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Preprint REVIEW | doi:10.20944/preprints202306.2170.v1

What Nutraceuticals Can Do for Duchenne Muscular Dystrophy: Lessons Learned from Amino Acid Supplementation in the Mouse Model

Boel De Paepe

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: N-acetylcysteine; amino acid supplements; L-arginine; Duchenne muscular dystrophy; mdx mouse; osmolytes; supportive therapy; taurine

Online: 30 June 2023 (07:13:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0064.v2

Reconstructing the Global Stress of Marine Structures Based on Artificial Intelligence

Tao Zhang, Jiajun Hu, Erkan Oterkus, Selda Oterkus, Xueliang Wang, Zhentao Jiang, Qua Zhu, Guocai Chen

Subject: Engineering, Marine Engineering Keywords: n/a; ship and Ocean Engineering; Marine Structures; Global Stress; Artificial Intelligence; structure health monitoring (SHM)

Online: 8 June 2023 (10:52:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1574.v1

Personalized Medicine of Omega-3 Fatty Acids in Depression Treatment in Obese and Metabolically Dysregulated Patients

Suet-Kei Wu, Wei-Jen Chen, Jane Pei-Chen Chang, Ta-Wei Guu, Ming-Che Hsin, Chih-Kun Huang, David Mischoulon, Lucile Capuron, Kuan-Pin Su

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: omega-3 polyunsaturated fatty acids (n-3 PUFAs); major depressive disorder (MDD); obesity; metabolic dysregulation; comorbidities

Online: 23 May 2023 (04:54:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1312.v1

Electrochemical Multiplexed N-terminal Natriuretic Peptide and Cortisol Detection in Human Artificial Saliva: Heart Failure Biomedical Application

El Kahina Ghedir, Abdoullatif Baraket, Messaoud Benounis, Nadia Zine, Abdelhamid ERRACHID

Subject: Chemistry And Materials Science, Electrochemistry Keywords: Multiplexed detection; N-terminal Brain Natriuretic Peptide; Cortisol; human saliva analysis; electrochemical impedance spectroscopy; heart failure.

Online: 18 May 2023 (09:32:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0110.v1

Inhibition of Enzymatic Acetylation-Mediated Resistance to Plazomicin by Silver Ions

David Ngo, Angel Magaña, Tung Tran, Jan Sklenicka, Kimberly Phan, Brian Eykholt, Verónica Jimenez, María S. Ramirez, Marcelo E. Tolmasky

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: AAC(2′)-Ia; aminoglycoside 2′-N-acetyltransferase type Ia; aminoglycoside; multidrug resistance; metal ions; plazomicin; adjuvant

Online: 6 January 2023 (02:26:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0063.v1

Potent Antiplasmodial Derivatives of the Antitussive Drug Dextromethorphan Reveal the Ent-Morphinan Pharmacophore of Tazopsine-Type Alkaloids

Antoinette Keita, Jean-François Franetich, Maelle Carraz, Loise Valentin, Mallaury Bordesoulles, Ludivine Baron, Pierre Bigeard, Florian Dupuy, Valentine Geay, Maurel Tefit, Véronique Sarrasin, Sylvie Michel, Catherine Lavazec, Sandrine Houzé, Dominique Mazier, Valérie Soulard, François-Hugues Porée, Romain Duval

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Malaria, Plasmodium berghei, Plasmodium falciparum, hepatic stages, blood stages, prophylaxis, tazopsine, dextromethorphan, N-alkylation, hit compounds.

Online: 6 January 2022 (10:11:44 CET)

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Working Paper ARTICLE

Theoretical Calculation of Wind (Or Water) Turbine: Extending the Betz Limit

Pierre Lecanu, joel Breard, Dominique Mouaze, Bertil Smorgrav

Subject: Physical Sciences, Applied Physics Keywords: n/a; wind turbine; tidal turbine; betz limit; Betz's law; HAWT; VAWT; potential energy; kinetic energy

Online: 27 August 2021 (11:15:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0588.v1

Biophysical, Biochemical and Biomedical Evaluation of Collagen Hydrolysate in Comparison to Sulfated Glucosamine from Marine Organisms and Lipids of Fish Oil Origin Used as Chondroprotective Food Supplements

Thomas Eckert, Mahena Jährling-Butkus, Helen Louton, Monika Burg-Roderfeld, Ning Zhang, Ruiyan Zhang, Karsten Hesse, Athanasios K. Petridis, Tibor Kožár, Jürgen Steinmeyer, Roland Schauer, Peter Engelhard, Anna Kozarova, John W. Hudson, Hans-Christian Siebert

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: osteoarthritis; collagen-hydrolysate; sulfated N-acetyl glucosamine; sialic acids; eicosapentaenoic acid (EPA); MMP-3; ADAMTS-5

Online: 25 May 2021 (08:27:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0079.v1

CdTe X/γ-ray Detectors With Different Contact Materials

Volodymyr Gnatyuk, Olena Maslyanchuk, Mykhailo Solovan, Viktor Brus, Toru Aoki

Subject: Physical Sciences, Acoustics Keywords: CdTe detectors; X-ray and gamma ray spectroscopy; Schottky contact; p-n junction; charge transport mechanism

Online: 2 April 2021 (18:15:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0417.v2

Comparing Biochar-Swine Manure Mixture to Conventional Manure Impact on Soil Nutrient Availability and Plant Uptake – A Greenhouse Study

Chumki Banik, Jacek Koziel, Darcy Bonds, Asheesh Singh, Mark Licht

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: nutrient use efficiency; plant uptake; N-mineralization; carbon sequestration; manure management; animal-crop production systems; sustainability

Online: 3 March 2021 (09:49:16 CET)

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The use of swine manure as a source of plant nutrients is one alternative to synthetic fertilizers. However, conventional manure application with >90% water and a low C:N ratio results in soil C loss to the atmosphere. Our hypothesis was to use biochar as a manure nutrient stabilizer that would slowly release nutrients to plants upon biochar-swine manure mixture application to soil. The objectives were to evaluate the impact of biochar-treated swine manure on soil total C, N, and plant-available macro and micronutrients in greenhouse-cultivated corn (Zea mays L.) and soybean (Glycine max (L.) Merr.). Neutral pH red oak (RO), highly alkaline autothermal corn stover (HAP), and mild acidic Fe-treated autothermal corn stover (HAPE) biomass were pyrolyzed to prepare biochars. Each biochar was surface-applied to swine manure at a 1:4 (biochar wt/manure wt) ratio to generate mixtures of manure and respective biochars (MRO, MHAP, and MHAPE). Conventional manure (M) control and manure-biochar mixtures were then applied to the soil at a recommended rate. Corn and soybean were grown under these controls and treatments (S, M, MRO, MHAP, and MHAPE) to evaluate the manure-biochar impact on soil quality, plant biomass yield, and nutrient uptake. Soil OM significantly (<0.05) increased in all manure-biochar treatments; however, no change in soil pH or N was observed under any treatment. No difference in soil ammonium between treatments was identified. There was a significant decrease in soil M3-P and soil NO₃^- for all manure-biochar treatments compared to the conventional M. However, the plant biomass nutrient concentrations were not significantly different from control manure. Moreover, an increasing trend of N and decreasing trend of P in the plant under all biochar-manure treatments than the controls were noted. This observation suggests that the presence of biochar is capable of influencing the soil N and P in such a way as not to lose those nutrients at the early growth stages of the plant. In general, no statistical difference in corn or soybean biomass yield and plant nutrient uptake for N, P, and K was observed. Interestingly, manure-biochar application to soil significantly diluted the M3-extractable soil Cu and Zn concentrations. The results attribute that manure-biochar has the potential to be a better soil amendment than conventional manure application to the soil.

Preprint ARTICLE | doi:10.20944/preprints202008.0624.v1

Root Traits and Architecture Affect Standard Litter Decomposition: A Comparative Study on Five Plant Species

Adriano Sofo, Hazem S. Elshafie, Ippolito Camele

Subject: Biology And Life Sciences, Plant Sciences Keywords: litter decomposition; root development and morphology; root-soil continuum; soil C/N; tea bags; telluric microorganisms

Online: 28 August 2020 (08:14:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0381.v2

Identification of 22 N-glycosites on Spike Glycoprotein of SARS-CoV-2 and Accessible Surface Glycopeptide Motifs: Implications on Vaccination and Antibody Therapeutics

Dapeng Zhou, Ruibing Qi, Wen Zhang, Xiaoxu Tian, Chao Peng

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: SARS-CoV2; corona virus; glycopeptide; N-linked glycans; mass spectrometry; antibody; cryo-EM structure; crystal structures; epitope prediction

Online: 13 April 2020 (11:09:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0215.v1

N-Heterocyclic Carbene-Platinum Complexes Featuring an Anthracenyl Moiety: Anti-Cancer Activity and DNA Interaction.

