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Preprint ARTICLE | doi:10.20944/preprints202408.0102.v1

Effect of a Phytochemical-Rich Olive Derived Extract on Anthropometric, Hematological and Metabolic Parameters

Anna Aiello, Luana Calabrone, Douglas Noonan, Paola Corradino, Sara Nofri, Simone Cristoni, Giulia Accardi, Giuseppina Candore, Calogero Caruso, Angelo Zinellu, Adriana Albini

Subject: Biology And Life Sciences, Life Sciences Keywords: extra virgin olive oil; olive mill wastewater; phytochemicals; polyphenols; antioxidants; antiaging; metabolic syndrome; cancer

Online: 4 August 2024 (16:23:54 CEST)

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Background: Extra virgin olive oil is a fundamental component of the Mediterranean diet. It contains several molecules that sustain human well-being by modulating cellular metabolism and exerting antioxidant, anti-inflammatory, anti-ageing effects to protect normal tissues and can exert anti-angiogenic, and pro-apoptotic effects on cancer cells. Metabolites found in different parts of the olive tree, including leaves, also possess properties that might help in cancer prevention and promote wellness in aging. Olive mill wastewater (OMWW), a liquid residue produced during olive oil extraction, represents an environmental issue. However, it is enriched in phytochemicals with potential beneficial properties. Dietary supplements based on OMWW can be produced for nutritional supplementation with advantages to the ecology. Purpose: This work aims to measure hematochemical, anthropometric and metabolomic parameters in volunteers assuming an OMWW dietary supplement, OliphenoliaⓇ (OMWW-OL). Methods: The supplementation of OMWW-OL 25 mL twice daily for 30 days was tested on a pilot cohort of volunteers with characteristics close to metabolic syndrome. Hematochemical, anthropometric, and metabolomic parameters were analyzed before the intervention, at 30 days and 30 days after stopping consumption. Results: 29 volunteers were enrolled and 23 completed the study. The participants’ parameters at baseline were measured, and then twice daily at 30 days of treatment and 30 days after assumption discontinuation. Although treatment was with an olive derivative, weight and body mass index instead of increasing slightly decreased, particularly in women. Also, hydration increased, especially in women, while blood pressure, glycemia and insulin decreased. Cholesterol, low-density and high-density lipoproteins and triglycerides were stable while vitamin D levels, alongside calcium, sensibly increased. Albumin also increased and parameters related to sarcopenia displayed promising, although not statistically significant, trends toward positive effects. All the values were in support of an equilibrium with no damaging effects. By mass spectrometry analysis, we also found favorable changes in the vitamin D/histamine and homocysteine/methionine ratios, an increase in a new metabolite of unknown formula, and vitamin D/unknown metabolite ratio. Conclusions: Supplementation of OMWW-OL has no detrimental effects and, although with limited potency of a pilot study, might imply the beneficial modulation of several biological parameters, being potentially valuable for people at risk of metabolic syndrome. Some of these parameters could also be relevant as anti-ageing and in cancer prevention.

Preprint REVIEW | doi:10.20944/preprints202402.0576.v1

A Scoping Review of Children, Empowerment and Smartphone Technology Regarding Social Construction Theory with the Aim of Increasing Self-Direction in Democracies

Carol Nash

Subject: Public Health And Healthcare, Health Policy And Services Keywords: children; Social Construction Theory; democracies; childhood; self-direction; empowerment; smartphones

Online: 9 February 2024 (11:18:58 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202407.1480.v1

Valley‐Spin‐Polarization of MoS2 Monolayer Induced by Ferromagnetic Order in an Antiferromagnet

Chun-Wen Chan, Chia-Yun Hsieh, Fang-Mei Chan, Pin-Jia Huang, and Chao-Yao Yang

Subject: Physical Sciences, Condensed Matter Physics Keywords: molybdenum disulfide; valleytronics; antiferromagnet; magnetic proximity effect

Online: 18 July 2024 (09:43:46 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.0186.v1

