; human induced pluripotent stem cells (hiPSCs); immortalized patient muscle cells; mdx mice; humanized dystrophic mouse models; deltaE50-MD dog model
Online: 2 November 2018 (05:14:23 CET)
REVIEW
|
doi:10.20944/preprints202311.0383.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
ACD; asymmetric cell division; AMF; amoebozoa; metazoa and fungi; DSCD; defective symmetric cell division; GRN; gene regulatory network; MGRS; multinucleated genome repair syncytium; NG; non-gametogenic germline; PGCC; polyploid giant cancer cell
Online: 7 November 2023 (11:39:43 CET)
ARTICLE
|
doi:10.20944/preprints202103.0658.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
Pancreatic cancer; RNAseq; Humans; Weight loss; Prognosis; Rectus Abdominis; Carcinoma, Pancreatic Ductal; Adipose Tissue; Pancreatic Carcinoma; Pancreatic Neoplasms; Subcutaneous Fat; High-Throughput Nucleotide Sequencing; Body Composition; Muscles; Cachexia; Muscular Atrophy; Gene Expression
Online: 26 March 2021 (11:24:10 CET)
ARTICLE
|
doi:10.20944/preprints202004.0509.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
nodal peripheral T-cell lymphomas; peripheral T-cell lymphoma, not otherwise specified (PTCL/NOS); ALK-negative anaplastic large-cell lymphoma (ALCL/ALK-); Angioimmunoblastic T-cell lymphoma (AITL); diagnosis; prognosis; GATA3 gene expression
Online: 29 April 2020 (12:48:00 CEST)
REVIEW
|
doi:10.20944/preprints202305.1344.v1
Subject:
Medicine And Pharmacology,
Pathology And Pathobiology
Keywords:
mediastinal gray-zone lymphoma; classical Hodgkin lymphoma; primary mediastinal B-cell lymphoma; diffuse large B-cell lymphoma; NOS; EBV-positive diffuse large B-cell lymphoma; NOS; morphology; phenotype; gene expression profile; mutational landscape
Online: 18 May 2023 (12:25:07 CEST)
ARTICLE
|
doi:10.20944/preprints202305.0339.v1
Subject:
Biology And Life Sciences,
Plant Sciences
Keywords:
Banana; fine mapping; quantitative trait locus; Musa acuminata ssp. malaccensis; Fusarium wilt; Fusarium oxysporum f. sp. cubense; Tropical Race 4; Subtropical Race 4; marker assisted selection; resistance gene expression; receptor-like kinase; RNAseq
Online: 5 May 2023 (09:51:49 CEST)
REVIEW
|
doi:10.20944/preprints202210.0248.v1
Subject:
Biology And Life Sciences,
Aging
Keywords:
Trade-off of survival for reproduction; natural selection of aging; regulatory redundancy; aging’s individual benefit; regulatory molecular biology; Darwin’s dilemma; aging-reproduction trade-off; aging declines force of selection; master gene; holistic regulatory mechanism
Online: 18 October 2022 (04:36:09 CEST)
REVIEW
|
doi:10.20944/preprints202010.0578.v1
Subject:
Biology And Life Sciences,
Anatomy And Physiology
Keywords:
Type 1 diabetes; insulin therapy; C-peptide; islet transplantation, mesenchymal stem cells; induced pluripotent stem cells; pancreatic β cell; gene therapy; β-cell regeneration and reprogramming, type 1 diabetes precision medicine, diabetes personalized care.
Online: 28 October 2020 (10:02:34 CET)
ARTICLE
Subject:
Environmental And Earth Sciences,
Paleontology
Keywords:
protein/RNA world: plasma membrane; cytoplasm; gene regulation; virus world; pre-retro virus; emergence of DNA; transcription and replication; first cells; hyperthermophiles; LUCA; Bacteria and Archaea; anoxygenic bacteria; oxygenic bacteria; global distribution of cyanobacteria
Online: 12 February 2020 (03:25:07 CET)
ARTICLE
|
doi:10.20944/preprints202105.0646.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
Torg-Winchester Syndrome; Torg syndrome; MONA syndrome; Nodulosis-Arthropathy-Osteolysis syndrome; Al-Aqeel Sewairi Syndrome; Matrix Metalloproteinase 14; MMP2 gene mutations; Osteochondrodysplasia; genetic skeletal dysplasia; Frank-Ter Haar syndrome; Multicentric carpotarsal osteolysis syndrome; Childhood osteoporosis.
Online: 26 May 2021 (15:02:22 CEST)