REVIEW
|
doi:10.20944/preprints201812.0273.v3
Subject:
Biology And Life Sciences,
Biophysics
Keywords:
mutations; disease-causing mutations; polymorphism; folding free energy change; binding free energy change; drug discovery; in silico screening
Online: 28 January 2019 (11:39:23 CET)
REVIEW
|
doi:10.20944/preprints201810.0577.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
myeloma; daratumumab; elotuzumab; isatuximab; CD38; JNJ- 63723283; denosumab; checkpoint inhibitors; BCMA; bispecific T-cell engager; antibody-drug conjugates
Online: 24 October 2018 (12:11:23 CEST)
ARTICLE
|
doi:10.20944/preprints201809.0513.v1
Subject:
Medicine And Pharmacology,
Tropical Medicine
Keywords:
Malawi, HIV, tuberculosis, anti-retroviral therapy, surveillance, patient monitoring, epidemic trends, drug supply, unique patient identifiers, data analysis
Online: 27 September 2018 (15:29:43 CEST)
REVIEW
|
doi:10.20944/preprints201807.0116.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
chemical space; chemoinformatics; data mining; databases; DNMT inhibitors; drug discovery; epi-informatics; molecular modeling; similarity searching; virtual screening
Online: 6 July 2018 (10:04:44 CEST)
REVIEW
|
doi:10.20944/preprints201802.0190.v1
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
Alzheimer’s disease; biomimetic nanocarriers; blood-brain barrier; dementia; drug targeting; lipid cubic phases; nanoemulsion; SR-BI; scavenger receptors
Online: 28 February 2018 (07:49:13 CET)
REVIEW
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
metabolic functionalization of alkyl moieties in drug molecules; structure influence on metabolic functionalization of alkyl moieties; mechanism of alkyl free radical hydroxy functionalization; pharmacologic activity of hydroxy and carboxy functionalized alkyl moieties in drug molecules; primary and auxiliary pharmacophores; auxophores
Online: 11 March 2020 (03:20:58 CET)
REVIEW
|
doi:10.20944/preprints202403.0181.v1
Subject:
Medicine And Pharmacology,
Complementary And Alternative Medicine
Keywords:
major depressive disorder; yoga; adjunctive treatment; hypothalamic-pituitary-adrenal axis; heart rate variability; interleukin-6; brain-derived neurotrophic factor
Online: 4 March 2024 (15:54:26 CET)
REVIEW
|
doi:10.20944/preprints202310.1240.v1
Subject:
Medicine And Pharmacology,
Surgery
Keywords:
review; chronic mesenteric ischemia; superior mesenteric artery; revascularization; treatment; endovascular revascularization (ER); percutaneous transluminal angioplasty (PTA); primary stenting (PMAS)
Online: 19 October 2023 (10:14:50 CEST)
REVIEW
|
doi:10.20944/preprints202306.2256.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
Helicobacter pylori; biofilms; planktonic; antibiotic resistance; extra polymeric substance; abiotic/biotic adhesion; dispersion; clinical treatment strategies; anti-biofilm strategies
Online: 30 June 2023 (12:41:48 CEST)
ARTICLE
|
doi:10.20944/preprints202306.0341.v1
Subject:
Medicine And Pharmacology,
Epidemiology And Infectious Diseases
Keywords:
tuberculosis infection; tuberculosis disease; tuberculosis preventive treatment; latent tuberculosis infection; diabetes mellitus; adverse events; isoniazid; rifampicin; randomized controlled trial
Online: 5 June 2023 (15:01:24 CEST)
REVIEW
|
doi:10.20944/preprints202110.0244.v1
Subject:
Environmental And Earth Sciences,
Environmental Science
Keywords:
peat; peat-based product; peat treatment; added-value products; environmentally friendly; homogeisation, pyrolysis; fulvic acid; humic acid; humic substances
Online: 18 October 2021 (11:46:20 CEST)
REVIEW
|
doi:10.20944/preprints202107.0353.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Lung cancer; Adjuvant treatment; Non-small-cell lung carcinoma (NSCLC); Epidermal growth factor receptor (EGFR); Tyrosine kinase inhibitor (TKI)
Online: 15 July 2021 (10:16:30 CEST)
ARTICLE
|
doi:10.20944/preprints202010.0189.v1
Subject:
Chemistry And Materials Science,
Analytical Chemistry
Keywords:
antioxidants for the treatment of ROS; new ester of eugenol; cosmetic formulations with clove water; skin penetration; Franz cell
Online: 9 October 2020 (08:59:05 CEST)
REVIEW
|
doi:10.20944/preprints202002.0427.v1
Subject:
Medicine And Pharmacology,
Clinical Medicine
Keywords:
adipose derived regenerative cells; ADRCs, efficacy; point of care treatment; randomized controlled trials; safety; stem cells; stromal vascular fraction
Online: 28 February 2020 (12:12:23 CET)
REVIEW
|
doi:10.20944/preprints201809.0434.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
colorectal cancer, cancer stem cells, mesenchymal stromal cells, stem cell markers, chemoresistance, treatment personalization, biomarkers, cancer stem cell markers
Online: 21 September 2018 (10:07:54 CEST)
HYPOTHESIS
|
doi:10.20944/preprints202407.1192.v1
Subject:
Medicine And Pharmacology,
Clinical Medicine
Keywords:
Homeostasis; Epigenetics; Epimutations; Hormesis; Toxicogenomics; Quantum biology; Superposition reference image, Ultra high dilutions. Quantum drug action.