Blood-Brain Barrier Conquest in Glioblastoma Nanomedicine: Strategies, Clinical Advances, and Emerging Challenges

Mengyun Duan, Ruina Cao, Yuan Yang, Xiaoguang Chen, Lian Liu, Boxu Ren, Lingzhi Wang, Boon-Cher Goh

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Glioblastoma; Blood-brain barrier; Drug delivery; Nanomedicine delivery system; Nanoparticles

Online: 3 September 2024 (08:06:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0577.v2

New Quantum Diodes with Superconducting Properties at Non-Freezing Temperatures, and Their Computing Applications

Shinichi Ishiguri

Subject: Physical Sciences, Acoustics Keywords: quantum diode; quantum gate element; novel superconductivity; bias current; memorization property; quantum correlation

Online: 17 November 2020 (12:50:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.0512.v1

Evidence On Viral Suppression Supports Scaling-Up Transition To Dolutegravir-Based Regimens In Pediatric Populations In Cameroon: A Multicentre Baseline Assessment For The Cipher-Adola Study

Joseph FOKAM, Yagai Bouba, Rogers Awoh Ajeh, Dominik Tameza Guebiapsi, Suzane Essamba, Albert Franck Zeh Meka, Ebiama Lifanda, Rose Armelle Ada, Yakouba Liman, Nancy Barbara Mbengono, Audrey Raissa Dzaddi Djomo, Suzie Ndiang Tetang, Samuel Martin Sosso, Jocelyne Carmen Babodo, Olivia Francette Ndomo Ambomo, Edith Michele Temgoua, Caroline Medouane, Sabine Ndejo Atsinkou, Justin Leonel Mvogo, Roger Martin Onana, Jean de Dieu Anoubissi, Alice Ketchaji, Alex Durand Nka, Davy-Hyacinthe Anguechia Gouissi, Aude Christelle Ka’e, Nadine Nguendjoung Fainguem, Rachel Simo Kamgaing, Désiré Augustin Komego Takou, Michel Carlos Tommo Tchouaket, Ezechiel Ngoufack Jagni Semengue, Marie Atsama Amougou, Julius Nwobegahay, Comfort Vuchas, Anna Nya Nsimen, Bertrand Bille Eyoum, Sandra kenmegne Gatchuessi, Francis Ndongo Ateba, Daniel Kesseng, Serge Clotaire Billong, Daniele Armenia, Maria Mercedes Santoro, Francesca Ceccherini-Silberstein, Paul Ndombo Koki, Hadja Cherif Hamsatou, Vittorio Colizzi, Alexis Ndjolo, Carlo Federico Perno, Anne-Cécile Zoung-Kanyi Bissek

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Virological suppression; low level viremia; children, adolescents, and young-adults; DTG-based regimen; elimination of paediatric AIDS; Cameroon.

Online: 5 July 2024 (12:31:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0565.v1

Correlation of Albumin, Red Cell Distribution Width and Other Biochemical and Hematological Parameters with Glycated Hemoglobin in Diabetic, Prediabetic and Non-diabetic Patients

Argyrios Ginoudis, Stavroula Ioannidou, Georgia Tsakiroglou, Konstantina Kazeli, Eleni Vagdatli, Evgenia Lymperaki

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Diabetes; Glycated Hemoglobin; Mean Platelet Volume; Red Blood Cell Distribution Width; Sodium; Urea; Albumin

Online: 8 July 2024 (09:04:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0403.v1

Design of Multichannel Spectrum Intelligence Systems using Approximate DFT Algorithm for Antenna Array based Spectrum Perception Applications

Arjuna Madanayake, Keththura Lawrance, Bopage Umesha Kumarasiri, Sivakumar Sivasankar, Thushara Gunaratne, Chamira U. S. Edussooriya, Renato J. Cintra

Subject: Engineering, Telecommunications Keywords: approximate discrete Fourier transform; wideband spectrum perception; wideband multi-beam RF digital beamforming; low-complexity algorithms

Online: 4 July 2024 (11:12:46 CEST)

