HYPOTHESIS
|
doi:10.20944/preprints202310.2100.v2
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
Alzheimer’ s disease; Angiotensin II; Angiotensin-converting enzyme 2; COVID-19; Brain; Dementia; Furin; Neurological disorders; SARS-CoV-2; Spike protein
Online: 12 February 2024 (15:48:57 CET)
ARTICLE
|
doi:10.20944/preprints202308.2083.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
COVID-19; SARS-CoV-2 spike protein 1 (S1); methylglyoxal; MG-H1; Glyoxalase 1; RAGE; inflammation; Nrf2; BEAS-2B; A549
Online: 30 August 2023 (12:02:02 CEST)
REVIEW
|
doi:10.20944/preprints202308.0520.v1
Subject:
Medicine And Pharmacology,
Epidemiology And Infectious Diseases
Keywords:
SARS-CoV-2; spike protein; mutations; viral infectivity; pathogenesis; vaccine efficacy; immune evasion; antibody neutralization; T-cell response; therapeutic targeting
Online: 7 August 2023 (10:12:28 CEST)
ARTICLE
|
doi:10.20944/preprints202306.0068.v1
Subject:
Medicine And Pharmacology,
Other
Keywords:
3D printed scaffolds; carbon nanotube; capped carbon nanotube; protein kinase A; pseudomonas elastase; exotoxin A; alpha-hemolysin; shiga toxin 2a
Online: 5 June 2023 (02:56:10 CEST)
REVIEW
|
doi:10.20944/preprints202301.0099.v1
Subject:
Biology And Life Sciences,
Cell And Developmental Biology
Keywords:
Atg8; autophagic receptor; Cue5; SAR; selective autophagy; selective autophagy receptor; ubiquitin; ubiquitin-binding domain; ubiquitin-binding protein; ubiquitin-binding receptor
Online: 5 January 2023 (04:33:12 CET)
ARTICLE
|
doi:10.20944/preprints202111.0558.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
Yersinia pestis; vaccine; guinea pigs; bubonic plague; inactivated vaccine; phage; bacterial ghost; protection; protein-E-mediated lysis, holin-endolysin system
Online: 30 November 2021 (11:08:18 CET)
REVIEW
|
doi:10.20944/preprints202109.0501.v2
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
Antigen Selection; Epitope Selection; Antibody Targeting; Epitope Accessibility; Antibody Engineering; Protein Engineering; Drug Targeting; Model-Informed Drug Discovery and Development
Online: 3 November 2021 (08:26:47 CET)
ARTICLE
|
doi:10.20944/preprints202107.0295.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
SARS-CoV-2 spike protein; ACE2 host receptor; nanobodies; molecular dynamics; mutational sensitivity; binding free energy; allosteric interactions; signal transmission
Online: 13 July 2021 (11:18:02 CEST)
ARTICLE
|
doi:10.20944/preprints202106.0553.v1
Subject:
Engineering,
Bioengineering
Keywords:
Iron-oxide nanoparticles, primary-secondary method, diagnostics of cancer, A549 cell line, transferrin protein receptors, adenocarcinoma, biotin-streptavidin, biotinylated antibodies
Online: 23 June 2021 (09:17:59 CEST)
ARTICLE
|
doi:10.20944/preprints202103.0059.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Metallothionein (MT); Scientific discovery; Scientific pursuit; Research strategies; upward looking research; Exploratory research; Protein function; Compensation; Moonlighting; multifunctional proteins; Vestiges
Online: 2 March 2021 (09:39:39 CET)
ARTICLE
|
doi:10.20944/preprints202102.0296.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
End-Stage Renal Disease, Chronic Kidney Disease, Wnt-Pathway, R-Spondin 1, β-Catenin, Dickkopf-Related Protein 1, and Sclerostin.