Sébastien Harlepp, Edith Chardon, Mathilde Bouché, Georges Dahm, Mounir Maaloum, Stéphane Bellemin-Laponnaz

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Platinum, N-heterocyclic carbene ligand, anticancer activity, DNA interaction, optical tweezers technique, liquid phase AFM microscop

Online: 18 July 2019 (10:17:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0003.v1

The Docking Studies of New Derivatives of N-Phenylanthranilic Acids as Inhibitors of Microsomal Prostaglandin E Synthase-1 (mPGES-1)

Marharyta M. Suleiman, Diana A. Alferova, Valentina V. Druhovina, Olena M. Sergienko, Natalya P. Kobzar, Olga V. Kiz

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: derivatives of N-phenylanthranilic acids; anti-inflammatory activity; flexible molecular docking; microsomal prostaglandin E synthase-1

Online: 1 March 2018 (04:58:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints201712.0016.v1

Hypo-q-Norms on Cartesian Products of Algebras of Bounded Linear Operators on Hilbert Spaces

Silvestru Sever Dragomir

Subject: Computer Science And Mathematics, Mathematics Keywords: Hilbert spaces; bounded linear operators; operator norm and numerical radius; n-tuple of operators; operator inequalities

Online: 4 December 2017 (05:43:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.2063.v1

Multi-Echo Complex Quantitative Susceptibility Mapping and Quantitative Blood Oxygen Level Dependent Magnitude (mcQSM+qBOLD or mcQQ) for Oxygen Extraction Fraction (OEF) Mapping

Junghun Cho, Jinwei Zhang, Pascal Spincemaille, Hang Zhang, Thanh D. Nguyen, Shun Zhang, Ajay Gupta, Yi Wang

Subject: Engineering, Bioengineering Keywords: oxygen extraction faction; quantitative susceptibility mapping; quantitative blood oxygen level-dependent imaging; multi-echo complex quantitative susceptibility mapping and quantitative blood oxygen level dependent magnitude; QSM+qBOLD; QQ; mcQQ; deep learning; magnetic resonance imaging; MRI

Online: 27 December 2023 (09:10:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.2065.v1

Individual, Household, and Community-Level Determinants of Co-Existing Anemia and Undernutrition among Pregnant Women in the Northern Zone of the Sidama Region, Ethiopia: A Multi-Level Analysis

Amanuel Yoseph, Lakew Mussie, Mehretu Belayneh

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: co-existing anemia and undernutrition; prevalence; determinants; modified Poisson regression; multi-level analysis; Sidama region; Ethiopia

Online: 29 August 2024 (11:57:21 CEST)

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Introduction: Anemia and undernutrition are severe public health concerns in Ethiopia. These are the two most common nutritional disorders in pregnant women and frequently co-exist. However, to the best of our knowledge, the evidence is lacking on the co-existence of anemia and undernutrition among pregnant women. Therefore, this study aimed to examine the prevalence of co-existing anemia and undernutrition (CAU) and associated factors among pregnant women. Methods: A community-based cross-sectional study was conducted from June 1–25, 2024, on a sample of 515 pregnant women in the Hawela Lida district of Sidama region, Ethiopia. We utilized a multi-stage sampling method to choose eligible study participants. A pre-tested and structured questionnaire was used to collect data via the online Open Data Kit mobile tool. We controlled the effect of confounders and clustering by using a multi-level mixed-effect modified Poisson regression analysis model. Result: The prevalence of CAU among pregnant women was 25.4% (95% CI: 21.9–28.9). The prevalence of CAU was associated with household food insecurity (adjusted prevalence ratio [APR]: 2.17; 95% CI: 1.43–3.28), training on model family (APR: 0.66; 95% CI: 0.45-0.96), inadequate dietary diversity (APR: 1.51; 95% CI: 1.18–1.95), and having poor knowledge of nutrition (APR: 1.55; 95% CI: 1.06-2.26) at individual levels. Low community-level women’s autonomy (APR: 6.19; 95% CI: 3.42-11.22) and community-level road accessibility (APR: 0.65; 95% CI: 0.43-0.98) were the identified determinants of CAU at the community level. Conclusion: One in four pregnant women was CAU in the study area. Household food insecurity, receiving model family training, inadequate dietary diversity, having poor knowledge of nutrition, low community-level women’s autonomy, and community-level road accessibility were the significant determinants of CAU. Therefore, inter-sectorial collaboration should be required to comprehensively address the determinants of CAU at different levels. Besides, any CAU prevention and intervention programs should provide model family training specifically targeting women who have poor nutritional knowledge and a low level of autonomy in health care decision-making.

Preprint ARTICLE | doi:10.20944/preprints202403.1578.v1

Structural Analysis in the Sympathetic Restoration and Conservation of the Gopinath Temple, Kathmandu, Nepal

Andrés Arce, Alejandro Jiménez Rios, Igor Tomic, David Biggs

Subject: Engineering, Architecture, Building And Construction Keywords: Nepal heritage conservation; Gorka earthquake; Gopinath temple; structural analysis; safety level assessment; sympathetic intervention proposal; sustainability

Online: 26 March 2024 (10:08:39 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.1729.v1

Climate Change: Causes, Impacts, and Strategies for a Sustainable Future

Md Redowan Rashid

Subject: Environmental And Earth Sciences, Sustainable Science And Technology Keywords: Global Warming; Greenhouse Gases; Sea-Level Rise; Deforestation; Fossil Fuels; Renewable Energy; Climate Resilience; Sustainable Practices

Online: 22 December 2023 (14:38:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0538.v1

Impact of [18F]PSMA-1007 PET/CT Comparative to [18F]FLUOROCHOLINE PET/CT on Treatment Decision for Prostate Cancer Patient on Biological Recurrence: A Multicentric Prospective Observational Study

Agathe FEVRIER, Clément Bouron, Manon De Vries, Ouassim Medhioub, Franck Lacoeuille, Pierre-Jean Mention

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: [18F]PSMA-1007 PET/CT; [18F]F-Choline PET/CT; prostate; therapeutic management; PSA level; SUVmax

Online: 8 November 2023 (10:30:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1808.v1

Accounting for the Evolution of Sedentarism in Food Security Assessment

Jacob Michels, John C. Beghin

Subject: Business, Economics And Management, Economics Keywords: sedentary behavior; leisure; food security; physical activity level (PAL); minimum dietary energy requirement (MDER); transfer function

Online: 27 October 2023 (13:19:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0792.v1

Spatial Analysis of Coastal Changes and Its Implications for Understanding Prehistoric Human Settlement Patterns in the Southwestern Iberian Peninsula

Mejías-García Juan Carlos, Fraile-Jurado Pablo

Subject: Arts And Humanities, Archaeology Keywords: Sea level change; Paleo-coastline; Prehistory; Southwestern Iberian Peninsula; Marine resources exploitation; Spatial Database; Geostatistical analysis

Online: 12 October 2023 (14:23:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1662.v1

Fiscal Expenditure on People's Livelihood and the Achievement of Regional High-Quality Economic Development Systems: Evidence from China

Guowei Wang, Liang Zhang, Dingqing Wang

Subject: Business, Economics And Management, Economics Keywords: Economic high-quality development systems; Fiscal expenditure on people's livelihood; Consumption level; Urbanization; Well-being economy

Online: 23 June 2023 (11:11:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0161.v1

Translating GPDRR UNDRR 2022, Sendai Framework, and the Bali Agenda for Resilience into Action: Mangrove-Nature Based Solutions and Local Wisdom in Mitigating Sea Level Rise Flood Disasters In Indonesia

Andri Wibowo

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Bedono Village; GPDRR UNDRR 2022; the Bali Agenda for Resilience; the Sendai Framework; sea level rise

Online: 10 June 2022 (11:04:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0006.v1

Coastal Flooding & Sea-Level Rise: Calculation of Flood Risk Using Tide-Gauge Measurements

Stephen Taylor

Subject: Environmental And Earth Sciences, Oceanography Keywords: Sea Level Rise; coastal flooding; JPM; Gumbel; exceedance; extreme value statistics; flood return period; sea-defences

Online: 1 June 2022 (05:58:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0086.v1

Evaluation of the Applicability of the ERA5 Reanalysis for Interpretation of the Polarization Laser Sensing Data of the High-Level Clouds in Western Siberia

Ilya Bryukhanov, Maxim Penzin, Olesia Kuchinskaia, Evgeny Ni, Konstantin Pustovalov, Valentina Bryukhanova, Nikolay Kirillov, Ivan Zhivotenyuk, Anton Doroshkevich, Alexander Stykon, Iurii Bordulev, Vadim Kostyukhin, Ignatiy Samokhvalov

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: atmosphere; high-level clouds; ice particles; polarization lidar; interpretation of lidar data; radiosonde observations; ERA5 reanalysis.

