REVIEW
|
doi:10.20944/preprints202312.1173.v1
Subject:
Biology And Life Sciences,
Neuroscience And Neurology
Keywords:
Alzheimer’s disease; transgenic animal model; amyloidogenesis; amyloid-beta; peptide; isoaspartate; zinc; α4β2 nicotinic acetylcholine receptor; aggregation seeding; anti-amyloid drug
Online: 15 December 2023 (12:23:06 CET)
REVIEW
|
doi:10.20944/preprints202312.0387.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
big data; not-so-big data; molecular design; drug design; machine learning; artificial intelligence; descriptor; computer-generated descriptors; property; regression
Online: 6 December 2023 (10:19:02 CET)
ARTICLE
|
doi:10.20944/preprints202308.1493.v1
Subject:
Medicine And Pharmacology,
Pharmacy
Keywords:
silver nanoparticles; chlorhexidine; conjunction; complexation; surface functionalization; nano-scaled drug delivery; antimicrobial synergism; antiviral activity; Camellia sinensis catechins; green synthesis
Online: 22 August 2023 (09:52:09 CEST)
REVIEW
|
doi:10.20944/preprints202308.1518.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
SARS-CoV-2; main protease; inhibitors; molecular modeling; molecular dynamics simulations; binding energy calculation; ADME properties; potential therapeutics; drug discovery
Online: 22 August 2023 (07:19:37 CEST)
ARTICLE
|
doi:10.20944/preprints202305.1605.v1
Subject:
Medicine And Pharmacology,
Pharmacy
Keywords:
pH sensitive Polymer; Methacrylate Polymers; Eudragit L100; Polymeric nanoparticles; Apocynin; Rheumatoid arthritis; Carbopol-934 based Hydrogel; Transdermal Drug Delivery System
Online: 23 May 2023 (07:51:12 CEST)
ARTICLE
|
doi:10.20944/preprints202305.1334.v1
Subject:
Public Health And Healthcare,
Public Health And Health Services
Keywords:
victimizing and perpetrating violence; interpersonal and intimate violence; harmful alcohol and drug use; mental health symptoms; paths of violence; gender
Online: 18 May 2023 (10:46:13 CEST)
REVIEW
|
doi:10.20944/preprints202305.0034.v1
Subject:
Biology And Life Sciences,
Cell And Developmental Biology
Keywords:
organ-on-a-chip; gut-on-a-chip; intestine; in vitro; ex vivo; ADME; oral bioavailability; drug development; microbiome; IBD
Online: 2 May 2023 (01:15:08 CEST)
REVIEW
|
doi:10.20944/preprints202303.0464.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
Therapeutic proteins; Recombinant proteins; Repurposing; Reinventing, Drug-antibody combinations, AI/ML, Efficacy improvement, Immunogenicity; Artificial Intelligence; mRNA; High throughput analysis
Online: 27 March 2023 (14:02:03 CEST)
ARTICLE
|
doi:10.20944/preprints202303.0192.v1
Subject:
Biology And Life Sciences,
Anatomy And Physiology
Keywords:
Phenome; Matrisome; Matreotype; Phenotype; Extracellular Matrix; Data Mining; SNP; PheWAS; GWAS; Electronic Health Records; Drug Repurposing; Precision Medicine; Collagen; Human
Online: 10 March 2023 (09:34:15 CET)
REVIEW
Subject:
Biology And Life Sciences,
Virology
Keywords:
Chikungunya virus; alphavirus; antiviral therapy; direct-acting antivirals; host-directed antivirals; in silico screening; in vivo validation; antiviral drug development
Online: 10 June 2021 (09:15:45 CEST)
ARTICLE
|
doi:10.20944/preprints202101.0478.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
ocular drug delivery system; topical liposomes; posterior segment of the eye; safety and toler-ability; biologic activity; diabetic macular edema
Online: 25 January 2021 (10:48:51 CET)
REVIEW
|
doi:10.20944/preprints202007.0016.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
myeloma; BCMA; bispecific T-cell engager; antibody-drug conjugates; chimeric antigen receptor T-cells; belantamab mafodotin; idecabtagene vicleucel; JNJ-68284528
Online: 3 July 2020 (07:30:57 CEST)
REVIEW
|
doi:10.20944/preprints201812.0170.v1
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
bacterial nanocellulose; nanofibrillated nanocellulose; animal nanocellulose; algal nanocellulose; tissue engineering; tissue repair; wound dressing; cell delivery; drug delivery; antimicrobial properties
Online: 14 December 2018 (06:44:53 CET)
REVIEW
|
doi:10.20944/preprints201810.0204.v2
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
DNA origami; aptamer; DNA nanotechnology; protein nano array; biosensor; logic gate; enzyme cascade; drug delivery system; targeted therapy; molecular robotics
Online: 22 October 2018 (10:57:21 CEST)
ARTICLE
|
doi:10.20944/preprints202405.1543.v1
Subject:
Chemistry And Materials Science,
Chemical Engineering
Keywords:
Poly(vinyl alcohol) (PVA); Vinyltriethoxysilane Functionalized Graphene Oxide (VTESFGO); Nanocomposite Films (NCFs); Oxygen Transmission Rate (OTR); Water Resistance Pressure
Online: 23 May 2024 (12:52:34 CEST)
