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Preprint ARTICLE | doi:10.20944/preprints202305.1171.v1

Topical Application of Autologous Peripheral Blood Mononuclear Cells in Patients with Small Artery Disease and Diabetic Foot Ulcers: Efficacy, Safety and Economic Evaluation

Benedetta Ragghianti, Bianca Maria Berardi, Edoardo Mannucci, Matteo Monami

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Diabetes mellitus; Foot ulcer; Cell-therapy; Small Artery Disease; Chronic Limb-Threatening Ischemia; Economic evaluation

Online: 17 May 2023 (02:41:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0562.v1

Intra-Articular Facet Joint Injection of Normal Saline for Chronic Low Back Pain: A Systematic Review and Meta-Analysis

Areerat Suputtitada, Tanawin Nopsopon, Thanitsara Rittiphairoj, KRIT Pongpirul

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Facet joint injection; Chronic low back pain; Normal saline; Meta-analysis; Patient Reported Clinical Outcomes

Online: 9 May 2023 (04:22:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0358.v1

Prevalence, Location, and Interference with Daily Life of Chronic Pain in Long-Term Survivors after Discharge from a Tertiary Emergency Center

Naoya Hashimoto, Takeshi Unoki, Nozomi Nagano, Ryota Funamizu, Keigo Sawamoto

Subject: Medicine And Pharmacology, Emergency Medicine Keywords: chronic pain; intensive care units; critical care; critical illness; post-intensive care syndrome; emergency medicine

Online: 20 December 2022 (07:45:51 CET)

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Preprint REVIEW | doi:10.20944/preprints202212.0287.v1

Protective Effect of Green Tea (Camellia sinensis) against Kidney Diseases

Luis L. Ayusso, Ana Paula Girol, Emmanuel A. Burdmann

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: green tea; EGCG; oxidative stress; acute kidney injury; chronic kidney disease; kidney stones; diabetic nephropathy

Online: 15 December 2022 (15:48:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202209.0178.v1

A Prospective Cohort Study: Erector Spinae Plane Block Decreases Chronic Postoperative Pain Severity in Patients Undergoing Coronary Artery Bypass Grafting

Marcin Wiech, Sławomir Żurek, Arkadiusz Kurowicki, Beata Horeczy, Mirosław Czczuwar, Paweł Piwowarczyk, Kazimierz Widenka, Michał Borys

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: chronic postoperative pain; erector spinae plane block; coronary artery bypass grafting; Neuropathic Pain Symptom Inventory

Online: 13 September 2022 (11:24:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0137.v1

Machine Learning Classification of Specific Serologic Cytokines May Improve Detection of Recent, Fall Induced, Sub-Concussional Brain Changes in Geriatric Nondemented Subjects

Eduard Drima, Camelia Vrabie

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Chronic geriatric inflammation; machine learning C4.5 classification; brain ventricular volumes; recent fall; subconcussive brain trauma

Online: 9 September 2022 (13:05:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202209.0123.v1

Falls Incidence and Associated Risk Factors among People with Chronic Obstructive Pulmonary Disease (COPD)

Mehrdad Davoudi, Seyyed Mohammadreza Shokouhyan, Mohsen Abedi, Mehdi Rezaei, Mohamad Parnianpour, Kinda Khalaf, Masood Mazaheri

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: chronic obstructive pulmonary disease; COPD; fall risk factor; gait; balance; cognition; daily activity; muscle dysfunction

Online: 8 September 2022 (10:35:01 CEST)

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Chronic obstructive pulmonary disease (COPD) is increasingly being recognized as a systemic disease rather than a mere disorder of the lungs. Central (respiratory) and peripheral (limb) muscle weakness are among the main pronounced systemic effects of COPD. While the disease primarily affects the lower limb muscles and contributes to gait impairment, COPD is also associated with an increasing risk of falls in patients (COPDp). Previous studies have reported higher rates of falls among COPDp (1.17 to 1.20 falls/person-year), amounting to four times higher than an age-matched healthy group. Potential fall risk factors include muscle weakness, impaired daily activities, cognitive dysfunction, and gait and balance impairment. Although COPDp often manifest many of these risk factors, there remains a gap in literature regarding falls during walking in this population. This study aimed to 1. analyze the literature to identify the risk factors of falling in COPDp, and 2. investigate the underlying mechanisms by which these risk factors can lead to increased prevalence of falling. The results suggest that in addition to the known risk factors of falling, low back pain and mental fatigue should also be considered as relevant risk factors in the treatment process of these patients. Moreover, respiratory problems, which are common in this population, have demonstrated pronounced effects on energy expenditure, gait, and other types of activities of daily living (ADLs), leading to reduced intensity, disrupted coordination of the trunk-pelvic structure with the lower limbs during gait, and altered motor control performance due to activation of muscles in an inefficient synergic manner. These problems potentially lead to the increased vulnerability of these patients to external disturbances and higher incidence risk of falls and injuries. Cognitive problems, which are typically due to reduced oxygen received by the brain, as well as general inflammation caused by COPD, also play a significant role in gait disruption and balance. Future research is warranted to determine the prevalence of falls in COPDp by examining the response of these patients to Medio-Lateral (ML) and Anterior-Posterior (AP) disturbances during gait in association with traditional and recommended fall risk factors.

Preprint ARTICLE | doi:10.20944/preprints202206.0230.v1

How the First Year of the COVID-19 Pandemic Impacted Patients’ Care in the Vascular Surgery Divisions of the Southern Regions of the Italian Peninsula

Eugenio Martelli, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Sangiorgi, Matilde Zamboni, Allegra Rosa Martelli, Giancarlo Accarino, Giuseppe Bianco, Francesco Bonanno, Umberto Marcello Bracale, Enrico Cappello, Giovanni Cioffi, Giovanni Colacchio, Adolfo Crinisio, Salvatore De Vivo, Carlo Patrizio Dionisi, Loris Flora, Giovanni Impedovo, Francesco Intrieri, Luca Iorio, Gabriele Maritati, Piero Modugno, Mario Monaco, Giuseppe Natalicchio, Vincenzo Palazzo, Fernando Petrosino, Francesco Pompeo, Raffaele Pulli, Davide Razzano, Maurizio Ruggero Ruggieri, Carlo Ruotolo, Paolo Sangiuolo, Gennaro Vigliotti, Pietro Volpe, Antonella Biello, Pietro Boggia, Michelangelo Boschetti, Enrico Maria Centritto, Flavia Condò, Lucia Cucciolillo, Amodio Salvatore D'Amodio, Mario De Laurentis, Claudio Desantis, Daniela Di Lella, Giovanni Di Nardo, Angelo Disabato, Ilaria Ficarelli, Angelo Gasparre, Antonio Nicola Giordano, Alessandro Luongo, Mafalda Massara, Vincenzo Molinari, Andrea Padricelli, Marco Panagrosso, Anna Petrone, Serena Pisanello, Roberto Prunella, Michele Tedesco, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: COVID-19; carotid stenosis; abdominal aortic aneurysm; chronic limb-threatening ischemia; amputation; deep venous thrombosis

Online: 16 June 2022 (04:40:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202107.0602.v1

Epigenetic Alterations in Pediatric Sleep Apnea

Emily Catherine Cheung, Matthew Wyatt Kay, Kathryn Jaques Schunke

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: epigenetic mechanisms of disease; fetal programming; obstructive sleep apnea; DNA methylation; histone modifications; chronic disease

Online: 27 July 2021 (11:45:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0569.v1

Effects of Clinical Characteristics on Sleep Quality in Patients with Chronic Temporomandibular Disorders

Yeon-Hee Lee, Q-Schick Auh, Jung-Sub An, Tae Kim

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Sleep quality; Chronic pain; Temporomandibular disorder; Pittsburgh Sleep Quality Index; STOP-Bang; Epworth Sleepiness Scale

Online: 23 June 2021 (11:11:14 CEST)

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Objectives: This study aimed to investigate and compare sleep quality between patients with chronic temporomandibular disorder and healthy controls, and to analyze the association of sleep quality with disease characteristics, obstructive sleep apnea risk factors, and excessive daytime sleepiness. Methods: Chronic temporomandibular disorder patients (n=503) and 180 age- and sex-matched healthy controls were included, who completed well-organized clinical report and answered questions on sleep quality (Pittsburgh Sleep Quality Index), sleep apnea risk factors (STOP-Bang questionnaire), and excessive daytime sleepiness (Epworth sleepiness scale). Results: Mean global Pittsburgh Sleep Quality Index scores were significantly higher in the patients (6.25±2.77) than in healthy controls (6.25±2.77) (p<0.001). Poor sleep was significantly more prevalent in the patient group (56.9%) than in healthy controls (22.2%) (p<0.001). Compared with healthy controls, chronic temporomandibular disorder patients had a higher likelihood of obstructive sleep apnea. (STOP-Bang total score ≥3; 7.2% vs. 16.1%; p<0.01) and higher excessive daytime sleepiness (Epworth sleepiness scale score ≥10; 12.8% vs. 19.7%; p<0.05). Age (odds ratio=2.551; p<0.001), female sex (odds ratio=1.885; p=0.007), total Epworth sleepiness scale score (odds ratio=1.839; p=0.014), and headache attributed to temporomandibular disorder (odds ratio=1.519; p=0.049) were the most powerful predictors of poor sleep (global Pittsburgh Sleep Quality Index score ≥5) in chronic temporomandibular disorder patients. Conclusion: Chronic temporomandibular disorder patients had sleep quality impairment. Various factors, including peripheral and central factors, affect the patient's sleep quality. Therefore, in addition to sleep quality and sleep-related problems, the underlying central mechanism for poor sleep quality should be assessed when treating chronic temporomandibular disorder patients.

