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Preprint ARTICLE | doi:10.20944/preprints202407.0386.v1

Physicochemical Characterization and Antimicrobial Properties of Lanthanide Nitrates in Dilute Aqueous Solutions

Galina M Kuz’micheva, Alexander Trigub, Alexander V. Rogachev, Andrey Dorokhov, Elena N Domoroshchina

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: ; Ln nitrate solutions; X-ray diffraction; X-ray absorption spectroscopy; IR spectroscopy; antimicrobial activity ;

Online: 4 July 2024 (08:58:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1039.v1

Aging Mechanism of Mn-based Prussian Blue Cathode Material by Synchrotron 2D X-ray Fluorescence

Mariam Maisuradze, Min Li, Ilaria Carlomagno, Mattia Gaboardi, Giuliana Aquilanti, Jasper Rikkert Plaisier, Marco Giorgetti

Subject: Chemistry And Materials Science, Electrochemistry Keywords: zinc-ion batteries; aqueous batteries; double-metal hexacyanoferrate.; Prussian Blue; x-ray fluorescence; x-ray techniques; XAS; XRD

Online: 18 March 2024 (12:21:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1007.v1

Flux Growth and Characterization of Bulk InVO4 Crystals

Olesia Voloshyna, Mikhail V. Gorbunov, Daria Mikhailova, Andrey Maljuk, Silvia Seiro, Bernd Büchner

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: flux-growth; indium vanadate; XANES (X-ray absorption near edge spectroscopy); EXAFS (extended X-ray absorption fine structure)

Online: 14 September 2023 (11:43:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0476.v1

Phase Evolution and Textural Changes during the Direct Conversion and Storage of CO₂ to Produce Calcium Carbonate from Calcium Hydroxide

Meishen Liu, Greeshma Gadikota

Subject: Engineering, Chemical Engineering Keywords: ultra-small angle X-ray scattering (USAXS); small angle X-ray scattering (SAXS); wide angle X-ray scattering (WAXS); calcium hydroxide; calcium carbonate; carbon capture; utilization; and storage; carbon mineralization

Online: 22 October 2018 (06:24:59 CEST)

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Preprint REVIEW | doi:10.20944/preprints202211.0204.v1

Progress and Perspectives of Spectroscopic Studies at Carbon K-edge Using Novel Soft X-ray Pulsed Sources

Zeinab Ebrahimpour, Marcello Coreno, Luca Giannessi, Massimo Ferrario, Augusto Marcelli, Federico Nguyen, Seyed Javad Rezvani, Francesco Stellato, Fabio Villa

Subject: Physical Sciences, Condensed Matter Physics Keywords: Soft X-ray FEL; HHG pulses; time-resolved X-ray spectroscopy; Carbon K-edge; Conical inter-sections; EuPRAXIA@SPARC_LAB

Online: 10 November 2022 (11:47:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.0959.v1

High Prevalence of Myositis-Specific and Associated Antibodies in Patients with Pulmonary Hypertension

R. Tobal, J. Potjewijd, D. P. C. van Doorn, V. van Empel, J. Damoiseaux, P. van Paassen

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Pulmonary Hypertension; Myositis specific antibodies; Myositis associated antibodies; Immunology; auto-antibodies

Online: 14 May 2024 (13:10:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.0263.v1

Cancer‐Associated Fibroblast Heterogeneity in Oral Cancer

Julia Arebro, Che-Min Lee, Kevin L Bennewith, Cathie Garnis

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Cancer‐associated fibroblast, CAF subtype, oral squamous cell carcinoma, tumor microenvironment

Online: 5 December 2023 (11:11:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1202.v1

The Risk of Death among Patients with Healthcare-Associated Infections and Cardiovascular Diseases Admitted in Intensive Care Unit in Romania

Mihaela Alexandra Budianu, Liviu Moraru, Bogdan Mihai Budianu, Judit Kovacs, Septimiu Voidăzan

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: healthcare-associated infections; Intensive Care Unit; cardiovascular diseases, multidrug resistant bacteria

Online: 18 October 2023 (18:26:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1121.v1

Knowledge and Visual Differentiation Ability of the Pressure Injury Classification System and Incontinence-Associated Dermatitis among Hospital Nurses: A Descriptive Study

Seungmi Park, Eun Jung Kim, Son Ja Lee, Eun Jeong Kim, Ji Yeon Lee, Jung Eun Hong

Subject: Public Health And Healthcare, Nursing Keywords: clinical nurses; visual differentiation; diagnostic ability; pressure injury; incontinence-associated dermatitis

Online: 18 October 2023 (10:00:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1794.v1

DNA Promoter Methylation of the ATM, APC, CDO1, RB1, TP53, WIF1 Genes in Patients with Head and Neck Squamous Cell Carcinoma

Segey Kurevlev, Anna Aghjanayan, Leyla Tskhovrebova, Konstantin Gordon, Andrey Polyakov, Mikhail Ratushnyy, Timur Fatkhudinov

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: DNA methylation; cancer associated genes; head and neck squamous cell carcinoma

Online: 25 August 2023 (08:33:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0307.v1

The Consistency of the Distribution Function Conditional Estimate and Application on the Consistency and Asymptotic Normality of the Conditional Hazard Function Estimate for High Dimensional Quasi-Associated Data

Hamza Daoudi, Zouaoui Chikr Elmezouar, Fatimah Alshahrani

Subject: Computer Science And Mathematics, Mathematics Keywords: conditional distribution function; asymptotic normality, conditionalhazard function; quasi-associated; functional data

Online: 3 August 2023 (10:53:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0751.v1

Identification of EGF Receptor and Thrombospondin-1 As En-Dogenous Targets of ER-Associated Degradation Enhancer EDEM1 in HeLa Cells

Kohta Miura, Riko Katsuki, Shusei Yoshida, Ren Ohta, Taku Tamura

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Endoplasmic reticulum-associated degradation (ERAD); EDEM1; ER chaperone; EGF receptor; TSP1

Online: 12 June 2023 (03:58:21 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0160.v2

NIH SenNet Consortium: Mapping Senescent Cells in the Human Body to Understand Health and Disease

