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Preprint REVIEW | doi:10.20944/preprints202008.0166.v1

Antibody Response and Therapy in COVID-19 Patients: Significance in Vaccine Development

Ligong Lu, Hui Zhang, Meixiao Zhan, Jun Jiang, Hua Yin, Danielle J. Dauphars, Shi-You Li, Yong Li, You-Wen He

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19, seroconversion, neutralizing antibody, spike protein, SARS-CoV-2, convalescent plasma, vaccine

Online: 6 August 2020 (12:16:11 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202004.0269.v1

Antibiotics Against COVID-19 and Mitochondria? Urgent Thinking Out of the Box

Jaroslaw Tyszka, Karolina Kobos, Aleksandra Tyszka

Subject: Chemistry And Materials Science, Theoretical Chemistry Keywords: COVID-19; SARS-CoV-2; pandemic; antibiotics; immune response; mitochondria; epidemiology; health policy

Online: 16 April 2020 (12:14:30 CEST)

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Italian, Spanish, French vs German, Austrian or Norwegian COVID-19 tracks? Antibiotics might have a partial impact on COVID-19 death rates in various countries. Our working hypotheses based on recent publications is that that antibiotics may be a major factor that negatively affects patients’ immune system during viral infections. We are all aware that there is no specific and effective medical treatment for COVID-19 so far. However, we know that our immune system is the only efficient weapon that fights against this syndrome right now. In fact, antibiotics are very often prescribed to prevent secondary infections following an antiviral immune response. Various antibiotic therapies have also been commonly applied to support COVID-19 treatments in China and Italy. Unfortunately, the frequent antibiotic off-site targets include mitochondria that are genetically and evolutionary closely linked to bacteria. Mitochondria are multifunctional organelles responsible for bioenergetics in nearly all our cells, acting as signaling hubs in antiviral and antibacterial immune responses. Several studies have demonstrated that mitochondria are vulnerable to antibacterial treatments, interrupting their physiology. Inhibition of these processes by antibiotics might render the immune system less capable of fighting acute COVID-19 viral infections. Some antibiotics, including those prescribed for COVID-19 in Wuhan, have been shown to inhibit the synthesis of mitochondrial DNA. The question is whether antibiotics support such a treatment or weaken patient immune responses in this case. This hypothesis should be evaluated based on comparative clinical data that seem to be unavailable at the moment. Possibly the COVID-19 risk group should be extended to all patients being treated with antibiotics, including those who finished antibiotic therapies days up to several months before SARS-CoV-2 infection. We therefore urge health service response groups to evaluate the impact of antibiotics on COVID-19 recovery vs death retrospective data. We would like to motivate international, national and local health authorities to share available clinical treatment data, discuss and optimize treatment strategies.

Preprint ARTICLE | doi:10.20944/preprints202307.0107.v2

Group Theory of Messenger RNA Metabolism and Disease

Michel Planat, Marcelo Amaral, Fang Fang, David Chester, Raymond Aschheim, Klee Irwin

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: RNA metabolism; micro-RNAs; diseases; finitely generated group; SL(2,C) character variety; aperiodicity

Online: 23 October 2023 (11:16:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0381.v1

Efficacy of Licensed Monoclonal Antibodies and Antiviral Agents against the SARS-CoV-2 Omicron Sub-Lineages BA.1 and BA.2

Lia Fiaschi, Filippo Dragoni, Elisabetta Schiaroli, Annalisa Bergna, Barbara Rossetti, Federica Giammarino, Camilla Biba, Anna Gidari, Alessia Lai, Cesira Nencioni, Daniela Francisci, Maurizio Zazzi, Ilaria Vicenti

Subject: Biology And Life Sciences, Virology Keywords: Sars-Cov-2; mAbs; Paxlovid; Remdesivir; Molnupiravir; Microneutralization assay; Cell-based assay; Omicron sublineages

Online: 27 May 2022 (10:45:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0002.v1

Candida Variety in the Oral Cavity of Mexican Subjects with Type 2 Diabetes Mellitus and TLR2 Gene Expression

NADIA MABEL PEREZ VIELMA, MODESTO GÓMEZ LÓPEZ, MARÍA DE LOS ANGELES MARTÍNEZ GODÍNEZ, ANA LAURA LUNA TORRES, AARÓN DOMÍNGUEZ LÓPEZ, ANGEL MILIAR GARCÍA

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Candida, type 2 diabetes mellitus, PAP stain, oral cavity, molecular diagnosis, TLR2

Online: 1 February 2024 (09:32:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1486.v1

Antiviral Efficacy of Heparan Sulfate and Enoxaparin Sodium against SARS-CoV-2: An In-Vitro/in-Silico Model

Virginia Fuochi, Salvatore Furnari, Giuseppe Floresta, Vincenzo Patamia, Chiara Zagni, Filippo Drago, Antonio Rescifina, Pio Maria Furneri

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: heparan sulfate; enoxaparin; coronavirus; SARS-CoV-2; ACE2, absorption inhibition; molecular docking

Online: 24 October 2023 (08:12:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1131.v1

Inflammatory Biomarker Profiles in Very Preterm Infants within the Context of Preeclampsia, Chorioamnionitis and Clinically Diagnosed Postnatal Infection

Jordan T. Ewald, Baiba Steinbrekera, Jennifer R. Bermick, Donna A. Santillan, Tarah T. Colaizy, Mark K. Santillan, Robert D. Roghair

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: adipokine; chemokine (C-C motif) ligand 2; interleukin-6; leptin; neonatal; preeclampsia

Online: 16 May 2023 (09:00:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0190.v2

Fusarium Culmorum Produces NX-2 Toxin Simultaneously With Deoxynivalenol and 3-Acetyl-Deoxynivalenol or Nivalenol (Submitted to Toxins)

Simon Schiwek, Mohammad Alhussein, Charlotte Rodemann, Tuvshinjargal Budragchaa, Lukas Beule, Andreas von Tiedemann, Petr Karlovsky

Subject: Biology And Life Sciences, Toxicology Keywords: NX-2; NX toxins; Fusarium culmorum; 3-actyl-deoxynivalenol; nivalenol; trichothecenes; chemotype

Online: 20 June 2022 (04:41:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0044.v1

Signatures of the Venezuelan Humanitarian Crisis in the First Wave of COVID-19: Fuel Shortages and Border Migration

Margarita Lampo, Juan Vicente Hernández-Villena, Jaime Cascante, María Fernanda Vicenti-González, David A. Forero-Peña, Maikell J. Segovia, Katie Hampson, Julio Castro, Maria Eugenia Grillet

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: SEI models; metapoplations; Venezuela; SARS-CoV-2; drivers of transmission; spatial incidence.

Online: 1 June 2021 (15:18:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0234.v1

Physical Analysis of SARS-CoV-2 Routes: from Primary Production and Emissions to Exposures and COVID-19 Infection

Gjalt Huppes, Ruben Huele

Subject: Biology And Life Sciences, Biophysics Keywords: SARS-CoV-2; COVID-19; virions mass balance; spatial modelling of toxics concentrations; human exposure to airborne substances; Substance Flow Analysis (SFA); environmental routes of toxic viruses; primary production of SARS-2 virions

Online: 17 May 2022 (14:19:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0745.v1

Hepatic Steatosis is Generated by the Gut Microbiota-Mitochondria Axis via 2-oleolyl Glycerol and Reverted by Functional Foods

Mónica Sánchez-Tapia, Sandra Tobón-Cornejo, Lilia G Noriega, Natalia Vázquez, Diana Coutiño-Hernández, Omar Granados-Portillo, Berenice M Román-Calleja, Astrid Ruiz-Margáin, Ricardo U Macías-Rodríguez, Armando R. Tovar, Nimbe Torres

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: hepatic steatosis; functional foods; gut microbiota; 2-Oleoyl glycerol; mithochondria function; ROS

Online: 10 July 2024 (04:52:30 CEST)

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Metabolic dysfunction-associated steatotic liver disease (MASLD) is a serious health problem, and recent evidence indicates that gut microbiota plays a key role in its development. It is known that 2-oleoyl glycerol (2-OG) produced by the gut microbiota is associated with hepatic fibrosis, but it is not known whether this metabolite is involved in the development of hepatic steatosis. The aim of this study was to evaluate how a high-fat sucrose diet (HFS) increases 2-OG production through gut microbiota dysbiosis and to identify whether this metabolite modifies hepatic lipogenesis and mitochondrial activity for the development of hepatic steatosis as well as whether a combination of functional foods can reverse this process. Wistar rats were fed HFS diet for 7 mo. At the end of the study, body composition, biochemical parameters, gut microbiota, protein abundance of lipogenic and antioxidant enzymes, measurement of liver 2-OG, and mitochondrial function were assessed in rats and we studied the effect of HFS with functional foods. In humans with MASLD, we analyzed gut microbiota and serum 2-OG. Consumption of HFS diet in Wistar rats caused oxidative stress, hepatic steatosis and gut microbiota dysbiosis, decreasing α-diversity and increased Blautia producta abundance, which increased 2-OG. This metabolite increased de novo lipogenesis through ChREBP and SREBP-1. 2-OG significantly increased mitochondrial dysfunction. Addition of functional foods to the diet modified the gut microbiota, reducing B. producta and 2-OG levels, leading to a decrease in body weight gain, body fat mass, serum glucose, insulin, cholesterol, triglycerides, fatty liver formation, and increased mitochondrial function. In order to use 2-OG as biomarker, this metabolite was measured in healthy subjects or with MASLD and it was observed that subjects with hepatic steatosis II and III had significantly higher 2-OG than healthy subjects, suggesting that the abundance of this circulating metabolite could be a predictor marker of hepatic steatosis.

