Samples of sunflower Waste Cooking Oils (WCOs) subjected to several cycles of frying were treated with water under four different combinations of temperature and pH. The variation of the chemical composition of the oil samples was monitored through headspace Solid-Phase Microextraction (HS-SPME) coupled with gas-chromatographic technique (GC), ¹H NMR spectroscopy and ESI⁺ mass spectrometry measurements. The possibility to modify the chemical composition of the recycled vegetable oil by tuning the water treatment parameters was exploited for the designing of a mini-plant for the production of bio-lubricants. A full description of the proposed prototype is also reported.

The beginning of industrialization human being has observed a variety of environmental troubles in the world. This industrialization has not only brought growth and affluence but ultimately troubled the ecosystem. One of the crashes is visible, in form of water contamination. Here the current study heavy metal contamination of water body has been discussed. Effluents from a great number of industries viz., tannery, textile, pigment & dyes, paint, wood processing, petroleum refining, electroplating, leather etc., have a major amount of heavy metals in their wastewater. The conventional technique of handling heavy metal pollution includes chemical oxidation, chemical precipitation, ion exchange, reverse osmosis, membrane separation, electrodialysis etc. These processes are expensive, energy intensive and frequently related with generation of poisonous by-product. Therefore, the adsorption has been examined as a cost-efficient technique of elimination of heavy metals from wastewater. In the current study different low-cost adsorbent has been a review as an abatement of heavy metal contamination from wastewater. These adsorbent comprise materials of natural origin like peat moss, zeolites, clay, and chitin are found to be an effective agent for removal of deadly heavy metals like Pb, Cd, Zn, Cu, Ni, Hg, Cr etc. Separately from these, a variety of agricultural wastes like rice husk, waste tea, neem bark, black gram; Turkish coffee, walnut shell etc. were also known as a powerful adsorbent for heavy metal removal. at the side of that low-cost industrial byproduct like fly ash, lignin, iron (III) hydroxide and red mud, coffee husks, Areca waste, tea factory waste, sugar beet pulp, battery industry waste, blast furnace sludge, waste slurry, sea nodule remains and grape stalk wastes have been discovered for their technical possibility to eliminate toxic heavy metals from impure water.

Municipal landfills play a vital role in disposing of the solid waste from a community. One of the biggest challenges landfill management face is when the available storage space is being reduced faster than the rate that was planned for. This shortening of the landfill lifecycle impacted the city of Wilmington, Delaware when it was found that their landfill had lost 11 years of its projected lifespan and would reach fully capacity within the next decade. In order to remedy the situation six alternative solutions were devised, with each having different costs (capital, operating, and transport) and varying lengths of landfill extension. This research used the principle of optimization via a LINDO program to determine which solution would achieve the longest landfill extension for the minimum total cost. Other constraints placed on the program include reducing the waste being sent to the landfill and to achieve a minimum of 25 additional years for the landfill. The calculated solution produced a cost reduction of $232.64 million dollars and 3.2 additional years of operation from the option that was eventually chosen by the landfill authority.

Little research has been done on occupational health ramifications of informal electronic waste (e-waste) recycling work, which is increasingly common in low- and middle-income countries, and very little is known about this in high-income countries. Our study evaluated informal and formal e-waste recycling workers in Chile, which was recently recognized as a high-income country. In 2017 we recruited 78 informal recycling workers from two cities, and 15 formal e-waste recycling workers from one recycling facility. Participants completed a questionnaire and health assessment regarding their involvement in, and potential impacts of, e-waste recycling, among other measures. Participants were primarily male, middle-aged, married with children, and had worked in e-waste recycling for an average of 12 years. Participants generally reported good health status, and chronic disease prevalence was similar to the national prevalence. Workers commonly reported exposures to several occupational stressors, including mental health stressors and noise, as well as insufficient income. Occupational injuries were common and use of safety equipment was low. No significant differences were found between informal and formal workers. Informal e-waste workers in Chile face occupational health challenges. The extent to which these issues impact the health of informal Chilean e-waste workers is unclear and warrants further research.

Due to rapid urbanization, the quantity of wastewater treatment plants (WWTP) has increased, and with it the amount of waste generated by them. Sustainable management of this waste can lead to the creation of energy-rich biogas through the fermentation process. This review presents recent advances in the anaerobic digestion process resulting in greater biogas production. Disintegration techniques for enhancing waste activated sludge fermentation can be generally partitioned into biological, physical and chemical, each of which are covered in this review. These disintegration techniques were compared mainly in terms of their biogas yield. It was found that ultrasonic and microwave disintegration provides the highest biogas yield (>500%); however, they are also the most energy demanding (>10,000 kJ kg-1 total solids).

The article presents an experience based on the design of DIY materials (Do-It-Yourself) as a phenomenon that contributes to the circular economy, making use of household waste and organic binders. The development context is the southernmost Industrial Design School in Latin America, where students are educated through the transfer of knowledge emphasized on the experimentation and territory assessment. Methodology corresponds to the traditional industrial design process, inserting DIY design of materials in the strategic stage. Objective and subjective variables are determined applied in the definition of new materials, being able to determine a range of proposals based on household waste. Citrus × Sinensis, Peperomia caperata (Piperaceae), Radiata pine veneers, among them, which are conceived by students to be self-produced at the user level. The results are materials elaborated based on household waste, exemplified with three types based on organic husks. Beyond findings associated to technique, compatibilities between residual materials and results expressed in materials and catalogs, it is possible to educate future designers on the innovative theme, with the potential to improve life quality of people and their environments.

Since the early 1980s, a large number of research works on enzymes from the red king crab hepatopancreas have been conducted. These studies have been relevant both from a fundamental point of view for studying the enzymes of marine organisms and in terms of the rational management of nature to obtain new and valuable products from the processing of crab fishing waste. Most of these works were performed by Russian scientists due to the area and amount of waste of red king crab processing in Russia (or the Soviet Union). However, the close phylogenetic kinship and the similar ecological niches of commercial crab species and the production scale of the catch provide the bases for the successful transfer of experience in the processing of red king crab hepatopancreas to other commercial crab species mined worldwide. This review describes the value of recycled commercial crab species, discusses processing problems, and suggests possible solutions to these problems. The main emphasis is placed on the enzymes of the hepatopancreas as the most highly salubrious product of waste processed from red king crab fishing.

The samples from lunar farside have great significance for the study of the Moon, and even the solar system. Chang’e-6 landed successfully on the southern mare of the Apollo basin and returned ~2 kg samples from lunar farside. To provide a better understanding for the background of the returned samples, we conducted detailed crater size-frequency distribution (CSFD) measurements in the Chang’e-6 landing region, the southern mare of the Apollo basin. The southern mare is divided into western mare (W region) and eastern mare (E region), and then subdivided into five sub-units (W1, W2, W3, W4, W5) and three units (E1, E2, E3), respectively, according to the elevation, Ti and Fe abundances. Within the W2 and W5 region, more detailed sub-units were divided. The results show that the southern mare generally have two epochs, one of the Imbrian period and the other of the Eratothenian period. The basalt eruption lasted for ~1.7 Ga, from 3.28 Ga of the eastern mare to 1.54 Ga of the western mare. W region is younger than E region, while the three units of E region has an age of ~3.2 Ga. The ages of the western mare basalts range from 2.98 Ga to 1.54 Ga, lasting for 1.4 Ga. It’s worth noting that the age of the basalt at the Chang’e-6 sampling site is ~1.68 Ga, indicating the samples returned may include components with this very young age.

Although metastasis-associated protein 1 (MTA1) is known to play a role in cancer invasion and metastasis of various cancers, the clinical significance of its expression in canine urothelial carcinoma (UC) has not been explored. We sought to evaluate the expression of MTA1, cyclooxygenase 2 (COX2) and E-cadherin (E-cad) in association with clinicopathological parameters in clinical samples of canine UC. Here, we show that MTA1 and COX2 are overexpressed in canine UC samples compared to normal canine bladder samples, whereas E-cad levels are higher in normal bladder. The results demonstrated that MTA1 expression correlated with aggressive clinicopathological features such as high tumor-grade, muscular/vascular invasion, and metastasis. The expression of MTA1 differed in tumors depending on their localization, with the highest being in the urethra adjoining the prostate. Unexpectedly, higher E-cad levels were detected in metastatic tumor cells compared to primary tumor cells. Overall, these findings suggest that MTA1 may represent a key upstream effector tightly associated with COX2 and E-cad-mediated events in canine UC. Accordingly, MTA1 may be considered a feasible interceptive and therapeutic target for canine UC treatment.

There is limited evidence showing how developing universities in South Africa have successfully adopted and effectively used online learning to support students for positive learning experiences. Presently, there are numerous challenging factors with regards to Information and Communication Technology (ICT) adoption in South African developing universities. The purpose of this paper was to investigate the extent of online learning support for student learning at developing universities in South Africa. The study resides in an interpretive framework from a philosophical perspective as it adopts a hermeneutic framework, with the literature obtained being classified, mapped, critically assessed, and themes and arguments developed. There is scant evidence of studies conducted and published between 2000 and 2024 on online learning support as a pedagogical strategy for student learning in the developing universities in South Africa. The findings resulted in five emerging themes from the literature review. These major themes include lack of ICT governance; poor digital infrastructure; lack of ICT skills; budget constraints; and accessibility and inclusivity challenges. This study is expected to have a significant impact on the development of universities' online learning policies and practices. It will also contribute to the pedagogical strategies and frameworks of academics and scientific knowledge on how scholars should perceive online learning support in the context developing universities.

This qualitative research explores the integration of digital technologies to enhance supplier engagement in e-commerce, examining the transformative impact of AI, blockchain, and IoT on supplier relationship management (SRM). Through semi-structured interviews and documentary analysis with 15 industry experts, the study reveals that digital technologies enable organizations to optimize supply chain operations, improve transparency, and foster collaborative partnerships with suppliers. Strategic initiatives such as co-development projects and joint innovation efforts are pivotal in accelerating product development cycles and enhancing market competitiveness. Emotional intelligence (EI) emerges as critical in cultivating trust, empathy, and effective communication, underscoring the human dimension of supplier relationships amidst technological advancements. Challenges identified include technological complexity, data privacy concerns, and resistance to change, necessitating robust cybersecurity measures and proactive compliance strategies. Economically, organizations benefit from significant cost savings, improved efficiency, and enhanced profitability through digital transformation initiatives in SRM. By leveraging digital platforms and data-driven insights, organizations can optimize procurement processes, streamline operations, and mitigate risks to achieve sustainable growth and resilience.

Robotic-assisted hip and knee arthroplasty represents significant advancements in orthopedic surgery. Artificial intelligence (AI) - driven chatbots, such ChatGP, plays a significant role in healthcare education. This study aims to evaluate the quality of responses provided by ChatGPT to the top 20 questions concerning robotic-assisted hip and knee arthroplasty.We have asked ChatGPT to select the top 20 questions on Google concerning robotic hip and knee arthroplasty and to provide a detailed answer to each of them. The accuracy of the information provided were examined by three orthopedic surgeons with scientific and clinical experience in hip and knee replacement surgery. The accuracy was assessed through a 5-point Likert scale (from 1 – completely incorrect to 5 – correct); the completeness through a 4-point Likert scale (from 0 – comprehensiveness not assessable for completely incorrect answers to 3 – exhaustive information) on two different occasions to ensure the consistency of the assessment. Our analysis reveals that ChatGPT provides a relatively high degree of accuracy, moreover the explanations can be considered satisfy, especially for factual questions. The findings suggest that ChatGPT can serve as a valuable initial resource for general information on robotic hip and knee arthroplasty but the integration with human expertise remains essential.

Viral hepatitis is currently acknowledged as a significant public health issue that necessitates a prompt and immediate response. Hepatitis is a significant worldwide health problem that causes the death of approximately 1.5 million individuals annually. The objective of this study was to ascertain the occurrence rate of hepatitis A, E, B, and C infections in the Hajjah governorate of Yemen from 2020 to 2023.A retrospective study was conducted in the Hajjah Governorate of Yemen for four years, 2020– 2023. About 41162 cases were collected from the clinical records of epidemiological surveillance in the Public Health Office of the Hajjah Governorate. All cases were diagnosed in different laboratories based on direct observation of viral hepatitis in the blood sample. The required data were obtained by using the designed questionnaire. The findings of the present investigation were summarized as follows: The current findings indicate that the prevalence rate of Hepatitis A and E was 761 (1.85%), while the prevalence rate of Hepatitis B and C was 971 (2.36%) among the participants of the study. The current findings indicate that the incidence of Hepatitis A and E was greater in 2022 (2.3%), while Hepatitis B and C had a higher rate in 2020 (2.9%). The study revealed a higher prevalence of hepatitis A and E among individuals originating from Al Miftah district 116, with a rate of 7.5%. Furthermore, the prevalence of hepatitis B and C in Hajjah city was significantly higher, reaching 579 cases (22.9%). The month with the highest incidence of hepatitis A and E viruses was September, with a rate of 85 cases (2.6%), while the lowest incidence was observed in April, with a rate of 1.3%. The prevalence of hepatitis B and C viruses was highest in October 1997, with a rate of 2.8%, followed by November 1997 with the same rate. The lowest observed incidence of 1.6% was recorded in April. In Autumn, a significant prevalence of hepatitis A and B viruses, as well as hepatitis B and C viruses, was identified at rates of 2.2% and 2.6%, respectively.The study findings indicate that the occurrence of HAV, HEV, HBV, and HCV in the study area is consistent with global trends. Although the study found a low prevalence of hepatitis viruses, these types of viruses will continue to pose a significant risk to public health. Based on this study, it is imperative for authorities to actively enhance public awareness in order to enable prompt planning and essential arrangements for an effective response to outbreaks or epidemics. This will ultimately lead to a reduction in illness, death, and economic burden.