Patty J Lee, Philip Blood, Katy Börner, Judith Campisi, Feng Chen, Heike Daldrup-Link, Phil De Jager, Li Ding, Francesca E. Duncan, Oliver Eickelberg, Rong Fan, Toren Finkel, Vesna Garovic, Nils Gehlenborg, Carolyn Glass, Ziv Bar-Joseph, Pragati Katiyar, So-Jin Kim, Melanie Königshoff, George Kuchel, Haesung Lee, Jun H. Lee, Jian Ma, Qin Ma, Simon Melov, Kay Metis, Ana L. Mora, Nicolas Musi, Nicola Neretti, João F. Passos, Irfan Rahman, Juan Carlos Rivera-Mulia, Paul Robson, Mauricio Rojas, Ananda L. Roy, Birgit Schilling, Pixu Shi, Jonathan Silverstein, Vidyani Suryadevera, Jichun Xie, Jinhua Wang, An-Kwok Ian Wong, Laura Niedernhofer

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Cellular Senescence Network; Normal Aging; Senescence; Senescence-associated secretory phenotype; SenNet

Online: 15 September 2022 (12:52:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0232.v1

The microRNAs in the Antennae of Apolygus lucorum (Hemiptera: Miridae): Expression Properties and Targets Prediction

Adel Khashaveh, Xingkui An, Shuang Shan, Xiaoqian Pang, Yan Li, Xiaowei Fu, Yongjun Zhang

Subject: Biology And Life Sciences, Insect Science Keywords: Small RNA sequencing; miRNAs; Target prediction; Chemosensory-associated genes; Apolygus lucorum

Online: 18 February 2022 (10:01:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0573.v1

Epidemiological and Microbiological Aspects of Health Care-associated Infections in Ukraine During the 2009–2019 Period

Yulian Konechnyi, Marta Panas, Iryna Tymchuk, Roksolana Konechna, Olena Borysiuk, Iryna Hubytska, Lesya Zhurakhivska, Olena Korniychuk

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: healthcare-associated infections; HCAIs; hospital acquired infections; nosocomial infections; statistical analysis

Online: 24 September 2020 (08:19:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201607.0003.v6

Farey Sequences and the Riemann Hypothesis

Darrell Cox

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Riemann hypothesis, Farey sequence, Gauss sum associated with a Dirichlet character

Online: 10 August 2016 (11:35:25 CEST)

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Preprint SHORT NOTE | doi:10.20944/preprints202409.0592.v1

(R)-2-Amino-1-Hydroxyethylphosphonic Acid

Majid Motevalli, Isaac Abrahams, Peter Blakskjær, Caroline E. Wyatt, Peter B. Wyatt

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: X-ray structure; amino phosphonic acid; hydrogen bonding

Online: 9 September 2024 (08:28:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.1150.v1

An Examination of the Very First Polarimetric X-ray Observations of Radio-quiet Active Galactic Nuclei

Frédéric Marin, Vittoria Elvezia Gianolli, Adam Ingram, Dawoon E Kim, Andrea Marinucci, Daniele Tagliacozzo, Francesco Ursini

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: X-ray polarization; high-energy processes; black holes

Online: 17 June 2024 (14:45:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1768.v1

Implementation of Portable Digital Chest X-Ray Machine for Tuberculosis Contact Tracing in Oyo and Osun States, Nigeria: A Formative Assessment

Aderonke Agbaje, Patrick Dakum, Olugbenga Daniel, Anyaike Chukwuma, Obioma Chijoke-Akaniro, Evaezi Okpokoro, Samuel Akingbesote, Christian Anyomi, Adekola Adekunle, Abiola Alege, Moroof Gbadamosi, Olutunde Babalola, Mensah Charles, Rupert Eneogu, Austin Ihesie, Debby Nongo, Ademola Adelekan

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Keywords Tuberculosis; Contact investigations; Portable X-ray machine

Online: 27 May 2024 (14:28:08 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202404.1370.v1

F10 Gene Expression and Ethnic Disparities Present in Papillary Thyroid Carcinoma

Tyrel Porter, Lilia Kucheryavykh

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Papillary Thyroid Carcinoma; Ethnic Disparities; Factor X; F10

Online: 22 April 2024 (10:17:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.2321.v2

Galactic Spiral from ROTASE Model with Large Enough ρ Is Equivalent to Archimedean Spiral

Hongjun Pan

Subject: Computer Science And Mathematics, Mathematics Keywords: Galactic spiral; Prime spiral; ROTASE model; X-matter

Online: 4 January 2024 (07:24:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1804.v1

Tuberculosis Case Finding in Kulon Progo District, Yogyakarta, Indonesia: Passive Versus Active Case Finding Using Mobile Chest X-ray

John Silwanus Kaku, Riris Andono Ahmad, Stephanie Main, Dwi Oktofiana, Bintari Dwihardiani, Rina Triasih, Philipp Du Cros, Geoffrey Chan

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: tuberculosis; active-case finding; mobile chest X-ray

Online: 28 November 2023 (10:25:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0085.v1

X-ray Exited Optical Luminescence of Eu in Diamond Crystals Synthesized at High-pressure High-temperature

Vasily Timofeevich Lebedev, Fedor Mikhailovich Shakhov, Alexandr Yakovlevich Vul, Arcady Anatolievich Zakharov, Vladimir Georgievich Zinoviev, Vera Alexeevna Orlova, Eduard Vladimirovich Fomin

Subject: Chemistry And Materials Science, Nanotechnology Keywords: diamond; synthesis; diphthalocyanine; pyrolyzate; lanthanide; X-ray; luminescence

Online: 6 December 2022 (01:35:19 CET)

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Preprint REVIEW | doi:10.20944/preprints202201.0183.v1

Mechanisms of Choice in X-Chromosome Inactivation

Giulia Furlan, Rafael Galupa

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: X-chromosome inactivation; allelic choice; skewing; placentals; marsupials

Online: 12 January 2022 (18:52:02 CET)

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Preprint REVIEW | doi:10.20944/preprints202110.0083.v1

Multilayer Reflective Coatings for BEUV Lithography: A Review

Paul C. Uzhoma, Salman Shabir, Huan Hu, Paul C. Okonkwo, Oleksiy V. Penkov

Subject: Physical Sciences, Condensed Matter Physics Keywords: BEUV lithography; Multilayer mirrors; X-ray optics; reflectivity

Online: 5 October 2021 (12:44:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0045.v1

A Fully Coaxial Tunable Broadband Power Equalizer for an X-band MPM

Patrizia Livreri, Fabio Lo Gerfo

Subject: Engineering, Electrical And Electronic Engineering Keywords: Broadband power equalizer; coaxial; MPM; TWT; X-band

Online: 4 February 2020 (10:45:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints201908.0095.v1

Crystal Structure of African Swine Fever Virus A179L with the Autophagy Regulator Beclin

Suresh Banjara, Gareth Shimmon, Linda Dixon, Christopher Netherton, Mark Hinds, Marc Kvansakul