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The radio spectrum is a scarce and extremely valuable resource that demands careful real-time monitoring and dynamic resource allocation. Dynamic spectrum access (DSA) is a new paradigm for managing the radio spectrum, which requires AI/ML driven algorithms for optimum performance under rapidly changing channel conditions and possible cyber-attacks in the electromagnetic domain. Fast sensing across multiple directions using array processors, with subsequent AI/ML based algorithms for sensing and perception of the waveforms that are measured from the environment is critical for providing decision support in DSA. As part of directional and wideband spectrum perception, the ability to finely channelize wideband inputs using efficient Fourier analysis is much needed. However, a fine-grain fast Fourier transform (FFT) across a large number of directions is computationally intensive and leads to high chip area and power consumption. We address this issue by exploiting recently proposed approximate discrete Fourier transforms (ADFT) which has its own sparse factorization for real-time implementation at low complexity and power consumption. The ADFT is used to create a wideband multi-beam RF digital beamformer and temporal spectrum-based attention unit which monitors 32~discrete directions across 32~sub-bands in real-time using a multiplierless algorithm having low computational complexity. The output of this spectral attention unit is applied as a decision variable to an intelligent receiver that adapts its center frequency and frequency resolution via FFT channelizers that are custom-built for real-time monitoring at high resolution. This two-step process allows the fine-gain FFT to be applied only to directions and bands of interest as determined by the ADFT based low-complexity 2D spacetime attention unit. The fine-grain FFT provides a spectral signature that can find future use cases in neural network engines for achieving modulation recognition, IoT device identification, and RFI identification. Beamforming and spectral channelization algorithms, digital computer architecture, and early prototypes using a 32-element fully digital multichannel receiver and field programmable gate array (FPGA)-based high-speed software defined radio (SDR) is provided.

Preprint ARTICLE | doi:10.20944/preprints201812.0289.v1

Latitudinal and Cross-Shelf Patterns of Size, Growth and Mortality of a Tropical Damselfish Acanthochromis polyacanthus on the Great Barrier Reef

Michael Kingsford, David Welch, Mark O'Callaghan

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: reef fish, age, growth, mortality, Great Barrier Reef, Pomacentridae, cross-shelf, MPA, latitudinal gradients.

Online: 24 December 2018 (15:36:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.0457.v1

Morphological and Genetic Assessment of Invasive Corbicula Lineages in Southern South America: A Case Study in Argentina

Leandro Andrés Hünicken, Esteban Marcelo Paolucci, Pablo Damian Lavinia, Francisco Sylvester

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Corbicula; Morphology; COI; Argentina; Distribution

Online: 8 May 2024 (10:34:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0866.v2

A Comprehensive Review of Current Developments and Future Outlook Pertaining to Electronic Medical Records in the Context of Saudi Arabia, Aimed at Enhancing the Healthcare System

Muhammad Usman Hassan Siddiqui, Faisal Majeed

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: electronic medical records; saudi arabia; health care system; block chain

Online: 16 October 2023 (16:57:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0904.v1

Identifying Antagonistic Rhizobacterial Strains with Biocontrol Potential against Cercospora beticola and Assessing Their Growth-Promoting Effects on Beta vulgaris

Zakariae El Housni, Said Ezrari, Nabil Radouane, Abdessalem Tahiri, Abderrahman Ouijja, Khaoula Errafii, Mohamed Hijri

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Biological control; Cercospora beticola; Cercospora leaf spot; Plant-Growth Promoting Rhizobacteria; Sugar beet

Online: 16 February 2024 (10:25:57 CET)