REVIEW
|
doi:10.20944/preprints202312.2132.v1
Subject:
Biology And Life Sciences,
Agricultural Science And Agronomy
Keywords:
Colletotrichum lupini; Lupinus spp; disease management; early molecular pathogen detection; infection mechanisms; molecular regulatory pathways; prophylaxis; genetic resistance; breeding
Online: 28 December 2023 (10:17:45 CET)
REVIEW
|
doi:10.20944/preprints202311.0237.v1
Subject:
Medicine And Pharmacology,
Anatomy And Physiology
Keywords:
Type 2 diabetes mellitus; Prediabetes; skeletal muscle; satellite cells; myogenic regulatory factors, insulin resistance; muscle fibers; inflammation; oxidative stress
Online: 3 November 2023 (10:25:51 CET)
REVIEW
|
doi:10.20944/preprints202310.0910.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
immune checkpoint inhibitor; resistance mechanism; melanoma; oral mucosal melanoma; immunotherapy; immune checkpoint blockade; anti-PD-1; anti-CTLA-4
Online: 17 October 2023 (03:37:34 CEST)
REVIEW
|
doi:10.20944/preprints202310.0576.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
methylglyoxal; glyoxalase; advanced glycation end products; MG-H1, metabolic syndrome; insulin resistance, diabetes mellitus; cardiovascular disease; metformin; methylglyoxal scavengers
Online: 10 October 2023 (12:31:23 CEST)
ARTICLE
|
doi:10.20944/preprints202309.1726.v1
Subject:
Biology And Life Sciences,
Agricultural Science And Agronomy
Keywords:
barley; Blumeria graminis f. sp. hordei; Hordeum vulgare; reverse octal notation; powdery mildew; resistance genes; virulence complexity; virulence frequency
Online: 26 September 2023 (04:01:50 CEST)
ARTICLE
|
doi:10.20944/preprints202307.1235.v1
Subject:
Public Health And Healthcare,
Primary Health Care
Keywords:
antimicrobial resistance; antibiotics; antibiotic use; misconceptions and knowledge gaps; general practice; out-of-hours services; nursing homes; community pharmacies
Online: 18 July 2023 (12:23:26 CEST)
REVIEW
|
doi:10.20944/preprints202306.2256.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
Helicobacter pylori; biofilms; planktonic; antibiotic resistance; extra polymeric substance; abiotic/biotic adhesion; dispersion; clinical treatment strategies; anti-biofilm strategies
Online: 30 June 2023 (12:41:48 CEST)
ARTICLE
|
doi:10.20944/preprints202209.0326.v1
Subject:
Medicine And Pharmacology,
Clinical Medicine
Keywords:
multidrug resistance organism; sepsis; adequate empirical antibiotics; source of infection; APACHE II; ICU length stay; predictors; risk factors; mortality
Online: 21 September 2022 (10:45:23 CEST)
ARTICLE
|
doi:10.20944/preprints202208.0171.v2
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
combination; antimicrobial resistance; selection index; collateral sensitivity; mutant prevention concentration; minimal inhibitory concentration; fractional inhibitory concentration index; stress factor
Online: 13 September 2022 (07:53:32 CEST)
ARTICLE
|
doi:10.20944/preprints202012.0747.v1
Subject:
Engineering,
Automotive Engineering
Keywords:
alkali activated; fly ash; blast furnace slag; silica fume; metakaolin; ambient curing; strength development; flexural strength; freeze-thaw resistance
Online: 30 December 2020 (09:03:09 CET)
ARTICLE
|
doi:10.20944/preprints202012.0582.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
Liquid-based 3D culture; tumoroid; cisplatin resistance; imatinib (gleevec); tyrosine kinase inhibitor (TKI); organoid; spheroid; metastatic colorectal cancer (mCRC)
Online: 23 December 2020 (10:15:46 CET)
REVIEW
Subject:
Biology And Life Sciences,
Cell And Developmental Biology
Keywords:
stress granules; G3BP1; G3BP2; Caprin-1; USP10; TIA1; TIAR; cancer prognosis; biomarker; metastasis; resistance; cell death; pro-survival properties
Online: 7 April 2020 (01:56:12 CEST)
ARTICLE
|
doi:10.20944/preprints202002.0110.v1
Subject:
Biology And Life Sciences,
Plant Sciences
Keywords:
invasion ecology; biotic resistance; exotic plants; heterospecific pollen; reproductive interference; alien plants; indirect plant-plant interactions; Darwin's naturalization hypothesis
Online: 9 February 2020 (16:32:53 CET)
ARTICLE
|
doi:10.20944/preprints201811.0336.v1
Subject:
Biology And Life Sciences,
Plant Sciences
Keywords:
pasmo resistance, pasmo severity, quantitative trait loci (QTL), quantitative trait nucleotides (QTNs), fiber, linseed, core collection, flax, Linum usitatissimum
Online: 14 November 2018 (10:45:20 CET)
ARTICLE
|
doi:10.20944/preprints201810.0042.v1
Subject:
Engineering,
Mechanical Engineering
Keywords:
Turbulent flow; Laminar flow; Pipes; Friction factor; Hydraulics; Monotonic roughness, Inflectional roughness; Smooth curve contact; Moody diagram; Hydraulic resistance.
