The definition of a Smart-complex of educational discipline and its technology is given. Attention is focused on the form of the Smart-complex and constructive elements: the creative educational environment, the author's environment, the non-verbal environment, the encyclopedia, the creative / self-realization environment, the monitoring / self-evaluation environment.A feature of the Smart-complex of the academic discipline is the integration into it of the structural equalization block. Constructive alignment (alignment) is based on the design of the student's own learning participation in educational projects. Alignment refers to creating an appropriate learning environment and involves selecting the most appropriate training activities and evaluating each learning outcome. If the result of the training is to develop analytical skills, then for the assessment it is necessary to build questions and scenarios for their development.Two main components of the structural alignment are considered: 1) the first component is based on cognitive psychology and constructivist theory, recognizes the importance of linking new material with the concepts and experiences of students and extrapolation to possible future scenarios in the process of mission activity - they comprehend what they are doing during training; 2) the second component is based on the declaration by the teacher of the correspondence between the planned educational activities and the results of the training of students. This makes planning of educational activities and development of self-assessment criteria for organizing feedback. It is necessary to take into account the impact of Smart-complexes of educational disciplines on three think-tank training networks: 1) effective networks (why learn) - several ways of presenting to give students different ways of obtaining information and knowledge; 2) recognition networks (learning outcomes) - several ways of expressing them to provide them with an alternative for demonstrating what they know; 3) strategic exercises (how to learn) - several ways to increase the motivation for learning to attract their attention to both their own learning project and its technical and historical decision. Smart-complexes of educational disciplines should be: 1) scientific; 2) with user-friendly interface; 3) have a connection with LMS; 4) structured; 5) with visual material; 6) working in Off-line mode; 7) used on various devices in an educational institution, as well as at home.

Recently emerging data-driven citizen sciences need to harness increasing amount of massive data with varying quality. This paper develops essential theoretical frameworks and example models and examine its computational complexity for interactive data-driven citizen science within the context of guided self-organization. We first define a conceptual model that incorporates quality of observation in terms of accuracy and reproducibility, ranging between subjectivity, inter-subjectivity, and objectivity. Next, we examine the database's algebraic and topological structure in relation to informational complexity measures, and evaluate its computational complexities with respect to exhaustive optimization. Conjectures of criticality are obtained on self-organizing processes of observation and dynamical model development. Example analysis is demonstrated with the use of biodiversity assessment database, the process that inevitably involves human subjectivity for the management in open complex systems.

Purpose: Despite significant improvements in early detection of breast cancer, some patients still require mastectomy. One clinical problem currently being analyzed is the possibility of preserving the areola-nipple complex (NAC). The aim of this study was to evaluate the treatment results of breast cancer patients who underwent mastectomy with immediate breast reconstruction with sparing of the NAC. Methods: 335 patients who underwent mastectomy with breast reconstruction – with sparing (group I: 300 patients) or removal of NAC (group II: 35 patients), treated in the period 07.2014-06.2020. In the study groups, the length of overall survival (OS) and recurrence-free survival (RFS) were determined – up to 24 months after the end of treatment (short-term results) and up to 80 months (long-term results). The mean follow-up time of patients was 55.6 ± 19.7 months. Results: In 50 patients (14.9%), recurrence of neoplastic disease was observed (in group I: 14.7%, in group II: 17.1%; p=0.6972). It was most often a recurrence of cancer in the scar after mastectomy – in 25 patients (respectively: 7.7% vs 5.7%; p=0.6775) or distant metastases – in 16 patients (4.0% vs 11.4%; p=0.051). A total of 10 deaths were observed (6 – 2.0% vs 4 – 11.4%; p=0.0019). A total of 37 patients (10.7% vs 14.3%) required removal of their implant, mainly due to symptoms of infection – in 24 cases (7.3% vs 5.7%). Conclusion: Preserving the NAC is a safe therapeutic procedure in patients undergoing mastectomy with the option of reconstructive treatment. In both groups of patients, similar early and late treatment results were obtained.

In order to reduce the environmental impact of energy enterprises, it is important to promptly identify cases of possible changes in the quality of wastewater generated at power plants, that is cases of exceeding the maximum permissible concentrations of pollutants in wastewater. The goal of the method for detecting complex anomalies in multidimensional time series obtained from smart energy station’s sensor channels is to increase the accuracy of detecting pollution levels in industrial wastewater. To achieve this goal, the following tasks were solved: methods for detecting time series anomalies were analyzed, the method for detecting complex anomalies was developed, software implementation of the algorithm was carried out and experiments were conducted. The developed method is proposed to be used in an smart energy monitoring system.

In this paper, we introduce the notion of the generalized $w$-group inverse in a Banach algebra with proper involution. This is a natural generalization of generalized (weak) group inverse in Banach *-algebras. Many elementary properties of such new weighted generalized inverse are presented. We further establish the equivalent relations between generalized weighted group inverse and weighted generalized Drazin inverse. Related properties of generalized (weak) group inverse are extended to the wider cases.

This paper investigates the strategic dimensions influencing the adoption of environmental inno-vations (EIs) in small and medium-sized manufacturing enterprises (SMEs) in Mexico City. The study aims to understand the fundamental strategic dimensions defining eco-innovation and ex-amine how SMEs manage the complexities of incorporating these practices. Employing a mixed methods approach with documentary analysis and expert interviews; the study identifies key factors influencing EI adoption through causal maps and the Viable System Model. Findings high-light the significance of external and internal factors such as competitive pressure, economic con-straints, technological capabilities, political support, and social influence. This integrative approach emphasizes the importance of adaptability and responsiveness, presenting eco-innovation as a source of sustainable competitive advantage for SMEs.

The present study explored whether exposure to complex childhood trauma (CCT) is reflected in the resting-state electroencephalography (EEG) temporal alpha power of complex trauma-exposed adolescents, given the association of temporal alpha with fear circuitry (learning and conditioning) in a sample of 25 adolescents and similar controls, ages 12-17 years. Both trauma and psychopathology were screened or assessed, and resting-state EEG was recorded, following a preregistered protocol for data collection. Temporal alpha power, corresponding to T5 and T6 electrode location (10-20 international system), was extracted from resting-state EEG in both eyes-open and eyes-closed conditions. We found that in the eyes-open condition, right, but not left, temporal alpha was significantly higher in adolescents exposed to CCT, relative to healthy controls, suggesting that childhood trauma exposure may have a measurable impact on alpha oscillatory patterns, specifically in the right temporal region. Our study highlights the importance of considering neural markers, such as temporal alpha power, in understanding the long-term consequences of CCT exposure in developmental samples, with possible important clinical implications in guiding neuroregulation interventions.

To facilitate the promotion and application of the whole process engineering consulting (WPEC) model, the transmission mechanism of influencing factors in WPEC's promotion and application is investigated. It identifies and categorizes the influencing factors within the framework of "external environment-project factors-stakeholders", systematically organizing and summarizing ten primary categories and thirty-eight secondary influencing factors of WPEC's promotion and ap-plication. Utilizing the complex network analysis method, a network of influencing factors in the promotion and application of WPEC is constructed. The network is then converted into three binary networks based on weight, which are subjected to structural analysis and motif analysis. On this basis, the transmission mechanism of influencing factors in WPEC's promotion and applica-tion and its causations are explored.

The quality prediction of quaternary structure models of a protein complex, in the absence of its true structure, is known as the Estimation of Model Accuracy (EMA). EMA is useful for ranking predicted protein complex structures and using them appropriately in biomedical research, such as protein-protein interaction studies, protein design, and drug discovery. With the advent of more accurate protein complex (multimer) prediction tools, such as AlphaFold2-Multimer and ESMFold, the estimation of the accuracy of protein complex structures has attracted increasing attention. Many deep learning methods have been developed to tackle this problem; however, there is a noticeable absence of a comprehensive overview of these methods to facilitate future development. Addressing this gap, we present a review of deep learning EMA methods for protein complex structures developed in the past several years, analyzing their methodologies and impacts. We also provide a prospective summary of some potential new developments for further improving the accuracy of the EMA methods.

In this paper, corticosteroid–β-cyclodextrin (β-CD) inclusion complexes have been prepared by Supercritical AntiSolvent (SAS) precipitation to enhance the dissolution rate of dexamethasone (DEX) and prednisolone (PRED), which are poorly water-soluble drugs. The processing of the active principles in the absence of a carrier led to the almost complete extraction of the active principle (the small amount of obtained material precipitates in the form of crystals). The coprecipitation of the ingredients in the presence of β-CD was investigated at different concentrations, pressures, and molar ratios. For both the corticosteroids, the optimized operating conditions were 40 °C, 120 bar, an equimolar ratio, and a concentration in DMSO of 20 mg/mL; these conditions led to the attainment of microparticles with a mean diameter equal to 0.197±0.180 μm and 0.131±0.070 μm in the case of DEX and PRED, respectively. The Job’s method confirmed the formation of inclusion complexes in correspondence with the 1/1 mol/mol ratio. Compared to the pure ingredients, the obtained powders have an improved release rate, which is about 3 times faster in both cases.

We propose a notion of a ternary skew-symmetric covariant tensor of 3rd order, consider it as a 3-dimensional matrix and study a ten-dimensional complex space of these tensors. We split this space into a direct sum of two five-dimensional subspaces and in each subspace there is an irreducible representation of the rotation group SO(3)↪SO(5). We find two independent SO(3)-invariants of ternary skew-symmetric tensors, where one of them is the Hermitian metric and the other is the quadratic form. We find the stabilizer of this quadratic form and its invariant properties. Making use of these invariant properties we define a SO(3)-irreducible geometric structure on a five-dimensional complex Hermitian manifold. We study a connection on a five-dimensional complex Hermitian manifold with a SO(3)-irreducible geometric structure, find its curvature and torsion. The structures proposed in this paper and their study are motivated by a ternary generalization of the Pauli’s principle proposed by R. Kerner.

Prescriptions for fuels management are universally applied across forest types in British Columbia, Canada, to reduce fire behaviour potential in the wildland-urban interface. Fuel thinning treatments are assumed to reduce the potential for sustained ignition and crown fire initiation by reducing surface fuel loading. We hypothesized that these prescriptions are not appropriate for the coastal wet forests in the Whistler region of the province. Our study measured the efficacy of fuel thinning treatments in four stands located in the Whistler community forest. We examined several in-stand microclimate variables during snow melt in the spring and at the height of fire danger in late summer, at thinned and unthinned locations paired using GIS- analysis. We found that thinning increased the wildfire risk based on the differences between unthinned and thinned areas in the same forest stand.

Recently, a paper was written to establish semi-structured complex numbers ℍ (a new number set invented to enable division by zero) as a useful mathematical tool providing novel results from its application in engineering and science. Whilst the paper was a milestone, the application of this number set to quantum and classical physics had not been fully explored. Consequently, the aim of this research was to use semi-structured complex numbers to develop a new mathematical model for the mass of an object and in course unite classical and quantum physics in a simple yet effective manner. As its major contributions this paper: (1) develops a new mathematical model for the mass of an object called the wave-mass function using De Broglie’s mass and frequency relation and semi-structured complex numbers; (2) uses the new wave-mass function to determine what happens to an object traveling at the speed of light; (3) derives a relation between Schrödinger’s wave function and the new wave-mass function; (4) derives a relation between Einstein’s Field Equation and the new wave-mass function; (5) uses the wave-mass function to combine Einstein’s Field Equation with Schrödinger’s wave function to form a new quantum gravity equation. These results and their applications provide a firm foundation to advance the number set ℍ as a useful mathematical tool.

Complex-structured polymeric microparticles hold significant promise as advance in next-generation medicine mostly due to demand from developing targeted drug delivery. However, the conventional methods for producing these microparticles of defined size, shape and sophisticated composition often face challenges in scalability, reliance on specialized components such as micro-patterned templates, or have limited control over particle size distribution and cargo release kinetics. In this study, we introduce a novel and reliably scalable approach for manufacturing microparticles of defined structures and sizes with variable parameters. The concept behind this method involves the deposition of a specific number of polymer layers on a substrate with low surface energy. Each layer can serve as either the carrier for cargo or a programmable shell-former with predefined permeability. Subsequently, this layered structure is precisely cut into desired-sized blanks using a laser. The manufacturing process is completed by applying of heat to the substrate what results on sealing the edges of the blanks. The combination of the high surface tension of the molten polymer and the low surface energy of the substrate enables the formation of discrete particles, each possessing semi-spherical or other designed geometries determined by their internal composition. Such anisotropic microparticles are envisaged versatile applications.