Subject: Biology And Life Sciences, Virology Keywords: Autophagy, Bcl-2, Beclin, ASFV, X-ray crystallography

Online: 7 August 2019 (10:10:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0027.v1

Chemostratigraphy of the Upper Jurassic (Oxfordian) Smackover Formation for Little Cedar Creek and Brooklyn Fields, Alabama

Rian Engle, Lance D. Yarbrough, Greg Easson

Subject: Environmental And Earth Sciences, Geochemistry And Petrology Keywords: x-ray fluorescence, paleo-depositional environments; porosity correlation

Online: 3 January 2019 (13:54:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints201809.0359.v1

In-Situ Coherent X-Ray Diffraction during Three-Point Bending of a Au Nanowire: Visualization and Quantification

Anton Davydok, Thomas W. Cornelius, Zhe Ren, Cedric Leclere, Gilbert Chahine, Tobias Schülli, Florian Lauraux, Gunter Richter, Olivier Thomas

Subject: Chemistry And Materials Science, Nanotechnology Keywords: synchrotron X-ray diffraction; nano-structures; nano mechanics

Online: 18 September 2018 (16:50:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0332.v1

Microdrop Deposition Technique: Preparation and Characterization of Diluted Suspended Particulate Samples

Salvatore Macis, Giannantonio Cibin, Valter Maggi, Giovanni Baccolo, Dariush Hampai, Barbara Delmonte, Alessandro D'Elia, Augusto Marcelli

Subject: Chemistry And Materials Science, Other Keywords: ultra-dilution; droplets; water; evaporation; X-ray fluorescence

Online: 24 May 2018 (05:43:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0171.v1

Fracture Reconstruction and Analysis of Low Permeability Carbonates using x-ray Tomography for Comparison with Outcrop Data

Stephanie G. Zihms, Helen Lewis, Tiago Siqueira de Miranda, Stephen A. Hall, James M. Somerville

Subject: Environmental And Earth Sciences, Geography Keywords: geomechanics; fractures; multi-scale; x-ray tomography; carbonates

Online: 10 May 2018 (16:24:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201711.0003.v1

Wetland Mapping Using SAR Data from Sentinel-1A and TanDEM-X Missions: Comparative Study in the Biebrza Floodplain (Poland)

Magdalena Mleczko, Marek Mróz

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: Sentinel-1A; TanDEM-X science phase; wetlands mapping

Online: 1 November 2017 (04:37:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints201612.0110.v1

The Synthesis and New Crystal Structures of Three Arylpiperazine Compounds

Jinhui Zhou, Maocai Yan, Maojian Shi, Jun Xu, Guoqiang Shangguan

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: arylpiperazine compound; X-ray crystal structure; characterization; triclinic

Online: 21 December 2016 (11:01:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0875.v1

Structural Evolution of the Pharmaceutical Peptide Octreotide upon Controlled Relative Humidity and Temperature Variation

Maria Athanasiadou, Christina Papaefthymiou, Angelos Kontarinis, Maria Spiliopoulou, Dimitrios Koutoulas, Marios Konstantopoulos, Stamatina Kafetzi, Kleomenis Barlos, Kostas K. Barlos, Natalia Dadivanyan, Detlef Beckers, Thomas Degen, Andrew N. Fitch, Irene Margiolaki

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: humidity variation; temperature variation; X-ray crystallography; peptides; polymorphism; octreotide; drug stability; in situ X-ray powder diffraction

Online: 15 April 2024 (11:34:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0189.v1

An Effective Method for InSAR Mapping of Tropical Forest Degradation in Hilly Areas

Harry Carstairs, Edward T. A. Mitchard, Iain McNicol, Chiara Aquino, Andrew Burt, Medard Obiang Ebanega, Anaick Modinga Dikongo, Jose-Luis Bueso-Bello, Mathias Disney

Subject: Environmental And Earth Sciences, Environmental Science Keywords: InSAR; TanDEM-X; forest degradation; biomass change; Synthetic Aperture Radar; SAR; Carbon cycle; Satellite data; Earth Observation; DLR; X-band

Online: 9 November 2021 (15:43:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints201910.0168.v1

An Affordable Image Detector and a Low-Cost Evaluation System for Computed Tomography Using Neutrons, X-Rays or Visible Light

Burkhard Schillinger

Subject: Physical Sciences, Radiation And Radiography Keywords: neutron imaging; neutron detector; X-ray detector; CCD camera; CMOS camera; collimator; X-rays; image processing; computed tomography; CT reconstruction

Online: 15 October 2019 (11:15:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1815.v1

An Integrated Approach Based on Clinical Data Together with Metabolites and Biomarkers for the Assessment of the Postoperative Complications after Cardiac Surgery

Peter Meinarovich, Alisa Pautova, Evgenii Zuev, Ekaterina Sorokina, Ekaterina Chernevskaya, Natalia Beloborodova

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: aromatic microbial metabolites; sepsis-associated metabolites; 4-hydroxyphenyllactic acid; prognostic models; SOFA

Online: 23 July 2024 (16:04:39 CEST)

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Background: Early diagnosis of postoperative complications is an urgent task, allowing timely prescribing of appropriate therapy and reducing the cost of patient treatment. Prognostic models based on various data could help in the early diagnosis of postoperative complications after cardiac surgery. Objectives: The purpose of the study was to determine whether an integrated approach based on clinical data along with metabolites and biomarkers had greater predictive value than the models built on less data. Methods: The study included patients (n=62) admitted for planned cardiac surgery (coronary artery bypass grafting with cardiopulmonary bypass), who were retrospectively divided into two groups depending on the presence (n=26) or absence (n=36) of postoperative complications of all types. Clinical and laboratory data on the first day after surgery were analyzed. Additionally, patients' blood samples were collected before and on the first day after surgery to determine biomarkers (interleukin-6, procalcitonin, NT-proBNP, high-sensitivity troponin T) and metabolites (8 aromatic and 2 dicarboxylic acids were detected using gas chromatography-mass spectrometry). Results: Patients before surgery, compared with healthy donors, differed in the concentration of metabolites (p < 0.05), and had concentrations of a number of biomarkers exceeding the corresponding reference values. Multivariate PLS-DA models, predicting the presence or absence of postoperative complications, were built using clinical data (ROC-AUC=0.71), concentrations of metabolites and biomarkers (ROC-AUC=0.60), and the entire data set (ROC-AUC=0.75). For comparison we built univariate models using the EuroScore2 (ROC-AUC=0.59) and SOFA (ROC-AUC=0.76) scales; concentrations of lactate (ROC-AUC=0.71), the dynamic changes of 4-hydroxyphenyllactic acid (ROC-AUC=0.69), and the sum of three sepsis-associated metabolites (ROC-AUC=0.70). The proposed complex model using entire data set was comparable to the SOFA scale, which confirms the expediency of searching for new predictive models based on a variety of factors.