Online: 3 October 2018 (11:38:49 CEST)
ARTICLE
|
doi:10.20944/preprints201703.0015.v1
Subject:
Physical Sciences,
Fluids And Plasmas Physics
Keywords:
colebrook equation; colebrook-white; moody diagram; turbulent flow; hydraulic resistance; darcy friction; pipes; genetic algorithms; optimization techniques; error analysis
Online: 2 March 2017 (07:57:54 CET)
ARTICLE
|
doi:10.20944/preprints202407.1672.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
immune imbalance; Immune Imbalance Transcriptomics; IIT; B-cell lymphoma; Systemic Lupus Erythematosus (SLE); RNA-seq; algorithm; drug discovery; cancer; autoimmune disease
Online: 22 July 2024 (09:33:39 CEST)
REVIEW
|
doi:10.20944/preprints202405.1223.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
antipsychotic drug; M4 and M1 receptor agonist; negative schizophrenia symptoms; neural network; schizophrenia; trace-amine-associated receptor 1 agonist; ulataront; xanomeline
Online: 20 May 2024 (12:31:08 CEST)
REVIEW
|
doi:10.20944/preprints202307.2136.v1
Subject:
Public Health And Healthcare,
Public Health And Health Services
Keywords:
Epilepsy; Pediatric Drug Development (PDD); Therapeutic Orphans; Extrapolation of efficacy from adults to children; Antiseizure Medications (ASMs); Pediatric Investigation Plan (PIP)
Online: 1 August 2023 (02:49:45 CEST)
ARTICLE
|
doi:10.20944/preprints202307.0133.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
Hydrophilic polymers; Thermo-responsive polymers; Polymer drug delivery system; Tumor-specific targeting; Recombinant proteins; Non-covalent attachment; Tris(nitrilotriacetic acid) ligation
Online: 4 July 2023 (08:01:27 CEST)
ARTICLE
|
doi:10.20944/preprints202303.0322.v1
Subject:
Computer Science And Mathematics,
Computer Science
Keywords:
Hemolytic peptide; Network science; Half-Space Proximal Networks; Metadata Networks; Visual mining; Cluster analysis; Motif discovery; StarPep toolbox; Peptide drug discovery
Online: 17 March 2023 (10:05:05 CET)
ARTICLE
|
doi:10.20944/preprints202206.0177.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Deuterium-depleted water (DDW); deuterium-depleted organic compounds (DDOC); anticancer drug development; D/H ratio; production of metabolic water; ketogenic diet
Online: 13 June 2022 (09:49:32 CEST)
REVIEW
|
doi:10.20944/preprints202205.0037.v1
Subject:
Medicine And Pharmacology,
Dermatology
Keywords:
Melanoma; Chemo-thermo-immuno-therapy; Melanogenesis; Magnetite nanoparticle; Drug delivery system; Heat shock protein; In situ vaccine therapy; Immune checkpoint inhibitor
Online: 5 May 2022 (12:23:27 CEST)
ARTICLE
Subject:
Chemistry And Materials Science,
Nanotechnology
Keywords:
Sepiapterin; triacetyl-β-cyclodextrin (TAβCD); hydrophilic drug/cyclodextrin complexes; spray-drying; methoxy-poly(ethylene-glycol)-poly(epsilon-caprolactone) (mPEG-PCL) nanoparticles
Online: 24 May 2019 (11:42:42 CEST)
REVIEW
|
doi:10.20944/preprints201805.0426.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
biological activity; crosslinking; drug delivery; cosmetic; food-supplement; functionalization; hyaluronan applications; hyaluronan derivatives; hyaluronan synthases; hyaluronic acid; hyaluronidases; physico-chemical properties
Online: 29 May 2018 (12:13:48 CEST)
ARTICLE
|
doi:10.20944/preprints201804.0245.v1
Subject:
Chemistry And Materials Science,
Polymers And Plastics
Keywords:
Chitosan-g-PMMA amphiphilic nanoparticles; thiolated polymers; mucoadhesion; mucosal drug delivery; Caco2 and HT29-MTX cell lines; apparent permeability in vitro.