In order to solve the problems of complicated steering control of unmanned vehicles in the field and difficult steering on complex roads, we designed a wheel-track composite vehicle equipped with a novel power differential steering mechanism with dual driving, which drove the steering of the vehicle through the differential rotation of the rear two wheels. The unmanned vehicle was simple to control, small in size, and able to work under the conditions of complex roads, such as hills, mountains, and muddy land. Firstly, a steering mechanism with both differential speed and force was designed to prevent the vehicle from skidding into muddy land and stopping motionless. Secondly, the kinematics model and dynamics model of the two drive shafts and the two output shafts (wheel shafts) were established. Thirdly, according to the relationship between the rotational speed of the two output shafts and the steering radius of the vehicle, the kinematic model of the rotational speed of the two input shafts and the steering radius of the wheel-track composite vehicle was obtained. Finally, according to the test data, the mathematical model of rotational speeds of the two input shafts and the actual steering radius of the vehicle was obtained by neural network fitting, and the maximum relative error between the model results and the actual steering radius value was 3.53%. The combination of power differential steering mechanism and wheel-track composite unmanned vehicle increased the adhesion with the ground and could better adapt to the complex road environment. In conclusion, the unmanned vehicle had the advantages of continuous radius steering, deceleration and torsion increase, differential lock, etc. It was suitable for all-terrain military and civilian vehicles and various special equipment mobile platforms of the walking device, and the research results could provide theoretical references for the steering control and structural optimization of the wheel-track composite vehicle under the environment of complex road surface.

In complex systems constrained by multiple factors, it is of great significance to accurately identify the key influencing factors for mastering the evolution and development law of the system and obtaining scientific decision-making suggestions or schemes. At present, the method based on experimental simulation is limited by the difficulty of system model construction; the method based on decision trial and Evaluation laboratory (DEMATEL) involves a wide range of subjects and is greatly influenced by subjective factors. In view of this, we propose a novel model based on heuristic causal inference. The model uses the FCI algorithm with prior knowledge to learn the global causal network among multiple factors of the complex system. The causal effect among variables in the causal network is calculated by using heuristic causal inference method. Specifically, the causal path contribution degree of cause variable to target variable is calculated to replace the causal effect of each cause variable to target variable. The key influencing factors in the system are screened out according to the contribution degree of causal pathways. Based on the dataset generated in the production process of a semiconductor manufacturing system, we carried out simulation experiments, identified several factors that have a key impact on product quality, and proved the feasibility and effectiveness of the proposed model.

This article presents a review of the distribution system state estimation (DSSE) algorithms from the model-based approach to the recent data-driven methodologies. The insufficient measurements which result in low observability have motivated the need to shift from the conventional algorithm to data-driven approaches that can successfully estimate states despite the DSSE challenges. This article discusses the nonlinearity in the DSSE problem formulation and how different model-based methods have been proposed to mitigate the problems of robustness, ill-conditioning, and complexity. Moreover, approximate DSSE to obviate nonlinearity were discussed: complex linearization, small angle approximation, convexification and compressed sensing. Furthermore, probabilistic DSSE methods were also discussed in the need to quantify the uncertainty associated with the state estimation results. Also, data-driven methods applicable to DSSE, pseudo measurement generations, and topology identification were also discussed using machine and deep learning methods. Lastly, a recent approach that employs a hybrid of model-based and data-driven methods using matrix and tensor completion is surfacing because they work in a low observable condition of the network and can estimate the states satisfactorily. With this review, researchers can look further into developing and improving on the model-based data-driven methods less susceptible to the barriers in conventional DSSE algorithms.

The COVID-19 pandemic has profoundly changed the world and human society in various ways. Infection-related figures are key indicators of the direct impact of the pandemic. In addition to the virus, many vulnerable populations (e.g. patients with complex health conditions) have suffered direct or indirect health impacts, such as delayed treatment or diagnosis of cancer and severe mental illness due to stay-at-home restrictions, or financial issues. Studying these kinds of impacts can provide the community with insights and understanding of how the pandemic has affected patients with health conditions and help inform decision-makers design policies that support various vulnerable populations. This paper surveys analytical work conducted on how COVID-19 has impacted patients with complex health conditions. We categorise vulnerable populations into three specific cohorts: patients with chronic disease, patients with cancer and patients with end-of-life care. We then investigate how each of these cohorts has been impacted by the pandemic. We also identify each cohort from an analytics perspective by leveraging various data collection strategies and analytical methods. The goals of this paper are to provide evidence on how to improve the quality of life for vulnerable populations and to inform a national response strategy for future pandemics, which seems inevitable in a highly globalised economy.

The natural compounds of boron have many applications, including as dietary supplement. Communication is based on the discovery that diester chlorogenoborate complex can be detected and quantified from green coffee bean. The study reports that such diester molecule can also be synthesized in stable form by direct reaction of boric acid and chlorogenic acid, in a mixture of acetonitrile–water (1:1, v/v), left to evaporate over a period of 48 hours, at room temperature, resulting a spirocyclic form (diester complex). The diester complex, with its molecular structure and digestibility attributes has potential application as prebiotic in gut health, oral health and as micronutrient essential for microbiota to human and animals.

The study shows that the volumes and surfaces of $n$-balls, $n$-simplices, and $n$-orthoplices are holomorphic functions of $n$, which makes those objects omnidimensional, that is well defined in any complex dimension. Applications of these formulas to the omnidimensional polytopes inscribed in and circumscribed about $n$-balls reveal previously unknown properties of these geometric objects. In particular, for $0 < n < 1$, the volumes of the omnidimensional polytopes are larger than those of circumscribing $n$-balls, and both their volumes and surfaces are smaller than those of inscribed $n$-balls. The surface of an $n$-simplex circumscribing unit diameter $n$-ball is spirally convergent to zero with real $n$ approaching negative infinity but first has a local maximum at $n=-3.5$. The surface of an $n$-orthoplex circumscribing unit diameter $n$-ball is spirally divergent with real $n$ approaching negative infinity but first has a local minimum at $n=-1.5$, where its real and imaginary parts are equal to each other; similarly, as its volume, where the similar local minimum occurs at $n=-3.5$. Reflection functions for volumes and surfaces of these polytopes inscribed in and circumscribed about $n$-balls are proposed. symmetries of products and quotients of volumes in complex dimensions $n$ and $-n$ and of surfaces in complex dimensions $n$ and $2-n$ are shown to be independent of the metric factor and the gamma function. Specific symmetries also hold between volumes and surfaces in dimensions $n = -1/2$ and $n = 1/2$.

Sacrococcygeal pilonidal disease is a chronic inflammatory condition with an incidence of 26:100,000 in the United States. However, its etiology and optimal treatment remain controversial. We included 129 and 74 patients with simple and complex sacrococcygeal pilonidal disease, respectively. The primary outcome was pilonidal sinus recurrence after unroofing curettage. Secondary outcomes were pain scores, time to return to work/school, and time to complete recovery. At a median follow-up of 53 months, the recurrence rate was 4.9% in all patients, not significantly higher in subjects with the complex disease. Duration of surgery (15.4 vs. 12.2 min), time to return to school/work (9.8 vs. 7.7 days), and complete healing time (44 vs. 36 days) were longer in patients with the complex disease. Postoperative complication rates, pain scores, and quality of life scores between the two groups did not differ. Unroofing curettage may be a good first-choice treatment for both simple and complex sacrococcygeal pilonidal disease.

This paper aims at addressing the exploitation of solid-state carriers for hydrogen storage, with attention paid both to the technical aspects, through a wide review of the available integrated systems, and to the social aspects, through a preliminary overview of the connected impacts from a gender perspective. As for the technical perspective, carriers to be used for solid-state hydrogen storage for various applications can be classified into two classes: metal and complex hydrides. Related crystal structures and corresponding hydrogen sorption properties are reviewed and discussed. Fundamentals of thermodynamics of hydrogen sorption evidences the key role of the enthalpy of reaction, which determines the operating conditions (i.e. temperatures and pressures). In addition, it rules the heat to be removed from the tank during hydrogen absorption and to be delivered to the tank during hydrogen desorption. Suitable values for the enthalpy of hydrogen sorption reaction for operating conditions close to ambient (i.e. room temperature and 1-10 bar of hydrogen) are close to 30 kJ·molH2 1. The kinetics of hydrogen sorption reaction is strongly related to the microstructure and to the morphology (i.e. loose powder or pellets) of the carriers. Usually, kinetics of hydrogen sorption reaction is rather fast, and the thermal management of the tank is the rate determining step of the processes. As for the social perspective, various scenarios for the applications in different socio-economic contexts of solid-state hydrogen storage technologies are described. As it occurs with the exploitation of other renewables innovative technologies, a wide consideration of the social factors connected to these processes is needed to assess the extent to which a specific innovation might produce positive or negative impacts in the recipient socio-economic system and to explore the potential role of the social components and dynamics in fostering the diffusion of the innovation itself. Attention has been addressed to the gender perspective, in view of the enhancement of hydrogen-related energy storage systems, intended both in terms of the role of women in triggering the exploitation of hydrogen-based storage as well as to the impact of this innovation in their current conditions, at work and in daily life.

Link prediction is an iconic problem in complex networks because deals with the ability to predict nonobserved existing or future parts of the network structure. The impact of this prediction on real applications can be disruptive: from prediction of covert links between terrorists in their social networks to repositioning of drugs in molecular diseasome networks. Here we compare: (1) an ensemble meta-learning method (Ghasemian et al.), which uses an artificial intelligence (AI) stacking strategy to create a single meta-model from hundreds of other models; (2) a structural predictability method (SPM, Lü et al.), which relies on a theory derived from quantum mechanics and does not assume any model; (3) a modelling rule named Cannistraci-Hebb (CH, Muscoloni et al.), which relies on one brain-bioinspired model adapting to the intrinsic network structure.We conclude that brute-force stacking of algorithms by AI does not perform better than (and is often significantly outperformed by) SPM and one simple brain-bioinspired rule such as CH. This agrees with the Gödel incompleteness: stacking is optimal but incomplete, you cannot squeeze out more than what is already in your features. Hence, we should also pursue AI that resembles human-like physical ‘understanding’ of simple generalized rules associated to complexity. The future might be populated by AI that ‘steals for us the fire from Gods’, towards machine intelligence that creates new rules rather than stacking the ones already known.

As for most Mediterranean countries, groundwater is the main resource for irrigation and drinking supply in most parts of Syria, however this resource suffers from mismanagement. In the study area (Northeast of Mt. Hermon), the lack of information makes water management in this area extremely difficult. Assessing groundwater pollution risk is the most essential issue for water resources management, especially in the regions where complex interaction between climate, geology, geomorphology, hydrogeology, water scarcity and water resource mismanagement exist. This complexity leads to significant complication in determining pollution risk of studied system. In the present work, we adopted an Integrative Approach to assess groundwater pollution risk in the study area. This methodology is based on the analysis of hydrogeological characteristic of aquifer system and the available information about socio-economic context and physio-chemical groundwater condition that might affect this system. This approach allowed us to delineate the groundwater pollution risk map based on the analysis of concerning parameters/ indicators. The degree of risk was assessed based as the sum and average of rating of these parameters and indicators for each subarea. Typically, very high pollution risk index was identified over the Quaternary/Neogene horizon, i.e shallow and unconfined aquifer and in the lower part of Jurassic aquifer. In these two parts, the majority of anthropogenic activities are concentrated. Low pollution risk index was found for the outcropping of low permeable Quaternary basalt at the Southern part of the study area. A moderate pollution index was identified for the low/moderate permeability of silt, clay and marly limestone rich horizons of the major part of Neogene aquifer outside of the intersected zones with Quaternary aquifer and for the Paleogene formations. The spatial analysis shows that about 50% of the study area is characterized as being at very high and high pollution risk index. Hence, the overall natural protective capacity of this area is still poor. This study demonstrates the flexibility of the proposed approach to assess groundwater pollution risk in local complex aquifer system characterized by lack of information and data in order to reduce the risk of future groundwater pollution.

Bacteria currently included in Rhizobium leguminosarum are too diverse to be considered a single species, so we can refer to this as a species complex (the Rlc). We have found 429 publicly available genome sequences that fall within the Rlc and these show that the Rlc is a distinct entity, well separated from other species in the genus. Its sister taxon is R. anhuiense. We constructed a phylogeny based on concatenated sequences of 120 universal (core) genes, and calculated pairwise average nucleotide identity (ANI) between all genomes. From these analyses, we concluded that the Rlc includes 18 distinct genospecies, plus 7 unique strains that are not placed in these genospecies. Each genospecies is separated by a distinct gap in ANI values, usually at around 96% ANI, implying that it is a 'natural' unit. Five of the genospecies include the type strains of named species: R. laguerreae, R. sophorae, R. ruizarguesonis, "R. indicum" and R. leguminosarum itself. The 16S ribosomal RNA sequence is remarkably diverse within the Rlc, but does not distinguish the genospecies. Partial sequences of housekeeping genes, which have frequently been used to characterise isolate collections, can mostly be assigned unambiguously to a genospecies, but alleles within a genospecies do not always form a clade, so single genes are not a reliable guide to the true phylogeny of the strains. We conclude that access to a large number of genome sequences is a powerful tool for characterising the diversity of bacteria, and that taxonomic conclusions should be based on all available genome sequences, not just those of type strains.

Calibrating ecological models or making decisions with them is an optimisation problem with challenging methodological issues. Depending on the optimisation formulation, there may be a large variety of optimisation configurations (e.g. multiple objectives, constraints, stochastic criteria) and finding a single acceptable solution may be difficult. The challenges are exacerbated by the high computational cost and the non linear or elusive mathematical properties that increased with the complexity of numerical models. From the feedbacks of practitioners, the need for a guideline for conducting optimisation of complex models has emerged. In this context, we propose a practical guide for the complex model optimisation process, covering both calibration and decision-making. The guide sets out the workflow with recommendations for each step based on existing tools and methods usually scattered throughout the literature. This guide is accompanied with an ODDO template (Overview, Design, Details of Optimisation) to standardise the published description of model-based optimisation and suggests research directions.