Online: 12 February 2021 (10:08:22 CET)
ARTICLE
|
doi:10.20944/preprints202002.0148.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
cell stress response; stressome; extracellular vesicle; heat shock protein 90 (HSP90); cell division control 37 (CDC37); prostate cancer; exosome; ectosome
Online: 11 February 2020 (14:50:14 CET)
ARTICLE
|
doi:10.20944/preprints201911.0399.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
olivo-ponto-cerebellar atrophy (OPCA); Purkinje cells; Calcium/calmodulin dependent protein kinase II (CAMK2); Plastin (Fimbrin); Hirano bodies; Huntington’s disease
Online: 30 November 2019 (14:47:30 CET)
ARTICLE
|
doi:10.20944/preprints201910.0283.v1
Subject:
Medicine And Pharmacology,
Hematology
Keywords:
chronic inflammation; biomarker panels; leukocyte count; C-reactive protein; related syndromes and pathologies; risk assessment; screening programmes; ageing; elderly's health
Online: 25 October 2019 (04:16:43 CEST)
REVIEW
|
doi:10.20944/preprints201811.0268.v1
Subject:
Biology And Life Sciences,
Cell And Developmental Biology
Keywords:
mitochondria; stress response; mitophagy; mitochondrial dynamics; mitochondrial unfolded protein response (UPRmt); quality control; prohibitins; PHB complex; PHB-1; PHB-2
Online: 12 November 2018 (05:23:36 CET)
REVIEW
|
doi:10.20944/preprints201810.0204.v2
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
DNA origami; aptamer; DNA nanotechnology; protein nano array; biosensor; logic gate; enzyme cascade; drug delivery system; targeted therapy; molecular robotics
Online: 22 October 2018 (10:57:21 CEST)
REVIEW
|
doi:10.20944/preprints201809.0040.v1
Subject:
Medicine And Pharmacology,
Cardiac And Cardiovascular Systems
Keywords:
Triggering receptor expressed on myeloid cells, DNAX-activating protein 12, cardiovascular diseases, atherosclerosis, coronary arteries diseases, acute myocardial infract, endocarditis
Online: 3 September 2018 (14:50:17 CEST)
ARTICLE
|
doi:10.20944/preprints201808.0298.v1
Subject:
Biology And Life Sciences,
Anatomy And Physiology
Keywords:
Heterodimeric G protein coupled receptor; saturation transfer difference nuclear magnetic resonance spectroscopy; differential scanning calorimetry; circular dichroism; intrinsic fluorescence spectroscopy
Online: 17 August 2018 (11:15:39 CEST)
ARTICLE
|
doi:10.20944/preprints202407.1889.v1
Subject:
Medicine And Pharmacology,
Emergency Medicine
Keywords:
Bowel obstruction; Emergency surgery; Machine learning; Postoperative complications; Artificial intelligence; Risk prediction; C-reactive protein; Malignant obstruction; K-nearest neighbors algorithm
Online: 24 July 2024 (12:38:09 CEST)
ARTICLE
|
doi:10.20944/preprints202407.0097.v1
Subject:
Medicine And Pharmacology,
Pathology And Pathobiology
Keywords:
advanced glycation end products (AGEs); metabolic dysfunction; protein relation structure-function; spectroscopic analysis; conformational changes; catalytic aging; molecular wear; enzymatic rescue
Online: 2 July 2024 (02:28:47 CEST)
ARTICLE
|
doi:10.20944/preprints202404.0469.v1
Subject:
Biology And Life Sciences,
Biophysics
Keywords:
Alzheimer’ s disease; amyloid β peptide; human serum albumin; low-molecular-weight ligand; protein-ligand interaction; surface plasmon resonance spectroscopy
Online: 7 April 2024 (10:18:10 CEST)
REVIEW
|
doi:10.20944/preprints202404.0089.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
bacterial nucleoid; phase-contrast microscopy; DNA polymer physics; protein depletion; chromosome arms; replication bubble or orisome; active and passive DNA segregation.
Online: 1 April 2024 (13:11:12 CEST)
ARTICLE
|
doi:10.20944/preprints202312.0522.v1
Subject:
Biology And Life Sciences,
Aquatic Science
Keywords:
liver histology; liver index; sustainable feed; poultry by-product meal; Hermetia illucens meal; plant-protein; lipid metabolism; fish welfare; blood biochemistry
Online: 7 December 2023 (11:57:53 CET)
REVIEW
|
doi:10.20944/preprints202310.1640.v1
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
Tracer development; neuroinflammation; pneumonia; myocarditis; translocator protein (TSPO); cyclooxygenase-2 (COX-2); positron emission tomography (PET); single-photon emission tomography (SPECT)
Online: 25 October 2023 (11:31:31 CEST)
REVIEW
|
doi:10.20944/preprints202309.2000.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Cluster of differentiation 74 (CD74); oncogenic fusion protein; fusion gene; CD74-ROS1; CD74-NTRK1; CD74-NRG1; CD74-NRG2a; CD74-PDGFRB; cancer.