Online: 16 July 2024 (00:14:47 CEST)
ARTICLE
|
doi:10.20944/preprints202406.0762.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
high-throughput screening; metabolic stability; ambient mass spectrometry; LA-REIMS; biomimetic metalloporphyrin; lead profiling; in vitro models; drug metabolism
Online: 12 June 2024 (14:15:32 CEST)
ARTICLE
|
doi:10.20944/preprints202406.0258.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
Parkinson-like events; Japanese Adverse Drug Event Report database; spontaneous reporting system; volcano plot; hierarchical clustering; principal component analysis
Online: 5 June 2024 (08:25:00 CEST)
ARTICLE
|
doi:10.20944/preprints202405.0084.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
natural extracts; chitosan; liposomes; encapsulation; drug release; coronavirus HCoV-0C43; antiviral activity; natural inhibitors of viral replication; cytotoxicity; phototoxicity
Online: 2 May 2024 (12:03:47 CEST)
REVIEW
|
doi:10.20944/preprints202402.1435.v1
Subject:
Medicine And Pharmacology,
Internal Medicine
Keywords:
secondary movement disorders; dystonia; chorea; athetosis; myoclonus; tics; tremor; drug-induced movement disorders; post-infectious movement disorders; metabolic disorders
Online: 26 February 2024 (11:45:00 CET)
ARTICLE
|
doi:10.20944/preprints202305.2131.v1
Subject:
Medicine And Pharmacology,
Ophthalmology
Keywords:
glaucoma; corticosteroids; intraocular pressure; Japanese Adverse Drug Event Report; spontaneous reporting system; volcano plot; hierarchical clustering; principal component analysis
Online: 30 May 2023 (11:43:13 CEST)
ARTICLE
|
doi:10.20944/preprints202305.0650.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
3D printing; hybrid scaffold; poly(caprolactone); chitosan; vancomycin; mesenchymal stem cells; tissue engineering; drug-delivery systems (DDSs); M osteomyelitis
Online: 9 May 2023 (12:05:37 CEST)
ARTICLE
|
doi:10.20944/preprints202304.1195.v1
Subject:
Medicine And Pharmacology,
Epidemiology And Infectious Diseases
Keywords:
COVID-19 pandemic; antimicrobial resistance; infectious diseases consultation; multi-drug resistant bacteria; infection prevention and control group; antibiotic stewardship
Online: 29 April 2023 (03:23:00 CEST)
ARTICLE
|
doi:10.20944/preprints202209.0417.v1
Subject:
Medicine And Pharmacology,
Cardiac And Cardiovascular Systems
Keywords:
Recreational substance abuse; drug abuse; marijuana; amphetamine; acute ischemic stroke; risk factors; young adult; NIS; Stroke; Sudden Cardiac Death
Online: 27 September 2022 (09:41:00 CEST)
REVIEW
|
doi:10.20944/preprints202108.0447.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
Interferons; IFNα; IFNß; IFNγ; antiviral; antiproliferative; immunomodulator; PEGylation; formulation; encapsulate IFNs; drug delivery system; liposomes; polymeric micelles; microparticles; nanoparticles
Online: 23 August 2021 (13:51:44 CEST)
REVIEW
|
doi:10.20944/preprints202101.0625.v1
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
Alzheimer’s disease; dementia, beta-amyloid; germ theory; drug development; clinical trials; herpes; spirochetes; Chlamydia pneumoniae; Porphyromonas gingivalis; toxoplasma; mycobacteria
Online: 29 January 2021 (13:57:18 CET)
REVIEW
|
doi:10.20944/preprints202012.0044.v1
Subject:
Biology And Life Sciences,
Anatomy And Physiology
Keywords:
Integrins; Tumor Microenvironment; Drug Resistance; Migration; Metastasis; Solid Tumors; The Cancer Genome Atlas; Gene Expression; Computational Biology; Therapeutic Targeting
Online: 1 December 2020 (18:26:11 CET)
ARTICLE
|
doi:10.20944/preprints202011.0474.v1
Subject:
Biology And Life Sciences,
Endocrinology And Metabolism
Keywords:
Breast cancer, genome-scale metabolic models, constraint-based analysis, divergence analysis, gene expression, metabolism, drug targets, personalized metabolic networks.