SARS-CoV-2 is an obligatory intracellular pathogen that requires of a lipid bilayer membrane for its transport, to build its nucleocapsid envelope and to fuse with the host cell. The biological membranes are constituted by phospholipids (PLs) and vitamin E (Vit E) protects them from oxidative stress (OS). The aim of this study was to demonstrate if the treatment with Vit E restores the modified profile of the FA in PLs in serum from patients with coronavirus disease-19 (COVID-19). We evaluated Vit E, total fatty acids (TFA), fatty acid of the phospholipids (FAPL), total phospholipids (TPLs), 8-isoprostane, thromboxane B2 (TXB2), prostaglandins (PGE2 and 6-keto-PGF1α), interleukin-6 (IL-6) and C-reactive protein (CRP) in serum from 22 COVID-19 patients before and after treatment with Vit E and compared the values with those from 23 healthy subjects (HS). COVID-19 patients showed a decrease in Vit E, TPLs, FAPL and TFA in serum in comparison to HS (p≤0.01) and Vit E treatment restored their levels (p≤0.04). Likewise, there was an increase IL-6 and CRP in COVID-19 patients in comparison with HS (p≤0.001) and the treatment with Vit E decreased their levels (p≤0.001). Treatment with Vit E contributes to restore the modified profile of the PLs in the SARS-CoV-2 infection and this leads to a decrease of OS and of the inflammatory process.

The present study aimed to clarify the relationship between brand awareness and word-of-mouth communication in the fast-food sector, Lambayeque Region, 2023. By adopting a quantitative approach, statistical tools were utilized to measure variables and address hypotheses and objec-tives. The study was correlational in nature, as it demonstrated the relationship between brand awareness and word-of-mouth communication. It was also applied in scope, disseminating learning based on the research that will assist the studied area. Furthermore, this study employed a nonexperimental, cross-sectional design because the variables were only analyzed in the workplace environment at a single point in time and were not manipulated. According to the results, it is evident that consumers will easily recall their favorite brands, provided these brands meet their expectations are deemed significant, and the information on social networks is updated, detailed, useful, and valuable. Moreover, they are likely to recommend them if they recognize and have a positive valuation of the brand, sharing favorable information about it on their social networks and with their peers. The study concludes that virtual interactivity and the quality of information are linked to the generation of brand awareness, which in turn was shown to be a predictor of eWOM.

Presence of lipopolysaccharides (LPSs) in the outer layer of outer membranes (OMs) is an almost universal molecular signature of Gram-negative bacteria. The O-antigen or O-polysaccharide (OPS) chains attach to millions of LPS molecule to form a continuous layer on the surface of most of Escherichia coli strains. OPS structure is one of the most variable features of bacteria, with about 200 E. coli O-serotypes currently described. In this review a analyze accumulating evidence suggesting that a vast majority of these OPS types provide robust shields that restrict the access of large molecules to the OM surface. Sophisticated mechanisms employed by bacteriophages to penetrate the OPS barrier are also considered. These are initiated with specific recognition of OPS molecules by phage receptor-binding proteins (RBP), or of other cell-surface molecules that are exposed above the OPS layer. Only after can virions gain access to secondary receptors found closer to the OM surface. The mechanisms of breaking through OPS in most if not all cases appear to rely on mechanical force generated by molecular motors of processive depolymerization or deacetylation of cell surface polysaccharides by enzymatically active RBPs, or by internal rearrangement of the virion.

Energy efficiency considerations in terms of reduced power dissipation is a significant issue in the design of digital circuits for very large-scale integration (VLSI) systems. Quantum-dot cellular automata (QCA) is an emerging ultra-low power dissipation approach, distinct from the traditional complementary metal-oxide semiconductor (CMOS) technology, for building digital computing circuits. Developing fully reversible QCA circuits has the potential to significantly reduce energy dissipation. The multiplexer is a fundamental element in the construction of useful digital circuits. In this paper, a novel, multilayer, fully reversible QCA 8:1 multiplexer circuit, with ultralow energy dissipation, is introduced. The proposed multiplexer power dissipation is simulated using the QCADesigner-E version 2.2 tool, describing the microscopic physical mechanisms underlying the QCA operation. The results showed that the proposed reversible QCA 8:1 multiplexer consumes 89% less energy than the most energy-efficient 8:1 multiplexer circuit presented previously in the scientific literature.

Hepatitis E virus (HEV) is a zoonotic foodborne virus with an annual infection prevalence of 20 million human cases, which seriously affects public health and economic development in both developed and developing countries. To better understand the epidemiology of HEV in the Centre of Portugal, a cross-sectional study was conducted from 2016 to 2023 with sera samples from wild ungulates. The seroprevalence and risk factors for HEV seropositivity were evaluated in the present study. Specifically, antibodies against HEV were determined by a commercial enzyme-linked immune-sorbent assay (ELISA). Our results show that in the 650 sera collected from 298 wild red deer and 352 wild boars from Portugal, 9.1% red deer (95% confidence interval [CI]: 6.312.9%) and 1.7% wild boar (95% CI: 0.63.3%) were positive for antibodies to HEV. Regarding age, the seropositivity in juvenile wild ungulates was 1.3% (95% CI: 0.273.72%) and 7.2% in adults (95% CI: 4.910.11%). Logistic regression models investigated risk factors for seropositivity. The odds of being seropositive was 3.6 higher in adults than in juveniles (95% CI: 1.7218.11%) and the risk was 4.2 higher in red deer than in wild boar (95% CI: 1.64–10.69%). Both wild ungulate species were exposed to HEV. The higher seroprevalence in red deer suggests that this species may have a major contribution to the ecology of HEV in the Centre of Portugal. Further research is important to understand how wildlife affects the epidemiology of HEV infection in Portugal.

Rapid proliferation of traditional gold mining sites in Kédougou a Southeast region in Senegal, led to mass population migration from the neighboring West African countries and rapid expansion of small mining villages with poor hygiene and sanitation conditions. An outbreak of hepatitis E was reported in 2014 with several cases of febrile jaundice among traditional mine workers. In this study, we analyzed both HEV IgM and IgG seroprevalence and the associated risk factors of infection by testing any suspected case and contacts collected from February 2012 to November 2014. RNA-negative sera from suspected cases and contacts were tested for anti-HEV IgM and anti-HEV IgG. A total of 799 sera were collected from 290 suspected cases, 470 contacts and 39 individuals with missing information. The median age of the cohort study was 19 years (1-88 years) with a male/female sex-ratio of 1.9. We found an overall prevalence of 43.68% (332/760) of anti-HEV IgM and 38.15% (290/760) of anti-HEV IgG sera. Our data provide new insights into the HEV epidemiology and point to the crucial need to estimate the disease’s burden in Kédougou and assess the viral mechanisms driving the disease’s severity in pregnant women.

Background: Ovarian cancer is the leading cause of death from gynecological malignancies with serous carcinoma being the most common histopathologic subtype. Epithelial-Mesenchymal Transition (EMT) correlates with an increased metastatic potential, whereas the transcription factor SOX11 is overexpressed in diverse malignancies. Methods: In the present study, we aim to evaluate the potential role of the immunohistochemical expression of SOX11 in 30 serous ovarian carcinomas in association with E-cadherin and Vimentin expression as well as with patients’ clinicopathological data. Results: Most of the examined cases showed concurrent expression of E-cadherin and Vimentin, whereas SOX11 was expressed in a minority of the cases (26,7%). Interestingly, the positive cases had more frequently a metastatic disease at the time of diagnosis compared to the negative cases (p=0.09), an association, however, of marginal significance. Moreover, there was a negative correlation between E-Cadherin and SOX11 expression (p=0,0077) and a positive correlation between Vimentin and SOX11 expression (p=0,0130). Conclusions: The present work, for the first time, provides preliminary evidence SOX11 overexpression alongside E-cadherin loss in the promotion of EMT in serous ovarian cancer, thereby endorsing tumor metastasis.

The reference method for cefiderocol antimicrobial susceptibility testing is broth microdilution (BMD) with iron-depleted-Mueller-Hinton (ID-MH) medium, whereas breakpoints recommended for disk diffusion (DD) are based on MH-agar plates. We aimed to compare the performance of the commercial BMD tests ComASP (Liofilchem) and UMIC (Bruker), DD and E-test using MH- and ID-MH-agar plates with the reference BMD method using 100 carbapenem-resistant-A. baumannii isolates. Standard BMD was performed according to the EUCAST guidelines, DD and E-test were carried out using two commercial MH-agar plates (bioMérieux and Liofilchem) and an in-house ID-MH-agar plate, while ComASP and UMIC were performed according to the manufacturer’s guidelines. DD performed with the ID-MH-agar plates led to a higher categorical agreement (CA, 95.1%) with standard BMD and fewer categorization errors compared to the commercial MH-agar plates (CA bioMérieux 91.1%, Liofilchem 89.2%). E-test on ID-MH-agar plates exhibited a significantly higher essential agreement (EA, 75%) with standard BMD compared to the two MH-agar plates (EA bioMérieux 57%, Liofilchem 44%), and showed a higher performance in detecting high-level resistance than ComASP and UMIC (mean log2 difference with standard BMD for resistant isolates of 0.5, 2.83 and 2.08, respectively). In conclusion, DD and E-test on ID-MH-agar plates exhibit a higher diagnostic performance than on MH-agar plates and the commercial BMD methods. Therefore, we recommend using ID-MH-agar plates for cefiderocol susceptibility testing of A. baumannii.

E-commerce has gained increased popularity over the last decade. To date, there is an open debate as to whether e-commerce or brick-and-mortar shopping is environmentally less sustainable, especially due to the growing mobility resources needed for e-commerce distribution. The analysis at hand compares the CO2-equivalent emissions of e-commerce and brick-and-mortar shopping of pharmaceutical products considering spatial aspects and the typical transport modal mix of consumers when doing online and offline shopping. The object of analysis is a retailer of pharmaceutical products, more precisely medicines, which offers, both, brick-and-mortar shop and online shopping possibilities. The results show that spatial aspects concerning the residential location of consumers, the vehicles used for shopping trips, the shopping basked size, and trip-chaining effects have a crucial impact on the mobility demand and CO2-equivalent emissions of the two commerce forms. In general, for rural and sub-urban areas, e-commerce results in lower CO2-equivalent emissions, while in urban areas, brick-and-mortar shopping is the favourable solution, if the consumers walk or cycle to the next pharmacy.

Academic and corporate research has been focusing on analyzing stock performances, financial markets, and investment strategies for decades. According to Lynch and Rothchild (1989), certain investments can be described as plays. In this work, the authors use the term for investments in value stocks, spin-offs, and turnarounds to analyze the long-term stock performance and risk-adjusted excess returns of up to five years for those stocks. Additionally, stocks with a supe-rior return performance are identified within an investment play based on low P/E and P/B mul-tiples. The study finds that value stocks, spin-offs, and turnarounds outperform the S&P 500 on average on a one-, three- and five-year investment horizon. The analysis of the three investment plays confirms earlier studies that investment plays constitute a profitable investment opportunity. Moreover, the research exemplifies that private investors could achieve an excess return (alpha) through a passive buy-and-hold investment strategy. Overall, the analysis provides a deeper in-sight into the long-term performance of value stocks, spin-offs, and turnarounds.

The formation and localization of sporadic E(Es) layers predicted by the ions vertical drift velocity and its vertical change in the lower thermosphere during nighttime are shown analytically and by numerical simulations. The consideration of existence of a minimum negative value of the vertical change of the ions vertical drift velocity as a necessary condition of formation of Es layer and determining ions convergence rate into this layer, is extended in case of the presence of vertical wind. Upward vertical wind can shift the convergence regions upward, while downward vertical wind shift them downward, unlike the cases of presence of only meridional and zonal winds. It also changes the ion convergence rate compared to the one with just a horizontal wind. It is shown for the first time that the upward constant wind also causes the convergence of ions with maximum rate in the region where the ion-neutral collision frequency is equal to their cyclotron frequency. While demonstrating the presented theory by numerical simulations, HWM14 data is used for the meridional and zonal wind velocity profiles and the presence of its vertical component is assumed. In this case, in addition to the estimated ion drift velocity and its vertical changes, their initial distribution and ambipolar diffusion also determine the development of ion convergence/divergence processes. For small magnitude of vertical wind velocity, its significant influence on the ions/electrons behavior is demonstrated, which shows the importance of both tidal wind and wind changes caused by the propagation of atmospheric gravity waves on the formation of the Es layer. In this theoretical research it is shown that the realistic profile of the wind velocity, which takes into account the vertical component along with its zonal and meridional ones, is important for prediction of the Es layers formation, as well as regions of ion depletion.

The factors influencing hepatitis E virus (HEV) circulation remain largely unexplored. We investigated HEV seroprevalence in humans and the prevalence of infection in farm pigs and rabbits in different regions of the Russian Federation, as well as the genetic diversity and population dynamics of HEV. Anti-HEV IgG antibody detection rates in the general population increase significantly with age, from 1.5% in children and adolescents under 20 years old to 4.8% in adults aged between 20 and 59 years old, to 16.7% in people aged 60 years and older. HEV seroprevalence varies between regions, with the highest rate observed in Belgorod Region (16.4% compared with the national average of 4.6%), which also has the country’s highest pig population. When compared with the archival data, both increases and declines in HEV seroprevalence have been observed within the last 10 years, depending on the study region. Virus shedding has been detected in 19 out of the 21 pig farms surveyed. On one farm, circulation of the same viral strain for five years was documented. All human and animal strains belonged to the HEV-3 genotype, with its clade 2 sequences being predominant in pigs. Sequences from patients, pigs, and sewage from pig farms clustered together, suggesting a zoonotic infection in humans and possible environmental contamination. The HEV-3 population size predicted using SkyGrid reconstruction demonstrated exponential growth in the 1970s–1990s, with a subsequent decline followed by a short rise around the year 2010, the pattern being similar to the dynamics of the pig population in the country. The HEV-3 reproduction number (Re) predicted using Birth-Death Skyline analysis has fluctuated around 1 over the past 20 years in Russia, but is 10 times higher in Belgorod Region. In conclusion, HEV-3 circulation varies both geographically and temporally, even within a single country. The possible factors contributing to this variability are largely related to the circulation of the virus among farm pigs.

Background Content marketing is increasingly important for online branding. Brand popularity can be more easily determined online than sales-based measures but is not yet well-explained from a content marketing perspective. Promising predictors are open data syndication policies, connectivity to e-commerce platforms, product reviews, data health, and the depth and width of a brands product portfolio. A predictive content marketing model can help brand owners to understand their e-commerce potential. Methods We used brand popularity (Brand Popularity Rank) and catalog data in combination with product reviews from an independent content aggregator. For all datasets, we selected the overlapping dataset for brand popularity and brand reviews based on a period of 90 days from June 10, 2022, till September 24, 2022 (n = 333 brands). Backward stepwise multiple linear regression was used to develop a predictive content marketing model of the Brand Popularity Rank. Results Through stepwise backward multiple linear regression five highly significant (p < 0.01) predictive factors for brand rank are selected in our content marketing model: the brand’s data syndication policy, the number of connected e-commerce platforms, a brand’s number of products, its number of products per category, and the number of product categories in which it is active. Our model explains 78% of the variance of Brand Popularity Rank and has a good and highly significant fit: F (5, 327) = 233.5, p < 0.00001. Conclusions We conclude that a content marketing model can adequately predict a Brand Popularity Rank based on online popularity. In this model an open content syndication policy, more connected e-commerce platforms, and catalog size, i.e., presence in more categories and more products per category are each related to a better (lower) Brand Popularity Rank score.