Background: Acute injuries of the hamstring muscle complex (HMC) Type 3b (interfascicle / bundle-tear) are frequently observed in various sports disciplines both in elite and recreational sport. The treatment of choice of acute HMC injuries Type 3b is a progressive physiotherapeutic exercise program. Besides this, there is currently only insufficient scientific evidence to support other treatment methods, including local infiltrations and injections of platelet-rich-plasma. Very recently it was demonstrated that extracorporeal shock wave therapy (ESWT) may accelerate regeneration after acute skeletal muscle injury. The aim of the present study is to test the hypothesis that the combination of radial ESWT (rESWT) and a specific rehabilitation program (RP) is effective and safe in treatment of acute HMC injury Type 3b in athletes, and is statistically significantly more effective than the combination of sham-rESWT and RP. Methods/Design: We will perform a double blind, randomized, sham-controlled clinical trial at the clinic KinEf Kinesiología Deportiva, Ciudad Autónoma de Buenos Aires, Argentina. Fourty patients with acute HMC injury Type 3b will be randomly allocated to receive either rESWT (nine rESWT sessions; three sessions per week; 2500 radial extracorporeal shock waves (rESWs) per session; energy density depending on what the patient tolerates) or sham-rESWT. In addition, all patients will receive a specific rehabilitation program that will last for eight weeks. The primary outcome measure will be the individual time (days) necessary to return to play. Secondary outcomes will include the presence or absence of reinjury during a time period of six months after inclusion into the study. Discussion: Because of the lack of adequate treatment options for acute HMC injury Type 3b in athletes and particularly the high reinjury rate, we hypothesize that the results of this trial will be of importance and have impact on clinical practice. Trial registration: ClinicalTrials.gov ID NCT03473899. Registered March 22, 2018.

The spatial formation of coherent random laser modes in strongly scattering disordered random media is a central feature in the understanding of the physics of random lasers. We derive a quantum field theoretical method for random lasing in disordered samples of complex amplifying Mie resonators which is able to provide self-consistently and free of any fit parameter the full set of transport characteristics at and above the laser phase transition. The coherence length and the correlation volume respectively is derived as an experimentally measurable scale of the phase transition at the laser threshold. We find that the process of stimulated emission in extended disordered arrangements of active Mie resonators is ultimately connected to time-reversal symmetric multiple scattering in the sense of photonic transport while the diffusion coefficient is finite. A power law is found for the random laser mode diameters in stationary state with increasing pump intensity.

Accurate repair of DNA is critical for genome stability and cancer prevention. DNA double-strand breaks are one of the most toxic lesions and can be repaired using homologous recombination (HR). HR is a high-fidelity DNA repair pathway that uses a homologous template for repair. One central HR step is RAD51 nucleoprotein filament formation on the single-stranded DNA ends, a step required for the homology search and strand invasion steps of HR. RAD51 filament formation is tightly controlled by many positive and negative regulators, collectively termed the RAD51 mediators. The RAD51 mediators function to nucleate, elongate, stabilize, and disassemble RAD51 during repair. In model organisms, RAD51 paralogs are RAD51 mediator proteins that structurally resemble RAD51 and promote its HR activity. New functions for the RAD51 paralogs during replication and in RAD51 filament flexibility have recently been uncovered. Mutations in the human RAD51 paralogs (RAD51B, RAD51C, RAD51D, XRCC2, XRCC3, and SWSAP1) are found in a subset of breast and ovarian cancers. Despite their discovery three decades ago, few advances have been made in understanding the function of the human RAD51 paralogs. Here we discuss the current perspective on the RAD51 paralogs in vivo and in vitro function and their relationship with cancer in vertebrate models.

We apply utilized the extended form of the auxiliary equation method to obtain extensively reliable exact travelling wave solutions of perturbed Gerdjikov–Ivanov equation (GIE) that is widely used as a model in the field theory of quanta and non-linear optics. The method is based on a simple first order second degree ODE. The new form of the approach gives more solutions to the governing equation efficiently.

This study aims to understand the current state of research in urban resilience and to open a discussion about multi-level perspectives for this concept. Starting with the history of the concept of resilience, we identify three main stages in resilience concept’s evolution: conceptualization, contextualization and operationalization. Confusion occurs between sustainability and resilience, therefore we clearly separate these two concepts by creating conceptual maps. Such maps also underline the specificities of urban and regional resilience discourses. We illustrate that urban resilience research, operating within intra-urban processes, is oriented towards natural disasters, while regional resilience research, operating mostly within inter-urban processes, is oriented towards economic shocks. We show that these two approaches to resilience – urban and regional – are complementary, and we propose to integrate them into a multi-level perspective. By combining these two discourses, we propose a multi-level approach to urban resilience that takes into account both top-down and bottom-up resistance processes. In the discussion section, we propose to take the panarchy perspective as a theoretical framework for multi-level urban resilience, that explains the interactions between different levels through adaptive cycles, relationships between which can help to explain urban resilience.

The purpose of this study is to investigate the moderating effect of technology configuration capability on the relationship between strategic flexibility and organizational performance through different stages of technological life cycle. Through the empirical research on the 439 Chinese high-tech organizations, it shows that a technological configuration capability has enhanced the effect of strategic flexibility to the organizational performance in the complex dynamic environment. However, the impact on the different stages of technological life cycle is different. In addition, this paper explored strategic flexibility on different stages of technological life cycle on the basis of empirical study.

Biocompatible polymeric materials with potential to form functional structures in association with different therapeutic molecules have a high potential for biological, medical and pharmaceutical applications. Therefore, the protective capability of the inclusion nano-Complex formed between the sodium salt of poly(maleic acid-alt-octadecene) and a β-lactam drug (ampicillin trihydrate) on the chemical, enzymatic and biological degradation was evaluated. PAM-18Na was produced and characterized as reported previously. The formation of polymeric hydrophobic aggregates in aqueous solution was determined, using pyrene as a fluorescent probe. Furthermore, the formation of polymer-drug nano-complexes was characterized by Differential Scanning Calorimetry-DSC, viscometric, ultrafiltration/centrifugation assays, zeta potential and size measurements by dynamic light scattering-DLS. The PAM-18Na capacity to avoid the chemical degradation was studied through stress stability tests. The enzymatic degradation was evaluated from a pure β-lactamase, while the biological degradation was determined by different β-lactamase producing Staphylococcus aureus strains. When ampicillin was associated with PAM-18Na, the half-life time in acidic conditions increased, whereas both the enzymatic degradation and the minimum inhibitory concentration decreased to a 90 and 75%, respectively. These results suggest a promissory capability of this polymer to protect the β-lactam drugs against chemical, enzymatic and biological degradation.

Based on the perspective of complex directed weighted network analysis, this paper constructs a static resilience evaluation framework for trade networks from two dimensions: structural resilience and node resilience. It studies the evolution of static resilience in the upstream, midstream, downstream, and recycling trade networks of global wood forest products from 2002 to 2021. The study finds that the total trade volume of global wood forest products has increased by 58.0%, 77.3%, 71.2%, and 77.2% in the upstream, midstream, downstream, and recycling sectors, respectively. The downstream trade network exhibits efficient information transmission and resource mobility capabilities. All four types of trade networks exhibit scale-free characteristics, with core countries such as China, the United States, and Germany playing a dominant role in the network and playing a crucial role in network robustness, but also increasing network vulnerability. In terms of unweighted assortativity, all four networks exhibit the characteristic of "small countries relying on hubs," while the weighted assortativity of the downstream network is positive, indicating enhanced network resilience. In terms of node resilience, countries exhibit significant differences and dynamic changes. China demonstrates strong resilience and adaptability, while the United States maintains its core position. China's influence in the downstream network has significantly increased, and India has rapidly emerged in the recycling network. To enhance network resilience, it is necessary to increase diversity and redundancy, establish effective emergency response mechanisms, and promote the diversification and green transformation of the supply chain.

The physical properties of a structure such stiffness although can be determined by some statical tests, the identification of damping parameter requires a dynamic test. In general, both theoretical prediction and experimental identification of damping are quite difficult. There are many different techniques available for damping identification, and each method gives a different damping parameter. The dynamic indentation method, rheometry, atomic force microscopy, and resonant vibration tests are commonly used to identify the damping of materials, including soft materials. While the viscous damping ratio, loss factor, complex modulus and viscosity are quite common to describe damping of materials, there are also other parameters such as the specific damping capacity, loss angle, half-power bandwidth, and logarithmic decrement to describe damping of various materials. Often one of these parameters is measured in practical applications and the measured damping parameter needs to be converted into another damping parameter for comparison purposes. In this review, the theoretical derivations of different parameters for the description and quantification of damping and their relationships, and the methods for damping identification are presented. The expressions for both high damping and low damping are included and evaluated. This paper could be a primary resource for damping research and teaching.

The research presented in the article is devoted to the study of the influence of phase compounds on the friability of the Fe-Si-Mn-Al complex alloy. The urgency of the problem lies in the development of technology for producing a non-scatterable alloy from manganese-containing ores and high-ash coals. The main goal of the work is to determine the range of alloy compositions and the resulting phases that affect the dispersibility of the alloy, which is critically important for its industrial implementation. Research methods include thermodynamic diagram analysis (TDA) using data on the standard enthalpy of formation of intermetallic compounds, as well as experimental tests in an ore-thermal electric furnace with a capacity of 200 kV*A. The results show that Fe-Si-Mn-Al complex alloys form a variety of silicide and aluminide phases, including intermetallic compounds and ternary systems, which is critical for understanding and controlling their physicochemical properties. When smelting a complex alloy, the content of leboite (Fe3Si7) in the Fe-Si-Mn-Al system plays a significant role. The development of smelting technology will be aimed at avoiding the FeSi2-Fe3Si7-F2(FeAl3Si2)-Mn11Si19 tetrahedron area. This approach to controlling the composition of a complex alloy is critical to ensuring its consistent friability properties in industrial applications. Thus, this work represents an important step in understanding the physical properties and stability of Fe-Si-Mn-Al complex alloys, which have potential for widespread use in metallurgical and other industrial applications.

Wicked problems, such as climate change, systemic poverty, and healthcare inequalities, rep- resent the most pressing and intractable challenges facing society today. We propose a novel approach that leverages complex systems theory as a comprehensive framework for understanding and tackling these challenges. By applying concepts such as state space analysis, attractors, and nonlinear dynamics, we offer a sophisticated toolkit for mapping the intricate web of interactions defining wicked problems and exploring potential interventions. Our approach moves beyond tradi- tional reductionist methods, embracing the inherent complexity and dynamism of these issues. We demonstrate how this framework can lead to more nuanced, adaptive, and effective strategies for addressing persistent societal problems. Despite the prevalence of wicked problems and the avail- ability of complex systems theory, practical applications of this approach remain uncommon. This paper aims to bridge this gap, illustrating the potential of complex systems theory to transform our engagement with intractable problems and pave the way for more robust, holistic solutions. By synthesizing insights from mathematics, physics, and social sciences, we present a transdisci- plinary approach that promises to revolutionize how we conceptualize and address society’s most challenging issues.

Amidst the escalating demands for efficient Intelligent Transportation Systems (ITS) management, the significance of accurate Origin-Destination (OD) data prediction has emerged as a paramount concern, given its indispensable role in the ITS domain. This paper introduces a groundbreaking integrated model, creatively fusing the unique strengths of Graph Convolutional Network (GCN), Residual Neural Network (ResNet), and Long Short-Term Memory Network (LSTM) into a single architecture, which we name GraphResLSTM, to exploit road segment average speed data for OD prediction. Compared with conventional road segment traffic volume data, average speed data is more readily available, significantly reducing the data accessibility barrier for OD prediction. We underscore the critical role of selection of key road segments and employs a combination of Entropy Weight Method and Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) to identify 41 representative road segments from the experimental road network. In the experimental phase, we simulate 86400000 seconds of traffic conditions, generating a total of 1440000 data records. Utilizing these simulated data, we design and conduct comparative experiments between models as well as data types. The results demonstrate that both the GraphResLSTM model and road segment average speed data outperform other models and data types notably in OD prediction tasks.

The result of the multidisciplinary collaboration of researchers from different areas of knowledge to validate a solar radiation model is presented. The MAPsol is a 3D local-scale adaptive solar radiation model that allows to estimate direct, diffuse and reflected irradiance for clear sky conditions. The model includes the adaptation of the mesh to complex orography and albedo, and considers the shadows cast by the terrain and buildings. The surface mesh generation is based on surface refinement, smoothing and parameterisation techniques and allows the generation of high quality adapted meshes with a reasonable number of elements. Another key aspect of the paper is the generation of a high-resolution digital elevation model (DEM). This high-resolution DEM is constructed from LiDAR data and its resolution if two times more accurate than the publicly available DEMs. The validation process uses direct and global solar irradiance data obtained from pyranometers at the University of Salamanca located in an urban area affected by systematic shading from nearby buildings. This work provides an efficient protocol for studying solar resources, with particular emphasis on areas of complex orography and dense buildings where shadows can potentially make solar energy production facilities less efficient.