Preprint ARTICLE | doi:10.20944/preprints202106.0558.v1

High Vegetables Intake and Response to COPD Rehabilitation. The Role of Oxidative Stress, Inflammation and Dna Damage.

Sara Ilari, Laura Vitiello, Patrizia Russo, Stefania Proietti, Mirta Milic, Carolina Muscoli, Vittorio Cardaci, Carlo Tomino, Gaia Bonassi, Stefano Bonassi

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Chronic obstructive pulmonary disease (COPD); Pulmonary Rehabilitation; Vegetables; DNA damage; Genomic Instability; Oxidative stress; Inflammation.

Online: 23 June 2021 (10:08:20 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202106.0263.v3

Discharge Plan to Promote Patient Safety and Shared Decision by a Multidisciplinary Team of Healthcare Professionals in a Respiratory Unit

Daniel A. Nnate, David Barber, Ukachukwu O. Abaraogu

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: chronic obstructive; patient discharge; patient care team; personalized care; interdisciplinary health team; patient safety; pulmonary disease; pulmonary medicine

Online: 14 July 2021 (09:58:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0112.v1

High Vegetables Intake and Response to COPD Rehabilitation Treatment. The Role of Oxidative Stress, Inflammation and DNA Damage

Sara Ilari, Laura Vitiello, Patrizia Russo, Stefania Proietti, Mirta Milic, Carolina Muscoli, Vittorio Cardaci, Carlo Tomino, Gaia Bonassi, Stefano Bonassi

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Chronic obstructive pulmonary disease (COPD); Pulmonary Rehabilitation; Diet; DNA damage; Genomic Instability; Oxidative stress; Inflammation

Online: 3 June 2021 (12:21:13 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202103.0680.v1

Post–Chikungunya Virus Infection Musculoskeletal Disorders: Syndromic Sequelae after an Outbreak

Hisham A. Imad, Wasin Matsee, Sajikapon Kludkleeb, Punyisa Asawapaithulsert, Juthamas Phadungsombat, Emi E. Nakayama, Keita Suzuki, Pornsawan Leaungwutiwong, Watcharapong Piyaphanee, Weerapong Phumratanaprapin, Tatsuo Shioda

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Acute febrile illness; Alphavirus; chikungunya virus; post-chikungunya musculoskeletal disorder; post-chikungunya chronic inflammatory rheumatism

Online: 29 March 2021 (10:56:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0045.v1

Effects of Direct-Acting Antiviral Agents on the Mental Health of Patients with Chronic Hepatitis C: A Prospective Observational Study

Michele Fabrazzo, Rosa Zampino, Martina Vitrone, Gaia Sampogna, Lucia Del Gaudio, Daniela Nunziata, Salvatore Agnese, Anna Santagata, Emanuele Durante-Mangoni, Andrea Fiorillo

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Chronic hepatitis C; Direct-acting antiviral agents; Hepatitis C virus; Consultation-liaison psychiatry; Depression; Anxiety

Online: 5 July 2020 (05:15:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0029.v1

Cell-Based Blood Biomarkers for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Daniel Missailidis, Oana Sanislav, Claire Allan, Sarah Annesley, Paul Fisher

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Myalgic Encephalomyelitis; Chronic Fatigue Syndrome; mitochondria; Complex V; TORC1; Seahorse respirometry; biomarker; diagnosis; ME/CFS

Online: 3 February 2020 (10:36:05 CET)

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Preprint REVIEW | doi:10.20944/preprints201704.0171.v1

Peroxiredoxin 4 (PRDX4): Its Critical In Vivo Roles in Animal Models of Metabolic Syndrome Using Our Unique PRDX4 Transgenic Mice

Sohsuke Yamada, Xin Guo, Akihide Tanimoto

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Peroxiredoxin (PRDX) 4, chronic inflammatory disease, metabolic syndrome, human PRDX4 transgenic mice (Tg), animal model.

Online: 26 April 2017 (17:57:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0733.v1

Differential Regional Textural Attributes of Tongue in Normal and Acidity Patients in the Light of Traditional Chinese Medicine

Debasis Bakshi, Debaleena Nawn, Sujata Pal, Chandana Mitra, Maya Das, Jyotirmoy Chatterjee

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: TCM based tongue diagnosis, tongue colour, local texture, chronic acidity,
GLCM, inter and intragroup analysis.

Online: 10 July 2024 (08:05:45 CEST)

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Introduction: In Traditional Chinese Medicine (TCM), tongue diagnosis plays an important role. Besides shape, colour and textural attributes of tongue regions have significance due to their association with different organs (viz. heart, lung, kidney-bladder, liver-gallbladder and stomach-spleen) in health and disease. Although numerous quantitative methods have been proposed to reduce inter and intra observer variability in tongue diagnosis, almost all of them considered only global colour/ textural features i.e. from entire body of tongue. In this work, regional colour and texture information of tongue have been analysed for healthy subjects (NOM) and patients suffering from chronic acidity-indigestion (ACD). Methods: Tongue boundaries are marked manually in each image and then tongue bodies are automatically partitioned into five regions linked with said internal organs. Rough assessments of regions’ boundaries are obtained from literature and then they are fine-tuned according to experts’ advice. As boundaries are not well defined, regions near the common boundary of two or more organs, are not assigned to any organ. Several first and second order statistical features based on grey scale intensities and a* values of LAB colour space (indicative of redness) have been extracted from five different regions of tongue images. Intragroup analysis using Wilcoxon signed rank test compared different regions within individual study group. Additionally, intergroup analysis using Wilcoxon rank sum test compared tongues of NOM with ACD for each region separately. Results: Intragroup analysis reveals a* values are statistically different (p<0.01) between stomach-spleen and liver-gallbladder regions for ACD while no significant change of a* are noted between these regions of normal tongue. It was found from intergroup analysis that correlation (one of the second order texture features extracted from grey scale images) of heart region has significantly decreased while correlation of kidney, liver-gallbladder and stomach-spleen regions significantly increased from NOM to ACD. Conclusion: This study sheds light on importance of inclusion of regional textural analysis of tongue in quantitative studies and can be applied to automated tongue diagnosis for other diseases.

Preprint REVIEW | doi:10.20944/preprints202407.0048.v1

Cellular and Molecular Biology of Mitochondria in Chronic Obstructive Pulmonary Disease

Chin-Ling Li, Shih-Feng Liu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: chronic obstructive pulmonary disease; cellular and molecular biology of mitochondria; antioxidants and mitochondrial biogenesis; mitochondrial biomarkers

Online: 1 July 2024 (08:20:27 CEST)

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Abstract: Chronic Obstructive Pulmonary Disease (COPD) is a continually advancing respiratory disorder, characterized by enduring airflow limitation along with long-lasting inflammation in the airways. An expanding pool of evidence is emphasizing how mitochondrial dysfunction directly impacts the development and progression of COPD. This comprehensive review delves deeper into the intricate cellular and molecular biology of mitochondria within the framework of COPD, spotlighting significant alterations in structure and function that accompany mitochondrial dysfunction. In this narrative, we delve into the observed changes in mitochondrial shape, behavior, and respiratory chain complex alterations seen in individuals afflicted with COPD. The discussion includes implications on cellular signaling pathways and how this affects the natural process of programmed cellular death (apoptosis) and cellular aging, particularly in reference to COPD. Additionally, we consolidate ongoing therapeutic strategies, honing in on the management of COPD through a focus on mitochondrial dysfunction. Prominent among these strategies is the potential role of antioxidants and mitochondrial biogenesis inducers, which are emerging as promising fields of intervention. Furthermore, we embark on an overview of the possible use of mitochondrial biomarkers as innovative tools in diagnosing COPD, evaluating disease progression, and monitoring the efficacy of COPD treatments. As we unravel the rather complex interplay between mitochondrial biology and COPD, this review highlights the critical importance of formulating treatments that target mitochondrial dysfunction. The ultimate goal of these strategic interventions is to slow down the rate of COPD progression and significantly improve patient outcomes. Lastly, though our understanding of the nexus between COPD and mitochondrial dysfunction has significantly enhanced, ample scope remains for further investigation. Improved insights into the mechanisms of mitochondrial dysfunction, discovered biomarkers, and targeted therapies could encompass a revolutionary step towards comprehensive disease management. The future of COPD treatment seems to lean towards a combination of strategies, prioritizing not only the management of symptoms but also focused on preserving and restoring lung function, improving physical capacity, and enhancing quality of life for COPD patients.