Several biomedical products, like scaffolds, implants, prostheses, and orthoses, require materials having superior physicochemical and biological properties. Polyethylene terephthalate glycol (PETG) is being increasingly used for various biomedical applications. There are a few studies on PETG-based composites, however, natural fibers like silk short fibers reinfored PETG composites have not been attempted. Being a cost-effective widely available material, PETG-Silk combination can be potential biocomposite for several biomedical applications. Here, we report a novel short silk fiber reinforced PETG composite prepared by a wet-mixing route, ensuring homogenous dispersion of the filler. Different ratios (2-10%) of short silk fibers were used to prepare composites with varied compositions. The mechanical, physicochemical, and biological properties of the prepared composites were analyzed. Thermogravimetric analysis showed that such composites are thermally stable up to 390 °C and can be used for thermal extrusion-based manufacturing. The tensile modulus of the samples increased with fiber content; however, the failure strain reduced with fiber content. Furthermore, upon annealing, the tensile modulus increased but, the failure strain of the composites decreased, XRD study revealed that heat treatment has altered the crystalline nature of the composites. Finally, we evaluated the cytocompatibility of the prepared composites to assess their suitability for various biomedical applications.

We transformed the existing learning program Language Shower, which is used in some Norwegian day-care centers in the Grorud district of Oslo municipality, into a digital solution using an app for smartphone or tablet with the option for further enhancement of presentation by a NAO robot. The solution was tested in several iterations and multiple day-care centers over several weeks. Measurements of the children’s progress across learning sessions indicate a positive impact of the program using a robot as compared to the program without robot. In-situ observations and interviews with day care center staff confirmed the solution’s many advantages, but also revealed some important areas for improvement. In particular, the speech recognition needs to be more flexible and robust, and special measures have to be in place to handle children speaking simultaneously.

Development of supervised AI algorithms requires a large amount of labeled images. Image labelling is both time-consuming and expensive. Therefore, we explored the value of e-learning derived annotations for AI algorithm development in medical imaging. Methods We have developed an e-learning platform that involves image-based single click labelling as part of the educational learning process. Ten radiology residents, as part of their residency training, trained the recognition of pneumothorax on 1161 chest X-rays in posterior-anterior projection. Using this data, multiple AI algorithms for detecting pneumothorax were developed. Classification and localization performance of the models was tested on an independent internal testing dataset and on the public NIH ChestX-ray14 dataset. Results The AI models F1 scores on the internal and the NIH dataset were 0.87 and 0.44, respectively. Sensitivity was 0.85 and 0.80 for classification and specificity 0.96 and 0.48 for classification. F1 scores were 0.72 and 0.66, sensitivity 0.72 and 0.72. False positive rate was 0.36 and 0.32 for localisation. Conclusion Our results demonstrated that e-learning derived annotations are a valuable data source for algorithm development. Further work is needed to include additional parameters such as user performance, consensus of diagnosis, and quality control in the development pipeline.

Abstract: Commercialization of extra virgin olive oil (EVOO) requires a best before date recom-mended at up to 24 months after bottling, stored under specific conditions. Thus, it is expected that the product retains its chemical properties and preserves its ‘extra virgin’ category. However, in-adequate storage conditions could alter the properties of EVOO. In this study, Arbequina EVOO was exposed to five storage conditions for up to one year to study the effects on the quality of the oil and the compounds responsible for flavor. Every 15 or 30 days, samples from each storage condition were analyzed determining physicochemical parameters, the profiles of phenols, volatile compounds, α-tocopherol and antioxidant capacity. Principal component analysis was utilized to better elucidate the relationships between composition of EVOOs and the storage conditions. EVOOs stored at -23 and 23 °C in darkness and 23 °C with light, differed from the oils stored at 30 and 40 °C in darkness. The former were associated with higher quantity of non-oxidized phenolic compounds and the latter with higher elenolic acid, oxidized oleuropein and ligstroside derivatives, which also increased with storage time. E-2-Nonenal (detected at trace levels in fresh oil) was selected as a marker of the degradation of Arbequina EVOO quality over time, with significant linear regressions identified for the storage conditions at 30 and 40 °C. Therefore, early oxidation in EVOO could be monitored by measuring E2-Nonenal levels.

Pediculus humanus capitis, the head louse, is an obligate blood-sucking ectoparasite that occurs in six divergent mitochondrial haplogroups (A, D, B, F, C and E), each exhibiting a particular geographic distribution. A few years ago, several studies reported the presence of different pathogenic agents in head lice specimens from different clades collected worldwide. These findings suggest that head louse could be a vector for dangerous diseases and therefore a serious public health problem. Herein, we aimed to study the mitochondrial genetic diversity, the PHUM540560 gene polymorphisms profile of head lice collected in Guinea, as well as to screen for the pathogens present in these lice. In 2018, a total of 155 head lice were collected from 49 individuals at the Medicals Centers of rural (Maférinyah village) and urban (Kindia city) areas, in Guinea. All head lice were subjected to genetic analysis and screened for the presence of several pathogens using molecular tools. The results showed that all head lice belonged to the haplogroups C/E using the duplex qPCR which detects both clades. Standard PCR and sequencing revealed that all specimens belonged to the haplogroup E, including 8 haplotypes, whither 6 new identified for the first time in this study. The study of the PHUM540560 gene polymorphisms in our Guinean head lice revealed that 7/40 (17.5%) of our tested samples exhibit three different polymorphism profiles compared to the clade A-head lice PHUM540560 gene profile, while the remaining specimens 33/40 (82,5%) showed the same PHUM540560 gene polymorphism profile as the previously reported clade A-body lice. Molecular investigations of the targeted pathogens revealed only the presence of Acinetobacter species in 9% of our samples using real time PCR. Sequencing results identified highlighted the presence of several Acinetobacter species, including Acinetobacter baumannii (14.3%), Acinetobacter nosocomialis (14.3%), Acinetobacter variabilis (14.3%), Acinetobacter haemolyticus (7.2%), Acinetobacter towneri (7.2%). Furthermore, a candidate new species of Acinetobacter sp. (7.2%) was detected. Positive specimens were collected from 24,5% individuals in Maférinyah. We also investigated in our study the carbapenem’s-resistant profile of A. baumannii, none of our specimens were positive for the following resistance genes blaOXA-21, blaOXA-24 and blaOXA-58. To the best of our knowledge, our study is the first to report the existence of the Guinean haplogroup E, the PHUM540560 gene polymorphism profile as well as the presence of Acinetobacter species in head lice collected from Guinea.

RAD51 is a recombinase that plays a pivotal role in homologous recombination. Although the role of RAD51 in homologous recombination has been extensively studied, it is unclear whether RAD51 can be involved in gene regulation as a co-factor. In this study, we found in silico evidence that RAD51 may contribute to the regulation of genes involved in the autophagy pathway through interaction with E-box proteins such as USF1, USF2, and/or MITF in GM12878, HepG2, K562, and MCF-7 cell lines. The canonical USF binding motif (CACGTG) was significantly identified at RAD51 binding sites in all four cell lines. In addition, genome-wide USF1, USF2, and/or MITF-binding regions significantly coincided with the RAD51-binding sites in the same cell line. Interestingly, the promoters of genes associated with the autophagy pathway were significantly occupied by RAD51 in all four cell lines. Taken together, these results predicted a novel role of RAD51 that had not been addressed previously, and provided evidence that RAD51 could possibly be involved in regulating genes associated with the autophagy pathway, through interaction with E-box binding proteins.

Around the world, there is no population clear from urinary tract infection (UTI), particularly among women. UTI is considered the most predominant bacterial infection. This study aimed to detect the incidence of the most common major uropathogens in patients severe from urinary tract infection with antibiotic sensitivity tests that assist urologist doctors for appropriate antimicrobial empirical therapy.Methods: This study was carried in a private laboratory in Babil city, Iraq from May 2019 to May 2020. Totally 70 individuals suffering from clear symptoms of UTI, as well as, 20 healthy persons participated in this study as a control group. Then, the standard microbiological methods carried out to isolate and identify bacterial species. Antimicrobial susceptibility tests were performed using different antimicrobial discs by applying the Kirby–Bauer disc diffusion method.Results: Totally, 90 specimens were obtained from them 20 control group, 19 with no growth, and 51 patients with bacterial growth distributed as 43 (83%) females and 8 (17%) males. E. coli were the most common predominant organisms. All isolates were showed a high rate of resistance to evaluated cephalosporins 100% and 82% to cefotaxime and ceftriaxone respectively, while very low resistance recorded in Aminoglycosides 20% and 13% to Gentamicin and amikacin respectively. Most age group infected with UTI was 21-40 years old.Conclusion: The current study showed an increasing burden of urinary tract infection caused by various bacteria implicated in UTI that causes changeable sensitivity to various antimicrobial agents. Therefore, in clinical use appropriate medications should be selected based on the data obtained from antimicrobial susceptibility tests.

Background: The evolution of names, from “medical informatics” to “connected health”, implies that the evolvement of technology in health care has been shifted from technology-oriented to healthcare-oriented implementation. Connected healthcare, a healthcare platform of remote monitoring and self-management through technological measures, is suggested to contribute to the efficiency, cost effectiveness, and satisfaction of healthcare recipient enhancement. However, limited understanding of related connected health (CH) terminology may constrain its implementation. Whether CH is a Buzzword only or a practice that can contribute to an ageing society is controversial. Objective: This study aims to distinguish CH-related terminology and to identify the trend of CH through reviewing its definition, initiation, development, and evolvement, in order to offer management insights and implications. The objective is to understand what is connected and who is cared about in the connected health model, so that better applications can be addressed for the benefit of society. Method: This study reviews the evolution of names, from “medical informatics” in the 1970s to “connected health” after 2000, as well as relevant literature of CH, including e-health, telemedicine, telehealth, telecare, and m-health, to discover the trend of technology-related healthcare implementation. The current status and issues facing CH will be presented and its future trends will be explored through reviewing how changes in healthcare are managed, in addition to its operation and practice. Issues of accessibility, quality, and cost will be discussed, as well as its market status. Results: Preconditions and requirements for implementing CH are identified to select a typical case to study. Areas with a complete business ecosystem, including advanced technology and medical services, a payment system, an ageing population, geographic isolation, integrated health, and social care, are prevalent. These findings may be beneficial to designing and establishing comprehensive CH implantation and environments. Conclusion: The evidence and tendency of technological convergence create a demand for innovation and partnering with start-up companies that offer a competitive advantage in innovation. Specifically, it is necessary to innovate both the public and private operation model of the CH ecosystem. This focus will be further explored in future work.

Escherichia coli is the main pathogen responsible for extraintestinal infections. A total of 196 clinical E. coli consecutively isolated during 2016 in Spain (100 from Lucus Augusti hospital in Lugo) and France (96 from Beaujon hospital in Clichy) were characterized. Phylogroups, clonotypes, sequence types (STs), O:H serotypes, virulence factor (VF)-encoding genes and antibiotic resistance were determined. Approximately 10% of the infections were caused by ST131 isolates in both hospitals and approximately 60% of these infections were caused by isolates belonging to only 10 STs (ST10, ST12, ST58, ST69, ST73, ST88, ST95, ST127, ST131, ST141). ST88 isolates were frequent especially in Spain while ST141 isolates significantly predominated in France. The 23 ST131 isolates displayed four clonotypes: CH40-30, CH40-41, CH40-22 and CH40-298. Only 13 (6.6%) isolates were carriers of ESBL enzymes. However, 37.2% of the isolates were multidrug-resistant (MDR). Approximately 40% of the MDR isolates belonged to only four of the dominant clones (B2-CH40-30-ST131, B2-CH40-41-ST131, C-CH4-39-ST88 and D-CH35-27-ST69). Among the remaining MDR isolates two isolates belonged to B2-CH14-64-ST1193 i.e the new global emergent MDR clone. To our knowledge, it is the first identification of this emergent clone in Spain. Moreover, a hybrid ExPEC/enteroaggregative isolate belonging to A-CH11-54-ST10 clone was identified.

Whistler mode waves play a major role in regulating the lifetime of trapped electrons in the Earth's radiation belts. Specifically, whistler mode hiss waves are one of the mechanisms that maintains the slot region between the inner and outer radiation belts. The generation mechanism of hiss is a topic still under debate with at least three prominent theories present in the literature. Lightning generated whistlers in their ducted or non-ducted modes, are considered to be one of the possible sources of hiss. We present a study of new observations from the Radio Receiver Instrument (RRI) on the Enhanced Polar Outflow Probe (ePOP: currently known as SWARM-E). RRI consists of two orthogonal dipole antennas, which enables polarization measurements, when the satellite boresight is parallel to the geomagnetic field. Here we present 75 passes of ePOP - RRI from 2014 - 2018, in which lightning whistlers and hiss waves were observed. In more than 50% of those passes hiss is found to co-exist with the lightning whistlers. Moreover, the whistler observations are correlated with observations of wave power at the lower-hybrid resonance. The observations and a whistler mode ray-tracing study suggest that multiple-hop lightning induced whistlers can be a source of hiss and plasma instabilities in the magnetosphere.

Although the complexity of physically based models continues to increase, they still need to be calibrated. In recent years, there has been an increasing interest in using new satellite technologies and products with high resolution in model evaluations and decision-making. The aim of this study is to investigate the value of different remote sensing products and groundwater level measurements in the temporal calibration of a well-known hydrologic model i.e. HBV. This has been rarely done for conceptual models as satellite data are often used in spatial calibration of the distributed models. Three different soil moisture products from ESA CCI SM v04.4, AMSR-E and SMAP, and total water storage anomalies from GRACE are collected and spatially averaged over the Moselle River Basin in Germany and France. Different combinations of objective functions and search algorithms all targeting a good fit between observed and simulated streamflow, groundwater and soil moisture are used to analyse the contribution of each individual source of information. Firstly, the most important parameters are selected using sensitivity analysis and then, these parameters are included in a subsequent model calibration. The results of our multi-objective calibration reveal substantial contribution of remote sensing products to the lumped model calibration even if their spatially distributed information is lost during the spatial aggregation. Inclusion of new observations such as groundwater levels from wells and remotely sensed soil moisture to the calibration improves the model’s physical behaviour while it keeps a reasonable water balance that is the key objective of every hydrologic model.