Background: As a relatively high number of ST-segment elevation myocardial infarction (STEMI) patients develop major adverse cardiovascular events (MACE) following percutaneous coronary intervention (PCI), our aim was to determine the significance, and possible predictive value of QRS complex width and ST-segment elevation. Methods: Our patient sample included 200 PCI-treated STEMI patients, which were divided into two groups, based on the duration of symptoms: (I) less than 6 hours, and (II) 6-12 hours. For every patient, ECG was performed at 6 different time points. Long-term follow-up lasted 6 years from the STEMI onset. Statistical analysis was performed. Results: The mean age was 60.6±11.39 years, and 142 were male. Wider QRS complex, more pronounced ST-segment elevation, and more frequently absent ST-segment resolution were more common in the second group. Presentation of MACE was more frequent in this group. An increase of pre-PCI QRS complex width by 1 msec increases the risk of 6-year MACE by 3%, and an increase in pre-PCI ST-segment elevation by 1mm increases the risk of 6-year MACE by 3.26 times. Conclusion: To the best of our understanding, this study represents a pioneer research that utilized these ECG elements in the context of predicting a 6-year MACE. A wider QRS complex and a more pronounced ST-segment elevation were associated with longer total ischemic time. More research is needed to confirm these findings.

Surface roughness prediction is a pivotal aspect of the manufacturing industry, as it directly influences product quality and process optimization. This study introduces a predictive model for surface roughness in the turning of complex-structured workpieces, utilizing Gaussian Process Regression (GPR) informed by vibration signals. The model captures parameters from both the time and frequency domains of the turning tool, encompassing the mean, median, standard deviation (STD), and root mean square (RMS) values. The signal is from the time to frequency domain is executed using Welch's method, complemented by time-frequency domain analysis employing three levels of Daubechies Wavelet Packet Transform (WPT). The selected features are then utilized as inputs for the GPR model to forecast surface roughness. Empirical evidence indicates that the GPR model can accurately predict the surface roughness of turned complex-structured workpieces. This predictive strategy has the potential to improve product quality, streamline manufacturing processes, and minimize waste within the industry.

In this work we study the intersection properties of a finite disk system in the euclidean space. We accomplish this by utilizing subsets of spheres with varying dimensions and analyze specific points within them, referred to as poles. Additionally, we introduce two applications: estimating the common scale factor for the radii that makes the re-scaled disks intersects in a single point, this is the \v{C}ech scale, and constructing the minimal Axis-Aligned Bounding Box (AABB) that encloses the intersection of all disks in the system.

The gold(I) N-heterocyclic carbene (NHC) complexes, containing a combination of 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene (iPr) and the corresponding 7-azaindole derivative (HL1-4), were prepared and structurally characterized. The complexes of the composition of [Au(iPr)(HLn)], where n = 1–4 for 5-fluoro-7-azaindole (1), 5-bromo-7-azaindole (2), 3-chloro-7-azaindole (3) and 3-iodo-7-azaindole (4), were further evaluated for their in vitro anti-cancer and anti-inflammatory activities. The results showed that complexes (1–4) behave as considerably cytotoxic against human ovarian cancer cell line A2780 (with IC50 = 4–9 mircoM) and cisplatin-resistant cell line A2780R (with IC50 = 5–8 microM, except for 2 with IC50 > 25 microM), providing significantly higher cytotoxicity than anticancer drug cisplatin. Moreover, they also revealed a relatively good selectivity over normal cells (MRC-5), with the values of selectivity index, SI > 2.5. The complex 4 was further studied for its cellular effects in A2780 cells by cell cycle analysis, induction of apoptosis, intracellular ROS production, activation of caspases 3/7 and disruption of mitochondrial membrane potential. The ability of complexes (1–4) to influence the activity of pro-inflammatory transcription factor NF-κB and secretion of TNF-α were evaluated, showing that complex 4 reveals comparable effects as the inflammatory drug Auranofin.

Robot workpiece machining is interesting in industry since it offers some advantages, such as higher flexibility in comparison with the conventional approach based on the CNC technology. However, in recent years we have been facing a strong progressive shift to custom based manufacturing and low volume/high mix production, which require a novel approach to automation by the employment of collaborative robotics. However, collaborative robots feature only limited motion capability, to provide safety in cooperation with human workers. Thus, it is highly necessary to perform more detailed robot task planning to ensure its feasibility and optimal performance. In this paper, we deal with the problem of studying kinematic robot performance in the case of such manufacturing tasks, where the robot tool is constrained to follow the machining path embedded on the workpiece surface at a prescribed orientation. The presented approach is based on the well-known concept of manipulability, although the latter suffers from physical inconsistency due to mixing different units of linear and angular velocity in a general 6 DOF task case. Therefore, we introduce the characteristics of the workpiece surface constraint in the robot kinematic analysis, that enables evaluation of its available velocity capability in a reduced dimension space. Such constrained robot kinematics transform the robot`s task space to a two-dimensional surface tangent plane, and the manipulability analysis may be limited to the space of linear velocity only. Thus, the problem of physical inconsistency is avoided effectively. We show the theoretical derivation of the proposed method, which was verified by numerical experiments.

This comprehensive review explores the principles, applications, and future directions of human-powered energy generation technologies. It begins by providing a detailed examination of viable human energy sources, elucidating the physical principles behind various energy harvesting devices. The review then compiles and assesses existing products in the field of human power generation, while also outlining the opportunities and challenges it presents. Finally, an innovative concept of an eco-village system is introduced to demonstrate a future potential application scenario for human-generated electricity. It outlines two developmental stages for this system and underscores its significance in the construction of the harmonious and sustainable communities. This forward-thinking approach could pave the way for broader discussions on sustainable living and eco-friendly energy generation in a world increasingly focused on environmental concerns and social stability.

Analytics have become increasingly popular among sports in recent years, providing valuable information regarding physical and mental health. Many athletes have found that analytics during training can help to improve their performance, reduce the risk of injury, and enhance their overall well-being. This paper aims to improve the results of handball players by applying a method for measuring the influence of different trials on aggregate performance calculated per each athlete in order to qualify for the Olympic Games. By separating the isolated action of each trial, the result is an additional influence caused by the interaction of factors or the simultaneous action. That might explain why the neuromuscular feedback loop is utterly necessary to perform handball motor actions. Further on, the ML analysis can help identify areas for improvement, optimize training programs, and enhance overall team performance.

Non-alcoholic steatohepatitis (NASH) is a complex disease resulting from chronic liver injury associated with obesity, type 2 diabetes, and inflammation. Recently, multi-target drugs have been proposed to treat complex diseases including NASH; however, their manufacturing pro-cesses remain time- and cost-intensive and inefficient. Therefore, to overcome these limitations, we developed UniStac, a novel enzyme-mediated conjugation platform for multi-specific drug development. UniStac demonstrated high conjugation yields, optimal thermal stabilities, and robust biological activities. Through such platform, we designed a tetra-specific compound, C-192, targeting Glucagon-like peptide 1 (GLP-1), Glucagon (GCG), Fibroblast growth factor 21 (FGF21), and Interleukin-1 receptor antagonist (IL-1RA) simultaneously for the treatment of NASH. The biological activity and treatment efficacy of C-192 were confirmed both in vitro and in vivo using a methionine–choline-deficient (MCD) diet-induced mouse model. C-192 exhibited profound therapeutic efficacies compared to conventional drugs, including liraglutide and dulaglutide. C-192 significantly improved alanine transaminase levels, triglyceride accumula-tion, and the non-alcoholic fatty liver disease activity score. Our results collectively provide clin-ical feasibility of UniStac for developing multi-specific drugs, and C-192 as an innovative thera-peutic opportunity for severe NASH, as it exerts synergistic effects across multiple targets.

: The article examines the regularities of structure formation of ultrafine fibers based on poly-3-hydroxybutyrat under the influence of technological (electrical conductivity, viscosity), molecular (molecular weight), and external factors (low-molecular and nanodispersed substances of different chemical nature). Systems with polar substances are characterized by the presence of intermolecular interactions and the formation of a more perfect crystalline fiber structure. Changes in technological and molecular characteristics affect the fiber formation process, resulting in alterations in the morphology of the non-woven fabric, fiber geometry, and supramolecular fiber structure. Polymer molecular weight, electrical conductivity, and solution viscosity influence fiber formation and fiber diameter. The fiber structure is heterogeneous, consisting of both crystalline and non-equilibrium amorphous phases. This is significant in the development of matrix-fibrillar systems for drug delivery, bioactive substances, antiseptics, tissue engineering constructs, tissue engineering scaffolds, artificial biodegradable implants, sorbents, and other applications.

In this paper, we succeed to discover the new exact wave solutions to the truncated M-fractional complex three coupled Maccari’s system by utilizing the Sardar sub-equation scheme. The obtained solutions are in the form of trigonometric and hyperbolic forms. These solutions have many applications in nonlinear optics, fiber optics, deep water-waves, plasma physics, mathematical physics, fluid mechanics, hydrodynamics and engineering where the propagation of nonlinear waves is important. Achieved solutions are verified with the use of Mathematica software. Some of the achieved solutions are also described graphically by 2-dimensional, 3-dimensional and contour plots with the help of Maple software. The gained solutions are helpful for the further development of concerned model. Finally, this technique is simple, fruitful and reliable to handle the nonlinear FPDEs.

We consider a coded compressed sensing protocol for unsourced massive random access (URA) that concatenates a shared Patterned Reed-Muller (PRM) inner codebook to an outer error-correction code. In this paper, an iterative list PRM projection algorithm is proposed to supplant the signal detector associated with the inner PRM sequences. In particular, we first propose an enhanced paths-saving algorithm called list PRM projection detection for the single-user scenario that keeps multiple candidates for the first few layers to remedy the risk of spreading errors. On this basis, we further propose an iterative list PRM projection algorithm for the multi-user scenario. The vectors for PRM codes and channel coefficients are jointly detected in an iterative manner, which offers significant improvements regarding the convergence rate for signal recovery. Furthermore, the performances of the proposed algorithms are analyzed mathematically, and we verified that the theoretical simulations are consistent with the numerical simulations. Finally, we concatenate the inner PRM codes that employ the iterative list detection to two practical error-correction outer codes. According to the simulation results, we conclude that the packetized URA with the proposed iterative list projection detection works better than benchmarks in terms of the number of active users it can support in each slot and the amount of energy needed per bit to meet an expected error probability.

Sepsis is a major health problem and accounts for 20 per cent of deaths worldwide. It is the most expensive condition treated in United States hospitals at $27 billion per year or about $20,000 per patient. Treatment consisting largely of fluid resuscitation and antibiotics has only marginal impact. Mortality is about 27 per cent for hospitalized patients and about 42 per cent for patients in intensive care.There are two phases of sepsis – a hyper inflammatory phase and a subsequent hypo inflammatory phase.During the hyper inflammatory phase the metabolic rate increases associated with an increase in body temperature and a rapid escalation of immune system functioning including increased numbers of leucocytes and migration of those leucocytes to infected and damaged tissues and an increased supply and consumption of glucose to fuel this immune system.During the subsequent hypo inflammatory phase the metabolic rate declines and this is associated with a decrease in body temperature and a generalized decrease in the physiological activity of many organs including the immune system akin to hibernation. The activated immune system has priority for the available glucose over most other organs and physiological functions during such potentially life threatening circumstances. Thus adenosine triphosphate (ATP) production by mitochondria (the source of energy at the cellular level for the organism as a whole) also has a lower priority for the available glucose relative to the activated immune system. If glucose availability is threatened then mitochondrial production of ATP is partially or substantially suppressed in favor of glycolysis because glycolysis can rapidly produce large quantities of ATP that are necessary for immune cell function in infected, anaerobic, ischemic, or damaged tissues.However, glycolysis is only a temporary fix as it cannot produce the quantities of ATP necessary on an ongoing basis for the normal functioning of the healthy animal. Mitochondrial production of ATP must be recommenced for full recovery.It appears that the partial or substantial suppression of mitochondrial production of ATP by activation of the immune response becomes relatively fixated in some patients leading to a substantial ATP deficit. This is the fundamental issue of sepsis.This paper reviews the metabolism of glucose and insulin during sepsis and concludes that high dose insulin with mild hyper glycaemia in conjunction with the intravenous administration of thiamine, an inhibitor of the pyruvate dehydrogenase kinase enzymes, to re-establish physiological ATP production by mitochondria, administered early in the hypo metabolic (hypo inflammatory) phase of sepsis should significantly improve survival.