Online: 18 November 2020 (12:29:02 CET)
ARTICLE
|
doi:10.20944/preprints202011.0054.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
3D printing; semi-solid extrusion 3D printing; additive manufacturing; extemporaneous manufacturing; drug delivery; personalized dosage forms; veterinary medicine; prednisolone
Online: 2 November 2020 (14:59:30 CET)
REVIEW
|
doi:10.20944/preprints202010.0179.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Non Michaelis-Menten Kinetics; High-throughput screening; allostery; cooperativity; processive kinetics; distributive kinetics; single-molecule; auto-catalytic; drug discovery
Online: 8 October 2020 (13:34:16 CEST)
ARTICLE
|
doi:10.20944/preprints202005.0199.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
SARS-CoV-2; COVID-19; CADD; virtual screening; approved drugs; drug repurposing; essential targets; molecular docking; molecular dynamics simulations
Online: 11 May 2020 (13:14:18 CEST)
ARTICLE
|
doi:10.20944/preprints202004.0198.v1
Subject:
Medicine And Pharmacology,
Gastroenterology And Hepatology
Keywords:
mathematical modelling; peristalsis; smoothed particle hydrodynamics (SPH); fluid dynamics; large intestine; colonl proximal colon; fluid-structure interactions; drug delivery
Online: 12 April 2020 (15:57:17 CEST)
ARTICLE
|
doi:10.20944/preprints201811.0574.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
activity cliff; activity landscape plotter; epigenetics; docking; drug discovery; D-tools; molecular dynamics; Epi-polypharmacology; SmART; structure-activity relationships
Online: 26 November 2018 (07:14:05 CET)
ARTICLE
|
doi:10.20944/preprints202407.1457.v1
Subject:
Waste Management And Disposal,
Environmental And Earth Sciences
Keywords:
Decarbonization; carbon footprint; digital technology; data automation; decision support systems; environmental management; solid waste management; wastewater treatment; contaminated soil remediation,
Online: 18 July 2024 (09:55:16 CEST)
ARTICLE
|
doi:10.20944/preprints202407.0230.v1
Subject:
Medicine And Pharmacology,
Gastroenterology And Hepatology
Keywords:
Esophageal-Adenocarcinoma; Cancer; immunotherapy; treatment; single-cell RNA; single-cell sequencing; RNA sequencing; transcriptional signature; response to therapy; immune infiltrate.
Online: 3 July 2024 (00:25:13 CEST)
ARTICLE
|
doi:10.20944/preprints202405.0845.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Small-cell lung cancer; Relapsed small-cell lung cancer; extensive-stage small-cell lung cancer; Paclitaxel; Gemcitabine; second-line treatment.
