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Preprint ARTICLE | doi:10.20944/preprints202112.0415.v1

Multicenter Retro-Prospective Observational Study on Chronic Hypoparathyroidism and rhPTH (1-84) Treatment

Gemma Marcucci, Guglielmo Beccuti, Giulia Carosi, Filomena Cetani, Luisella Cianferotti, Anna Maria Colao, Carolina Di Somma, Mirko Duradoni, Antonia Elefante, Lucia Ghizzoni, Massimo Giusti, Andrea Gerardo Lania, Elisabetta Lavezzi, Bruno Madeo, Giovanna Mantovani, Claudio Marcocci, Laura Masi, Simone Parri, Francesca Pigliaru, Assunta Santonati, Antonio Spada, Lara Vera, Maria Luisa Brandi

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Chronic Hypoparathyroidism; rhPTH (1-84); Natpar®; Treatment

Online: 24 December 2021 (23:55:38 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1436.v1

Cognitive Impairment and Brain Atrophy in Patients with Non-Dialysis and Dialysis Dependent Chronic Kidney Disease

Kazuhiko Tsuruya, Hisako Yoshida

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: brain atrophy; cognitive impairment; chronic kidney disease; dialysis; exercise

Online: 18 January 2024 (15:58:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.1884.v1

Relationship between Modern ART Regimens and Immunosenescence Markers in Patients with Chronic HIV Infection

Rusina Stanislavova Grozdeva, Nina Stoyanova Yancheva-Petrova

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: ageing; HIV-1; combined antiretroviral therapy; chronic inflamation

Online: 27 June 2024 (05:47:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0346.v1

A Highly Transparent and Explainable Artificial Intelligence Tool for Chronic Wound Classification: XAI-CWC

Salih Sarp, Murat Kuzlu, Emmanuel Wilson, Umit Cali, Ozgur Guler

Subject: Engineering, Control And Systems Engineering Keywords: Chronic wound classification; transfer learning; explainable artificial intelligence.

Online: 18 January 2021 (14:28:04 CET)

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Preprint REVIEW | doi:10.20944/preprints201810.0033.v1

Viral Persistence and Chronicity in Hepatitis C Virus Infection: Role of T-Cell Apoptosis, Senescence and Exhaustion

Muttiah Barathan, Rosmawati Mohamed, Yean K. Yong, Meganathan Kannan, Jamuna Vadivelu, Alireza Saeidi, Marie Larsson, Esaki Muthu Shankar

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: apoptosis; viral persistence, hepatitis C virus; immunity; chronic infection

Online: 2 October 2018 (16:34:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1753.v1

A Systematic Review and Bayesian Meta-Analysis of Medical Devices Used in Chronic Pain Management

Ashish Shetty, Gayathri Delanerolle, Chunli Deng, Heitor Cavalini, Xiaojie Yang, Anish Thillainathan, Yassine Bouchareb, Amy Boyd, Peter Phiri, Jian Shi

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Chronic pain; Medical Devices; Neuromodulation; Clinical trials; Bayesian

Online: 25 May 2023 (07:27:31 CEST)

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Chronic non-cancer pain is a highly debilitating condition affecting approximately 20% of the global population. Chronic pain may lead to significant physical disability, emotional distress, social isolation and financial burden. Whilst^.pharmacological therapies remain the cornerstone of pain management in non-cancerous chronic pain, factors including the current opioid epidemic have led to non-pharmacological techniques becoming a more attractive proposition. We explored the prevalence of medical device use and their treatment efficacy in non-cancer pain management. A systematic methodology was developed, peer reviewed and published in PROSPERO (CRD42021235384). Key words of medical device, pain management devices, chronic pain, lower back pain, back pain, leg pain and chronic pelvic pain using Science direct, PubMed, Web of Science, PROSPERO, MEDLINE, EMBASE, PorQuest and ClinicalTrials.gov. All clinical trials, epidemiology and mixed methods studies that reported the use of medical devices for non-cancer chronic pain management published between the 1^st of January 1990 and the 30^th of April 2022 were included. 13 studies were included in systematic review, of these 6 were used in the meta-analysis with 173 participants. Our meta-analysis for pain reduction in each study showed that transcutaneous electrical nerve stimulation combined with instrument-assisted soft tissue mobilization treatment and pulsed electromagnetic therapy produced significant treatment on chronic lower back pain patients. Pooled evidence revealed the use of medical device related interventions resulted in 0.7 degree of pain reduction under a 0-10 scale. Significant improvement in disability scores, with a 7.44 degree reduction in disability level compared to a placebo using a 50 score range was also seen. The application of medical devices in patients with chronic pain has gained popularity due to increasingly cost effective techniques, minimally invasiveness and greater awareness of risks associated with pharmacological management. Our analysis has shown that the optimal use of medical devices in a sustainable manner requires further extensive research, needing larger cohort studies with greater gender parity, in a more diverse range of geographical locations.

Preprint ARTICLE | doi:10.20944/preprints202212.0224.v1

Autoantibody Correlation Signatures in Fibromyalgia and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Association with Symptom Severity

Varvara A Ryabkova, Natalia Y Gavrilova, Alina A Poletaeva, Aleksandr I Pukhalenko, Irina A Koshkina, Leonid P Churilov, Yehuda Shoenfeld

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: fibromyalgia; myalgic encephalomyelitis/chronic fatigue syndrome; autoantibodies; autoimmunity

Online: 13 December 2022 (02:47:48 CET)

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(1) Background: Recent studies provide some evidence for the contribution of antibody-mediated autoimmune mechanisms to the nature of fibromyalgia (FM) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Much attention was paid to the autoantibodies (AAb) targeting G protein-coupled receptors as natural components of the immune system. However, natural AAb network is much more extensive, and has not been previously investigated in these disorders; (2) Methods: The enzyme immunoassays ELI-Viscero-Test and ELI-Neuro-Test were used to determine changes in serum content of a 33 natural AAb to neural, organ-specific and non-tissue-specific autoantigens a) in 11 FM patients with comorbid ME/CFS; b) in 11 ME/CFS patients without FM; c) in 11 healthy controls. Individual autoantibody profiles and their correlation with some clinical symptoms were analyzed. (3) Results: both patients with ME/CFS and ME/CFS+FM were characterized by more frequent and pronounced deviations in the immunoreactivity to GABA-receptors than healthy controls. Although the level of other natural AAb did not differ between study groups, AAb correlation signatures were changing in patients compared to healthy controls. Both in patients and healthy controls the level of natural AAb to various neural and tissue-specific antigens correlated with the severity of fatigue, bodily pain, depression, anxiety, physical and mental-health related quality of life. Notably, that widely different correlation patterns were observed between study groups. (4) Conclusions: Findings from this pilot study provide some evidence that the homeostasis of autoimmune relationships, which are possibly a physiological part of our immune system, may break down in FM and ME/CFS. The correlation of disease-induced perturbations in individual AAb profiles with some clinical symptoms may arise from the immune system's ability to reflect qualitative and quantitative changes in antigenic composition of the body.

Preprint ARTICLE | doi:10.20944/preprints202106.0493.v1

Long-term recovery of the fecal microbiome and metabolome of dogs with steroid-responsive enteropathy

Rachel Pilla, Blake Guard, Amanda B Blake, Mark Ackermann, Craig Webb, Steve Hill, Jonathan A Lidbury, Joerg M Steiner, Albert Jergens, Jan Suchodolski

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: Chronic diarrhea, idiopathic inflammatory bowel disease, microbiota, dysbiosis

Online: 21 June 2021 (08:56:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.2096.v1

The Late Asymptomatic and Terminal Immunodeficiency Phases in Experimentally FIV-Infected Cats- a Long-Term Study

Brian G Murphy, Diego Castillo, Sarah Elisabeth Cook, Chrissy Eckstrand, Samantha Evans, Ellen Sparger, Chris Grant

Subject: Biology And Life Sciences, Virology Keywords: Cat; FIV; lentivirus; FAIDS; lymphoma; chronic renal failure

Online: 31 July 2023 (10:29:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0848.v1

Clinical and Diagnostic Features of Post-Acute COVID-19 Vaccination Syndrome (PACVS)

Anna Katharina Mundorf, Amelie Semmler, Harald Heidecke, Matthias Schott, Falk Steffen, Stefan Bittner, Karl J. Lackner, Karin Schulze-Bosse, Marc Pawlitzki, Sven Guenther Meuth, Frank Klawonn, Jana Ruhrländer, Fritz Boege

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: post-acute COVID-19 vaccination syndrome; PACVS; interleukin-6; interleukin-8; malaise/ chronic fatigue; cognitive impairment; peripheral nerve dysfunction

Online: 12 June 2024 (14:36:05 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202305.0453.v1

Development of a Modified Global Physical Activity Questionnaire and its Construct Validity among Adults in Kerala, India

Thirunavukkarasu Sathish, Elezebeth Mathews

Subject: Public Health And Healthcare, Other Keywords: physical activity; GPAQ; validity; self-reports; chronic diseases

Online: 8 May 2023 (05:20:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0171.v1

The Antineoplastic Role of STAT5 Inhibition in BCRABL1-Positive Cells Exposed to Pimozide Alone and in Combination with Dasatinib and Ponatinib

Marco Santoro, Salvatrice Mancuso, Manlio Tolomeo, Rosaria Maria Pipitone, Stefania Grimaudo, Sergio Siragusa