Online: 29 September 2023 (04:35:12 CEST)
ARTICLE
|
doi:10.20944/preprints202307.1289.v1
Subject:
Chemistry And Materials Science,
Food Chemistry
Keywords:
salmon analog; caviar analog; plant-based foods; voltammetry; glassy carbon electrode; antioxidant capacity; 3D printing; isoflavones; isolated soy protein; white beans
Online: 19 July 2023 (09:51:58 CEST)
REVIEW
|
doi:10.20944/preprints202205.0037.v1
Subject:
Medicine And Pharmacology,
Dermatology
Keywords:
Melanoma; Chemo-thermo-immuno-therapy; Melanogenesis; Magnetite nanoparticle; Drug delivery system; Heat shock protein; In situ vaccine therapy; Immune checkpoint inhibitor
Online: 5 May 2022 (12:23:27 CEST)
REVIEW
|
doi:10.20944/preprints202110.0005.v1
Subject:
Biology And Life Sciences,
Endocrinology And Metabolism
Keywords:
Brown adipose tissue; beige adipose tissue; obesity; cold exposure; uncoupling protein-1, beta-adrenergic receptor; energy expenditure; adipose browning; micro-RNA
Online: 1 October 2021 (11:30:39 CEST)
ARTICLE
|
doi:10.20944/preprints202106.0393.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
clear cell renal cell carcinoma (ccRCC); LOX-1 protein; volatile compounds (VOCs); prognostic biomarker; urine; gas chromatography mass spectrometer (GC/MS)
Online: 15 June 2021 (10:29:39 CEST)
ARTICLE
|
doi:10.20944/preprints202010.0274.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
protein aggregation; inhibition of amyloid fibril formation; antioxidants; polyphenols; cystatin C; NAC and vitamin C; amyloid fibrils; stefin B aggregation; TEM
Online: 13 October 2020 (10:49:14 CEST)
ARTICLE
|
doi:10.20944/preprints202008.0632.v1
Subject:
Computer Science And Mathematics,
Mathematical And Computational Biology
Keywords:
Blockchain; P2P Networks; Nucleobase DNA/RNA sequence; Gene Expression; Cell Population; Epigenetics; Methylation; Consensus; Hash Algorithm; Triple Codons; Protein Synthesis; Cryptocurrency
Online: 28 August 2020 (10:33:42 CEST)
ARTICLE
|
doi:10.20944/preprints202002.0234.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
adeno-associated virus; protein sequence analysis; overlapping genes; amino acid depletion; cysteine depletion; tyrosine depletion; capsid design; membrane-binding amphipathic helix
Online: 17 February 2020 (02:42:39 CET)
ARTICLE
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Mediator: stress; MCHM; Med15; Snf1; polyQ; protein chaperone; master variator; intrinsically disordered regions; yeast; hydrotrope; transcription factors; Myc tag; inorganic phosphate
Online: 3 February 2020 (13:37:07 CET)
REVIEW
|
doi:10.20944/preprints201908.0186.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
heat shock protein (HSP); extracellular vesicle (EV); exosome; oncosome; immune evasion; resistance-associated secretory phenotype (RASP); EMT; hypoxia; biomarker; liquid biopsy
Online: 17 August 2019 (16:15:01 CEST)
ARTICLE
|
doi:10.20944/preprints201804.0079.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Alzheimer’s disease (AD); amyloid precursor protein (APP); familial AD (FAD); sporadic AD (SAD); BACE1 inhibitors; APP-independent generation of beta amyloid
Online: 6 April 2018 (15:16:08 CEST)
REVIEW
|
doi:10.20944/preprints201802.0047.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Alzheimer disease; Amyloid β-protein; Antibodies; Cross-reactions; Nucleotide aptamers; Oligonucleotide ligands; Systematic evolution of ligands by exponential enrichment; Specificity; Therapeutics
Online: 5 February 2018 (22:37:02 CET)
ARTICLE
|
doi:10.20944/preprints201703.0232.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
Filamentous phage; M13; gp1; Zonula occludens toxin (Zot); phage assembly; assembly 27 complex; ATPase; membrane protein; molecular hinge; secretion; Walker motifs
Online: 31 March 2017 (11:13:40 CEST)
ARTICLE
|
doi:10.20944/preprints202405.0172.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
c-Jun; G-protein; Gα q-coupled receptor; galanin; ISA-2011B; phosphatidylinositol 4-phosphate 5 kinase; RGS2; TRPM3; TRPM8
Online: 3 May 2024 (07:40:09 CEST)
ARTICLE
|
doi:10.20944/preprints202404.0108.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
SARS-CoV-2; Nucleocapsid protein; Monoclonal and Polyclonal Antibodies; Enzyme-Linked Immunoassay; Peptide epitope mapping; Viral Quality Assurance; RADx; COVID-19 diagnostics
Online: 1 April 2024 (17:21:17 CEST)
REVIEW
|
doi:10.20944/preprints202403.0173.v1
Subject:
Biology And Life Sciences,
Insect Science
Keywords:
Chemosensory proteins; 4 Cysteines Soluble Proteins; mucin; actin skeleton regulatory complex; nuclear pore complex protein; transcription initiation factor; gene regulation; immune response.