Online: 18 April 2018 (16:28:21 CEST)
ARTICLE
|
doi:10.20944/preprints202312.1193.v1
Subject:
Chemistry And Materials Science,
Applied Chemistry
Keywords:
3-amino-5-[(2,4,6-trinitrophenyl)amino]-1H-1,2,4-triazole; oxidizible salts; energetic properties; oxygen balance; stability; resistance to shock stimuli.
Online: 15 December 2023 (13:38:01 CET)
DATA DESCRIPTOR
|
doi:10.20944/preprints202311.1869.v1
Subject:
Medicine And Pharmacology,
Epidemiology And Infectious Diseases
Keywords:
Acinetobacter baumannii; healthcare-associated infections; genomic epidemiology; whole genome sequencing; cgMLST; international clones of high risk; antibiotic resistance
Online: 29 November 2023 (10:59:38 CET)
REVIEW
|
doi:10.20944/preprints202308.0733.v1
Subject:
Medicine And Pharmacology,
Urology And Nephrology
Keywords:
chronic kidney disease; uremic toxins; renal tubular transport; extracellular matrix remodeling; apoptosis resistance; inflammatory response; senescence-associated secretory phenotype factors
Online: 9 August 2023 (10:49:19 CEST)
ARTICLE
|
doi:10.20944/preprints202307.1116.v1
Subject:
Public Health And Healthcare,
Public, Environmental And Occupational Health
Keywords:
environmental stressors; pharmaceuticals; antibiotic resistance; selection pressure; public health; tolerant bacteria; environmental pollution; mutation; whole genome sequencing; single nucleotide polymorphisms
Online: 18 July 2023 (05:36:57 CEST)
REVIEW
|
doi:10.20944/preprints202302.0508.v1
Subject:
Medicine And Pharmacology,
Pulmonary And Respiratory Medicine
Keywords:
nasal function; validation; software; nasal resistance; rhinomanometry; acoustic rhinometry; peak nasal inspiratory flow meter; practice patterns; objective measurement outcomes; parameters
Online: 28 February 2023 (06:32:27 CET)
ARTICLE
|
doi:10.20944/preprints202209.0134.v1
Subject:
Medicine And Pharmacology,
Pulmonary And Respiratory Medicine
Keywords:
nasal function; validation; software; nasal resistance; rhinomanometry; acoustic rhinometry; peak nasal inspiratory flow meter; practice patterns; objective measurement outcomes; parameters
Online: 9 September 2022 (09:41:14 CEST)
ARTICLE
|
doi:10.20944/preprints202109.0129.v1
Subject:
Public Health And Healthcare,
Primary Health Care
Keywords:
antimicrobial resistance; antibiotic prescribing; acute non-complicated infections; primary care; data-based feedback; mixed logistic regression model; multi-faceted intervention
Online: 7 September 2021 (13:54:02 CEST)
REVIEW
|
doi:10.20944/preprints202103.0571.v3
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
diet; calorie restriction; ketosis; fasting; health span; lifespan; metabolic syndrome; insulin resistance; chronic non-communicable diseases; low-calorie; low-carb
Online: 12 April 2021 (13:06:01 CEST)
REVIEW
|
doi:10.20944/preprints202104.0177.v1
Subject:
Computer Science And Mathematics,
Algebra And Number Theory
Keywords:
Hydraulic resistance; Colebrook flow friction; Lambert W-function; Excel Macro Programming; Visual Basic for Applications (VBA); User Defined Functions (UDFs)
Online: 6 April 2021 (13:27:55 CEST)
ARTICLE
|
doi:10.20944/preprints202009.0453.v1
Subject:
Public Health And Healthcare,
Public, Environmental And Occupational Health
Keywords:
one health; Africa; public health; animal health; environment health; zoonosis; emerging and re-emerging diseases; food safety; antimicrobial resistance; toxicosis
Online: 19 September 2020 (10:05:32 CEST)
ARTICLE
Subject:
Biology And Life Sciences,
Agricultural Science And Agronomy
Keywords:
Pantoea agglomerans; plant growth-promotion; Solanum lycopersicum L.; indole-3-acetic acid; siderophores; arsenic resistance; complete genome; horizontal gene transfer
Online: 24 November 2019 (15:29:55 CET)
ARTICLE
|
doi:10.20944/preprints201811.0623.v1
Subject:
Biology And Life Sciences,
Plant Sciences
Keywords:
genomic selection; genomic prediction; genotyping by sequencing; pasmo resistance; pasmo severity; quantitative trait loci; single nucleotide polymorphism; Septoria linicola; flax
Online: 30 November 2018 (08:39:11 CET)
ARTICLE
|
doi:10.20944/preprints201806.0116.v1
Subject:
Engineering,
Industrial And Manufacturing Engineering
Keywords:
liquid metal sensors; liquid wire; wearables; athletic training; ankle complex; plantar flexion; resistance-based sensors; human ankle model; sensor substrate
Online: 7 June 2018 (11:15:27 CEST)
REVIEW
|
doi:10.20944/preprints202401.0676.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
HER2; breast cancer; breast neoplasms; antibody-drug conjugate; ADCs; trastuzumab emtansine; trastuzumab deruxtecan; disitamab Vedotin; ARX-788; SYD985; BL-M0701; zanidatamab zovodotin.