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: chronic myeloid leukemia; dasatinib; ponatinib; pimozide; STAT inhibitors; K562

Online: 11 October 2021 (16:17:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0432.v1

Chronic Fatigue Syndrome and Fibromyalgia-Like Symptoms Are an Integral Component of the Phenome of Schizophrenia: Neuro-Immune and Opioid System Correlates

Rana Fadhil Mousa, Hussein Kadhem Al-Hakeim, Amir Alhaidari, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: chronic fatigue syndrome; myalgic encephalomyelitis; schizophrenia; neuroimmunomodulation; inflammation; biomarkers

Online: 29 March 2020 (10:52:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1055.v1

Relationship of Serum Zonulin Level with Renal Functions, Systemic Inflammation and Endothelial Dysfunction in Patients with Chronic Kidney Disease

Ali Kirik, Omer Toprak, Hacer Sen, Saliha Uysal, Suleyman Emre Kocyigit, İldeniz Bilgicler, Elif Parlak, Tugcin Mutlu, Ozge Kama Bascı

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Zonulin; chronic kidney disease; systemic inflammation; endothelial dysfunction

Online: 14 August 2024 (11:54:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0145.v1

Associations between Physical Disability and Chronic Diseases with Depressive Symptoms in Vietnamese-Origin Older Adults in the United States

Christina E Miyawaki, Joshua M Garcia, Luis D Medina, Kim N Nguyen, Oanh L Meyer, Kyriakos S Markides

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: chronic diseases; depressive symptoms; disability; older adults; Vietnamese

Online: 3 January 2024 (08:39:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.1478.v1

Contribution of echocardiography and 2D strain in the detection of subtle myocardial involvement in group A and B patients with chronic obstructive pulmonary disease

Rania Kaddoussi, Ikram Chamtouri, Wafa Dhouib, Elassoufi Fatima ezzahra, Monia Daami, Walid Jomaa, Wissal Rouetbi, Khaldoun Ben Hamda

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: chronic obstructive pulmonary disease; subtle myocardial involvement; echocardiography; strain

Online: 18 July 2024 (09:35:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0152.v1

Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Massimo Sangiorgi, Mariangela Valentina Puci, Allegra Rosa Martelli, Teresa Messina, Paolo Frigatti, Maria Pia Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco Michelino Fiore, Armado Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, Diego Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Pietro Modugno, Maurizio Maiorano, Umberto Marcello Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, Giovanni Maria Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munaó, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio Stefano Tolva, Ilenia D'Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D'Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio Massimo Oddi, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: chronic limb-threatening ischemia; outcome; sex; age; limb salvage

Online: 8 December 2022 (09:39:30 CET)

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Preprint REVIEW | doi:10.20944/preprints202409.0272.v1

Relationship between Sleep Disturbances and Chronic Pain: A Narrative Review

Sejal V Jain, Geoffrey D Panjeton, Yuri Chaves Martins

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: bidirectional relationship; chronic pain; polysomnography; sleep disorders; sleep disturbances

Online: 5 September 2024 (06:05:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1522.v1

A Review and Meta-Analysis of the Effect of Atenolol on All-Cause Mortality Risk among Asians With Chronic Progressive Diseases

Abdullah Alkattan, Eman Alsalameen, Alaa Harmoush, Mhd Nour Farawati, Hind Alsharif, Nagla Mahmoud, Mhd Ali Farawati, Amjad Alfaleh, Mahmoud Kandeel, Nashwa Radwan

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Atenolol; mortality; Asians; chronic progressive disease; cardiovascular disease

Online: 22 September 2023 (04:36:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0567.v1

Stable Coronary Artery Disease: Who Finally Benefits from Coronary Revascularization in the Modern Era? The ISCHEMIA and Interim ISCHEMIA-EXTEND Analysis

Leonid L Bershtein, Alexey Sumin, Elizaveta Zbyshevskaya, Victoria Gumerova, Darejan Tsurtsumia, Igor Kochanov, Alina Andreeva, Vartan Piltakian, Sergey Sayganov

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: chronic coronary syndromes; revascularization; prognosis; ISCHEMIA; ISCHEMIA-EXTEND

Online: 8 June 2023 (02:13:16 CEST)

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Working Paper ARTICLE

Effects of Chronic Lithium Treatment on Anxious Behaviors and Serotonergic Genes Expression in the Midbrain Raphe Nuclei of Defeated Male Mice

Dmitriy A. Smagin, Irina L Kovalenko, Anna G. Galyamina, Irina V Belozertseva, Nikolay V Tamkovich, Konstantin O Baranov, Natalia N. Kudryavtseva

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: chronic social defeat stress; anxiety; lithium chloride; mice

Online: 3 June 2021 (11:41:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0782.v1

Appropriateness of Ketoanalogues of Aminoacids, Calcium Citrate, and Inulin Supplementation for CKD Management: A RAND/UCLA Consensus

Nadia Saavedra-Fuentes, Enrique Carmona-Montesinos, Gilberto Castañeda-Hernández, Israel Campos, Juan Carlos Castillo-Salinas, Javier Alberto Castillo-Tapia, Karla Guadalupe Del Castillo-Loreto, Juan Carlos Falcón-Martínez, Raquel Fuentes-García, Miguel Ángel García de León Guerrero, Victor García-García, Erika F. Gómez-García, Rafael González-Toledo, Angélica Jaime, Kely Rely, Claudia Lerma, Luis E. Morales-Buenrostro, Mateo Quilantan-Rodriguez, Adrián Rodriguez-Matías, F. Octavio Rojas-Rodriguez, Rafael Valdez-Ortiz, Michael Wasung, Berenice Ceron-Trujullo, Edgar Ramirez-Ramirez

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: ketoanalogues of amino acids; inulin; calcium citrate; consensus; chronic kidney disease; supplementation

Online: 12 August 2024 (10:26:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202301.0447.v1

Still Finding Ways to Augment the Existing Management of Acute and Chronic Kidney Diseases with Targeted Gene and Cell Therapies: Opportunities and Hurdles

Peter Corridon

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: acute kidney disease; chronic kidney disease; gene therapy; cell therapy

Online: 25 January 2023 (04:29:25 CET)

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Preprint REVIEW | doi:10.20944/preprints201807.0320.v1

Vitamin D Deficiency in Chronic Kidney Disease: Recent Evidence and Controversies

Pedro Henrique Franca Gois, Martin Wolley, Dwarakanathan Ranganathan, Antonio Carlos Seguro

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: vitamin D; vitamin D deficiency; chronic kidney disease; proteinuria

Online: 18 July 2018 (08:39:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1738.v1

Novel Insight into the Effect of Balneotherapy on Changes in the Functional State in Patients with Chronic Low Back Pain: Integration of Physical and Mental Healthcare Indicators and Patients’ Health Perception

Dragana Terzic Markovic, Sanja Kocic, Jovana Bradic, Aleksandra Jurisic Skevin, Biljana Jakovljevic, Biljana Majstorovic, Zvonko Dimoski, Goran Stojanovic, Vesna Maksimovic, Katarina Pavlovic Jugovic, Marijana Dabic, Danijela Jezdimirovic, Sandra Zivanovic

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: chronic low back pain; balneotherapy; functionality; life quality; pain

Online: 23 July 2024 (07:40:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1270.v1

Estimation of the Cadmium Nephrotoxicity Threshold from Loss of GFR and Albuminuria

Soisungwan Satarug, David A. Vesey, Tanaporn Khamphaya, Phisit Pouyfung, Glenda C. Gobe, Supabhorn Yimthiang

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: albuminuria; blood pressure; cadmium; chronic kidney disease; estimated GFR

Online: 17 August 2023 (08:07:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints201802.0104.v1

Myeloperoxidase as an Active Disease Biomarker: Its Recent Biochemical and Pathological Perspectives

Amjad A. Khan, Mohammad A. Alsahli, Arshad H. Rahmani

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: myeloperoxidase, leukocytes, inflammation, oxidative stress, chronic diseases, disease biomarker

Online: 15 February 2018 (16:54:25 CET)

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Preprint REVIEW | doi:10.20944/preprints202405.1346.v1

Perioperative Buprenorphine Management and Post-Operative Pain Outcomes: A Retrospective Study with Literature Review and Recommendations

Amruta Desai, Shruti Parikh, Sergio Bergese

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: ; buprenorphine; perioperative medicine; chronic pain; opioid use disorder ;

Online: 21 May 2024 (05:33:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0376.v1

Association of Migraine and Irritable Bowel Syndrome in Saudi Arabia: A Nationwide Survey.

