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Preprint ARTICLE | doi:10.20944/preprints202110.0330.v1

First Observations of SN 1604 (Kepler's Supernova)

Alessandro De Angelis, selenia broccio

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Supernova remnants; Stellar evolution; High-energy astrophysics

Online: 22 October 2021 (12:11:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0426.v1

Magnetic Field Alignment, a Perspective in the Engineering of Collagen-Silica Composite Biomaterials

Nicolas Debons, Kenta Matsumoto, Noriyuki Hirota, Thibaud Coradin, Toshiyuki Ikoma, Carole Aimé

Subject: Chemistry And Materials Science, Biomaterials Keywords: bionanocomposites; collagen; high magnetic field; silica particles

Online: 15 April 2021 (18:12:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0122.v1

Performance Enhancement Techniques for Patch Antennas of Small Satellites

Zizung Yoon, Mayank Mayank, Enrico Stoll

Subject: Engineering, Electrical And Electronic Engineering Keywords: satellite communication, antenna optimization, high gain antenna

Online: 3 March 2021 (09:59:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0104.v1

Chitosan from crabs (Scylla Serrata) Represses Hepato-renal Dysfunctions in Rats via Modulation of CD43 and p53 Expression in High Fat Diet-induced Hyperlipidemia

Regina Ngozi Ugbaja, Kunle Ogungbemi, Adewale Segun James, Peter Folorunsho Ayodele, Olanrewaju Samuel Abolade, Stella Ajamikoko, Eniola Olapeju Atayese, Omowunmi Victoria Adedeji

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Chitosan; Hyperlipidemia; High-fat diet; p53; CD43

Online: 2 March 2021 (16:02:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0550.v1

Optical Data Transmission at 44 Tb/s with a Single Integrated Chip Source

Mengxi Tan, Mike Xu, David Moss

Subject: Engineering, Telecommunications Keywords: microcombs; data transmission; filters; high bandwidth; optical

Online: 24 February 2021 (12:59:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0507.v1

Optical Frequency Microcomb Distillation for Super Channel Data Transmission

Chawaphon Prayoonyong, Andreas Boes, Xingyuan Xu, Mengxi Tan, Sai T. Chu, Brent E. Little, Roberto Morandotti, Arnan Mitchell, David J. Moss, Bill Corcoran

Subject: Engineering, Automotive Engineering Keywords: microcombs, data transmission, filters, high bandwidth, optical

Online: 23 February 2021 (09:49:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0333.v1

ATmospheric LIDar (ATLID): European Space Agency Instrument Ready to Measure Aerosols and Thin Clouds in Atmosphere

João Pereira do Carmo, Geraud de Villele, Kotska Wallace, Alain Lefebvre, Kaustav Ghose, Thomas Kanitz, François Chassat, Bertrand Corselle, Thomas Belhadj, Paolo Bravetti

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: LIDAR; UV laser; high spectral resolution; aerosols

Online: 14 December 2020 (13:11:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202006.0111.v1

A Novel Family of Quadrupole-Orbitrap Mass Spectrometers for a Broad Range of Analytical Applications

Jan-Peter Hauschild, Amelia Corinne Peterson, Erik Couzijn, Eduard Denisov, Denis Chernyshev, Christian Hock, Hamish Stewart, Ralf Hartmer, Dmitry Grinfeld, Christian Thoeing, Bastian Reitemeier, Arne Kreutzmann, Oliver Lange, Wilko Balschun, Aivaras Venckus, Sebastian Kanngiesser, Alexander Kholomeev, Gregor Quiring, Frank Czemper, Eloy Wouters, Michael Belford, Mathias Mueller, Jens Grote, Tabiwang N. Arrey, Julia Kraegenbring, Kerstin Strupat, Siegrun Mohring, Catharina Crone, Alexander Harder, Aaron Robitaille, Aaron Gajadhar, Khatereh Motamed, Yang Liu, Daniel Lopez Ferrer, Nicolaie Eugen Damoc, Angela Criscuolo, Kristina Srzentic, Ed George, Charles Yang, Ioanna Ntai, Amanda Souza, Andreas Wieghaus, Alexander Makarov

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Orbitrap mass spectrometry; high resolution; accurate mass

Online: 8 June 2020 (10:17:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0459.v1

Oxidation and Characterization of Low Concentration Gas in High-Temperature Reactor

Jinhua Chen, Guangcai Wen, Song Yan, Xiangyun Lan, Lu Xiao

Subject: Engineering, Energy And Fuel Technology Keywords: low concentration; gas; reactor; high-temperature oxidation

Online: 29 February 2020 (09:20:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints201910.0137.v1

An Efficient and High-Resolution Topology Optimization Method Based on Convolutional Neural Networks

Liang Xue, Jie Liu, Guilin Wen, Hongxin Wang

Subject: Computer Science And Mathematics, Mathematics Keywords: topology optimization; convolutional neural network; high-resolution

Online: 12 October 2019 (03:56:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201903.0126.v4

Developing Bid-Ask Probabilities for High-Frequency Trading

Lester Ingber

Subject: Physical Sciences, Applied Physics Keywords: path integral; financial markets; high-frequency trading

Online: 8 May 2019 (08:47:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0238.v1

Assessment of Residual Feed Intake and Its Relevant Measurements in Two Varieties of Japanese Quail (Coturnix coturnix japonica) under High Environmental Temperature

Moataz M. Fathi, Ibrahim Al-Homidan, Tarek A. Ebeid, Ahmed Galal, Osama K. Abou-Emera

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: residual feed consumption; quail; high environmental temperature

Online: 22 April 2019 (11:22:21 CEST)

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Preprint REVIEW | doi:10.20944/preprints201806.0308.v1

Irradiance Variability Quantification and Small-Scale Averaging in Space and Time: A Short Review

Gerald M. Lohmann

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: irradiance variability, high-resolution measurements, increment statistics

Online: 19 June 2018 (17:10:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0075.v1

High Frequency Acceleration Device Effect on Accelerated Aligner Exchange - A Pilot Study

Thomas Shipley

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: high frequency; acceleration; vibration; orthodontics; tooth movement

Online: 6 April 2018 (10:57:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1708.v1