Preprint REVIEW | doi:10.20944/preprints202405.0916.v1

Actional Mechanism of Functional Ingredients in Beer and Barley for Human Health

Yawen Zeng, Hafiz Ghulam Muhu-Din Ahmed, Xia Li, Li’E Yang, Xiaoying Pu, Xiaomeng Yang, Tao Yang, Jiazhen Yang

Subject: Biology And Life Sciences, Food Science And Technology Keywords: functional ingredients; actional mechanism; barley grains and grass; beer; malt; hops; functional foods; chronic diseases; human

Online: 14 May 2024 (06:50:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.0765.v1

The Contribution of Tumor Necrosis Factor to Multiple Sclerosis Progression Independent of Relapses

Valentina Mazziotti, Francesco Crescenzo, Ermanna Turano, Maddalena Guandalini, Maddalena Bertolazzo, Stefano Ziccardi, Federica Virla, Valentina Camera, Damiano Marastoni, Agnese Tamanti, Massimiliano Calabrese

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: TNF biology; MS pathology; PIRA; MS lesions; chronic compartmentalized inflammation; neurodegeneration; biomarkers; disease progression. 1. Introduction

Online: 10 January 2024 (09:54:47 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0047.v1

Edible Insects as a Source of Dietary Protein for Companion Animals – Perspectives and Possibilities

Remigiusz Gałęcki, Maria Hanuszewska-Dominiak, Ewa Kaczmar

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: veterinary diets; edible insects; veterinary medicine; edible insect industry; food-responsive enteropathies (FRE); chronic enteropathies (CE)

Online: 2 January 2024 (07:53:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1957.v1

A Single-Session Process-Based Cognitive-Behavioural Interven-Tion for Chronic Pain Associated with Emotional Disorders

Cristiana Manuela Cojocaru, Cosmin Octavian Popa, Alina Schenk, Zsolt Jakab, Bogdan Andrei Suciu, Peter Olah, Horațiu Valeriu Popoviciu, Simona Szasz

Subject: Social Sciences, Psychiatry And Mental Health Keywords: rheumatic conditions; chronic pain; anxiety; depression; psychological intervention; process-based cognitive-behavioural therapy; single-session intervention

Online: 28 December 2023 (02:23:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1566.v1

Modulation of miR-29a and miR-29b Expression by an Oral Nutritional Supplement Similar to the Mediterranean Diet Pattern with Probiotics in Malnourished Hemodialysis Patients

Corina Verónica Sasso, Said Lhamyani, Francisco Hevilla, Marina Padial, María Blanca, Guillermina Barril, Tamara Jiménez-Salcedo, Enrique Sanz Martínez, Ángel Nogueira, Ana María Lago-Sampedro, Gabriel Olveira

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: chronic kidney disease; oral nutritional supplement; malnutrition; hemodialysis; probiotics; circulating miRNAs; gene expression; inflammation; renal fibrosis

Online: 20 December 2023 (13:46:40 CET)

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Malnutrition is prevalent in patients with chronic kidney disease (CKD), especially those on hemodialysis. Recently, our group described that a new oral nutritional supplement (ONS) for malnourished (or at-risk) hemodialysis patients with a "similar to the Mediterranean diet" model, improved caloric and protein intake, nutritional status and inflammation and oxidation biomarkers. Our aim in this study was to evaluate whether the new ONS, including probiotics, may produce changes in miRNAs expression and its target genes in malnourished hemodialysis patients, compared to individualized diet recommendations. We conducted a randomized, multicenter, parallel-group study in malnourished hemodialysis patients divided in 3 groups (1: Control -C- individualized diet 2: Oral nutritional supplement -ONS- + placebo -ONS-PL- and 3: ONS + probiotics -ONS-PR). Study registration: NCT03924089. The trial was open to the ONS diet or individual dietary advice, but double-blind for the intake of probiotics supplements. MiRNAs and gene expression levels were analyzed by RT-qPCR at baseline and after 3 and 6 months. We observed that the expression of miR-29a and miR-29b increased significantly in patients with ONS-PR at 3 months in comparison with baseline, stabilizing at the sixth month. Moreover, we observed differences between studied groups, where miR-29b expression levels were elevated in patients receiving ONS-PR compared to the control group in the third month. Regarding the gene expression levels, we observed a decrease in the ONS-PR group compared to the control group in the third month for RUNX2 and TNFα. TGFB1 expression was decreased in the ONS-PR group compared to baseline in the third month. PTEN gene expression was significantly elevated in the ONS-PR group at 3-months in comparison with baseline. LEPTIN expression was significantly increased in ONS-PL group at 3-month intervention compared to baseline. The new Oral Nutritional Supplement associated with probiotics; increases the expression levels of miR-29a and miR-29b after 3 months of intervention, modifying the expression of target genes with anti-inflammatory and anti-fibrotic actions. This study highlights the potential benefit of this Oral Nutritional Supplement, especially associated with probiotics, in malnourished patients with chronic renal disease on hemodialysis.

Preprint ARTICLE | doi:10.20944/preprints202312.0161.v1

Haemolytic Anaemia-Related Pulmonary Hypertension

Panagiotis K Karyofyllis, Eftychia A Demerouti, Eleftheria-Garyfallia N Tsetika, Styliani G Apostolopoulou, Panagiotis D Tsiapras, Ioannis Iakovou, Dimitrios P Tsiapras

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Pulmonary Hypertension; Haemolytic anemia; Haematological Disorders; Chronic Thromboembolic Pulmonary Hypertension; Pulmonary Arterial Hypertension; Balloon Pulmonary Angioplasty

Online: 5 December 2023 (06:18:52 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.1554.v1

Mitochondrial Dysfunction and Coenzyme Q10 Supplementation in Post-Viral Fatigue Syndrome: An Overview

David Mantle, Iain Parry Hargreaves, Joan Carles Domingo, Jesus Castro-Marrero

Subject: Biology And Life Sciences, Life Sciences Keywords: chronic fatigue syndrome; coenzyme Q10; fibromyalgia; Long COVID; mitochondrial dysfunction; myalgic encephalomyelitis; post-viral fatigue syndrome

Online: 24 November 2023 (11:27:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0401.v1

Influence of Comorbidities on Chronic Obstructive Pulmonary Disease (COPD) Outcomes: Risk Prediction of Acute Exacerbations Using the Cumulative Illness Rating Scale (Cirs)

Domenico Di Raimondo, Edoardo Pirera, Chiara Pintus, Riccardo De Rosa, Martina Profita, Gaia Musiari, Gherardo Siscaro, Antonino Tuttolomondo

Subject: Biology And Life Sciences, Aging Keywords: Comorbidity; Multimorbidity; Chronic Obstructive Pulmonary Disease; COPD; Cumulative Illness Rating Scale; acute exacerbation of COPD (AECOPD)

Online: 7 November 2023 (10:33:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1984.v1

Urinary L-FABP, a Biomarker for Disease Progression, Dialysis and Overall Mortality in Chronic Kidney Disease

Nicos Mitsides, Vikram Mitra, Ananya Saha, Shelley Harris, Philip A. Kalra, Sandip Mitra

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: chronic kidney disease; biomarkers; urinary liver type fatty acid binding protein; urinary protein to creatinine ratio

Online: 28 September 2023 (10:17:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1021.v1

Precise Filtration of Chronic Myeloid Leukemia Cells by an Ultrathin Microporous Membrane with Backflushing to Minimize Fouling

Jaehyuk Lee, Jeongpyo Hong, Jungwon Lee, Changgyu Lee, Tony Kim, Young Jeong, Kwanghee Kim, Inhwa Jung

Subject: Engineering, Bioengineering Keywords: ultra-thin porous membrane; pumping head for backflush; chronic myeloid leukemia cell; fouling; blocking filtration model

Online: 14 July 2023 (15:23:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.2257.v1

Different Antihypertensive and Metabolic Responses to Rostafuroxin in Undernourished and Normonourished Male Rats: Outcomes on Bodily Na⁺ Handling

Amaury Pereira-Acácio, João Veloso-Santos, Danilo Alves Bezerra, Glória Costa-Sarmento, Humberto Muzi-Filho, Adalberto Vieyra

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: rostafuroxin; arterial hypertension; chronic undernutrition; Regional Basic Diet; sodium and water balance; renal Na+-transporting ATPases

Online: 30 June 2023 (14:51:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0456.v1

Hepatitis E Virus Infections

Busara Songtanin, Adebayo J. Molehin, Kevin Brittan, Wuttiporn Manatsathit, Kenneth Nugent

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: hepatitis e virus; hepatitis e infection; immunocompromised host; organ transplantation; extrahepatic manifestation; chronic hepatitis E; hepatology

Online: 6 June 2023 (11:53:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1254.v1

The Association of Oxidative Stress-Related Gene Polymorphisms with Pain-Related Temporomandibular Disorders and Oral Behavioural Habits

Ema Vrbanović, Marko Zlendić, Koraljka Gall Trošelj, Marko Tomljanović, Kristina Vuković Đerfi, Iva Zilic-Alajbeg

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: antioxidants; chronic orofacial pain; oxidative-stress related genes; temporomandibular disorders; oral behavioural habits; single nucleotide polymorphism

Online: 17 May 2023 (14:15:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1242.v1

Undernutrition Modifies the Antihypertensive and Metabolic Responses of Rostafuroxin in Male Rats: Outcomes on Bodily Na⁺ Handling and Renal Na⁺-transporting ATPases

Amaury Pereira-Acácio, João P.M. Veloso-Santos, João P.M. Veloso-Santos, Glória Costa-Sarmento, Humberto Muzi-Filho, Adalberto Vieyra

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: rostafuroxin; arterial hypertension; chronic undernutrition; Regional Basic Diet; sodium and water balance; renal Na+-transporting ATPases

Online: 17 May 2023 (10:58:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0078.v1

Personalizing Digital Health: Adapting Health Technology Systems to Meet the Needs of Different Older Populations

Jennifer Jimenez, Alberto del Rio, Arianna N. Berman, Miriam Grande

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: aging population; healthcare systems; healthcare system evaluation; chronic illness; digital healthcare; personalization; healthcare usability; healthcare satisfaction

Online: 6 April 2023 (08:48:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0071.v1

Lysophospholipids, Lysophosphatidic Acids and Monoacylglycerols: New Therapeutic Targets in Cardiovascular Diseases?