The protection of electronics against environmental influences and mechanical loads is important for integration of conventional electronics in textile conductive tapes. For this purpose, the sensors on the tapes are molded with plastic locally. This process step is recognized in the injection molding process. The molding compound is then later selected depending on: The field of application, the parameters of the manufacturing process and the textile tape properties. We have designed a mould for liquid silicone (LSR) as well as for the textile and electronic insertions. The cavities are sealed by a local compression of the textile and the two inserts are positioned with position pins representing the main aspect of the mould design. The sampling tool and the process parameter optimization are mainly based on the material properties of the silicone and the mechanical sensitivity of the inserts. To reduce the deformation of the circuit boards by the melt front and ensuring the functionality of the electronics a low-pressure process is used.

The Rybczynski theorem describes the trade effect within production analyses between factor endowments and outputs. The Stolper-Samuelson theorem focuses on cost analyses between factor reward and commodity price. This paper examines the trade effect of changes of factor endowments on prices, based on general equilibrium. The study shows that changes of factor endowments cause domestic output changes (the Rybczynski effect), which affect output prices and factor prices (the Stolper-Samuelson effect). It is like a chain of effects that the Rybczynski’s trade effect triggers the Stolper-Samuelson’s trade effect. The analysis of this paper shows that a small increase of a factor endowment of any country rewards another factor and the commodity using the latter factor intensively. It displays a tuneful circle. Trade brings a well-balanced development to the world.

Functional ZnO nanostructured surfaces are important in a wide range of applications. Here we report facile fabrication of ZnO surface structures at near room temperature with morphology resembling that of sea urchins, with densely packed, μm-long, tapered nanoneedles radiating from the urchin centre. The ZnO urchin structures were successfully formed on several different substrates with high surface density and coverage, including silicon (Si), glass, polydimethylsiloxane (PDMS), and copper (Cu) sheets, as well as Si seeded with ZnO nanocrystals. Time-resolved SEM revealed growth kinetics of the ZnO nanostructures on Si, capturing the emergence of “infant” urchins at the early growth stage and subsequent progressive increase in the urchin nanoneedle length and density, whilst the spiky nanoneedle morphology was retained throughout the growth. ε-Zn(OH)₂ orthorhombic crystals were also observed alongside the urchins. The crystal structures of the nanostructures at different growth time were confirmed by synchrotron X-ray diffraction measurements. On seeded Si substrates, a two-stage growth mechanism was identified, with a primary growth step of vertically aligned ZnO nanoneedle arrays preceding the secondary growth of the urchins atop the nanoneedle array. The antibacterial, anti-reflective, and wetting functionality of the ZnO urchins—with spiky nanoneedles and at high surface density—on Si substrates was demonstrated. First, bacteria colonisation was found to be suppressed on the surface after 24 h incubation in Gram-negative E. coli culture, in contrast to control substrates (bare Si and Si sputtered with 20 nm ZnO thin film). Secondly, the ZnO urchin surface, exhibiting superhydrophilic property with a water contact angle ~0°, could be rendered superhydrophobic with a simple silanization step, characterised by a water static contact angle θ of 159° ± 1.4° and contact angle hysteresis ∆θ < 7°. The dynamic superhydrophobicity of the surface was demonstrated by bouncing-off of a falling 10 μL water droplet, with a contact time of 15.3 milliseconds (ms), captured using a high-speed camera. Thirdly, it was shown that the presence of dense spiky ZnO nanoneedles and urchins on the seeded Si substrate exhibited a reflectance R < 1% over the wavelength range λ = 200–800 nm. The ZnO urchins with unique morphology via a facile fabrication route at room temperature, readily implementable on different substrates, may be further exploited for multifunctional surfaces and product formulations.

Abstract Introduction: Antimicrobial resistance (AMR) is a recognised public health threat today globally. Though many active and passive stewardship strategies are employed to counter AMR clinically, educating school going children on AMR could be a futuristic cost-effective measure to minimize AMR development. We hypothesised NICE’s e-bug module to class VII school students on AMR determinants. Methodology: A prospective non-randomized intervention study on 327 students belonging to 9 schools of class VII around Manipal town, Udupi district, Karnataka state, India were included for the study. 10 questions on AMR determinants extracted from NICE’s e-bug program were quizzed in written as pre-test followed by an education intervention on the same questions followed by a post-test to end the session. Descriptive statistics to estimate epidemiological characteristics, Wilcoxon Signed Ranks and Kruskal-Wallis tests were applied to analyse statistical significance of pre/post-test performance scores for the 10 questions and between schools respectively Results: Students had inadequate knowledge on 7 AMR determinants (antimicrobial indication, its course, hand hygiene, fermentation, spread of infection, microbial multiplication and characteristics of microbe) when analysed for post-test performance (p<0.05). Comparison of post-test performance of 9 participating schools revealed statistical significance (p<0.05) for 3 questions (definition on antimicrobial, cover while cough/sneezing and microbial characteristics) Conclusion: Although students exhibited sub-optimal knowledge on few AMR determinants, they showed keenness to learn exhibited by their performance. Our findings and previous similar studies from Europe are suggestive of early pedagogic interventions on AMR through inclusion of such education modules in the curriculum could be potential tool for AMR prevention for future generations.

Electronic Nose (eNose) systems are particularly appreciated for their portability, usability, relative low cost and real-time or near real-time response. Their application finds space in several domains, including environmental monitoring. Within this field, marine monitoring is of particular scientific relevance due to the fragility of this specific environment, daily threatened by human activities that can potentially bring to catastrophic and irreversible consequences on marine wildlife. Under such considerations, a systematic review, complying with the PRISMA guidelines, was conducted covering the period up to October 15, 2018, in PubMed, ScienceDirect and Google Scholar. Despite the relatively low number of articles published on this specific topic and the heterogeneity of the technological approaches employed, the results obtained by the various groups highlight the positive contribution eNose has given and can provide in near future for the monitoring and safeguarding of this delicate environment.

Although there are extensive literature reports on the use of gold nanoparticle (AuNP) based homogeneous assays for detection of biomolecules, very few experimental description and procedures involving their preparation are described. In this study, AuNPs conjugated to Bovine Serum Albumin or Envelope protein from Dengue II were developed as a homogeneous immunoassay for antibody detection. We report here optimization of key parameters to prepare an immunoassay like conjugation protein concentration, centrifugation time, electrolyte addition and assay temperature. We determined that saturating protein concentrations improved AuNPs surface coverage and uniformity of the assay and addition of sodium chloride improved sensitivity of the antibody detection method and assay stability. Furthermore, we showed that dynamic light scattering can be used to monitor changes in gold nanoparticles in the preparation and detection steps. Additionally, numerical simulations of the plasmonic optical response of AuNPs were carried out to scan for size-dependent response of the AuNPs. The AuNPs homogeneous immunoassay developed was further used in the detection of antibodies in vitro to detect Dengue virus infection.

Accurate estimates of daily rainfall are essential for understanding and modeling the physical processes involved in the interaction between the land surface and the atmosphere. In this study, daily satellite soil moisture observations from the Advanced Microwave Scanning Radiometer - Earth Observing System (AMSR-E) generated by implementing the standard NASA- algorithm are employed for estimating rainfall, firstly, through the use of recently developed approach, SM2RAIN (Brocca et al., 2013) and, secondly, the nonlinear autoregressive network with exogenous inputs (NARX) neural modelling at five climate stations in the Karkheh river basin (KRB), located in southwest Iran. In the SM2RAIN method, the period 1 January 2003 to 31 December 2005 is used for the calibration of algorithm and the remaining 9 months from 1 January 2006 to 30 September 2006 is used for the validation of the rainfall estimates. In the NARX model, the full study period is split into a training (1 January 2003 to 31 September 2005) and a testing (1 September 2005 to 30 September 2006) stage. For the prediction of the rainfall as the desired target (output), relative soil moisture changes from AMSR-E and measured air temperature time series are chosen as exogenous (external) inputs in NARX. The quality of the estimated rainfall data is evaluated by comparing it with observed rainfall data at the five rain gauges in terms of the correlation coefficient R, the RMSE and the statistical bias. For the SM2RAIN method, R ranges between 0.44 and 0.9 for all stations, whereas for the NARX- model the values are generally slightly lower. Moreover, the values of the bias for each station indicate that although SM2RAIN is likely to underestimate large rainfall intensities, due to the known effect of soil moisture saturation, its biases are somewhat lower than those of NARX. In conclusion, the results of the present study show that with the use of AMSR-E soil moisture products in the physically based SM2RAIN- algorithm as well as in the NARX neural network, rainfall for poorly gauged regions can be fairly predicted.

Apoptosis and cell cycle arrest induction are targeted in the strategy of cancer therapy. Furthermore, bacterial toxin such as shiga-like toxin producing Escherichia coli has been suggested to be used as novel therapeutic agent against tumor malignancies either as independent anti-neoplastic agents or in combination treatment with chemo or radiotherapy. The aim of study was to investigate the potency of shiga-like toxin originated from local strains of E. coli O157:H7 as a new cancer therapy. As many as 10 culture cells T47D cell line were subjected by crude extract Shiga like toxin originated from five local isolates of E. coli O157:H7 i.e. KL-48(2), SM-25(1), SM-7(1), DS-21(4), and one isolate ATCC 43894 as a control with IC50 doses, respectively. The treatment was observed for 24 h, with two replications. An FITC-Annexin V and PI assay was used to observe apoptosis and necrosis effect, and simultaneously with cell cycle analysis using propidium iodide (PI) staining. Results of study showed T47D cell treated with Shiga-like toxin from local strain KL-48 (2) show the lowest viable cell, followed by SM 7(1), ATCC 43894, SM-25(1), DS-21(4) and contrary with control with each percentages as 15.20, 16.36, 22.17, 22.64, 33.86, and 94.36%, respectively. The results were also confirmed by the induction of the cell cycle arrest in phase G0-G1 as inactive phase, i.e. 66.41, 63.37, 61.52, 55.36 and 47.28% for T47D cell treated with toxin of KL-48(2), ATCC 43894, SM 25(1), SM 7(1), and DS 21(4), respectively. These results show tendency deleterious effect of Shiga-like toxin from local isolates on T47D cell, so that concluded they have potency as a good anticancer drug in Gb3-expressing breast cancer.

Electronic-health applications rely on large computer networks to facilitate patients' information access and to communicate various types of medical data. To examine the effectiveness of these networks, the traffic parameters need to be analysed. Due to quantity of the information carrying packets, examining each packet's transmission parameters individually is not practical, especially when a real time operation is needed. Sampling allows a subset of packets that accurately represents the original traffic to be formed. In this study an adaptive sampling method based on regression and fuzzy inference system was developed. It dynamically updates the number of packets sampled by responding to the traffic variations. Its performance was found to be superior to the conventional non-adaptive sampling methods.

Freeze drying (FD) is a technique used to preserve the bioactive content and flavor of samples. Foods with a short shelf life due to nature have been preserved by FD in recent years. The success of the drying technique is thanks to the high retention ability of the bioactive compounds and the flavor of the sample. However, the high cost and energy consumption of the FD limit its usage in several fields. Freezing, primary drying, and secondary drying, which take place in the same device, are the stages of the FD. In addition, several parameters, including pretreatment, size, temperature, sample species, time, and pressure, affect the FD process. These parameters are controlled to increase the effectiveness of the FD on the samples. Moreover, FD was compared with other drying techniques including hot-air drying, microwave drying, vacuum drying, and solar drying to determine its protective capability. It has also been applied to the valorization of waste products, which is a common problem worldwide. For valorization, microencapsulation and powder production have been achieved by FD. In recent years, studies on the effects and use of the FD on various materials increased, providing new aspects for the future of science and food industry.

The aim of this study was to evaluate soil properties and Eragrostis tef (teff) growth on Technosols produced from coarse and fine coal wastes from Moatize Mine, Mozambique. The experiment was performed in triplicate in 30 L containers filled with different substrate conditions, composed of fine coal waste, coarse coal waste, agricultural soil, and sewage sludge as an organic matter source. The soil analyses included bulk density, available water capacity, permeability, and fertility. Plant growth was monitored for biomass production and plant tissue composition. All the substrates presented a good available water capacity and a proper drainage condition. Regarding the soil fertility, there were shortages of potassium and boron in the substrates composed exclusively of coal wastes, which was reflected in the composition of the plant tissue. Even so, plant growth was statistically equivalent to the control in all conditions, except for the substrate produced exclusively with fine coal waste and sewage sludge, which presented a better performance. Technosols are an alternative for reducing the final mine waste volume, and Eragrostis tef used as a means for land use after the mining process, with social gains, and as a tool in an ecological process for restoring coal mining sites.

Considerable amounts of agro-industrial by-products are discarded or burnt as fuel every year. However, they can be utilized as a valuable source of fiber, phenolics and other useful compounds such as antioxidants. The profile of beneficial compounds can be affected by genotype, locality, orchard management and productive season, adding or decreasing the bioactive potential of by-products. In this study, hazelnut (Corylus avellana L.) and walnut (Juglans regia L.) nutshells were investigated for their fiber content and antioxidant capacity as valorized by-products for the industry. Determinations (ORAC, TPC and color asses) were performed in hazelnut and walnut orchards located in Southern Chile during three consecutive seasons (2020/21; 2021/22 and 2022/23). Analyses of oxygen radical absorbance capacity (ORAC) in nutshells showed the highest ORAC from both species in the season 2020/21 (3217 µmol TE g1DW for hazelnut shells and 4663 µmol TE g DW1 for walnut shells), while variability in the consecutive seasons was lower for hazelnut than in walnut. Total phenolic content in hazelnut shells was positively correlated with L* (R: 0.883) and E (R: 0.924) during 2020/21 season, also with L* for 2022/23 (R: 0.907). While ORAC was negatively correlated with L* (R: 0.922) in 2021/22. In addition, morphological and structural features of both nutshells examined by Scavenging Electron Microscopy (VP-SEM) and Confocal Scavenging Laser Microscopy (CSLM) revealed differential tissue distribution and accumulation patterns of both cellulose and lignin. On the other hand, photo-colorimetric values were determined for both shells and corresponding seasons, and non-significative differences were found both shells and among seasons Finally, these results provide insight into the physicochemical characteristics of two shell types which should be considered together with antioxidant capacity in their valorization as a residual material.