High-Entropy Diborides – Silicon Carbide Composites by Reactive and Non-reactive Spark Plasma Sintering: A Comparative Study

Ekaterina Pakhomova, Giacomo Cao, Roberto Orrù, Sebastiano Garroni, Paolo Ferro, Roberta Licheri

Subject: Chemistry And Materials Science, Ceramics And Composites Keywords: high-entropy borides; silicon carbide; spark plasma sintering; self-propagating high-temperature synthesis; resistance to oxidation; fracture toughness

Online: 22 December 2023 (07:11:43 CET)

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Working Paper ARTICLE

On the Influence of Control Type and Strain Rate on the Lifetime of 50CrMo4

Max Benedikt Geilen, Josef Arthur Schönherr, Marcus Klein, Dominik Sebastian Leininger, Alexander Giertler, Ulrich Krupp, Matthias Oechsner

Subject: Chemistry And Materials Science, Biomaterials Keywords: ultrasonic cyclic testing; frequency effect; strain rate effect; 50CrMo4; SAE 4150; High Cycle Fatigue; Very High Cycle Fatigue

Online: 21 October 2020 (15:18:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202010.0051.v1

ROS and NO Regulation by Melatonin Under Abiotic Stress in Plants

Miriam Pardo-Hernandez, Maria Lopez-Delacalle, Rosa M Rivero

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: melatonin; ROS; NO; posttranslational modifications (PMTs); abiotic stress; drought; salinity; high temperature; high light; waterlogging; abiotic stress combination

Online: 5 October 2020 (07:48:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0655.v1

Study on the Equivalent Density Tool and Depressurization Mechanism of Suction-Type Depressurization Cycle

Meipeng Ren, Xingquan Zhang, Renjun Xie, Junyan Wang, Zhaopeng Zhu, 学彬程, Liangbin Dou

Subject: Engineering, Other Keywords: Cyclic equivalent density (ECD); Annular pressure reduction; depressurization tools; Suction-type ECD reduction tool; High temperature and high pressure

Online: 8 July 2024 (14:17:02 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202404.0833.v1

Convenient Preparation, Thermal Properties and X-Ray Structure Determination of 2,3-Dihydro-5,6,7,8-tetranitro-1,4-benzodioxine (TNBD): a Promising High Energy Density Material (HEDM)

Jonas Šarlauskas

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: 1,4-benzodioxane; nitration; nitro derivatives; tetranitro; synthesis; X-ray crystallography; structure; thermal analysis; high energy high density material (HEDM)

Online: 12 April 2024 (08:03:59 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0669.v1

The Possibility of a High-efficiency Wave Power Generation System using Dielectric Elastomers

Seiki Chiba, Mikio Waki, Changqing Jiang, Makoto Takeshita, Mitsugu Uejima, Kohei Arakawa, Kazuhiro Ohyama

Subject: Engineering, Automotive Engineering Keywords: dielectric elastomer; generation; carbon dioxide free; rare earths free; high efficiency; CNT; high power; artificial muscle; actuator; large deformation

Online: 26 April 2021 (13:09:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0622.v1

Influence of Preheating Temperature on Hardness and Microstructure of PBF Steel hs6-5-3-8

Jasmin Saewe, Markus Benjamin Wilms, Lucas Jauer, Johannes Schleifenbaum

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: LPBF; Laser Powder Bed Fusion; SLM; Selective Laser Melting; High-speed steel; tool steel; high carbon content; preheating temperature

Online: 29 January 2021 (13:09:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202411.0099.v1

High-performance PZT Piezoelectric Ceramic Materials for Photocuring 3D Printing

Weiwei Gao, Ze Xu, Ke Wang

Subject: Chemistry And Materials Science, Ceramics And Composites Keywords: Piezoelectric ceramic; Photocuring; 3D printing; High-performance; PZT

Online: 1 November 2024 (18:34:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202410.1377.v1

Response of Chlorophyllase and Magnesium Dechelatase Enzymes in Yellow and Green‐Fleshed Kiwifruit to Degreening at Different Temperatures

Angeli Labra, Juan Pablo Zoffoli.

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: flesh color; enzyme activity; high temperature; chlorophyll breakdown

Online: 17 October 2024 (10:33:29 CEST)

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The kiwifruit cultivars include fruit having a diversity of flesh colors in the range red to yellow to green, associated with specific pigment accumulations. In the yellow-fleshed cultivars, chlorophyll degradation is necessary to unmask the underlying carotenoid pigments, which are responsible for the yellow color. This study aimed to conform the enzymatic activity involved in chlorophyll degradation using different degreening temperatures in the yellow-fleshed kiwifruit (cv. ‘Kiss,’ Actinidia chinensis var. chinensis) and in the contrasting green-flesh kiwifruit (cv. ‘Hayward’, Actinidia chinensis var. deliciosa). ‘Kiss’ was harvested at hue angle 106.9 ° and degreening was carried out at 0, 5, 10 or 15 °C for 41 d. Additionally, one week later, a second batch of kiwifruit was subsequently treated at 30 °C for one week to explore the inhibitory effect on degreening and to elucidate the roles of chlorophyllase and magnesium dechelatase enzymes in the process. Fruit degreened at 30 °C was maintained at 15°C for 23 d afterward and was compared with fruit stored at 0 °C or at 15 °C for 30 d. Similar degreening treatments were applied to cv. ‘Hayward’ at commercial maturity. Every seven days, flesh color, pigment concentrations and the activities of chlorophyllase and magnesium dechelatase in the flesh were evaluated. Degreening of ‘Kiss’ kiwifruit was enhanced by the 15 °C treatment or by 30 °C treatment for seven days and was associated with increasing of carotenoids and decreasing of chlorophyll a. The magnesium dechelatase activity was greater in fruit degreening at 15°C, which was consistently maintained throughout the degreening period; however, the activity remained low at very high temperature (30 °C). Regardless of the above, degreening at 30 °C was not inhibited, showing faster color change and high chlorophyllase activity during the exposure time. In contrast, ‘Hayward’ maintained its green color with high concentrations of the chlorophylls and carotenoids. However, the high chlorophyllase and the low magnesium dechelatase activities found in ‘Hayward’, suggest the chlorophyllase enzymes are not the only ones involved in flesh degreening.