Preprint ARTICLE | doi:10.20944/preprints202312.2085.v1

Evaluation of the Antibacterial Activity of New Dermaseptin Derivatives against Acinetobacter baumannii

Houda HADDAD, Radhia MEJRI, Alyne Rodriguez De ARAUJO, Amira Zaïri

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Dermaseptin B2; Dermaseptin S4; analogs; Acinetobacter baumannii; Healthcare-Associated Infections; Antibacterial activity

Online: 27 December 2023 (10:24:49 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.1080.v1

Brief Electrical Stimulation Ameliorates Poor Recovery after Surgical Repair of Injured Peripheral Nerves

Tessa Gordon

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: peripheral nerve regeneration; delayed surgical nerve repair; regeneration associated genes; electrical stimulation

Online: 17 October 2023 (11:02:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1231.v1

Molecular Mechanisms of Pentagalloyl Glucose-Mediated Stabilization of Abdominal Aortic Aneurysms

Dan Simionescu, Nishanth Tharayil, Elizabeth Leonard, Wenda Carlyle, Alex Schwarz, Kelvin Ning, Christopher Carsten, Juan Carlos Carrillo Garcia, Alexander Carter, Collin Owens, Agneta Simionescu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: aneurysms; polyphenols; diffusion; stabilization; docking simulations; elastin; collagen; elastin-associated microfibrillar proteins

Online: 16 June 2023 (11:04:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1213.v1

Unravelling the Immune Microenvironment in Classic Hodgkin Lymphoma: Prognostic and Therapeutic Implications

Vasileios Georgoulis, Alexandra Papoudou-Bai, Alexandros Makis, Panagiotis Kanavaros, Eleftheria Hatzimichael

Subject: Medicine And Pharmacology, Hematology Keywords: Hodgkin lymphoma; tumor microenvironment; tumor associated macrophages; CD169+ macrophages; immune evasion; immunosuppression

Online: 17 May 2023 (09:37:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0470.v1

Kaposi’s Sarcoma-associated Herpesvirus ORF21 Enhances the Phosphorylation of MEK and the Infectivity of Progeny Virus

Tatsuo Yamaguchi, Tadashi Watanabe, Yuki Iwaisako, Masahiro Fujimuro

Subject: Biology And Life Sciences, Virology Keywords: Kaposi’s sarcoma-associated herpesvirus; MEK; thymidine kinases; lytic replication; infectivity; ORF21; herpesvirus

Online: 25 November 2022 (06:13:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0099.v1

Extracellular Secretomes of Leptospira Interrogans Serovar Icterohemorrhagiae Respond to the In Vivo Mimic of Physiological Osmolarity and Temperature Transition

Tipparat Thiangtrongjit, Onrapak Reamtong, Weerapong Phumratanapraphin, Direk Limmathurotsakul, Surapong Chatpun, Mingkwan Odton, Muthita Vanaporn, Pornpan Pumirat, Usa Boonyuen, Sumate Ampawong, Ngamphol Soonthornworasiri, Poom Adisakwattana, Urai Chaisri, Santi Maneewatchararangsri

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Leptospira spp., secretome; virulent-associated secreted proteins; in-vivo mimic mammalian condition

Online: 9 October 2022 (02:07:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0423.v1

Is “Cellular Senescence” a Misnomer?

David Gems, Carina Kern

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Aging; cellular senescence; fibroblast; osteoarthritis; remodeling-associated secretory phenotype (RASP); remodeling activation

Online: 27 July 2022 (13:38:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202205.0340.v1

Unlocking the Molecular and Biochemical Machinery of Insect Herbivore Resistance: the Key is a Perception of Herbivore-Associated Elicitors

Saiful Malook, Saiqa Maqbool, Muhammad Hafeez, Samantha Chandranath Karunarathna, Nakarin Suwannarach

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: herbivore-associated elicitors; plant defense; secondary metabolites; signaling metabolites; pattern recognition receptors

Online: 25 May 2022 (03:53:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints202203.0148.v1

Peptide: N-Glycanase 1 and Its Relationship with Congenital Disorder of Deglycosylation

Xiangguang Miao, Jin Wu, Hongping Chen, Guanting Lu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: N-glycosylation; NGLY1; ER associated degradation process; congenital disorder of deglycosylation; NFE2L1

Online: 10 March 2022 (12:51:22 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202104.0774.v1

Wuhan's Experience in Fighting COVID-19: Achieving Zero Case of COVID-19 Infection among Healthcare Workers

Anhua Wu, liuyi li, Caixia Tan, Xiujun Meng, Xudong Ma, Chunhui Li

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: COVID-19; infection control; healthcare-associated infections; healthcare workers; SARS-CoV-2

Online: 29 April 2021 (11:35:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0479.v1

Suboptimal Health Status of High School Students in Guangzhou, Shanxi, and Tibet, China: A Cross-Sectional Study

Gehendra Mahara, Jiazhi Liang, Zhirong Zhang, Qi Ge, Jinxin Zhang

Subject: Medicine And Pharmacology, Other Keywords: suboptimal health status; associated factors; high school students; Shanxi; Guangzhou; Tibet; China

Online: 20 September 2020 (14:50:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0501.v1

Novel Circoviruses Detected in Feces of Sonoran Felids

Natalie Payne, Simona Kraberger, Rafaela S Fontenele, Kara Schmidlin, Melissa H Bergeman, Ivonne Cassaigne, Melanie Culver, Arvind Varsani, Koenraad Van Doorslaer

Subject: Biology And Life Sciences, Virology Keywords: circoviridae; circoviruses; bobcat; lynx rufus; Sonoran desert; Sonoran felid associated (Sonfela) circoviruses

Online: 24 August 2020 (03:09:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0445.v1

Oral Tumour Cell Migration and the Effect of the Local Soluble Factors from the Microenvironment on Signalling Pathways. Is It All about the Akt?