Medical waste management is crucial issues for keeping our life safe and safety. Without effective measures for waste management, we cannot keep ourselves safe from different types of contagious diseases; viruses, bacteria. Knowledge sharing assists healthcare staff in identifying and mitigating hazards on appropriate handling, segregation and disposal medical waste. The aim of the study is to identify a multifaceted analysis of knowledge sharing, training, communication and attitudes for effective medical waste management. This study selected 153 medical workers randomly, including nurses, lab technologists, and cleaners, from hospitals, diagnostic centers, and clinics in the northern part of Bangladesh. The study design of this research is mixed-methods. This research adopts a survey and interview as a research strategy. The samples are collected randomly. SPSS software packages, MS Excel Office, and PLS-SEM are used to analyze data. Most of the respondents always share their knowledge face-to-face according to the findings. The result also shows that there are positive relationship between sources of knowledge (p: 0.046), awareness and knowledge (p: 0.049), attitudes of waste management (p: 0.025) and effective medical waste management. However, there are no relationships between communication and collaboration (p: 0.943), the practice of waste management (p: 0.155), supervision and staff monitoring (p: 0.527), training and education (p: 0.656) and effective medical waste management. Its focus on the northern part of Bangladesh introduces regional specificity, potentially limiting the applicability of results to other regions. The knowledge-sharing practices for waste management among medical staff are examined within this research, along with the relationship between attitude, awareness, and knowledge, staff supervision and monitoring, practice, training, and education and effective medical waste management that have not been studied before home and abroad. This analysis highlights the critical need for an integrated approach to medical waste management, emphasizing the importance of continuous education, open communication, and cultivating a culture that prioritizes environmental sustainability. The insights from this study offer practical recommendations for healthcare institutions to improve their medical waste management practices, ultimately leading to enhanced health outcomes and better environmental protection.

Hazelnut shells (HS), scientifically known as Corylus avellana L. shells, are a waste produced in companies that process nuts. The main objective of this study was to find an efficient way to maximize the chemical potential of HS by solubilizing the hemicelluloses, which could then be used to recover sugars and at the same time increase the lignin content of this material in order to produce adhesives or high strength foams. In order to optimize the pre-hydrolysis process, two different temperatures (160 and 170 C) and times varying from 15 to 180 min were tested. All the remaining solid materials were then liquefied by polyalcohols with acid catalysis. The chemical composition of hazelnut shells was determined before and after the pre-hydrolysis. All the process was monitored by FTIR-ATR by determining the spectra of solids and liquids after pre-hydrolisis and liquefactions steps. The highest solubilization of hazelnut shells was found for 170 C and 180 min, resulting in a 25.8% solubilization. Chemical analysis after the hydrolysis process showed a gradual increase in the solubilization of hemicelluloses as both the temperature and time of the reactor were increased. Simultaneously, the percentages of α-cellulose and lignin in the material also increased with rises in temperature and duration. FTIR-ATR allowed for the detection of significant spectral changes in the hazelnut shells from their initial state to the solid residue and further into the liquefied phase. This confirmed that pre-hydrolysis was effective in enhancing the chemical composition of the material, making it more suitable for the production of adhesives or polyurethane foams with enhanced mechanical strength.

Involving industrial waste into economic circulation, in particular flotation waste from coal enrichment, is an urgent task. The coal preparation waste of ArcelorMittal Temirtau JSC was studied with a view to the possibility of using it as an alternative substitute for coke breeze in the sintering process. During a thermoanalytical study on a synchronous thermal analyzer STA 449 NETZSCH in dynamic mode with a heating rate of 10, 20, 30 °C/min in an air flow of 30 cm³/min in the temperature range 30–1000 °C, we determined the lower heat of combustion of carbon-containing material, change mass during calcination, change and rate of change in the mass of the sample, thermal effect of the process, the temperature of the beginning, end and maximum development of thermal effects. It has been established that the greatest mass loss is observed in the temperature range 580 °C- 610 °C, which is about 65–67% of the total mass of the organic component of coal. The maximum burnout rate corresponds to a temperature of 540–563 °C. The lowest calorific value of the studied waste was 15.9 MJ/kg. The results of thermal analytical research and technical analysis substantiate the possibility of using flotation waste in a mixture of up to 10% with coke breeze for combustion in the sintering layer for the production of sinter. Analysis of the composition of flotation waste showed that they have a high specific surface area (56.8∙10³ m²/kg), are highly dispersible, soggy, and capable of swelling, and the predominant amount of clay substance makes them a plastic material. The possibilities of using coal flotation waste as an alternative substitute for coke breeze have been studied after the regimes of its preparation for sintering have been developed and a rational regime of layer-by-layer combustion in the sintering layer has been established. The optimal ratio of coke and OPC in the fuel mixture of the sintering charge was determined.

In the ongoing work, environmentally sound technologies for converting organic wastes into fertilizers, to improve soil sustainability and crop yield have been identified and assessed. Wet wastes were combined with 50% wood sawdust and 50% 50% wet wastes (Compost 1) or (10% Straw + 90% wet wastes) (Compost 2) to produce soil improvers with a balanced level of nutrients and their effectiveness on soil ecosystem functioning have been tested and compared to horse manure (HM) and nitrogen:phosphorous:potassium (NPK) fertilizers. Unfertilized soil was used as control. Soil chemical and biological properties, have been detected after the harvesting of broccoli and red cabbage (90 days from the initial treatments). Three independent experiments have been conducted in open field in a randomized complete block design with three replications (n=9). Results showed that Compost 1 had the highest C/N ratio and CSC, indicating a better humification of wet material. Compost 1 even if contained a minor amount of organic carbon, as well as a less activity of FDA and DHA than Compost 2, was the most effective in improving soil quality, significantly increasing the labile fraction of organic matter, the oxidative enzyme (DHA), microbial biomass and crop yield. Both composts increased crop productivity.

This study aims to contribute to the characterization of Katangese Copperbelt's mining wastes and soils polluted with trace metals, using pollution indices and direct concentration measurements. The study also evaluated the use of these indices in assessing the success of remediation projects. Analytical data from previous studies and samples collected from six types of discharge and one polluted soil were used to address the first objective. Soil and plant samples were collected at Kipushi and Penga Penga for the second objective. The results revealed very high concentrations of As, Cd, Co, Cu, Mn, Pb, and Zn in all mine tailings and polluted soils, compared with local references. The degree of contamination (DC) values (from 72 to 5440) and potential ecological risk (RI) values (from 549 to 162 091) indicate very high-risk situations associated with polluted discharges and soils. Regarding revegetation trials, the results show lower concentrations and RIs in tree rhizospheres compared with unamended areas at both sites. However, trace metal concentrations are higher in tree rhizospheres compared with local references, and RI values are in the considerable risk range for Penga Penga (RI = 533) and very high (&gt;1500) for Kipushi. Bioconcentration factor values are below 1, indicating low accumulation in roots, wood, and leaves, and low risk of contamination of the trophic chain. In this context, it seems that the pollution indices used are unsuitable for assessing the effectiveness of phytotechnology processes based on metal stabilization. Direct plant performance measurements combined with direct measurements of metals in substrates and plants to assess transfer and efficiency are more appropriate.

This paper presents the results of investigations into the pyrolysis of waste polypropylene in a laboratory fixed-bed batch reactor. The experiments were designed and verified in such a way as to allow the application of the Response Surface Methodology (RSM) in the development of an empirical mathematical model that quantifies the impacts mentioned above. The influence of the mass of the raw material (50, 100 and 150 g), together with the reactor temperature (450, 475 and 500 °C) and the reaction time (45, 50 and 75 min) was examined. It has been shown that the mass of the raw material, i.e. the filling volume of the reactor, has a significant influence on the pyrolysis oil yield. This influence exceeds the influence of reactor temperature and reaction time. This was explained by observing the temperature change inside the reactor at three different spots at the bottom, middle and top of the reactor. Recorded temperature diagrams show that with greater masses of feedstock, local overheating occurs in the middle part of the reactor, which leads to overcracking of vapor products, and from there to an increased formation of non-condensable gases, i.e. reduced yield of pyrolytic oil.

Improper disposal of waste plastic has caused serious ecological and environmental pollution problems. Transforming plastics into high value-added chemicals can not only achieve efficient recycling of waste plastics, but also an effective way to control white pollution. The catalyst selectively breaks the C-C bond of polyolefin plastic under heat treatment and converts it into liquid fuel, thus realizing sustainable recycling of plastics and has a good development prospect. This review provides a detailed overview of the current development of catalytic pyrolysis, catalytic hydrolysis, solvent decomposition and supercritical hydrothermal liquefaction for cracking plastics to make fuel oil. The reaction mechanism, influencing factors and promoting effects of catalysts in various degradation technologies are analyzed and summarized and the latest proposed tandem reaction for degrading plastics is briefly introduced. Finally, some optimization paths of waste plastic pyrolysis to fuel oil technology are proposed: synergies between mixed raw materials, in-depth exploration of catalysts, design and manufacture of reactors that match the pyrolysis technology. All these are important research directions for promoting the industrialization of plastic pyrolysis to fuel oil.

Lavander distillation leads to huge quantities of solid waste produced yearly. This waste is usually discarded resulting in serious environmental issues. However, it still contains residual essential oil and other bioactive compounds. This research reports on the development and comparison of optimized solid-liquid separation methods, i.e. microwave (MAE) and ultrasound assisted extraction (UAE) of phenolic compounds from lavender distillation waste. Optimal pretreatment conditions, such as waste moisture content and particle size were also determined. The extracts were spray or freeze-dried and the resulting powders were characterized for their physicochemical properties. The majority of the original phenolic compounds in lavender were found in the leachate fraction after distillation (61%), while 43% in the solid waste. Drying of the solid waste before extraction affected the process efficiency. UAE led to higher phenolic content and antioxidant properties compared to MAE. Drying (spray or freeze) the extracts did not significantly affect their phenolic content, while the use of maltodextrin as a drying agent improved the drying process yield especially in the freeze-drying method. It is concluded that valorization of lavender distillation wastes can be achieved via an integrated process consisting of a green extraction method and a consequent drying process that result in a stable bioactive powder.

Onion skin waste (OSW), the primary non-edible byproduct from onion processing, offers a renewable source of bioactive compounds. This study aims to valorize OSW through subcritical water extraction (SWE), aligning with circular economy and biorefinery principles. SWE was carried out at 145 °C, 50 bar and 50 min in a discontinuous reactor, producing a phenolic-rich extract (32 ± 3 mg/g), dominated by protocatechuic acid (20 ± 3 mg/g), quercetin-4´-O-glucoside (7.5 ± 0.2 mg/g), and quercetin (3.2 ± 0.6 mg/g). Additionally, it contains sugars (207 ± 20 mg sucrose-Eq/g), proteins (22.8 ± 1.6 mg BSA-Eq/g) and free amino acids (20.4 ± 1.2 mg arginine-Eq/g). Its phenolic richness determines its scavenging activity against ●NO and O2●- radicals, and its α-glucosidase and aldose-reductase inhibition without affecting α-amylase. Notably, the extract demonstrates significant α-glucosidase inhibition (IC50 = 76 ± 4 µg/mL), surpassing acarbose (IC50 = 129.5 ± 1.0 µg/mL), in both pure enzyme and cell culture tests without showing cytotoxicity on AGS, HepG2 and Caco-2 human cell lines. The extract’s bioactivity and nutritional content make it suitable for developing antioxidant and antidiabetic nutraceutical/food components, highlighting the SWE potential for OSW valorization without using organic solvents.

Electronic waste (e-waste), characterized by the widespread disposal of electronic devices, shows a growing environmental challenge. In this study, we explore the electrocatalytic potential of gold nanoparticles supported on Vulcan obtained from e-waste for their application as electrocatalysts for the methanol oxidation reaction in alkaline media. Gold nanoparticles are synthesized from gold coatings recovered from Intel Pentium 4 processor pins, highlighting their sustainability as electrocatalyst precursors. Comprehensive characterization, including UV-Vis spectroscopy, transmission electron microscopy (TEM), scanning electron microscopy (SEM) and X-ray dif-fraction, is performed to assess the electrocatalyst's structural properties. Electrochemical evalu-ation is carried out in 0.5 M KOH electrolyte employing the rotating disk electrode technique, us-ing cyclic voltammetry for the study of methanol oxidation. Remarkably, the gold nanoparticles show electrocatalytic activity on par with commercially synthesized counterparts, demonstrating the feasibility of this approach for sustainable electrocatalyst production. Thus, this research opens new routes for utilizing e-waste as a source of valuable catalyst materials, addressing en-vironmental and technological challenges in the field of alkaline fuel cells.

This paper aims to propose improvements for plastic waste management in Salvador – the Brazilian third most populated metropolis – via Partial Least Squares Structural Equation Modeling (PLS-SEM). All indicators, constructs, and hypotheses regarding collection, sorting, recycling, and disposal in the proposed PLS model were derived from the literature review, and the dependence of the performance construct on efficiency, effectiveness, municipality's socioeconomic aspects and municipality infrastructure is evaluated. Academic and practitioner publics were surveyed, and after analysis in both SmartPLS and RStudio software, suggestions for improvement regarding plastics recycling rate, market maturity, and infrastructural aspects for optimized reverse logistics were made. Since almost double the minimum number of respondents answered the survey questionnaire and the PLS-SEM statistics showed that the modeling presents consistency, the discussion is relevant. The model can and will evolve, but examples of suggested improvement are the installation of Deposit-Return Systems (DRS) in parks, streets, and avenues for increasing selective collection and the direct purchasing of waste from residents by municipal administration, compensating them with vouchers for food. The model can be a basis for other cities worldwide sharing analogous characteristics. By considering it, organizations can contribute to both reduced Greenhouse Gas (GHG) emissions and reduced terrestrial pollution.

Aquaculture by-products can be compromised an important liming material of increasing soil pH and soil fertility. The aim of this research was to assess the effect of mussel shells on soil pH, on organic matter and on soil nutrients. In this study a pot experiment was carried out at the De-partment of Ichthyology and Aquatic Environment (University of Thessaly, Greece). A acidic soil (pH 4.26) amended with 6 different proportions of mussel shell (0.0, 0.1, 0.3, 0.5, 1, 3 and 6%) in two different grain sizes (Fine powder (>1 mm) and Coarse powder (1-2 mm)), resulting in 13 treatments. According to the results, it was observed that pH, organic matter, Available P and Exchangeable K increased. Specifically, the highest pH values observed at 6% rate. Available P and Exchangeable K achieved the highest content at 6% Fine powder treatment, 46.2 and 190.1 mg kg-1, respectively. Similarly, organic matter had the highest value in 6% Fine powder pots (2.27%). Moreover, Total N concentration varied from 0.11 to 0.14 but no statistically significant different was noticed between the treatments. In conclusion, mussel shells can compose a promising liming material in the agriculture section.