Preprint REVIEW | doi:10.20944/preprints202307.0627.v1

Suffocation in asthma and COVID-19: Supplementation of inhaled corticosteroids with alkaline hydrogen peroxide as an alternative to ECMO

Aleksandr Urakov, Natalya Urakova, Petr Shabanov, Roman Rozov, Anatoly Osipov, Aleksandr Samorodov, Ilnur Yagudin, Darya Suntsova, Nikita Muhundinov, Anastasia Stolyarenko

Subject: Medicine And Pharmacology, Emergency Medicine Keywords: oxidative stress; antioxidant; infalammation; SARS-CoV-2; COVID-19; asthma; anti-inflammatory.

Online: 11 July 2023 (02:09:43 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202008.0519.v1

Brief Report: Rapid Clinical Recovery from Severe COVID-19 with High Dose Famotidine and High Dose Celecoxib Adjuvant Therapy

kevin tomera, joseph kittah

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: SARS-CoV-2, COVID-19, Acute Respiratory Distress Syndrome, ARDS, Famotidine, Celecoxib

Online: 24 August 2020 (09:46:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0144.v1

Chemo-Stratigraphy, Petrology and U-Pb Geochronology of Karakılıçlı Volcanic Field in NW Anatolia: Implications for Hellenic Subduction System

Ali İskenderoğlu, NAMIK AYSAL

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: Western Anatolia 1; Geochronology 2; slab roll-back 3; Hellenic slab 4.

Online: 6 August 2020 (09:54:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0244.v1

Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q⁵⁸-K⁵⁹ Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities

Stefan Sikorra, Martin Skiba, Martin B. Dorner, Jasmin Weisemann, Mirjam Weil, Sylvia Valdezate, Bazbek Davletov, Andreas Rummel, Brigitte G. Dorner, Thomas Binz

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Clostridium botulinum; botulinum neurotoxin; serotype F; subtype; VAMP-2; synaptobrevin; Zn2+ protease

Online: 15 June 2018 (05:32:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1394.v1

Molecular Characterization and Genomic Surveillance of SARS-CoV-2 Lineages in Central India

Purna Dwivedi, Mukul Sharma, Afzal Ansari, Arup Ghosh, Subasa Chandra Bishwal, Suman Kumar Ray, Manish Katiyar, Kombiah Subbiah, Lalit Sahare, Mahendra Ukey, Pradip Barde, Aparup Das, Pushpendra Singh

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; Genetic diversity; Whole genome sequencing; Phylogenetic tree; COVID-19; Transmission

Online: 21 June 2024 (05:04:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0076.v1

Molecular Docking and Dynamics Identifies Potential Repurposed Drug Candidates for COVID-19 Studies

Mohammed Muzaffar-Ur-Rehman, Chougule Suryakant, Ala Chandu, Banoth Kumar, Renuka Joshi, Snehal Jadhav, Sankaranarayanan Murugesan, Seshadri Vasan

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: COVID-19; drug repurposing; long COVID; molecular docking; molecular dynamics; SARS-CoV-2

Online: 4 January 2023 (09:38:47 CET)

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Preprint REVIEW | doi:10.20944/preprints202206.0022.v1

Immune Escape Associated with RBD Omicron Mutations and SARS-CoV-2 Evolution Dynamics

Alexander Kudryavtsev, Anna V. Vakhrusheva, Valery Novoseletsky, Marine Bozdaganyan, Konstantin V. Shaitan, Mikhail P. Kirpichnikov, Olga S. Sokolova

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; COVID-19; Omicron; bioinformatics; immune escape; RBD mutations; vaccine development

Online: 1 June 2022 (14:12:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0197.v1

Theoretical Explanation for Reduced Body Mass Index and Obesity Rates in Cannabis Users

Thomas Clark, Jessica Jones,, Alexis Hall, Sara Tabner, Rebecca Kmiec

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Cannabis, obesity, body mass index, CB1R, AEA, 2-AG, meta-analysis, theory, causation

Online: 11 July 2018 (11:49:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.0563.v1

Sex, Age, and Risk Groups Variations among Individuals Infected with HIV, HTLV-1, and HTLV-2: Review of Data Records (1983–2017) from a Public Health Laboratory in São Paulo, Brazil

Adele Caterino-de-Araujo

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: HIV; HTLV-1; HTLV-2; sex; risk factors; prevalence; co-infection; public policies

Online: 8 September 2023 (09:39:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0225.v2

COVID-19: Considerations for Children and Adolescents with Diabetes

Devi Dayal

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Coronavirus disease 2019; COVID-19; children; diabetes; type 1 diabetes; type 2 diabetes; recommendations

Online: 15 May 2020 (04:54:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1394.v1

Evaluation of the Relationship between CRP/Lymphocyte Ratio and Blood Sugar Regulation and Other Metabolic Parameters in Patients with Type 2 Diabetes Mellitus

Tugrul Sagdic, Gulali Aktas

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: type 2 diabetes mellitus (T2DM); c-reactive protein (CRP); CRP/lymphocytes (CLR); inflammation; biomarker

Online: 21 September 2023 (04:29:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0809.v1

SARS-CoV-2 Detection and Culture in Different Biological Specimens from Immunocompetent and Immunosuppressed COVID-19 Patients Infected with Two Different Viral Strains

Maria Cassia Mendes-Correa, Matias Chiarastelli Salomão, Fabio Ghilardi, Tania Regina Tozetto-Mendoza, Lucy Santos Vilas Boas, Anderson Vicente De Paula, Heuder Gustavo Oliveira Paiao, Antonio Charlys Da Costa, Fabio Eudes Leal, Andrea de Barros Coscelli Ferraz, Flavia Cristina Salles, Ingra M. Claro, Noely Evangelista Ferreira, Geovana M. Pereira, Almir Ribeiro Junior, Wilton Freire, Evelyn Patricia Sánchez Espinoza, Erika R. Manuli, Camila Romano, Jaqueline Goes De Jesus, Ester Cerdeira Sabino, Steven Sol Witkin

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: SARS CoV 2; infectiousness; cell culture; viral shedding; viral load dynamics; persistence; Covid-19

Online: 24 April 2023 (03:07:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0016.v1

The Impact of Perceived Hapkido Service Quality on Exercise Continuation and Recommendation Intentions, with a Focus on Korean Middle and High School Students

Tae-Seung Park, Jun-Su Kim, Jiyoun Kim

Subject: Physical Sciences, Biophysics Keywords: keyword 1; Hapkido 2; Service Quality 3; Quality on Exercise Continuation 4; Recommendation Intentions

Online: 1 March 2021 (13:37:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.2036.v1

Evaluation of Incidence of Respiratory Syncytial Virus, SARS-CoV-2, Influenza A/B, and Adenovirus Cases via Rapid Tests in Community during the Winter 2023 Season. A Cross Sectional Study

Dimitrios Papagiannis, Garyfallia Perlepe, Theodora Tendolouri, Polyxeni Karakitsiou, Georgia Damagka, Anna Kalaitzi, Sofia Alevra, Foteini Malli, Konstantinos I. Gourgoulianis

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: RSV; SARS-CoV-2; Influenza A/B; adenovirus; rapid test; Vaccinations

Online: 31 July 2023 (04:17:26 CEST)