To determine the metamorphic ages of the accretionary complexes in the Northern Chichibu Belt in SW Japan, K–Ar dating was conducted using weakly metamorphosed sedimentary rocks collected from the Kanto Mountains, Central Japan. Whole-rock ages were obtained for chert and red shale samples, and the mineral ages of fine-grained illite with the grain size less than 4 μm were obtained for chert, red shale, mudstone, acidic tuff, and basic tuff. The K–Ar ages of chert and red shale presented large variations, with systematically older ages compared to those of mudstone and tuff in the same strata. The influence of submarine hydrothermal activities on chert and red shale before subduction is a possible cause of this deviation. The illite samples, which were fractionated into four grain-size classes using a suspension method, yielded older ages and higher illite crystallinity (i.e., smaller values of Kübler’s crystallinity index) for larger grain-size classes. The peak metamorphic ages were determined from the K–Ar ages of the 3–4 μm class illite in mudstone and tuff. The Late Jurassic to the Earliest Cretaceous accretionary complex of the lowest structural unit (Kashiwagi Unit) was dated within a small range between 117–110 Ma, which is distinctly older than the K–Ar ages of white mica reported from the Sanbagawa Belt. The peak metamorphic age of acidic tuff (113 Ma) at the type locality of the Mikabu Greenstones indicates that the subducted Mikabu seamount is a constituent of the Kashiwagi Unit. The peak metamorphic ages of the Manba and Kamiyoshida Units were obtained as 132–107 Ma and 163–144 Ma, respectively. Major structural discontinuity is suggested within the Middle Jurassic accretionary complexes.

In recent years, due to the advancement of machine learning, object detection has become a mainstream task in the computer vision domain. The first phase of object detection is to find the regions where objects can exist. With the improvement of deep learning, traditional approaches such as sliding windows and manual feature selection techniques have been replaced with deep learning techniques. However, object detection algorithms face a problem when performing in low light, challenging weather, and crowded scenes like any other task. Such an environment is termed a challenging environment. This paper exploits pixel-level information to improve detection under challenging situations. To this end, we exploit the recently proposed hybrid task cascade network. This network works collaboratively with detection and segmentation heads at different cascade levels. We evaluate the proposed methods on three complex datasets of ExDark, CURE-TSD, and RESIDE and achieve an mAP of 0.71, 0.52, and 0.43, respectively. Our experimental results assert the efficacy of the proposed approach.

β-cyclodextrin (CD) derivatives containing aromatic triazole ring were studied as potential carriers of drugs containing an anthraquinone moiety in the structure: anthraquinone-2-sulfonic acid (AQ2S), anthraquinone-2-carboxylic acid (AQ2CA) and a common anthracycline, daunorubicin (DNR). UV-Vis and voltammetry measurements were carried out to determine the solubilities and stability constants of the complexes formed and revealed the unique properties of the chosen CDs as effective pH dependent drug complexing agents. The stability constants of the drug complexes with the CDs containing triazole: βCDLip and βCDGAL were significantly larger than with the native βCD. The AQ2CA and AQ2S drugs are ill-soluble and their solubilities increased as the result of complex formation with βCDLip and βCDGAL ligands. AQ2CA, AQ2S were negatively charged at pH 7.4 and therefore they were less prone to form inclusion complex with the hydrophobic CD cavity than at pH 3 (characteristic of gastric juices) when they were protonated. βCDTriazole and βCDGAL ligands were found to form weaker inclusion complexes with the positively charged drug DNR at acidic pH (pH 5.5) than in the neutral medium (pH 7.4) when the drug dissociates to the neutral, uncharged form. This pH dependence is favorable for anti-tumor applications.

The strong couplings among ecological, economic, social and technological processes explains the complexification of human-made systems, and phenomena such as globalization, climate change, the increased urbanization and inequality of human societies, the power of information, and the COVID-19 syndemics. Among complexification’s essential features are non-decomposability, asynchronous behavior, components with many degrees of freedom, increased likelihood of catastrophic events, irreversibility, nonlinear phase spaces with immense combinatorial sizes, and the impossibility of long-term, detailed prediction. Sustainability for complex systems implies enough efficiency to explore and exploit their dynamic phase spaces and enough flexibility to coevolve with their environments. This in turn means solving intractable nonlinear semi-structured dynamic multi-objective optimization problems, with conflicting, incommensurable, non-cooperative objectives and purposes, under dynamic uncertainty, restricted access to materials, energy and information, and a given time horizon, aiming at enhancing the co-evolutionary power of the Biosphere and its human subsystems. Giving the high-stakes, the need for effective, efficient, diverse solutions, their local-global, present-future effects, and their unforeseen short, medium and long-term impacts, achieving sustainable complex systems implies the need for Sustainability-designed Universal Intelligent Agents, harnessing the strong functional coupling between human, artificial and nonhuman biological intelligence in a no-zero-sum game to achieve sustainability.

The fusion of "innovation theory" and "ecology" gave birth to a large number of studies on "innovation ecology", which mainly studies how to build an industrial ecological chain at the regional level, focusing on self-evolution, achieving ecological balance, and enabling the regional economy to take the path of sustainable innovation. This type of research borrows a lot of concepts from ecology, and very vividly describes the competition and cooperation relationships formed by various agents in the innovation system, laying a good foundation for qualitative analysis of the inherent dynamics of innovation development. However, many studies focus on the analogous description of ecosystems and economic systems, lacking scientifically and rigorously quantitative empirical research as a support. This paper uses network-based indicators such as degree, cluster coefficient, and betweenness centrality to measure the function and position of high-tech enterprises in the Z-Park in a business environment, so as to clarify the socio-economic meaning of the topological structure of the regional innovation system. On this basis, it provides theoretical references for regional innovation development and sustainable development policy formulation.

The connection of two phenomena - non-conservative friction forces and dissipation-induced instability can lead to many interesting engineering problems. The paper studies general material-dependent damping influence on dynamical instability of disc brake systems leading to brake squeal. The effect of general damping is demonstrated on a minimal and complex model of a disc brake. A complex system including material-dependent damping is defined in the commercial finite element software. The finite element model validated by experimental data on the brake-disc test bench is used to compute the influence of a pad and a disc damping variations on system stability by complex eigenvalue analysis. Analyzes show a significant sensitivity of the experimentally verified unstable mode of the system to the ratio of the damping between the disc and the friction material components.

Our earlier work has tentatively shown that the hierarchy of fermion masses and mixing angles follows from the universal behavior of nonlinear dynamics. In this brief sequel we survey a similar scenario in which the Cabibbo angle arises from the nonlinear dynamics of charged-current interactions.

The nature of the sustainability crisis is characterized by high levels of complexity, thus it is not amenable to be approached from the linearity or reductionist paradigm. Emergence is a multilevel phenomenon that is characterized by qualitative novelty and is recognized as an important attribute of complex systems produced by self-organized processes, unveiled from a holistic stance. This conceptual-analytical article explores the emergence phenomenon and questions whether it can be a way of enhancing the solution process to meet the sustainability challenges. Emergent properties or behaviors emerge only when the system parts interact in a wider whole. Moreover, a systemic approach is proposed as an intermediary component in the process of emergence of creative and wise solutions to the wicked problems of unsustainability. This requires observation and entails analyzing open systems as a whole and recognizing the impact of traversing macro- and micro- scales on causal and creative emergence. The study also emphasizes synergies between emergence and creativity aimed at sustainability. Sustainable development requires leapfrogging past conventional practices, in an accelerated way, and the emergence phenomenon at play between systems levels, coupled with purposefully structured creative processes, holds the potential for catalyzing sustainable development efforts.

The importance of antibodies in health care and the biotechnology research and development demands not only knowledge of their experimental structures at high resolution, but also practical implementation of this knowledge for both effective and efficient design and production of antibody for its use in both medical and research applications. While the experimental wet-lab approach is usually costly, laborious and time-consuming, computational (dry-lab) approaches, in spite of their intrinsic limitations in comparison with its experimental (wet-lab) counterpart, provide a cheaper and faster alternative option. For the first time, this article reports a comprehensive set of structural electrostatic features extracted from experimentally determined antigen-antibody-related structures, including especially those structural electrostatic features at the interfaces of all experimentally determined antigen-antibody complex structures as of February 29, 2020, to facilitate effective and efficient machine learning-based computational antibody design using currently available experimental structures inside Protein Data Bank.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a devastating illness whose biomedical basis is now beginning to be elucidated. We reported previously that, after recovery from frozen storage, lymphocytes (peripheral blood monocytic cells, PBMCs) from ME/CFS patients die faster in culture medium than those from healthy controls. We also found that lymphoblastoid cell lines (lymphoblasts) derived from these PBMCs exhibit multiple abnormalities in mitochondrial respiratory function and signalling activity by the cellular stress-sensing kinase TORC1. These differences were correlated with disease severity, as measured by the Richardson and Lidbury Weighted Standing Test. The clarity of the differences between these cells derived from ME/CFS patient blood and those from healthy controls suggested that they may provide useful biomarkers for ME/CFS. Here we report a preliminary investigation into that possibility using a variety of analytical classification tools, including linear discriminant analysis, logistic regression and Receiver Operating Characteristic (ROC) curve analysis. We found that results from three different tests, lymphocyte death rate, mitochondrial respiratory function and TORC1 activity could each individually serve as biomarker with better than 90% sensitivity but only modest specificity vís a vís healthy controls. However, in combination they provided a cell-based biomarker with sensitivity and specificity approaching 100% in our sample. This level of sensitivity and specificity was almost equalled by a suggested protocol in which the frozen lymphocyte death rate was used as a highly sensitive test to triage positive samples to the more time consuming and expensive tests measuring lymphoblast respiratory function and TORC1 activity. This protocol provides a promising biomarker that could assist in more rapid and accurate diagnosis of ME/CFS.

Interaction of an electromagnetic field with matter in a laser cavity without the assumption of a fixed direction of the transverse electric field, described by the two-level Maxwell-Bloch equations, is studied. By using a perturbative nonlinear analysis, performed near the laser threshold, we report on the derivation of the laser (3+1)D vectorial complex cubic-quintic complex Ginzburg-Landau equation. Furthermore, we study the modulational instability of the plane waves both theoretically using the linear stability analysis, and numerically, using direct simulations via the split-step Fourier method. The linear theory predicts instability for any amplitude of the primary waves. Our numerical simulations confirm the theoretical predictions of the linear theory as well as the threshold of the amplitude of perturbations. The system understudy shows a deep dependence on the laser cavity parameters, for which there appear wave patterns in accordance with the predictions from the gain spectrum.

Mediterranean coastal lagoons and their peripheral areas often provide a collection of habitats for many species, and they often face significant threats from anthropogenic activities. Diverse human activities in such areas directly affect the spatio-temporal dynamic of surface water and its ecological characteristics. Monitoring the surface water dynamic, and understanding the impact of human activities are of great significance for coastal lagoon conservation. The Regional Natural Park of Narbonne includes a typical Mediterranean lagoon complex where surface water dynamic and its potential link with local diverse human activities has not yet been studied. In this context, based on all the available Landsat images covering the study area during 2002-2016, this study identified the water and non-water classes for each satellite observation by comparing three widely used water indices (i.e., NDVI, NDWI and MNDWI) and using the Otsu method. The yearly water frequency index was then computed to present the spatio-temporal dynamic of surface water for each year, and three water dynamic scenarios were also identified for each year: permanent water (PW), non-permanent water (NPW) and non-water (NW). The spatial and inter-annual variation in the patterns of the three water scenarios were characterized by computing the landscape metrics at scenario-level quantifying area/edge, shape, aggregation and fragmentation. Finally, the quantitative link between different land use and land cover (LULC) types derived from the LULC maps of 2003, 2012 and 2015 and the surface water dynamic scenarios was established in each of the 300 m x 300 m grid cells covering the study area to determine the potential impact of human activities on the surface water dynamic. In terms of the inter-annual variation during 2002-2016, PW presented an overall stability, and NPW occupied only a small part of the water surface in each year and presented an inter-annual fluctuation. NPW had a smaller patch size, with lower connectivity degree and higher fragmentation degree. In terms of spatial variation during 2002-2016, NPW often occurred around PW, and its configurational features varied from place to place. Moreover, PW mostly corresponded to natural lagoon, and salt marsh (as a part of lagoons), and NPW had a strong link with arable land (agricultural irrigation) and salt marsh (salt production), sand beach/dune, coastal wetlands and lagoon for the LULC maps of 2003, 2012 and 2015. However, more in-depth analysis is required for understanding the impact of sand beach/dune, coastal wetlands and lagoon on surface water dynamics. This study covers the long-term variations of surface water patterns in a Mediterranean lagoon complex having intense and diverse human activities, and the potential link between LULC types and the water dynamic scenarios was investigated on different dates. The results of the study should be useful for environmental management and protection of coastal lagoons.

This work presents some characteristics of MoNet, a computerized platform for the modeling and visualization of complex systems. Emphasis is on the ideas that allowed the successful progressive development of this modeling platform, which goes along with the implementation of applications to the modeling of several studied systems. The platform has the capacity to represent different aspects of systems modeled at different observation scales. This tool offers advantages in the sense of favoring the perception of the phenomenon of the emergence of information, associated with changes of scale. Some criteria used for the construction of this modeling platform are included. The power of current computers has made practical representing graphic resources such as shapes, line thickness, overlaying-text tags, colors and transparencies, in the graphical modeling of systems made up of many elements. By visualizing diagrams conveniently designed to highlight contrasts, these modeling platforms allow the recognition of patterns that drive our understanding of systems and their structure. Graphs that reflect the benefits of the tool regarding the visualization of systems at different scales of observation are presented to illustrate the application of the platform.