Preprint ARTICLE | doi:10.20944/preprints202410.0629.v1

Intercity Rail Fares After HSR Liberalization in Spain: The Madrid-Barcelona Corridor

Santiago García-Samaniego, Javier Campos

Subject: Business, Economics And Management, Economics Keywords: high-speed rail (HSR); rail fares; liberalization; Spain

Online: 9 October 2024 (14:39:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.0135.v1

The Effect of an Anisotropic Scattering Rate on the Magnetoresistance of a Metal: A Cuprate-Inspired Analysis

Giovanni Mirarchi, Sergio Caprara

Subject: Physical Sciences, Condensed Matter Physics Keywords: Magnetoresistance; anomalous metals; high-critical-temperature superconducting cuprates

Online: 2 October 2024 (11:08:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.2005.v1

Research Progress on CoCrCuNi High-Entropy Alloys

Fachang Zhao, Xingming Zhao, Tianzhi Jiang, Honglin Li, Xue Liu, Ziqing Ai, Rongda Zhao, Fufa Wu

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: high-entropy alloys; CoCrCuNi system; microstructure; mechanical properties

Online: 25 September 2024 (17:59:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0179.v1

In-Situ Microstructural Evolution and Precipitate Analysis of High-Nickel Shipbuilding Steel Using High Temperature Confocal Laser Scanning Microscopy

Guojin Sun, Zhenggui Li, Qi Wang

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: HTCLSM; Microstructural evolution; Thermal processing; High-nickel steel

Online: 5 August 2024 (05:14:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0538.v1

External Load Evaluation in Elite Futsal: Influence of Match Results and Game Location with IMU Technology

Héctor Gadea Uribarri, Carlos Lago-Fuentes, Ainhoa Bores-Arce, Victor Emilio Villavicencio Álvarez, Sergio López-García, Santiago Calero-Morales, Elena Mainer-Pardos

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: load monitoring; home-advantage; high performance; team sports

Online: 5 July 2024 (13:47:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.1150.v1

An Examination of the Very First Polarimetric X-ray Observations of Radio-quiet Active Galactic Nuclei

Frédéric Marin, Vittoria Elvezia Gianolli, Adam Ingram, Dawoon E Kim, Andrea Marinucci, Daniele Tagliacozzo, Francesco Ursini

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: X-ray polarization; high-energy processes; black holes

Online: 17 June 2024 (14:45:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0818.v1

Dynamic Analysis of Stool Microbiota of Simmental Calves and Effects of Diarrhea on Their Gut Microbiota

Qianxun Wang, Mula Na, Shiyu Jia, Miao Sun, Song Gao, Shiwei Pan, Wu Dong, Yang Song, Jingfeng Yang

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Calf diarrhea; Intestinal flora; High throughput 16S rRNA

Online: 12 June 2024 (09:39:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.2137.v1

Cross-Species Transmission of Highly Pathogenic Avian Influenza (HPAI) H5N1 Virus in the U.S. Dairy Cattle: A Comprehensive Review

Chithra C. Sreenivasan, Feng Li, Dan Wang

Subject: Biology And Life Sciences, Virology Keywords: high pathogenic avian influenza (HPAI); H5N1; cattle; transmission

Online: 31 May 2024 (12:19:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1669.v1

Shock Absorption Capacity of High-Performance Polymers for Dental Implant Prosthesis: In Vitro Study

Maria Menini, Francesca Delucchi, Francesco Bagnasco, Domenico Baldi, Luigi Canullo, Paolo Setti, Marco Migliorati, Paolo Pesce

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: dental implants; shock absorption; high-performance polymers; polyetherketoneketone

Online: 23 January 2024 (10:00:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1679.v1

Two Novel Betarhabdovirids Infecting Ornamental Plants and the Peculiar Intracellular Behavior of the Cytorhabdovirus in the Liana Aristolochia gibertii

Pedro Luis Ramos-González, Maria Amelia Vaz Alexandre, Matheus Potsclam-Barro, Lígia Maria Lembo Duarte, Gianluca L. Michea Gonzalez, Camila Chabi-Jesus, Alyne F. Ramos, Ricardo Harakava, Harri Lorenzi, Juliana Freitas-Astúa, Elliot Watanabe Kitajima

Subject: Biology And Life Sciences, Virology Keywords: rhabdovirus; betanucleorhabdovirus; high-throughput sequencing; virion particles; cytopathology

Online: 23 January 2024 (09:50:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1599.v1

High-Gravity Brewing of Bohemian Lager with Wheat Adjuncts

Tomáš Kinčl, Pavel Dostálek, Jana Olšovská, Rudolf Jung

Subject: Biology And Life Sciences, Food Science And Technology Keywords: beer; high-gravity brewing; wheat adjuncts; foam; flavour

Online: 23 January 2024 (00:10:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0634.v1

Effects of Different Temperature and Density on Quality and Microbial Population of Alfalfa Silage

Jingyi Liu, Junfeng Hao, Muqier Zhao, Xingquan Yan, Gentu Ge

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: High temperature ensiling; Density; Microbial community; Fermentation quality

Online: 9 January 2024 (02:51:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0188.v1

A Novel High Isolation Orthogonally CPW-Fed UWB MIMO Antenna for Future IoT Applications

Muhammad Zahid, Nirman Bhowmike, Zaeem Mazhar, Asma Ejaz, Sultan Shoaib, Yasar Amin

Subject: Engineering, Electrical And Electronic Engineering Keywords: CPW; UWB; MIMO; Internet of things; high isolation

Online: 4 January 2024 (03:29:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.2312.v1

Spatial and Temporal Dynamics of the Vegetation Cover from the Bijagual Massif, Boyacá, Colombia, during the 1986–2021 Period

Pablo Andrés Gil-Leguizamón, Jaime Francisco Pereña-Ortiz, Daniel Sánchez-Mata, Ángel Enrique Salvo-Tierra, Jorge David Mercado-Gómez, And María Eugenia Morales-Puentes

Subject: Environmental And Earth Sciences, Ecology Keywords: high Andean forest; Landsat; landscape metrics; multitemporality; paramo

Online: 29 December 2023 (14:33:48 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.1398.v1