Online: 9 January 2024 (10:29:59 CET)
REVIEW
|
doi:10.20944/preprints202312.1480.v1
Subject:
Chemistry And Materials Science,
Nanotechnology
Keywords:
Nano-drugs; Nanoparticle; Delivery System; Vaccine; Liposome; Exosome; Stealth Effect; SLN; Inclusion and Dispersion Systems; Solid State Reactive Mixing; Nanosome; Drug Carrier
Online: 20 December 2023 (10:54:31 CET)
ARTICLE
|
doi:10.20944/preprints202306.1818.v1
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
Alternative Splicing; two-colour (GFP/RFP) Fluorescent Reporter; MAPT; Exon-Skipping; FTDP-17; High Content Screening; siRNA; Nucleic Acids Therapeutics; Drug discovery
Online: 26 June 2023 (13:55:26 CEST)
ARTICLE
|
doi:10.20944/preprints202305.1948.v1
Subject:
Public Health And Healthcare,
Public Health And Health Services
Keywords:
Kyrgyz Republic; drug-sensitive pulmonary TB; electronic register system; paper-based records; completeness; concordance; treatment initiation; treatment outcomes; SORT IT; operational research
Online: 29 May 2023 (02:49:28 CEST)
REVIEW
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
Parkinson’s disease; precision medicine; personalized medicine; GBA; Glucocerebrosidase; GCase; LRRK2; Leucine-rich repeat kinase-2; Dopamine; PD drug trials; PD risk variants
Online: 14 September 2020 (00:22:59 CEST)
REVIEW
|
doi:10.20944/preprints202309.1651.v1
Subject:
Biology And Life Sciences,
Endocrinology And Metabolism
Keywords:
cyclic AMP; cyclic PIP; insulin resistance; prostaglandylinositol cyclic phosphate; protein phosphorylation; protein kinase A; protein ser/thr phosphatase; type 2 diabetes
Online: 25 September 2023 (11:05:29 CEST)
REVIEW
|
doi:10.20944/preprints202305.1026.v1
Subject:
Medicine And Pharmacology,
Endocrinology And Metabolism
Keywords:
insulin resistance; insulin sensitivity; innate immune system, adaptive immune system, inflammatory response; obesity; visceral adipose tissue; insulin; insulin receptor; insulin signaling
Online: 15 May 2023 (10:37:48 CEST)
COMMUNICATION
|
doi:10.20944/preprints202206.0374.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
antimicrobial resistance; CTX-M-1; Enterobactericeae,; Escherichia coli; extended-spectrum β-lactamase; food safety; IncI1; next-generation sequencing; One Health; virulence
Online: 28 June 2022 (04:18:22 CEST)
REVIEW
|
doi:10.20944/preprints202108.0174.v1
Subject:
Biology And Life Sciences,
Agricultural Science And Agronomy
Keywords:
lactic acid bacteria; food-producing animals; dairy products; health benefits; One health; antimicrobial resistance; probiotics; starter cultures; adjunct cultures; protective cultures.