Thomas Duflot, Ly Tu, Matthieu Leuillier, Hind Messaoudi, Déborah Groussard, Saïda Azhar, Raphaël Thuillet, Marc Humbert, Vincent Richard, Christophe Guignabert, Jérémy Bellien

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: lysophospholipids; lysophosphatidic acids; cardiovascular diseases; HPLC-MS/MS; rodent models; pulmonary hypertension; chronic heart failure; hypertension

Online: 3 September 2021 (15:19:54 CEST)

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Working Paper COMMUNICATION

Pressure Point Threshold Scores and ME/CFS Comorbidity as Indicators of Patient´s Response to Manual Physiotherapy in Fibromyalgia

Francisco Javier Falaguera-Vera, María Garcia-Escudero, Javier Bonastre-Férez, Mario Zacarés, Elisa Oltra

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Fibromyalgia; Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS); Pressure Point Threshold (PPT); Physiotherapy; Manual Therapy (MT)

Online: 15 September 2020 (09:01:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202002.0342.v1

Regulation of the Proteolytic Activity of Cysteine Cathepsins by Oxidants

Gilles Lalmanach, Ahlame Saidi, Paul Bigot, Thibault Chazeirat, Fabien Lecaille, Mylène Wartenberg

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cathepsin; chronic obstructive pulmonary disease (COPD); cigarette smoke; cysteine; cysteine protease; emphysema; oxidation; proteolysis; ROS; thiol

Online: 24 February 2020 (02:48:00 CET)

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Preprint REVIEW | doi:10.20944/preprints201907.0196.v1

Pathological Mechanisms Underlying Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Daniel Missailidis, Sarah Annesley, Paul Fisher

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Myalgic Encephalomyelitis, Chronic Fatigue Syndrome, ME/CFS, diagnosis, metabolism, mitochondria, inflammation, immune system, signaling, gut microbiota.

Online: 16 July 2019 (12:41:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.2324.v1

Choroidal Response to Intravitreal Bevacizumab Injections in Treatment-Naïve Macular Neovascularization Secondary to Chronic Central Serous Chorioretinopathy

David Rabinovitch, Shiri Shulman, Dafna Goldenberg, Liang Wang, Prashanth Iyer, Anat Loewenstein, Noah Igra, Olivia Levine, Gissel Herrera, Omer Trivizki

Subject: Medicine And Pharmacology, Ophthalmology Keywords: Chronic Central Serous Chorioretinopathy; Anti-VEGF; Macular Neovascularization; Optical Coherence Tomography Angiography (OCTA); Choroidal thickness; Subretinal fluid

Online: 30 October 2024 (06:52:12 CET)

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Preprint REVIEW | doi:10.20944/preprints202410.0974.v1

Genetic Mechanisms of Natural Short Sleep: A Review of DEC2, ADRB1, NPSR1, GRM1 Mutations and Recommended Testing for Chronic Health Implications

Helene Gu

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Familial Natural Short Sleep; Sleep Genetics; Sleep Medicine; Chronic Sleep Deprivation; ADRB1; DEC2; GRM1; NPSR1

Online: 15 October 2024 (03:32:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1785.v1

Physical Health and Welfare States of Fin (Balaenoptera physalus) and Humpback Whales (Megaptera novangliae) in an Anthropized Environment: Validation of a First Animal-Based Welfare Assessment Protocol for Wild Cetaceans

Anik Boileau, Jonathan Blais, Marie-Francoise Van Bressem, Kathleen Ellen Hunt, Jamie Ahloy-Dallaire

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Humpback Whales; Fin Whales; Welfare Assessment; Anthropized environment; Chronic Stress; Entanglement; Physical health; Body condition; Cutaneous lesions

Online: 24 September 2024 (11:32:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1274.v1

Immunogenicity and Safety of the Recombinant Adjuvanted Herpes Zoster Vaccine in Patients with Chronic Lymphocytic Leukemia and Multiple Myeloma

Panagiotis T. Diamantopoulos, Christos Stafylidis, Vassiliki Labropoulou, Christina-Nefeli Kontandreopoulou, Dimitra Vlachopoulou, Stavroula Smilakou, Iraklis Patsialos, Stavroula Syriopoulou, Alexandros Gkikas, Eleftherios N Athanasopoulos, Anastasios Vogiatzakis, Eleni Panousi, Georgios Kyriakakis, Amalia Anastasopoulou, Marina Mantzourani

Subject: Medicine And Pharmacology, Hematology Keywords: Varicella-zoster virus (VZV); chronic lymphocytic leukemia; multiple myeloma; recombinant adjuvanted herpes zoster vaccine (RZV); immunogenicity; safety

Online: 17 September 2024 (03:34:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0496.v1

Exploring the Role of Psychedelic Experiences on Wellbeing and Symptoms of Disordered Eating

Nadine Loh, David Luke

Subject: Social Sciences, Psychiatry And Mental Health Keywords: Psychedelics; eating disorders; anorexia; chronic; qualitative; mystical experience; psilocybin; ayahuasca; psychedelic experience; psychedelic assisted therapy; treatment resistant

Online: 6 September 2024 (09:38:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.2081.v1

Prevalence, Characteristics, and Awareness of Chronic Kidney Disease in Croatia. The EH-UH 2 Study

Ana Jelaković, Danilo Radunović, Josipa Josipović, Tajana Željković Vrkić, Lana Gellineo, Marija Domislović, Vladimir Prelević, Marijana Živko, Mirjana Fuček, Mihaela Marinović Glavić, Nikolina Bašić‐Jukić, Ivan Pećin, Marija Bubaš, Krunoslav Capak, Bojan Jelaković

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: albuminuria; awareness; chronic kidney disease; cardiovascular risk; eGFR (CKD Epi) formula; glomerular filtration rate; national population survey

Online: 28 August 2024 (14:45:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.0286.v1

Decoding LncRNA in COPD: Unveiling Prognostic and Diagnostic Power and Their Driving Role in Lung Cancer Progressions

Osama Sweef, Reda Mahfouz, Tülin Taşcıoğlu, Ali Albowaidy, Mohamed Abdelmonem, Malek Asfar, Elsayed Zaabout, Yalitza Lopez Corcino, Venetia Thomas, Eun-Seok Choi, Saori Furuta

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Chronic Obstructive Pulmonary Disease (COPD); Long Non-Coding RNAs (lncRNAs); Molecular Pathogenesis; Inflammation; Lung Cancer; Diagnostic Biomarkers

Online: 3 July 2024 (16:16:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0092.v1

Dispensing Error Rate in an App-Based, Semaglutide-Supported Weight-Loss Service: A Retrospective Case Study

Louis Talay, Matt Vickers

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Dispensing errors; GLP-1 RA medications; Digital pharmacy; Obesity; Chronic care; Multidisciplinary care; Third party pharmacy; Telehealth

Online: 1 July 2024 (11:49:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.1292.v1

Mitigating Endemic COVID-19 Risks in Patients with Chronic Kidney Disease and Kidney Transplantation: A Narrative Review

Behram Ali Khan, Kajohnsak Noppakun, Jackrapong Bruminhent, Sunate Chuenkitmongkol, Zainab Habibullah, Sasisopin Kiertiburanakul, Iris Rengganis, Boon Wee Teo

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: COVID-19; Omicron; chronic kidney disease (CKD); end-stage kidney disease (ESKD); dialysis; kidney transplantation; immunocompromised; immunosuppressed

Online: 20 May 2024 (17:01:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1756.v1

Designing Nerve Growth Factor Analogues to Suppress Pain Signal Transduction Mediated by the p75NTR-NGF-TrkA Complex: A Structural and Biophysical Perspective

Wei Li

Subject: Biology And Life Sciences, Biophysics Keywords: Nerve growth factor (NGF); NGF analogues; anti-NGF antibodies; chronic pain signal transduction; p75NTR-NGF-TrkA complex

Online: 28 March 2024 (13:39:38 CET)

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As a key mediator of chronic pain, neurotrophin nerve growth factor (NGF) binds to two neurotrophin receptors: p75 neurotrophin receptor (p75NTR) and tyrosine kinase receptor A (TrkA). The formation of the p75NTR-NGF-TrkA complex is implicated in the potentiation of chronic pain signals, making it an attractive target for therapeutic explorations. NGF analogues and monoclonal antibodies (mAbs) targeting NGF represent two distinct approaches in modulating the intricate signaling pathways involved in pain transduction mediated by the p75NTR-NGF-TrkA complex. While NGF analogues offer the advantage of tailored design to fine-tune neurotrophic responses, monoclonal antibodies provide a more systemic and comprehensive blockade of NGF, inhibiting its interactions with both p75NTR and TrkA receptors. However, the use of mAbs may pose challenges related to potential side effects and interference with the physiological functions of NGF. As a result, balancing the benefits and drawbacks of the two approaches is critical for advancing therapeutic strategies towards the alleviation of p75NTR-NGF-TrkA-mediated pain. In this study, therefore, a novel structural and biophysical approach was employed for the design of NGF analogues to suppress p75NTR-NGF-TrkA-related chronic pain signaling. Employing high-throughput structural modeling and biophysics-based intermolecular binding affinity calculations, this article for the first time puts forward a set of NGF analogues, including in particular NGF analogues with four site-specific mutations, for whose dimerizations the K d at 37 ^◦C were reduced by three orders of magnitude (from 10^-9 M to 10^-6 M) compared to the K d at 37 ^◦C for the dimerization of native NGFs. Overall, the integration of structural and biophysical perspectives enhances our understanding of the rational design of NGF analogues as promising candidates for the development of NGF-targeted analgesic therapies, which balances the benefits and drawbacks of anti-NGF antibodies and NGF analogues for advancing therapeutic strategies towards the alleviation of p75NTR-NGF-TrkA-mediated pain.