Optimal Conditions for Generation of Runaway Electrons in High Pressure Gases

Victor Tarasenko

Subject: Physical Sciences, Fluids And Plasmas Physics Keywords: runaway electrons; diffuse discharge; high pressure; electron beams

Online: 19 December 2023 (07:11:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1084.v1

Discharge Coefficients of Standard Spillways at High Altitudes

Víctor Rendón, Martí Sánchez-Juny, Soledad Estrella, Marcos Sanz-Ramos, Percy Rucano, Alan Huarca Pulcha

Subject: Engineering, Civil Engineering Keywords: Ogee profile; discharge coefficients; atmospheric pressure; high altitude

Online: 14 December 2023 (12:13:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1822.v1

MicroAnnot: A Dedicated Workflow for Accurate Microsporidian Genome Annotation

Jérémy Tournayre, Valérie Polonais, Ivan Wawrzyniak, Reginald Florian Akossi, Nicolas Parisot, Emmanuelle Lerat, Fréréric Delbac, Pierre Souvignet, Matthieu Reichstadt, Eric Peyretaillade

Subject: Biology And Life Sciences, Parasitology Keywords: Microsporidia, Structural annotation, dedicated workflow, high quality annotation.

Online: 30 October 2023 (06:25:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1281.v1

Effects of ESC/ESH-Based Written Lifestyle Advice including a Nutraceutical on 24-Hour Blood Pressure in High-Normal Blood Pressure Patients with Low Cardiovascular Risk

Matteo Landolfo, Francesco Spannella, Chiara Poliseno, Adriano Massacesi, Federico Giulietti, Roberto Festa, Enrico Cavazzin, Giulio Sasso, Alberto Mazza, Riccardo Sarzani

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: high-normal BP; hypertension; lifestyle; nutraceuticals; nitrates; beetroot

Online: 20 October 2023 (08:07:43 CEST)

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(1) Background: Lifestyle changes, eventually associated with a nutraceutical, are recommended strategies for managing high-normal blood pressure (BP) patients with low-moderate cardiovascu-lar (CV) risk. Nitrates-enriched products (i.e., red beet extracts) may help reduce BP, exerting vas-oactive properties and enhancing adherence to lifestyle advice. Our study aimed to evaluate the effectiveness in clinical practice of generic written lifestyle advice and a beetroot-based nutraceu-tical prescription based on the 2018 ESC/ESH guidelines on 24-hour BP in a population with high-normal BP and low-moderate CV risk.; (2) Methods: A longitudinal observational study was con-ducted in two ESH hypertension excellence centres on 43 consecutive subjects with high-normal BP based on repeated office BP (OBP) measurements and a low-moderate CV risk. Twenty-four-hour ambulatory BP monitoring (ABPM) was carried out at baseline and three months after ge-neric written ESC/ESH advice for lifestyle changes associated with a nutraceutical containing 500 mg of dry beetroot extract; (3) Results: Mean age 50±11 years, 54% males, 58% overweight/obese, mean OBP 135±3/85±3 mmHg. At baseline, 24-hour BP, daytime BP and night-time BP were 127±7/80±6 mmHg, 131±8/83±6 mmHg and 118±8/70±5 mmHg, respectively, BP profiles compat-ible with hypertension status in some subjects. After a median follow-up of 98 (92-121) days, all BPs, except night-time diastolic BP, were significantly decreased: -3±6/-2±4 mmHg for 24-hour BP, -3.9±6.0/-3.0±4.0 mmHg for daytime BP and -3.3±7.4/-1.3±4.7 mmHg for night-time BP, respec-tively. No significant clinical changes in weight were detected. BP decreased independently of baseline BP level, gender, smoking status and BMI, while a more substantial decrease in BP was observed in older patients; (4) Conclusions: Our pilot study shows for the first time that written generic lifestyle advice based on ESC/ESH hypertension guidelines coupled with a beetroot-based nutraceutical may represent a valid initial non-pharmacological approach in subjects with high-normal BP and low-moderate CV risk even without personalized diet interventions.

Preprint ARTICLE | doi:10.20944/preprints202310.0659.v1

High-Level Architecture for Interoperable Digital Twins

Mamadou Kaba Traoré

Subject: Computer Science And Mathematics, Computer Science Keywords: Digital Twin; Smart City; Interoperability; High-Level Architecture

Online: 11 October 2023 (03:32:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0544.v1

Multi-Omics Data Integration Reveals Sex-Dependent Hippocampal Programming by Maternal High-Fat Diet during Lactation in Adult Mouse Offspring

Thibaut Gauvrit, Hamza Benderradji, Alexandre Pelletier, Soulaimane Aboulouard, Emilie Faivre, Kevin Carvalho, Aude Deleau, Emmanuelle Vallez, Agathe Launay, Anna Bogdanova, Mélanie Besegher, Stéphanie Le Gras, Anne Tailleux, Michel Salzet, Luc Buée, Fabien Delahaye, David Blum, Didier Vieau

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Maternal high-fat diet; multiomics; sexual dimorphism; hippocampus

Online: 9 October 2023 (13:18:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0352.v1

Evaluation of Cell Rupture Techniques on the Extraction of Proteins from Microalgae Tetradesmus obliquus

César Augusto Sodré da Silva, Karen Vanessa Marimón Sibaja, Sabrina de Ramos Cizilio, José Roberto Miranda Júnior, Rejane de Castro Santana, Marcio Arêdes Martins, Maurício de Oliveira Leite, Eduardo Basílio de Oliveira, Jane Sélia dos Reis Coimbra

Subject: Biology And Life Sciences, Food Science And Technology Keywords: ball milling; high-pressure homogenization; ultrasonication; cell counting

Online: 9 October 2023 (08:56:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1508.v1

Influence of Demagnetisation on Barkhausen Noise in the High-Strength Low-Alloyed Steel 1100 MC

Martin Pitoňák, Nikolaj Ganev, Katarína Zgútová, Jiří Čapek, Miroslav Neslušan, Karel Trojan

Subject: Engineering, Mechanical Engineering Keywords: high-strength steel; Barkhausen noise; surface heterogeneity; asymmetry

Online: 22 September 2023 (09:17:26 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202308.2067.v1