Khalid A. Bin Abdulrahman, Nawaf S. Alenazi, Saad B. Albishri, Faisal F. Alshehri

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Migraine; Headache; Irritable Bowel Syndrome; Chronic Pain; Saudi Arabia

Online: 18 August 2021 (11:21:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1869.v1

The Roles of MicroRNAs in Obesity: Emphasizing Links with Chronic Kidney Disease and Cardiovascular Disorders

Valérie Metzinger-Le Meuth, Laurent Metzinger

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: RNA; obesity; chronic kidney disease; cardiovascular disorder; gene regulation

Online: 27 June 2023 (10:45:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.1270.v1

Role of EUS in Early Chronic Pancreatitis

Jimil Shah, Abhirup Chatterjee, Truptesh H Kothari

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: chronic pancreatitis; alcohol; SPINK1; Abdominal pain

Online: 17 January 2024 (05:55:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0210.v1

Improving the Cognitive Impact of Migraine: A Real-World Study on the Ability to Concentrate

Isabel Pavão Martins, Beatriz Nunes Vicente, João Bajouco Nobre, Mariana Dias da Costa, Filipa Dourado Sotero

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: cognitive impact; chronic migraine; migraine burden

Online: 3 January 2024 (09:43:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints201901.0220.v1

Renoprotective Effect of Laminaria japonica Polysaccharide in Adenine-Induced Chronic Renal Failure

Miao Long, Qiang-Ming Li, Qing Fang, Li-Hua Pan, Xue-Qiang Zha, Jian-Ping Luo

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Laminaria japonica; polysaccharide; chronic renal failure

Online: 22 January 2019 (11:50:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints201902.0029.v1

Shared Microglial Mechanisms Underpinning Depression and Fatigue and Their Comorbidities

Adriano José Maia Chaves Filho, Danielle S. Macedo, David Freitas de Lucena, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: major depressive disorder, microglia, cytokines, neuro-immune, chronic fatigue, oxidative stress

Online: 4 February 2019 (11:41:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints201907.0262.v1

Chronic Fatigue and Fibromyalgia Symptoms are Key Components of Deficit Schizophrenia and are Strongly Associated with Activated Immune-Inflammatory Pathways

Abbas Almulla, Hussein Al-Hakeim, Mokhlad Abed, André Carvalho, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Chronic fatigue syndrome, inflammation, neuro-immune, physio-somatic, schizophrenia, cytokines

Online: 23 July 2019 (11:49:41 CEST)

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Working Paper COMMUNICATION

Dietary Fiber and Gut Microbiota in Renal Diets

carla Camerotto, Adamasco Cupisti, Claudia D'Alessandro, Fulvio Muzio, Maurizio Gallieni

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: renal diets; fiber; renal nutrition; chronic kidney disease; gut microbiota

Online: 26 August 2019 (12:23:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0191.v1

General Anesthetic Agents and Renal Function after Nephrectomy

Ho-Jin Lee, Jinyoung Bae, Yongsuk Kwon, Hwan Suk Jang, Seokha Yoo, Chang Wook Jeong, Jin-Tae Kim, Won Ho Kim

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: nephrectomy; acute kidney injury; chronic kidney disease; sevoflurane; desflurane; propofol

Online: 19 August 2019 (03:47:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0609.v1

Treatment-Free Remission in Chronic Myeloid Leukaemia: Can We Identify Prognostic Factors?

Hilbeen Hisham Saifullah, Claire Marie Lucas

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Chronic myeloid leukaemia; chronic phase; Tyrosine kinase inhibitor; Treatment free remission; deep molecular response; BCR-ABL.

Online: 25 June 2021 (08:13:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0301.v2

Therapeutic Effects of Traditional Chinese Medicine Formula Qianlie Tongli Decoction on Chronic Prostatitis/Chronic Pelvic Pain Syndrome Induced by Peptide T2 in Mice

Xingxing Cui, Muhammad Naveed, Mirza Muhammad Faran Ashraf Baig, Wenlu Wang, Reyaj Mikrani, Ziwei Liu, Bilal Ahmed, Meng Tang, Junaid Wazir, Xiaohui Zhou

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Qianlie Tongli decoction; chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS); anti-inflammation; therapeutic effects; immunization

Online: 24 April 2020 (04:30:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0113.v1

Neurosecretory Protein GM-Expressing Neurons Participate in Lipid Storage and Inflammation in Newly Developed Cre Driver Mice

Yuki Narimatsu, Masaki Kato, Eiko Iwakoshi-Ukena, Shogo Moriwaki, Ayano Ogasawara, Megumi Furumitsu, Kazuyoshi Ukena

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: neurosecretory protein GM; hypothalamus; neuropeptide; obesity; chronic inflammation; chemogenetics

Online: 2 November 2023 (07:43:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0527.v1

Finite Mixture Models Based on Pain Intensity, Functional Disability and Psychological Distress Composite Assessment Allow to Identify Two Distinct Classes of Persistent Spinal Pain Syndrome after Surgery Patients Related to Their Quality of Life

Amine Ounajim, Maxime Billot, Pierre-Yves Louis, Yousri Slaoui, Denis Frasca, Lisa Goudman, Manuel Roulaud, Nicolas Naiditch, Bertille Lorgeoux, Sandrine Baron, Kevin Nivole, Mathilde Many, Nihel Adjali, Philippe Page, Bénédicte Bouche, Elodie Charrier, Laure Poupin, Delphine Rannou, Géraldine Brumauld de Montgazon, Brigitte Roy-Moreau, Chantal H. Wood, Raphael Rigoard, Romain David, Maarten Moens, Philippe Rigoard

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: PSPS; FBSS; chronic pain; health-related quality of life; mixture models analysis; personalized pain management; chronic pain after spinal surgery

Online: 27 August 2021 (15:23:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202001.0087.v1

DPP-4/GLP-1 Axis as a Potential Therapeutic Target in Chronic Stress-related Vascular Aging and Atherosclerosis

Ying Wan, Limei Piao, Yongshan Nan, Xian-Wu Cehng

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Chronic stress; Vascular senescence; inflamamtion; atherosclerosis; dipeptidyl peptidase-4

Online: 9 January 2020 (13:05:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0675.v1

Prevalence of Fetal Inflammatory Response Syndrome and Villitis of Unknown Etiology in the Placenta of Saudi Women and Their Association with Baby Gender

Waleed Mohammed Aldahmash, Khaldoon Aljerian, Saleh Hamed Alwasel

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Inflammatory Response Syndrome; VUE; chronic deciduitis; CD8; CD68; Placenta; gender

Online: 10 November 2023 (07:29:45 CET)

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Long-term health consequences are influenced by circumstances that occur during pregnancy. The confluence of the maternal and fetal circulations occurs at the placenta, which is the first or-gan to develop. Placental pathology can provide an accurate diagnosis of inflammation inside the amniotic sac. The pathological alterations of preterm placentas provide evidence for the causes of numerous perinatal pathologies, including spontaneous preterm births. This retrospec-tive study aimed to re-examine placentas regarded as normal by the Obstetrics and Gynecology Department in our institution so that grading and staging of any evident inflammatory response could be evaluated and associated with baby gender. Eighty-four full-term placentas were col-lected after delivery. Placentas that were considered normal and were not sent to the histo-pathology department were taken. Morphological examination of fresh placenta was conducted. Full thicknesses of placenta samples were taken from central and marginal regions of placental disc. Fetal and maternal inflammatory responses syndrome were assessed. Villitis of unknown etiology (VUE) and chronic deciduitis also were evaluated in the placenta. Immunohistochemis-try (IHC) was also performed to evaluate patterns of inflammation in the placenta using an-ti-CD8 and anti-CD68 antibodies. The correlation between the silent pathologies and clinical complications or involvement of developing fetal inflammatory response syndrome was meas-ured. In this study, seventeen (20%) maternal inflammatory samples and ten (12%) fetal inflam-matory samples showed inflammatory responses. The frequency of chronic deciduitis and villi-tis of unknown etiology was more remarkable among Saudi pregnant women than the previ-ously reported findings in the literature of placental pathology. The prevalence of fetal and ma-ternal inflammatory response was greater in the placentas of mothers of males than in placentas of female mothers. Grading placental inflammation usually predict the degree of maternal an-ti-fetal cellular rejection. Fetal inflammatory response syndrome usually goes unnoticed in Sau-di Arabia. There are differences in the inflammatory response in the placenta based on the sex of the newborn. Increasing the number of placental samples that must be sent for microscopic in-spection may be preferable due to their significance in identifying the causes of chronic disor-ders.

Preprint ARTICLE | doi:10.20944/preprints202307.1294.v1

The Mediating Effects of Social Networks and Wisdom on the Relationship between Lifestyle Habits and Healthy Aging in Older Adults with Chronic Diseases

Hee-Kyung Kim, Hye-Suk Oh, Cheol-Hee Park

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: elderly; healthy aging; lifestyle habits; social networks; wisdom; chronic disease

Online: 19 July 2023 (09:53:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0050.v1

Effects of Continuous Prenatal Low Dose Rate Irradiation on Neurobehavior, Hippocampal Cellularity, mRNA and miRNA Expression on B6C3F1 Mice

FengRu Tang, Ignacia Braga Tanaka, Hong Wang, Salihah Lau, Satoshi Tanaka, Amanda Tan, Daisaku Takai, Akiko Abe

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Prenatal; low dose rate; chronic radiation exposure; brain effect

Online: 1 August 2024 (15:28:15 CEST)