By using the new recently proposed extended rational methods, we set some solitary and multi wave solutions of the coupled Higgs system in the present study. Some new families of hyperbolic and trigonometric solutions of the coupled Higgs equations are successfully obtained. Some solutions are real as some are complex valued functions. Particular forms of some solutions derived by choice of some parameters are demonstrated in three dimensional spaces. The complex valued solutions are also depicted by plotting both real and complex component.

We propose a notion of $(q,\sigma,\tau)$-differential graded algebra, which generalizes the notions of $(\sigma,\tau)$-differential graded algebra and $q$-differential graded algebra. We construct two examples of $(q,\sigma,\tau)$-differential graded algebra, where the first one is constructed by means of generalized Clifford algebra with two generators (reduced quantum plane), where we use a $(\sigma,\tau)$-twisted graded $q$-commutator. In order to construct the second example, we introduce a notion of $(\sigma,\tau)$-pre-cosimplicial algebra.

Low-frequency electron paramagnetic resonance (EPR) is used to extract the EPR parameter A-mid and support the approximate X-band value of g-mid for Ba(Co_yZn_1/3-yTa_2/3)O₃. Although cobalt hyperfine structure for the [+/−1/2> state is often unresolved at X-band or S-band, it is resolved in measurements on this compound. This allows for detailed analysis of the molecular orbital for the [+/−1/2> state, which is often the ground state. Moreover, this work shows that the EPR parameters for Co substituted into Zn compounds gives important insight into the properties of zinc binding sites.

We explore several ways, in order to include fermionic structures naturally in a physical theory in C⁴. We begin with the standard Dirac formalism and we proceed by using Cartan's property of triality as a second option. Afterwards, we suggest a new approach (in a preliminary basis), by introducing an 1-linear form, as the "square root of the geometry" derived by the usual 2-linear forms (quadratic forms). Keeping this way, we introduce n-linear forms, in order to formulate a new geometric structure, which could be suitable for the formulation of a pure geometric unied theory.

We explore the possibility to nd the usual quantum theories, within the formulation of a classic theory of mechanics in C⁴. Specically, by releasing the end-point of the integral of the action derived in C⁴, we derive the dynamic path length of the geodesic equation in C⁴. In the at case, the derived Hamilton-Jacobi equations, were identied as the usual Klein-Gordon equation, where the complex functional action S(z_i), is identied as the usual complex scalar field φ. Afterwards, we study the energy-momentum 4-d complex vector, in order to re-establish the usual covariant derivative of gauge theories.

In the paper, the authors survey integral representations (including the Lévy--Khintchine representations) and applications of some bivariate means (including the logarithmic mean, the identric mean, Stolarsky's mean, the harmonic mean, the (weighted) geometric means and their reciprocals, and the Toader--Qi mean) and the multivariate (weighted) geometric means and their reciprocals, derive integral representations of bivariate complex geometric mean and its reciprocal, and apply these newly-derived integral representations to establish integral representations of Heronian mean of power 2 and its reciprocal.

A gold(I) complex with a triphenylphosphine and a monodentate N,N-dimethyldithiocarbamate ligand was synthesized and characterized by Raman spectroscopy and single crystal X-ray diffraction. DFT calculations (Gaussian 09, PBE1PBE/Lanl2dz) were undertaken for a single complex in the gas-phase. The DFT-optimized structure is in good agreement with the crystal structure and the DFT-calculated Raman spectrum also is in excellent agreement with the experimental spectrum. Assignments of the Raman peaks are based on these DFT calculations. Frontier molecular orbitals were calculated and their nature is discussed.

The complex dielectric permittivity, ε (f, H) = εʹ (f, H)- i εʺ (f, H), in the microwave frequency range f, of (0.1 - 3) GHz and polarizing field values H, in the range of (0 - 135) kA/m, was measured for a kerosene-based ferrofluid with magnetite particles. A relaxation process attributed to interfacial type relaxation was highlighted, determining for the first time in the microwave field, the activation energy of the dielectric relaxation process in the presence of the magnetic field, EA(H), in relation to the activation energy in zero field, EA(H=0). Based on the complex permittivity measurements and the Claussius-Mossotti equation, the dependencies on frequency (f), and magnetic field (H), of the polarizability (α) and electrical conductivity (σ), were determined. From the dependence of α(f,H), the electric dipolar moment, p, of the particles in the ferrofluid, was determined. The conductivity spectrum, σ(f,H), was found to be in agreement with Jonscher's universal law and the electrical conduction mechanism in the ferrofluid was explained using both Mott's VRH (variable range hopping) model and CBH (correlated barrier hopping) model. Based on these models and conductivity measurements, the hopping distance, Rh, of the charge carriers and the maximum barrier height, Wm, for the investigated ferrofluid was determined for the first time in the microwave field. Knowledge of these electrical properties of the ferrofluid in the microwave field is useful for explaining the mechanisms of polarization and control of electrical conductivity with an external magnetic field, in order to use ferrofluids in various technological applications in microwave field.

Lotions with or without 28% ascorbyl glucoside arginine complex (AGAC) were applied twice daily for 24 weeks in a double‐blind half‐face study of 27 Japanese females with solar lentigos (SLs). Pigmentation scores were evaluated using a photo‐scale and skin colors were assessed using a color difference meter and a Mexameter. Treatment with the test lotion elicited a significant decrease in pigment scores at 24 weeks compared to week 0; with a significant decrease in pigment scores at 24 weeks compared to the placebo lotion‐treated SLs. In the test lotion‐treated SLs; the L values and melanin index (MI) significantly (p<0.0001) increased and decreased; respectively; at 12 and 24 weeks of treatment compared to week 0. Comparisons of increased L (△L) values or decreased MI (△MI) values between test and placebo lotion‐treated SLs demonstrated that the test lotion‐treated SLs had significantly higher △L or △MI values than the placebo lotion‐treated SLs both at 12 and 24 weeks of treatment. The sum of our results strongly indicates that AGAC is distinctly effective in ameliorating the hyperpigmentation levels of SLs at a visibly recognizable level by the subjects without any hypo‐pigmenting effects or skin irritation.

This study aims to refine our understanding of evolutionary processes, particularly as they apply to complex organisms, using an innovative graph-based simulation approach. We model the topological evolution of simple (5-node ring graph) and complex (20-node dense random graph) organisms over 10 generations, applying different mutation rates to reflect biological realities. Our results provide intriguing insights into the potentially different evolutionary dynamics at play in simple versus complex organisms. While simple organisms demonstrate high topological flexibility and rapid adaptability, aligning with classical evolutionary models, complex organisms exhibit a surprising degree of structural stability. This stability persists even under mutation rates that would typically drive significant changes in simpler systems. The simulation highlights an important consideration: the intricate, interdependent networks characteristic of complex organisms may create a form of evolutionary buffering. This buffering could modulate the impact of random mutations and natural selection – processes that are cornerstones of evolutionary theory. Our findings suggest that the high degree of complexity in advanced life forms may necessitate a more nuanced view of how evolutionary processes operate across different levels of biological organization. Furthermore, the emergence of new structural motifs in simple organisms, contrasted with the relative conservation in complex topologies, indicates that evolutionary mechanisms may manifest differently across the spectrum of biological complexity. This observation invites a more detailed exploration of how evolutionary principles apply to diverse life forms.These results contribute to the ongoing refinement of evolutionary theory, especially in its application to complex organisms. They suggest that additional mechanisms, such as constrained mutations, epigenetic changes, or higher-order organizational principles, may play significant roles alongside random mutations and natural selection in the evolution of complex life forms.

On 17 October 1947, Niels Bohr was made a knight of the Order of the Elephant by the King of Denmark in view of his outstanding achievements and contributions to science. Bohr designed his own coat of arms that featured a pattern of Yin and Yang (Tai Chi symbol) to symbolize the wave-particle complementarity. However, Bohr’s Yin-Yang diagram (YYD) was neither drawn based on the principles of quantum mechanics, nor did it originate from the traditional Taoist YYD. Scientists still have doubts about the legitimacy of using YYD as the icon of the wave-particle complementarity, because the YYD belonging to quantum mechanics itself is unknown so far. This article reports the YYDs existing in quantum mechanics and justifies the role of YYD in the wave-particle duality by showing that any system, whether classical or quantum, has an ideal YYD as long as it satisfies Bohr’s principle of complementarity (BPC). The deviation of a deformed YYD from the ideal YYD indicates the extent to which a real system satisfies BPC. This article constructs the quantum YYD by the complex quantum trajectory of a particle tunneling via a step barrier, which displays the continuous transition between the wave behavior and the particle behavior. It appears that the YYD designed by Bohr in his coat of arms resembles the YYD generated by tunneling motion, not only in appearance but also in the governing equation.

Matrices and their inverses allow accurate calculations to be produced quickly and compactly and can be used to control any process represented by a system of equations. Singular matrices require extensive workarounds (costing time and money) to solve these systems of equations because they have no inverse. Finding their inverse involves division by zero. Nevertheless, recently a new number set called semi-structured complex numbers was developed to enable division by zero in algebraic equations. The aim of this research was to demonstrate that the inverse of a singular matrix can be found using semi-structured complex numbers. This research reveals (1) Singular matrices and their inverses can be used to find a unique solution to a pair of simultaneous equations that appear to have infinitely many solutions or appear to have no solution; (2) Singular matrices map coordinates in projective space to coordinates in Euclidean space and their inverse maps coordinates in Euclidean space to coordinates in projective space; (3) the inverse of a singular matrix proves that parallel lines in Euclidean space do not intersect but in projective space intersect at a “point at infinity” and (4) collinear lines that intersect at infinitely many points in Euclidean space only intersect at one point in projective space.

The pharmaceutical industry usually utilizes either hydrophobic or hydrophilic substances extracted from raw plant materials for preparing a final product, However, the plant material waste still contain substances with an opposite solubility. The aim of this study was to enhance the comprehensive usability of plant materials by developing a new non-wasting extraction method for eucalypt leaves and by investigating the phytochemical and pharmacological properties of eucalypt extracts and their 3D-printed dosage forms. The present extraction method enabled to prepare both hydrophobic soft extracts and hydrophilic (aqueous) dry extracts. We identified total 28 terpenes in the hydrophobic soft extract. In the hydrophilic dry extract, total 57 substances were identified, and 26 of them were successfully isolated. The eucalypt extracts studied showed a significant antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, Candida albicans, Corynebacterium diphtheriae gravis, and Corynebacterium diphtheriae mitis. The anti-inflammatory activity of the dry extract was studied with a formalin oedema model in mice. The maximum anti-exudative effect of the dry extract was 61.5% at a dose of 20 mg/kg. The composite gels of polyethylene oxide and eucalypt extract were developed, and the key process parameters for semi-solid extrusion (SSE) 3D printing of such gels were verified. The SSE 3D-printed preparations of novel synergistically acting eucalypt extracts could have uses in antimicrobial and anti-inflammatory medicinal applications.

A significant number and range of challenges besetting sustainability can be traced to the actions and interactions of multiple autonomous agents (people mostly) and the entities they create (e.g., institutions, policies, social network) in the corresponding social-environmental systems (SES). To address these challenges, we need to understand decisions made and actions taken by agents, the outcomes of their actions, including the feedbacks on the corresponding agents and environment. The science of Agent-based Complex Systems—ACS science—has a significant potential to handle such challenges. The advantages of ACS science for sustainability are addressed by way of identifying the key elements and challenges in sustainability science, the generic features of ACS, and the key advances and challenges in modeling ACS. Artificial intelligence and data science promise to improve understanding of agents’ behaviors, detect SES structures, and formulate SES mechanisms.

This paper utilizes a life cycle assessment to evaluate the energy resources and environmental impacts of three heating systems. In the first step, life cycle assessments (LCAs) are prepared for the renewable, conventional, and combined systems. The system boundary of the LCA method is "cradle to gate," which means it includes the entire life cycle of a product or process. This includes energy supply, transport, energy generation, and operational energy use. The system scenarios were compared based on ecological and energy loads in the second step. Primary energy, resources, emissions, and environmental potentials are calculated for the system scenarios using the life cycle assessment methods CML 2016 and ReCiPe 2016. Finally, models for environmental reliability and complex decision-support tools have been developed. This work addresses two main questions: how to characterize the environmental and energy impacts of the systems under study, and what is the optimal scenario for the system? The research results show that the gas boiler system has a greater environmental impact. The most significant differences between the systems relate to the degrada-tion of abiotic fossil fuels when using a gas boiler and the process of acidification when using an electric heat pump. The results can be used to develop sustainable heating systems with reduced environmental impacts and enhanced energy efficiency.