Discovery of the Mafic Granulites in the Muzhaerte area, SW Tianshan, China

Jun Yan, Ying Cui

Subject: Environmental And Earth Sciences, Geochemistry And Petrology Keywords: mafic granulites; Tianshan; Muzhaerte; high-temperature metamorphism; geothermobarometry

Online: 30 August 2023 (14:11:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0315.v1

Simulation Study on the Process of Cleaning Oily Sludge with High-speed Stirring Rotor

Yin Wang, Keqing Li, Jiao Zhao, Xiaojia Tang, Tie Li, Xianmeng Liu, Hao Zhang, Yimin Zhu

Subject: Environmental And Earth Sciences, Environmental Science Keywords: COMSOL Multiphysics; High-speed; Stirring rotor; Oily sludge

Online: 3 August 2023 (10:01:49 CEST)

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Preprint ESSAY | doi:10.20944/preprints202307.1367.v1

The Self-Confidence among Those with High Musical Abilities Student

Khalid Hammouri

Subject: Arts And Humanities, Music Keywords: self-confidence; music; musically talented; high musical abilities

Online: 20 July 2023 (04:57:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0523.v1

A Modified Guideline for High-Fidelity Patient Simulation to Improve Student Satisfaction and Self-Confidence in Learning: A Mixed Study

Florence M.F. Wong*, David C.N. Wong

Subject: Public Health And Healthcare, Nursing Keywords: High-fidelity; simulation; satisfaction; confidence; learning; nursing education

Online: 7 July 2023 (20:03:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0941.v1

Numerical Study of the Effect of High Gravity in Material Extrusion System and Polymer Characteristics during Filament Fabrication

Xin Jiang, Ryo Koike

Subject: Engineering, Mechanical Engineering Keywords: Additive manufacturing; High gravity; Numerical simulation; Material extrusion

Online: 13 June 2023 (13:50:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0359.v1

Modified Extended Lie Group Method for Hessenberg Differential Algebraic Equations with Index 3

Juan Tang, Jianguang Lu

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: Differential algebraic equations; Lie group; Hessenberg; High index

Online: 14 April 2023 (09:35:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0126.v1

A Scientometric Review of the Effect of Using High Tunnels on Crop Vigor and Quality

Megan Donovan, Jorge Ruiz-Menjivar, Timothy Coolong, Marilyn E. Swisher

Subject: Environmental And Earth Sciences, Environmental Science Keywords: high tunnel; protected structure; crop vigor; scientometric analysis

Online: 7 April 2023 (13:01:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0554.v1

Analysis of the Skyscraper Wind around High-Rise Buildings in Coastal Region, South Korea, during Typhoon 'Hinnamnor'

Jongyeong Kim, Yongju Kwon, Byeonggug Kang, Joowon Choi, Soonchul Kwon

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Field measurement; Typhoon; High-rise building; Strong wind

Online: 30 January 2023 (10:13:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0237.v1

Added Value of Aerosol Observations of the Future AOS High Spectral Resolution Lidar with Respect to a Classic Backscatter Spaceborne Lidar Measurements

Flavien Cornut, Laaziz El Amraoui, Juan Cuesta, Jérôme Blanc

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Atmospheric-Observing-System; Aerosol; High-Spectral-Resolution-lidar

Online: 13 December 2022 (09:51:59 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202207.0406.v1

Ultra-High-Performance Fiber-Reinforced Concrete: Fresh Properties

Shaker Qaidi

Subject: Engineering, Civil Engineering Keywords: Ultra-High-Performance Fiber-Reinforced Concrete; Fresh properties

Online: 26 July 2022 (10:50:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0018.v1

Suspended Water Droplet Confined Laser Shock Processing at Elevated Temperatures

Jian Liu, Xiaohan Zhang, Yali He, Zhe Zhao, Min Xia, Yaowu Hu

Subject: Physical Sciences, Applied Physics Keywords: Droplet; Laser shock; High temperatures; Dynamics; Focusing enhancement

Online: 4 April 2022 (12:02:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0458.v2

Multi-channel Precision Bias Source for Experiments on Quantum dots

yumei tang, kefu liu, haixing sun

Subject: Engineering, Electrical And Electronic Engineering Keywords: quantum dots; bias source; multi-channel; high precision

Online: 9 August 2021 (18:17:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0453.v1

High Temperature and High Hydrostatic Pressure Cultivation, Transfer, and Filtration Systems for Investigating Deep Marine Microorganisms

Gina Carole Oliver, Anaïs Cario, Karyn Lynne Rogers

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: high-pressure microbiology; deep biosphere; cultivation devices; decompression

Online: 17 April 2021 (08:46:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0290.v1

Dimensions of Creativity in Secondary School High-Ability Students

Núria Arís Redó, Mª Ángeles Millán Gutiérrez, José-Diego Vargas Cano

Subject: Business, Economics And Management, Accounting And Taxation Keywords: creativity; high ability; scientific creativity; secondary school students

Online: 12 April 2021 (12:34:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0077.v1

Agro-Industrial Avocado (Persea americana) Waste Biorefinery

Anthony Mora-Sandí, Abigail Ramírez-González, Luis Castillo-Henríquez, Mary Lopretti-Correa, José Roberto Vega-Baudrit

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: biorefinery; bioprocess; agro-industry; high-value products; Avocado

Online: 2 April 2021 (15:35:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0269.v1

Forecasting High-Frequency Financial Time Series: An Adaptive Learning Approach With the Order Book Data

Parley Ruogu Yang

Subject: Business, Economics And Management, Accounting And Taxation Keywords: forecasting methods; statistical learning; high-frequency order book

Online: 9 March 2021 (12:24:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0204.v1

Characterization of the Lipidome and Biophysical Properties of Membranes from High Five Insect Cells Expressing Mouse P-Glycoprotein

Maria João Moreno, Patrícia Alexandra Teles Martins, Eva Bernardino, Biebele Abel, Suresh Ambudkar

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Lipidome; High Five insect cells; Membrane proteins; Biomembranes

Online: 8 February 2021 (12:23:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0547.v1

The Potential Effect of Oral Bacterial Community in Melanophryniscus Admirabilis (Admirable Red-Belly Toads) Conservation