Colombia is the world's leading producer of mild washed arabica coffee and produces 12.6 million bags of green coffee, but at the same time 784,000 tons of waste biomass are dumped in open fields, of which only 5% is recovered or used. The objective of this project was to evaluate the production of platform chemicals from these coffee wastes. To achieve this, biomass characterization was carried out using proximate analysis, ultimate analysis and structural analysis. Hydrothermal valorization was carried out at a temperature range of 120-180 °C (LHW) and 180-260 °C (HTC) for one hour, the platform chemicals obtained were quantified by HPLC-IR, monitored by pH and conductivity, and the solid fraction was characterized by monitoring the functional groups in IR spectroscopy, and elemental analysis. Hydrolysis processes were obtained from 150 °C, production of platform chemicals from 180 °C and maximum concentration at 180 °C-4h, over 200 °C degradation of the products in the liquid fraction starts to take place. Homogeneous basic and acid catalysts were used to improve the yields of the reaction. The kinetics of the hydrolysis of lignocellulosic structures to sugars were also analyzed and described, and reaction orders of 1 (LHW), 3 (HTC) and their respective reaction rate equations were reported.

In this study, the objective is to analyze the economic viability of municipal household solid waste (organic matter + paper) for the production of gas, coke and biofuel through the pyrolysis and distillation process. The waste was collected in the city of Belém do Pará-Brazil and pre-treated at UFPA. The analyzed fraction (organic matter + paper) was subjected to pre-treatment of drying, crushing, sieving and was subsequently subjected to proximate characterization and finally pyrolysis of the organic fraction (organic matter + paper) in a fixed bed reactor. Initially, it was necessary to review the literature and with the yields obtained by pyrolysis of the frac-tion, economic feasibility analyzes were carried out. The economic indicators for evaluating the most viable pyrolysis process were: simple payback, discounted payback, net present value (NPV), internal rate of return (IRR), and profitability index (IL). The analysis of the indicators showed the economic viability considering an analysis horizon of 10 years, of materials based on organic material and paper. The break-even point obtained was 0.96 US$/L and the minimum biofuel sales price (MFSP – “Minimum Fuel Sale Price”) obtained in this work was 1.30 US$/L. The sensitivity analysis demonstrated that material costs (organic matter + paper), bio-oil yield, total project investment and electricity, respectively, are the variables that most affect the mini-mum biofuel sales price (MFSP).

In recent years, the use of solid waste fillers to partially replace natural fillers in asphalt mixtures to produce high-performance asphalt mixtures has received widespread attention. However, differences in the material properties of solid waste fillers remain a problem for this recycling method. To address this issue, limestone powder in asphalt mixtures was replaced by three solid waste fillers (steel slag powder, tailings powder and calcium carbide slag powder) in this study. The chemical composition of the fillers was first characterized to assess the homogeneity of the material. Then, AC and SMA asphalt mixtures were designed and produced and characterized for wet stability. The results showed that asphalt mixtures with solid waste fillers were superior to LP asphalt mixtures in terms of resistance to water damage, and steel slag powder showed the best improvement in moisture stability of asphalt mixtures. The optimum substitution of solid waste filler for limestone filler was 25%. In addition, the moisture stability of asphalt mixture with limestone filler was significantly improved with the addition of anti-stripping agents. In contrast, the moisture stability of asphalt mixtures with solid waste filler was slightly improved. Solid waste fillers could be used in asphalt mixtures and have a similar function as the anti-stripping agent. In summary, the use of solid waste fillers to replace mineral fillers in asphalt mixtures is a reliable, value-added, recycling option.

Thermoelectric (TE) waste heat recovery has attracted significant attention over the past decades, owing to its direct heat-to-electricity conversion capability and reliable operation. However, methods of system-level TE design optimization for specific application systems have not been thoroughly investigated. This work theoretically studies the performance optimization and exergy analysis of TE systems for recovering waste heat from the exhaust ducts of a gas turbine power plant. A numerical tool has been developed to solve the coupled charge and heat current equations with temperature-dependent material properties and convective heat transfer at the interfaces. Our calculations show that at the optimum design with 50 % fill factor and 6-mm leg thickness made of state-of-the-art Bi2Te3 alloys, the proposed system can reach power output of 10.5 kW for the TE system attached on a 2 m-long, 0.5 x 0.5 m2-area exhaust duct with system efficiency of 5 % and material cost per power of 0.23 $/W. Moreover, our extensive exergy analysis reveals that only 1 % of the exergy content of the exhaust gas is exploited in this heat recovery process and the exergy efficiency of the TE system can reach 8 % with improvement potential of 85 %.

This paper presents the results of investigations on the pyrolysis of tyres waste in a laboratory fixed bed batch reactor. The results regarding the influence of either the reaction temperature (425, 450, 475, and 500 °C) and the flow of the inert gas (0, 100, 300, and 500 mL/min) on products yield (referred to pyrolysis of waste tyres) are also considered and discussed. On the basis of the above mentioned findings, the most appropriate experimental conditions were selected to contribute to a higher yield of pyrolysis oil. The sample of pyrolysis oil obtained from the experiments carried out in the selected optimal conditions (reaction time 120 min, temperature 450 °C and the inert gas flow of 100 mL/min) was subjected to a calorimetric and infrared spectroscopy analysis. The results of IR spectroscopy analysis on this oil sample showed the following content in percentages (by mass): 32.59 % of aromatics, 51.06 % of paraffins and 16.35 % of naphthenes. The pyrolysis oil so obtained has a high calorific value (42 MJ/kg) and a low sulfur content (0.41 % by mass), which makes it an excellent raw material for energy production. The solid product, i.e. pyrolysis char or carbon black, has the potential to be used as an adsorbent or catalyst support after an activation process, which changes its irregular pore structure to a more voluminous one, making the overall structure more crystalline and symmetrical. Pyrolysis coal has a fairly high calorific value of 31 MJ/kg, when compared to typical solid fuels, so it can be used in energy production or as a feedstock for the gasification process.

The phosphogypsum (PG) pile of solid waste is of immense proportions and poses a grave threat to the ecological environment, with its reserves steadily increasing year after year. The urgent need for large-scale consumption and high-quality utilization of PG in industrial production has become apparent. The present study provides a comprehensive analysis of the correlation be-tween the macroscopic mechanical properties and microstructure of PG, elucidating the crystal morphology characteristics in different phases and outlining the crystallization preparation pro-cess. By integrating the physical and chemical properties of diverse PG phases with the intricacies associated with its preparation process, it is imperative to explore avenues for its high-value utili-zation, investigate possibilities for industrial-scale production, and analyze and predict the appli-cation trends and developmental directions in comprehensive PG utilization. These endeavors hold immense significance in guiding the realization of resource utilization potential inherent in PG.

Amidst the strong demand for wood-based products, and the clamor of environmental consciousness, more functional and green solutions arise to meet both of these goals. Pursuant to this, the study looked into the potential of a bio-waste taken from Cocos nucifera tree known as phellem—the tree’s outermost skin made of dead tissues, to be a main component of a new construction material. This study builds on existing research showing phellem is impermeable, buoyant, elastic, has a slow burn rate, and repels water during precipitation, which supports the hypothesis that phellem may be a potential substitute material for dry wall boards. To test this, three (3) formulations were developed as experimental setups to test the physico-mechanical properties of coconut palm phellem (COPAP): Formulation A (40% COPAP and 60% cement); Formulation B ( 25% COPAP and 75% cement); and lastly, Formulation C that was (10% COPAP and 90% cement). The study tested (1) which among these formulations exhibited the best physico-mechanical properties, then it (2) compared the formulations with common dry wall products available in the market, and subsequently, (3) identified the possible architectural applications of COPAP board as a new building material. Of the three setups, Formulation C exhibited the best physico-mechanical properties in terms of compressive and flexural strength, fire resistivity, and water absorption. It fared better than the particle board in terms of compressive strength, better than wafer and particle board in fire resistivity, performed best in the water absorption test, and was almost equivalent in flexural strength to fiber cement board. With these findings, the study concluded that COPAP board can be used for projects that entail a high number of interior partitions, such as offices, BPO firms and commercial stalls in shopping malls, etc. The findings were conclusive only for interior applications, as the results clearly suggest that the COPAP boards are not load-bearing. Future investigations may explore and assess other properties of COPAP boards like thermal and sound insulation, resistance to rot and other properties that may prove its competitive advantage as a construction material.

Due to the growing demand for Medicinal and Aromatic Plants (PAMs), environmental risks associated with overexploitation and inadequate waste management are increasing. Since MAPs residues have a notable potential to be valorised, the implementation of Circular Economy solutions can play a central role in transforming waste management problems into economic opportunities and in responding to the growing demand for MAPs. Circular economy is viewed as a solution for fostering a sustainable system planet and positively contributes to the economy and society. A systematic review was conducted aiming to identify potential applications for the valorisation of MAP, under a sustainable waste management and circular economy approach. A total number of 47 studies were analysed and it was verified that MAPs residues can be valorised for energy purposes, crop management and applications in chemical, food, pharmaceutical, cosmetic industries, among others. Despite the wide range of possible applications, to promote a progressive implementation of circular economy strategies by the industry, further investigation is needed regarding the development of more efficient techniques and technology to develop value-added products and the assessment of sustainable performance in empirical investigations, considering both economic and environmental indicators.

Currently, the design of the concrete mix is an important part of the environmental problem. In front of this question, engineers face a major challenge that is addressed in two ways. On one hand, how do they use its component materials to improve its mechanical properties, on the other hand how do they use less polluting materials? Hence, in an environmental and economical view, laboratory tests were carried out on samples of concrete reinforced with smooth steel fiber extracted from the waste tires, in order to assess its impact and to prove its mechanical feasibility for these purposes. Consequently, laboratory results have shown satisfactory improvement in the behavior of concrete under compression loads in the elastic stage and an increase in ductility and toughness of the matrix in the plastic stage. Besides, taking into account the discontinuity and the structural disturbances observed during the loading of samples in the post-elastic state, a method has been proposed to calculate "the effective toughness and toughness Index of fiber concrete; on the other hand, this method has helped to better optimize length and slenderness of fibers for better use of this recycled material

The pandemic of Covid-19 has contributed to the increase of the number of cases of anxiety, depression, and stress, especially in vulnerable workers. The objective of this study was to analyze factors associated with mental health of waste pickers and street sweepers in Brasília, Brazil, during the Covid-19 pandemic. It was a cross-sectional cohort study with a quantitative approach. SRQ-20 test was used to assess mental health. The study sample included 886 workers: 601 street sweepers and 285 waste pickers. Of the total, 71 workers (8.0%) had SRQ-20 ≥ 7, which is equivalent to adverse mental health. The characteristics associated with adverse mental health were women (PR: 3.36; 95%CI:1.86;6.08), worker between 18-39 years old (PR: 2.19; 95% CI 1.32;3.65), waste pickers (PR: 1.65; 95%CI:1.01;2.70), worker who reported two (PR: 3.24; 95%CI:1.72; 6.12), three or more (PR: 4.73; 95%CI:2.40;9.32) health problems. For the symptoms, 17.05% of the people interviewed said they felt sad and 18.25% nervous, tense, and worried. Female waste pickers, young adults, with many health problems were more susceptible to adverse mental health and it doesn't just affect them, but also their families. Public policies are needed to protect these professionals so that they can work safely and establish early interventions to maintain these workers' mental integrity.

According to circular economy principles, the recycling and reuse of waste tyre rubber is one of the most advanced and ecological waste disposal technologies. Each year about 19 million tons of tyres are produced, and this amount is increasing each year. One of the most innovative ways to recycle rubber waste is devulcanization. There are many methods of rubber devulcanization, but the most popular are grinding and chemical. In this article devulcanized rubber granules were used for the preparation of rubber samples. Two of them were obtained by the grinding method and one by chemical devulcanization. 15 different rubber samples were produced for the experimental measurements. Multilayer constructions with two solid layers of plasterboard on both sides (GKB and GKFI) and porous acoustic material of rubber sample inside were produced. Measurements were made in an impedance tube and compared with the results of TMM analysis. The same trends of resonant frequencies were determined. According to the results, the resonant frequencies depended on the thickness of the material, since transmission loss values depended on the mass of construction. According to the test results of transmission loss, constructions with 50mm thick rubber samples had on average 3dB better results than the structures with 25mm samples and 5dB better results than structures with 12 mm thick rubber samples. In addition, it was found that higher density plasterboards (GKFI) increased the overall transmission loss value of the structure by 5 dB. The same trends were determined by the TMM method. The test results showed that multi-layered constructions with devulcanized waste rubber had high transmission loss result and could be used for sound insulating structures.

Climate change is one of the main issues that humanity is currently facing due to carbon dioxide emissions caused by the use of fossil fuels. Organic Rankine cycles may play an important role in reducing these emissions since they can be operated by using industrial waste heat of renewable energies. The present study presents a comprehensive bibliographic review of organic Rankine cycles. The study not only actualizes previous reviews that mainly focused on basic cycles operating on subcritical or supercritical conditions but also includes the analysis of novel cycles such as two-stage and hybrid cycles and the used fluids. Recuperative and regenerative cycles are more efficient than reheated and basic single-stage cycles. The use of two-stage cycles makes it possible to achieve higher thermal efficiencies and net power outputs of up to 20% and 44%, respectively, compared with those obtained with single-stage cycles. Theoretical studies show that hybrid systems, including Brayton and organic Rankine cycles, are the most efficient; however, they require very high temperatures to operate. Most organic Rankine cycle plants produce net power outputs from 1 kW up to several tens of kW, mainly using microturbines and plate heat exchangers.