Online: 4 March 2024 (17:02:04 CET)
REVIEW
|
doi:10.20944/preprints202401.1939.v1
Subject:
Biology And Life Sciences,
Life Sciences
Keywords:
Chemical evolution; enantiomeric excess; chirality; racemate; self-assembly; self-replication; life on earth; prebiotic chemistry; protein folding; conformation; segregation; Murchison meteorite; Ryugu
Online: 27 January 2024 (10:55:42 CET)
ARTICLE
|
doi:10.20944/preprints202308.1955.v1
Subject:
Biology And Life Sciences,
Plant Sciences
Keywords:
potato; CLE peptide; CLE4; NIN-LIKE PROTEIN (NLP); nitrate; nitrate-responsive elements (NREs); shoot apical meristem (SAM); Identity of Tuber1 (IT1); tuber
Online: 29 August 2023 (08:41:31 CEST)
ARTICLE
|
doi:10.20944/preprints202308.0828.v1
Subject:
Biology And Life Sciences,
Biophysics
Keywords:
global protein dynamics; software integration workflows; cryo-electron microscopy; normal mode analysis; elastic network models; ensemble analysis; principal component analysis; hybrid simulations
Online: 10 August 2023 (10:52:04 CEST)
REVIEW
|
doi:10.20944/preprints202305.1708.v1
Subject:
Biology And Life Sciences,
Life Sciences
Keywords:
Cytoplasmic membrane homeostasis; Pathogenicity; Pathogenic fungi; Membrane lipid metabolism; Membrane curvature; Transmembrane protein; Cell wall components; Cytoskeleton; Growth and development; Host infection
Online: 24 May 2023 (10:38:22 CEST)
REVIEW
|
doi:10.20944/preprints202305.0606.v1
Subject:
Medicine And Pharmacology,
Anatomy And Physiology
Keywords:
alcoholic fatty liver; adenosine monophosphate activated kinase; sterol regulatory element binding protein 1c; peroxisome proliferator activated receptor , oxidative stress; cytochrome P450 2E1
Online: 9 May 2023 (08:38:13 CEST)
ARTICLE
|
doi:10.20944/preprints202302.0176.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
acute myocardial infarction (AMI); cardiac Troponin I (cTnI); chemiluminescence; biosensor; luminol; monoclonal antibody; flow injection assay; microfluidic system; monolithic column; protein expression
Online: 10 February 2023 (02:58:24 CET)
ARTICLE
|
doi:10.20944/preprints202111.0552.v1
Subject:
Medicine And Pharmacology,
Orthopedics And Sports Medicine
Keywords:
ozone; ozone therapy; cytokines; biomarkers; IL-6; inflammation; chronic inflammation; IGF-1; anabolism; knee osteoarthritis; pain; function; c-reactive protein; uric acid
Online: 29 November 2021 (19:08:10 CET)
ARTICLE
|
doi:10.20944/preprints202103.0055.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Fractional complex moment; SARS-CoV-2; coronaviruses; spike protein sequence; Pearson correlation coefficient; semi-covariance coefficient; positive-correlative and negative-correlative domains
Online: 2 March 2021 (09:30:12 CET)
ARTICLE
|
doi:10.20944/preprints202101.0390.v1
Subject:
Biology And Life Sciences,
Anatomy And Physiology
Keywords:
protein structure; relative solvent accessibility; secondary structure; phylogeny; models of sequence evolution; gene tree-species tree discordance; incomplete lineage sorting; Ctenophora; Porifera
Online: 19 January 2021 (16:46:25 CET)
ARTICLE
|
doi:10.20944/preprints202009.0374.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
aldosterone; apoptosis; cardiac myocyte; eplerenone; fibrosis; finerenone; G protein-coupled receptor kinase (GRK)-5; mineralocorticoid receptor; mineralocorticoid receptor antagonist (MRA); signal transduction
Online: 17 September 2020 (05:24:29 CEST)
ARTICLE
|
doi:10.20944/preprints202006.0199.v1
Subject:
Medicine And Pharmacology,
Cardiac And Cardiovascular Systems
Keywords:
C-reactive protein; platelet to lymphocyte ratio; neutrophil to lymphocyte ratio; hematocrit; red blood cell distribution width; contrast induced nephropathy; coronary intervention
Online: 16 June 2020 (07:51:20 CEST)
ARTICLE
|
doi:10.20944/preprints201907.0144.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