Hanan Ahmed, Arpa Ghoshal, Sarah Jones, Ian Ellis, Mohammad Islam

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: oral cancer; cancer-associated fibroblasts; metastasis; cell migration; cell invasion; Akt; EGFR

Online: 27 May 2020 (08:25:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201610.0060.v1

Impact of Soft Tissue Pathophysiology in the Development and Maintenance of Bisphosphonate Related Osteonecrosis of the Jaw (BRONJ)

Thomas Ziebart, Sebastian Blatt, Junho Jung, Andreas Pabst, Christian Walter, Frank Halling, Paul Heymann, Andreas Neff, Leonardo Righesso

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: gingiva; bisphosphonate; soft tissue; fibroblasts; keratinocytes; bisphosphonate associated osteonecrosis of the jaws

Online: 15 October 2016 (08:03:48 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202408.1591.v1

Comparison of Chest Ct Findings and Pulmonary Function Tests in Non-symptomatic Children with Rheumatic Diseases

Spyridon Prountzos, Kyveli Chiotopoulou, Katerina Kourtesi, Evdoxia Sapountzi, Dafni Moriki, Elpiniki Kartsiouni, Efthymia Alexopoulou, Konstantinos Douros, Lampros Fotis

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Lung; Pediatrics; Rheumatic Diseases; Spirometry; Tomography, X-ray Computed

Online: 21 August 2024 (16:00:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0555.v1

The Potential of Twendee X®︎ as a Safe Antioxidant Treatment for Systemic Sclerosis

Fukka You, Carole Nicco, Yoshiaki Harakawa, Toshikazu Yoshikawa, Haruhiko Inufusa

Subject: Biology And Life Sciences, Life Sciences Keywords: Oxidative stress; Twendee X®︎; Antioxidant; Systemic sclerosis; autoimmunity

Online: 9 February 2024 (07:37:59 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202401.1545.v1

Parenchymal Cavitations in Pulmonary Tuberculosis: Comparison between Lung Ultrasound, Chest X-ray and Computed Tomography

Diletta Cozzi, Maurizio Bartolucci, Federico Giannelli, Edoardo Cavigli, Irene Campolmi, Francesca Rinaldi, Vittorio Miele

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Lung Ultrasound; Chest x-ray; Tuberculosis; Computed Tomography; Infection

Online: 22 January 2024 (10:11:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.2156.v1

Analysis of Underlapped Symmetrically Ported Valve Controlled Asymmetric Cylinder Drive

Huankun Wang, Man Xu, Zijian Cao

Subject: Engineering, Mechanical Engineering Keywords: Moog; asymmetric cylinder; analytical solution; component linking; X-factor

Online: 29 December 2023 (01:21:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1990.v1

Enhancing Finger Fracture Diagnosis: A Deep Learning Approach Using ResNet and VGG

Shinawar Naeem, Asma Naseer, Shafiq ur Rehman, Volker Gruhn, Sheeraz Akram

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Classification; Transfer Learning; Deep learning; Finger Fracture; X-Rays

Online: 30 November 2023 (14:10:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0355.v1

X-linked Gusher Disease DFNX2 in Children, a Rare Inner Ear Dysplasia with Conductive Hearing Loss

Soumit Dasgupta, James Hong, Rhyanna Morris, Javed Iqbal, Amy Lennox, Jeyasakthy Saniasiaya

Subject: Medicine And Pharmacology, Otolaryngology Keywords: Third window; X-linked gusher; hearing loss; audiovestibular; POU3F4

Online: 6 July 2023 (09:16:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0783.v1

Asymmetries in Strong Solar Flares

Eugene Bagashov

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Sun: activity; Sun: flares; Sun: X-rays; gamma-rays

Online: 12 June 2023 (07:20:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1025.v1

Pressure-Induced Structural Phase Transition of Co-Doped SnO2 Nanocrystals

Vinod Panchal, Laura Pampillo, Sergio Ferrari, Vitaliy Bilovol, Catalin Popescu, Daniel Errandonea

Subject: Physical Sciences, Condensed Matter Physics Keywords: High Pressure; Phase Transition; Synchrotron Radiation, X-ray Diffraction

Online: 15 May 2023 (10:37:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0474.v1

Influence of Probable Precipitation Futures on Strawberries (Fragaria x ananassa): Results from a Simulated Rainfall Experiment

Rachel E. Schattman, Alicyn Smart, Sean Birkel, Haley Jean, Kallol Barai, Yong-Jiang Zhang

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Climate change; agroecology; Fragaria x ananassa; precipitation; rainfall simulation

Online: 29 December 2021 (23:20:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0574.v1

Use of X-Ray Mutagenesis to Increase Genetic Diversity of Zantedeschia aethiopica for Early Flowering, Improved Tolerance to Bacterial Soft Rot and Higher Yield

Noam Reznik, Bijaya Sharma Subedi, Shoshana Weisman, Gavriel Friesem, Nir Carmi, Iris Yedidia, Michal Sharon-Cohen

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Zantedeschia aethiopica; X-ray mutagenesis; cultivation; Pectobacterium; mutation breeding

Online: 30 November 2021 (14:42:05 CET)

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Preprint REVIEW | doi:10.20944/preprints202108.0463.v1

Negative CO₂ Emissions from Flexible Biofuel Synthesis: Concepts, Potentials, Technologies

Emanuele Moioli, Tilman Schildhauer

Subject: Engineering, Energy And Fuel Technology Keywords: Power-to-X; Biomass; Biogas; renewable energy; energy storage

Online: 24 August 2021 (10:33:03 CEST)

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Working Paper ARTICLE

Single Cell Cryo-soft X-ray Tomography Shows that Each Chlamydia Trachomatis Inclusion is a Unique Community of Bacteria

Patrick Phillips, James M. Parkhurst, Ilias Kounatidis, Chidinma Okolo, Thomas M. Fish, James H. Naismith, Martin A. Walsh, Maria Harkiolaki, Maud Dumoux

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Chlamydia; bacteria community; cryo-soft X-ray tomography; segmentation

Online: 16 July 2021 (08:57:06 CEST)

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Working Paper ARTICLE

Howard Flack and The Flack Parameter

David John Watkin, Richard Ian Cooper

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Howard Flack; Flack Parameter; Structure Analysis; X-ray Crystallography

Online: 26 August 2020 (05:01:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0609.v1

PyAtomDB: Extending the AtomDB Atomic Database to Model New Plasma Processes and Uncertainties

Adam R. Foster, Keri Heuer

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: X-ray Spectroscopy; Atomic Data; Spectral Analysis; Error Analysis

Online: 25 July 2020 (15:29:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0318.v1

Durability and Microstructural Properties of Triple-Binder-Stabilized Marine Deposit Clay

Mohamad Hanafi, Abdullah Ekinci, Ertug Aydin

Subject: Engineering, Civil Engineering Keywords: reuse; soil; X-ray techniques; binder; cement; durability; microstructure