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Cercospora beticola Sacc. is an ascomycete pathogen that causes Cercospora leaf spot in sugar beets (Beta vulgaris L.) and other related crops. The disease symptoms are characterized by circular lesions with an ash-gray centre and dark brown to purple margins on the leaves. It can lead to significant yield losses if not effectively managed. This study aims to characterize and assess the impact of bacterial biological control agents against C. beticola. Following a dual-culture screening, 18 bacteria exhibiting over 50% inhibition were selected, with six of them demonstrating more than 80% control. Identification of the bacteria was carried out through sequencing of the16S rDNA, revealing potentially 12 species belonging to six genera including Bacillus which was represented by four species. Additionally, the bacteria underwent in-depth characterization of biochemical and molecular properties, as well as plant-growth promotion. PCR detection of genes responsible for producing antifungal metabolites revealed that 83%, 78%, 89%, and 56% of the selected bacteria possessed the bacillomycin, iturin, fengycin, and surfactin encoding genes, respectively. Infrared spectroscopy analysis confirmed the presence of lipopeptide structure in the bacteria supernatant filtrate. Subsequently, the bacteria were assessed for their effect on sugar beet plants in controlled conditions. The bacteria exhibited notable capabilities, promoting growth in both roots and shoots, resulting in significant increases in root length, weight, and shoot length. The field experiment with four bacterial candidates demonstrated good performance against C. beticola compared to difenoconazole fungicide. These bacteria played a significant role in disease control, achieving a maximum efficacy of 77.42%, slightly below the 88.51% efficacy attained by difenoconazole. Additional field trials are necessary to verify the protective and growth-promoting effects of these candidates, whether applied individually, combined in consortia, or integrated with chemical inputs in sugar beet crop production.

Preprint ARTICLE | doi:10.20944/preprints202305.0156.v1

Genotypic Response of Finger Millet to Zinc and Iron Agronomic Biofortification, Location and Slope Position Towards Yield

Demeke Teklu Senbetu, Dawd Gashu, Edward M. Joy, Murry R. Lark, Elizabeth H. Bailey, Lolita Wilson, Tilahun Amede, Martin R. Broadley

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Agronomic biofortification; finger millet; genotype; mineral fertilizer; yield

Online: 3 May 2023 (13:00:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1220.v1

Volatile Characterization of Recovery Minority Varieties from Castilla-La Mancha Region (Spain)

Cristina Cebrián-Tarancón, A.Sergio Serrano, Juan L. Chacón-Vozmediano, Jesús Martínez-Gascueña, Gonzalo L. Alonso

Subject: Biology And Life Sciences, Plant Sciences Keywords: recovered grapevine cultivars; aroma compounds; aroma potential; water stress

Online: 18 April 2024 (11:04:19 CEST)

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Preprint SHORT NOTE | doi:10.20944/preprints202401.0874.v1

Looking Drop-Dead Gorgeous or Throwing Yourself Towards Death:- The Pros and Cons of Cosmetic Surgery

Dev Desai, Maria Eleni Malafi

Subject: Medicine And Pharmacology, Surgery Keywords: Aesthetic; Medical ethics; Plastic surgery; advantages; disadvantages

Online: 11 January 2024 (13:01:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202304.0634.v1

Flow and Pressure Drop Characteristics of Methane/Ethane Mixture in the Spiral Tube under Sloshing Condition

Fengzhi Li, Zhongyun Tian, Yiqiang Jiang, Wenke Zheng, Jie Chen, Shulei Li

Subject: Engineering, Energy And Fuel Technology Keywords: Advanced manufacture; Energy security; Heat exchange; Cleaan energy

Online: 20 April 2023 (08:40:32 CEST)

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Preprint SHORT NOTE | doi:10.20944/preprints202307.0731.v2

Why No PlaneWaves of Macroscopic Bodies? A Micro-Macro Threshold?