longevity; life expectancy; CODAS syndrome; Perrault syndrome; protease target substrates; respiratory complex assembly; oxidative stress; glutathione pathway; lysosomal degradation; fidelity protein synthesis
Online: 10 July 2019 (10:18:22 CEST)
ARTICLE
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Colorectal Cancer Cells; Gastric Cancer Cells; Cholangiocarcinoma Cells; Hepatocarcinoma Cells; Exosomes; FZD 10 protein; FZD10-mRNA; FZD10-mRNA Silenced Cells; Cell Proliferation
Online: 9 July 2019 (14:19:22 CEST)
ARTICLE
|
doi:10.20944/preprints201906.0259.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
long non-coding RNA; cell type specific; alternative splicing; functional enrichment; RNA-binding proteins; protein binding lncRNA sponges; secondary RNA structure; cancer
Online: 26 June 2019 (05:23:29 CEST)
ARTICLE
|
doi:10.20944/preprints201808.0491.v1
Subject:
Medicine And Pharmacology,
Endocrinology And Metabolism
Keywords:
type 2 diabetes mellitus; carotid intima-media thickness; glucagon-like peptide-1; dipeptidyl peptidase-4; clusterin; amylin; secreted Frizzled-related protein-4
Online: 29 August 2018 (09:38:37 CEST)
REVIEW
|
doi:10.20944/preprints202405.2001.v1
Subject:
Biology And Life Sciences,
Plant Sciences
Keywords:
mosaic-virus; novel viruses; pathogen-derived resistance; RNAi; artificial microRNA; plant gene editing; NB-LRR protein; nanoparticle RNA delivery; plant disease; crop protection
Online: 30 May 2024 (10:51:19 CEST)
REVIEW
|
doi:10.20944/preprints202403.0881.v2
Subject:
Medicine And Pharmacology,
Transplantation
Keywords:
COVID-19 vaccine; genetic vaccine; blood product; blood transfusion; spike protein; post-vaccination syndrome; harm– benefit assessment; prion; spikeopathy; inspection standard; diagnostic criteria
Online: 29 May 2024 (08:33:19 CEST)
COMMUNICATION
|
doi:10.20944/preprints202402.0581.v1
Subject:
Biology And Life Sciences,
Animal Science, Veterinary Science And Zoology
Keywords:
bone morphogenetic protein receptor-1B (BMPR1B); fecundity (Fec); growth differentiation factor 9 (GDF9); polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP); sheep
Online: 9 February 2024 (19:15:18 CET)
ARTICLE
|
doi:10.20944/preprints202401.0219.v1
Subject:
Medicine And Pharmacology,
Epidemiology And Infectious Diseases
Keywords:
CRE; ESBL; extended spectrum beta lactamase; non-carbapenemase-producing; ertapenem-resistant; meropenem-susceptible; porin loss; outer-membrane protein; mobile genetic elements; molecular epidemiology
Online: 3 January 2024 (09:43:24 CET)
Subject:
Biology And Life Sciences,
Insect Science
Keywords:
4 cysteines soluble proteins; transcription initiation factor; actin skeleton regulatory complex; nuclear pore complex protein; rho gtpase activator; mucin; lipid metabolism; immune response
Online: 27 December 2023 (05:39:13 CET)
HYPOTHESIS
|
doi:10.20944/preprints202305.0415.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
evolution of the ribosome; evolution of life; genetic code; evolution of translation; origins of protein biosynthesis; RNA machines; RNA world; origin of life
Online: 6 May 2023 (10:26:26 CEST)
ARTICLE
|
doi:10.20944/preprints202304.0587.v1
Subject:
Medicine And Pharmacology,
Dentistry And Oral Surgery
Keywords:
cardiovascular diseases; salivary biomarkers; myocardial infarction; saliva; salivary glands; adiponectin; C-reactive protein; Chemokine CCL3; macrophage inflammatory proteins; periodontitis; inflammation mediators; risk assessment
Online: 19 April 2023 (10:40:14 CEST)
ARTICLE
|
doi:10.20944/preprints202202.0118.v1
Subject:
Chemistry And Materials Science,
Analytical Chemistry
Keywords:
protein-DNA interactions; DNA recognition; transcription factors; DNA binding domains; con-formational change; nuclear magnetic resonance; circular dichroism; control of gene expression; homeodomains.