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Respiratory infections constitute a major reason for infants and children seeking medical advice and visiting health facilities, thus remaining a significant public threat with high morbidity and mortality. The predominant viruses causing viral respiratory infections are influenza A and B viruses (Flu-A, Flu-B), Respiratory Syncytial Virus (RSV), Adenovirus and Coronaviruses. We aimed to record the incidence of RSV, SARS-CoV-2, Influenza A/B and Adenovirus cases with rapid antigen tests and validate the results with RT-PCR assay of upper respiratory specimens with a wide range of viral loads and (co)-infection patterns in children. Clinical samples were collected from early symptomatic children (presenting with fever and/or cough and/or headache within 5–7 days). The surveillance program was conducted in five private pediatrician dispensaries and one Pediatric care unit, from 10 January 2023 to 30 March 2023 in central Greece. The total sample of specimens collected was 784 young children and infants, of which 383 (48.8%) ware female and 401 were male (51.2%). The mean age of participants was 7.3 + 5.5 years. The sensitivity of FLU A & B test was 91.15% (95% CI: 84.33% -95.67%), and the specificity was 98.96% (95% CI: 97.86% - 99.58%). The sensitivity and specificity of the adenovirus and RSV test was {92.45% (95% CI: 81.79% - 97.91%), 99.32% (95% CI: 98.41% -99.78%)} and {92.59% (95% CI: 75.71% -99.09%), 99.47% (95% CI: 98.65% - 99.86%)} respectively. Lastly, the sensitivity of the SARS-CoV-2 test was 100.00% (95% CI: 79.41%-100.00%) and the specificity was 99.74% (95% CI: 99.06% - 99.97%). We recorded proportion of incidence for the Influenza-A and B, (14.3%), - (3.44%) correspondingly, followed by the adenovirus with a proportion (6.9%) and the RSV with (3.7%) incidence proportion and finally, the SARS-CoV-2 (2.3%). The combination of a new multiple rapid test with multiple antigens, will be probably a useful tool with financial impact for health systems targeting the early detection and right treatment of respiratory infections in the emergency departments in primary health care facilities.

Preprint REVIEW | doi:10.20944/preprints201810.0428.v1

Is the Response of Tumours Dependent on Dietary Input of Some Amino Acids or on the Ratios Among Essential and Non-Essential Amino Acids? All That Glisters is Not Gold

Francesco Dioguardi, Vincenzo Flati, Giovanni Corsetti, Evasio Pasini, Claudia Romano

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: amino acids, cancer, energy metabolism, autophagy, apoptosis, glutamine, diabetes type 2.

Online: 18 October 2018 (16:45:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202003.0197.v3

2019 Novel Coronavirus (COVID-19) Pandemic: Built Environment Considerations To Reduce Transmission

Leslie Dietz, Patrick F. Horve, David Coil, Mark Fretz, Jonathan Eisen, Kevin Van Den Wymelenberg

Subject: Biology And Life Sciences, Virology Keywords: Built Environment (BE); building operations; novel coronavirus; COVID-19; SARS-CoV-2

Online: 2 April 2020 (05:19:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0202.v1

Crop Detection Using Time Series of Sentinel-2 and Sentinel-1 and Existing Land Parcel Information Systems

Herman Snevajs, Karel Charvat, Vincent Onckelet, Jiri Kvapil, Frantisek Zadrazil, Hana Kubickova, Jana Seidlova, Iva Bartlova

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: crop detection; Sentinel 1; Sentinel 2; supervised classification; unsupervised classification; time series; agriculture; food security

Online: 14 January 2022 (11:18:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0404.v2

Early Lesion of Post-Primary Tuberculosis: Subclinical Driver of Disease and Target for Vaccines and Host-directed Therapies

Robert E. E. Brown, Robert L Hunter

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: tuberculosis; secretory antigens; bronchiolar epithelium; alveolar pneumocytes; M2 polarization; COX-2, FAS; Pathogenesis; early lesion

Online: 29 September 2021 (09:56:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0120.v1

Investigating Various Products of IMERG for Precipitation Retrieval Over Surfaces With and Without Snow and Ice Cover

Alireza Arabzadeh, Ali Behrangi

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: IMERG; Stage IV; Infrared; Passive microwave; Snow; Ice; Precipitation; GPM; Wet-bulb temperature; AMSR-2

Online: 3 June 2021 (14:59:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0158.v2

Mapping the Accessory Proteins (Orfs) of Severe Acute Respiratory Syndrome Coronavirus 2

Sunil Thomas

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: severe acute respiratory syndrome coronavirus 2; SARS-CoV-2; COVID-19; accessory protein; mapping; structure; Open reading frame, Orf.

Online: 3 November 2022 (10:27:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202208.0110.v1

Cytoprotective Activity of Newly Synthesized 3-(arylmethyl)-6-methyl-4-phenylpyridin-2(1H)-ones derivatives

Shynggys Sergazy, Zarina Shulgau, Aigerim Zhulikeyeva, Yerlan Ramankulov, Irina V. Palamarchuk, Ivan V. Kulakov

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: 3-aminopyridin-2(1H)-one derivatives; 3-(arylmethyl)-6-methyl-4-phenylpyridin-2(1H)-ones; antiradical activity; cytoprotective activity

Online: 4 August 2022 (14:12:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0161.v1

The Small Intestine, an Underestimated Site of SARS-CoV-2 Infection: From Red Queen Effect to Probiotics

Zhijie Feng, Yan Wang, Wei Qi

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: coronaviruses receptors; angiotensin-converting enzyme 2 (ACE2); COVID-19; SARS-Cov-2; the Red Queen hypothesis; segmented filamentous bacteria

Online: 10 March 2020 (08:45:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.1815.v1

An Integrated Approach Based on Clinical Data Together with Metabolites and Biomarkers for the Assessment of the Postoperative Complications after Cardiac Surgery

Peter Meinarovich, Alisa Pautova, Evgenii Zuev, Ekaterina Sorokina, Ekaterina Chernevskaya, Natalia Beloborodova

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: aromatic microbial metabolites; sepsis-associated metabolites; 4-hydroxyphenyllactic acid; prognostic models; SOFA

Online: 23 July 2024 (16:04:39 CEST)

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Background: Early diagnosis of postoperative complications is an urgent task, allowing timely prescribing of appropriate therapy and reducing the cost of patient treatment. Prognostic models based on various data could help in the early diagnosis of postoperative complications after cardiac surgery. Objectives: The purpose of the study was to determine whether an integrated approach based on clinical data along with metabolites and biomarkers had greater predictive value than the models built on less data. Methods: The study included patients (n=62) admitted for planned cardiac surgery (coronary artery bypass grafting with cardiopulmonary bypass), who were retrospectively divided into two groups depending on the presence (n=26) or absence (n=36) of postoperative complications of all types. Clinical and laboratory data on the first day after surgery were analyzed. Additionally, patients' blood samples were collected before and on the first day after surgery to determine biomarkers (interleukin-6, procalcitonin, NT-proBNP, high-sensitivity troponin T) and metabolites (8 aromatic and 2 dicarboxylic acids were detected using gas chromatography-mass spectrometry). Results: Patients before surgery, compared with healthy donors, differed in the concentration of metabolites (p < 0.05), and had concentrations of a number of biomarkers exceeding the corresponding reference values. Multivariate PLS-DA models, predicting the presence or absence of postoperative complications, were built using clinical data (ROC-AUC=0.71), concentrations of metabolites and biomarkers (ROC-AUC=0.60), and the entire data set (ROC-AUC=0.75). For comparison we built univariate models using the EuroScore2 (ROC-AUC=0.59) and SOFA (ROC-AUC=0.76) scales; concentrations of lactate (ROC-AUC=0.71), the dynamic changes of 4-hydroxyphenyllactic acid (ROC-AUC=0.69), and the sum of three sepsis-associated metabolites (ROC-AUC=0.70). The proposed complex model using entire data set was comparable to the SOFA scale, which confirms the expediency of searching for new predictive models based on a variety of factors.