Online: 23 March 2020 (00:23:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0050.v1

Zn(II) Complex for Highly Sensitive and Selective Detection of Acetone at Room Temperature

Mohd. Muddassir, Abdullah Alarifi, Mohammad Usman

Subject: Chemistry And Materials Science, Inorganic And Nuclear Chemistry Keywords: x-ray crystallography; h-bonding; acetone; fluorescence sensing; dft

Online: 4 December 2019 (12:22:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints201904.0299.v1

Green Synthesis, Structural, In Vitro and Vivo Bioactivity Properties of ZnO Nanoparticles for Biomedical Applications

Essam H. Ibrahim, Obaid Albulym, Omer Kaygili, Mona Kilany, Mohd Shkir, Mai S.A. Hussien, Niyazi Bulut, I.S. Yahia

Subject: Chemistry And Materials Science, Biomaterials Keywords: X-ray diffraction; bioactivities; cytotoxicity test; Anti-cancer activities

Online: 26 April 2019 (11:00:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0022.v1

Facile Low Temperature Hydrothermal Synthesis of BaTiO₃ Nanoparticles Studied by In Situ X-ray Diffraction

Ola Gjoennes Grendal, Anders Bank Blichfeld, Susanne Linn Skjarvø, Wouter van Beek, Sverre Magnus Selbach, Tor Grande, Mari-Ann Einarsrud

Subject: Chemistry And Materials Science, Nanotechnology Keywords: BaTiO3; hydrothermal synthesis; in situ; X-ray diffraction; nanoparticles

Online: 2 May 2018 (11:25:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0260.v1

Synthesis, X-ray Crystal Structures, Computational Studies and Catechol Oxidase Activity of New Acylhydrazone Derivatives

Khalid Karrouchi, Smaail Radi, Yousfi El Bekkaye, Nada Kheira Sebbar, Jamal Taoufi Taoufik, Younes Ouzidan, Hazem A. Ghabbour, Yahia Mabkhot, Salim Al-Showiman, Seham Alterary, M’hammed Ansar

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: Acylhydrazone; Pyrazole; X-ray crystallography; DFT/B3LYP; Catecholase activity

Online: 28 January 2018 (12:44:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints201705.0016.v1

CSL Collapse Model Mapped with the Spontaneous Radiation

Kristian Piscicchia, Angelo Bassi, Catalina Curceanu, Raffaele Del Grande, Sandro Donadi, Beatrix Hiesmayr, Andreas Pichler

Subject: Physical Sciences, Quantum Science And Technology Keywords: quantum mechanics; the measurement problem; collapse models; X-rays

Online: 1 May 2017 (11:02:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0296.v1

Microstructure and Unusual Ferromagnetism of Epitaxial SnO₂ Films Heavily Implanted with Co Ions

Rustam I. Khaibullin, Amir I. Gumarov, Iskander R. Vakhitov, Andrey A. Sukhanov, Nikolay M. Lyadov, Airat G. Kiiamov, Dilyara M. Kuzina, Valery V. Bazarov, Almaz L. Zinnatullin

Subject: Physical Sciences, Applied Physics Keywords: cobalt implantation; tin dioxide; microstructure; ferromagnetism; scanning electron microscopy; X-ray diffraction; X-ray photoelectron spectroscopy; vibrating sample magnetometry; ferromagnetic resonance; spintronics

Online: 4 January 2024 (07:05:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0463.v1

Airspace Diameter Map – a Quantitative Measurement of All Pulmonary Airspaces to Characterize Structural Lung Diseases

Sanja Blaskovic, Pinelopi Anagnostopoulou, Elena Borisova, Dominik Schittny, Yves Donati, David Haberthür, Zhe Zhou-Suckow, Marcus A. Mall, Christian M. Schlepütz, Marco Stampanoni, Constance Barazzone-Argiroffo, Johannes C. Schittny

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: lung disease; cystic fibrosis; pulmonary emphysema; image analysis; artificial intelligence; X-ray tomographic microscopy; micro-computed X-ray tomography / micro-CT; stereology.

Online: 7 July 2023 (07:12:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0316.v1

The Stroma and Tumor Microenvironment Are Not the Most Instrumental Players in Tumor Cells Immune Evasion, Growth, and Resistance to Therapy

Hatem Tallima, Rashika El Ridi

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Cancer surgery; Cancer radiotherapy; Cancer immunotherapy; Cancer stroma; Cancer-associated fibroblasts; Carcinogenesis; Cancer resistance to immunotherapy; Exosomes; Hypoxia; Neutrophil extracellular traps; Sphingomyelin; Neutral sphingomyelinase; Tumor microenvironment; Tumor-associated macrophages

Online: 22 June 2022 (10:25:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0433.v1

Innovative Analytical Method for X-Ray Imaging and Space-Resolved Spectroscopy of ECR Plasmas

Eugenia Naselli, Richard Rácz, Sandor Biri, Maria Mazzaglia, Luigi Celona, Santo Gammino, Giuseppe Torrisi, Zoltan Perduk, Alessio Galatà, David Mascali

Subject: Physical Sciences, Fluids And Plasmas Physics Keywords: X-ray Imaging; Plasma Diagnostics; Electron Cyclotron Resonance Ion Sources; High Dynamical Range Analysis; Single-Photon-Counted Images; X-ray Spatially-resolved Spectroscopy

Online: 28 October 2021 (11:39:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0199.v1

Assessment of Adipocyte Transduction Using Different AAV Capsid Variants

Stanislav Boychenko, Alina Abdullina, Victor Laktyushkin, Andrew Brovin, Alexander Egorov

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: adeno-associated virus; viral tropism; adipocytes; adipose tissue; anti-obesity agents; gene therapy

Online: 5 August 2024 (07:11:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0605.v1

Relationship of Metabolic Dysfunction-associated Steatohepatitis-related Hepatocellular Carcinoma with Oral and Intestinal Microbiota: A Cross-Sectional Pilot Study

Takaaki Matsui, Toshiya Morozumi, Yuko Yamamoto, Takashi Kobayashi, Ryo Takuma, Masato Yoneda, Asako Nogami, Takaomi Kessoku, Muneaki Tamura, Yoshiaki Nomura, Toru Takahashi, Yohei Kamata, Shuntaro Sugihara, Kyoko Arai, Masato Minabe, Norio Aoyama, Kenji Mitsudo, Atsushi Nakajima, Motohiro Komaki

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: microbiota; oral bacteria; intestinal bacteria; hepatocellular cancer; metabolic dysfunction-associated steatohepatitis; Porphyromonas gingivalis