Online: 8 February 2022 (14:53:06 CET)
ARTICLE
|
doi:10.20944/preprints202105.0461.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
ACE2; Ang II; AT1R; AT2R; angiotensin (1-7); β-arrestin; CFTR; COVID-19; ENaC; GPCR; MERS-CoV; SARS-CoV2; SARS-CoV; G-protein
Online: 20 May 2021 (09:28:37 CEST)
ARTICLE
|
doi:10.20944/preprints202404.0304.v1
Subject:
Public Health And Healthcare,
Physical Therapy, Sports Therapy And Rehabilitation
Keywords:
Multiple myeloma; Nordic Walking; intermittent fasting; sclerostin; Dickkopf-related protein 1; osteoprotegrin; Tartrate-resistant acid phosphatase 5b; Wnt pathway; vitamin D; cancer rehabilitation; elderly
Online: 3 April 2024 (14:27:03 CEST)
ARTICLE
|
doi:10.20944/preprints202403.1591.v1
Subject:
Chemistry And Materials Science,
Other
Keywords:
tau protein; histidine containing fragments; copper(II) complex; zinc(II) complex; nickel(II) complex; copper(II) catalysed oxidation; potentiometry; UV-Vis spectroscopy; CD spectroscopy
Online: 26 March 2024 (14:29:44 CET)
ARTICLE
|
doi:10.20944/preprints202403.1085.v1
Subject:
Biology And Life Sciences,
Agricultural Science And Agronomy
Keywords:
Solanum tuberosum; dry matter; starch; protein; ascorbic acid; carotenoids; anthocyanins; total acidity; reducing sugars; phenolic compounds; antioxidant activity; meteorological conditions of the growing season
Online: 19 March 2024 (10:17:31 CET)
ARTICLE
|
doi:10.20944/preprints202308.0538.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
turnip vein clearing virus (TVCV); tobacco mosaic virus (TMV); tobamovirus; enzyme nanocarrier; protein A; antibody; enzyme cascade; glucose oxidase (GOx); horseradish peroxidase (HRP); biosensor
Online: 7 August 2023 (12:23:31 CEST)
REVIEW
|
doi:10.20944/preprints202307.1198.v1
Subject:
Medicine And Pharmacology,
Cardiac And Cardiovascular Systems
Keywords:
myocarditis; sudden death; chest pain; autopsy; necropsy; COVID-19; COVID-19 vaccines; mRNA; SARS-CoV-2 vaccination; death; excess mortality; spike protein; organ system
Online: 18 July 2023 (09:34:51 CEST)
REVIEW
|
doi:10.20944/preprints202304.0973.v1
Subject:
Biology And Life Sciences,
Neuroscience And Neurology
Keywords:
vitamin B1; vitamin B6; vitamin B3; pyridoxal-5’-phosphate; thiamine diphosphate; NAD+, mutation in vitamin-binding protein; Charcot-Marie-Tooth disease; DHTKD1; PDK3; PDXK
Online: 26 April 2023 (08:33:26 CEST)
ARTICLE
|
doi:10.20944/preprints202105.0694.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
Congenital hypothyroidism; FOXE1; Mexican population; multiplex ligation-dependent probe amplification (MLPA); NKX2-1; NKX2-5; PAX8; polyalanine tract; protein modeling; thyroid dysgenesis; TSH receptor
Online: 28 May 2021 (11:15:14 CEST)
REVIEW
|
doi:10.20944/preprints202406.2068.v1
Subject:
Biology And Life Sciences,
Neuroscience And Neurology
Keywords:
spinal muscular atrophy (SMA); survival of motor neuron 1 (SMN1); SMN2; SMN protein; antisense oligonucleotide (ASO); nusinersen; gene therapy; onasemnogene; risdiplam; small molecule; combination therapy
Online: 29 June 2024 (06:33:01 CEST)
ARTICLE
|
doi:10.20944/preprints202401.1988.v1
Subject:
Medicine And Pharmacology,
Clinical Medicine
Keywords:
severe traumatic brain injury; regulatory T cell; forkhead box protein 3; T helper 17; retinoic acid receptor-related orphan receptor gamma t; gut microbiome; probiotic
Online: 29 January 2024 (08:51:54 CET)
ARTICLE
|
doi:10.20944/preprints202306.0366.v1
Subject:
Biology And Life Sciences,
Plant Sciences
Keywords:
Liquid liquid phase separation; protein oligomerization; GO; domain-domain interaction; domain linker; intrinsically disordered regions; domain-peptide interaction; beta-sheet; transmembrane helices; post-translational modification
Online: 6 June 2023 (03:43:57 CEST)
ARTICLE
|
doi:10.20944/preprints202305.0276.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
fibroblast activation protein α (FAP-α); cancer-associated fibroblasts (CAFs); FAP inhibitors (FAPIs); PET imaging; gallium-68; (R)-pyrrolidin-2-yl-boronic acid-based radiopharmaceuticals
Online: 5 May 2023 (02:40:01 CEST)
REVIEW
|
doi:10.20944/preprints202106.0337.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
alcohol use disorders (AUD); cancer, ethanol oxidative and nonoxidative metabolism, acetaldehyde, reactive oxygen species (ROS), DNA adducts, protein damage, cancer stem cells (CSC), epigenetic changes.