Preprint ARTICLE | doi:10.20944/preprints202307.0134.v1

Modeling and Visualizing the Dynamics of Epidemic Diseases Spread. The Case of COVID-19

Loukas Zachilas, Christos Benos

Subject: Physical Sciences, Biophysics Keywords: COVID-19; SARS-CoV-2; epidemiology; lattice simulation; infection diffusion; epidemics; control measures

Online: 4 July 2023 (03:58:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0530.v1

ISIDOG Consensus Guidelines on Covid-19 Vaccination for Women before, during and after Pregnancy

Gilbert Gerard Ghislain Donders, Svitrigaile Grinceviciene, Kai Haldre, Risa Lonnee-Hofmann, Francesca Donders, Aristotelis Tsiakalos, Albert Adriaanse, Jose Martinez de Oliveira, Kevin Ault, Werner Mendling

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: vaccine, pregnancy complication, SARS-CoV-2, COVID-19, maternal complications, pandemic, prevention, safety

Online: 20 April 2021 (11:22:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0092.v1

Relationships between Urine Albumin Excretion and Dietary Habits in Patients with Type 2 Diabetes

Sadako Matsui, Yasuhisa Someya, Hiroshi Yoshida

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Type 2 diabetes; urea albumin excretion; food frequency questionnaire survey; β-cryptoxanthin; fruits

Online: 8 July 2019 (14:44:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1501.v1

Analysing the Cyanobacterial PipX Interaction Network Using NanoBiT Complementation in Synechococcus elongatus PCC7942

Carmen Jerez, Antonio Llop, Paloma Salinas, Sirine Bibak, Karl Forchhammer, Asunción Contreras

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: NanoLuc; PII; NtcA; nitrogen regulation; energy regulation; Protein-fragment complementation assays; PCAs; complementation reporter; environmental factors; 2-oxoglutarate

Online: 26 March 2024 (08:07:45 CET)

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Preprint REVIEW | doi:10.20944/preprints202406.0540.v1

Whey as an Optimal Substrate for the Development of Functional Products Enriched with Bioactive Peptides

Margarita Saubenova, Yelena Oleinikova, Alexander Rapoport, Sviatoslav Maksimovich, Zhanerke Yermekbay, Elana Khamedova

Subject: Biology And Life Sciences, Food Science And Technology Keywords: functional products; peptides, whey; fermentation; lactic acid bacteria; proteolytic activity.

Online: 10 June 2024 (08:49:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0477.v1

Epidemiological Changes in Orofacial Trauma between the Pre-Covid and COVID Periods: A Spanish Multicentre Comparative Study of Tertiary Referral Hospitals

Angela Sada-Urmeneta, Jose-Ignacio Salmeron-Escobar, Carlos Navarro-Cuéllar, Eduardo Olavarria, Gregorio Sanchez-Aniceto, Sonia Herrero-Alvarez, Oscar De la Sen-Corcuera, Anna-Maria Simon-Flores, Fernando Almeida, Iñigo Aragon-Niño, Jose-Luis Del Castillo, Dafne Gascon, Marc Agea, Manuel Tousidonis

Subject: Medicine And Pharmacology, Surgery Keywords: SARS-CoV-2; COVID-19; orofacial trauma; maxillofacial trauma; epidemiology; public health

Online: 7 June 2023 (03:35:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0709.v1

2-D Modeling to Understand the Design Configuration and Flow Dynamics of Pond-in-Pond (Pip) Wastewater Treatment System for Reuse

Kushal Adhikari, Clifford Fedler, Alireza Asadi

Subject: Engineering, Automotive Engineering Keywords: wastewater reuse; irrigation; sustainability; pond-in-pond; pond configuration; 2-D modeling

Online: 27 April 2021 (12:28:38 CEST)

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Working Paper HYPOTHESIS

Could Protein Malnutrition of Rapid Onset Explain the Atypical Symptoms of COVID-19 and Consequential Malfunctioning of the Body? A Hypothesis.

Maralyn Green

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: malnutrition; COVID-19; protein; immune system; SARS-CoV-2; cell proliferation; starvation

Online: 22 September 2020 (08:32:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0572.v1

Anti-diabetic Effects of Wild Soybean Glycine Soja Seed Extract on Type 2 Diabetic Mice and Human Hepatocytes induced Insulin Resistance

Eunjung Son, Hye Jin Choi, Seung-Hyung Kim, Dong-Gyu Jang, Jimin Cha, Jeong June Choi, Mee Ree Kim, Dong-Seon Kim

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: glycine soja seed; type 2 diabetes mellitus; antidiabetic; AMPK; Akt; PPAR-γ

Online: 26 August 2020 (09:16:38 CEST)

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Working Paper ARTICLE

Anti-Diabetic Effects of Wild Soybean Glycine Soja Seed Extract on Type 2 Diabetic Mice and Human Hepatocytes Induced Insulin Resistance

Eunjung Son, Hye Jin Choi, Seung-Hyung Kim, Dong-Gyu Jang, Jimin Cha, Jeong June Choi, Mee Ree Kim, Dong-Seon Kim

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Glycine soja seed; Type 2 diabetes mellitus; Antidiabetic; AMPK; Akt; PPAR-γ

Online: 25 August 2020 (11:47:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0102.v3

Potential of Plant Bioactive Compounds as SARS-CoV-2 Main Protease (M^pro) and Spike (S) Glycoprotein Inhibitors: A Molecular Docking Study

Trina Ekawati Tallei, Sefren Geiner Tumilaar, Nurdjannah Jane Niode, Fatimawali Fatimawali, Billy Johnson Kepel, Rinaldi Idroes, Yunus Effendi

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Medicinal plants; Mpro; 3CLpro; spike (S) glycoprotein; COVID-19; SARS-CoV-2

Online: 1 July 2020 (08:37:49 CEST)

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Since the outbreak of the COVID-19 (Coronavirus Disease 19) pandemic, researchers have been trying to investigate several active compounds found in plants that have the potential to inhibit the proliferation of SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2). The present study aimed to evaluate bioactive compounds found in plants by using a molecular docking approach to inhibit the Main Protease (M^pro) and Spike (S) glycoprotein of SARS-CoV-2. The evaluation was performed on the docking scores calculated using AutoDock Vina as a docking engine. A rule of five (RO5) was calculated to determine whether a compound meets the criteria as an active drug orally in humans. The determination of the docking score was done by selecting the best conformation of the protein-ligand complex that had the highest affinity (most negative Gibbs' free energy of binding / ΔG). As a comparison, nelfinavir (an antiretroviral drug), chloroquine and hydroxychloroquine sulfate (anti-malarial drugs recommended by the FDA as emergency drugs) were used. The results showed that hesperidin, nabiximols, pectolinarin, epigallocatechin gallate, and rhoifolin had better poses than nelfinavir, chloroquine, and hydroxychloroquine sulfate as spike glycoprotein inhibitors. Hesperidin, rhoifolin, pectolinarin, and nabiximols had about the same pose as nelfinavir, but were better than chloroquine and hydroxychloroquine sulfate as M^pro inhibitors. These plant compounds have the potential to be developed as specific therapeutic agents against COVID-19. Several natural compounds of plants evaluated in this study showed better binding free energy compared to nelfinavir, chloroquine, and hydroxychloroquine sulfate which so far are recommended in the treatment of COVID-19. As judged by the RO5 and previous study by others, the compounds kaempferol, herbacetin, eugenol, and 6-shogaol have good oral bioavailability, so they are also seen as promising candidates for the development lead compounds to treat infections caused by SARS-CoV-2.

Preprint ARTICLE | doi:10.20944/preprints202002.0139.v1

Restricticin B from the Marine Fungus Penicillium janthinellum and Its Inhibitory Activity on the NO Production in BV-2 Microglia Cells

Byeonung-Kyu Choi, Shin-Young Park, Song-Hee Jo, Dong-Kug Choi, Phan Thi Hoai Trinh, Hwa-Sun Lee, Van Anh Cao, Thi Duy Ngoc Ngo, Tran Thi Thanh Van, Hee Jae Shin

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: restricticin; marine fungus; Penicillium janthinellum; BV-2 microglia cells; anti-inflammatory; rotamer

Online: 11 February 2020 (09:28:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.0961.v1

Research on Short‐Term Forecasting Model of Global Atmospheric Temperature and Wind in the Near Space Based on Deep Learning

Xingxin Sun, Ting Lan, Yi Liu, Chen Zhou, Jian Feng, Huiyun Yang, Yuqiang Zhang, Zhou Chen, Tong Xu, Zhong-Xin Deng, Zhengyu Zhao

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Global atmospheric temperature and wind in the near space; ConvGRU; ConvLSTM; MERRA‐2 reanalysis dataset

Online: 13 August 2024 (14:41:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0124.v1

Early Lesion of Post-Primary Tuberculosis: Subclinical Driver of Disease and Target for Vaccines and Host-directed Therapies.