Ladislaus Banyai

Subject: Physical Sciences, Theoretical Physics Keywords: center of mass; wave-package; plane wave; macroscopic; microscopic

Online: 10 July 2024 (10:42:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0266.v1

Peritoneal Dialysis Induced Encapsulating Peritonitis – Diagnostic and Therapeutic Challenges in Women with Benign Gynecological Pathology

Cristian Iorga, Cristina Raluca Iorga, Iuliana Andreiana, Simona Hildegard Stancu, Traian Constantin, Victor Strambu

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: peritoneal sclerosis; encapsulating peritonitis; emergency surgery

Online: 3 April 2024 (08:33:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0241.v1

Cell Response on Laser-Patterned Ti/Zr/Ti and Ti/Cu/Ti Multilayer Systems

Suzana Petrović, Nevena Božinović, Vladimir Rajić, Danijela Stanisavljevic Ninkovic, Danilo Kisić, Milena J Stevanović, Emmanuel Stratakis

Subject: Chemistry And Materials Science, Surfaces, Coatings And Films Keywords: multilayer thin films; laser modification; laser-induced periodical surface structure LIPSS; cell response

Online: 4 May 2023 (08:53:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0531.v1

Applying Stamping Without Die to Micro-hole Array Processing

Yung Chou Hung, Ching Yun Hsu

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: stamping without die; precision positioning; micro-hole array

Online: 19 April 2023 (03:34:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201903.0127.v1

Focal Plane Array Infrared Imaging of Linear Polymeric Patterns

Reo Honda, Meguya Ryu, Masayuki Moritake, Armandas Balcytis, Vygantas Mizeikis, Jitraporn Vongsvivut, Mark Tobin, Dominique Appadoo, Jing-Liang Li, Soon Hock Ng, Saulius Juodkazis, Junko Morikawa

Subject: Chemistry And Materials Science, Nanotechnology Keywords: focal plane array, thermal source, synchrotron radiation, infrared spectroscopy, hyperspectral imaging, silk, SZ2080

Online: 11 March 2019 (09:38:21 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202407.2052.v1

Novel De Novo RAI1:c.2736delC Variant Identified in A Child with Features of Smith-Magenis: Insight from Whole Genomes Joint Analysis

Mario Cuk, Busra Unal, Nives Jandric, Connor P. Hayes, McKenzie Walker, Kristina Crkvenac Gornik, Feruza Abraamyan, Arezou A. Ghazani

Subject: Biology And Life Sciences, Other Keywords: Smith-Magenis syndrome; retinoic acid-induced 1 protein; neurodevelopmental disorders; joint whole genome sequencing analysis ; ;

Online: 26 July 2024 (11:45:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1145.v1

Temperature-Driven Instabilities in High-Pressure Vessel Flat Plates: A Thermal Buckling Study

Alireza Sadeghi Chahardeh, Farima Abdollahi Mamoudan

Subject: Engineering, Mechanical Engineering Keywords: thermal buckling; high-pressure vessels; temperature-induced deformation; temperature effects; structural instability

Online: 15 July 2024 (10:52:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0060.v1

An Investigation of Surface Stress on the Fracture Mechanics Behavior of Classical and Phase-Separating Planar Electrodes

Seyed Ali Mahmoudy, Hamed Haftbaradaran

Subject: Engineering, Mechanical Engineering Keywords: Lithium-ion batteries; phase-separation; fracture mechanics; surface stress; diffusion-induced stresses

Online: 3 November 2021 (08:07:05 CET)

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Preprint ESSAY | doi:10.20944/preprints202209.0351.v1

Efects of a S-Metolachlor Based Herbicide on Two Plant Models: Zea Mays L. And Lactuca Sativa L.

Quenia Mara Silva, Marcel José Palmieri, Larissa Fonseca Andrade-Vieira

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Fitotoxicity; Seedling development; Germination; Micronuclei; Citotoxicity; Genotoxicity.