Online: 7 May 2022 (03:12:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202202.0221.v1

Diet, Oxidative Stress, and Blood Serum Nutrients in Various Types of Glaucoma: A Systematic Review

Maryla Młynarczyk, Martyna Falkowska, Zuzanna Micun, Iwona Obuchowska, Jan Kochanowicz, Katarzyna Socha, Joanna Konopińska

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: primary open angle glaucoma; primary angle-closure glaucoma; PEX glaucoma; diet; oxidative stress; nutrients serum level

Online: 18 February 2022 (03:38:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0159.v1

Time Granularity Impact on Propagation of Disruptions in a System-of-Systems Simulation of Infrastructure and Business Networks

Mateusz Iwo Dubaniowski, Hans Rudolf Heinimann

Subject: Engineering, Automotive Engineering Keywords: system-of-systems; High Level Architecture (HLA); infrastructure modelling; infrastructure resilience; time granularity; complex networks; synchronization.

Online: 4 March 2021 (13:01:47 CET)

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Working Paper ARTICLE

How and to Which Extent Can the Gas Sector Contribute to a Climate-Neutral European Energy System? A Qualitative Approach

Christian Lebelhuber, Horst Steinmüller

Subject: Engineering, Energy And Fuel Technology Keywords: energy system; energy policy; climate neutrality; renewable gas; biomethane; power-to-gas; technical potential; support level

Online: 19 March 2019 (10:30:53 CET)

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Background: Mitigating climate change requires fundamentally redesigned energy systems in which renewable energy sources ultimately replace fossil fuels such as natural gas. In this context, the question how and to which extent the gas sector can contribute to an increasingly climate-neutral future EU energy system is heavily debated among scholars, energy industry experts and policy makers. Methods: We take a two-step approach: We begin with a review of studies from energy industry and academia to discuss potential gas sector contributions from a holistic energy system design point of view; this is followed by a comprehensive discussion of technical potentials, micro-economic conditions and societal implications of renewable gas. We then enrich our findings with the results of an empirical focus group process. Results: The gas sector can not only contribute to balancing volatile renewable energy production but also enable the supply of renewable energy to end-users in gaseous form; based on existing infrastructure. This could reduce costs for society, increase public acceptance and ultimately speed up the energy system transformation. There is the theoretical technical potential to substitute major parts of natural gas with renewable gas of biogenic and synthetic nature. This, however, crucially requires a supportive policy framework like the one established for renewable electricity. Conclusion: Given the societal benefits and the competitiveness of renewable gas as compared to renewable alternatives, energy policy makers should incorporate renewable gas and the existing gas infrastructure in the future energy system framework. The objective should be an optimized interplay of various energy vectors and their infrastructure along the entire energy supply chain. This requires a level playing field for different renewable technologies across different policy areas and a form of public support that strikes the balance between facilitating the gradual substitution of natural gas by renewable gas while maintaining public acceptance for this transformation despite higher costs for end-users.: Given the societal benefits and the competitiveness of renewable gas as compared to renewable alternatives, energy policy makers should incorporate renewable gas and the existing gas infrastructure in the future energy system framework. The objective should be an optimized interplay of various energy vectors and their infrastructure along the entire energy supply chain. This requires a level playing field for different renewable technologies across different policy areas and a form of public support that strikes the balance between facilitating the gradual substitution of natural gas by renewable gas while maintaining public acceptance for this transformation despite higher costs for end-users.

Preprint ARTICLE | doi:10.20944/preprints201803.0088.v1

Integrating Monte Carlo and the Hydrodynamic Model for Predicting Extreme Water Levels in River Systems

Wen-Cheng Liu, Hong-Ming Liu

Subject: Engineering, Civil Engineering Keywords: extreme water level; hydrodynamic model; Monte Carlo; joint probability; model calibration and verification; Danshuei River system

Online: 12 March 2018 (07:56:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.1867.v1

The Sentinel Sleep Theory: The Biological Function of REM Sleep Unveiled

Raffael Spinassi

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: REM sleep; N-REM sleep; Theory; Scientific theory; Biological function; Evolution; Evolutionary biology; Evolutionary origin; Historical narrative

Online: 27 August 2024 (13:12:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0732.v1

Block Copolymers of Poly(N-Vinyl Pyrrolidone) and Poly(Vinyl Esters) Bearing N-alkyl Side-Groups via RAFT Polymerization Synthesis, Characterization and Thermal Properties

Nikoletta Roka, Panagiota Theodosia Papazoglou, Marinos Pitsikalis

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: poly(N-vinyl pyrrolidone) (NVP); poly(vinyl esters) (VEs); block copolymers; RAFT polymerization, thermal analysis; thermal stability

Online: 12 August 2024 (04:37:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0092.v4

Chemicals in Essential Oils of Phlomoides rotata (Benth. ex Hook. f.) Mathiesen and Their Antioxidant Activities Potential

Zheng Pan, Chen Xie, Xiao Tong Yan, Yong Mei Su, Anwar Ul Haq, Jian Wang

Subject: Medicine And Pharmacology, Pharmacy Keywords: Phlomoides rotata (Benth. ex Hook. f.) Mathiesen; Lamiophlomis rotata (Benth.) Kudô; essential oils; fatty acids; n-hexadecanoic acid (palmitic acid); chemical markers; antioxidant activities

Online: 28 August 2023 (08:27:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1361.v1

NOTCH, SUMOylation and ESR-Mediated Signalling Are the Main Molecular Pathways Showing Significantly Different Epimutation Score Between Expressing or not Estrogen Receptor Breast Cancer in Three Public EWAS Datasets

Luigi Corsaro, Vincenzo Sandro Gambino

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: n/a; epimutation score; breast cancer; EWAS; stochastic epimutation; methylation; epigenetic association study; epimutation; NOTCH; SUMO; ESR

Online: 19 June 2023 (13:09:54 CEST)

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Oestrogen receptor expression in breast cancer (BC) cells is a marker of high cellular differentiation and allows the identification of two BC groups (ER-positive and ER-negative) that, although not completely homogeneous, differ in biological characteristics, clinical behaviour and therapeutic options. The study, based on three publicly available EWAS datasets, focuses on the comparison between these two groups of breast cancer using an epimutation score. The score is calculated not only based on the presence of the epimutation but also on the deviation amplitude of the methylation outlier value. For each dataset, we performed a functional analysis based first on the functional gene region of each annotated gene (we aggregated the data per gene region TSS1500, TSS200, first-exon, body-gene identified by the information from the Illumina Data Sheet) and then we performed a pathway enrichment analysis through the REACTOME database based on the genes with the highest epimutation score. Thus, we blended our results and found common pathways for all three data sets. We found that a higher and significant epimutation score due to hypermethylation in ER-positive BC is present in the promoter region of the genes belonging to the SUMOylation pathway, the NOTCH pathway, the IFN-$\gamma$ signalling pathway and the deubiquitination protease pathway; while a higher and significant level of epimutation due to hypomethylation in ER-positive BC is present in the promoter region of the genes belonging to the ESR-mediated pathway. The presence of this state of promoter hypomethylation in the ESR-mediated signalling genes is consistent and coherent with an active signalling pathway mediated by oestrogen function in the group of ER-positive BC. SUMOylation and NOTCH pathways are associated with BC pathogenesis and have been found to play distinct roles in the two BC subgroups. We speculated that the altered methylation profile may play a role in regulating signalling pathways with specific functions in the two subgroups of ER-BC.

Preprint ARTICLE | doi:10.20944/preprints202104.0276.v1

Basic Modifications of "Floating" Differential Stages Based on Complementary Field-Effect Transistors with a Control p-n Junction

Vladislav Chumakov, Nikolay Prokopenko, Ilja Pakhomov, Alexey Titov

Subject: Engineering, Automotive Engineering Keywords: log microcircuit; differential stage; complementary field-effect transistors with control p-n junction; low temperatures; neutron flux

Online: 12 April 2021 (09:40:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0360.v3

Algebraic Rules for the Percentage Composition of Oligomers in Genomes

Sergey Petoukhov

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: DNA alphabets, genomes, percentages of n-plets, binary-oppositions, tensor family of matrices, tetra-groupings, quantum biology, algebraic holography.