Robert E. E. Brown, Robert L Hunter

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: tuberculosis; secretory antigens; bronchiolar epithelium; alveolar pneumocytes; M2 polarization; COX-2, FAS; Pathogenesis; early lesion

Online: 5 November 2021 (14:50:58 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202005.0084.v1

Nsp7 and Spike Glycoprotein of SARS-CoV-2 Are Envisaged as Potential Targets of Vitamin D and Ivermectin

Jhimli Dasgupta, Udayaditya Sen, Abhisek Bakshi, Abhijit Dasgupta, Krishnendu Manna, Chinmay Saha, Rajat K. De, Satinath Mukhopadhyay, Nitai P. Bhattacharyya

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; Vitamin D; Ivermectin; RNA-dependent-RNA polymerase; Spike glycoprotein; Knowledge based docking

Online: 5 May 2020 (15:18:30 CEST)

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COVID-19 has emerged as deadly pandemic worldwide with no vaccine or suitable antiviral drugs to prevent or cure the disease. Because of the time-consuming process to develop new vaccines or antiviral agents, there has been a growing interest in repurposing some existing drugs to combat SARS-CoV-2. Vitamin D is known to be protective against acute respiratory distress syndrome (ARDS), pneumonia and cytokine storm. Recently it has been used as a repurposed drug for the treatment of H5N1 virus-induced lung injury. Circumstantial evidences indicate that people with low level of vitamin D are more susceptible to SARS-CoV-2. Although, vitamin D was suggested to interfere with viral replication, its interaction with any SARS-CoV-2 protein is unexplored yet. Beside this, ivermectin, a well-known anti-parasitic agent, exhibits potent anti-viral activities in vitro against viruses such as HIV-1 and dengue. Very recently, ivermectin has been found to reduce viral load of SARS-CoV-2 in vitro. We have analyzed available structures of SARS-CoV-2 proteins to identify probable binding partner(s) of vitamin D and ivermectin through knowledge-based docking studies and figured out possible implication of their binding in SARS-CoV-2 infection. Our observations suggest that the non-structural protein nsp7 possesses a potential site to house 25-hydroxyvitamin D3 (VDY) or the active form of Vitamin D, calcitrol. Binding of vitamin D with nsp7 likely to hamper the formation of nsp7-nsp8 complex which is required to bind with RNA dependent RNA polymerase (RdRP), nsp12 for optimal function. On the other hand, potential binding site of ivermectin has been identified in the S2 subunit of trimeric spike(S) glycoprotein of SARS-CoV-2. We propose that deeply inserted mode of ivermectin binding at three inter-subunit junctions may restrict large scale conformational changes of S2 helices which is necessary for efficient fusion of viral and host membrane. Our study, therefore, opens up avenues for further investigations to consider vitamin D and ivermectin as potential drugs against SARS-CoV-2.

Preprint REVIEW | doi:10.20944/preprints202302.0485.v1

Eating Disorders and Dietary Supplements: A Review of the Science

Susan J Hewlings PhD, RD

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: eating disorders 1; dietary supplements 2; disordered eating 3; eating disorder risk factors 4

Online: 28 February 2023 (02:16:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.1074.v1

Validation of Ground Based Solar Irradiance Measurements against Meteosat-Msg and Himawari-8 Satellite Data

Jitendra Kumar Meher, Syed Haider Abbas Rizvi, Bhramar Choudhary, Ravi Choudhary, Yash Thakre, Ritesh Kumar, Vikram Singh

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: BSRN; Heliosat-2; Himawari-8; Meteosat-MSG; Renewable energy; Solar Radiation; Validation Study

Online: 16 May 2024 (11:55:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.2249.v1

Assessment and Therapeutic Modulation of Heart Rate Variability: Potential Implications in Patients with COVID-19

Luiz G. Schnekenberg, Annahita Sedghi, Daniela Schöne, Lars-Peder Pallesen, Jessica Barlinn, Felix Woitek, Axel Linke, Volker Puetz, Kristian Barlinn, Norman Mangner, Timo Siepmann

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: SARS-CoV-2; COVID-19; heart rate variability; cardiac; cardiovascular; parasympathetic; sympathetic; autonomic

Online: 31 May 2023 (12:55:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0075.v1

A New Way to 2,3,4-Trisubstituted Benzo[h]quinolines: Synthesis, Consecutive Reactions and Cellular Activities

Viktor A. Zapol’skii, Sandra Kaul, Bianka Karge, Mark Brönstrup, Mimoza Gjikaj, Dieter E. Kaufmann

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: synthetic methods; 2-nitroperchlorobutadiene; benzoquinolines; cyclization; amines; sulfides; nucleophilic substitution; oxidation; medicinal chemistry

Online: 3 February 2023 (13:49:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0454.v1

The Silver Bullet: A Safe and Efficient Attenuated Vaccine for Viral Diseases Based on Biothermodynamics

Marko Popovic

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; SARS-CoV-2; Vaccine; Attenuation; Biothermodynamics; Gibbs energy; Permissiveness; Biosynthesis; Multiplication

Online: 23 December 2022 (08:15:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202106.0237.v1

Confounding Factors Influencing the Kinetic and the Magnitude of Serological Response Following Administration of BNT162b2

Jean-Louis Bayart, Laure Morimont, Mélanie Closset, Grégoire Wieërs, Tatiana Roy, Vincent Gerin, Marc Elsen, Christelle Eucher, Sandrine Van Eeckhoudt, Nathalie Ausselet, Clara David, François Mullier, Jean-Michel Dogné, Julien Favresse, Jonathan Douxfils

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: SARS-CoV-2; vaccine; BNT162b2; antibody, serology; kinetic; age; gender; BMI; blood-group.

Online: 8 June 2021 (13:48:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1352.v1

Personalized Assessment of Mortality Risk and Hospital Stay Duration in Hospitalized Patients with COVID-19 Treated with Remdesivir: A Machine Learning Approach

Antonio Ramón, Andrés Bas Castillo, Santiago Herrero González, Pilar Blasco, Miguel Suárez, Jorge Mateo

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: COVID-19; hospital stay; machine learning; mortality; SARS-CoV-2; remdesivir; XGB

Online: 24 February 2024 (08:57:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints201707.0033.v1

Combination of Hypertension and High Fat and Cholesterol Diet Induces Severe Hepatic Inflammation in Rats via a Signaling Network Comprising NF-κB, MAPK, and Nrf2 Pathways

Yuan Yuan, Hisao Naito, Kazuya Kitamori, Tamie Nakajima

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: hepatic inflammation; high-fat-cholesterol diet; hypertension; mitogen-activated protein kinase; nonalcoholic steatohepatitis; nuclear factor erythroid 2-related factor 2 pathway; nuclear factor-kappa B; spontaneously hypertensive rat; stroke-prone spontaneously hypertensive5/Dmcr; Wistar Kyoto

Online: 14 July 2017 (10:54:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0749.v1

Ajwa Date Seed Mediated Green Synthesis of Alginate-Silver Nanocomposite Beads and Films for Antibacterial and Catalytic Degradation Applications

Naba Almukharraq, Marwa Almarzooqi, Hasan Ruyan, Fatima AlHannan, Praveen Kumar, Fryad Henari, G. Roshan Deen

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: Ajwa dates seed; silver nanoparticles; green synthesis; alginate beads; degradation;
2-nitrophenol, antibacterial activities

Online: 12 June 2024 (00:10:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1049.v1

How Aging Affects Insulin Resistance, Insulin Secretion, and Glucose Effectiveness in Subjects with Normal Blood Glucose and Body Weight

Li-Ying Huang, Chi-Hao Liu, Fang-Yu Chen, Chun-Heng Kuo, Pietro Pitrone, Jhih-Syuan Liu

Subject: Biology And Life Sciences, Aging Keywords: first-phase insulin secretion; second-phase insulin secretion; insulin resistance; glucose effectiveness; type 2 diabetes

Online: 27 April 2023 (05:23:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0262.v1

Isolation and Characterization of Erianthus arundinaceus Phosphate Transporter 1 (PHT1) Gene Promoter and 5′ Deletion Analysis of Transcriptional Regulation Regions under Phosphate Stress in Transgenic Tobacco

Murugan Naveenarani, HK Mahadevswamy, Sakthivel Surya Krishna, Channappa Mahadevaiah, Ramanathan Valarmathi, Markandan Manickavasagam, Muthukrishnan Arun, Govindakurup Hemaprabha, Chinnaswamy Appunu

Subject: Environmental And Earth Sciences, Soil Science Keywords: Erianthus arundinaceus; High-affinity phosphate transporter; PHT1; 2; Promoter analysis; Tobacco transgenic; Pi stress

Online: 5 October 2023 (12:04:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202311.1218.v1

Immunosenescence and Cytomegalovirus: Exploring Their Connection in the Context of Aging, Health, and Disease