Online: 23 September 2022 (02:09:04 CEST)

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Working Paper ARTICLE

Protective Effects of GIC and S-PRG Filler Restoratives on Demineralization of Bovine Enamel in Lactic Acid Solution

Naoyuki Kaga, Futami Nagano-Takebe, Takashi Nezu, Takashi Matsuura, Kazuhiko Endo, Masayuki Kaga

Subject: Chemistry And Materials Science, Biomaterials Keywords: pH neutralization; ion release; enamel demineralization; glass ionomer cement; surface pre-reacted glass ionomer filler

Online: 5 May 2020 (04:22:41 CEST)

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Preprint CONFERENCE PAPER | doi:10.20944/preprints201612.0045.v2

Constraints on Dark Energy Models from Selected Galaxy Clusters (S-Z + X-Ray Data) and Gravitational Lensing Data

Alexander Bonilla Rivera, Jairo Ernesto Castillo Hernandez

Subject: Physical Sciences, Atomic And Molecular Physics Keywords: Sunyaev-Zeldovich effect, galaxy clusters, dark energy models

Online: 10 December 2016 (08:24:22 CET)

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Preprint REVIEW | doi:10.20944/preprints202404.0915.v1

A Review of Utilizing Electrochemical Impedance Spectroscopy on the Degradation of Lithium-Ion Batteries

Jun yang Leong

Subject: Engineering, Electrical And Electronic Engineering Keywords: batteries; ecm; eis; modelling

Online: 15 April 2024 (07:31:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201910.0310.v1

Impact of Swift Heavy Ion (120 MeV, Ag⁹⁺) on Doped ZnO: Al Thin Film

Lakhmikanta Mishra, Vishvas Kumar, Udai Pratap Singh

Subject: Chemistry And Materials Science, Surfaces, Coatings And Films Keywords: ZnO:Al; Swift heavy ion; XRD; AFM; Hall measurement

Online: 27 October 2019 (15:40:24 CET)

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Working Paper ARTICLE

DSRNet: A Novel Feature Extraction Network Achieving Trade off between Accuracy and Speed

Laigan Luo, Hailan Kuang, Xinhua Liu, Xiaolin Ma

Subject: Computer Science And Mathematics, Computer Science Keywords: depthwise; dilated; neural network; network complexity

Online: 14 September 2019 (12:40:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0203.v1

Molecular Cloning and Expression Analysis of COX II from Sitophilus zeamais, a Potential Action Site of AITC

Changliang Hou, Jingbo Wang, Hua Wu, Jiayu Liu, Zhiqing Ma, Juntao Feng, Xing Zhang

Subject: Biology And Life Sciences, Insect Science Keywords: Sitophilus zeamais; COXⅡ; Soluble proteins; Enzyme activity; AITC

Online: 25 August 2016 (10:11:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0192.v1

Statistical Structure and Deviations from Equilibrium in Wavy Channel Turbulence

Saadbin Khan, Balaji Jayaraman

Subject: Engineering, Mechanical Engineering Keywords: roughness; wall turbulence; direct numerical simulation; wavy surface

Online: 16 July 2019 (08:22:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0039.v1

Examination of Multiband IFA for UHF and SHF Channel Applications

Erfan Rohadi, Amalia Amalia, Indrazno Siradjuddin, Ferdian Ronilaya, Rosa Andrie Asmara

Subject: Engineering, Electrical And Electronic Engineering Keywords: inverted F antenna; near field; radiation pattern; parasitic element; multiband

Online: 3 April 2018 (15:56:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1654.v1

Experimental Investigation of Liquid Holdup in a Co-Current Gas Liquid Upflow Moving Packed Bed Reactor with Porous Catalyst Using Gamma Ray Densitometry

Ali Toukan, Ahmed Jasim, Vineet Alexander, Hamza AlBazzaz, Muthanna Al-Dahhan

Subject: Engineering, Chemical Engineering Keywords: upflow moving packed bed reactor; line average liquid holdup; gamma ray densitometry; porous catalyst

Online: 27 November 2023 (10:20:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0280.v1

Phytoextraction Potential of Flax Grown on Multimetal Contaminated Soils: A Field Experiment

Danai Kotoula, Eleni G. Papazoglou, Garyfallia Economou, Panayiotis Trigas, Dimitris L. Bouranis

Subject: Environmental And Earth Sciences, Pollution Keywords: heavy metals; Linum usitatissimum; nitrogen fertilization; phytoremediation; sowing period; uptake

Online: 5 March 2024 (16:05:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.1728.v1