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Abstract: Epidemiological, experimental, and ecological data have indicated the controversial effect of in utero chronic low dose rate (100 mGy) dose radiation exposure. Our main goal of this study was to examine if different low dose rates of chronic pre- or/and post-natal radiation exposure with accumulative high doses could induce hippocampal cellular, mRNA, and miRNA changes leading to neuropsychiatric disorders. The comprehensive mouse phenotypic traits, organ weight pathological, blood mRNA and miRNA changes were also studied. Using different approaches including SmithKline, Harwell, Imperial College, Royal Hospital, Phenotype Assessment (SHIRPA), neurobehavioral tests, pathological examination, immunohistochemistry, mRNA and miRNA sequencing, and real-time quantitative polymerase chain reaction ( qRT-PCR) validation, we found that in prenatally irradiated (100 mGy/d for 18 days with an accumulative dose of 1.8 Gy) 1-year-old mice, no cellular changes including neurogenesis, mature neurons and glial cells in the hilus of the dentate gyrus and development of cognitive impairment, neuropsychiatric disorders occurred. However, a significant reduction in body weight and mass index (BMI) was indicated by the SHIRPA test. A reduced exploratory behavior was shown by an open field test. Organ weight measurement showed a significant reduction of the testes, kidneys, heart, liver, and epididymides although no abnormal changes from pathological examination. mRNA and miRNA sequencing and qRT-PCR validation revealed the upregulation of Rubcnl, Abhd14b and downregulation of Hspa1b, P4ha1, and Banp genes in both hippocampus and blood of mice prenatally irradiated with 100 mGy/d. Meanwhile, downregulation of miR-448-3p, miR1298-5p in the hippocampus, miR-320-3p, miR-423-5p, miR-486b-5p, miR-486b-3p, miR-423-3p, miR-652-3p, miR-324-3p, miR-181b-5p, miR-let-7b and miR-6904-5p in the blood was induced. The target scan revealed that Rubcnl is one of the miR-181b-5p targets in the blood. We, therefore, concluded that prenatal chronic irradiation with a low dose rate of 100 mGy/d and accumulative dose of 1.8Gy or below may not induce significant adverse health effects on the offspring. Further study of different low dose rate radiation exposure with accumulative high doses may provide threshold doses for authorities or regulators to set new radiation safety guidelines to replace those extrapolated from acute high dose/dose rate irradiation to reduce unnecessary emergency evacuation or expanding once a nuclear accident or leakage occurs.

Preprint REVIEW | doi:10.20944/preprints202312.1329.v1

A Review about Lateral Ankle Instability and Emerging Alternative Outcome Monitoring Tools in Patients Following Ankle Ligament Reconstruction Surgery

Ibrahim Saliba, Alexandre Hardy, Wenzheng Wang, Raphael Vialle, Sylvain Feruglio

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: ankle instability; chronic ankle instability; postoperative management; diagnostics; NIRS

Online: 18 December 2023 (12:45:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202303.0549.v1

Beraprost and Overall Survival in Cats With Chronic Kidney Disease

Hiroyuki Ito, Takumi Matsuura, Tadashi Sano

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: beraprost; feline; chronic kidney disease; progression-free survival; overall survival

Online: 31 March 2023 (11:17:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1769.v1

Investigating the Efficacy of Kidney-Protective Lactobacillus Mixture-Containing pet Treats in Feline Chronic Kidney Disease and Its Possible Mechanism

Ching-Wen Tsai, Hsiao-Wen Huang, Ya-Jane Lee, Tsu-Cheng Hsu, Ming-Ju Chen

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: chronic kidney disease; gut microbiota; Lm pet treats; feline

Online: 25 December 2023 (11:19:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202106.0362.v1

Intersections between Pneumonia, Lowered Oxygen Saturation Percentage and Immune Activation Mediate Depression, Anxiety and Chronic Fatigue Syndrome-like Symptoms due to COVID-19: A Nomothetic Network Approach

Hawraa Al-Jassas, Hussein Al-Hakeim, Michael Maes

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; depression; chronic fatigue syndrome; inflammation; neuro-immune; psychiatry

Online: 14 June 2021 (13:01:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0580.v1

Prevalence of Clinical Signs and Symptoms of Temporomandibular Joint Disorders Registered in the EUROTMJ Database: A Prospective Study in a Portuguese Center

David Faustino Ângelo, Beatriz Mota, Ricardo São João, David Sanz, Henrique José Cardoso

Subject: Medicine And Pharmacology, Surgery Keywords: Temporomandibular joint disorders; parafunctional habits; risk factors; chronic diseases

Online: 9 May 2023 (07:10:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.2048.v1

Importance of Topographical Recognition of Pulmonary Arteries in Diagnostics and Treatment of CTEPH, Based on Analysis of a Dissected Case Model – Pilot Study

Matiss Zicans, Dzintra Kazoka, Mara Pilmane, Andris Skride

Subject: Medicine And Pharmacology, Anatomy And Physiology Keywords: pulmonary arteries; anatomy; dissection; chronic thromboembolic pulmonary hypertension; angiogram

Online: 29 June 2024 (06:02:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0339.v1

Comparative Analysis of Vascular Calcification Risk Factors and Biomarkers in Pre-Hemodialysis and Prevalent Hemodialysis Patients

Marko Petrović, Voin Brković, Marko Baralić, Ivko Maric, Nenad Petković, Sanja Stankovic, Natasa Lalic, Dejana Stanisavljevic, Višnja Ležaić

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: chronic kidney disease patients 1; vascular calcifications 2; risk factors 3

Online: 7 November 2023 (02:49:35 CET)

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Preprint REVIEW | doi:10.20944/preprints202307.0891.v1

The Endometrial Microbiota: Challenges and Prospects

Pauline Kaluanga Bwanga, Pierre-Luc Tremblay-Lemoine, Marie Timmermans, Stephanie Ravet, Carine Munaut, Michelle Nisolle, Laurie Henry

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: endometrial microbiota; microbiome; fertility; chronic endometritis; uterus; reproductive outcomes; endometriosis, oncology

Online: 13 July 2023 (09:25:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0538.v1

Prognostic Significance of Amino Acid and Biogenic Amines Profiling in Chronic Kidney Disease

Guillermo Gervasini, Zoraida Verde, Luz María González, Celia Chicharro, Laura González-Rodríguez, Ana Fernández-Araque, Sonia Mota-Zamorano, Alberto Pérez-Hernández, Virginio García-López, Fernando Bandrés, Nicolás Roberto Robles

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Chronic kidney disease; End-stage kidney disease; amino acids; metabolites

Online: 7 September 2023 (11:24:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0253.v1

Chronic Unpredictable Environmental Stress Impair Biochemical and Physiological Homeostatsis: Role in Diabetes Mellitus

Alok Raghav, Jamal Ahmad, Imrana Naseem

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: diabetes mellitus; ROS; carbohydrate metabolism; antioxidants; chronic unpredictable environmental stress

Online: 14 September 2018 (05:20:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0175.v1

Lowered Serum Cesium Levels in Schizophrenia: Association with Immune-Inflammatory Biomarkers and Cognitive Impairments

Abbas F. Almulla, Shatha Rouf Moustafa, Arafat Hussein Al-Dujaili, Hussein Kadhem Al-Hakeim, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: inflammation; neuroimmunomodulation; major depression; chronic fatigue syndrome; myalgic encephalomyelitis; biomarkers

Online: 14 February 2020 (01:53:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints201806.0381.v1

CLINICAL PROFILE OF PATIENTS WITH CORONARY TORTUOSITY AND ITS RELATION WITH CORONARY ARTERY DISEASE

Ankush Gupta, Prashant Panda, YASH SHARMA, Ashwin Mahesh, Prafull Sharma, Nalin Kumar Mahesh

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: coronary tortuosity; myocardial ischemia; coronary artery disease; chronic stable angina.

Online: 25 June 2018 (11:02:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0749.v1

Unveiling the Landscape of COVID-19 Vaccination in Saudi Arabia: A Socio-Demographic, Clinical, and Vaccine Profile Analysis

Gehad Subaiea, Nawaf Alkhateeb, Faisal Sahman, Abdulrahman Alsudayri, Abdulkarim Mohammed Almudayni, Hamoud Alrashidi, Abdulrahman Majid Alshammari, Ahmed Alsolami, Abdulmalik M. Alqarni, Abdulwahab Alamri, Yasser Alhabeeb, Sirajudheen Anwar

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: COVID-19 vaccination; Saudi Arabia; Cross-sectional study; Socio-demographic characteristics; Chronic conditions; Vaccine administration; Infection rates

Online: 13 February 2024 (12:40:53 CET)

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The worldwide competition to vaccinate against COVID-19 has highlighted the importance of immunization measures in containing the virus. Saudi Arabia, like the rest of the globe, must assess socio-demographic subtleties, chronic illnesses, vaccination effects, and public health policy implications as it navigates this complicated environment. This cross-sectional study examined Saudi COVID-19 vaccine in many ways. It examined the socio-demographic makeup of vaccine recipients, the prevalence of chronic conditions in this population, vaccine administration patterns, post-vaccination side effects, and vaccine-infection rates. A questionnaire-based online survey of 401 participants ensured gender, nationality, age, weight, and educational diversity. We analyzed vaccine manufacturer choice for each dosage, side effects after the first and second doses, and chronic diseases in the sample. Pfizer/BioNTech vaccines are preferred for all three doses, reflecting worldwide vaccination acceptance patterns. Side effects were not significantly different between vaccination kinds. Interestingly, immunization reduced infection rates, demonstrating the efficacy of COVID-19 vaccines. The data fills important information gaps and illuminates Saudi COVID-19 vaccination kinetics. These data support the global preference for mRNA vaccines, demonstrating the faith in this breakthrough technology. They also sponsor COVID-19 vaccine safety and effectiveness studies. The dramatic drop in infection rates among vaccinated people shows how vaccinations suppress the pandemic. These findings inform Saudi Arabia's immunization efforts. As booster doses become more common, long-term vaccination research is crucial. Vaccine reluctance, especially in certain demographics, must be addressed. Due to vaccines' protective potential, equitable vaccine distribution and large immunization programs are essential for herd immunity and pandemic management. This thorough cross-sectional study helps policymakers and healthcare practitioners build successful and inclusive COVID-19 immunization regimens in Saudi Arabia.