Online: 23 June 2021 (11:49:51 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202007.0174.v2

Cracking the Secret Code of the Selectivity Ratio Between K⁺ and Na⁺ Ions in the KcsA K⁺ Channel

Yongwoon Jung, Sangyong Nam

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: KcsA K+ channel; K+ ion and N+ ion; Selectivity Filter; Snug-fit Mechanism; Selectivity Ratio; Brownian Dynamics

Online: 3 August 2020 (04:57:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0327.v1

Truncations of W∞ Algebras

Mohammed Akram Fellah

Subject: Physical Sciences, Mathematical Physics Keywords: Vertex Algebras on the corner; the GL-twisted N=4 Super Yang Mills gauge theory; W∞ Algebras

Online: 23 March 2020 (01:45:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0504.v1

A General Theorem on the Stability of a Class of Functional Equations including Quartic-Cubic-Quadratic-Additive Equations

Yang-Hi Lee, Soon-Mo Jung

Subject: Computer Science And Mathematics, Analysis Keywords: generalized Hyers-Ulam stability; functional equation; $n$-dimensional quartic-cubic-quadratic-additive type functional equation; direct method

Online: 22 October 2018 (14:29:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201706.0132.v1

In Silico Screening and Analysis of Potential Inhibitors of Arylamine N-Acetyltransferases (NATs) from the Traditional Chinese Medicine: A Study Using Free Available Tools

Francisco Azevedo, Joveline Richardt, Mayrla Oliveira, Inês Araujo, Ricardo Oliveira, Luis Baptista, Hermes Amorim

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: arylamine N-acetyltransferases; cancer; tuberculosis; drug discovery; traditional Chinese medicine; virtual screening; molecular dynamics simulation; MM-PBSA

Online: 30 June 2017 (11:36:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.0724.v1

Design and Analysis of A Triple-Input Three-Level PV Inverter with Minimized Number of MPPT Controllers

Bikash Gyawali, Rukhsar ., Aidha Muhammad Ajmal, Yongheng Yang

Subject: Engineering, Electrical And Electronic Engineering Keywords: Maximum power point tracking; photovoltaic (PV) power systems; Triple-input; three-phase; three-level; quasi-Z-source

Online: 10 October 2024 (10:15:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.0695.v1

Using IoT for Cistern and Water Tank Level Real-Time Monitoring

Miguel A. Wister, Ernesto Leon, Alejandro Alejandro-Carrillo, Pablo Pancardo, Jose A Hernandez-Nolasco

Subject: Engineering, Other Keywords: IoT; Internet of Things; water flow sensor; water level sensor; water quality sensor; water-saving; water tank

Online: 9 October 2024 (13:01:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1764.v1

A Comprehensive Analysis of Ground-Level Concentrations of Aerosols and Criteria Pollutants Using the CAMS Reanalysis Dataset over the Himawari-8 Observational Area, including China, Indonesia, and Australia (2016-2023)

Miles Sowden

Subject: Environmental And Earth Sciences, Pollution Keywords: CAMS Reanalysis; Ground-Level Concentrations (GLCs); Geographic Weighted Regression (GWR); Jacobian Matrix; Data Normalization; Spatiotemporal Analysis; Aerosol

Online: 26 June 2024 (00:09:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.1826.v1

How to Design and Analyze Efficient Cluster Randomized Controlled Trials: A Review and Recent Development in Low and Middle-Income Countries

Amanuel Yoseph

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: cluster randomized controlled trial; variance inflation factor; interclass correlation; multi-level analysis; public health research; effect modification

Online: 27 December 2023 (05:36:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0590.v1

Multi-level Perceptions on Higher Education Development for Sanitation and Hygiene Management in Nigeria

Peter Emmanuel Cookey, Mayowa Abiodun Peter-Cookey, Richard Iloma Unwobuesor, Damir Brdanovic

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Skills; Knowledge and Competency; Multi-Level Perception; Sanitation/Hygiene Management; Higher Education Institutions; Environmental Health Technician/Technology

Online: 11 October 2023 (06:55:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0063.v1

Diagnostic Assessment in Wet and Dry Seasons of Simple Weirs Constructed by Small-scale Farmers in the Northern Region Provinces of Zambia

Alex Lushikanda KABWE, Masahiro HYODO, Hidehiro OGATA, Yoshihiro SAGAWA, Yoshinao ADACHI, Masayuki ISHII

Subject: Engineering, Other Keywords: ingle-line weir; small-scale irrigation; river diversion; rural areas; up-stream wa-ter level; emerging farmers

Online: 2 October 2023 (09:52:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0279.v1

A Systematic Study on Layer-Level Multi-Material Fabrication of Parts by Laser-Powder Bed Fusion Process

Andrea Angelastro, Paolo Posa, Vito Errico, Sabina Luisa Campanelli

Subject: Engineering, Mechanical Engineering Keywords: additive manufacturing; laser-powder bed fusion; functionally graded materials; multi-material layer-level; nickel superalloy; stainless steel.

Online: 3 August 2023 (10:22:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1971.v1

Small-scale marine fishers’ possession of fishing vessel and its impact to their net income level: A Case Study in Takalar District, South Sulawesi Province of Indonesia

Ahmad Imam Muslim, Miho Fujimura, Tsuji Kazunari, Muslim Salam

Subject: Business, Economics And Management, Economics Keywords: Small-scale fisher, Fishers’ boat, Net income level of fishers, Row boat, Outboard motor boat, Motor boat

Online: 28 July 2023 (11:44:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0361.v1

Child ViReal Support Program: A Randomized Controlled Trial Study for Effective Support of Parents Raising Children with Attention Deficits

Iouliani Pachiti, Fotios S. Milienos, Panagiota Dimitropoulou

Subject: Social Sciences, Psychology Keywords: attention deficits; ADHD; multi-level interventions; RCT; psychoeducation; parent training; parenting stress; parental self-efficacy; parenting styles

Online: 6 July 2023 (09:12:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints202205.0227.v1

The Imprint of Recent Meteorological Events on Boulder Deposits along the Mediterranean Rocky Coasts

Marco Delle Rose, Paolo Martano

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: Coastal storm; Wind wave; Storm surge; Extreme coastal water level; Boulder dynamics; Geomorphological proxy; Interdisciplinary climate research

Online: 17 May 2022 (10:28:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0283.v1

Particulate Matter Measurement with Low-Cost Sensors—Investigation of Data Quality and the Benefit of Data Correction Approaches

Tobias von Kuyck-Studzinski, Thoralf Buller, Alexander Conrad

Subject: Environmental And Earth Sciences, Environmental Science Keywords: fine dust measurement (PM2.5, PM10); LoRaWAN; internet of things; low-cost sensors; SDS011; level-indication measurements; sustainability

Online: 22 February 2022 (20:10:59 CET)

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Preprint REVIEW | doi:10.20944/preprints202107.0227.v3

A Review of Groundwater Management Models with a Focus on IoT-Based Systems

Banjo Aderemi, Thomas Otieno Olwal, Julius Musyoka Ndambuki, Sophia Sudi Rwanga

Subject: Engineering, Control And Systems Engineering Keywords: Internet of Things (IoT); groundwater level; groundwater resource; groundwater management models; groundwater monitoring system; wireless sensor network

Online: 28 December 2021 (12:10:17 CET)

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Preprint REVIEW | doi:10.20944/preprints202112.0185.v1

Higher-Level Executive Functions in Mild Cognitive Impairment: A Systematic Review

Ilaria Corbo, Maria Casagrande

Subject: Social Sciences, Cognitive Science Keywords: Mild Cognitive Impairment; Ageing; Elderly; Executive Functions; Higher-Level Executive Functions; Planning; Reasoning; Fluid Intelligence; Problem Solving

Online: 10 December 2021 (13:37:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0195.v1

Relationship between Measured Aerobic Capacity and Total Energy Expenditure Obtained by Doubly Labeled Water in Community-Dwelling Healthy Adults Aged 81-94y: A Preliminary Study

Jun Yasukata, Yosuke Yamada, Hiroyuki Sagayama, Yasuki Higaki, Hiroaki Tanaka

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: doubly labeled water; total energy expenditure; physical activity level; lactate threshold, physical fitness; International Physical Activity Questionnaire

Online: 7 April 2021 (11:32:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0112.v1

Uvaol Exerts Anti-Proliferative and Pro-Apoptotic Effects on Human Hepatocarcinoma Cells by Modulating AKT/PI3K Signaling Pathway

Gloria C. Bonel-Pérez, Amalia Pérez-Jiménez, Isabel Gris-Cárdenas, Alberto M. Parra-Pérez, José Antonio Lupiáñez, Fernando J. Reyes-Zurita, Eva Siles, René Csuk, Juan Peragón, Eva E. Rufino-Palomares