Preprint ARTICLE | doi:10.20944/preprints202402.0749.v1

Unveiling the Landscape of COVID-19 Vaccination in Saudi Arabia: A Socio-Demographic, Clinical, and Vaccine Profile Analysis

Gehad Subaiea, Nawaf Alkhateeb, Faisal Sahman, Abdulrahman Alsudayri, Abdulkarim Mohammed Almudayni, Hamoud Alrashidi, Abdulrahman Majid Alshammari, Ahmed Alsolami, Abdulmalik M. Alqarni, Abdulwahab Alamri, Yasser Alhabeeb, Sirajudheen Anwar

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: COVID-19 vaccination; Saudi Arabia; Cross-sectional study; Socio-demographic characteristics; Chronic conditions; Vaccine administration; Infection rates

Online: 13 February 2024 (12:40:53 CET)

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The worldwide competition to vaccinate against COVID-19 has highlighted the importance of immunization measures in containing the virus. Saudi Arabia, like the rest of the globe, must assess socio-demographic subtleties, chronic illnesses, vaccination effects, and public health policy implications as it navigates this complicated environment. This cross-sectional study examined Saudi COVID-19 vaccine in many ways. It examined the socio-demographic makeup of vaccine recipients, the prevalence of chronic conditions in this population, vaccine administration patterns, post-vaccination side effects, and vaccine-infection rates. A questionnaire-based online survey of 401 participants ensured gender, nationality, age, weight, and educational diversity. We analyzed vaccine manufacturer choice for each dosage, side effects after the first and second doses, and chronic diseases in the sample. Pfizer/BioNTech vaccines are preferred for all three doses, reflecting worldwide vaccination acceptance patterns. Side effects were not significantly different between vaccination kinds. Interestingly, immunization reduced infection rates, demonstrating the efficacy of COVID-19 vaccines. The data fills important information gaps and illuminates Saudi COVID-19 vaccination kinetics. These data support the global preference for mRNA vaccines, demonstrating the faith in this breakthrough technology. They also sponsor COVID-19 vaccine safety and effectiveness studies. The dramatic drop in infection rates among vaccinated people shows how vaccinations suppress the pandemic. These findings inform Saudi Arabia's immunization efforts. As booster doses become more common, long-term vaccination research is crucial. Vaccine reluctance, especially in certain demographics, must be addressed. Due to vaccines' protective potential, equitable vaccine distribution and large immunization programs are essential for herd immunity and pandemic management. This thorough cross-sectional study helps policymakers and healthcare practitioners build successful and inclusive COVID-19 immunization regimens in Saudi Arabia.

Preprint REVIEW | doi:10.20944/preprints202401.1747.v1

Chronic Lymphocytic Leukemia: Prognostic/Predictive Factors in the Era of Novel Drugs

Antonio Urso, Enrica Antonia Martino, Antonio Cuneo, Massimo Gentile, Gian Matteo Rigolin

Subject: Medicine And Pharmacology, Hematology Keywords: chronic lymphocytic leukemia; BTK inhibitors; BCL-2 inhibitors; prognostic scores; predictive factors; TP53 abnormalities; IGHV; complex karyotype

Online: 24 January 2024 (13:39:51 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1535.v2

Polymer Delivery Systems for Long-Acting Antiretroviral Drugs

Mohammad Ullah Nayan, Sudipta Panja, Ashrafi Sultana, Lubaba A. Zaman, Lalitkumar K. Vora, Brady J. Sillman, Howard E. Gendelman, Benson Edagwa

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: long-acting formulations; polymer; antiretroviral therapy; HIV; chronic infectious diseases; implants; vaginal rings; prodrug nanoformulations; microarray patches

Online: 24 January 2024 (05:48:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1159.v1

Balázs Sági, Tibor Vas, Botond Csiky, Judit Nagy, Tibor József Kovács

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Platelet-to-albumin ratio, Platelet-to-lymphocyte ratio, Chronic kidney disease, IgA nephropathy, Renal and cardiovascular prognosis.

Online: 16 January 2024 (08:51:08 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.1841.v1

A Possible Therapeutic Application of The Selective Inhibitor of Urate Transporter 1, Dotinurad, for Metabolic Syndrome, Chronic Kidney Disease, and Cardiovascular Disease: A Significance of Inhibition of Urate Transporter 1 and Non-inhibition of Other Urate Transporters for Such Diseases

Hidekatsu Yanai, Hiroki Adachi, Mariko Hakoshima, Sakura Iida, Hisayuki Katsuyama

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: ATP-binding cassette transporter G2; chronic kidney disease; dotinurad; hyperuricemia; organic anion transporter1/3; urate transporter 1

Online: 26 December 2023 (03:03:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0967.v1

Ecological Sorrow: Types of Grief and Loss in Ecological Grief

Panu Pihkala

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: climate grief; solastalgia; bereavement; eco-anxiety; chronic sorrow; nonfinite loss; sadness; disenfranchised grief; anticipatory mourning; ambiguous loss

Online: 15 November 2023 (16:34:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1793.v1

The Antidepressant Activity Taurine Containing Derivative of 4-Phenylpyrrolidone-2 in a Model of Chronic Unpredictable Mild Stress

Denis A Borozdenko, Darya I. Gonchar, Vlada I. Bogorodova, Dmitri V. Tarasenko, Eugene P Kramarova, Svetlana S. Khovanova, Yaroslav V. Golubev, Nina M. Kiseleva, Tatiana Anatolievna Shmigol, Aiarpi A. Ezdoglian, Konstantin A. Sobyanin, Vadim V. Negrebetsky, Yuri. I. Baukov

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: fluoxetine 1; antidepressant activity 2; chronic unpredictable mild stress 3; 4-phenylpyrrolidinone-2 derivative 4; hormones 5

Online: 27 October 2023 (12:53:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0551.v1

Chronic Kidney Disease in the Elderly Patient with Diabetes

Raja Ravender, Maria-Eleni Roumelioti, Darren W Schmidt, Mark L Unruh, Christos Argyropoulos

Subject: Medicine And Pharmacology, Other Keywords: Diabetes; Chronic Kidney Disease; Treatment; Elderly; Geriatric; Dialysis; SGLT2 inhibitors; GLP1 Receptor Agonists; Non-steroidal Mineralocorticoid Antagonists

Online: 9 October 2023 (16:56:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1417.v1

Mice Overexpressing Wild Type RRAS2: A Novel Preclinical Model for Testing Anti-Chronic Lymphocytic Leukemia Therapies

Balbino Alarcón, Alejandro M. Hortal, Ana Villanueva, Irene Arellano, Cristina Prieto, Pilar Mendoza, Xose R Bustelo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: R-RAS2; RAS; GTPases; chronic lymphocytic leukemia; B-CLL; mouse model; ibrutinib; venetoclax; new therapies; cancer treatment

Online: 21 September 2023 (12:04:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0867.v1

Sex Differences In Glomerular Lesions, Atherosclerosis Progression, And In The Response To Angiotensin-Converting Enzyme Inhibitors In The Apoe^-/- Mice Model

Adrián Mallén, Ronny Rodriguez-Urquia, Rafael Alvarez, Eduard Dorca-Duch, Estanis Navarro, Miguel Hueso

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Sex differences; Chronic Kidney Disease; Atherosclerosis; Foam Cells; Parietal Epithelial Cells (PECs); Angiotensin-Converting Enzyme Inhibitors (ACEi)

Online: 13 June 2023 (03:22:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0559.v1

Cartilage Conduction Hearing Aids in Clinical Practice

Tadashi Nishimura, Hiroshi Hosoi, Ryota Shimokura, Tadashi Kitahara

Subject: Medicine And Pharmacology, Otolaryngology Keywords: Bone conduction; Cartilage conduction; Hearing device; Amplification; Aural atresia; Canal stenosis; Conductive hearing loss; Chronic otitis media

Online: 7 June 2023 (13:22:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1671.v1

Comparison of Portable Oxygen Concentrators and Inspired Oxygen Levels Using a COPD Patient Simulation Model

Douglas S. S Gardenhire, Robert B Murray, Robin E Gardenhire, Kyle Brandenberger

Subject: Public Health And Healthcare, Other Keywords: portable oxygen concentrators; chronic obstructive pulmonary disease; home oxygen therapy; respiratory care; oxygen therapy; obstructive lung disease