Herbivory and Invasive Plant Species dynamics in Protected Rangelands: A Case for Conservation of Hell’s Gate National Park, Kenya

Moses K. Gichure, Justine M. Nyaga, Rossa N. Ngendo, Franklin N. Nyabuga

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Mammalian herbivory; Vegetation dynamics; Ground cover vegetation; Invasive Plants; Hell’s Gate National Park

Online: 25 July 2023 (13:12:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202102.0230.v1

Astrocytes in Alzheimer´s Disease: Pathological Significance and Molecular Pathways

Pranav Preman, Maria Alfonso-Triguero, Elena Alberdi, Alexej Verkhratsky, Amaia M Arranz

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Astrocyte, Alzheimer´s disease, neurodegeneration, transcriptomics, RNA sequencing (RNA-seq), cellular states.

Online: 9 February 2021 (10:04:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.0253.v1

Title Time-Series Analysis of Slope Displacements Using UAV Photogrammetry and Its Relationship With Rainfall Intensity

Byonghee Jun, Renato Macciotta, Namgyun Kim

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: Slope displacement; UAV; DSM; Rainfall intensity

Online: 5 June 2023 (07:34:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2357.v1

Field Ion Microscopy of Tungsten Nano-Tips Coated with Thin Layer of the Epoxy Resin

Dinara Sobola, Ammar Alsoud, Alexandr Knápek, Marwan Mousa, Richard Schubert, Pavla Kočková, Pavel Škarvada

Subject: Physical Sciences, Condensed Matter Physics Keywords: Field ion emission; tungsten atomic distribution; epoxy molecular distribution; composite field emitter; composite electron sources

Online: 30 July 2024 (07:41:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0185.v1

Design, Fabrication and Analysis of Threshold-Value Judging Mechanism in MEMS Safety and Arming Device

Dakui Wang, Wenzhong Lou, Yue Feng, Fufu Wang

Subject: Engineering, Mechanical Engineering Keywords: MEMS S&A device; threshold-value judging mechanism; fabrication process; tensile test; theoretical, simulationand experimentalanalysis; parametric design method

Online: 24 March 2017 (10:12:13 CET)

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Preprint ARTICLE | doi:10.3390/sci1010007.v1

Quantum Calcium-Ion Interactions with EEG

Lester Ingber

Subject: Computer Science And Mathematics, Computer Science Keywords: quantum mechanics; EEG; short term memory; astrocytes; neocortical dynamics; vector potential

Online: 11 December 2018 (00:00:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.2010.v1

The Effect of Cluster Nursing in ICU on Treatment Compliance and Intestinal Barrier Function in Patients with Refractory Septic Shock

Yun Chen, Yuefang Pan, Shunbo Xu

Subject: Medicine And Pharmacology, Surgery Keywords: care bundles; ICU; refractory septic shock; treatment compliance; intestinal barrier function

Online: 31 July 2023 (02:34:58 CEST)

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Objective: To evaluate the effect of care bundles on treatment compliance and intestinal barrier function in patients with refractory septic shock in the intensive care units (ICUs). Methods: In this retrospective study, the clinical data of 94 patients with refractory septic shock admitted to our hospital between June 2020 and April 2022 were collected. Patients with routine nursing were included in the routine group, and those with care bundles were assigned to the care bundles group, with 47 cases in each group. Outcome measures included nursing efficiency, treatment compliance, sequential organ failure assessment (SOFA) score, acute physiology and chronic health evaluation (APACHE II) score, intestinal barrier function, inflammation factor level, treatment outcome and complications. Results: Care bundles resulted in significantly higher nursing efficiency and treatment compliance versus routine care (P<0.05). Patients receiving care bundles showed significantly higher SOFA scores and APACHE II scores than those receiving routine care (P<0.05). Intestinal fatty-acid binding protein (I-FABP), diamine oxidase (DAO), lactate, endotoxin, and intestinal dysfunction scores in the care bundles group were significantly lower than those in the conventional group after treatment (P<0.05). Care bundles were associated with significantly lower levels of procalcitonin (PCT) and hypersensitive C-reactive protein (hsCRP), shorter time to symptom relief, ICU treatment time, and duration of mechanical ventilation, and lower 28-d morbidity and mortality versus routine care (P<0.05). Patients in the care bundles group had a significantly lower incidence of complications than those in the routine group (P<0.05). Conclusion: Care bundles effectively enhance treatment compliance, improve intestinal barrier function and treatment outcomes, reduce the inflammatory response, and decrease the risk of SOFA score, APACHE II score, and complications in patients with refractory septic shock.