Ludmila Müller, Svetlana Di Benedetto

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: aging; immunosenescence; cytomegalovirus; inflammaging; CMV latency; COVID-19; SARS-CoV-2; long COVID; age-related diseases

Online: 20 November 2023 (05:14:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202303.0009.v1

Integrating AI/ML Models for Patient Stratification Leveraging Omics Dataset and Clinical Biomarkers from COVID-19 Patients: A Promising Approach to Personalized Medicine

Babatunde Bello, Yogesh Naren Bundey, Roshan Bhave, Maksim Khotimchenko, Szczepan W. Baran, Kaushik Chakravarty, Jyotika Varshney

Subject: Medicine And Pharmacology, Other Keywords: SARS-CoV-2; COVID-19; artificial intelligence; omics; patient stratification; risk management

Online: 1 March 2023 (03:37:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202206.0255.v1

Short Linear Motifs in the Spike Protein of Sars-Cov-2 Variants Provide Clues Into Immune Hijack and Evasion Mechanisms of Omicron Variant

Anjana Soorajkumar, Ebrahim Alakraf, Mohammed Uddin, Stefan S Du Plessis, Alawi Alsheikh-Ali, Richard K. Kandasamy

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: coronaviruses; SARS-CoV-2; variant; Omicron; SLiMs; spike protein; motifs; covid-19

Online: 17 June 2022 (13:49:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0069.v1

Variability in the Control of Type 2 Diabetes in Primary Care and Its Association with Hospital Admissions for Vascular Events. The APNA Study.

Sara Guillen-Aguinaga, Luis Forga, Antonio Brugos-Larumbe, Francisco Guillen-Grima, Laura Guillen-Aguinaga, Ines Aguinaga-Ontoso

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Healthcare Disparities; Diabetes Mellitus, Type 2; Vascular Diseases; Primary Health Care; Cohort

Online: 3 September 2021 (14:58:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0548.v1

Transfer Learning for the Detection and Diagnosis of Types of Pneumonia Including Pneumonia Induced by the COVID-19 from Chest X-Ray Images

Yusuf Brima, Marcellin Atemkeng, Stive Tankio Djiokap, Jaures Ebiele, Franklin Tchakounté

Subject: Engineering, Automotive Engineering Keywords: ANN; COVID-19; CT; mRNA; MRI; RT-PCR; SARS-CoV-2; XCR

Online: 23 July 2021 (15:02:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0285.v1

Clinical, Laboratory, and Radiological Features Indicative of Novel Coronavirus Disease (COVID-19) in Emergency Departments – A Multicentre Case-Control Study in Hong Kong

Rex Pui Kin Lam, Kevin Kei Ching Hung, Eric Ho Yin Lau, Chun Tat Lui, Kin Ling Chan, Chin San Leung, Ion Wa Wong, Kin Wa Wong, Colin A. Graham, Patrick Chiu Yat Woo

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; SARS-CoV-2; emergency department; early diagnosis; case-control studies

Online: 17 May 2020 (08:27:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202211.0430.v1

Attenuation and Degeneration of SARS-CoV-2 Despite of Adaptive Evolution

Yingguang Liu

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2, evolution, immune evasion, codon usage, attenuation, genome degradation, degeneration, COVID-19

Online: 23 November 2022 (03:29:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0578.v1

A Note on Type 2 Degenerate Poly-Fubini Polynomials and Numbers

Waseem Khan

Subject: Computer Science And Mathematics, Mathematics Keywords: Modified degenerate polexponential function; Fubini polynomials; type 2 degenerate poly-Fubini polynomials; unipoly functions

Online: 24 September 2020 (10:52:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1023.v1

A Contribution to the Integration of International, National and Local Cultural Heritage Protection through a Multilevel Approach to Planning: A Case Study of the Djerdap Area

Ana Niković, Božidar Manić, Nataša Čolić Marković, Nikola Krunić

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Djerdap; Danube; spatial plan; protected area; cultural heritage; multilevel approach

Online: 16 April 2024 (10:27:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.2087.v1

SARS-CoV-2 and Influenza Vaccine Hesitancy during the COVID-19 Pandemic in a Dynamic Perspective

Valentina Gerussi, Maddalena Peghin, Alvisa Palese, Maria De Martino, Elena Graziano, Stefania Chiappinotto, Federico Fonda, Giulia Bontempo, Tosca Semenzin, Luca Martini, Miriam Isola, Carlo Tascini

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Influenza; COVID-19; SARS-CoV-2; Green-Pass; Vaccination; Immunization; Vaccine-hesitancy; Pandemic

Online: 29 June 2023 (10:23:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0565.v1

Physiological and Transcriptomic Analysis Provides Insights into Low Nitrogen Stress in Foxtail Millet (Setaria italica L.).

Erying Chen, Ling Qin, Feifei Li, Yanbing Yang, Zhenyu Liu, Xiao Yu, Jiahong Niu, Runfeng Wang, Huawen Zhang, Hailian Wang, Bin Liu, Yanan Guan

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: foxtail millet 1; nitrogen use efficiency 2; varieties3; physiological parameters 4; transcriptomics 5.

Online: 9 May 2023 (04:41:12 CEST)

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Foxtail millet (Setaria italica (L.) P. Beauv) is an important food and forage crop that is well adapted to nutrient-poor soils. However, little is known about how foxtail millet adapts to low nitrogen (LN) at the physiological and molecular levels. In the present study, two foxtail millet varieties with contrasting low nitrogen (LN) tolerance properties were investigated through integrative analyses of physiological featureparameters and transcriptomics. The physiological results showed that JG20 (high tolerance to LN) had higher biomass accumulation, nitrogen content and nitrogen use efficiency compared with JG22 (low tolerancesensitive to LN) under LN. JG20 had higher soluble sugar and soluble protein concentration in shoots compared with JG22 under LN, while contcentrations of soluble sugar and soluble protein contents were higher in the roots of JG22. Higher levels of CTK contentzeatin concentration were found in the shoots of JG20 com-pared with JG22, and a higher ABA contcentration was found in both the shoots and roots of JG22 compared with JG20 under LN. In the transcriptomics results, JG20 had more differentially ex-pressed genes (DEGs) than JG22 both in shoots and roots in response to LN. These LN-responsive genes were enriched in glycolysis, starch and sucrose metabolism, photosynthesis, biosynthesis of amino acids, hormone metabolism and nitrogen metabolism. Furthermore, the high-affinity nitrate transporter gene, SiNRT2.1, and glutamine synthetase gene, SiGS5, chlorophyll apoprotein of photosystem II gene, SiPsbQ, ATP synthase subunit gene, b, auxin-responsive protein gene, SiIAA25, and aldose 1-epimerase gene, SiAEP, in shoots, and high-affinity nitrate transporter gene, SiNRT2.3, SiNRT2.4, and glutamate synthase gene, SiGOGAT2, auxin-responsive protein gene, SiIAA4, fructose-bisphosphate aldolase gene, SiAEP5, in root, were important genes in-volved in the LN tolerance of foxtail millet. These results provide a detailed description of the physiological and transcriptome response of foxtail millet under LN condition.

Preprint ARTICLE | doi:10.20944/preprints202209.0084.v2

The CSHQ-DE Questionnaire Uncovers Relevant Sleep Disorders in Children and Adolescents with Long COVID-19

Sarah Werner, Claus Doerfel, Richard Biedermann, Michael Lorenz, Marius Rasche, Hans Proquitté, Lars Newman, Daniel Vilser

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: long COVID; Post COVID-19 condition; sleep disorders, SARS-CoV-2; Coronavirus; children

Online: 14 October 2022 (10:13:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202204.0009.v1

How Smell Regulates Metabolism: The Role Of Ectopically Expressed Olfactory Receptors In Lipid and Glucose Homeostasis

Ginevra Urbani, Eleonora Distrutti, Michele Biagioli, Silvia Marchianò, Stefano Fiorucci

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: olfactory receptors; glucose metabolism; type 2 diabetes mellitus; lipid metabolism; NAFLD; metabolic syndrome

Online: 2 April 2022 (09:00:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0481.v1

Minimizing Errors in RT-PCR Detection and Quantification of SARS-CoV-2 RNA for Wastewater Surveillance