Online: 24 May 2023 (02:44:53 CEST)

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Background: Portable oxygen concentrators (POCs) have shown efficacy in delivering adequate oxygen for various patient scenarios; however, there is a lack of research on POCs’ efficacy across different respiratory rates specifically among COPD patients. Methods: This bench study was conducted using the IngMar Medical Active Servo Lung 5000 attached to flexible tubing, which simulated an adult patient’s nares. An oxygen analyzer (Maxtec Handi+) was connected to the tubing 6 inches below the nares to estimate the inspired oxygen concentration at the adult trachea. A standard nasal cannula was placed in the simulated patient nares, which was also attached to each POC. The IngMar Lung was programmed to simulate a COPD patient at the following respiratory rates: 15, 20, 30, and 40 breaths/min. POC devices were then compared to an oxygen wall outlet and a standard oxygen concentrator (non-portable CAIRE device). The POCs included the CAIRE FreeStyle Comfort (with Autosat), CAIRE FreeStyle Comfort (without Autosat), Inogen G4, Inogen G5, Phillips SimplyGo Mini, GCE Zen-O lite, Drive Medical iGo2, and Kingon POCs. Descriptive statistics and ANOVAs were computed to determine statistically significant differences between POCS and control devices (wall oxygen and standalone oxygen concentrator). Results: Across most respiratory rate scenarios, the wall oxygen and standalone oxygen concentrator (control group) resulted higher oxygen measurements compared to the POCs. Among the POCs on setting 2, the highest oxygen measurement for 15, 30, and 40 breaths/min was the CAIRE FreeStyle Comfort with AutoSat on sensitivity 5 (24.43%, 24.81%, and 25.0%, respectively). On setting 2, the 20 breaths/min highest oxygen measurement was the Inogen G4 (24.43%). For setting 5, the highest oxygen measurement for 15 breaths/min and 40 breaths/min was the CAIRE FreeStyle Comfort without AutoSat (31.56% and 26.13%, respectively), while the highest oxygen measurement for 20 breaths/min was the Inogen G5 (30.26%), and the highest oxygen measurement for 30 breaths/min was the CAIRE FreeStyle Comfort with AutoSat on sensitivity level 5 (27.89%). Conclusions: The oxygen administered through the wall and the standalone CAIRE oxygen concentrator all delivered higher oxygen levels compared to the POCs (with the exception of the 40 breaths/min scenario on setting 2). However, among the POCs, the CAIRE Freestyle Comfort with AutoSat, CAIRE Freestyle Comfort without AutoSat, and the Inogen G4 all performed the best among the various breathing rate scenarios.

Preprint ARTICLE | doi:10.20944/preprints202303.0212.v1

An Audit of Geriatric Capacity Assessments Performed in a General Psychiatry Unit over a Decade

Eduard P. Drima MD

Subject: Social Sciences, Psychology Keywords: Geriatric decisional capacity assessment; wealth transfer; mild cognitive impairment; mild depression; neutrophils to lymphocytes ratio; chronic inflammation

Online: 13 March 2023 (04:10:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202208.0292.v1

Study the Correlation between the Mother-To-Child Transmission Risk Factors in Chronic Hepatitis B Virus Infection Pregnant Women in Vietnam by HCA Method

Tram Thi Ngoc Hoang, Thi Thu Huong Bui, Thi Thuy Pham, Thi Lan Anh Luong, Thi Kim Phuong Doan, Thu Lan Hoang, Cam Tu Ho, Nina Koerber, Khanh Lam Ho, Duc Hinh Nguyen, Tanja Bauer, Ulrike Protzer, Tien Dung Nguyen

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Chronic Hepatitis B Virus Infection; Liver; Pregnant Women; Cord blood; PBMCs (Peripheral Blood Mononuclear Cells); subclinical index

Online: 16 August 2022 (14:17:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0478.v1

You + ME Registry: A Research Platform to Facilitate Clinical and Therapeutic Discoveries in ME/CFS and Related Diseases

Allison Ramiller, Kathleen Mudie, Elle Seibert, Sadie Whittaker

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome; Long COVID; data acquisition source; post-infectious; longitudinal cohort study; patient-powered

Online: 25 November 2021 (13:51:54 CET)

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Preprint REVIEW | doi:10.20944/preprints202110.0233.v1

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

Rodney R. Dietert

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: microbiome; public health; chronic diseases; microimmunosome; eating disorders; subtance use disorder; commensals; pathobionts; sensory receptors; developmental programming

Online: 15 October 2021 (16:57:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0176.v1

Strategies to Inhibit Hepatitis B Virus Gene Transcription

Bingqian Qu, Richard J. P. Brown

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: chronic hepatitis B; covalently closed circular DNA; viral integration; transcription factor; nuclear receptor; transcriptional inhibitor; RNA interference

Online: 7 June 2021 (12:43:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0488.v1

Machine Learning Model for Diagnosing the Stage of Liver Fibrosis in Patients With Chronic Viral Hepatitis C

Valeriy Tsvetkov, Ivan Tokin, Dmitriy Lioznov

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Hepatitis C virus; Chronic viral hepatitis C; Liver fibrosis; Liver cirrhosis; Diagnosis of liver fibrosis; Machine learning

Online: 22 February 2021 (15:31:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0053.v1

Analysis of Environmental Factors Caused by Exposure to Air Pollution in Yeosu Industrial Complex: Analyzing Google Trend Trends in Cancer Generation through Big Data

Kil Yong Choi, BuSoon Son, WonHo Yang

Subject: Physical Sciences, Atomic And Molecular Physics Keywords: Google Trend; Particulate Matter; National Ambient Air Quality Monitoring Information System; Chronic obstructive pulmonary disease; Big Data

Online: 2 August 2020 (18:29:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0458.v2

Cost-sensitive Ensemble Feature Ranking and Automatic Threshold Selection for Chronic Kidney Disease Diagnosis

Syed Imran Ali, Bilal Ali, Jamil Hussain, Musarrat Hussain, Fahad Ahmed Satti, Gwang Hoon Park, Sungyoung Lee

Subject: Computer Science And Mathematics, Computer Science Keywords: Cost-sensitive feature selection; ensemble models; decision tree classifiers; chronic kidney disease; random forests; gradient boosted trees

Online: 6 July 2020 (09:56:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201906.0271.v1

The Effect of Health-Related Behaviors on Disease Progression and Mortality in Early Stages of Chronic Kidney Disease: A Nationwide Population-Based Study

Yookyung Lee, SuYeon Kwon, JongJoo Moon, Kyungdo Han, Nam-Jong Paik, Won-Seok Kim

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: chronic kidney disease; disease progression; end stage renal disease; mortality; health-related behaviors; physical activity; smoking; alcohol

Online: 26 June 2019 (15:38:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints201806.0134.v1

Chronic Pediatric Pain in Low and Middle Income Countries

Camila Walters, Matthew Kynes, Jenna Sobey, Tsitsi Chimhundu-Sithole, Kelly McQueen

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: chronic pediatric pain; low income country; middle income country; low and middle income country; pediatric palliative care.

Online: 8 June 2018 (12:45:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0166.v1

Development and Implementation of Reasonable Accommodation in Employment for Persons with Chronic Health Issues: An Exploratory Study in Slovenia

Aleksandra Tabaj, Dare S. Kovačič, Črtomir Bitenc, Valentina Brecelj

Subject: Social Sciences, Sociology Keywords: reasonable accommodation; employment; vocational/employment rehabilitation; persons with health issues; persons with disabilities; persons with chronic diseases

Online: 12 April 2018 (13:49:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0414.v1

Triple Therapy De-escalation and Withdrawal of Inhaled Corticosteroid to Dual Bronchodilator Therapy in Patients with Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review and Meta-Analysis

Edoardo Pirera, Domenico Di Raimondo, Antonino Tuttolomondo

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Chronic Obstructive Pulmonary Disease (COPD); inhaled corticosteroids (ICS); de-escalation therapy; Acute Exacerbation of COPD (AECOPD); pneumonia; eosinophils

Online: 6 September 2024 (05:51:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0257.v1

Manual Therapy Improves Fibromyalgia Symptoms by Downregulating SIK1

Javier Bonastre-Férez, Karen Giménez-Orenga, Francisco Javier Falaguera-Vera, María Garcia-Escudero, Elisa Oltra

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: fibromyalgia; myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); pressure point threshold (PPT); physiotherapy; manual therapy (MT); NCT04174300; SIK1

Online: 5 August 2024 (08:18:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0653.v1

Cholinergic Stimulation Exerts Cardioprotective Effects and Alleviates Renal Inflammatory Responses after Acute Myocardial Infarction in Spontaneous Hypertensive Rats (SHRs)

Pamela Nithzi Bricher Choque, Maria Helena Porter, Manuella da Silva Teixeira, Humberto Dellê, Rosilene Motta Elias, Bruno Durante, Marina Rascio Henriques Dutra, Christine N. Metz, Valentin A. Pavlov, Fernanda M. Consolim Colombo

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: acute myocardial infarction; cardiorenal syndrome; chronic kidney injury; Inflammation; autonomic nervous system; cholinergic stimulation; pyridostigmine bromide; vagus nerve

Online: 12 March 2024 (09:09:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0241.v2

Puerariae Lobatae Radix Ameliorates Chronic Kidney Disease by Reshaping Gut Microbiota and Down-Regulating Wnt / β-Catenin Signaling