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: AKT/PI3K signaling pathway; apoptosis; human hepatocarcinoma HepG2 cells; migration activity; proliferation; oxidative stress; ROS level; uvaol

Online: 5 August 2020 (05:58:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0630.v1

Preparing for Sea-Level Rise through an Adaptive Managed Retreat of a Two-Waters Network

Rick Kool, Judy Lawrence, Martin Drews, Robert Bell

Subject: Engineering, Civil Engineering Keywords: managed retreat; dynamic adaptive policy pathways; sea-level rise; water infrastructure; stormwater; wastewater; coastal flooding; climate change

Online: 26 July 2020 (02:38:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201909.0236.v1

The capability Enhancement of DC-link Voltage Using ARPI Controller for Single-Stage Grid-Connected PV System

Ayman Alhejji

Subject: Engineering, Electrical And Electronic Engineering Keywords: arpi; p&o-based mppt; variable dc-link; single-stage; three-level three-phase inverter; grid connection

Online: 20 September 2019 (10:35:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints201908.0196.v1

Satellite Remote Sensing of the Greenland Ice Sheet Ablation Zone: A Review

Matthew G. Cooper, Laurence C. Smith

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: ablation zone; Greenland; ice sheet; surface mass balance; mass balance; altimetry; albedo; scatterometry; lidar; sea level rise

Online: 20 August 2019 (02:55:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0337.v1

An Integrated View of Greenland Ice Sheet Mass Changes Based on Models and Satellite Observations

Ruth Mottram, Sebastian B. Simonsen, Synne Høyer Svendsen, Valentina R. Barletta, Louise Sandberg Sørensen, Thomas Nagler, Jan Wuite, Andreas Groh, Martin Horwarth, Job Rosier, Rene Forsberg

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: essential climate variables (ECV); climate change initiative (CCI); Greenland ice sheet; mass budget; cryosphere; sea level rise

Online: 16 October 2018 (07:53:22 CEST)

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The Greenland ice sheet is a major contributor to sea level rise, adding an estimated 0.47 +/− 0.23 mm/yr to global mean sea level between 1991 and 2015 (van den Broeke et al., 2016). Making sea level rise projections for the future and understanding the processes controlling current observed rates of sea level rise are crucially dependent on understanding the present-day state of the ice sheet. Here, we provide an overview of the current state of the mass budget of Greenland based on satellite gravimetry and remote sensing observations of surface elevation change, ice sheet velocity and calving front positions. We also combine these essential climate variables with a regional climate model (RCM) output from an ice sheet model (ISM) to gain insight into poorly understood ice sheet dynamical and surface mass processes. On average from 1992 to 2017 the ice sheet in some locations has lost up −2.65 m/yr in elevation based on ESA Radar altimetry analysis. Calving fronts have retreated all around Greenland since the 1990s and in only two out of 28 study locations have they remained stable. The locations of grounding lines at 5 key glaciers with floating ice tongues have remained stable over the observation period. However a detailed case study at Petermann glacier with an ice fracture model shows the sensitivity of these floating ice shelves to future climate change. GRACE gravimetric mass balance (GMB) data allows us to tie together disparate lines of evidence showing that Greenland has lost about 265 +/− 25 Gt/yr of ice over the period 2002 to 2015. RCM and ISM simulations show that surface mass processes dominate the overall Greenland ice sheet mass budget except for areas of fast ice sheet flow but marked differences between models and between models and observations indicate that not all processes are captured accurately, indicating areas of greater uncertainty and directions of future research for future sea level rise projections.

Preprint ARTICLE | doi:10.20944/preprints201808.0301.v1

Estimation of Salinity Intrusion by Using Landsat 8 OLI Data in The Mekong Delta, Vietnam

Phuong Ha Tran, Anh Kim Nguyen, Yuei-An Liou, Phung Phi Hoang, Hung Thanh Nguyen

Subject: Environmental And Earth Sciences, Geography Keywords: Salinity intrusion; climate change; rising sea level; electrical conductivity; Landsat 8 OLI; Tra Vinh Province; Mekong Delta

Online: 17 August 2018 (11:41:14 CEST)

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Salinity intrusion is one of the most serious consequences of climate change coupled with rising sea level that significantly affects agricultural activities in many parts of the world. This phenomenon has increasingly become more serious and frequently occurred in the Mekong Delta of Vietnam. As a result, Vietnam has been ranked among top five countries where have been devastatingly impacted by climate change, in particular, its Tra Vinh Province characterized by coastal plain and alluvial deposit. In addition, this area is of the tropical monsoon zone of long rainy season with source of salt brought from the sea by the tides and sea level rise. Regions that are contaminated by salt are located in lowland and often suffer from floods linking to tidal effects with salty water from river systems and channels. Soil salinity evaluation is critical for coastal protection, restoration, and agricultural planning since it can be considered as an agricultural indicator to evaluate quality of soil. Here, we attempt to estimate the soil salinity in Tra Vinh Province, in the Mekong Delta of Vietnam. Landsat 8 OLI images are utilized to derive indices for soil salinity evaluation including single bands, Vegetation Soil Salinity Index (VSSI), Soil Adjusted Vegetation Index (SAVI), Normalized Difference Vegetation Index (NDVI), and Normalized Difference Salinity Index (NDSI). Subsequently, satistical analysis between soil salinity, electrical conductivity (EC, dS/m), and environmental indices derived from Landsat 8 OLI image is performed. Results indicate that spectral value of Near Infrared (NIR) band and VSSI are highly correlated with EC (R2 = 0.7779 and R2 = 0.6957, respectively) in comparison with the other indices. Comparative results show that soil salinity derived from Landsat 8 is consistent with in situ data. Findings of this study demonstrate that Landsat 8 OLI images reveal a high potential for spatiotemporally monitoring the magnitude of soil salinity at the top soil layer. Outcomes of this study are useful for agricultural activities, planners, and farmers by providing the base map of soil salinity contamination for better selection of accomodating crop types to reduce economical lost in the context of climate change. Our proposed method that estimates soil salinity using satellite-derived variables can be applied in the other regions.

Preprint ARTICLE | doi:10.20944/preprints201805.0010.v3

Sustainability as Source of Competitive Advantages in Mature Sectors: The Case of Ceramic District of Sassuolo (Italy)

Davide Settembre-Blundo, Fernando E. García-Muiña, Martina Pini, Lucrezia Volpi, Cristina Siligardi, Anna Maria Ferrari

Subject: Social Sciences, Decision Sciences Keywords: sustainability; competitive advantage, Sassuolo tile ceramic district; Life Cycle Sustainability Assessment (LCSA); Italian ceramic industry; meso-economic level; interpretative method

Online: 13 June 2018 (09:49:25 CEST)

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Talking about sustainable development refers mainly to the environmental sphere, but the concept is much broader and also takes into account the social and economic conditions. The concept of sustainability, in this sense, is linked to the compatibility between the development of economic activities, the related social phenomena, and the protection of the environment. Therefore, the ability to balance social, economic and environmental sustainability is the very meaning of the concept of sustainable development. Firms that choose to develop policies and strategies to enhance and pursue sustainable development in the medium to long term have the burden of having to quantitatively document the improvements in production processes with the aim of sustainable development. As a result, one of the biggest challenges for European industry is to introduce sustainability principles into business models leading to competitive advantage. This is particularly important in raw material and energy intensive manufacturing sectors such as the ceramic industry. The present state of knowledge lacks a comprehensive operational tool for industry to support decision-making processes geared towards sustainability. In the ceramic sector, the economic and social dimensions of the product and processes have not yet been given sufficient importance. Moreover, the traditional research on industrial districts lacks an analysis of the relations between firms and the territory with a view to sustainability. Finally, the attention of scholars in the field of economic and social sustainability, has not yet turned to the analysis of the Sassuolo district. Therefore, in this paper we introduce the Life Cycle Sustainability Assessment (LCSA), as a method that can be a suitable tool to fill this gap, because through a mathematical model it is possible to obtain the information useful for decision makers to integrate the principles of sustainability both at the microeconomic level in enterprises, and at the meso-economic level for the definition of economic policies and territorial governance. Environmental and socio-economic analysis was performed from the extraction of raw materials to the packaging of the product on different product categories manufactured by the Italian ceramic industries of the Sassuolo district (northern Italy). For the first time the LCSA model, usually applied to unitary processes, is extended to the economic and industrial activities of the entire district, extending the prospect of investigation from the enterprise and its value chain to the integrated network of district enterprises.