Online: 7 August 2021 (00:17:15 CEST)
REVIEW
|
doi:10.20944/preprints201908.0186.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
heat shock protein (HSP); extracellular vesicle (EV); exosome; oncosome; immune evasion; resistance-associated secretory phenotype (RASP); EMT; hypoxia; biomarker; liquid biopsy
Online: 17 August 2019 (16:15:01 CEST)
ARTICLE
|
doi:10.20944/preprints201803.0140.v1
Subject:
Chemistry And Materials Science,
Surfaces, Coatings And Films
Keywords:
laser surface glazing; Ti6Al4V alloy; FEA; thermal model; biomedical application; heating and cooling rates; depth of modified zone; hardness; wear resistance
Online: 19 March 2018 (06:42:48 CET)
ARTICLE
|
doi:10.20944/preprints202401.0070.v2
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
cancer growth; tumor metastasis; cancer's Warburg effect; p53; p53 (re)activators; mitochondrial apoptosis; cytochrome c release; tumoricidal drug effect
Online: 4 January 2024 (09:34:19 CET)
ARTICLE
|
doi:10.20944/preprints202304.0534.v1
Subject:
Medicine And Pharmacology,
Otolaryngology
Keywords:
micro injection molding; 3D printing; rapid tooling; digital light processing; implant; drug delivery system; dexamethasone; anti-inflammatory; TNF-α; biocompatibility; inner ear therapy
Online: 19 April 2023 (03:57:41 CEST)
ARTICLE
|
doi:10.20944/preprints202002.0003.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
drug repositioning/repurposing; dopamine transporter (DAT); benztropine; tumoroids; signal transducer and activator of transcription (STAT); circulating tumor cells (CTC); three-dimensional (3D) culture
Online: 3 February 2020 (03:16:54 CET)
ARTICLE
|
doi:10.20944/preprints202401.1987.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
Maresin-like (MarL); specialized proresolving mediators (SPMs), antimicrobial lipids; fatty acids; bactericidal antibacterial; antimicrobial resistance; microbial infections; biofilms; gram-positive; gram-negative
Online: 29 January 2024 (05:46:04 CET)
REVIEW
|
doi:10.20944/preprints202310.0014.v1
Subject:
Medicine And Pharmacology,
Endocrinology And Metabolism
Keywords:
Non-Communicable Diseases (NCDs); Perivascular Adipose Tissue (PVAT); Endothelial Dysfunction (ED); Cardiovascular Diseases (CVDs); Insulin Resistance (IR); Type 2 Diabetes Mellitus (T2DM)
Online: 2 October 2023 (07:33:04 CEST)
REVIEW
|
doi:10.20944/preprints202309.0459.v2
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
migraine disorders; headache disorders; nociceptive pain; analgesics; calcitonin gene-related peptide; pituitary adenylate cyclase-activating polypeptide (PACAP); vasoactive intestinal peptide; adrenomedullin; neuropeptides; drug development
Online: 17 October 2023 (10:50:15 CEST)
ARTICLE
|
doi:10.20944/preprints202308.1050.v1
Subject:
Chemistry And Materials Science,
Applied Chemistry
Keywords:
transungual; antifungal nail lacquer; Itraconazole Nail Medication; Nail Drug Uptake; Nail penetration; Nail Plate Application; itraconazole hydrochloride; Topical Nail Polish; nail clipping; Nail Diffusion
Online: 15 August 2023 (07:06:34 CEST)
ARTICLE
|
doi:10.20944/preprints202202.0046.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
Cancer; tumor homing peptide; in silico drug discovery; complex network; chemical space network; centrality measure; similarity searching, group fusion; motif discovery; starPep toolbox software
Online: 3 February 2022 (10:14:05 CET)
REVIEW
|
doi:10.20944/preprints202005.0234.v1
Subject:
Computer Science And Mathematics,
Artificial Intelligence And Machine Learning
Keywords:
SIRD; Twitter; GHSI; Pre-symptomatic; EHR; Contact tracing; On-line survey; qRT-PCR; X-ray; CT/HRCT; CNN; Autoencoder; Drug affinity; CPI; and Inflation.