Michele Bertoni Mann, Janira Prischula, Ícaro Maia Santos de Castro, Juliana Mello Severo, Michelle Abadie, Thayná Mendes De Freitas Lima, Valentina Z. Caorsi, Márcio Borges-Martins, Jeverson Frazzon, Ana Paula Guedes Frazzon

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: high throughput sequencing; amphibian; bacteria; xenobiotic; anthropogenic action

Online: 22 December 2020 (09:54:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0322.v1

Multiscale Method for Solving High-order BVPs

Yingchao Zhang, Liangcai Mei, Yingzhen Lin

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Multiscale orthonormal basis; High-order BVPs; Convergence order;

Online: 15 October 2020 (11:55:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0121.v1

The Factors of Implementation Performance-Based Building Design on High Rise Residential Building in Indonesia

Sulfiah Dwi Astarini, Christiono Utomo

Subject: Engineering, Civil Engineering Keywords: performance-based building design; PBBD; high-rise residential.

Online: 7 July 2020 (09:46:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201903.0207.v3

Visual Light Leak in High-Frequency Electromagnetic Radiation Hole: A Photon-Electron Theory for Living Tissue for Explaining Myopia

Alex Lee

Subject: Medicine And Pharmacology, Ophthalmology Keywords: myopia,photon-electron theory,high-frequency electromagnetic radiation

Online: 12 June 2019 (12:31:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0292.v1

Is Perceived Exertion an Useful Indicator of Metabolic and Cardiovascular Response to Metabolic Conditioning of Functional-Fitness Session? A Randomized Controlled Trial

Ramires Alsamir Tibana, Nuno Manuel Frade de Sousa, Jonato Prestes, Dahan da Cunha Nascimento, Carlos Ernesto, Joao Henrique Falk Neto, Michael Kennedy, Fabrício Azevedo Voltarelli

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: CrossFit; high-intensity functional training; Extreme conditioning programs

Online: 24 May 2019 (11:36:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0084.v1

Thermal Expansion Model of Cement paste and Concrete Considering Micro-Structural Changes under Elevated Temperature

Jaesung Lee, Yunping Xi, Seungcho Yang

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Phase change; Composite, Thermal expansion; High temperature; Concrete

Online: 9 January 2019 (12:48:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0608.v1

A Microfluidic Spheroid Culture Device with a Concentration Gradient Generator for High-Throughput Screening of Drug Efficacy

Wanyoung Lim, Sungsu Park

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: spheroids; concentration gradient generator; drug screening; high-throughput

Online: 28 November 2018 (10:08:05 CET)

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Preprint REVIEW | doi:10.20944/preprints201810.0416.v2

Back to the Future? The Fallopian Tube, Precursor Escape and a Dualistic Model of High-Grade Serous Carcinogenesis

T. Rinda Soong, David Kolin, Nathan Teschan, Christopher Crum

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: BRCA, high grade serous carcinoma, fallopian tube, precursor,

Online: 24 October 2018 (10:55:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0557.v1

Effects of a 120Hz High-Frequency Acceleration Device on Orthodontic Discomfort

Jonathan Nicozisis, Gary Brigham, John Sparaga, Thomas Shipley

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: orthodontics clear aligner, pain; vibration, high-frequency, HFA

Online: 24 October 2018 (08:14:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0287.v1

High Pressure Photoreduction of CO₂: Effect of Catalyst Formulation, Hole Scavenger Addition and Operating Conditions

Elnaz Bahadori, Antonio Tripodi, Alberto Villa, Carlo Pirola, Laura Prati, Gianguido Ramis, Ilenia Rossetti

Subject: Engineering, Chemical Engineering Keywords: CO2 reduction; Photoreduction; Titania; Photocatalysis; High pressure photocatalysis

Online: 16 August 2018 (14:04:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0183.v1

The Structure of Ferroselite, FeSe₂, at Pressures Upto 46 GPa and Temperatures Down to 50 K: ASingle-Crystal Micro-Diffraction Analysis

Barbara Lavina, Robert T Downs, Stanislav Sinogeikin

Subject: Physical Sciences, Condensed Matter Physics Keywords: FeSe2; high pressure; low temperature; single crystal diffraction

Online: 12 June 2018 (10:25:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201711.0179.v2

Experimental Study on Methane Desorption from Lumpy Coal under the Action of Hydraulic and Thermal

Dong Zhao, Dayuan Li, Yulin Ma, Zengchao Feng, Yangsheng Zhao

Subject: Engineering, Energy And Fuel Technology Keywords: methane; desorption; hydraulic; thermal; high pressure water injection

Online: 10 May 2018 (08:22:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0025.v1

Techno-Economic Analysis of High-Pressure Metal Hydride Compressor Systems

Claudio Corgnale, Martin Sulic

Subject: Engineering, Energy And Fuel Technology Keywords: high pressure hydrogen; metal hydride-based high pressure compression; techno-economic analysis; Ti-based AB2 metal hydrides; mini-channel heat exchanger

Online: 4 June 2018 (09:36:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.1608.v1

Modeling Clustered DNA Damage By Ionizing Radiation Using Multinomial Damage Probabilities And Energy Imparted Spectra

Francis Cucinotta

Subject: Biology And Life Sciences, Biophysics Keywords: radiobiology; clustered DNA damage; radiation oncology; high LET radiation

Online: 21 October 2024 (13:41:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.0638.v1

Progress of the Oxidation at 1000°C of a Low–Mn High–Cr Cantor’s Alloy in Natural Air

Lyna Amrouche, Patrice Berthod

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: Modified Cantor alloy; Manganese; Chromium; High temperature; Oxidation progress

Online: 9 October 2024 (12:25:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1117.v1

Hydration and Mechanical Properties of High-Volume Fly ash Cement under Different Curing Temperatures

Young-Cheol Choi

Subject: Engineering, Civil Engineering Keywords: curing temperature; high volume fly ash; hydration; compressive strength

Online: 15 September 2024 (07:32:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1227.v1

Research on the Uplift Characteristics of Pantographs of High-Speed Trains Under Crosswind Conditions