Online: 13 May 2024 (13:29:44 CEST)
ARTICLE
|
doi:10.20944/preprints202402.0366.v1
Subject:
Social Sciences,
Education
Keywords:
Sports nutrition knowledge; Treatment self-regulation questionnaire; Brief-type self-administered diet history questionnaire; Intervention study; Nutrition education; Male Athletes
Online: 6 February 2024 (13:06:02 CET)
REVIEW
|
doi:10.20944/preprints202401.2158.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Dystrophin; mitochondria; inflammation; reactive oxygen species; glucocorticoids; cardiomyopathy; neuromuscular disease; therapeutic target; treatment; stress response; ATP; respiration; calcium; ion homeostasis
Online: 31 January 2024 (07:21:25 CET)
REVIEW
|
doi:10.20944/preprints202401.1989.v1
Subject:
Biology And Life Sciences,
Life Sciences
Keywords:
cancer; cancer treatment; cancer treatments history; cancer therapy; oncology; immunology; chemotherapy; radiation therapy; ADC; CART; BiTE; targeted therapy; cancer genetics
Online: 30 January 2024 (03:28:49 CET)
ARTICLE
|
doi:10.20944/preprints202401.1823.v1
Subject:
Engineering,
Metallurgy And Metallurgical Engineering
Keywords:
Al-Cu-Li-Mg-Zr alloys; Sc addition; twin-roll casting; constrained groove pressing; solution treatment; aging; pre-deformation; precipitation
Online: 25 January 2024 (10:12:16 CET)
REVIEW
|
doi:10.20944/preprints202401.0800.v1
Subject:
Medicine And Pharmacology,
Dermatology
Keywords:
psoriasis; oral therapies; topical therapies; biologics; Jak inhibitors; PDE4 inhibitors; systemic treatment; IL-17 inhibitors; IL-23 inhibitors; tapinarof; roflumilast
Online: 10 January 2024 (08:49:06 CET)
REVIEW
|
doi:10.20944/preprints202310.0637.v1
Subject:
Medicine And Pharmacology,
Clinical Medicine
Keywords:
Myalgic Encephalomyelitis; chronic fatigue syndrome; therapeutic strategies; personalized treatment; pathophysiology; pharmacological treatments; nutritional supplements; dietary changes; physical therapies; lifestyle modifications
Online: 10 October 2023 (11:23:01 CEST)
REVIEW
|
doi:10.20944/preprints202305.0720.v2
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Prostate cancer; androgen receptor; AR signaling pathway; disease progression; therapeutic re-sistance; personalized treatment; androgen deprivation therapy; AR-targeted therapies
Online: 25 September 2023 (16:46:10 CEST)
REVIEW
|
doi:10.20944/preprints202309.0860.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
gastrointestinal cancer; immunotherapy; cancer vaccines; dendritic cell vaccine; adoptive cell treatment; cytokine-induced killer cells; immune checkpoint inhibitors; angiogenesis inhibition
Online: 13 September 2023 (10:07:21 CEST)
REVIEW
|
doi:10.20944/preprints202308.0806.v1
Subject:
Public Health And Healthcare,
Other
Keywords:
Hyperglycemic Hyperosmolar State (HHS); Diabetic Ketoacidosis (DKA); Hyperglycemia; Mixed HHS and DKA; Treatment protocols, Prognosis; Electrolyte imbalances; Patient management strategies
Online: 10 August 2023 (08:21:45 CEST)
ARTICLE
|
doi:10.20944/preprints202306.0393.v1
Subject:
Environmental And Earth Sciences,
Water Science And Technology
Keywords:
MBBR-MBR; biofilm; 3D-printed biocarriers; Kaldnes K1 biocarriers; 13X-halloysite biocarriers; membrane fouling; SMP; EPS; colloidal particles; wastewater treatment
Online: 6 June 2023 (07:14:22 CEST)
ARTICLE
|
doi:10.20944/preprints202209.0359.v1
Subject:
Computer Science And Mathematics,
Applied Mathematics
Keywords:
Hematological malignancies; treatment outcomes; CAR-T cell exhaustion; memory 22 pool, functional CAR-T cells; antigen dependent CAR-T expansion
Online: 23 September 2022 (05:33:24 CEST)
ARTICLE
|
doi:10.20944/preprints202209.0346.v1
Subject:
Medicine And Pharmacology,
Gastroenterology And Hepatology
Keywords:
gastrointestinal cramps; gastrointestinal pain; irritable bowel syndrome; hyoscine butyl bromide; peppermint oil; over-the-counter treatment; pharmacy-based patient survey
Online: 22 September 2022 (14:15:32 CEST)
REVIEW
|
doi:10.20944/preprints202209.0162.v1
Subject:
Chemistry And Materials Science,
Surfaces, Coatings And Films
Keywords:
Bi-substituted; RF magnetron; Sputtering; Annealing; Oxygen plasma treatment; Magneto-optic; Faraday rotation; Figure of merit; Hysteresis loop; Imaging; Sensing.