Online: 14 May 2020 (11:25:57 CEST)
REVIEW
|
doi:10.20944/preprints202405.2001.v1
Subject:
Biology And Life Sciences,
Plant Sciences
Keywords:
mosaic-virus; novel viruses; pathogen-derived resistance; RNAi; artificial microRNA; plant gene editing; NB-LRR protein; nanoparticle RNA delivery; plant disease; crop protection
Online: 30 May 2024 (10:51:19 CEST)
ARTICLE
|
doi:10.20944/preprints202403.1444.v1
Subject:
Engineering,
Aerospace Engineering
Keywords:
Ice Formation; Aircraft Ice Detection; Hazard Management; Graphene Sensors; In-Flight Safety Technology; Real-time Ice Monitoring; Resistance Signal Analysis; Pedot:PSS; Climatic chamber
Online: 25 March 2024 (08:47:38 CET)
COMMUNICATION
|
doi:10.20944/preprints202402.0777.v1
Subject:
Biology And Life Sciences,
Animal Science, Veterinary Science And Zoology
Keywords:
Toxoplasma gondii; pig genetic resistance; interleukin-18 gene; immunity pathway; serological sur-vey; pork meat safety; alternative prevention measures; novel investigation; One Health
Online: 14 February 2024 (05:35:06 CET)
REVIEW
|
doi:10.20944/preprints202306.1853.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
interleukin-1 beta (IL-1β); immune-checkpoint inhibitors (ICIs); non-small cell lung cancer (NSCLC); programmed death ligand 1 (PD-L1); therapeutic resistance
Online: 27 June 2023 (07:16:09 CEST)
ARTICLE
|
doi:10.20944/preprints202204.0183.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
resistant TNBC; intra-tumoral heterogeneity; breast cancer relapse; breast cancer epigenome; me-tastasis prevention; intrinsic resistance of cancer; tumor adaptability; targeting resistant cancer
Online: 20 April 2022 (04:16:31 CEST)
ARTICLE
|
doi:10.20944/preprints202406.0009.v1
Subject:
Medicine And Pharmacology,
Pulmonary And Respiratory Medicine
Keywords:
EGFR mutation; osimertinib; acquired resistance; secondary mutations; novel drugs; non-small cell lung cancer; epithelial to mesenchymal transition; MET gene amplification; Ba/F3 cells
Online: 4 June 2024 (02:53:41 CEST)
ARTICLE
|
doi:10.20944/preprints202312.1788.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
cystic fibrosis; CFTR; phagocytosis; bacterial killing; Pseudomonas aeruginosa; macrophage polarization; ERK1/2; azithromycin; antibiotic resistance.
Online: 25 December 2023 (04:45:25 CET)
ARTICLE
|
doi:10.20944/preprints202310.1219.v1
Subject:
Environmental And Earth Sciences,
Soil Science
Keywords:
road construction; soil stabilization; soil binders; soil compressive strength; soil capillary forces; frost resistance; waste additives; industrial waste; pyrolytic wax; emulsions; soil water absorption
Online: 20 October 2023 (11:01:31 CEST)
ARTICLE
|
doi:10.20944/preprints202405.1511.v1
Subject:
Biology And Life Sciences,
Cell And Developmental Biology
Keywords:
Breast cancer; network pharmacology; text mining; drug therapy; genes; pathway analysis; biological process; protein-protein interaction; degree and betweenness; molecular docking; meristematic cells; anti-mitotic; hepatotoxicity
Online: 23 May 2024 (07:34:57 CEST)
REVIEW
|
doi:10.20944/preprints202311.0529.v1
Subject:
Public Health And Healthcare,
Primary Health Care
Keywords:
SARS-CoV-2; Papain-like protease; COVID-19; Molecular modelling; Molecular dynamics simulations; Drug discovery; Antiviral drugs; Inhibitors; Therapeutic agents; therapeutic targets; Irreversible inhibitors; Repurposing drugs
Online: 8 November 2023 (16:11:55 CET)
ARTICLE
|
doi:10.20944/preprints202308.1047.v1
Subject:
Medicine And Pharmacology,
Ophthalmology
Keywords:
Age-related Macular Degeneration (AMD); Cornea; docosahexaenoic acid (DHA); drug delivery; non-invasive ocular delivery platform (NIODP); ocular disease; omega-3; retina; retinal delivery; retinal dis
Online: 14 August 2023 (15:18:22 CEST)
REVIEW
|
doi:10.20944/preprints202312.0717.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
Cancer immunotherapy 1; Resistance 2; Tumor microenvironment 3; Combination therapies 4; Immune checkpoint targets 5; Adoptive cell therapies 6; Cancer vaccines 7; Personalized medicine 8.