Warish Ahmed, Stuart Simpson, Paul Bertsch, Kyle Bibby, Aaron Bivins, Linda Blackall, Silvia Bofill-Mas, Albert Bosch, Joao Brandao, Phil Choi, Mark Ciesielski, Erica Donner, Nishita D'Souza, Andreas Farnleitner, Daniel Gerrity, Raul Gonzalez, John Griffith, Pradip Gyawali, Charles Haas, Kerry Hamilton, Chanditha Hapuarachchi, Valerie Harwood, Rehnuma Haque, Greg Jackson, Stuart Khan, Wesaal Khan, Masaaki Kitajima, Asja Korajkic, Giuseppina La Rosa, Blythe Layton, Erin Lipp, Sandra McLellan, Brian McMinn, Gertjan Medema, Suzanne Metcalfe, Wim Meijer, Jochen Mueller, Heather Murphy, Colleen Naughton, Rachel Noble, Sudhi Payyappat, Susan Petterson, Tarja Pitkanen, Veronica Rajal, Brandon Reyneke, Fernando Roman, Joan Rose, Marta Rusinol, Michael Sadowsky, Laura Sala-Comorera, Yin Xiang Setoh, Samendra Sherchan, Kwanrawee Sirikanchana, Wendy Smith, Joshua Steele, Rosalie Sabburg, Erin Symonds, Phong Thai, Kevin Thomas, Josh Tynan, Simon Toze, Janelle Thompson, Andy Whiteley, Judith Wong, Daisuke Sano, Stefan Wuertz, Irene Xagoraraki, Qian Zhang, Amity Zimmer-Faust, Orin Shanks

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: COVID-19; SARS-CoV-2; Wastewater; Surveillance; False-positive; False-negative; RT-PCR

Online: 19 April 2021 (13:08:13 CEST)

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Wastewater surveillance for pathogens using the reverse transcription-polymerase chain reaction (RT-PCR) is an effective, resource-efficient tool for gathering additional community-level public health information, including the incidence and/or prevalence and trends of coronavirus disease-19 (COVID-19). Surveillance of SARS-CoV-2 in wastewater may provide an early-warning signal of COVID-19 infections in a community. The capacity of the world’s environmental microbiology and virology laboratories for SARS-CoV-2 RNA characterization in wastewater is rapidly increasing. However, there are no standardized protocols nor harmonized quality assurance and quality control (QA/QC) procedures for SARS-CoV-2 wastewater surveillance. This paper is a technical review of factors that can lead to false-positive and -negative errors in the surveillance of SARS-CoV-2, culminating in recommendations and strategies that can be implemented to identify and mitigate these errors. Recommendations include, stringent QA/QC measures, representative sampling approaches, effective virus concentration and efficient RNA extraction, amplification inhibition assessment, inclusion of sample processing controls, and considerations for RT-PCR assay selection and data interpretation. Clear data interpretation guidelines (e.g., determination of positive and negative samples) are critical, particularly during a low incidence of SARS-CoV-2 in wastewater. Corrective and confirmatory actions must be in place for inconclusive and/or potentially significant results (e.g., initial onset or reemergence of COVID-19 in a community). It will also be prudent to perform inter-laboratory comparisons to ensure results are reliable and interpretable for ongoing and retrospective analyses. The strategies that are recommended in this review aim to improve SARS-CoV-2 characterization for wastewater surveillance applications. A silver lining of the COVID-19 pandemic is that the efficacy of wastewater surveillance was demonstrated during this global crisis. In the future, wastewater will play an important role in the surveillance of a range of other communicable diseases.

Preprint ARTICLE | doi:10.20944/preprints202002.0308.v1

Pharmacoinformatics and Molecular Dynamic Simulation Studies Reveal Potential Inhibitors of SARS-CoV-2 Main Protease 3CL^pro

Mubarak A. Alamri, Muhammad Tahir ul Qamar, Safar M. Alqahtani

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: SARS-CoV-2; COVID-19; 3CL protease; molecular docking; molecular dynamics and simulations

Online: 23 February 2020 (02:17:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.1356.v1

Impact of Southerly Surge on Rainfall Pattern Over Java, Bali, West Nusa Tenggara and East Nusa Tenggara during Asian Winter Monsoon and Its Relationship to MJO Condition

Trismidianto Trismidianto, Didi Satiadi, Wendi Harjupa, Ibnu Fathrio, Risyanto Risyanto, Elfira Saufina, Robi Muharsyah, Danang Eko Nuryanto, Fadli Nauval, Dita Fatria Andarini, Anis Purwaningsih, Teguh Harjana, Alfan Sukmana Praja, Adi Witono, Ina Juaeni, Bambang Suhandi

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Southerly Surge; MJO; Rainfall; Java Island; East Nusa Tenggara

Online: 19 June 2024 (14:10:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0168.v2

Effect of the Light Environment on Image-Based SPAD Value Prediction of Radish Leaves

Yuto Kamiwaki, Shinji Fukuda

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Lighting conditions; Leaf colors; Random Forests; Raphanus sativus L. var. sativus; RGB; SPAD value; Machine learning; Image processing; Color image processing

Online: 6 November 2023 (01:22:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1307.v1

Efficacy Study of a Dietary Supplement Containing Collagen‐L‐Arginine‐Hyaluronic Acid in Elderly Patients with Musculoskeletal Complaints

Péter Fritz, Lívia Mayer, Pál Bóday, Annamária Maszlag, Réka Fritz

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: diatary supplement; body composition; laboratory results; collagen and hyaluron acid oral supplementation; articular movement improvement; C vitamin; L-arginin; health promotion

Online: 19 June 2023 (07:19:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0625.v1

Investigating Producer Preferences for Crapemyrtle (Lagerstroemia indica L.: Lythraceae) & Their Perceptions Regarding Crapemyrtle Bark Scale

Pulkit Marwah, Yu Yvette Zhang, Mengmeng Gu

Subject: Biology And Life Sciences, Horticulture Keywords: Crapemyrtle (Lagerstroemia indica L.: Lythraceae); Crapemyrtle Bark Scale (Acanthococcus lager-stroemiae (Kuwana, 1907)); flowering tree; pest; producer survey; relative importance index

Online: 23 April 2021 (09:55:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1950.v1

A Lightweight and High-Precision Passion Fruit YOLO Detection Model for Deployment in Embedded Devices

Qiyan Sun, Pengbo Li, Chentao He, QiMing Song, Zhicong Luo

Subject: Engineering, Electrical And Electronic Engineering Keywords: passion fruit detection; lightweight; deep learning; knowledge distillation; embedded devices

Online: 29 May 2024 (14:12:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1504.v2

Dual Release of Daptomycin and BMP-2 from a Composite of β-TCP Ceramic and ADA Gelatin for Bone Regeneration

Lucas Ritschl, Pia Schilling, Annette Wittmer, Annerose Serr, Hagen Schmal, Michael Seidenstuecker

Subject: Biology And Life Sciences, Life Sciences Keywords: dual release, daptomycin, BMP-2, β-TCP scaffold, ADA-gelatin gel, bone infection, bone regeneration

Online: 24 November 2023 (08:41:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0075.v2

Structural, Magnetic and Mossbauer studies of Transition metal doped Gd2Fe16Ga0.5TM0.5 intermetallic compounds (TM=Cr, Mn, Co, Ni, Cu, and Zn)

Jiba Dahal, Syed Ali Kalangala Sikkanther Batcha, Jahangir Alam

Subject: Chemistry And Materials Science, Electronic, Optical And Magnetic Materials Keywords: Permanent magnetic materials, 2:17 intermetallics, Mossbauer Spectroscopy, Curie temperature, X-ray diffraction, Rietveld analysis

Online: 5 October 2018 (11:59:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1484.v1

Assessment of SLAM Scanner Accuracy for Outdoor and Indoor Surveying Tasks

Zahra Gharineiat, Fayez Tarsha Kurdi, Krish Henny, Hamish Gray, Aaron Jamieson, Nicholas Reeves

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: SLAM; LiDAR; accuracy assessment; indoor and outdoor; data acquisition

Online: 23 April 2024 (11:59:07 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0041.v1

A Significance of an Amelioration of Endothelial Dysfunction by Sodium-Glucose Cotransporter 2 Inhibitors for an Improvement of Heart Failure and Chronic Kidney Disease

Hidekatsu Yanai, Hiroki Adachi, Mariko Hakoshima, Hisayuki Katsuyama

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: endothelial dysfunction; chronic kidney disease; heart failure; sodium-glucose cotransporter 2 inhibitors

Online: 2 May 2023 (02:18:51 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202311.1400.v1

Preclinical and Clinical Observations Implying Combination Therapy to Enhance the Efficacy of the Her-2/Neu B Cell Peptide-Based Vaccine Her-Vaxx and to Prevent Immune Evasion