Online: 13 September 2022 (05:53:32 CEST)
HYPOTHESIS
|
doi:10.20944/preprints202002.0147.v4
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
Coronavirus; SARS-CoV-2; COVID-19; interferon; IFN; superinfection therapy; SIT; infectious bursal disease virus; IBDV; R903/78; safety; treatment
Online: 1 February 2021 (16:07:55 CET)
REVIEW
|
doi:10.20944/preprints202011.0334.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
antiplatelet; aspirin; clopidogrel; ischemic stroke; TIA; platelet function analysis; antiplatelet therapy modification; secondary stroke prevention; high on-treatment platelet reactivity
Online: 12 November 2020 (09:35:12 CET)
REVIEW
|
doi:10.20944/preprints202009.0534.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
breast cancer etiopathogenesis; breast cancer treatment; hydrogen ion dynamics of cancer; pH-related paradigm; H+-related therapeutics of breast cancer
Online: 23 September 2020 (04:04:24 CEST)
REVIEW
|
doi:10.20944/preprints201908.0274.v1
Subject:
Biology And Life Sciences,
Anatomy And Physiology
Keywords:
electricity; tumor treating fields; extremely low frequency; pulsed electric fields; new cancer treatment modalities; glioblastoma; electroporation; electrofusion; electrochemotherapy; gene electrotransference
Online: 26 August 2019 (16:04:26 CEST)
ARTICLE
|
doi:10.20944/preprints202407.0891.v1
Subject:
Chemistry And Materials Science,
Nanotechnology
Keywords:
multi-drug-resistant bacteria; triphenyl phosphonium salts; mitochondria target bola-amphiphiles; membranes permeabilization; MICs determination; time-killing experiments; cytotoxicity studies
Online: 11 July 2024 (11:27:17 CEST)
ARTICLE
|
doi:10.20944/preprints202405.0360.v1
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
Traumatic brain injury; TBI; secondary injury; peptide therapeutics; cell penetrating peptide; pro-inflammatory cytokines; intranasal drug delivery; blood brain barrier
Online: 7 May 2024 (11:13:30 CEST)
ARTICLE
|
doi:10.20944/preprints202404.0875.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
humidity variation; temperature variation; X-ray crystallography; peptides; polymorphism; octreotide; drug stability; in situ X-ray powder diffraction
Online: 15 April 2024 (11:34:32 CEST)
ARTICLE
|
doi:10.20944/preprints202403.0045.v1
Subject:
Chemistry And Materials Science,
Biomaterials
Keywords:
heterograft copolymer; hydrogel; alginate; thermo-responsive; pH-responsive; poly(2- vinyl pyridine)-b-polyethylene oxide; diblock copolymer micelles; drug delivery
Online: 1 March 2024 (12:03:46 CET)
ARTICLE
|
doi:10.20944/preprints202312.1519.v1
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
Durysta, Bimatoprost; Ciliary Sulcus, Middle Space Operations; MiSO; Middle Space Therapeutics; MiST; ArcScan; Ultrasound; Depot; Drug Delivery; Posterior Chamber; Sulcus
Online: 20 December 2023 (09:09:38 CET)
REVIEW
|
doi:10.20944/preprints202312.1173.v1
Subject:
Biology And Life Sciences,
Neuroscience And Neurology
Keywords:
Alzheimer’s disease; transgenic animal model; amyloidogenesis; amyloid-beta; peptide; isoaspartate; zinc; α4β2 nicotinic acetylcholine receptor; aggregation seeding; anti-amyloid drug
Online: 15 December 2023 (12:23:06 CET)
REVIEW
|
doi:10.20944/preprints202312.0387.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
big data; not-so-big data; molecular design; drug design; machine learning; artificial intelligence; descriptor; computer-generated descriptors; property; regression
Online: 6 December 2023 (10:19:02 CET)
ARTICLE
|
doi:10.20944/preprints202308.1493.v1
Subject:
Medicine And Pharmacology,
Pharmacy
Keywords:
silver nanoparticles; chlorhexidine; conjunction; complexation; surface functionalization; nano-scaled drug delivery; antimicrobial synergism; antiviral activity; Camellia sinensis catechins; green synthesis
Online: 22 August 2023 (09:52:09 CEST)
REVIEW
|
doi:10.20944/preprints202308.1518.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
SARS-CoV-2; main protease; inhibitors; molecular modeling; molecular dynamics simulations; binding energy calculation; ADME properties; potential therapeutics; drug discovery
Online: 22 August 2023 (07:19:37 CEST)
ARTICLE
|
doi:10.20944/preprints202305.1605.v1
Subject:
Medicine And Pharmacology,
Pharmacy
Keywords:
pH sensitive Polymer; Methacrylate Polymers; Eudragit L100; Polymeric nanoparticles; Apocynin; Rheumatoid arthritis; Carbopol-934 based Hydrogel; Transdermal Drug Delivery System
Online: 23 May 2023 (07:51:12 CEST)
ARTICLE
|
doi:10.20944/preprints202305.1334.v1
Subject:
Public Health And Healthcare,
Public Health And Health Services
Keywords:
victimizing and perpetrating violence; interpersonal and intimate violence; harmful alcohol and drug use; mental health symptoms; paths of violence; gender
Online: 18 May 2023 (10:46:13 CEST)
REVIEW
|
doi:10.20944/preprints202305.0034.v1
Subject:
Biology And Life Sciences,
Cell And Developmental Biology
Keywords:
organ-on-a-chip; gut-on-a-chip; intestine; in vitro; ex vivo; ADME; oral bioavailability; drug development; microbiome; IBD
Online: 2 May 2023 (01:15:08 CEST)
REVIEW
|
doi:10.20944/preprints202303.0464.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
Therapeutic proteins; Recombinant proteins; Repurposing; Reinventing, Drug-antibody combinations, AI/ML, Efficacy improvement, Immunogenicity; Artificial Intelligence; mRNA; High throughput analysis
Online: 27 March 2023 (14:02:03 CEST)
ARTICLE
|
doi:10.20944/preprints202303.0192.v1
Subject:
Biology And Life Sciences,
Anatomy And Physiology
Keywords:
Phenome; Matrisome; Matreotype; Phenotype; Extracellular Matrix; Data Mining; SNP; PheWAS; GWAS; Electronic Health Records; Drug Repurposing; Precision Medicine; Collagen; Human
Online: 10 March 2023 (09:34:15 CET)
REVIEW
Subject:
Biology And Life Sciences,
Virology
Keywords:
Chikungunya virus; alphavirus; antiviral therapy; direct-acting antivirals; host-directed antivirals; in silico screening; in vivo validation; antiviral drug development
Online: 10 June 2021 (09:15:45 CEST)
ARTICLE
|
doi:10.20944/preprints202101.0478.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
ocular drug delivery system; topical liposomes; posterior segment of the eye; safety and toler-ability; biologic activity; diabetic macular edema
Online: 25 January 2021 (10:48:51 CET)
REVIEW
|
doi:10.20944/preprints202007.0016.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
myeloma; BCMA; bispecific T-cell engager; antibody-drug conjugates; chimeric antigen receptor T-cells; belantamab mafodotin; idecabtagene vicleucel; JNJ-68284528
Online: 3 July 2020 (07:30:57 CEST)
REVIEW
|
doi:10.20944/preprints201812.0170.v1
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
bacterial nanocellulose; nanofibrillated nanocellulose; animal nanocellulose; algal nanocellulose; tissue engineering; tissue repair; wound dressing; cell delivery; drug delivery; antimicrobial properties
Online: 14 December 2018 (06:44:53 CET)
REVIEW
|
doi:10.20944/preprints201810.0204.v2
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
DNA origami; aptamer; DNA nanotechnology; protein nano array; biosensor; logic gate; enzyme cascade; drug delivery system; targeted therapy; molecular robotics
Online: 22 October 2018 (10:57:21 CEST)
ARTICLE
|
doi:10.20944/preprints202403.1554.v1
Subject:
Computer Science And Mathematics,
Probability And Statistics
Keywords:
censoring; copula; Hand’s paradox; potential outcome; Mann-Whitney effect; stress-strength model; two-sample comparison; survival analysis; survival function; treatment effect
Online: 26 March 2024 (09:41:01 CET)
ARTICLE
|
doi:10.20944/preprints202401.0100.v1
Subject:
Medicine And Pharmacology,
Epidemiology And Infectious Diseases
Keywords:
dolutegravir/lamivudine (DTG/3TC); bictegravir/emtricitabine/tenofovir alafenamide fumarate (BIC/FTC/TAF); effectiveness; treatment-experienced adults living with HIV; real-world
Online: 3 January 2024 (10:25:58 CET)
ARTICLE
|
doi:10.20944/preprints202312.1092.v1
Subject:
Public Health And Healthcare,
Health Policy And Services
Keywords:
Orthodontic risk communication; informed consent; patient-centered care; cross-cultural practices; treatment risks; orthodontist perspectives; digital tools; patient satisfaction; ethical considerations
Online: 14 December 2023 (11:04:20 CET)
COMMUNICATION
|
doi:10.20944/preprints202312.0651.v2
Subject:
Medicine And Pharmacology,
Hematology
Keywords:
alternative leukemia treatment; antileukemic agents; antimicrobial peptide; dual-activity compounds; bioconjugates; cell penetration peptide; ciprofloxacin; hematopoietic stem cell transplantation; levofloxacin; lactoferricin B; fluconazole; fluoroquinolones.