Preprint REVIEW | doi:10.20944/preprints201911.0190.v1

Epigenetic Signalling and RNA Regulation in Cardiovascular Diseases

Alessia Mongelli, Sandra Atlante, Tiziana Bacchetti, Fabio Martelli, Antonella Farsetti, Carlo Gaetano

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: epigenetics; nucleic acids; RNA; DNA; cardiovascular disease; chronic disease; aging, metabolism

Online: 16 November 2019 (00:59:04 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202209.0035.v2

Application of Amniotic Membrane Allografts in Advanced Venous Leg Ulcer: A Case Study and Literature Review

Naomi Lambert, Eric Vinke, Tyler Barrett, Matthew Regulski

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Chronic Venous Insufficiency; Venous Leg Ulcer; Dehydrated Amniotic Membrane Allograft

Online: 5 September 2022 (10:57:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1680.v1

Pentraxin 3 in Kidney Disease and Renal Replacement Therapies

Vincenzo Losappio, Infante Barbara, Annamaria Maiorano, Serena Simiele, Sara Rosato, Silvia Mercuri, Dario Troise, Giovanni Stallone, Paola Pontrelli

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Chronic kidney disease; Pentraxin-3; Renal Replacement Therapies; Inflammaging.; innate immunity

Online: 24 May 2023 (03:59:18 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202011.0668.v1

Case Report - Unstable Angina, Coronary Artery Disease, and Cannabis

Brian Entler, Brian Shaffer, Garrison Davis, Marc Incitti, Brian Piper

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: marijuana; medicinal cannabis (MC); chronic pain (CP); cannabidiol (CBD); tetrahydrocannabinol (THC)

Online: 26 November 2020 (11:22:28 CET)

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Rationale:First discovered in 1990, the endocannabinoid system (ECS) was initially shown to have an intimate relationship with central areas of the nervous system associated with pain, reward, and motivation. Recently, however, the ECS has been extensively implicated in the cardiovascular system with contractility, heart rate, blood pressure, and vasodilation. Emerging data demonstrates modulation of the ECS plays an essential role in cardio metabolic risk, atherosclerosis, and can even limit damage to cardiomyocytes during ischemic events.Patient Concerns:This case describes a 63-year-old male who presented to a primary care physician for a medical cannabis (MC) consult due to unstable angina (UA) not relieved by morphine or cardiac medications; having failed all first- and second-line poly-pharmaceutical therapies. The patient reported frequent, unprovoked, angina and exertional dyspnea.Diagnosis:Having a complex cardiac history, the patient first presented 22 years ago after a suspected myocardial infarction (MI). He re-presented in 2010 and underwent stent placement at that time for inoperable triple-vessel coronary artery disease (CAD) which was identified via percutaneous transluminal coronary angioplasty. UA developed on follow up and, despite medical management over the past 6 years, his UA became progressively debilitating.Interventions and Outcomes:In conjunction with his standard cardiac care, patient had a gradual lessening of UA related pain, including frequency and character, after using an edible form of medical cannabis (MC) (1:1 CBD:THC). Following continued treatment, he ceased long term morphine treatment and describes the pain as no longer crippling. As demonstrated by his exercise tolerance tests, the patient experienced an improved functional capacity and reported an increase in his daily functioning, and overall activity.Lessons:This case uniquely highlights MC in possibly reducing the character, quality, and frequency of UA; while concordantly improving functional cardiac capacity in a patient with CAD. Additional case reports are necessary to verify this.

Preprint HYPOTHESIS | doi:10.20944/preprints202305.2264.v1

Chronic Fatigue Syndrome and Multiple Sclerosis have Reduced Craniospinal Compliance and Dilated Pressurized Bridging Cortical Veins: A Hypothesis Illustrated with Two Case Studies

Grant Bateman, Alexander Bateman

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Chronic fatigue syndrome; myalgic encephalomyelitis; multiple sclerosis; cortical vein; venous pressure

Online: 31 May 2023 (14:31:49 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202405.0204.v1

Endoscopic Picture in Chronic Rhinosinusitis Associated with Gerd

Kalamkas T. Sagandykova, Natalia M. Papulova, Talapbek M. Azhenov, Aliya Darbekova, Jerome R. Lechien

Subject: Medicine And Pharmacology, Otolaryngology Keywords: Chronic rhinosinusitis; Endoscopic picture; Gastroesophageal reflux disease; Laryngopharyngeal reflux; Rhinosinusitis; Nasopharyngeal reflux. The Reflux Symptom Index (RSI); The Reflux Symptom Score (RSS)

Online: 6 May 2024 (08:47:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0645.v1

Best Administration Schedule for Optimal Efficacy and Safety of Arsenic Trioxide Treatment in Chronic Graft versus Host Disease

Dominique Rongvaux-Gaïda, Lieven Huysse, François Rieger, Carole Nicco

Subject: Medicine And Pharmacology, Hematology Keywords: Arsenic trioxide; Chronic Graft-versus-Host Disease; cGvHD; Corticosteroid; autoimmunity

Online: 11 March 2024 (15:18:01 CET)

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Chronic graft-versus-host disease (cGvHD) occurs in 20-50% of recipients following allogeneic haematopoietic stem cell transplantation (allo-HSCT). Corticosteroids (CS) remain the first line treatment but have suboptimal efficacy and carry the risk of long-term side effects. New agents with a better safety profile and higher efficacy, ideally combining immunomodulatory and antifibrotic properties, are urgently needed. From 2016 to 2020, we conducted a phase 2 clinical trial with ATO in chronic GvHD (ClinicalTrials.gov ID NCT02966301 - GMED16-001). This study aimed to evaluate the efficacy and safety of a first-line combination of arsenic trioxide (ATO) and CS in adult patients with cGvHD who require systemic therapy after a first allo-HSCT for a haematological disease. In this prospective, national, multicenter, single-arm, open-label phase II study, conducted in 5 university hospital centers in France, ATO was initiated within 10 days of starting CS at 1 mg/kg/day. Patients received 11 infusions of ATO per 4-week cycle, at a dose of 0.15 mg/kg per infusion. Patients received 1 or 2 cycles of treatment depending on the clinical response and the assessment of the treating physician. The results were published in July 2022 in a paper entitled "High Response Rate and Corticosteroid Sparing with ATO-Based First-Line Therapy in Chronic Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation". The GMED16-001 study demonstrated convincing efficacy and safety characteristics of the intravenous drug (Trisenox^®/Arscimed^®): the first-line use of ATO in addition to corticosteroids was associated with a high clinical response rate and correlated with rapid corticosteroid (CS) sparing in moderate to severe cGvHD after allo-HSCT. We performed a post-hoc analysis of the data to determine the best schedule for treating cGvHD patients with ATO. Our post-hoc analysis leads us to the conclusion that two cycles of ATO, at 0.15 mg/kg/day, 5 days per week for 4 weeks each, separated by a 4-week therapy-free interval, appears to be the most promising treatment schedule.

Preprint CASE REPORT | doi:10.20944/preprints202305.0560.v1

Effects of Whole-Body Cryostimulation on pain management and disease activity in active Rheumatic Polymyalgia: a Case-Report

Federica Verme, Alessandra Scarpa, Giorgia Varallo, Paolo Piterà, Paolo Capodaglio, Jacopo Maria Fontana

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Polymyalgia Rheumatica; Whole-Body Cryostimulation; Chronic Pain; Disease Activity; Rehabilitation

Online: 9 May 2023 (04:17:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202402.1023.v1

The Potential Role of Stem Cells in Wound Healing: A Systematic Review

Banu Farabi, Katie Roster, Rahim Hirani, Katharine Tepper, Mehmet Fatih Atak, Bijan Safai

Subject: Medicine And Pharmacology, Dermatology Keywords: stem cells; chronic wound; wound healing; dermatology

Online: 19 February 2024 (08:19:53 CET)