Preprint ARTICLE | doi:10.20944/preprints201810.0073.v1

Classification for Liver Diseases Based on Ultrasound Image Texture Features

Sendren Sheng-Dong Xu, Chien-Tien Su, Chun-Chao Chang, Pham Quoc Phu

Subject: Medicine And Pharmacology, Other Keywords: Classification; F-score; Gray-Level Co-occurrence Matrix (GLCM); Gray-Level Run-Length Matrix (GLRLM); Hepatocellular Carcinoma (HCC); Liver Cancer; Liver Abscess; Image Texture, Sequential Backward Selection (SBS); Sequential Forward Selection (SFS); Support Vector Machine (SVM); Ultrasound Image.

Online: 4 October 2018 (14:01:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.1087.v1

Functional Nano-Metallic Coatings for Solar Cells

Witold Aleksander Jacak

Subject: Physical Sciences, Optics And Photonics Keywords: metallic nanoparticles; surface plasmons; damping of plasmons; nano-metallic coatings; perovskite solar cells; p-n junction solar cells

Online: 14 October 2024 (14:45:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1830.v1

Nanopriming With Zinc-Molybdenum in Jalapeño Pepper on Imbibition, Germination and Early Growth

Erick Humberto Ochoa-Chaparro, Carlos Abel Ramírez-Estrada, Julio César Anchondo-Paez, Esteban Sánchez, Sandra Pérez-Alvarez, Luis Ubaldo Castruita-Esparza, Ezequiel Muñoz-Márquez, Celia Chávez-Mendoza, Juan José Patiño-Cruz, Cristina Larissa Franco-Lagos

Subject: Biology And Life Sciences, Horticulture Keywords: Capsicum annuum L.; nanocebado; bebida; germinació; n; crecimiento temprano; í; ndice de vigor; zinc-molibdeno

Online: 26 June 2024 (06:18:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.1955.v1

Preparing for patient-customized N-of-1 Antisense Oligonucleotide Therapy to Treat Rare Diseases

Harry Wilton-Clark, Eric Yan, Toshifumi Yokota

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Antisense oligonucleotide; N-of-1; milasen; atipeksen; valeriasen; rare disease; exon skipping; splice switching; personalized medicine; muscular dystrophy

Online: 29 May 2024 (12:08:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0687.v1

New Infinite Classes for Normal Trimagic Squares of Even Orders Using Row-Square Magic Rectangles

Can Hu, Fengchu Pan

Subject: Computer Science And Mathematics, Discrete Mathematics And Combinatorics Keywords: n/a; Trimagic square; row-square magic rectangle; trimagic pair; product construction; diagonal Latin square; hypergraph; magic labeling

Online: 12 March 2024 (08:27:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.1314.v1

Evaluating Interfacial Layer Thickness from Phonon Characteristics of Novel Carbon-Based Strained Superlattices

Devki N. Talwar, P Becla

Subject: Physical Sciences, Condensed Matter Physics Keywords: novel (SiC)m/(GeC)n superlattices; interfacial layer thickness; raman intensity profiles; lattice dynamics; localization of atomic displacements

Online: 19 July 2023 (10:07:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0123.v1

Evaluating Critical Nitrogen Dilution Curves for Assessing Maize Nitrogen Status across the US Midwest

Hui Shao, Yuxin Miao, Fabián G. Fernández, Newell Kitchen, Curtis Ransom, James J. Camberato, Paul R. Carter, Richard B. Ferguson, David W. Franzen, Carrie A. M. Laboski, Emerson D. Nafziger, John E. Sawyer, John Shanahan

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: critical nitrogen dilution curve; nitrogen nutrition index; soil nitrate-N content; crop nitrogen status diagnosis; precision nitrogen management

Online: 3 July 2023 (15:39:57 CEST)

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Plant N concentration (PNC) has been commonly used to guide farmers in assessing maize (Zea mays L.) N status and making in-season N fertilization decisions. However, PNC varies based on the development stage and therefore a relationship between biomass and N concentration is needed (i.e., critical N dilution curves; CNDC) to better understand when plants are N deficient. A few CNDC have been developed and used for plant N status diagnoses, but have not been tested in the US Midwest. The objective of this study was to evaluate under highly diverse soil and weather conditions in the US Midwest the performance of CNDCs developed in France and China for assessing maize N status. Maize N rate response trials were conducted across eight US Midwest states over three years. This analysis utilized plant and soil measurements at V9 and VT development stages and final grain yield. Results showed that the French CNDC (y=34.0x-0.37, where y is critical PNC, x is aboveground biomass) was better with a 91% N status classification accuracy compared to only 62% with the Chinese CNDC (y=36.5x-0.48). The N nutrition index (NNI), which is the quotient of the measured PNC and the calculated critical N concentration (Nc), based on the French CNDC was significantly related to soil nitrate-N content (R2=0.38-0.56). Relative grain yield on average reached a plateau at NNI values of 1.36 at V9 and 1.21 at VT, but for individual sites ranged from 0.80 to 1.41 at V9 and from 0.62 to 1.75 at VT. The NNI threshold values or ranges optimal for crop biomass production may not be optimal for grain yield production. It is concluded that the CNDC developed in France is suitable as a general diagnostic tool for assessing maize N status in US Midwest. However, the threshold values of NNI for diagnosing maize N status and guiding N applications vary significantly across the region, making it challenging for guiding specific on-farm N management. More studies are needed to determine how to effectively use CNDC to make in-season N recommendations in the US Midwest.

Preprint ARTICLE | doi:10.20944/preprints202306.1272.v1

Visible-Light-Induced Photocatalytic Degradation of Rhodamine B Dye Using CuS/ZnS P-N Heterojunction Nanocomposite under Visible Light Irradiation

Rachel Mugumo, Emmanuel Ichipi, Shepherd M. Tichapondwa, Evans M. Nkhalambayausi Chirwa

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: CuS/ZnS; photocatalytic degradation; p-n heterojunction; thermal decomposition; one-pot combustion; rhodamine B dye; visible light irradiation

Online: 19 June 2023 (03:31:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0357.v1

Phosphorylation Mimetic of Myosin Regulatory Light Chain Mitigates Cardiomyopathy-induced Myofilament Impairment in Mouse Models of RCM and DCM

Katarzyna Kazmierczak, Jingsheng Liang, Luis Guillermo Maura, Natissa Kelsey Scott, Danuta Szczesna-Cordary

Subject: Biology And Life Sciences, Life Sciences Keywords: Cardiomyopathy; myosin RLC; myosin ELC; N-terminal protein modification, S15D-RLC phosphomimetic, super-relaxed state (SRX); Tg mice

Online: 5 June 2023 (16:43:56 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202202.0036.v1

Home-Field Advantage of Litter Decomposition Faded 5-10 Years After Spruce Forest Clearcutting

Liyan Zhuang, Andrea Schnepf, Kirsten Unger, Ziyi Liang, Roland Bol

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Clearcutting; Norway spruce; European beech; litter decomposition; N; Ca; Home-field advantage (HFA); Carbon and nitrogen stable isotopes

Online: 2 February 2022 (13:49:41 CET)

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Preprint REVIEW | doi:10.20944/preprints202102.0277.v1

Oligodendroglial Energy Metabolism and (re) Myelination

Vanja Tepavcevic

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: energy metabolism; oligodendrocyte; oligodendrocyte progenitor cell; myelin; remyelination; multiple sclerosis; glucose; ketone bodies; lactate; N-acetyl aspartate; demyelination

Online: 11 February 2021 (10:57:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.0512.v1

Evidence On Viral Suppression Supports Scaling-Up Transition To Dolutegravir-Based Regimens In Pediatric Populations In Cameroon: A Multicentre Baseline Assessment For The Cipher-Adola Study

Joseph FOKAM, Yagai Bouba, Rogers Awoh Ajeh, Dominik Tameza Guebiapsi, Suzane Essamba, Albert Franck Zeh Meka, Ebiama Lifanda, Rose Armelle Ada, Yakouba Liman, Nancy Barbara Mbengono, Audrey Raissa Dzaddi Djomo, Suzie Ndiang Tetang, Samuel Martin Sosso, Jocelyne Carmen Babodo, Olivia Francette Ndomo Ambomo, Edith Michele Temgoua, Caroline Medouane, Sabine Ndejo Atsinkou, Justin Leonel Mvogo, Roger Martin Onana, Jean de Dieu Anoubissi, Alice Ketchaji, Alex Durand Nka, Davy-Hyacinthe Anguechia Gouissi, Aude Christelle Ka’e, Nadine Nguendjoung Fainguem, Rachel Simo Kamgaing, Désiré Augustin Komego Takou, Michel Carlos Tommo Tchouaket, Ezechiel Ngoufack Jagni Semengue, Marie Atsama Amougou, Julius Nwobegahay, Comfort Vuchas, Anna Nya Nsimen, Bertrand Bille Eyoum, Sandra kenmegne Gatchuessi, Francis Ndongo Ateba, Daniel Kesseng, Serge Clotaire Billong, Daniele Armenia, Maria Mercedes Santoro, Francesca Ceccherini-Silberstein, Paul Ndombo Koki, Hadja Cherif Hamsatou, Vittorio Colizzi, Alexis Ndjolo, Carlo Federico Perno, Anne-Cécile Zoung-Kanyi Bissek

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Virological suppression; low level viremia; children, adolescents, and young-adults; DTG-based regimen; elimination of paediatric AIDS; Cameroon.