The efficient recognition and classification of personal protective equipment are essential for en-suring the safety of personnel in complex industrial settings. Using the existing methods, manually performing macro-level classification and identification of personnel in intricate spheres is tedious, time-consuming, and inefficient. The availability of several artificial intelligence models in recent times presents a new paradigm shift in object classification and tracking in complex settings. In this study, several compact and efficient deep learning model architectures are explored, and a new efficient model is constructed by fusing the learning capabilities of the individual, efficient models for better object feature learning and optimal inferencing. The new model construct follows the contributory learning theory whereby each fussed model brings its learned features, which are then combined to obtain a more accurate and rapid model using normalized quantization-aware learning. During the investigation, a separable convolutional driven model was constructed as a base model, and then the various efficient architectures combined for the rapid identification and classification of the various hardhat classes used in complex industrial settings. A remarkable rapid classification and accuracy were recorded with the new resultant model.

This study examined the association between pressure injuries and complexity of abdominal temperature measured in residents of a nursing facility. The temperature served as a proxy measure for skin thermoregulation. Refined multiscale sample entropy and bubble entropy were used to measure the complexity of the temperature time series measured over two days at 1-minute intervals. Robust summary measures were derived for the multiscale entropies and used in predictive models for pressure injuries that were built with adaptive lasso regression and neural networks. Both types of entropies were lower in the group of participants with pressure injuries (n=11) relative to the group of non-injured participants (n=15). This was generally true at the longer temporal scales, with the effect peaking at scale τ=23 minutes. Predictive models for pressure injury on the basis of refined multiscale sample entropy and bubble entropy yielded 92% accuracy, outperforming predictions based on any single measure of entropy. Combining entropy measures with a widely used risk assessment score led to the best prediction accuracy. Complexity of abdominal temperature series could therefore serve as an indicator of risk of pressure injury.

The X-linked FMR1 gene contains a non-coding trinucleotide repeat in its 5’ region that in normal, healthy individuals contains 20-44 copies. Large expansions of this region (>200 copies) cause fragile X syndrome (FXS), but expansions of 55-199 copies (referred to as premutation alleles) predispose carriers to a neurodegenerative disease called fragile X-associated tremor/ataxia syndrome (FXTAS). The cytopathological mechanisms underlying FXTAS are poorly understood, but abnormalities in mitochondrial function are believed to play a role. We previously reported that lymphoblastoid cell lines (LCLs, or lymphoblasts) of premutation carriers have elevated mitochondrial respiratory activities. In the carriers, especially those not clinically affected with FXTAS, AMPK activity was shown to be elevated. In the FXTAS patients, however, it was negatively correlated with brain white matter lesions, suggesting a protective role in the molecular mechanisms. Here we report an enlarged and extended study of mitochondrial function and associated cellular stress-signalling pathways in lymphoblasts isolated from male and female premutation carriers, regardless of their clinical status, and healthy controls. The results confirmed the elevation of AMPK and mitochondrial respiratory activities and reduction of reactive O2 species (ROS) levels in premutation cells and revealed for the first time that TORC1 activities are reduced. Extensive correlation, multiple regression and Principal Components analysis revealed the best fitting statistical explanations of these changes in terms of the other variables measured. These suggested which variables might be the most “proximal” regulators of the others in the extensive network of known causal interactions amongst the measured parameters of mitochondrial function and cellular stress signalling. In the resulting model, the premutation alleles activate AMPK and inhibit both TORC1 and ROS production, the reduced TORC1 activity contributes to activation of AMPK activation and of nonmitochondrial metabolism, and the higher AMPK activity results in elevated catabolic metabolism, mitochondrial respiration and ATP steady state levels. In addition the results suggest a separate CGG repeat number-dependent elevation of TORC1 activity that is insufficient to overcome the inhibition of TORC1 in premutation cells, but may presage the previously reported activation of TORC1 in FXS cells.

System-of-systems (SoS) approach is often used for simulating disruptions to business and infrastructure system networks allowing for integration of several models into one simulation. However, the integration is frequently challenging as each system is designed individually with different characteristics, such as time granularity. Understanding the impact of time granularity on propagation of disruptions between businesses and infrastructure systems and finding the appropriate granularity for the SoS simulation remain as major challenges. To tackle these, we explore how time granularity, recovery time, and disruption size affect the propagation of disruptions between constituent systems of an SoS simulation. To address this issue, we developed a High Level Architecture (HLA) simulation of 3 networks and performed a series of simulation experiments. Our results revealed that time granularity and especially recovery time have huge impact on propagation of disruptions. Consequently, we developed a model for selecting an appropriate time granularity for an SoS simulation based on expected recovery time. Our simulation experiments show that time granularity should be less than 1.13 of expected recovery time. We identified some areas for future research centered around extending the experimental factors space.

The issue of workplace toxicity constitutes a major problem for employers, employees and society at large. Toxicity in a workplace context relates to damaging behaviours perpetrated by individuals and organisations that netatively impact on the health and wellbeing of others. Workplace toxicty is habitually associated with activities such as bullying, harrassment, unethical and even illegal acts. In this article, today’s workplace is likenened to a cage where ambition and greed drive people to engage in toxic behaviour to fight for whatever scarce rewards are on offer. Set against a backdrop of continuous demands on employees in a era of constant change and challenge, leadership practice in the 21st century is understandably seeped in complexity. Whilst conditions of scarcity are in fact constructed by employers in today’s lean environments, workplace toxicity has significant implications for organisational leaders in terms of work place disputes, absenteeism and litigation etc. Twentieth century hierarchial and autocratic leadership models are now deemed to be both obsolete and wholly inadedgate to inform leadership practice in the knowledge era. This conceptual article looks at the efficacy of complexity leadership theory (CLT) in empowering today’s leader to better understand and address 21st century workplace toxicity.

After developed the formulation of a "general relativity" in C⁴ [2], we proceed with the formulation of a Hamilton-Jacobi equation in C⁴. We argue that in this consideration, the usual problems of the ADM formalism, do not exist, due to the complex time as it exists in our consideration. Specically, we can derive a suitable dispersion relation in order to work with and nd a generalised super Hamiltonian

Aiming at the problems of high cost of manual pulling, low reliability of existing pulling devices, high breaking rate and high leakage rate in the process of cotton stalk reuse after leaving the field in Xinjiang cotton area, a loosening soil and root-cutting cotton stalk pulling the setting machine has been researched and designed, established the root-cutting force model, calculated and optimized the key parameters of the V-shaped root-cutting knife, and determined the range of slide cutting angle, cutting edge angle and soil entry angle. The shoveling process simulation of V-shaped root-cutting knife and root-soil complex was constructed, and the working mechanism of V-shaped root-cutting knife was clarified. In order to verify the reliability and operation performance of the V-shaped root-cutting knife, the slide cutting angle, cutting edge angle and soil entry angle were used as the test factors, the response surface test of three-factors and three-levels was carried out with root-breaking force and mean value of the cutting resistance as the test index. The test results were analyzed by variance analysis, the significant of influencing factors on the root-breaking force are in a descending order as: slide cutting angle, cutting edge angle, soil entry angle; the degree of influence on the mean value of the cutting resistance are as follows: slide cutting angle, soil entry angle, cutting edge angle. In order to make the V-shaped root-cutting knife achieve the optimal working state, the parameters of the test index were optimized, and the optimal design parameters of the V-shaped root-cutting knife were set as follows: the slide cutting angle was 48.3°, cutting edge angle was 43.4°, and soil entry angle was 26.2°. The field uprooting test showed that the average pass rate of root breakage was 94.8% and the average pull-out rate of the cotton stalk was 93.2%. This study provides theoretical guidance for the development of root breaking mechanism of cotton straw harvester.

Mastitis-causing bacteria can establish persistent infections in the mammary gland of commercially important dairy animals despite the presence of strong specific humoral and cellular immune mechanisms. The aim of this study was to encapsulate vitamin D3 by complex coacervation with sulfur-saturated bovine lactoferrin-alginate using microbial transglutaminase-catalyzed crosslinking and investigate the oral administration of encapsulated vitamin D3 in blood serum biomarkers of the immune response in late-lactating dairy goats. Dairy goats (n = 18) in late lactation were randomly assigned to three experimental groups (n = 6), after balancing weight. Dairy goats were orally administered with 0.35 mg vitamin D3/day in the unencapsulated form and 0.35 mg vitamin D3/day in the encapsulated powder form. Another group received the basal diet. The experimental period lasted 6 weeks. The blood serum concentrations of 25-hydroxyvitamin D3 [25-(OH)-D3], lactoferrin, immunoglobulin A (IgA), and interferon-gamma (INF-γ) were measured. The delivery of vitamin D3 to dairy goats resulted in a marked increase of 25-(OH)-D3 concentration in serum while the serum level of lactoferrin also increased. Alternatively, the serum levels of IgA and the immunomodulatory cytokine INF-γ were elevated following supplementation with the encapsulated vitamin D3. Overall, the capsules in the powder form used in this study kept vitamin D3 highly bioavailable.

Prolylcarboxypeptidase (PRCP, PCP, Lysosomal Pro-X-carboxypeptidase, Angiotensinase C) controls angiotensin - and kinin- induced cell signaling. Elevation of PRCP appear to be activated in chronic inflammatory diseases (cardiovascular disease (CVD), diabetes) in proportion to severity. Vascular endothelial cell senescence and mitochondrial dysfunction have consistently been shown in models of CVD in aging. The cellular senescence, a driver of age-related dysfunction, can differentially alter the expression of lysosomal enzymes due to lysosomal membrane permeability. There is a lack of data demostrating the effect of age-related dysfunction on the expression and function of PRCP. To explore the changes in PRCP, PRCP-dependent prekallikrein (PK) pathway was charcterized in early – and late-passage human pulmonary artery endothelial cells (HPAECs). Detailed kinetic analysis of cells treated with high molecular weight kininogen (HK), a precursor of bradykinin (BK), and PK revealed a mechansim by which senescent HPAECs activate the generation of kallikrein upon the assembly of the HK-PK complex on HPAECs in parallel with an upregulation of PRCP and endothelial nitric oxide (NO) synthase (eNOS) and NO formation. The NO production and expression of both PRCP and eNOS increased in early-passage HPAECs while decreased in late-passage HPAECs. Low activity of PRCP in late passage HPAECs was associated with rapid decreased telomerase reverse transcriptase mRNA levels. We also found that, with an increase in the passage number of HPAECs, reduced PRCP altered respiration rate. These results indicated that aging dysregulates PRCP protein expression, and further studies will shed light into the complexity of PRCP-dependent signling pathway in aging.

As a key mediator of chronic pain, neurotrophin nerve growth factor (NGF) binds to two neurotrophin receptors: p75 neurotrophin receptor (p75NTR) and tyrosine kinase receptor A (TrkA). The formation of the p75NTR-NGF-TrkA complex is implicated in the potentiation of chronic pain signals, making it an attractive target for therapeutic explorations. NGF analogues and monoclonal antibodies (mAbs) targeting NGF represent two distinct approaches in modulating the intricate signaling pathways involved in pain transduction mediated by the p75NTR-NGF-TrkA complex. While NGF analogues offer the advantage of tailored design to fine-tune neurotrophic responses, monoclonal antibodies provide a more systemic and comprehensive blockade of NGF, inhibiting its interactions with both p75NTR and TrkA receptors. However, the use of mAbs may pose challenges related to potential side effects and interference with the physiological functions of NGF. As a result, balancing the benefits and drawbacks of the two approaches is critical for advancing therapeutic strategies towards the alleviation of p75NTR-NGF-TrkA-mediated pain. In this study, therefore, a novel structural and biophysical approach was employed for the design of NGF analogues to suppress p75NTR-NGF-TrkA-related chronic pain signaling. Employing high-throughput structural modeling and biophysics-based intermolecular binding affinity calculations, this article for the first time puts forward a set of NGF analogues, including in particular NGF analogues with four site-specific mutations, for whose dimerizations the K d at 37 ^◦C were reduced by three orders of magnitude (from 10^-9 M to 10^-6 M) compared to the K d at 37 ^◦C for the dimerization of native NGFs. Overall, the integration of structural and biophysical perspectives enhances our understanding of the rational design of NGF analogues as promising candidates for the development of NGF-targeted analgesic therapies, which balances the benefits and drawbacks of anti-NGF antibodies and NGF analogues for advancing therapeutic strategies towards the alleviation of p75NTR-NGF-TrkA-mediated pain.

Novel drugs profoundly changed the outcomes in CLL patients and traditional prognostic/predictive factors that were delineated in the era of chemo-immunotherapy need to be validated in the contest of these new targeted therapies. Currently, the most important prognostic genetic biomarkers are immunoglobulin heavy chain variable (IGHV) mutational status, genetic aberrations including del(17p)/TP53 abnormalities and the complex karyotype. In this review we discuss the prognostic/predictive role of these genetic markers in relation to novel treatments. Moreover, we present and discuss the new score systems that were elaborated and validated in the era of new drugs. Given the deeper responses obtained with small molecules, new prognostic/predictive markers, including measurable residual disease, and validated prognostic scores could possibly be incorporated into routine prognostic scores, to better identify “very-high” CLL patients, who will need more effective treatments.