Online: 11 June 2024 (08:42:21 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202405.2094.v1

Detection of Mesothelial-to-Mesenchymal Transition-Derived Carcinoma-Associated Fibroblasts in Primary Ovarian Carcinomas

Henar Tomero-Sanz, José Antonio Jiménez-Heffernan, María Concepción Fernández-Chacón, Ignacio Cristóbal-García, Ricardo Sainz de la Cuesta, Lucía González-Cortijo, Manuel López-Cabrera, Pilar Sandoval

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Ovarian cancer; primary tumor; mesothelial cells; carcinoma-associated fibroblasts; mesothelial-to-mesenchymal transition

Online: 31 May 2024 (08:10:16 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202404.1620.v3

Microglial Replacement and COURIER or SPIT for Neuronal Gene Editing

Michael Renteln

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: microglial replacement; adeno-associated viral (AAV) vectors; COURIER; SPIT; base editing; prime editing

Online: 24 May 2024 (11:34:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1186.v1

Factors Contributing to Negative Outcomes Associated with Medications and Drug-Related Problems in Kidney Replacement Therapy. A Hospital-Based Prospective Observational Study

Alfonso Pereira-Céspedes, Alberto Jiménez-Morales, Aurora Polo-Moyano, Magdalena Palomares-Bayo, Fernando Martínez-Martínez, Miguel Ángel Calleja-Hernández

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: kidney replacement therapy; medication review; drug-related problems; negative outcomes associated with medication.

Online: 16 January 2024 (13:57:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0506.v1

Chronic Morphine Treatment and Antiretroviral Therapy Exacerbate HIV-Distal Sensory Peripheral Neuropathy and Induce Distinct Microbial Alterations in the HIV Tg26 Mouse Model.

Irina Chupikova, Danielle Antoine, Richa Jalodia, Praveen Kumar Singh, Sabita Roy

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: HIV-associated pain; neuropathy; opioid use; antiretroviral therapy; gut dysbiosis; Tg26 mouse model

Online: 7 December 2023 (11:24:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0015.v1

A Comprehensive Genetic Study of Microtubule-Associated Genes Clusters for Male Infertility in a Taiwanese Cohort

Chying-Chyuan Chan, Te-Hsin Yen, Hao-Chen Tseng, Brang Mai, Pin-Kuan Ho, Jian-Liang Chou, Gwo-Jang Wu, Yu-Chuan Huang

Subject: Medicine And Pharmacology, Reproductive Medicine Keywords: male infertility; azoospermia; oligozoospermia; next-generation sequencing; single nucleotide polymorphism; microtubule-associated genes

Online: 1 September 2023 (13:38:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.1577.v1

Microglial Activation: Key Players in SepsisAssociated Encephalopathy

Jiyun Hu, Shucai Xie, Haisong Zhang, Xinrun Wang, Binbin Meng, Lina Zhang

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Sepsis-associated encephalopathy; Microglial activation; M1/M2 microglial polarization; cognitive impairment; therapeutic strategies

Online: 22 August 2023 (12:09:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2003.v1

3-Iodothyronamine (T1AM) Reduces Inflammatory Response in Human Microglial HMC3 Cell Line

Beatrice Polini, Caterina Ricardi, Andrea Bertolini, Vittoria Carnicelli, Grazia Rutigliano, Federica Saponaro, Riccardo Zucchi, Grazia Chiellini

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: neurodegeneration; microglia; inflammation; neuroprotection; trace-amine associated receptors type 1 (TAAR1); 3-iodothyronamine

Online: 29 May 2023 (09:35:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0361.v1

Are Hamstring Grafts a Predisposing Factor to Infection in R-Acl Surgery? A Comparative in Vitro Study

Ferran Corcoll, Daniel Pèrez Prieto, Svetlana Karbysheva, Andrej Trampuz, Oscar Fariñas, Joan Carles Monllau

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: arthroscopy; sports medicine; anterior cruciate ligament reconstruction; implant-associated infection; biofilm; septic arthritis.

Online: 5 May 2023 (11:26:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202201.0327.v1

Imaging Cancer-Associated Fibroblasts (CAFs) with FAPi PET

Laura Gilardi, Lighea Simona Airò Farulla, Emre Demirci, Ilaria Clerici, Emanuela Omodeo Salé, Francesco Ceci

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer-associated-fibroblast; fibroblast activation protein; FAPi; Positron emission tomography; FAPi PET; theranostics

Online: 21 January 2022 (13:31:31 CET)

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Working Paper REVIEW

Role of Nucleoid Associated Protein HU in the Intercellular and Extracellular Milieu

Debayan Dey

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: nucleoid-associated proteins (NAPs); moonlighting proteins; drug target; biofilm; specificity determination; phylogenetic analysis

Online: 7 June 2020 (09:07:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints201810.0023.v1

Unfolded Protein Response-Dependent Communication and Contact among Endoplasmic Reticulum, Mitochondria and Plasma Membrane.

Atsushi Saito, Kazunori Imaizumi

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Unfolded protein response; ER morphology; Mitochondria-associated ER membrane; ER-PM contact sites

Online: 2 October 2018 (13:41:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints201809.0521.v1

Unfolded Protein Response-Dependent Communication and Contact among Endoplasmic Reticulum, Mitochondria and Plasma Membrane.

Atsushi Saito, Kazunori Imaizumi

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Unfolded protein response; ER morphology; Mitochondria-associated ER membrane; ER-PM contact sites

Online: 26 September 2018 (15:44:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201707.0059.v1

Sequestration Effect on the Open-Cyclic Switchable Property of Warfarin by Cyclodextrin: Ultrafast Dynamical Study

Naji Al-Dubaili, Na'il Saleh

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: open-cyclic tautomers; molecular switching; decay-associated spectra; warfarin; excited-state lifetime; cyclodextrins

Online: 21 July 2017 (04:56:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints201706.0068.v1

Human MAP tau based targeted cytolytic fusion proteins

Olusiji Akinrinmade, Sandra Jordaan, Dmitrij Hristodorov, Radoslav Mladenov, Neelakshi Mungra, Shivan Chetty, Stefan Barth

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: human cytolytic fusion proteins; immunotherapy; microtubule associated protein tau (MAP); cancer; inflammatory diseases

Online: 15 June 2017 (12:02:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0227.v1

Antimicrobial Peptides for Combating Eukaryotic Pathogens: Anti-Histomonal, and Anti-Leishmanial Potential of Antimicrobial Peptides Released by Entomopathogenic Nematode Symbiont Bacteria