Online: 5 July 2024 (12:31:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0132.v1

A Chip-Level Testing Platform of Unmanned Vehicle Autopilot Systems with FPGA-Based Hardware-in-the-Loop Simulation

Xunhua Dai, Ruyi Fang

Subject: Engineering, Control And Systems Engineering Keywords: unmanned vehicles; autopilot systems; chip-level faults; hardware-in-the-loop (HIL) simulation; Field Programmable Gate Array (FPGA)

Online: 4 March 2024 (13:57:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1325.v1

A Contribution to Understanding Damage Generated and Propagated by the AAR Reactive Aggregate from Kingston, Ontario, Canada

Cassandra Trottier, Leandro F.M. Sanchez

Subject: Engineering, Civil Engineering Keywords: alkali-aggregate reaction; alkali-carbonate reaction; internal swelling reaction; multi-level assessment; damage rating index; semi-quantitative microscopy

Online: 22 November 2023 (07:48:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1165.v1

Groundwater Level Prediction with Machine Learning to Support Sustainable Irrigation in Water Scarcity Regions

Wanru Li, Mekuanent Muluneh Finsa, Kathryn Blackmond Laskey, Paul Houser, Rupert Douglas-Bate

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: machine learning; groundwater table; ground water level; sustainable irrigation; drinking water; water-scarcity regions; AI; gradient boosting regression

Online: 18 September 2023 (14:50:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0577.v1

Global Evidence of Obliquity Damping in Climate Proxies and Sea-Level Record during the Last 1.2 Ma: A Missing Link for the Mid-Pleistocene Transition

Paolo Viaggi

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: mid-pleistocene transition; obliquity–oblateness feedback; obliquity damping hypothesis; water- mass redistribution; glacio-eustatic sea level; short eccentricity

Online: 8 September 2023 (13:07:04 CEST)

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A recent research has identified an inverse amplitude link between obliquity damping and short eccentricity amplification during Mid-Late Pleistocene based on LR04 δ18O and equatorial Pacific Site 846 sea surface temperature records, which is associated with the Earth's long-term cooling. In the present study, new evidence of this anticorrelation is presented from Antarctic D-CO2-CH4 records, global benthic-planktic δ18O, and regional (Atlantic, Pacific, Mediterranean, and Indian) climate-related proxies. Based on a critical review of theoretical constrains (Earth's oblateness changes and ice-volume phase lag in the obliquity band <5.0 kyr), this widespread and symmetric (bipolar) obliquity response damping has been interpreted as an effect of the obliquity-oblateness feedback, which could be the latent physical mechanism at the origin of the Mid-Pleistocene Transition (MPT). Indeed, results and considerations of the present work suggest that fast and positive/negative net variation of the Earth's oblateness in the obliquity band was controlled by dominant glacio-eustatic water mass component and, assuming a rapid response of the ice-volume to surface temperature changes, the mean obliquity lag response is estimated to be <5.0 kyr over the past 800 kyr. These elements may explain the interglacial/glacial damping observed in the obliquity response. The consolidation of the Earth's long-term icy-state in the subtrend IV, culminated with the post-MPT obliquity damping, might have contributed to the strengthening of the short eccentricity response by mitigating the obliquity ‘ice-killing’ during obliquity maxima (interglacials), favouring the obliquity-cycle skipping and a feedback amplified ice-growth in the short eccentricity band (obliquity damping hypothesis). This could suggest a different impact of the climate friction than what is generally believed, which is presumably the latent physical mechanism that triggers transient ‘competitive’ interaction between obliquity and short eccentricity started early during the Piacenzian.

Preprint TECHNICAL NOTE | doi:10.20944/preprints202211.0220.v2

SG-ColBase: A Relational Column Database Kernel

Tong Zhou, Tingzhen Liu

Subject: Computer Science And Mathematics, Information Systems Keywords: Relational Database; Columnar Storage; Bloom Filter; Skip List; Field Level Lock; Read Write Concurrency; OLTP; OLAP; LSM-Tree; Token Bucket Algorithm

Online: 14 November 2022 (03:02:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0359.v1

Cultural Sustainability: Investigating User Preferences for Retail Lighting Conditions

Kumar Hemalatha, Irulappan Chandramathy, Radhakrishnan Shanthi Priya, Amardeep M. Dugar

Subject: Social Sciences, Sociology Keywords: cultural sustainability; inclusive design; retail space; illuminance level; correlated colour temperature (CCT); spatial impression; user preference; Indian context

Online: 28 March 2022 (09:45:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0221.v1

Evaluation of the Severity of Major Depression Using a Voice Index for Emotional Arousal

Shuji Shinohara, Hiroyuki Toda, Mitsuteru Nakamura, Yasuhiro Omiya, Masakazu Higuchi, Takeshi Takano, Taku Saito, Masaaki Tanichi, Shuken Boku, Shunji Mitsuyoshi, Mirai So, Aihide Yoshino, Shinich Tokuno

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: arousal level; emotion; major depression severity; voice index; Hurst exponent; zero-crossing rate; Hamilton Rating Scale for Depression

Online: 9 August 2020 (21:15:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0155.v1

CORINE Land Cover Data and Actual Arrangement of Buildings in Research on Processes of Concentration and Dispersion of Settlement: Example of Poland

Paweł Sudra

Subject: Environmental And Earth Sciences, Other Keywords: CLC 2018 level of detail; comparison of remote sensing and geodetic data; settlement; land use monitoring; urban sprawl

Online: 9 May 2020 (08:22:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201709.0005.v2

An Application-Oriented Design Method for Networked Driving Simulation

Kareem Abdelgawad, Jürgen Gausemeier, Ansgar Trächtler, Sandra Gausemeier, Roman Dumitrescu, Jan Berssenbrügge, Jörg Stöcklein, Michael Grafe

Subject: Engineering, Automotive Engineering Keywords: autonomous and cooperative vehicle systems; connected driving simulators; systems engineering; system of systems; system-level design; application-oriented development

Online: 12 September 2017 (15:32:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201609.0085.v2

Modeling and Simulation of Passenger Flow Distribution in Urban Rail Transit Hub Platform

Long Gao, Limin Jia

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: passenger flow distribution model; simulation design; performance evaluation; passenger flow volume; service level; urban rail transit hub platform

Online: 2 December 2016 (07:52:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.1163.v1

An Analysis Comparing the Taguchi Method for Optimizing the Process Parameters of AA5083/Silicon Carbide and AA5083/Coal Composites That Are Fabricated via FSP

Oritonda Muribwathoho, Velaphi Msomi, Sipokazi Mabuwa

Subject: Engineering, Mechanical Engineering Keywords: Aluminium alloys; Composite; Metal Matrix Composite; Mechanical Properties; Friction Stir Welding; Friction Stir Processing; Taguchi; S/N Ratio; ANOVA

Online: 16 September 2024 (10:00:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2080.v1

Ecological Control of Aphids in Mandarins With Pyroligneous Acid Derived From Biomass

Jorje Valverde Enriquez, Orlando Meneses Quelal, Jenny Yambay Vallejo

Subject: Environmental And Earth Sciences, Other Keywords: Á; cido piroleñ; oso; Mandarina; Pulgones; Agricultura ecoló; gica; Destilació; n seca; Piró; lisis; Horno

Online: 26 July 2024 (05:55:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1853.v1

Enumeration of N-dimensional Hypercube, Icosahedral, Rubik’s Cube Dice, Colorings and Encryptions Based on Their Symmetries

Krishnan Balasubramanian

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: Monte Carlo Enumeration of n-dimensional dice; icosahedral and hypercubic symmetries; buckminsterfullerene; mesoporous and zeolite materials; isochiral polyhedra; cryptography

Online: 24 July 2024 (15:56:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0633.v2

A Revolution in Quantum Computing is Underway: the Essence-Units and Energy States are Fundamental Programming Units

Alexander Rybalov, Michael Naich

Subject: Computer Science And Mathematics, Other Keywords: quantum dot; Tsallis entropy; Renyi entropy; quantum computer; fractal dimension; distortion; information processing; N-dimensional programming unit; electric field