Peng Wu, Jingwen Xue, Zhangrui Zhu, Yao Yu, Qi Sun, Ming Xie, Benlin Wang, Pengcheng Huang, Zhengyuan Feng, Jie Zhao

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Puerariae Lobatae Radix; High salt diet; Chronic kidney disease; Wnt / β -catenin pathway; Gut microbiota; Fecal microbiota transplantation

Online: 17 January 2024 (11:11:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0239.v1

Clinical Validation Of ANKRD36 Mutations As A Novel Biomarker For Monitoring Early Progression and Timely Clinical Interventions In Blast Crisis CML

Nawaf Al-anazi, Muhammad Absar, Abdulaziz Siyal, Salman Basit, Masood Shammas, Amer Mahmood, Sarah Almukhaylid, Zafar Iqbal

Subject: Medicine And Pharmacology, Hematology Keywords: Chronic Myeloid Leukemia; CML progression; Poor survival; Genomic instability; Blast crisis; ANKRD36; Clinical validation

Online: 3 January 2024 (10:25:49 CET)

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Background: Chronic Myeloid Leukemia (CML) is initiated in the bone marrow due to the chromosomal translocation t(9;22), resulting in the fusion oncogene BCR-ABL. Tyrosine kinase inhibitors (TKIs) targeting BCR-ABL have transformed fatal CML into an almost curable disease. However, TKIs lose efficacy during disease progression, and the mechanism of CML progression remains to be fully understood. Additionally, common molecular biomarkers for CML progression are lacking. Our studies previously detected ANKRD36 (c.1183_1184 delGC and c.1187_1188 dupTT) associated exclusively with advanced phase CML. However, clinical validation of this finding was pending. Therefore, this study aimed to clinically validate mutated ANKRD36 as a novel biomarker of CML progression. Materials and Methods: The study enrolled 124 patients in all phases of CML, recruited from Mayo Hospital and Hameed Latif Hospital in Lahore, Punjab, between January 2020 and September 2023. All response criteria were adopted from the European LeukemiaNet guideline 2020. Informed consent was obtained from all study subjects. The study was approved byscientific and ethical review committees of all participating centers. Sanger sequencing was employed to detect ANKRD36mutations in CML patients in accelerated phase (AP) (n=11) and blast crisis (BC) (n=10), with chronic-phase CML (CP-CML) patients as controls (n=103). Samples were processed using Big Dye Terminator Cycle Sequencing Ready Reaction kits and sequenced using ABI Prism 3730 Genetic Analyzer, and sequencing using forward and reverse primers for ANKRD36.Results: During our study, 17% of CML patients progressed to advanced phases AP-CML n= 11 (8.9%) and BC-CML n=10(8.1%). The chronic- and advanced-phase patients showed significant difference with respect to male-to-female ratio, hemoglobin level, WBC count, and platelet count. Sanger sequencing detected ANKRD36 mutations c.1183_1184 delGC and c.1187_1185 dupTT exclusively in all AP- and BC-CML patients but in none of the CP-CML patients. Nevertheless, mutations status was not associated with male-to-female ratio, hemoglobin level, WBC count, and platelet count, which makes ANKRD32 as an independent predictor of early and terminal disease progression in CML. Conclusions: The study confirms ANKRD36 as a novelgenomic biomarker for early and late CML progression. Further prospective studies should be carried out in this regard. ANKRD36, although fully uncharacterized in humans, shows the highest expression in bone marrow, particularly myeloid cells. Functional integrated genomic studies are recommended to further explore the role of ANKRD36 in the biology and pathogenesis of CML.

Preprint REVIEW | doi:10.20944/preprints202311.1772.v1

Identification of Putative Causal Relationships Between Blood-Based Biomarkers and Prediabetes-Induced Senescence: A Comprehensive Review

Nonkululeko Avril Mbatha, Aganze Gloire-Aime Mushebenge, Andile Khathi

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: prediabetes; senescence; blood-based biomarkers; aging; age-related diseases; inflammation; oxidative stress; vascular dynamics; metabolic disorders; chronic inflammation

Online: 29 November 2023 (04:48:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0276.v1

Elevated Expression of HSP72 in the Prefrontal Cortex and Hippocampus of Rats Subjected to Chronic Mild Stress and Treated with Imipramine

Adam Bielawski, Agnieszka Zelek-Molik, Katarzyna Rafa-Zabłocka, Marta Kowalska, Piotr Gruca, Mariusz Papp, Irena Nalepa

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: chronic mild stress; depression; imipramine; heat shock protein; HSP90; inducible HSP90A; constitutive HSP90B; HSP70; inducible HSP72; constitutive HSC70

Online: 6 November 2023 (11:35:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0367.v1

Disparities by Sex in Relation with Emotional Pre-Occupation and Variations in Stress Scores during Chronic Hemodialysis Management

Saira Akhlaq, Candace Ayars, Lynda Konecney, Monica Mitchell, Mohammad Zeeshan Qamar

Subject: Biology And Life Sciences, Behavioral Sciences Keywords: Coping; Stress; Hemodialysis; Emotional Preoccupation; Coping with Health Injuries and problems (CHIP); Chronic Kidney Disease Stress Inventory (CKDSI)

Online: 6 September 2023 (09:42:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.2093.v1

Semaphorin 3A Signaling in Kidney Development and Diseases

Yizhen Sang, Kenji Tsuji, Hiroyuki Nakanoh, Kazuhiko Fukushima, Shinji Kitamura, Jun Wada

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: semaphorin 3A; neuropilin-1; podocyte; diabetic nephropathy; acute kidney injury; chronic kidney injury; lupus nephritis; fibrosis; apoptosis; inflammation

Online: 31 August 2023 (02:53:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0065.v1

Arginine, Transsulfuration, and Folic Acid Pathway Metabolomics in Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis

Angelo Zinellu, Arduino A Mangoni

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: folic acid; transsulfuration; oxidative stress; nitric oxide; biomarkers; chronic obstructive pulmonary disease; homocysteine; asymmetric dimethylarginine; symmetric dimethylarginine; ornithine

Online: 1 August 2023 (09:04:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.1709.v1

Gastric Alimetry® Test Interpretation in Gastroduodenal Disorders : Review and Recommendations

Daphne Foong, Stefan Calder, Chris Varghese, Gabriel Schamberg, William Xu, Charlotte Daker, Vincent Ho, Christopher N. Andrews, Armen A. Gharibans, Greg O’Grady

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Gastroparesis; chronic nausea and vomiting; functional dyspepsia; body surface gastric mapping; disorders of gut brain interaction; motility disorders.

Online: 25 July 2023 (11:15:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.2076.v1

The Rationale for Sulforaphane to Favourably Influence Gut Homeostasis and Gut-Organ Dysfunction: a Clinician’s Hypothesis

Christine A. Houghton

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: sulforaphane; gut-organ axis; gut ecology; microbiome; chronic disease; nutrigenomics; nutritional medicine; food intolerance; epithelium, dysbiosis; gut barrier

Online: 29 June 2023 (08:06:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1854.v1

Investigation of Renal Function in Patients with Long COVID in the Amazon Region: A Cross-Sectional Study

Gabriela Maria Coimbra Coelho de Assis, Ian Gonçalves da Veiga, Rita de Nazaré Rayol Reis, Daniel Carvalho de Menezes, Stanley Soares Xavier, Jorge Rodrigues de Sousa, Juarez Antônio Simões Quaresma, Luiz Fábio Magno Falcão, Patrícia Danielle Lima de Lima

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: SARS-CoV-2; COVID -19; Chronic Kidney Disease; Long COVID; Acute Kidney Injury; Amazon region; Kidney function tests

Online: 27 June 2023 (07:20:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0095.v1

Improving Quality of Life in Chronic Patients: A Pilot Study on the Effectiveness of a Health Recommender System and Its Usability

Alberto del Rio, Jennifer Jimenez, Rodrigo Medina-García, Cristina Lozano-Hernández, Federico Alvarez, Javier Serrano

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: health recommender system; recommender system; sensorial ecosystem; continuous monitoring; chronic diseases; integrated care; quality of life; elderly care

Online: 6 April 2023 (12:23:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0408.v1

Stopping Feline Coronavirus Shedding Prevented Feline Infectious Peritonitis

Diane D. Addie, Flora Bellini, Johanna Covell-Ritchie, Ben Crowe, Sheryl Curran, Mark Fosbery, Stuart Hills, Eric Johnson, Carrie Johnson, Steven Lloyd, Os Jarrett

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: feline coronavirus; feline infectious peritonitis; FIP prevention; GS-441524; chronic enteritis; inflammatory bowel disease; IBD; antiviral; diarrhea; itraconazole.

Online: 23 January 2023 (09:43:21 CET)

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Preprint REVIEW | doi:10.20944/preprints202102.0319.v2

Factors Associated with Mortality Among Elderly People in the COVID-19 Pandemic (SARS-CoV-2): A Systematic Review and Meta-Analysis

Vicente Alves, Francine Casemiro, Bruno Araujo, Marcos Lima, Rayssa Oliveira, Fernanda Fernandes, Ana Vitória Gomes, Dario Gregori

Subject: Public Health And Healthcare, Other Keywords: SARS-CoV-2; COVID-19; Non-Communicable Chronic Diseases (NCCDs); Clinical features; Institucionalized or hospitalized elderly; meta-analisys.