Joshua Tobias, Sandra Högler, Martin Raigel, Diego Shih-Chieh Lin, Yee Chao, Lukas Kenner, Erika Garner-Spitzer, Sharon Yavrom, Nicholas J. Ede, Christoph C. Zielinski, Michael Kundi, Ursula Wiedermann

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: PD-L1; Her-2/neu; Expression; Preclinical and clinical settings; Immune evasion; Combination therapy

Online: 22 November 2023 (07:30:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0588.v1

Honors and Costs of Being Heroes: Risk Factors and Epidemiology of COVID-19 Infection among Health Care Workers of a Severely Hit COVID-19-Referral Hospital in Italy

Marta Colaneri, Viola Novelli, Sara Cutti, Alba Muzzi, Guido Resani, Cristina Monti, Claudia Rona, Anna Maria Grugnetti, Marco Rettani, Francesca Rovida, Valentina Zuccaro, Antonio Triarico, Carlo Marena

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: retrospective cohort study; COVID-19; SARS-CoV-2; health care workers; risk of infection

Online: 27 August 2020 (03:25:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.0932.v1

Targeting the Metabolic Paradigms in Cancer and Diabetes

Mira Bosso, Dania Haddad, Ashraf Al Madhoun, Fahd Al-Mulla

Subject: Biology And Life Sciences, Life Sciences Keywords: oxidative phosphorylation; cancer; mitochondria; metabolic shift; type 2 diabetes; insulin resistance; therapy; nutritional adjuvants; glutaminolysis

Online: 13 December 2023 (03:26:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.0696.v1

Is the β₃-Adrenoceptor a Valid Target for the Treatment of Obesity and/or Type 2 Diabetes?

Haneen S. Dwaib, Martin C. Michel

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: β3-adrenoceptor; obesity; type 2 diabetes; species difference; insulin release; glucose uptake; thermogenesis

Online: 11 October 2023 (14:22:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1362.v1

The Rise and Fall of Omicron BA.1 Variant as Seen in Wastewater Supports Epidemiological Model Predictions

Michal Liddor Naim, Yu Fu, Marilou Shagan, Itay Bar-Or, Robert Marks, Qun Sun, Rony Granek, Ariel Kushmaro

Subject: Public Health And Healthcare, Health Policy And Services Keywords: SARS-CoV-2; Omicron; Wastewater-based epidemiology; RT-qPCR; SIR model; SIRS model

Online: 20 July 2023 (11:44:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0334.v1

Molecular Docking and Molecular Dynamic Study of Two Viral Proteins Associated with SARS-CoV-2 with Ivermectin

Lenin Andres Gonzalez Paz, Carla A. Lossada, Luis S. Moncayo, Freddy Romero, J. L. Paz, Joan Vera-Villalobos, Aleivi E. Perez, Ernesto San-Blas, Ysaias J. Alvarado

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: SARS-COV-2; folding/unfolding; antiparasitic; molecular docking; molecular dynamics; COVID-19; Ivermectin

Online: 19 April 2020 (06:56:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0195.v1

Divergent Effects of Glycemic Control and Bariatric Surgery on Circulating Concentrations of TMAO in Newly Diagnosed T2D Patients and Morbidly Obese

Marina Canyelles, Antonio Pérez, Alexandra Junza, Inka Miñambres, Oscar Yanes, Helena Sardà, Noemí Rotllan, Josep Julve, Sònia Benitez, José Luis Sánchez-Quesada, Mireia Tondo, Joan Carles Escolà-Gil, Francisco Blanco-Vaca

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: γ-butyrobetaine; glycemic control; liquid chromatography–mass spectrometry; obesity; trimethylamine N-oxide; type 2 diabetes

Online: 14 September 2022 (08:08:33 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202404.1727.v1

Persistently High Platelet Factor 4 Levels in an Adolescent With Recurrent Late Thrombotic Complications After SARS-CoV-2 mRNA Vaccination

Yoichi Haga, Akira Ohara, Tsuneyoshi Yakuwa, Akari Yamashita, Midori Udo, Masaki Matsuoka, Hiroshi Ohara, Atsushi Yasumoto, Hiroyuki Takahashi

Subject: Medicine And Pharmacology, Hematology Keywords: ; platelet factor 4; SARS-CoV-2 vaccine; venous thrombosis; antiphospholipid syndrome; anticoagulants ;

Online: 28 April 2024 (07:30:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0516.v1

SGLT -2 Inhibitors and the Inflammasome: What's next in the 21st century?

Dimitris Kounatidis, Natalia Vallianou, Angelos Evangelopoulos, Ioannis Vlachodimitris, Eugenia Grivakou, Evangelia Kotsi, Krystalia Dimitriou, Alexandros Skourtis, Iordanis Mourouzis

Subject: Medicine And Pharmacology, Internal Medicine Keywords: SGLT-2 Inhibitors; Inflammasome; NLRP3; reno-protective effects; Cardio-protective effects; neuro-protective effects.

Online: 18 April 2023 (10:33:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202010.0407.v2

Vitamin C—An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19

Patrick Holford, Anitra Carr, Thomas H. Jovic, Stephen R. Ali, Iain S. Whitaker, Paul Marik, David Smith

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; SARS-CoV-2; coronavirus; vitamin C; ascorbate; colds; pneumonia; sepsis; immunonutrition; supplementation

Online: 30 November 2020 (15:23:16 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202409.2124.v1

SARS-CoV-2 Displays a Suboptimal Codon Usage Bias for Efficient Translation in Human Cells Diverted by Hijacking the tRNA Epitranscriptome

Patrick ELDIN, Alexandre DAVID, Christophe HIRTZ, Jean-Luc BATTINI, Laurence BRIANT

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; codon usage; tRNA; epitranscriptome; translation

Online: 27 September 2024 (03:21:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1834.v1

Novel Metabolites Associated with Decreased Gfr: A 12-Year Follow-Up of the METSIM Cohort

Lilian Fernandes Silva, Jagadish Vangipurapu, Anniina Oravilahti, Markku Laakso

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Genetics; metabolomics; type 2 diabetes; glomerular filtration rate

Online: 26 August 2024 (11:26:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1743.v1

A Multi-target Pharmacological Correction of a Lipoyltransferase LIPT1 Gene Mutation in Patient-Derived Cellular Models

David Gómez-Fernández, Ana Romero-González, Juan M. Suárez-Rivero, Paula Cilleros-Holgado, Mónica Álvarez-Córdoba, Rocío Piñero-Pérez, José Manuel Romero-Domínguez, Diana Reche-López, Alejandra López-Cabrera, Salvador Ibañez-Mico, Marta Castro de Oliveira, Andrés Rodríguez-Sacristán, Susana Gónzalez-Granero, José Manuel García-Verdugo, José A Sánchez-Alcázar

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: LIPT1; SIRT3; fibroblasts; lipoylation; bioenergetics; 2-ketoacid dehydrogenase

Online: 22 July 2024 (14:19:16 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202401.0503.v1

Hibernating Bats are a Weak Source for Biomonitoring of Coronaviruses

Aleksander Goll, Lara Dutra, Joanna Nowicka, Elena Sgarabotto, Vinaya Venkat, Grzegorz Apoznański, Tomasz Kokurewicz, Alek Rachwald, Lukasz Rabalski, Hussein Alburkat, Jenni Virtanen, Tarja Sironen, Ravi Kant, Vincent Bourret, Maciej Grzybek

Subject: Biology And Life Sciences, Virology Keywords: bat-borne diseases; biomonitoring; coronaviruses; SARS-CoV-2

Online: 5 January 2024 (14:50:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1078.v1

Immunogenicity of Tetravalent Protein Vaccine, SCTV01E-2 against SARS-CoV-2 EG.5 Subvaraint: a Phase 2 Trial

Jihai Tang, Qinghua Xu, Chaoyin Zhu, Kun Xuan, Tao Li, Qingru Li, Xingya Pang, Zhenqiu Zha, Jinwei Li, Liyang Qiao, Haiyang Xu, Gang Wu, Yan Tian, Jun Han, Cuige Gao, Gui Qian, Xuxin Tian, Liangzhi Xie

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Safety; Immunogenicity; SARS-CoV-2; Multivalent vaccine; Booster

Online: 15 December 2023 (01:43:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0533.v1

ERK1 Is a Regulatory Kinase Coordinating ERK2 Function in Colon Adenocarcinoma

Alessia Parascandolo, Giulio Benincasa, Francesco Corcione, Mikko O. Laukkanen

Subject: Biology And Life Sciences, Life Sciences Keywords: Colon tumorigenesis; ERK1/2; SOD3; migration, invasion; proliferation

Online: 8 December 2023 (04:56:53 CET)

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