In this paper, we investigate the structural, microstructural, dielectric, and energy storage properties of Nd and Mn co-doped Ba0.7Sr0.3TiO3 [(Ba0.7Sr0.3)1-xNdxTi1-yMnyO3 (BSNTM) ceramics (x = 0, 0.005, and y = 0, 0.0025, 0.005, and 0.01)] via a defect dipole engineering method. The complex defect dipoles (MnTi"-VO∙∙)∙ and (MnTi"-VO∙∙) between acceptor ions and oxygen vacancies capture electrons, enhancing the breakdown electric field and energy storage performances. XRD, Raman spectroscopy, and microscopic investigations of BSNTM ceramics revealed the formation of a tetragonal phase, increased oxygen vacancies, and reduced grain size with Mn dopant, respectively. The BSNTM ceramics with x=0.005 and y=0 exhibit a high dielectric constant of 2058 and a dielectric loss of 0.026 at 1 kHz. These values gradually decreased to 1876 and 0.019 for x=0.005 and y=0.01 due to the Mn2+ ions at Ti4+-site, which facilitates the formation of oxygen vacancies, and prevents the decrease of Ti4+. In addition, the defect dipoles act as a driving force for depolarization to tailor the domain formation energy and domain wall energy, which provides a high difference between the maximum polarization of Pmax and remnant polarization of Pr (ΔP=10.39 µC/cm2). Moreover, the complex defect dipoles with optimum oxygen vacancies in BSNTM ceramics can provide not only a high ΔP but also reduce grain size, which together improve the breakdown strength from 60.4 to 110.6 kV/cm, giving rise to a high energy storage density of 0.41 J/cm3 and high efficiency of 84.6% for x=0.005 and y=0.01. These findings demonstrate that defect dipoles engineering is an effective method to enhance the energy storage performance of dielectrics for capacitor applications.

Since 2020 COVID-19 has caused serious mortality around the world. Given the ambiguity in es-tablishing COVID-19 as the direct cause of death we first investigate the effects of age and sex upon all-cause mortality during 2020 and 2021 in England and Wales. Since infectious agents have their own unique age profile for death, we explore several methods to adjust single year of age deaths in England and Wales during 2019 (the pre-COVID-19 base year) to a pathogen-neutral single year of age baseline. This adjusted base year is then used to confirm the widely reported higher deaths in males for most ages above 43 years in both 2020 and 2021. During 2020 (+ COVID-19 but no vac-cination) both male and female population-adjusted deaths were significantly increased above age 35. A significant reduction in all-cause mortality among both males and females aged 75+ could be demonstrated in 2021 during widespread COVID–19 vaccination, however, below age 75 deaths progressively increased. This finding arises from a mix of vaccination and year of age profiles of deaths for the different SARS-CoV-2 variants. In addition, specific effects for age around puberty were demonstrated where females had higher deaths rather than males. There is evidence that year-of-birth cohorts may also be involved, indicating that immune priming to specific pathogen outbreaks in the past may lead to lower deaths for some birth cohorts. To specifically identify the age profile for the COVID-19 variants in 2020 to 2023, we employ the proportion of total deaths at each age which are potentially due to or ‘with’ COVID-19. The original Wuhan strain, and the Alpha variant show somewhat limited divergence in the age profile with the Alpha variant shifted to a moderately higher proportion of deaths below age 84. The Delta variant specifically targeted persons below age 65. The Omicron variants showed significantly lower proportion of overall mortality, with markedly higher relative proportion of deaths above age 65 steeply increasing with age to a maximum around 100 years of age. A similar age profile for the variants can be seen in the age-banded deaths in US states – although slightly obscured by using age bands rather than single year of age. However, the US data shows that higher male deaths are greatly dependent on age and the COVID-variant. Deaths determined as ‘due to’ COVID-19 (as opposed to ‘involving’ COVID-19) in England and Wales were especially over-estimated in 2021 relative to the change in all-cause mortality. This arose as a by-product of an increase in COVID-19 testing capacity in late 2020. Potential structure-function mechanisms for the year of age specificity of SARS-CoV-2 var-iants are discussed. The question is posed as to whether vaccines based on different variants carry the specific age profile through into the vaccine.

All vaccines exhibit both specific and non-specific effects. The specific effects are measured by the efficacy against the target pathogen, while the non-specific effects can be detected by the change in all-cause mortality . All-cause mortality data (gender, age band, vaccination history, month of death) between January 2021 and May 2022 was compiled by the Office for National Statistics. COVID–19 vaccination gave good protection on many occasions but less so for younger ages. Each gender and age group shows its own unique vaccination benefit/disbenefit time profile. Individuals are free to make vaccination decisions. For example, women aged 18-39 show a cohort who do not progress beyond the first or second dose. The all-cause mortality outcomes for the Omicron variant showed a very poor response to vaccination with 70% of sex/age/vaccination stage/month combinations increasing all-cause mortality, probably due to unfavorable antigenic distance between the first-generation vaccines and this variant, and additional non-specific effects. The all-cause mortality outcomes of COVID–19 vaccination is far more nuanced than have been widely appreciated, and virus vector appear better than the mRNA vaccines in this specific respect. The latter are seemingly more likely to increase all-cause mortality especially in younger age groups. An extensive discussion/literature review is included to provide potential explanations for the observed unexpected vaccine effects.

The present era of the Internet of Things (IoT) having intelligent functionalities in solving problems pertaining to realtime mission-critical systems has brought an immense revolution in diverse fields including healthcare and navigation systems. However, to the best of our knowledge, the potential of IoT has not been fully exploited yet in the field of the energy sector. We argue that there is an immense need to shift the traditional mission-critical electric power system architecture to IoT-based fully orchestrated architecture in order to increase efficiency, as billions of investment is reserved for the energy sector globally. Since network orchestration deals with auomating the interaction between multiple components involved to execute a particular service, therefore, scheduling the relevant processes within strict deadlines becomes the core pillar of the architecture. The mission-critical systems with urgent task execution often suffer from issues of missing task deadlines. In this study, we present a novel IoT task orchestration architecture for efficient energy management of a nanogrid system that focuses on minimizing the use of nonrenewable energy resources and maximizing the use of renewable energy resources. Moreover, major components of IoT task orchestration such as task mapping and task scheduling are also enhanced using NLP and PSO optimization modules. The proposed task scheduling algorithm incorporates the optimized surplus time, and efficiently executes the energy management-related tasks contemplating to their types. The study utilizes sensors to obtain data from physical IoT devices, including photovoltaic (PV), Energy Storage System (ESS), and diesel generator (DG). The performance of the proposed model is evaluated using data set of nanogrid houses. The outcomes revealed that IoT-task orchestration has played a pivotal role in efficient energy management for nanogrid mission-critical system. Furthermore, the comparison with state-of-the-art scheduling algorithms showed that the task starvation rate is reduced to 16% and 12% when compared with RR and FEF algorithms, respectively.

Apple replant disease is a severe problem in orchards and tree nurseries. Evidence for the involvement of a nematode-microbe disease complex was reported. To search for this complex, plots with a history of apple replanting, and control plots cultivated for the first time with apple were sampled in two fields in two years. Shoot weight drastically decreased with each replanting. Nematodes were extracted from soil samples by floatation-centrifugation, washed on a 20 µm-sieve, and used for DNA extraction. Nematode communities and co-extracted fungi and bacteria were analyzed by high-throughput sequencing of amplified ribosomal fragments. The nematode community and co-extracted fungal and bacterial communities significantly differed between replanted and control plots. Free-living nematodes of the genera Aphelenchus, Cephalenchus, and an unidentified Dorylaimida were associated with replanted plots, as indicated by linear discriminant analysis effect size. Among the co-extracted fungi and bacteria, Mortierella was most indicative of replanting. Some genera, mostly Rhabditis, indicated healthy control plots. Isolating and investigating the putative disease complexes will help to understand and alleviate stress-induced root damage of apple in replanted soil.

A multiscale mathematical model is proposed seeking to study the propagation dynamics of the Human Immunodeficiency Virus (HIV) in a group of young people between 15 and 24 years of age, through sexual contact without protection, considering the use of antiretroviral therapy (ART) and therapeutic failure. The model consists in a scale-free complex network that follows a power law, coupled with the immunological dynamics of each individual, that is, it considers the infection by the virus in the immune system of each HIV carrier, through a system of non-linear differential equations that govern the infection’s behavior in the immune system. Propagation of the virus in the network is modelled by taking into account information from the immunological status of each person. The study found that for a population to have high HIV prevalence, it is not necessary at the beginning of the simulation time for the virus to propagate rapidly. In addition, the study proves that with a higher number of sexual partners, there will be greater prevalence of HIV in the population and that the use of ART helps to control the propagation of the infection in the population. As an interesting result, it was also found that there is a higher number of HIV carriers who abandon ART than those who have access to it.

As a candidate for bifunctional asymmetric catalysts containing a half-sandwich C–N chelating Ir(III) framework (azairidacycle), a dinuclear Ir complex with an axially chiral linkage is newly designed. An expedient synthesis of chiral 2,2’-bis(aminomethyl)-1,1’-binaphthyl (1) from 1,1-bi-2-naphthol (BINOL) was accomplished by a three-step process involving nickel-catalyzed cyanation and subsequent reduction with Raney-Ni and KBH4. The reaction of (S)-1 with an equimolar amount of [IrCl2Cp*]2 (Cp* = 5-C5(CH3)5) in the presence of sodium acetate in acetonitrile at 80 °C gave a diastereomeric mixture of new dinuclear dichloridodiiridium (5) through the double C–H bond cleavage, as confirmed by 1H NMR spectroscopy. A loss of the central chirality on the Ir centers of 5 was demonstrated by treatment with KOC(CH3)3 to generate the corresponding 16e amidoiridium complex 6. The following hydrogen transfer from 2-propanol to 6 provided diastereomers of hydrido(amine)iridium with retaining the bis(azairidacycle) architecture. The dinuclear chlorido(amine)iridium 5 can serve as a catalyst precursor for the asymmetric transfer hydrogenation of acetophenone with a substrate to catalyst ratio of 200 in the presence of KOC(CH3)3 in 2-propanol, leading to (S)-1-phenylethanol with up to 67% ee.

Distributed Systems architectures are becoming the standard computational model for processing and transportation of information, especially for Cloud Computing environments. The increase in demand for application processing and data management from enterprise and end-user workloads continues to move from a single-node client-server architecture to a distributed multitier design where data processing and transmission are segregated. Software development must considerer the orchestration required to provision its core components in order to deploy the services efficiently in many independent, loosely coupled - physically and virtually interconnected - data centers spread geographically, across the globe. This network routing challenge can be modeled as a variation of the Travelling Salesman Problem (TSP). This paper proposes a new optimization algorithm for optimum route selection using Algorithmic Information Theory. The Kelly criterion for a Shannon-Bernoulli process is used to generate a reliable quantitative algorithm to find a near optimal solution tour. The algorithm is then verified by comparing the results with heuristic solutions in 3 test cases. A statistical analysis is designed to measure the significance of the results between the algorithms and the entropy function can be derived from the distribution. The tested results shown an improvement in the solution quality by producing routes with smaller length and time requirements. The quality of the results proves the flexibility of the proposed algorithm for problems with different complexities without relying in nature-inspired models such as Genetic Algorithms and Simulated Annealing. This algorithm can be used by orchestration applications to deploy services across large cluster of nodes by making better decision in the route design.

Reservoir computers (RCs) are a biology inspired computational framework for signal processing typically implemented using recurrent neural networks. Recent work has shown that Boolean networks (BN) can also be used as reservoirs. We analyze the performance of BN RCs, measuring their flexibility and identifying factors that determine effective approximation of Boolean functions that are applied in a sliding-window fashion over a binary signal, either non-recursively or recursively. We train and test BN RCs of different sizes, signal connectivity, and in-degree to approximate 3-bit, 5-bit and 3-bit recursive binary functions. We analyze how BN RC parameters and function average sensitivity, a measure of function smoothness, affect approximation accuracy as well as the spread of accuracies for a single reservoir. We found that approximation accuracy and reservoir flexibility are highly dependent on RC parameters. Overall, our results indicate that not all reservoirs are equally flexible and RC instantiation and training can be more efficient if this is taken into account. The optimum range of RC parameters opens up an angle of exploration for understanding how biological systems might be tuned to balance system restraints with processing capacity.

Decision sciences (DSC) involve studying complex dynamic systems and processes to aid informed choices subject to constraints in uncertain conditions. It integrates multidisciplinary methods, techniques, and strategies to evaluate decision engineering processes, identifying alternatives and providing insights towards enhancing prudent decision-making. This study analyzes the evolutionary trends and innovation in DSC education and research to uncover the transformations over the years. We employ the science mapping method, text analytics, and metadata from bibliographic databases to evaluate thematic and social structures. The results highlight data science methods, including data mining and business/learning analytics as essential components. The evolutionary trends in DSC education and research mirror the development in practice, including technological transformation, computer science advances, and engineering processes. Sustainable education through virtual/online learning also constitutes a significant component of scientific production. The evolutionary trends in DSC education and research highlight innovative pedagogical approaches and strategies, including computer simulation and games ('play and learn'). The current era witnessed generative artificial intelligence (GenAI) adoption (e.g., ChatGPT) in teaching, learning, and scholarly activities amidst challenges (academic integrity, plagiarism, intellectual property violations, and other ethical and legal issues). Future research will implement and integrate AI automatic detection systems to address some GenAI adoption challenges.