Online: 1 July 2021 (11:21:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202008.0087.v1

Nasal Polyposis: Insights in Epithelial-mesenchymal Transition and Differentiation of Polyp Mesenchymal Stem Cells

Emanuela Chiarella, Nicola Lombardo, Nadia Lobello, Annamaria Aloisio, Teodoro Aragona, Corrado Pelaia, Stefania Scicchitano, Heather M. Bond, Maria Mesuraca

Subject: Medicine And Pharmacology, Otolaryngology Keywords: Chronic rhinosinusitis (CR); inflammation; nasal polyps; epithelial to mesenchymal transition (EMT); Polyp derived mesenchymal stem cells (PO-MSCs)

Online: 4 August 2020 (11:07:19 CEST)

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Working Paper ARTICLE

Randomized Clinical Trial Is Biased and Invalid In Studying Chronic Diseases, Compared with Multiple Factors Optimization Trial

Jianqing Wu, Ping Zha

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: clinical trial; statistical analysis; experimental error; chronic diseases; cancer; health optimization; hypothesis test; variance analysis; covariance; stratification; randomization

Online: 21 November 2019 (04:04:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints201908.0177.v1

Clinical Importance of Drug Adherence during Tyrosine Kinase Inhibitor Therapy for Chronic Myelogenous Leukemia in Chronic Phase

Yasuhiro Maeda, Atsushi Okamoto, Kenta Yamamoto, Go Eguchi, Yoshitaka Kanai

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: chronic myeloid leukemia; tyrosine kinase inhibitor; adverse drug event; quality of life; second-generation tyrosine kinase inhibitor; nilotinib

Online: 16 August 2019 (08:09:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1890.v1

Impaired Coordination of the Ciliary Movement in Patients with Chronic Rhinosinusitis with Nasal Polyps: The Role of Decreased Planar Cell Polarity Protein Expression

Sakura Hirokane, Tomohiro Kawasumi, Sachio Takeno, Yukako Okamoto, Seita Miyamoto, Rikuto Fujita, Chie Ishikawa, Takashi Oda, Yuichiro Horibe, Takashi Ishino, Takao Hamamoto, Tsutomu Ueda

Subject: Medicine And Pharmacology, Otolaryngology Keywords: paranasal sinus; chronic rhinosinusitis; CRS; nasal polyps; ciliated cell; mucociliary clearance; planar cell polarity; CPLANE complex proteins; WDPCP; FUZ

Online: 24 July 2024 (08:02:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0848.v1

Clinical and Diagnostic Features of Post-Acute COVID-19 Vaccination Syndrome (PACVS)

Anna Katharina Mundorf, Amelie Semmler, Harald Heidecke, Matthias Schott, Falk Steffen, Stefan Bittner, Karl J. Lackner, Karin Schulze-Bosse, Marc Pawlitzki, Sven Guenther Meuth, Frank Klawonn, Jana Ruhrländer, Fritz Boege

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: post-acute COVID-19 vaccination syndrome; PACVS; interleukin-6; interleukin-8; malaise/ chronic fatigue; cognitive impairment; peripheral nerve dysfunction

Online: 12 June 2024 (14:36:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0362.v1

Synergistic Responses Conferred by Concurrent Optical and Magnetic Stimulation are Attenuated by Simultaneous Exposure to Streptomycin: An Aminoglycoside Antibiotic Dilemma

Jan Nikolas Iversen, Jürg Fröhlich, Yee Kit Tai, Alfredo Franco-Obregón

Subject: Medicine And Pharmacology, Dermatology Keywords: wound healing; proliferation; magnetoreception; photomodulation; regenerative medicine; magnetic mitohormesis; mitochondria; reactive oxygen species; chronic wounds; hard-to-heal wounds

Online: 7 June 2024 (11:47:28 CEST)

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Concurrent Optical and Magnetic Stimulation (COMS) combines extremely low frequency electromagnetic and light stimulation modalities for enhanced wound healing. In this report, we investigated the potential mechanistic synergism between magnetic and light components by comparing their individual and combined cellular responses. Although each individual stimulation mode was capable of stimulating cell proliferation, magnetic fields exposure alone produced greater proliferation enhancement than light alone, yet their combined effects of were supra-additive of the individual responses. Reactive oxygen species were incrementally reduced by exposure to light, magnetics fields and their combination, where statistical significance was ultimately achieved. On the other hand, ATP production was significantly enhanced in response to magnetic exposure alone or in combination with light. These results suggest that mitochondrial respiratory efficiency was preferentially improved by the combination of the two stimuli. Protein expression related to cell proliferation was preferentially enhanced by the combinatory COMS modality as were the protein levels of the TRPC1 cation channel previously implicated as part of a calcium-mitochondrial signaling axis invoked by electromagnetic exposure and involved in proliferation. These results corroborate that light facilitates functional synergism with magnetic fields that ultimately impinge on mitochondria-dependent developmental responses. The aminoglycoside antibiotics (AGAs) have been previously shown to antagonize TRPC1-mediated magnetotransduction. Streptomycin applied during the exposure to any of the stimulation modes reduced proliferation enhancement, whereas streptomycin added after the exposure did not. Notably, the COMS modality and magnetic field exposure were capable of partially overcoming streptomycin antagonism of proliferation, whereas light alone was not. Transductional antagonism of combinatorial photon-electromagnetic effects by streptomycin thus aligns with previous studies showing that the AGAs block TRPC1-mediated magnetotransduction when applied during exposure. The prophylactic usage of the AGAs (neomycin) should be avoided during COMS therapy to maintain clinical efficacy and would be a common concern with most other electromagnetic regenerative paradigms.

Preprint REVIEW | doi:10.20944/preprints202404.2021.v1

A Narrative Review on Gut Microbiome Disturbances and Microbial Preparations in ME/CFS: Implications for Long COVID

Joanna Michalina Jurek, Jesus Castro-Marrero

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: probiotics; gut microbiota; gut-brain axis; chronic fatigue syndrome; myalgic encephalomyelitis; long covid; prebiotics; dietary supplementation; antioxidants; inflammation; psychobiotics

Online: 1 May 2024 (03:01:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.1023.v1

Exploratory Review of Takotsubo Syndrome and the Possible Role of the Psychosocial Stress Response and Inflammaging

Niklas Frank, Martin Lauer, Carola Förster

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Takotsubo syndrome; inflammaging; hypothalamic-pituitary-adrenal axis; sympathetic nerve action; central autonomic nervous system; glucocorticoids; chronic psychosocial/psychological stress

Online: 14 December 2023 (09:33:25 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.1603.v1

Navigating the Complexities of Traumatic Encephalopathy Syndrome (TES): Current State and Future Challenges

Arman F Fesharaki-Zadeh

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: chronic traumatic encephalopathy (CTE); Alzheimer’s disease (AD); traumatic encephalopathy syndrome (TES); traumatic brain injury (TBI); repetitive head impacts (RHI)

Online: 25 October 2023 (08:57:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.1240.v1

Advancements in Treatment Strategies for Chronic Mesenteric Ischemia: A Comprehensive Review

Genti Xhepa, Andrea Vanzulli, Lucilla Violetta Sciacqua, Agostino Inzerillo, Pierre Faerber, Anna Maria Ierardi, Gianpaolo Carrafiello, Filippo Del Grande, Alexis Ricoeur

Subject: Medicine And Pharmacology, Surgery Keywords: review; chronic mesenteric ischemia; superior mesenteric artery; revascularization; treatment; endovascular revascularization (ER); percutaneous transluminal angioplasty (PTA); primary stenting (PMAS)

Online: 19 October 2023 (10:14:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0113.v1

Chronic Fatigue and Dis-Autonomy following COVID-19 Vaccination is Distinguished from Normal Vaccination Response by Altered Blood Markers

Amelie Semmler, Anna Katharina Mundorf, Anna Sabrina Kuechler, Karin Schulze-Bosse, Harald Heidecke, Kai Schulze-Forster, Matthias Schott, Markus Uhrberg, Sandra Weinhold, Karl J. Lackner, Marc Pawlitzki, Sven Guenther Meuth, Fritz Boege, Jana Ruhrländer

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Post-Acute COVID-19 Vaccination Syndrome; PACVS, G-protein-coupled receptor; receptor antibody; interleukin-6; dis-autonomy; chronic fatigue.

Online: 4 September 2023 (07:14:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.2123.v1

Can Nutrition Contribute to a Reduction in Sarcopenia, Frailty, and Comorbidities in a Super-Aged Society?

Sadao Yoshida, Ryo Shiraishi, Yuki Nakayama, Yasuko Taira

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: sarcopenia; frailty; comorbidity; diabetes; chronic kidney disease (CKD); heart failure; dementia; vitamin D; oral nutritional supplement (ONS); elderly people

Online: 29 June 2023 (13:14:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.2095.v1

Can Nutrition Contribute to a Reduction in Sarcopenia, Frailty, and Comorbidities in a Super-Aged Society?

Sadao Yoshida, Ryo Shiraishi, Yuki Nakayama, Yasuko Taira

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: sarcopenia; frailty; comorbidity; diabetes; chronic kidney disease (CKD); heart failure; dementia; vitamin D; oral nutritional supplement (ONS); elderly people

Online: 29 June 2023 (11:05:54 CEST)

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