Online: 15 July 2024 (04:54:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1544.v1

Model Hierarchy to Reanalyze Results from an Archetypical Experiment on the Kinetics of Heterogeneous Nucleation – the Electrodeposition of Hg on Pt, by I. Markov and E. Stoycheva

Viktoria Kleshtanova, Vasil Ivanov, Feyzim Hodzhaoglu, Jose Emilio Prieto, Vesselin Tonchev

Subject: Physical Sciences, Chemical Physics Keywords: n(t)-curves; modelling nucleation; Richards model, Model of Johnson-Mehl-Avrami-Kolmogorov; timescale of a phenomenon; cusp catastrophe

Online: 21 June 2023 (11:51:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1876.v1

Quantification of Analgesic and Anti-inflammatory Lipid Mediators in Long-Term Cryopreserved and Freeze-Dried Preserved Human Amniotic Membrane

Vladimír Vrkoslav, Ingrida Smeringaiova, Natalia Smorodinova, Alzbeta Svobodova, Stepan Strnad, Catherine Joan Jackson, Jan Burkert, Katerina Jirsova

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: amniotic membrane allografts; cryopreserved amniotic membrane; lyophilization; freeze-dried amniotic membrane; N-acylethanolamines; palmitoylethanolamide; tissue banking; mass spec-trometry

Online: 26 May 2023 (07:29:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0636.v1

Development of Blue Phosphorescent Pt(II) Materials using Dibenzofuranyl Imidazole Ligands and their Application in Organic Light-Emitting Diodes

Jun Yeob Lee, Youngjin Kang, Hakjo Kim, Dain Cho, Seung Chan Kim, Haein Kim

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: phosphorescent organic light-emitting diodes; heteroleptic Pt(II) complexes; C^N chelate; ancillary ligand; time-dependent density functional theory

Online: 9 May 2023 (10:25:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0147.v1

Fatigue Crack Initiation and Propagation Relation at Notched Specimens with Welded Joints Characteristics

Moritz Braun, Claas Fischer, Jörg Baumgartner, Matthias Hecht, Igor Varfolomeev

Subject: Engineering, Mechanical Engineering Keywords: notch fatigue analysis; finite element analysis; fracture mechanics; stress gradient; notch acuity; S-N curves; statistical methods; artificial notches

Online: 10 February 2022 (10:44:15 CET)

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Working Paper REVIEW

C,C- and C,N-Chelated Organocopper Compounds

Liang Liu, Hui Chen, Zhenqiang Yang, Junnian Wei, Zhenfeng Xi

Subject: Chemistry And Materials Science, Inorganic And Nuclear Chemistry Keywords: organocopper; C,N-chelated; C,C-chelated; bidentate; butadienyl; intramolecular coordination; three center-two electron bonds; structure-reactivity relationship

Online: 2 September 2021 (12:01:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201903.0166.v1

High Consistency of Structure-Based Design and X-Ray Crystallography: Design, Synthesis, Kinetic Evaluation and Crystallographic Binding Mode Determination of Biphenyl-N-Acyl-β-D-Glucopyranosylamines as Glycogen Phosphorylase Inhibitors

Thomas Fischer, Symeon M. Koulas, Anastasia S. Tsagkarakou, Efthimios Kyriakis, George A. Stravodimos, Vassiliki T. Skamnaki, Panagiota G.V. Liggri, Spyros E. Zographos, Rainer Riedl, Demetres D. Leonidas

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Structure-based design; glycogen phosphorylase inhibitor; glycogen metabolism; type 2 diabetes; X-ray crystallography; N-acyl-β-D-glucopyranosylamine

Online: 15 March 2019 (14:06:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0834.v1

BBPE-AE: A Byte Pair Encoding-Based Auto Encoder for Password Guessing

Samane Ghafari, Leila Safari, Mohsen Afsharchi

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Password Guessing; Cybersecurity; Password Strength Assessment; Autoencoder Network; Long Short-Term Memory (LSTM) Networks; Byte-level Byte Pair Encoding

Online: 11 September 2024 (10:49:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0881.v1

Texture Image Classification Using Wavelet Haar Approach and Gray Level Co-occurrence Matrix (GLCM)

Kiswanto Kiswanto, Hadiyanto Hadiyanto, Eko Sediyono

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: meat type texture image classification; image processing; wavelet haar; Gray level Cooccurrence Matrix (GLCM); K-Nearst Neighbor (K-NN)

Online: 15 April 2024 (11:30:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2208.v1

Integrating “Neoliberal-Turn” and “Social-Turn” Constructs in Examining Sustainable Development and Happiness and Life Satisfaction: A Global, Country Cluster, and Country Level Study

Arman Canatay, Leonel Prieto, Muhammad Ruhul Amin

Subject: Business, Economics And Management, Business And Management Keywords: Social turn models; Sustainable development pillars; Neoliberal turn constructs; Model configurations; Collaborative perspective; Global, cluster, and country-level analyses

Online: 31 May 2023 (09:01:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0570.v1

Adaptive Multi-Scale Fusion of Image Deblurring Networks for Drone and Aerial Remote Sensing Object Detection

Baoyu Zhu, Qunbo Lv, Zheng Tan

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: Drone and Aerial Remote Sensing; Image Deblurring; Generative Adversarial Networks; Multi-Scale; Image blur level; Object Detection; Deep Learning

Online: 30 December 2022 (04:45:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202206.0323.v1

A Novel Triple Radar Arrangement for Level 2 ADAS Detection System in Autonomous Vehicles

Javad Enayati, Pedram Asef, Yeshwanth Jonnalagadda

Subject: Engineering, Electrical And Electronic Engineering Keywords: Autonomous vehicles, triple radar, Level 2 ADAS system, lane keeping assistance, nonlinear model predictive controller, safety, autonomous emergency braking.

Online: 23 June 2022 (10:36:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0332.v1

Performance Assessment for Short-Term Water Demand Forecasting Models at an End-Use Level in Korea

Kang Min Koo, Kuk Heon Han, Kyung Soo Jun, Gyumin Lee, Jung Sik Kim, Kyung Taek Yum

Subject: Engineering, Automotive Engineering Keywords: smart water grid; advanced metering infrastructure; short-term water demand forecasting; end-use level; on-site sodium hypochlorite generator

Online: 13 April 2021 (09:20:08 CEST)

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It is crucial to forecast the water demand accurately for supplying water efficiently and stably in a water supply system. In particular, accurately forecasting short-term water demand helps in saving energy and reducing operating costs. With the introduction of the Smart Water Grid (SWG) in a water supply system, the amount of water consumption is obtained in real time through an advanced metering infrastructure (AMI) sensor, which can be used for forecasting the short-term water demand. The models widely used for water demand forecasting include the autoregressive integrated moving average, radial basis function-artificial neural network, quantitative multi-model predictor plus, and long short-term memory. However, there is a lack of research on assessing the performance of models and forecasting the short-term water demand by applying the data on the amount of water consumption by purpose and the pipe diameter of an end-use level of the SWG demonstration plant in each demand forecasting model. Therefore, in this study, the short-term water demand was forecasted for each model using the data collected from the AMI, and the performance of each model was assessed. The Smart Water Grid Research Group installed ultrasonic-wave-type AMI sensors in the block 112 located in YeongJong Island, Incheon, and the actual data used for operating the SWG demonstration plant were adopted. The performance of the model was assessed by using the residual, root mean square error (RMSE), normalized root mean square error (NRMSE), Nash–Sutcliffe efficiency (NSE), and Pearson correlation coefficient (PCC) as indices. The water demand forecast was slightly underestimated in models that employed the assessment results based on the RMSE and NRMSE. Furthermore, the forecasting accuracy was low for the NSE due to a large number of negative values; the correlation between the observed and forecasted values of the PCC was not high, and it was difficult to forecast the peak amount of water consumption. Therefore, as the short-term water demand forecasting models using only time and the amount of water consumption have limitations in reflecting the characteristics of consumers, a water supply system can be managed more precisely if other factors (weather, customer behavior, etc.) influencing the water demand are applied.

Preprint ARTICLE | doi:10.20944/preprints201909.0088.v1

Distributed Generation Planning in Active Distribution Networks Based on Multi-Scene Analysis

Sitong Lv, Jianguo Li, Yongxin Guo, Zhong Shi

Subject: Engineering, Electrical And Electronic Engineering Keywords: active distribution network; distributed generation; multi-scene analysis; Scene reduction; improved clustering algorithm; bi-level programming; comprehensive security index

Online: 8 September 2019 (16:28:28 CEST)

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