Online: 11 December 2023 (17:53:38 CET)
REVIEW
|
doi:10.20944/preprints202311.1186.v1
Subject:
Public Health And Healthcare,
Public, Environmental And Occupational Health
Keywords:
instrument development; principal component analysis; salutogenesis; the salutogenic survey on sustainable working life for nurses (SalWork-N); generalized and specific resistance resources; specific enhancing resources
Online: 17 November 2023 (16:09:07 CET)
ARTICLE
|
doi:10.20944/preprints202205.0177.v1
Subject:
Engineering,
Civil Engineering
Keywords:
cross-section resistance; slenderness limit; high strength steel; tubular sections; very-high strength steel; cold-formed; thin-walled circular hollow sections; finite element analysis; ANSYS
Online: 13 May 2022 (04:07:01 CEST)
ARTICLE
|
doi:10.20944/preprints202203.0345.v1
Subject:
Biology And Life Sciences,
Insect Science
Keywords:
insecticide-treated nets (ITN); pyrethroid; mosquito; strain characterisation; insecticide resistance; method development; durability monitoring; product evaluation; quality control (QC); dual active ingredients (dual-AI); bioefficacy
Online: 25 March 2022 (14:12:38 CET)
REVIEW
|
doi:10.20944/preprints202005.0089.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
access to medicines; access to antibuotics; impact of access to medicines on public health; problems associated with access; use; abuse of antibiotics resistance; aware; Africa
Online: 5 May 2020 (17:03:07 CEST)
ARTICLE
|
doi:10.20944/preprints202407.0194.v1
Subject:
Biology And Life Sciences,
Endocrinology And Metabolism
Keywords:
thyroid hormone; TSH; reference values; fT3/fT4 ratio; peripheral thyroid hormone resistance; MCT8 deficiency; THRA mutations; SECSIBP2 mutations; SLC16A2 mutations
Online: 2 July 2024 (10:48:35 CEST)
REVIEW
|
doi:10.20944/preprints202305.0658.v1
Subject:
Chemistry And Materials Science,
Nanotechnology
Keywords:
Nanotechnology application; nano-suspension techniques; nano-emulsion techniques; bioactive constituents of plant; phytochemicals (PHYs); poor water solubility; drug delivery systems (DDSs); toxicological risks of NPs; clinical application of NPs
Online: 9 May 2023 (12:50:27 CEST)
ARTICLE
|
doi:10.20944/preprints202304.0625.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
adverse drug reaction; cisplatin liposomes; circulating tumor cells; enhanced permeability and retention effect; nephrotoxicity; pulmonary metastasis of pancreatic cancer; quality of life; recurrent liver metastases from primary nasal cancer
Online: 20 April 2023 (07:52:10 CEST)
REVIEW
|
doi:10.20944/preprints202407.2331.v1
Subject:
Medicine And Pharmacology,
Cardiac And Cardiovascular Systems
Keywords:
Key words: nitroglycerin; glutathione; mitochondria; complex I; eNOS; nitric oxide; S-nitrosylation; S-glutathiolation; superoxide; acute heart failure; right heart failure; diuretic resistance; refractory angina; NLRP3 inflammasome.
Online: 29 July 2024 (15:06:08 CEST)
ARTICLE
|
doi:10.20944/preprints201807.0317.v3
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Boswellia serrata Roxb.; Curcuma longa L.; intestinal bowel diseases (IBD); Caco-2; PBMC; HMC-1.1; mast cells; cytokines; trans epithelial electrical resistance (TEER); reactive oxygen species (ROS)
Online: 8 November 2018 (04:53:46 CET)
ARTICLE
|
doi:10.20944/preprints202408.0031.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
EMA, DGDA, Drug Regulatory Authorities, Manufacturing Guidelines, Quality Medicine, Good Laboratory Practice, cGMP,GMP,GLP,IPQC,QC,QA,Quality Control, Quality Assurance, Current Good Manufacturing Practice, Good Manufacturing Practice,
Online: 1 August 2024 (11:15:43 CEST)
ARTICLE
|
doi:10.20944/preprints202208.0324.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
T cytotoxic cells; Leukocyte-associated Immunoglobulin-like Receptor-1; LAIR-1; Hepatitis C virus genotype 4; HCV G4; hepatocellular carcinoma; cirrhosis; immune inhibitory checkpoints; inflammation; prognosis; insulin resistance
Online: 17 August 2022 (11:38:10 CEST)
ARTICLE
|
doi:10.20944/preprints202405.0998.v1
Subject:
Biology And Life Sciences,
Animal Science, Veterinary Science And Zoology
Keywords:
Escherichia coli; pigs; close human contacts; One Health; antibiotic resistance; whole genome sequencing; virulence factors; core genome MLST and hierarchical clustering; sequence type complex 10; South Africa
Online: 15 May 2024 (04:32:27 CEST)
ARTICLE
|
doi:10.20944/preprints202401.1960.v1
Subject:
Chemistry And Materials Science,
Ceramics And Composites
Keywords:
high temperature cementitious materials, cement well exposure tests, calcium-aluminate well cement, function cement tests, well cement CO2 resistance, finite element modeling of well cement, calcium-free well cement.
Online: 29 January 2024 (09:49:47 CET)
REVIEW
|
doi:10.20944/preprints202206.0316.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
Cancer surgery; Cancer radiotherapy; Cancer immunotherapy; Cancer stroma; Cancer-associated fibroblasts; Carcinogenesis; Cancer resistance to immunotherapy; Exosomes; Hypoxia; Neutrophil extracellular traps; Sphingomyelin; Neutral sphingomyelinase; Tumor microenvironment; Tumor-associated macrophages
Online: 22 June 2022 (10:25:07 CEST)