Meng Zhao, Yaning Duan, Xingbo Lan, Zile Jia

Subject: Engineering, Transportation Science And Technology Keywords: high-speed train pantograph; crosswind; aerodynamic lift; transmission coefficient

Online: 19 August 2024 (04:39:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1171.v1

HE-DEPSO Algorithm for Textures Optimization with Application in Particle Physics

Emmanuel Martínez-Guerrero, Pedro Lagos Eulogio, Pedro Miranda-Romagnoli, Roberto Noriega-Papaqui, Juan Carlos Seck-Tuoh-Mora

Subject: Computer Science And Mathematics, Other Keywords: Optimization; High energy physics; Differential evolution; Particle swarm optimization

Online: 16 August 2024 (08:10:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2274.v1

BA-CLM: A Globally Consistent 3D LiDAR Mapping Based on BA Cost Factors

Bohan Shi, Wanbiao Lin, Wenlan Ouyang, Chenyu Shen, Siyang Sun, Yan Sun, Lei Sun

Subject: Engineering, Other Keywords: consistent high-precision mapping; LiDAR bundle adjustment; graph optimization

Online: 29 July 2024 (09:56:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1732.v1

A Novel Method for Online Diagnosis of Aging State of High-voltage (HV) Cables Based on Impedance Spectroscopy

Yuli Wang, Benhong Ouyang, Ge Wang, Anzhe Wang, Jianjun Yuan

Subject: Engineering, Electrical And Electronic Engineering Keywords: high-voltage cables; online diagnosis; impedance spectroscopy; condition monitoring

Online: 22 July 2024 (18:52:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1641.v1

Unshoring Process of a Temporary Column, in a Seventeen Storey Building in Sant Adrià Del Besós

Ignacio Costales Calvo, Jaume Font i Basté, Xavier Gimferrer, Miquel Llorens Solivera

Subject: Engineering, Architecture, Building And Construction Keywords: unshoring; high-rise building; hydraulic pistons; temporary prop; monitoring

Online: 22 July 2024 (08:38:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1112.v1

Optimizing Tempering Parameters to Enhance Precipitation Behavior and Impact Toughness in High-Nickel Steel

Guojin Sun, Qi Wang

Subject: Engineering, Mechanical Engineering Keywords: Tempering process; Precipitation; High-nickel steel; Impact toughness; EBSD

Online: 16 July 2024 (04:58:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0951.v1

Effect of High Glucose on Embryological Development of Zebrafish, Brachyodanio rerio through Wnt Pathway

Ebony Thompson, Justin Hensley, Renfang Song Taylor

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: high glucose; Embryological Development; Zebrafish; RNA-seq; Metabolic Pathway

Online: 11 July 2024 (11:33:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1447.v1

Genotypic Selection Using QTL for Better Productivity under High Temperature Stress in Tomato (Solanum lycopersicum L.)

Elsayed Elazazi, Laura Ziems, Tariq Mahmood, Naeema Eltanger, Maryam Al-Qahtani, Nafeesath Shahsil, Aisha Al-Kuwari, Mohammed M. Metwally, Richard Trethowan, Chongmei Dong

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: high temperature stress; QTL; SNP marker; genotypic selection; tomato

Online: 21 June 2024 (05:27:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1104.v1

MR protocol optimization for Hepatobiliary Phase Imaging with Gadoxetic Acid for 1.5T: Comparison Between Breath-Hold T1-weighted and High Resolution Navigated 3D T1-weighted sequences

Eliseo Picchi, Valentina Ferrazzoli, Valeria Liberto, Luca Toti, Raffaella Giocondo, Valerio Da Ros, Noemi Pucci, Silvia Minosse, Francesco Garaci, Francesca Di Giuliano

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Magnetic Resonance; Gadoxetic Acid; High Resolution Navigated 3D; Hepatocarcinoma

Online: 17 June 2024 (08:06:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0705.v1

Rapid Growth of Population, GDP, and Built-up Land Exposed to High Seismic Hazard in Large Cities, China

Huiduo Wang, Qiang Dong, Weijiang Li, Jiahong Wen, Qing Wu, Yanming Chen, Jianli Liu, Li Li

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Earthquake; Exposure; High Seismically Hazardous Zone; Large City; China

Online: 11 June 2024 (15:40:05 CEST)

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In the context of rapid urbanization, the spatiotemporal patterns of socio-economic exposed to high seismic hazard in large cities lacks quantitative assessment, thus, it is difficult to understand the evolution of earthquake catastrophe risk there. In this paper, exposure change rate, and absolute and relatively exposure indices were proposed to quantitatively study the changes of spatiotemporal exposure to high seismic hazard in urban areas of large cities (i.e., permanent residents in urban areas more than 1 million) in Chinese mainland, using a set of multi-temporal population, GDP, and built-up datasets and a seismic hazard zoning map. The results show that, 64 out of 78 large cities are entirely or partially located in high seismically hazardous zones. Although the urban areas of large cities in high seismically hazardous zones (HSHUAs) cover only 1.73% (167177 km²) of mainland China, their share of population, GDP, and built-up land amounted to 18.14%, 30.24% and 24.55%, respectively, in 2015. Unprecedented urbanization has led to a dramatic exposure growth in HSHUAs between 1990 and 2015. The population, GDP, and built-up land in HSHUAs increased by 110 million people (with an average annual growth rate of 2.37%), 273.71 trillion USD(average annual growth rate of 11.15%), and 10593 km2 (average annual growth rate of 2.02%), respectively. HSHUAs experienced much faster population and GDP growth than the whole country, while relatively slower growth in built-up land. Exposure growth in HSHUAs also was varied for different types of large cities. Megacities had a higher proportion of increased GDP and population in HSHUAs, induced by industry and population agglomeration. Whereas, Type II large cities had a higher proportion of increased built-up land in HSHUAs, driven mainly by urban sprawl. Our analysis indicates that, for large cities under rapid urbanization, it is an urgent need to strengthen resilient urban planning, renewal and construction.