Online: 14 June 2021 (09:03:43 CEST)
REVIEW
|
doi:10.20944/preprints202002.0031.v1
Subject:
Chemistry And Materials Science,
Electrochemistry
Keywords:
direct-electron transfer-type bioelectrocatalysis; nanostructures; mesoporous electrodes, curvature effect; protein engineering; bi-directional bioelectrocatalysis; hydrogenase; fructose dehydrogenase; bilirubin oxidase; formate dehydrogenase; ferredoxin-NADP+ reductase
Online: 3 February 2020 (13:34:02 CET)
ARTICLE
|
doi:10.20944/preprints201812.0293.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
human poly(ADP-ribose) polymerase 1 (PARP1), PARP-DNA complex,DNA-protein binding,DNA repair, 5′,8-Cyclopurine-2′-deoxynucleoside, DNA damage , DNA repair efficiency.
Online: 24 December 2018 (16:01:44 CET)
ARTICLE
|
doi:10.20944/preprints201812.0236.v2
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
bacterial toxin; cholera toxin; Escherichia coli heat-labile enterotoxin; lectin; N-acetyllactosamine binding; neutral glycosphingolipids; protein-carbohydrate interactions; surface plasmon resonance spectroscopy; X-ray crystal structure
Online: 28 January 2019 (15:23:24 CET)
REVIEW
|
doi:10.20944/preprints201811.0389.v1
Subject:
Medicine And Pharmacology,
Cardiac And Cardiovascular Systems
Keywords:
adverse remodeling; aldosterone; cardiac myocyte; crosstalk; G protein-coupled receptor (GPCR); GPCR-kinase (GRK); heart failure; inflammation; mineralocorticoid receptor; myocardial infarction; oxidative stress; signal transduction
Online: 16 November 2018 (07:54:04 CET)
ARTICLE
|
doi:10.20944/preprints201804.0278.v1
Subject:
Medicine And Pharmacology,
Pediatrics, Perinatology And Child Health
Keywords:
monocyte chemoattractant protein-1; MCP-1; C-C motif chemokine ligand 2; CCL2; childhood asthma; bronchial asthma; severe asthma; cystic fibrosis; chronic obstructive pulmonary disease
Online: 23 April 2018 (09:00:00 CEST)
REVIEW
|
doi:10.20944/preprints202306.0329.v1
Subject:
Medicine And Pharmacology,
Cardiac And Cardiovascular Systems
Keywords:
SARS-CoV-2 vaccine side effect; vaccines and Heart rhythm disorders; Spike Protein and cardiac arrhythmias; ACE system and heart conduction; Angiotensin II and cardiac arrhythmias
Online: 5 June 2023 (13:40:58 CEST)
REVIEW
|
doi:10.20944/preprints202305.0503.v1
Subject:
Biology And Life Sciences,
Biophysics
Keywords:
RNP assembly; ribosome assembly; protein-RNA interactions; RNA folding; assembly intermediates; in vitro reconstitutions; mass spectrometry; single-molecule fluorescence microscopy; cryo-electron microscopy; RNA structure probing
Online: 8 May 2023 (10:01:55 CEST)
COMMUNICATION
|
doi:10.20944/preprints202106.0091.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
COVID-19; SARS-CoV-2 variant; lateral flow immunoassay; spike protein; receptor binding domain (RBD); neutralizing antibody; therapeutic antibody cocktail; epitope binning; rapid neutralization test; ACE2
Online: 2 June 2021 (16:11:29 CEST)
ARTICLE
|
doi:10.20944/preprints202105.0648.v1
Subject:
Biology And Life Sciences,
Anatomy And Physiology
Keywords:
herpes simplex virus type 1 (HSV-1); bovine herpesvirus 1 (BoHV-1); Krüppel–like factor 15 (KLF15); infected cell protein 0 (ICP0); BoHV-1 ICP0 (bICP0)
Online: 26 May 2021 (15:10:59 CEST)
CONCEPT PAPER
|
doi:10.20944/preprints202005.0182.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
Coronavirus Nsp proteins; ribosomal proteins homology; inhibition of ribosome turn over; rRNA methyltransferase; protein synthesis inhibition; low ATP formation; blood clotting; low blood pressure and coma
Online: 10 May 2020 (18:14:55 CEST)
REVIEW
|
doi:10.20944/preprints201912.0040.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
unfolded protein response (UPR); integrated stress response (ISR); ATF6; IRE1; XBP1; PERK; ATF4; GADD34; herpesvirus; Kaposi’s sarcoma-associated herpesvirus (KSHV); cytomegalovirus (CMV); herpes simplex virus (HSV)
Online: 4 December 2019 (04:38:02 CET)
ARTICLE
|
doi:10.20944/preprints202407.2267.v1
Subject:
Chemistry And Materials Science,
Applied Chemistry
Keywords:
colorimetric DNA detection; lateral flow assay; nitrocellulose membranes; StructSure Membranes; DNA for diagnostics; multiplexing; nucleic acid lateral flow assay (NALFA); protein-free; amplification-free; body-fluid identification
Online: 29 July 2024 (08:50:25 CEST)