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Introduction: Wound healing is a complex cascade involving the orchestration of inflammatory cells, skin fibroblasts, keratinocytes, and endothelial cells. These cells achieve tissue repair through an interchange of cytokines and growth factors through a controlled inflammation, angiogenesis, and remodeling process. Disruptions in the wound-healing process by comorbid conditions lead to significant morbidity and mortality. Stem cell therapy has emerged as a new strategy to facilitate the wound healing process. Stem cells harvested from different sources can be used for wound repair and regeneration (endothelial progenitor cells, bone marrow, adipose tissue, dermal and inducible pluripotent stem cells). We aimed to review clinical, translational, and primary literature on stem cell therapies in chronic wounds and summarize practical clinical applications to dermatological care. Materials and Methods: A comprehensive search of Pubmed, Embase, Web of Science, Google Scholar, and Cochrane Library was conducted for studies relating to stem cells and wound healing. Duplicate results were removed using Covidence. Titles and abstracts were screened by two independent researchers (BF and KR), with discrepancies resolved through discussion and mutual agreement. Articles were excluded if they were review-type or commentary-type articles. Results: A total of 22,454 articles were retrieved from the search. Deduplication removed 905, and automation removed an additional 18,363 articles. After an initial screening of titles and abstracts, 170 articles remained. Full-text screening resulted in an additional 126 articles being removed, leaving 44 included studies. Discussion: Stem cells used for wound repair and regeneration include endothelial progenitor stem cells and adult stem cells, in the forms of bone marrow-derived mesenchymal stem cells, adipose tissue stem cells, and inducible pluripotent stem cells. Among these sources, adipose tissue-derived mesenchymal stem cells (AD-MSCs) are ideally used due to the abundant supply of fat tissue, ease of isolation, extensive proliferative capacities ex vivo, and their ability to secrete pro-angiogenic factors. AD-MSCs have been used to enhance wound healing in peripheral arterial disease, diabetic wounds, hypertensive ulcers, bullous diabeticorum, venous ulcers, and postsurgical wounds after Mohs micrographic surgery. These cells have been delivered to the tissue topically, with scaffolds, combined with plasma-rich proteins, and through atelocollagen in various human studies. These approaches, when combined with local wound care practices, resulted in decreased pain, shorter wound healing times, and better cosmesis. Conclusions: Stem cell transplantation is a potential therapeutic approach in the wound healing process. Transplanted stem cells do not only differentiate into multiple skin cell types but also provide cytokine and growth factors required for wound healing resulting in increased angiogenesis. Thus, this approach may be regarded as an attractive option for intractable wounds that cause major clinical problems, especially chronic lower leg wounds. It can also be used after Mohs micrographic surgery for defects left to heal by secondary intention. Stem cell application may reduce the overall cost burden on the healthcare system and improve the quality of life for patients.

Preprint REVIEW | doi:10.20944/preprints202401.0959.v1

Unraveling the Complex Web of Fibromyalgia: A Narrative Review

Sarah Al Sharie, Scott J. Varga, Lou’i Al-Husinat, Piercarlo Sarzi-Puttini, Mohammad Araydah, Batool Riyad Bal’awi, Giustino Varrassi

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Fibromyalgia, Chronic pain, Diagnosis, Management, Emerging treatments.

Online: 12 January 2024 (10:01:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0048.v1

Sa-β-Gal in Kidney Tubules as a Predictor of Renal Outcome in Patients with Chronic Kidney Disease

Pasquale Esposito, Daniela Picciotto, Daniela Verzola, Giacomo Garibotto, Emanuele Luigi Parodi, Antonella Sofia, Francesca Costigliolo, Gabriele Gaggero, Valentina Zanetti, Michela Saio, Francesca Viazzi

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: senescence; cell; chronic kidney disease; kidney tubules

Online: 1 December 2023 (05:32:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0559.v1

Optimization of RT-QuIC Assay Duration for Screening Chronic Wasting Disease in White-Tailed Deer

Gokhan Yilmaz, Tamara Morrill, Cian Ward, Gordon Mitchell, Andrei Soutyrine, Hanhong Dan, Min Lin, Jiewen Guan

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: RT-QuIC; Chronic Wasting Disease; Diagnostics; Optimization

Online: 7 September 2023 (15:45:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.1105.v1

The Role of Chronic Fatigue in Patients with Crohn’s Disease

Marcin Włodarczyk, Adam Makaro, Mateusz Prusisz, Jakub Włodarczyk, Marta Nowocień, Kasper Maryńczak, Jakub Fichna, Łukasz Dziki

Subject: Biology And Life Sciences, Life Sciences Keywords: Crohn’s disease; fatigue; pathophysiology; chronic fatigue syndrome

Online: 17 July 2023 (10:47:41 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202305.1381.v1

Chronic Viral Hepatitis in Children: Socio-Economic Implications in Romania

Irina Dijmărescu, Alexandra Coroleuca, Adrian Dumitru Dijmarescu

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: chronic viral hepatitis; socio-economic status; children

Online: 19 May 2023 (05:07:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0441.v1

Role of the Nephrologist in Non-Kidney Solid Organ Transplant (NKSOT)

Iris Viejo-Boyano, Luis Carlos López-Romero, Luis D'Marco, Ana Checa-Ros, María Peris-Fernández, Enrique Garrigós-Almerich, María Carmen Ramos-Tomás, Ana Peris-Domingo, Julio Hernández-Jaras

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: chronic kidney disease; solid organ transplant; nephrology

Online: 27 February 2023 (04:45:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0168.v1

Microbiome Responses to Fecal Microbiota Transplantation in Cats with Chronic Digestive Issues

Connie Rojas, Zhandra Entrolezo, Jessica K. Jarett, Guillaume Jospin, Dawn Kingsbury, Alex Martin, Jonathan A. Eisen, Holly H Ganz

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: fecal microbiota transplant; domestic cat; chronic enteropathies

Online: 10 January 2023 (02:15:25 CET)

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There is growing interest in the application of fecal microbiota transplants (FMTs) in small animal medicine, but there are few published studies that have tested their effectiveness in the domestic cat (Felis catus). Here we use 16S rRNA gene sequencing to examine fecal microbiome changes in 68 domestic cats with chronic digestive issues that underwent FMT treatment using lyophilized stool that was delivered in oral capsules. Fecal samples were collected from FMT recipients before and two weeks after treatment, as well as from their stool donors, and healthy animals. We found that according to their owners, 77% of cats were reported to show improvement in their clinical signs (termed ‘Responders’), and 23% were reported to exhibit no change or a worsening of their clinical signs (termed ‘Non-Responders’). Variation in the fecal microbiomes of FMT recipients most strongly correlated with host clinical signs, diet, and IBD diagnosis. The relative abundances of Collinsella, Negativibacillus, Parabacteroides, and Peptoclostridium changed differentially in FMT recipients. Overall, on average 13% of the bacterial amplicon sequence variants (ASVs) were shared between stool donors and FMT recipients (excluding ASVs already present in FMT recipients prior to treatment). The most commonly shared ASVs were classified as Prevotella 9, Peptoclostridium, Bacteroides, Collinsella and unclassified Lachnospiraceae. Lastly, FMT recipients that had recently taken antibiotics exhibited increases in microbiome similarity to an age-matched healthy reference set compared to other cats. Cats that had diarrhea or diarrhea with vomiting became more similar to healthy cats than did cats exhibiting other clinical signs. Overall, our results suggest that oral capsule FMT treatment was effective in this group of cats and microbiome responses may be modulated by the FMT recipient’s initial presenting clinical signs, prior IBD diagnosis, recent antibiotic use, and their diet.

Preprint REVIEW | doi:10.20944/preprints202202.0353.v1

Lactic Acidosis Associated with Metformin in Patients with Diabetic Kidney Disease: A Narrative Review

Fatkhu Rahman, Syahrul Tuba

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Diabetic; Chronic Kidney Disease; Metformin; Acidosis Lactate

Online: 28 February 2022 (09:28:33 CET)

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Working Paper ARTICLE

Gut Microbiota as a Source of Uremic Toxins

Vasily A Popkov, Anastasia A Zharikova, Evgenia A Demchenko, Nadezda V Andrianova, Dmitry B Zorov, Egor Y Plotnikov

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: uremia; uremic toxins; microbiome; chronic kidney disease

Online: 14 July 2021 (13:04:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0577.v1

Association of Edentulism With Various Chronic Diseases in Mexican Elders 60+ Years: Results of a Population-Based Survey

Alejandro José Casanova-Rosado, Juan Fernando Casanova-Rosado, Mirna Minaya-Sánchez, José Luís Robles-Minaya, Juan Alejandro Casanova-Sarmiento, María de Lourdes Márquez-Corona, América Patricia Pontigo-Loyola, Horacio Isla-Granillo, Mariana Mora-Acosta, Sonia Márquez-Rodríguez, Carlo Eduardo Medina-Solís, Gerardo Maupomé

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Oral health; edentulism; chronic diseases; elders; Mexico

Online: 24 March 2021 (11:38:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints201905.0235.v1

The Cost of Chronic Wounds in Argentina: An Estimation of the Burden in a Public Hospital

Romina Chavez-Jara, Nicolas Cerusico, Maria Lazarte, Carla Cabrera, Andrea Herrera Bruno, Eugenia Sesto Cabral, Alberto Nicolas Ramos

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: chronic wound; hospital cost; epidemiology; public health

Online: 20 May 2019 (09:53:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.0845.v1

Linking Migraine to Gut Dysbiosis And Chronic Non-Communicable Diseases

Manuela Di Lauro, Cristina Guerriero, Kevin Cornali, Maria Albanese, Micaela Costacurta, Nicola Biagio Mercuri, Nicola Di Daniele, Annalisa Noce

Subject: Medicine And Pharmacology, Internal Medicine Keywords: migraine; chronic non-communicable diseases; gut microbiota; nutritional approaches; lifestyle changes

Online: 13 September 2023 (10:02:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0681.v1

Using HL7-FHIR as an Integration Platform for Chronic Disease Services Management and Planning in the Irish Healthcare Sector

Vuong M. Ngo, Geetika Sood, Fionnuala Donohue, Patricia Kearney, Claire Buckley, Mark Roantree

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Chronic diseases; Record linkage; Fast healthcare interoperability resources; Federated database