A field experiment was conducted on the farm of Abi Jarash in Agricultural Collage, different rates of olive solid waste and cow manure were used, as follows: (control, fresh olive solid waste 100%, fresh olive solid waste 75%+ cow manure 25%, fresh olive solid waste 50%+ cow manure 50%, fresh olive solid waste 25+ cow manure 75%, Fermented Olive Solid Waste 100%, Fermented olive solid waste 75%+ cow manure 25%, Fermented olive solid waste 50%+ cow manure 50%, Fermented olive solid waste 25+ cow manure 75%), wheat was seeded. The impact of fresh and fermented olive solid waste and cow manure on some chemical and fertility soil properties was studied. the olive solid waste treatment 100% which added had more effect on the organic matter, exchange capacity, nitrogen, phosphorus and potassium in soil, plant and productivity, after that the fermented olive solid waste 75% + cow manure, fresh olive solid waste 100% comparing with the control, the values of organic matter were (25% 2.73, 2.39) and the cation exchange capacity (21.76, 20.44, 19.38) and for phosphorus (303.3, 277.8, 171.8) mg / kg, while the values of potassium ​​were (303.3, 277.8, 171.8) mg / kg. In terms of plant content, the plant content of nitrogen, phosphorus and potassium were the same as for grains (2.784, 2.606, 2.126), (0.4535, 0.4226, 0.2753), (1.876, 1.762, 1.234) respectively, (0.2875, 0.2016) respectively for the same previous treatments and elements. olive solid waste 100% was the highest productivity comparing with the other treatments, where the productivity of wheat was (9.513) ton. ha-1.

This paper presents the life cycle assessment results of a study of plastic recycling via hydrothermal upgrading (HTU), a chemical recycling technology. It was investigated due to its potential to address current gaps in the plastic recycling system, largely due to several plastic packaging materials and formats that cannot be processed by traditional mechanical recycling technologies (primarily due to technoeconomic reasons). As society transitions towards a net-zero-based circular economy, assessments should be conducted with a futuristic outlook, preventing costly mistakes by employing the right technologies in the right areas. HTU can generate up to 76% reduction in climate change impacts when compared with comparable end-of-life treatment technologies whilst conserving material with the system. Additionally, further reductions could be achieved by changes in electricity consumption within the study. This represents a new insight to chemical recycling of polymers by establishing a prospective life cycle assessment study that looks to introduce a step-change in the recycling system. By creating a transparent cut-off model with consistent allocation, it highlights the benefits of introducing this technology as opposed to the current model of disposal through incineration or landfill.

Food waste is one of the greatest challenge to sustainability in developed and developing countries. In the former, food waste is concentrated in the final part of the chain. Too Good To Go is a digital platform aimed to prevent food waste, where consumers can buy magic boxes from different outlets containing food products that are approaching their end-of-life. However, the mechanism of the platform enable the outlets to publish their offering much in advance of the pick-up time, raising the question whether the food sold on the platform is effectively a leftover or a planned production. Our empirical study gathers data from over 1200 outlets in Rome on the Too Good To Go platform.

Municipal solid waste management is a major concern for developing countries all over the world. The collection and transportation accounts for major portion of expenditure in developing country like India. The compaction of waste is being practiced in some major cities of India as they provide economical benefit but the environmental benefits of compaction are not very clear. The preset study evaluates the environmental impacts due to transportation of non-compacted and compacted waste from the transfer station to the landfill site using life cycle assessment approach. The study compared transportation of non-compacted waste with the waste compacted by the truck mounted refuse compactor and portable stationary compactor. The functional unit defined was the amount of waste generated per day in the study area taken as Patna city and GaBi 10.5 used for impact assessment. The study found that the transportation of waste compacted by truck mounted refuse compactor had the least environmental impacts on all impact categories. The study recommends the compaction of waste by the truck mounted refuse compactor and then proceed for transportation. Also, the compaction of waste is recommended as it improve the overall environment performance of municipal solid waste management.

A renewable cyclic monoterpene obtained from citrus peel, limonene is widely used as a fra-grance, nutraceutical ingredient, antibacterial, biopesticide, and green extraction solvent. Indus-trial demand largely exceeds supply. After reviewing recent advances in the recovery of limonene from citrus peel and residues with a particular attention to benign-by-design extractive processes, we focus on the latest results in its dehydrogenation to p-cymene via heterogeneous catalysis.

The city of Lisbon, has any other capital of a European country, has a large number of issues while managing the waste and recycling containers spread throughout the city. This document presents the results of a study promoted by the Lisbon City Council for trialing LPWAN technology on the waste management vertical under the Lisbon Smart City initiative. Current waste management is done using GSM sensors, and the aim is to use LPWAN to reduce the costs, improve range and reduce provisioning times when changing the communications provider. After an initial study, LoRa was selected as the LPWAN of choice for the trials. The study is composed of multiple use cases at different distances, types of recycling waste containers, placements (underground and surface) and different kinds of waste level measurement LoRa sensors, deployed in order to assess the impact of the different use cases on the LoRa sensor usage. The results shown that the underground waste containers present the most difficult challenge, where the container itself imposes attenuation levels of 26dB on the link budget. The results promoted the deployment of a city wide LoRa network available to all departments inside the Lisbon City Council, and considering the network capacity the network, the network is also available to citizens to be used freely.

Growing evidence about the negative socio-environmental consequences of plastic pollution led to various initiatives for better plastic scrap governance and its trade. At the same time, an examination of recent data shows that plastic scrap represents only a fraction of recyclable materials which are traded internationally and are also subject to similar problems of cross-border environmental governance. A limited analysis comparing plastics, textiles, paper and ferrous metals suggests that ongoing momentum for improvement of plastic scrap governance and circularity should also be framed to consider other types of secondary materiais.

This work is aimed at the development of innovative, easy and cheap methods for the stabilization, inertization and valorisation of the organic fraction of municipal solid waste (OFMSW). For the first time, two original processes for transforming the organic waste into an inert, odorless and sanitized material were here proposed. The first one, called dual step, starts with grinding of the OFMSW, by means of an industrial shredder. After being finely ground, the organic waste was exposed to a sterilization process by means of UV/ozone radiations or thermal treatment (stabilization phase) in order to obtain a complete removal of the OFMSW’s bacterial activity. By means of several microbiological analyses, the best sterilization method was chosen. The incorporation in a thermosetting matrix was, then, carried out through mixing the sterilized and finely ground organic waste into a water soluble urea formaldehyde (UF) based resin, with a formaldehyde content less than 1% wt, followed by a thermal treatment for UF-resin crosslinking (inertization phase). An alternative cheaper and easier process, called one step, was also proposed and investigated, by combining the sterilization with the curing thermal process (at higher temperature) of the thermosetting matrix. The preliminary experimental results reported in this paper suggest that both the proposed methods could be considered suitable for the production of high valorized innovative OFMSW-derived panels or bricks, that could find application in several fields, such as building or constructions materials. Finally a brief description of the prototype machinery is reported properly designed for implementing OFMSW stabilization and valorisation processes developed in this research work.

Globally, public acceptance of waste-to-energy (WtE) incinerators is a crucial factor in implementing national waste-to-energy policies. This study adds to the literature on anti-incinerator sentiment by drawing upon an extended psychological-emotional model that integrates place-, trust-, and fairness-based pathways. A total of 338 residents in the Asuwei area in North Beijing completed a survey on a proposal to construct a WtE incinerator in the vicinity. Hierarchical regression analyses indicate that place attachment positively enhances anti-incinerator sentiment through direct effects, as well as through moderation and mediation effects between risk perception and opposing willingness. Further, institutional trust negatively moderates the impact of perceived risk on anti-incinerator sentiment, in addition to directly reducing perceived risk. Trust also influences anti-incinerator sentiment via risk perception, attesting to the effectiveness of a casual model of trust. Likewise, fairness perception acts as another determinant of opposing sentiment, similar to trust. We further reveal that procedural fairness plays a more significant role in predicting anti-incinerator sentiment than does distributional fairness. These findings demonstrate the importance of using a range of instrumental and more affective strategies to promote social acceptance of renewable energy infrastructure.

Milling and mining metal ores are major sources of heavy metal contamination. The Spring River and its tributaries in southeast Kansas are contaminated with Pb, Zn, and Cd as a result of 120 years of mining activities. Trace metal transformations and cycling in mine waste materials greatly influence their mobility and toxicity and affect plant productivity and human health. It has been hypothesized that under reduced conditions in sulfate-rich environments, these metals can be transformed into their sulfide forms, thus limiting mobility and toxicity. We studied biogeochemical transformations of Pb, Zn and Cd in flooded subsurface mine waste materials, natural or treated with organic carbon (OC) and/or sulfur (S), by combining advanced microbiological and X-ray spectroscopic techniques to determine the effects of treatments on the microbial community structure and identify the dominant functional genes involved in the biogeochemical transformations, especially metal sulfide formation over time. Samples collected from medium-, and long-term submerged columns were used for microarray analysis via functional gene array (GeoChip 4.2). The total number of detected gene abundance decreased under long-term submergence, but major functional genes abundance was enhanced with OC plus S treatment. The microbial community exhibited a substantial change in structure in response to OC and S addition. Sulfur-reducing bacteria genes dsrA/B were identified as key players in metal sulfide formation via dissimilatory sulfate reduction. Uniqueness of this study is that microbial analyses presented here in details are in agreements with molecular-scale synchrotron-based X-ray data supporting that OC-plus-S treatment would be a promising strategy for reducing metal toxicity in mine waste materials.

The cruise ship industry has become a well-implemented industry in the Baltic Sea area, and each year, the number of cruise ship passengers rises steadily. Efficient waste management in cruising ports around the Baltic Sea is a crucial element in minimizing environmental impacts. This research involves the four selected ports of Copenhagen, Helsinki, Stockholm and Tallinn. The study applies statistics and interview data to the analysis of waste management systems for cruise ship-generated waste. The interview data involves 14 executives and professionals responsible for environmental issues and decision making in their respective ports. The interviews highlighted the need for standardized environmental legislation and related procedures, which would result in coherent measurement systems. These systems would enable transparent environmental monitoring, thus maintaining the ports’ competitiveness. A common environmental legislation would support the emerging waste management system for the whole Baltic Sea area. We suggest that ports should focus on handling specific types of wastes and collaborate as a spatial network. Specialization to allow discharge of certain fractions of waste is essential. The paper concludes by addressing demands for future research, particularly vessel- and customer behavior focused studies.

Households and businesses are generating unprecedented levels of electrical and electronic wastes (e-waste), fueled by modernisation and rapid obsolescence. While the challenges imposed by e-waste are similar everywhere in the world, disparities in progress to deal with it exists; with developing nations such as South Africa lagging. The increase in e-waste generation increases the need to formulate strategies to manage it. This paper presents an overview of e-waste management on a global and South African scenarios with a specific case for Cathode Ray Tube (CRT) waste management practices in South Africa. CRTs present the biggest problem for recyclers and policy makers because they contain hazardous elements such as lead and antimony. Common disposal practices have been either landfilling or incineration. The research into the South African practices with regards to CRT waste management showed that there is still more to be done to effectively manage this waste stream. This is despite clear waste regulatory frameworks in the country. However, recent developments have placed e-waste as a priority waste stream, which should lead to intensified efforts in dealing with it. Overall, these efforts should aim to maximise diversion from landfilling and to create value-addition opportunities, leading to social and environmental benefits.

In road construction, before applying an asphalt or concrete surface, the ground must be compacted and stabilized. There are two basic methods of soil stabilization: in situ and in a stationary node (ex-situ). The method of performing stabilization in place (in-situ) is the most frequently used method due to its convenience and lower price. The most popular type of binder for stabilization is a hydraulic binder (most often cement and various ashes). Such stabilization is performed at a depth of 10-50 cm, achieving the desired load-bearing parameters. In order to improve them, various chemical additives for stabilization are often used, such as ion exchange compounds, additives based on sulfuric acid, additives based on vinyl polymers or even organic additives using lignosulfonates. However, the use of such additives is associated with much greater costs and environmental burden, resulting in seeking for cheaper and equally effective alternatives. The win-win situation would be for instance recycling the problematic waste-based materials that on one hand are landfilled or impossible to recycle and on the other hand cause problems for the waste producers. Therefore, an interesting issue is the production of stabilization additives from various types of waste materials. As a result of the extensive testing of various waste-based materials blends with soil, the mechanical (compressive strength after 7 and 28 days) and hydraulic (capillary rise, water absorption, frost resistance) soil properties were measured. The optimization process led to obtaining additives compositions ensuring the best strengthening and sealing properties. These were for sandy soil: Pure foil (wax emulsion), Pure foil (wax emulsion) + waste sulphuric acid, RDF from waste tires (wax emulsion), Pure foil (wax emulsion) + “by-pass” waste ash + NaOHx2 and for clayey soil: Pure foil (wax emulsion) + NaOH, Pure foil (wax emulsion) + waste sulphuric acid, Tequant, Pure foil (wax emulsion).

Cell membrane-derived liposomes, termed Memposomes, serve as promising carriers for drug delivery due to their ability to closely mimic cells and efficiently target specific cells. Liposomes derived from cancer cell membranes, in particular, exhibit homologous targeting capabilities, making them potential candidates for cancer-specific drug delivery. However, the underlying mechanisms and specific proteins responsible for this homologous targeting phenomenon remain debated. This study focuses on the role of E-cadherin, a cell adhesion molecule implicated in homophilic adhesion, in influencing the homologous targeting ability of Memposomes derived from cancer cell membranes. E-cadherin expression patterns were assessed in various cell lines, categorizing them into E-cadherin-positive and -negative groups. Memposomes were produced for each group, and their targeting tendencies were evaluated. The study confirmed that E-cadherin expression significantly influenced the homologous targeting ability of Memposomes. Cell lines with higher E-cadherin expression levels exhibited a more pronounced homologous targeting effect. This research demonstrates that cell adhesion molecules, particularly E-cadherin involved in homophilic adhesion, play a pivotal role in influencing the cell targeting ability of Memposomes. The study further validates the stability, safety, and purity of Memposomes, emphasizing their potential as effective drug delivery vehicles for the development of cell-specific therapies.

This qualitative study explores the pivotal roles of trust and communication in supplier relationship management (SRM) within the e-commerce sector. Drawing on interviews and thematic analysis, the study examines how trust, comprising dimensions of competence, benevolence, integrity, and reliability, underpins collaborative partnerships and operational resilience between e-commerce platforms and suppliers. Effective communication strategies, including proactive engagement, transparent feedback mechanisms, and real-time updates via digital platforms, are identified as critical enablers for enhancing information exchange and fostering mutual understanding in SRM. Challenges such as cultural differences, technological complexities, and regulatory compliance requirements are also discussed, highlighting the need for strategic management and investment to mitigate risks and maintain trust in supplier engagements. Relational competencies such as empathy, active listening, conflict resolution, and trust-building skills are recognized as essential for navigating interpersonal dynamics and fostering collaborative relationships in e-commerce SRM. Strategically, integrating these findings into comprehensive SRM frameworks is emphasized to cultivate a positive organizational culture characterized by openness, ethical integrity, collaboration, and adaptability. This approach aims to enhance supplier relationships, drive innovation, and achieve sustainable growth in a competitive marketplace.