András Fodor, Claudia Hess, Petra Ganas, Zsófia Boros, János Kiss, László Makrai, Károly Dublecz, László Pál, László Fodor, Anna Sebestyén, Michael G. Klein, Eustachio Tarasco, Manjusha M. Kulkarni, Bradford S. McGwire, Tibor Vellai, Michael Hess

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: non-ribosomal antimicrobial peptides (NR-AMP); entomopathogenic nematode-symbiont bacteria (EPB); Xenorhabdus; (X. budapestensis; X. szentirmaii; X. innexii); Photorhabdus (P. luminescens TT01); CFCM; (cellfree conditioned culture media); intracellular mammalian parasite; Leishmania; extracellular avian pathogens; Histomonas; probiotic potential

Online: 3 August 2023 (09:39:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1398.v1

Practical but Inaccurate? A-mode Ultrasound and Bioelectrical Impedance Underestimate Body Fat Percentage Compared to Dual-Energy X-ray Absorptiometry in College Men

Markus Filardi Moura Olinto, Victor César Dias Lins, Gabriel Carvalho Rocha, Marco Aurélio Araújo Dourado, Maurilio Tiradentes Dutra

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: body fat; bioelectrical impedance; ultrasound; dual energy X-ray absortiometry

Online: 20 June 2024 (11:10:28 CEST)

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Preprint SHORT NOTE | doi:10.20944/preprints202405.1782.v1

(S)-1-Methyl-2-Oxoimidazolidine-4-Carboxylic Acid

Ashley L Dey, Majid Motevalli, Isaac Abrahams, Peter B. Wyatt

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: X-ray structure; imidazolidine-2-one; amino acid; urea; phosgene

Online: 27 May 2024 (22:20:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0052.v1

Structure of Zn and Na Borophosphate Glasses by X-ray and Neutron Diffraction

Uwe Hoppe, Parker T. Freudenberger, Richard K Brow, Jozef Bednarcik, Alex C. Hannon

Subject: Chemistry And Materials Science, Ceramics And Composites Keywords: borophosphate glasses; short-range order; neutron diffraction; X-ray diffraction

Online: 1 May 2024 (07:15:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0880.v1

Chromosome Transplantation: Opportunities and Limitations

Angela La Grua, Ilaria Rao, Lucia Susani, Franco Lucchini, Elena Raimondi, Paolo Vezzoni, Marianna Paulis

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Chromosome Transplantation; Genomic Disease; X Chromosome; Duchenne Muscular Dystrophy; iPSC

Online: 15 March 2024 (10:10:00 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202312.1230.v1

Epstein-Barr Virus-negative Diffuse Large B Cell Lymphoma in a X-linked Severe Combined Immunodeficiency Patient: A Very Rare Condition

Dina Rochate, Sara Duarte, Rita S. Gomes, Rita Pinho Peixeiro, João Vaz Silva, Ângelo Rodrigues, Luís Leite, Rosa Branca, Sónia Lemos, Joana Guimarães, Susana Roncon, Ana Maia Ferreira, Carlos Pinho Vaz

Subject: Medicine And Pharmacology, Transplantation Keywords: DLBCL; X-linked SCID; allogeneic stem cell transplantation; infant; lymphoma

Online: 18 December 2023 (13:00:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0634.v1

Blackening Mechanism of Zn-Mg-Al Alloy Coated Steel Pre-pared by Water Vapor Treatment

Sang-hee Kim, You-jin Kang, Kyung-hwang Lee, Jun Kang, Myeong-hoon Lee, Yong-sup Yun

Subject: Chemistry And Materials Science, Surfaces, Coatings And Films Keywords: ZnO; ZnO1-x; Oxidation; Oxygen-deficient oxide; Optical bandgap energy

Online: 8 December 2023 (14:37:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1767.v1

Assessing the Impact of Genotype-by-Environment Interactions on Agronomic Traits in Elite Cowpea Lines Across Agro-ecologies in Nigeria

Bosede Olufunke Popoola, Patrick Obia Ongom, Saba B. Mohammed, Abou Togola, Daniel Jockson Ishaya, Garba Bala, Christian Fatokun, Ousmane Boukar

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Cowpea (Vigna unguiculata); G x E interactions; stability; GGE biplot

Online: 28 November 2023 (07:13:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1387.v1

Artificial Intelligence-Assisted Detection of Osteoporotic Vertebral Fractures on Lateral Chest Radiographs in Post-menopausal Women

Jenna Silberstein, Cleo Wee, Ashu Gupta, Hannah Seymour, Switinder Singh Ghotra, Claudia Sa Dos Reis, Zhonghua Sun

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: AI; spine fractures; diagnosis; thoracic X-ray; medical imaging; accuracy

Online: 22 November 2023 (08:46:51 CET)

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Post-menopausal women are at risk of osteoporotic vertebral fractures (OVFs), which if undetected and untreated, can lead to significant pain and morbidity. However, OVFs are often not reported by radiologists on routine chest radiographs. Artificial Intelligence (AI) is increasingly used in medical applications with improvements in detection and diagnosis. This study aims to investigate the clinical value of a newly developed AI tool, Ofeye 1.0 for automated detection of OVFs on lateral chest radiographs in post-menopausal women (>60 years) who were referred to undergo chest x-rays for other reasons. A total of 510 de-identified lateral chest radiographs from three clinical sites were retrieved and analysed by Ofeye1.0 tool. These images were then reviewed by a consultant radiologist to decide whether there is any fracture present or not with findings served as the reference standard for determining the diagnostic performance of the AI tool. The percentage of radiologist reports which included the OVF was analysed by comparing diagnostic reports with AI findings, while the accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive values (NPV) of the AI tool were calculated. Out of all the original radiologist reports, missed OVFs were found in 14% images but were detected by the AI tool. The AI tool demonstrated a relatively high specificity 92.8% (95% CI: 89.6, 95.2%), moderate accuracy 80.3% (95% CI: 76,3, 80.4%), PPV 73.7% (95% CI: 65.2, 80.8%) and NPV 81.5% (95%CI: 79, 83.8%), but low sensitivity 49% (95%CI: 40.7, 57.3%). The high false negative results were mainly due to mild OVFs with <20% vertebral height loss. The new AI software tool has high specificity with a low false positive rate of 5.1%, showing that it can be used as a complimentary tool to the routine diagnostic reports for reduction of missed OVF in elderly women. The low sensitivity with high false negative rates indicate the necessity of radiologist’s in identifying and reporting early OVFs.

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