Online: 9 August 2024 (09:38:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0311.v1

Retrospective Cross-Sectional Study on Chronic Hepatitis C in Estonia, Latvia, Lithuania, and Ukraine: Virus, Patient, and Disease Characteristics in Patients under Care (RESPOND-C Study)

Ligita Jančorienė, Baiba Rozentāle, Ieva Tolmane, Agita Jēruma, Riina Salupere, Arida Buivydienė, Jonas Valantinas, Limas Kupčinskas, Jolanta Šumskienė, Eglė Čiupkevičienė, Arvydas Ambrozaitis, Olga Golubovska, Larysa Moroz, Robert Flisiak, Borys Bondar

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Baltic states; chronic hepatitis C; epidemiology; hepatitis C virus; genotype; Ukraine

Online: 5 July 2023 (12:30:04 CEST)

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Background and objectives: Since 2013, highly effective direct-acting (DAA) chronic hepatitis C (CHC) antiviral therapy became available, which has cure rates of over 95%. For choice of optimal CHC treatment, assessment of hepatitis C virus (HCV) genotype (GT) and liver fibrosis stage are necessary. Information about distribution of these parameters among CHC patients in Baltic states and especially in Ukraine is scarce. This study was performed to obtain epidemiological data regarding CHC GT and fibrosis stage distribution for better planning of resources and prioritization of patients for DAA drug treatment according to disease severity in high-income (Baltic states) and lower-middle income (Ukraine) countries. Materials and Methods: This was an epidemiological, retrospective, cross-sectional study that included 1451 CHC patients. Demographic and disease information from medical charts was collected for each patient during a single visit. Results: Most frequent suspected mode of viral transmission was blood transfusions (17.8%), followed by injection drug use (15.7%); however, in 50.9% of patients exact mode of transmission was not clarified. In Ukraine (18.4%) and Estonia (26%) transmission by the injection drug use was higher than in Lithuania (5%) and Latvia (5.3%). Distribution of HCV GT among patients with CHC was as follows: GT1 - 66.4%; GT3 - 28.1; and GT2 - 4.1%. The prevalence of GT1 was the highest in Latvia (84%), and the lowest in Ukraine (63%, p<0.001). Liver fibrosis stages were distributed as follows: F0 - 12.2%, F1 - 26.3%, F2 - 23.5%, F3 – 17.1% and F4 - 20.9%. Cirrhosis (F4) was more prevalent in Lithuanian patients (30.1%) than in Estonians (8.1%, p <0.001). Conclusions: This study contributes to the knowledge of epidemiological characteristics of HCV infection in the Baltic states and Ukraine. The data regarding the patterns of HCV GT and fibrosis stage distribution will be helpful for the development of national strategies to control HCV infection in the era of DAA therapy.

Preprint REVIEW | doi:10.20944/preprints202309.0327.v1

Update on Myocarditis: From Etiology and Clinical Picture to Modern Diagnostics and Methods of Treatment

Ratko Lasica, Lazar Djukanovic, Lidija Savic, Gordana Krljanac, Marija Zdravkovic, Marko Ristic, Andjelka Lasica, Milika Asanin, Arsen Ristic

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: acute myocarditis; chronic inflammatory cardiomyopahty; heart failure; cardiac magnetic resonance; endomyocardial biopsy

Online: 6 September 2023 (02:42:23 CEST)

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Working Paper CONCEPT PAPER

EUROPEAN ME NETWORK (EUROMENE) Expert Consensus on the Diagnosis, Service Provision and Care of People with ME/CFS in Europe

Luis Nacul, Fraçois Jérôme Authier, Carmen Scheibenbogen, Lorenzo Lorusso, Ingrid Helland, Jose Alegre Martin, Carmen Adella Sirbu, Anne Marit Mengshoel, Olli Polo, Uta Behrends, Henrik Nielsen, Patricia Grabowski, Slobodan Sekulic, Nuno Sepulveda., Fernando Esteves Lopez, Pawel Zalewski, Derek Pheby, Jesus Castro-Marrero, Giorgos K Sakkas, Jonas Bergquist, Enrica Capelli, Ivan Brandslund, John Cullinan, Angelika Krumina, Modra Murovska, Ruud Vermuelen, Eliana Lacerda

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome; diagnosis; Health services; clinical care

Online: 16 October 2020 (08:58:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0455.v1

Depression, Anxiety, and Chronic Fatigue Symptoms in Acute Rheumatoid Arthritis are Associated with Immune-inflammatory, Autoimmune, Endogenous Opioid System and Lactosylceramide Signaling Pathways: A Nomothetic Network Approach

Hasan Smesam, Hasan Qazmooz, Sinan Khayoon, Hussein Al-Hakeim, Michael Maes

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: inflammation; neuro-immune; cytokines; major depression; chronic fatigue syndrome; affective disorders

Online: 27 September 2021 (16:30:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0483.v1

Causal Variables in the Association between Physical Well-Being and Chronic Pain: Results from a Cohort Study in Galicia (Northwest Spain)

Roya Karimi, Jesús Prego-Domínguez, Bahi Takkouche

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Chronic pain; confounding; interaction analysis; mediation analysis; physical well-being

Online: 8 May 2023 (08:50:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1018.v1

Management of Short Bowel Syndrome/Chronic Intestinal Failure – the Experience of a Single Portuguese Center

Marisa Domingues Santos, Vânia Magalhães, Luís Loureiro, Pedro Pina, Ana Castro, Paulina Aguiar, Ana Gomes, Diana Soares, Anabela Rocha

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Keywords; Short bowel Syndrome; Chronic Intestinal failure; Home Parenteral Nutrition; Teduglutide; Complications of Parenteral Support

Online: 19 February 2024 (16:24:26 CET)

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Preprint REVIEW | doi:10.20944/preprints202304.1087.v1

Renal Oxygen Demand and Nephron Function: Is Glucose a Friend or Foe?

Edoardo Gronda, Massimo Iacoviello, Alberto Palazzuoli, Manuela Benevenuto, Domenico Gabrielli, Arduino Arduini

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: glucose transport; SGLT2 inhibitor; diabetic nephropathy; heart failure; chronic kidney disease

Online: 28 April 2023 (03:08:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201909.0296.v1

BODE Index Correlated with Charlson Comorbidity Index and Medical Burden in COPD

Li Chin Ling, Lin Mei-Hsin, Tsai Yuh-Chyn, Chen Pei-Shiuan, Shen Lien-Shi, Kuo Ho-Chang, Liu Shih-Feng

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: chronic obstructive pulmonary disease; bode index; charlson comorbidity index; medical burden

Online: 26 September 2019 (09:58:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0653.v1

Cholinergic Stimulation Exerts Cardioprotective Effects and Alleviates Renal Inflammatory Responses after Acute Myocardial Infarction in Spontaneous Hypertensive Rats (SHRs)

Pamela Nithzi Bricher Choque, Maria Helena Porter, Manuella da Silva Teixeira, Humberto Dellê, Rosilene Motta Elias, Bruno Durante, Marina Rascio Henriques Dutra, Christine N. Metz, Valentin A. Pavlov, Fernanda M. Consolim Colombo

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: acute myocardial infarction; cardiorenal syndrome; chronic kidney injury; Inflammation; autonomic nervous system; cholinergic stimulation; pyridostigmine bromide; vagus nerve

Online: 12 March 2024 (09:09:59 CET)

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Preprint REVIEW | doi:10.20944/preprints202407.0119.v1

Evaluating the Anti-cancer Potential of Ganoderma lucidum: A Critical Analysis of Clinical Evidence and Methodological Advances

Iyingiala Austin-Asomeji, Morufu Olalekan Raimi, Emem Okon Mbong, Adenike Bosede Ariyo, Fubara Gift Evans, Emmanuel Green Ekine, Abdulsalam Ridwan Rotimi, Karibi Eralei Ibere, Salisu Lawan, Augustine Chimeebere Onugha, Oghenerhoro Simeon Ajueyitsi, Sandra Nonyerem Bunmi Ukoh, Esther Omone Akhigbe

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Medicinal mushrooms Chronic disorders; Clinical studies; Anti-cancer properties; Methodological excellence; Products generated from mushrooms; Dietary supplements; The regulatory structure.

Online: 1 July 2024 (18:00:19 CEST)

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Rationale: A wide range of bioactive phytoconstituents from edible fungi, especially therapeutic mushrooms, have the potential to improve health, especially in the case of chronic illnesses. Known for its anti-cancer qualities, ganoderma lucidum has been the focus of multiple clinical studies. Existing systematic reviews imply that more clinical research and methodological refinement are necessary to support its usage as a primary cancer treatment.Objective: The objective of this research is to evaluate the anti-cancer potential of the bioactive phytoconstituents found in mushrooms, specifically Ganoderma lucidum, in a thorough manner. The aim is to conduct a critical assessment of the extant literature, pinpoint any deficiencies, and offer valuable perspectives on the methodological excellence and research requirements in this domain.Method(s): A thorough analysis of published clinical trials was carried out, with a focus on studies that examined the effectiveness of Ganoderma lucidum and other products derived from mushrooms in treating cancer. The study's design, stated results, and methodological rigor were all carefully examined to evaluate the validity and reliability of the conclusions.Results: Despite Ganoderma lucidum's potential against cancer, the evaluation finds insufficient data to support its widespread usage as a primary cancer treatment. Products made from mushrooms, which are frequently sold as dietary supplements, have anti-cancer claims. But since pre-approval is not required under US regulatory framework in order to market food supplements, these statements raise questions regarding their scientific validity.Conclusions/Recommendations: The study's result emphasizes the necessity of more methodological advancement in clinical studies examining Ganoderma lucidum's potential as an anti-cancer agent. It also highlights the significance of thorough scientific validation for goods made from mushrooms that make health claims. To establish accurate claims regarding their anti-cancer effects, recommendations include developing technological methods for the purification of bioactive substances and undertaking thorough studies of mushroom products from different geographical regions. The goal of this thorough analysis is to direct future investigations and support the ethical promotion and use of products derived from mushrooms for medical purposes.