Supplier diversity has emerged as a critical strategy for enhancing e-commerce operations by fostering inclusivity and innovation within supply chains. This qualitative research explores the role of supplier diversity in e-commerce, examining its impact on organizational strategies, competitive advantage, and stakeholder perceptions. Through semi-structured interviews with procurement managers, diversity officers, and supply chain executives from diverse e-commerce platforms, this study identifies key themes related to the benefits, challenges, and strategic implications of supplier diversity initiatives. Findings indicate that supplier diversity significantly enhances innovation and creativity within supply chains by integrating diverse perspectives and expertise. This diversity not only enriches product development and market responsiveness but also strengthens corporate reputation and brand equity, demonstrating organizational commitment to ethical business practices and community engagement. However, the study reveals persistent challenges, including financial barriers, systemic biases, and scalability issues, which hinder the effective implementation and scalability of supplier diversity programs. Effective supplier relationship management emerges as critical for maximizing the benefits of supplier diversity, fostering trust, collaboration, and long-term partnerships with diverse suppliers. Looking forward, the future of supplier diversity lies in digital transformation, globalization of supplier networks, and integration of sustainable sourcing practices to enhance transparency, efficiency, and resilience in supply chain operations. This study contributes to the growing literature on supplier diversity by providing empirical insights and practical implications for organizations aiming to leverage diversity as a strategic asset in e-commerce and global supply chain management.

With the burgeoning growth of online retail, the issue of counterfeit products has become a significant threat to both consumer trust and brand integrity, posing challenges to sustainable market practices. Online retail platforms are promoted to redesign their channel structures and enhance brand traceability to tackle counterfeits using blockchain technology. To investigate the interactions between blockchain technology and the channel structures of online retail platforms, we design a game theory model incorporating a manufacturer with(out) blockchain participation selling products via an online retail platform that operates an agency channel and/or a reselling channel. We show that the critical trade-off of blockchain participation comprises the brand assurance effect of the blockchain, the channel competition intensification effect, and the blockchain adoption cost. The platform is capable of strategically designing the channel structure to encourage (while discouraging) blockchain participation by the manufacturer. Our analysis highlights the complementarity between blockchain participation and the channel structure. Furthermore, the effect of the consumer’s belief in the reselling channel, the commission fee in the agency channel, and the substitutability between channels are investigated in depth. The research provides valuable insights for online retail platforms and policymakers seeking to foster a sustainable and trustworthy e-commerce ecosystem.

The graphene based highly conductive and flexible devices has received momentous attraction and growth in recent years for potential multifunctional uses. The development of flexible and washable textile sensors, actuators, energy storage and energy harvesting systems. Textile fabrics coated with graphene and conductive polymers have been used for wearable self-powered e-textiles, such as tribo-electric, piezoelectric, and Thermoelectric. Herein this research, 100% woven cotton fabric is Fictionalized with graphene oxide (GO) using industrial-scale cold pad batch dyeing technique for the development of low-grade body heat into self-powered wearable e-textiles. The conductive polymer PEDOT: PSS was coated using layer by layer approach. The study demonstrates that the resultant textile electrodes showed reduced electrical sheet resistance from 2.5 MΩ to 15KΩ, with a reduced graphene oxide and further reduced to (2.5 -12.5 Ω) for conductive polymer. The sheet resistance was decreased with the number of dyeing cycles (10-15) and increased with 20 washing cycles vice versa. The study demonstrates that the sensor response and performance were improved with increasing the content percent of rGO and PEDOT: PSS. The tensile strength of as coated fabric electrodes was improved from (25.0-85.5 mPa) and fabric thickness was increased to (26-38µm) without compromising or influencing the air permeability. The resultant textile electrodes may potentially be used in smart textiles for self-powered flexible wearable generators, sensors, and energy storage. The study demonstrates that the cold pad batch dyeing method is a suitable and effective method for the fabrication of graphene-based textiles.

Interoperable multilayer networks are pivotal and transformative in public digital health. They not only enhance the delivery of healthcare services but also contribute significantly to improving public health outcomes. Through better accessibility, efficiency, and data-driven decision-making, these networks are revolutionizing how we approach public health. The seamless data exchange and integration they facilitate across different healthcare systems and providers can lead to substantial cost savings for public healthcare systems. These networks pave the way for a more efficient and effective healthcare system by reducing redundancies, optimizing resource allocation, and minimizing unnecessary procedures. This study combines the pressing issues of public digital health with the innovative interpretation of multilayer network theory, proposing practical solutions that inspire academics and practitioners alike.Public digital health is not just about improving care access and patient engagement. It is also about ensuring the financial sustainability of our healthcare systems. Innovative multilayer network analysis is critical in this game, improving interoperability and reducing spatial and temporal constraints. These networks streamline processes and improve efficiency by easing complex interactions within healthcare systems. This process, in turn, allows healthcare providers to deliver high-quality care at a lower cost, transforming, whenever possible, in-patients and out-patients into home-patients. Networks are a cornerstone and a beacon of hope for transforming public digital health. They are increasing the Value for Money and enhancing a patient-centric approach, making us optimistic about the future of healthcare.This study shows that revolutionizing digital healthcare methodologies has a profound impact on crucial elements like resilience, interoperability, and patient well-being within public health. The enhancement of interoperability facilitates the smooth flow of data exchange across various platforms and healthcare providers, fostering improved collaboration and decision-making processes and elevating the safety of patients.

Background: A Morel–Lavallée lesion (MLL) is a traumatic, internal closed degloving injury that results from shearing of subcutaneous tissue away from underlying fascia, usually associated with high-velocity trauma. Case presentation: A 52-year-old man was transported to hospital for further follow-up of a superficial femoral artery injury. Examination on admission showed bruising seen around the left thigh. Contrast-enhanced computed tomography of the left thigh revealed hematoma with extravasation from a branch of the left superficial femoral artery, but no apparent aneurysms or femoral fractures. The patient was treated with compression bandages and discharged on hospital day 6. He left hospital able to walk unaided. He subsequently complained of left thigh pain with swelling and visited the hospital several times. He was treated at another outpatient clinic and was diagnosed with MLL. Single-use disposable portable negative pressure wound therapy (NPWT) was applied for about 2 months, achieving a stable wound site. Conclusion: We encountered a case of MLL successfully treated with single-use portable NPWT. This report presents the case of a patient with isolated MLL without fracture in the left thigh, in which the diagnosis was missed on initial admission. Finally, the patient received minor interventions including drainage along with tissue debridement and portable NPWT. We reviewed the relevant literature and summarize the pathogenesis, clinical manifestations, and treatment strategies for MLL. Emergency physicians require an increased understanding of MLL to avoid misdiagnosis and missed diagnosis.

Current VAT rules for cross-border e-commerce companies in the EU are not sustainable, because they are extremely complex and often opaque, due to the lack of tax harmonization. The aim of the research is to explore, using a qualitative method, what kind of harmonization would make the current legislation more uniform, simpler, more transparent, and easier to understand, without conflicting with the rules of any Member State. To this end, the aspects of the new platform regulation introduced on 1 July 2021 and its potential for expansion are assessed through information from possible sales models. The research suggests that the rules on platforms do not cover all possible sales models, which in our view imposes an unnecessary extra administrative burden on some businesses and makes their tax activities less transparent. In the light of the results of the research, we propose that the current EU platform regulation should be extended to cover B2B, B2C transactions and services. As a result of this suggested harmonization, a simpler, more transparent, uniform and sustainable tax system would contribute to the whitening of the economy, generating additional tax revenue for Member States.

Background and Objectives: In recent years Electronic scooters (E-Scooters) have gained popularity, whether for private use or as a publicly available transportation method. With introduction of these vehicles, reports of E-Scooter related accidents have surged, sparking a public debate and concern. Aim of this study was to analyse epidemiological data, characteristics and severity of traumatic brain injury (TBI) related to E-Scooter accidents. Materials and Methods: This retrospective case series evaluated 28 patients who were admitted to three largest neurosurgery clinics in Riga, Latvia between time period from April to October in two separate years – 2022 and 2023 after an E-Scooter related accident. Data were collected on patient demographics, time of the accident, alcohol consumption, helmet use, type of TBI, other related injuries, treatment and assessment at discharge. Results: A total of 28 patients were admitted with TBI related to E-Scooter use, with median age 30 years (Q1-Q3, 20.25-37.25), four individuals under age of 18, majority (64%) were male. In 23 cases the injury mechanism was fall, in 5 cases collision. None were wearing a helmet at time of injury. Alcohol intoxication was evident in over half of the patients (51.5%), with severe intoxication (&gt;1.2ppm) in 75% cases among them. Neurological symptoms upon admission were noted in 50% of cases. All patients had intracranial trauma - 50% brain contusions, 43% traumatic subdural hematoma, almost 30% - epidural hematoma. Craniofacial fractures were evident in 71% of cases, fractures in other parts of body in 3 patients. 6 patients required emergency neurosurgical intervention. Neurological complications were noted in 2 patients, 1 patient died. Conclusions: E-Scooter related accidents result in a significant number of brain and other associated injuries, with notable frequency linked to alcohol influence and lack of helmet use. Prevention campaigns to raise awareness of potential risks and implementation of more strict regulations should be done.

We show that Universe inflation occurs when Einstein's gravity couples to nonlinear electromagnetic fields with cosmic stochastic magnetic fields background. Nonlinear electrodynamics with two parameters is used. The strength of magnetic fields to have the Universe inflation is obtained. It is shown that singularities of the energy density and pressure are absent for any scale factors. At large scale factors one arrives at equation of state for ultra-relativistic case. It is demonstrated that the curvature invariants do not have singularities. By computing the deceleration parameter we show that graceful exit takes place with reasonable e-folding number. The duration of Universe inflation as a function of model parameters is obtained. The classical stability and causality are analyzed by calculating the speed of the sound.

In recent years, e-commerce platforms have replaced conventional marketplaces. People are rapidly adopting internet shopping due to the convenience of making purchases from the comfort of their homes. Online review sites allow customers to share their thoughts on products and services. Customers and businesses are increasingly relying on online reviews to assess and improve the quality of products. Existing literature uses Natural language processing (NLP) to analyze customer reviews for different applications. Due to the growing importance of NLP for online customer reviews, this study attempts to provide a taxonomy of NLP applications based on existing literature. This study also examined emerging methods, data sources, and research challenges by reviewing 154 publications from 2013 to 2023 that explore state-of-the-art approaches for diverse applications. Based on existing research, the taxonomy of applications divides literature into five categories: sentiment analysis, review analysis, customer feedback and satisfaction, user profiling, and marketing and reputation management. It is interesting to note that the majority of existing research relies on Amazon user reviews. Additionally, recent research has encouraged the use of advanced techniques like Bidirectional Encoder Representations from Transformers (BERT), Long Short-Term Memory (LSTM), and ensemble classifiers. The rising number of articles published each year indicates increasing interest of researchers and continued growth. This survey additionally addresses open issues, providing future directions in online customer review analysis.

Energy management systems (EMS) play a central role in improving the performance of microgrids by ensuring their efficient operation while minimizing operational costs and environmental impacts. This paper presents a comprehensive study of a MILP-based EMS developed and implemented in MATLAB using Yalmip software for the energy management of a new positive energy district in the city of Savona, Italy, as part of the Interreg Alpine Space Project ALPGRIDS. The main objective of this research is to optimize the functioning of the microgrid, focusing on cost efficiency and environmental sustainability. In pursuit of this objective, the EMS undergoes comprehensive testing and analysis, replicating actual conditions and addressing the diverse demands of end-users across typical days throughout the year considering real electricity selling and purchase price. The EMS also accounts for the reactive power capabilities of the various technologies integrated into the microgrid. The levelized cost of electricity (LCOE) serves as a metric for assessing curtailment costs, while penalties related to reactive power absorption from the distribution network are appraised in alignment with prevailing regulatory guidelines. The case study provides valuable insights into the practical implementation of EMS technology in microgrids and demonstrates its potential for sustainable energy management in complex urban energy districts. The insights and strategies developed through this research contribute to the overall goals of improving energy efficiency and reducing the environmental footprint of future energy districts.

In an era driven by technology and connectivity, where the sphere of learning goes beyond conventional classrooms, e-Service-Learning (e-SL) merges the possibilities of technology with the principles of experiential education in a powerful blend [1]. Service-learning (SL) is an educational proposal that has been cited by UNESCO [2] as an innovative educational tool through which to address the complex challenges of our society. The Sustainable Development Goals [3] provide a framework around which to structure the SL projects and thus develop the skills needed to act on the full range of goals. Embedding digital means open a debate on the intricate relationship between technology, education, and societal impact [4]. By analyzing two focus groups involving faculty, students and community partners, this contribution aims to explore the potential of combining SL and digital empowerment (DE). The focus group participants discussed the opportunities for innovation, the expected impact on them and the society at large, their needs and the pre-conditions needed to make SL and DE successful, and limitations. The results are presented according to the six principles of sustainability education in the university environment, highlighting the transformative potential of combining these principles within SL and DE.

The rapid advancement of technology has led to increased electronic consumption and a corresponding rise in e-waste generation. To address this issue, this study develops a low-carbon e-commerce closed-loop supply chain (LCE-CLSC) system with remanufacturer, platform, and the government as key stakeholders. An evolutionary game approach is employed to investigate the system's dynamics, analyzing the impact of stakeholder strategies on system equilibrium. Numerical simulations reveal important findings: Firstly, government initiatives promoting recycling, carbon taxes on traditional products, can incentivize remanufacturers to produce low-carbon items and encourage platform investment in recycling services. Secondly, higher sales revenues motivate remanufacturers to produce low-carbon products. Thirdly, consumer sensitivity to recycling services strengthens waste recovery when platforms increase investments in these services, leading to remanufacturers choosing low-carbon production. Lastly, government subsidies may become ineffective if the cost of remanufacturers' carbon reduction and platforms' recycling services exceeds their affordability. These findings offer insights for the sustainable development of obsolete electronic product recycling systems.