ARTICLE
|
doi:10.20944/preprints202401.1916.v1
Subject:
Biology And Life Sciences,
Life Sciences
Keywords:
Breast Cancer; Triple negative breast cancer; T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3); HAVCR-2; TCGA; BRCA; TIMER2.0; UALCAN; GEPIA
Online: 29 January 2024 (02:11:05 CET)
REVIEW
|
doi:10.20944/preprints202401.1046.v1
Subject:
Biology And Life Sciences,
Ecology, Evolution, Behavior And Systematics
Keywords:
aminoacyl-tRNA synthetase• tRNA cognate pairs; bidirectional genetic coding; protein folding and gating; origin of catalysis; origin of free energy transduction; genome propagation into the proteome
Online: 15 January 2024 (10:26:46 CET)
ARTICLE
|
doi:10.20944/preprints202301.0454.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
cell stress response; heat shock protein 90 (HSP90); SCAN domain-containing proteins (SCAND); MZF1; heat shock factors (HSF); co-expression correlation; Kaplan-Meyer analysis; cancer patients prognosis
Online: 25 January 2023 (10:18:20 CET)
ARTICLE
|
doi:10.20944/preprints202301.0340.v1
Subject:
Biology And Life Sciences,
Food Science And Technology
Keywords:
alternative food; resilient food; distributed production; edible plants; existential risk; food security; global catastrophic risk; leaf concentrate; leaf protein; non-target screening; resilience; sustainable food systems; toxins
Online: 19 January 2023 (01:57:51 CET)
ARTICLE
|
doi:10.20944/preprints202109.0415.v2
Subject:
Biology And Life Sciences,
Virology
Keywords:
Delta variant; Variants of concern; Variants of interest; SARS-CoV-2; Spike protein; Nested RT-PCR; Sanger sequencing; Amino acid mutations; ACE2 RBD; N-terminal domain (NTD)
Online: 2 November 2021 (10:40:46 CET)
REVIEW
|
doi:10.20944/preprints201912.0386.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
resistance-associated secretory phenotype (RASP); extracellular vesicle (EV); exosome; oncosome; drug resistance; epithelial-mesenchymal transition (EMT); heat shock protein (HSP); cell stress response; hypoxia; acidosis; tumor immunology
Online: 29 December 2019 (13:46:21 CET)
REVIEW
|
doi:10.20944/preprints202401.1443.v1
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
The Blood-Brain Barrier (BBB); CNS drug discovery; passive diffusion; active transport; Efflux transporters; Influx Transporters; P-glycoproteins (P-gp); breast cancer resistance protein (BCRP); in silico models
Online: 19 January 2024 (09:32:31 CET)
ARTICLE
|
doi:10.20944/preprints202302.0347.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Pomegranate; separation of varieties by taste; degree of maturity; fruit weight and ratio of its in-dividual parts; chemical composition; sugar; protein; ascorbic acid; common polyphenols; flavo-noids
Online: 21 February 2023 (02:08:54 CET)
REVIEW
|
doi:10.20944/preprints201912.0412.v2
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Frank-Starling; angiotensin receptor; muscle contraction; myosin light chain kinase; Protein Kinase C-βII; myosin light chain phosphatase; β-arrestin; MgATP; MgADP-phosphomyosin; myosin LC affinity for Ca2+
Online: 11 January 2020 (13:24:08 CET)
REVIEW
|
doi:10.20944/preprints201805.0413.v1
Subject:
Biology And Life Sciences,
Biophysics
Keywords:
silver nanoparticles; nanosilver; endocytosis; oxidative stress; reactive oxygen species; inflammation; wound healing; hypoxia; mitochondria; endoplasmic reticulum stress; unfolded protein response; autophagy; apoptosis; angiogenesis; epigenetics; genotoxicity; cancer; anti-cancer
Online: 28 May 2018 (15:51:12 CEST)
ARTICLE
|
doi:10.20944/preprints201612.0068.v2
Subject:
Biology And Life Sciences,
Cell And Developmental Biology
Keywords:
modulation of nuclear gene expression; mitochondrial 18 kDa translocator protein (TSPO); TSPO ligand; PK 11195; 2-Cl-MGV-1; retrograde mitochondrial-nuclear signaling pathway; microscopy; mitochondria; cell nucleus
Online: 17 March 2017 (17:28:28 CET)
ARTICLE
|
doi:10.20944/preprints202403.0727.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
oral/gingival epithelium; environmental hypotonic stress; interferon-λ; human myxovirus re-sistance protein (MxA); biomolecular condensates; membraneless organelles (MLOs); osmoreg-ulation; macromolecular uncrowding and recrowding; regulated volume decrease (RVD)
Online: 12 March 2024 (15:23:39 CET)