Online: 29 January 2024 (08:40:14 CET)
REVIEW
|
doi:10.20944/preprints202309.0453.v1
Subject:
Medicine And Pharmacology,
Dentistry And Oral Surgery
Keywords:
platelet-rich fibrin; ridge augmentation; socket augmentation; grafting; cytokines; growth factors; tissue regeneration; bio-enhancement; PRF; platelet concentrate; accelerated implant treatment
Online: 7 September 2023 (09:27:09 CEST)
REVIEW
|
doi:10.20944/preprints202306.1884.v1
Subject:
Public Health And Healthcare,
Physical Therapy, Sports Therapy And Rehabilitation
Keywords:
Stretching; static stretching (SS); joint range of motion (ROM); muscle stiffness; joint-ligament-tendon-muscle unit; joint injuries - treatment and prophylaxis
Online: 27 June 2023 (10:31:19 CEST)
ARTICLE
|
doi:10.20944/preprints202304.1052.v1
Subject:
Physical Sciences,
Optics And Photonics
Keywords:
LIDT; Laser-Induced Damage Threshold; 3D Micro-optics; Laser Direct Writing; Multi-Photon Lithography; SZ2080™; Calcination; Thermal Treatment; Polymers; Glass
Online: 27 April 2023 (07:08:06 CEST)
ARTICLE
|
doi:10.20944/preprints202304.0950.v1
Subject:
Medicine And Pharmacology,
Dietetics And Nutrition
Keywords:
fasting; caloric restriction; osteoarthritis; dietary intervention; fasting-mimicking diet; integrative medicine; complementary medicine; Traditional European Medicine; nutrition; multimodal in-tegrative treatment
Online: 26 April 2023 (03:52:40 CEST)
REVIEW
|
doi:10.20944/preprints202104.0272.v1
Subject:
Chemistry And Materials Science,
Biomaterials
Keywords:
carbon materials synthesis and functionalization; energy; graphene; gas separation; hydrothermal and solvothermal carbonization; microwave-assisted synthesis; nanocomposite membranes; sensing; water treatment
Online: 12 April 2021 (09:32:49 CEST)
REVIEW
|
doi:10.20944/preprints202405.1223.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
antipsychotic drug; M4 and M1 receptor agonist; negative schizophrenia symptoms; neural network; schizophrenia; trace-amine-associated receptor 1 agonist; ulataront; xanomeline
Online: 20 May 2024 (12:31:08 CEST)
REVIEW
|
doi:10.20944/preprints202307.2136.v1
Subject:
Public Health And Healthcare,
Public Health And Health Services
Keywords:
Epilepsy; Pediatric Drug Development (PDD); Therapeutic Orphans; Extrapolation of efficacy from adults to children; Antiseizure Medications (ASMs); Pediatric Investigation Plan (PIP)
Online: 1 August 2023 (02:49:45 CEST)
ARTICLE
|
doi:10.20944/preprints202307.0133.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
Hydrophilic polymers; Thermo-responsive polymers; Polymer drug delivery system; Tumor-specific targeting; Recombinant proteins; Non-covalent attachment; Tris(nitrilotriacetic acid) ligation
Online: 4 July 2023 (08:01:27 CEST)
ARTICLE
|
doi:10.20944/preprints202303.0322.v1
Subject:
Computer Science And Mathematics,
Computer Science
Keywords:
Hemolytic peptide; Network science; Half-Space Proximal Networks; Metadata Networks; Visual mining; Cluster analysis; Motif discovery; StarPep toolbox; Peptide drug discovery
Online: 17 March 2023 (10:05:05 CET)
ARTICLE
|
doi:10.20944/preprints202206.0177.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Deuterium-depleted water (DDW); deuterium-depleted organic compounds (DDOC); anticancer drug development; D/H ratio; production of metabolic water; ketogenic diet
Online: 13 June 2022 (09:49:32 CEST)
REVIEW
|
doi:10.20944/preprints202205.0037.v1
Subject:
Medicine And Pharmacology,
Dermatology
Keywords:
Melanoma; Chemo-thermo-immuno-therapy; Melanogenesis; Magnetite nanoparticle; Drug delivery system; Heat shock protein; In situ vaccine therapy; Immune checkpoint inhibitor
Online: 5 May 2022 (12:23:27 CEST)
ARTICLE
Subject:
Chemistry And Materials Science,
Nanotechnology
Keywords:
Sepiapterin; triacetyl-β-cyclodextrin (TAβCD); hydrophilic drug/cyclodextrin complexes; spray-drying; methoxy-poly(ethylene-glycol)-poly(epsilon-caprolactone) (mPEG-PCL) nanoparticles
Online: 24 May 2019 (11:42:42 CEST)
REVIEW
|
doi:10.20944/preprints201805.0426.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
biological activity; crosslinking; drug delivery; cosmetic; food-supplement; functionalization; hyaluronan applications; hyaluronan derivatives; hyaluronan synthases; hyaluronic acid; hyaluronidases; physico-chemical properties
Online: 29 May 2018 (12:13:48 CEST)
ARTICLE
|
doi:10.20944/preprints201804.0245.v1
Subject:
Chemistry And Materials Science,
Polymers And Plastics
Keywords:
Chitosan-g-PMMA amphiphilic nanoparticles; thiolated polymers; mucoadhesion; mucosal drug delivery; Caco2 and HT29-MTX cell lines; apparent permeability in vitro.