Preprint ARTICLE | doi:10.20944/preprints202406.0237.v1

High Strain Rate Deformation Behavior of Gradient Rolling AZ31 Alloy

YingJie Li, Hui Yu, Chao Liu, Yu Liu, Wei Yu, Yuling Xu, Binan Jiang, KwangSeon Shin, Fuxing Yin

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: AZ31; high strain rate; gradient rolling; microstructure; mechanical property

Online: 7 June 2024 (11:17:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0439.v1

Reproductive Outcomes in High-Yielding Holstein Cows Following Administration of GnRH on Day 5 After Artificial Insemination

Silviu-Ionuț Borș

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: high yielding cows; gonadorelin; accessory corpus luteum; reproductive parameters

Online: 7 June 2024 (11:02:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0063.v1

Nitric Oxide as a Novel Biomarker for Monitoring Heat Exposure Responses in High Glucose- maintained Keratinocytes

Syeda Tayyiba Rahat, Ilkka Miinalainen, Anni Nieminen, Seppo Vainio, Nsrein Ali

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Keratinocytes; high glucose; heatwaves; NO; HSP-70; metabolites; diabetes

Online: 3 June 2024 (12:09:49 CEST)

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Global warming and the associated increasing frequency of heatwaves are on the rise leading to numerous health complications. Diabetic patients are more vulnerable to heat exposure than healthy individuals, owing to their impaired sweating ability, however, little is known about how heat exposure may impact the function of skin cells, commonly keratinocytes. Our recent report provided the first proof-of-concept revealing that the metabolic composition of sweat EVs is associated with metabolic changes in healthy individuals and type 2 diabetes patients. Given this and the shared cellular proprieties of eccrine sweat glands with keratinocytes, we questioned whether the metabolic changes in sweat EVs may mirror the responses of keratinocytes upon heat exposure. To this, we exposed HaCat, which were maintained in low (mimicking healthy condition) and high glucose (mimicking diabetes condition) to acute (90 min), chronic (48 h), and repetitive heat exposure at 40 ⁰C. Through conducting a set of experiments including a targeted metabolomics approach, Greiss assay, western blotting analysis, and electron microscopy studies. The data demonstrate that heat exposure results in substantial changes of metabolite levels belonging to amino acids, pyrimidine metabolism, and glycolysis pathways in high glucose maintained HaCat cells when compared to those noted in low glucose condition. Exploring the molecular mechanisms through which heat exposure may impact the metabolic composition in keratinocytes, our discoveries highlight nitric oxide (NO) as a novel biomarker that the level is correlated with heat duration and frequency. Furthermore, data reveal that the HSP-70 protein levels and mitochondrial morphology are consequently altered. This study provides evidence of shared metabolic alterations in keratinocytes and sweat EVs collected from clinical study and proposes, for the first time, NO as a novel biomarker for monitoring changes in health and diabetes upon heat exposure.

Preprint ARTICLE | doi:10.20944/preprints202405.2087.v1

Cardiovascular Alterations in Workers Performing at High Altitude on the Etna Volcano

Ermanno Vitale, Giulia Laterra, Veronica Filetti, Serena Matera, Ginevra Malta, Nektaria Zagorianakou, Marco Barbanti, George Dounias, Venerando Rapisarda, Andrea Marconi

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: High altitude workplace; occupational medicine; cardiovascular alterations; CVDs; Etna

Online: 31 May 2024 (08:10:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.2059.v1

Global-Local Deep Fusion: Semantic Integration with Enhanced Transformer in Dual-Branch Networks for Ultra-High Resolution Image Segmentation

Chenjing Liang, Kai Huang, Jian Mao

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: ultra-high resolution image segmentation; enhanced transformer; feature fusion

Online: 31 May 2024 (02:37:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1550.v1

Highly Accuracy and Lightweight Detection of Apple Leaf Diseases Based on YOLO

Zhaokai Sun, Zemin Feng, Ziming Chen

Subject: Computer Science And Mathematics, Robotics Keywords: leaf disease detection; YOLO; high-accuracy detection; lightweight detection

Online: 23 May 2024 (12:43:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0899.v1

Identification and Expression Analysis of Long Noncoding RNAs in Response to Infection with VHSV in Rainbow Trout

Mahmoud Tavakoli alamouti, Ghodrat Rahimi Mianji, Ardeshir Nejati Javaremi, Ayoub Farhadi, Elham Younesi

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: lncRNAs; Oncorhynchus mykiss; VHSV; differential expression; high-throughput sequencing

Online: 14 May 2024 (11:37:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0854.v1

Nano Electrocatalysts Engineering for Hydrogen Evolution Reaction by Water Splitting at High Current Density

Longlu Wang

Subject: Physical Sciences, Chemical Physics Keywords: high current density; hydrogen evolution reaction; electrocatalyst; water splitting

Online: 13 May 2024 (12:30:45 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202301.0155.v4

Benveniste’s Experiments and the So-Called “Water Memory” Phenomenon: an Example of Serendipity? Investigation and Experiments

Francis BEAUVAIS

Subject: Medicine And Pharmacology, Other Keywords: Water memory; High dilutions; Scientific controversy; Serendipity; Experimenter effect

Online: 10 May 2024 (03:14:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1429.v1

Narrative Review on Multiple Gestation: A Clinician’s Pocket Guide to Navigate Management of Multiple Gestation with an Evidence-Based Perspective

Jeffrey Morgan Denney, Sophia Nicole Brancazio, Lexi Rose Frankel, Kristen Helane Quinn

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: high risk pregnancy; twin pregnancy; triplet pregnancy; multiple gestation

Online: 23 April 2024 (11:46:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0085.v1

Effect of High Sucrose Diet on the Occurrence and Progression of Diabetic Retinopathy and Dietary Modification Strategies

Chen Yang, Yifei Yu, Jianhong An

Subject: Medicine And Pharmacology, Ophthalmology Keywords: high-sucrose diet; diabetic retinopathy; hyperglycaemia; dietary modification strategies

Online: 1 April 2024 (14:41:38 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202403.1754.v1

Promising Algorithm Addressing the Mechanism and Charac-teristic Curves of Insulated Gated Bipolar Transistor (IGBT)

Hsin-Chia Yang, Sung-Ching Chi, Pei-Jun Yang, Bo-Hao Huang

Subject: Physical Sciences, Applied Physics Keywords: IGBT; BCD; Breakdown Voltage; High Current Gain; Kink effects

Online: 28 March 2024 (13:35:51 CET)

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