Preprint REVIEW | doi:10.20944/preprints202109.0511.v1

Oxygen, pH, Lactate, and Metabolism- How Old Knowledge and New Insights Might be Combined for New Wound Treatment

Herbert Leopold Haller, Frank Sander, Sebastian Philipp Nischwitz, Daniel Popp, Matthias Rapp, Bernd Hartmann, Mehmet Demircan, Lars Peter Kamolz

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Wound; chronic wound; hypoxia; Lactate; Acidosis; Alkalosis; neoangiogenesis; ECM; Polylactide; polylactide membranes

Online: 30 September 2021 (12:18:52 CEST)

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: Over time, we have come to recognize a very complex network of physiological changes enabling wound healing. An immunological process enables the body to distinguish damaged cells and begin a cleaning mechanism by separating damaged proteins and cells with matrix metallopro-teinases, a complement reaction, and free radicals. A wide variety of cell functions help to rebuild new tissue, dependent on energy provision and oxygen supply. Like in an optimized "biorector," disturbance can lead to prolonged healing. One of the earliest investigated local factors is the pH of wounds, studied in close relation to the local perfusion, oxygen tension, and lactate concentration. Granulation tissue with the wrong pH can hinder fibroblast and keratinocyte division and pro-liferation, as well as skin graft takes. Methods for influencing the pH have been tested, such as occlusion and acidification by the topical application of acidic media. In most trials, this has not changed the wound's pH to an acidic one, but it has reduced the strong alkalinity of deeper or chronic wound. Energy provision is essential for all repair processes. New insights into the metabolism of cells have changed the definition of lactate from a waste product to an indispensable energy provider in normoxic and hypoxic conditions. Neovascularization depends on oxygen provision and lactate, signaling hypoxic conditions even under normoxic conditions. An appropriate pH is necessary for successful skin grafting; hypoxia can change the pH of wounds. This review describes the close interconnections between the local lactate levels, metabolism, healing mechanisms, and pH. Furthermore, it analyzes and evaluates the different possible ways to support metabolism, such as lactate enhancement and pH adjustment. The aim of wound treatment must be the optimization of all these components. Therefore, the role of lactate and its influence on wound healing in acute and chronic wounds will be assessed.

Preprint REVIEW | doi:10.20944/preprints202009.0706.v1

A New Endemic of Concomitant Nonalcoholic Fatty Liver Disease and Chronic Hepatitis B

Hira Hanif, Muzammil Khan, Mukarram Ali, Pir Shah, Jinendra Satiya, Daryl Lau, Aysha Aslam

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Chronic hepatitis B; NAFLD; NASH; biomarkers; magnetic resonance technology; NAFLD therapy

Online: 29 September 2020 (10:40:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0101.v1

Association between Neuropathic Pain Characteristics and DNA Methylation of TRPA1 in Human Peripheral Blood

Shiho Takenaka, Norihiko Sukenaga, Mai Imasaka, Masaki Ohmuraya, Yuka Matsuki, Lynn Maeda, Yumiko Takao, Munetaka Hirose

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: chronic pain; epigenetics; neuropathic pain; postoperative pain; thoracic surgery; video-assisted

Online: 10 November 2019 (09:29:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202008.0728.v1

Cellular and Molecular Mechanisms of CD8+ T Cell Differentiation, Dysfunction and Exhaustion

Daniel J Verdon, Matthias Mulazzani, Misty R Jenkins

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: T cell exhaustion; chronic viral infections; cancer; immunotherapy; epigenetics; PD-1; inhibitory receptors

Online: 31 August 2020 (17:49:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0604.v1

People-Centeredness, Chronic Conditions and Diversity Sensitive eHealth: Exploring Emancipation of the ‘Health Care System’ and the ‘Patient’ in Health Informatics

Lars Botin, Pernille S. Bertelsen, Christian Nøhr

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: eHealth; end-user; chronic disease; participatory design; socio-technical; diversity in care

Online: 29 October 2020 (09:30:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints201909.0043.v3

An Isolated Complex V Inefficiency and Dysregulated Mitochondrial Function in Immortalized Lymphocytes from ME/CFS Patients

Daniel Missailidis, Sarah Annesley, Claire Allan, Oana Sanislav, Brett Lidbury, Donald Lewis, Paul Fisher

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Myalgic Encephalomyelitis; Chronic Fatigue Syndrome; mitochondria; Complex V; TORC1; Seahorse respirometry

Online: 3 February 2020 (09:34:29 CET)

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Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is an enigmatic condition characterized by exacerbation of symptoms after exertion (post-exertional malaise or “PEM”), and by fatigue whose severity and associated requirement for rest are excessive and disproportionate to the fatigue-inducing activity. There is no definitive molecular marker or known underlying pathological mechanism for the condition. Increasing evidence for aberrant energy metabolism suggests a role for mitochondrial dysfunction in ME/CFS. Our objective was therefore to measure mitochondrial function and cellular stress sensing in actively metabolising patient blood cells. We immortalized lymphoblasts isolated from 51 ME/CFS patients diagnosed according to the Canadian Consensus Criteria and an age- and gender-matched control group. Parameters of mitochondrial function and energy stress sensing were assessed by Seahorse extracellular flux analysis, proteomics, and an array of additional biochemical assays. As a proportion of the basal oxygen consumption rate (OCR), the rate of ATP synthesis by Complex V was significantly reduced in ME/CFS lymphoblasts, while significant elevations were observed in Complex I OCR, maximum OCR, spare respiratory capacity, nonmitochondrial OCR and “proton leak” as a proportion of the basal OCR. This was accompanied by a reduction of mitochondrial membrane potential, chronically hyperactivated TOR Complex I stress signalling and upregulated expression of mitochondrial respiratory complexes, fatty acid transporters and enzymes of the β-oxidation and TCA cycles. By contrast, mitochondrial mass and genome copy number, as well as glycolytic rates and steady state ATP levels were unchanged. Our results suggest a model in which ME/CFS lymphoblasts have a Complex V defect accompanied by compensatory upregulation of their respiratory capacity that includes the mitochondrial respiratory complexes, membrane transporters and enzymes involved in fatty acid β-oxidation. This homeostatically returns ATP synthesis and steady state levels to “normal” in the resting cells, but may leave them unable to adequately respond to acute increases in energy demand as the relevant homeostatic pathways are already activated.

Preprint REVIEW | doi:10.20944/preprints202210.0142.v1

Employ of Anthocyanins in nanocarriers for Nano Delivery: In Vitro and In Vivo Experimental Approaches for Chronic Diseases

Ana C. Gonçalves, Amícal Falcão, Gilberto Alves, João A. Lopes, Luís R. Silva

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: bioactive compounds; anthocyanins; drug delivery system; nanoparticles; chronic diseases; health benefits

Online: 11 October 2022 (05:04:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.2138.v1

A Synopsis of Hepatitis C Virus Treatments and Future Perspectives

Christian Medina, Alexis Hipolito Garcia, Francis Isamarg Crespo, Felix Isidro Toro, Soriuska José Mayora, Juan Bautista De Sanctis

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Hepatitis C virus; chronic HCV; antivirals; Sustained virological response; IFN therapy; Vaccines

Online: 30 September 2023 (05:39:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.1805.v1

VACCINATON POLICIES IN SOLID ORGAN TRANSPLANT ADULT CANDIDATES AND RECIPIENTS

Mauro Viganò, Marta Beretta, Marta Lepore, Raffaele Abete, Simone Vasilij Benatti, Maria Vittoria Grassini, Stefania Camagni, Greta Chiodini, Simone Vargiu, Claudia Vittori, Marco Iachini, Amedeo Terzi, Flavia Neri, Domenico Pinelli, Fabiano Di Marco, Piero Ruggenenti, Marco Rizzi, Michele Colledan, Stefano Fagiuoli

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: solid organ transplantation; vaccination; chronic diseases; liver; lungs; heart; kidney; infections; prevention.

Online: 26 July 2023 (11:15:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0182.v1

In Schizophrenia, Chronic Fatigue Syndrome- and Fibromyalgia-Like Symptoms are Driven by Breakdown of the Paracellular Pathway with Increased Zonulin and Immune Activation-Associated Neurotoxicity

Michael Maes, Laura Andrés-Rodríguez, Aristo Vojdani, Sunee Sirivichayakul, Décio Barbosa, Buranee Kanchanatawan

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: chronic fatigue syndrome; Myalgic encephalomyelitis; oxidative stress; neuro-immune; inflammation; bacterial translocation

Online: 10 May 2021 (12:27:45 CEST)

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