Online: 18 April 2018 (16:28:21 CEST)
ARTICLE
|
doi:10.20944/preprints202406.0030.v1
Subject:
Biology And Life Sciences,
Plant Sciences
Keywords:
world rice (Oryza sativa L.) core collection; seed longevity; embryonic RNA stability; RNA integrity number (RIN); controlled deterioration treatment (CDT); breeding materials
Online: 4 June 2024 (02:52:33 CEST)
REVIEW
|
doi:10.20944/preprints202403.0357.v1
Subject:
Medicine And Pharmacology,
Orthopedics And Sports Medicine
Keywords:
Exertional Compartment Syndrome, Compartment Syndrome, Sports, Exercise, Injury, Protocol, Preventative Measures, Diagnosis, Treatment, Anatomy, Physiology, Corrective Strength Training, Physical Therapy
Online: 6 March 2024 (13:03:45 CET)
ARTICLE
|
doi:10.20944/preprints202009.0532.v2
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
adipose derived regenerative cells; ADRCs; efficacy; point of care treatment; stem cells; stromal vascular fraction; tendon healing without scar formation; tendon regeneration
Online: 28 June 2021 (15:47:12 CEST)
ARTICLE
Subject:
Biology And Life Sciences,
Biophysics
Keywords:
consciousness 1; subjective experience 2; will 3; agency 4; self 5; psychopathology 6; treatment 7; transcranial near infrared light 8; biophotomodulation 9
Online: 25 May 2021 (08:44:47 CEST)
ARTICLE
|
doi:10.20944/preprints201608.0232.v2
Subject:
Medicine And Pharmacology,
Pulmonary And Respiratory Medicine
Keywords:
mHealth; ODK scan; mobile health application; digitizing data collection; data management processes; paper-to-digital system; technology-assisted data management; treatment adherence
Online: 2 September 2016 (03:17:38 CEST)
REVIEW
|
doi:10.20944/preprints202401.0676.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
HER2; breast cancer; breast neoplasms; antibody-drug conjugate; ADCs; trastuzumab emtansine; trastuzumab deruxtecan; disitamab Vedotin; ARX-788; SYD985; BL-M0701; zanidatamab zovodotin.
Online: 9 January 2024 (10:29:59 CET)
REVIEW
|
doi:10.20944/preprints202312.1480.v1
Subject:
Chemistry And Materials Science,
Nanotechnology
Keywords:
Nano-drugs; Nanoparticle; Delivery System; Vaccine; Liposome; Exosome; Stealth Effect; SLN; Inclusion and Dispersion Systems; Solid State Reactive Mixing; Nanosome; Drug Carrier
Online: 20 December 2023 (10:54:31 CET)
REVIEW
|
doi:10.20944/preprints202307.1284.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Cancer; tumourigenesis; drug resistance; signalling pathways; Wnt/β-catenin pathway; JAK/STAT pathway; PI3K/Akt/mTOR pathway; RAS/RAF/MAPK/ERK signalling
Online: 19 July 2023 (09:14:02 CEST)
ARTICLE
|
doi:10.20944/preprints202306.1818.v1
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
Alternative Splicing; two-colour (GFP/RFP) Fluorescent Reporter; MAPT; Exon-Skipping; FTDP-17; High Content Screening; siRNA; Nucleic Acids Therapeutics; Drug discovery
Online: 26 June 2023 (13:55:26 CEST)
ARTICLE
|
doi:10.20944/preprints202202.0194.v1
Subject:
Medicine And Pharmacology,
Pulmonary And Respiratory Medicine
Keywords:
antifungal resistance; isavuconazole; cystic fibrosis; pulmonary disease; Aspergillus fumigatus; pulmonary aspergillosis; respiratory disease; antifungal stewardship; therapeutic drug monitoring; minimum inhibitory concentration (MIC)
Online: 16 February 2022 (05:12:39 CET)