Preprint ARTICLE | doi:10.20944/preprints202307.1594.v1

The Effect of Cluster Nursing in ICU on Treatment Compliance and Intestinal Barrier Function in Patients with Refractory Septic Shock

Yun Chen, Yuefang Pan, Shunbo Xu

Subject: Medicine And Pharmacology, Surgery Keywords: Care bundles; ICU; Refractory septic shock; Treatment compliance; Intestinal barrier function

Online: 24 July 2023 (10:30:31 CEST)

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Objective: To evaluate the effect of care bundles on treatment compliance and intestinal barrier function in patients with refractory septic shock in the intensive care units (ICUs). Methods: In this retrospective study, the clinical data of 94 patients with refractory septic shock admitted to our hospital between June 2020 and April 2022 were collected. Patients with routine nursing were included in the routine group, and those with care bundles were assigned to the care bundles group, with 47 cases in each group. Outcome measures included nursing efficiency, treatment compliance, sequential organ failure assessment (SOFA) score, acute physiology and chronic health evaluation (APACHE II) score, intestinal barrier function, inflammation factor level, treatment outcome and complications. Results: Care bundles resulted in significantly higher nursing efficiency and treatment compliance versus routine care (P<0.05). Patients receiving care bundles showed significantly higher SOFA scores and APACHE II scores than those receiving routine care (P<0.05). Intestinal fatty-acid binding protein (I-FABP), diamine oxidase (DAO), lactate, endotoxin, and intestinal dysfunction scores in the care bundles group were significantly lower than those in the conventional group after treatment (P<0.05). Care bundles were associated with significantly lower levels of procalcitonin (PCT) and hypersensitive C-reactive protein (hsCRP), shorter time to symptom relief, ICU treatment time, and duration of mechanical ventilation, and lower 28-d morbidity and mortality versus routine care (P<0.05). Patients in the care bundles group had a significantly lower incidence of complications than those in the routine group (P<0.05). Conclusion: Care bundles effectively enhance treatment compliance, improve intestinal barrier function and treatment outcomes, reduce the inflammatory response, and decrease the risk of SOFA score, APACHE II score, and complications in patients with refractory septic shock.

Preprint ARTICLE | doi:10.20944/preprints202406.0932.v1

Cheiloscopic Evaluation in Forensic Odontostomatology: Exploring Potential and Limitations

Emanuele Di Vita, Davide Albano, Andrea Trizzino, Fabio Massimo Sciarra, Simone Vintrici, Lorenzo Reali, Enzo Cumbo, Giuseppa Bilello, Stefania Zerbo, Antonella Argo, Pietro Messina, Giuseppe Alessandro Scardina

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Cheiloscopy; Forensic dentistry; Lip prints; Sex.

Online: 13 June 2024 (14:55:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0617.v1

Colchicine-Induced Double Haploid Production of Spring Bread Wheat (Triticum aestivum L.) via Wheat × Maize Hybridization

Md. Forhad Amin, Mohammad Nur Alam, Golam Faruq, Md. Mustafa Khan, Md. Mahbubur Rahman

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Colchicine; Conventional breeding method; Double haploid; Spring bread wheat; wheat ×; maize hybridization

Online: 9 September 2024 (08:42:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1510.v1

Lactate-Induced HBEGF Shedding and EGFR Activation: Paving the Way to a New Anticancer Therapeutic Opportunity

Valentina Rossi, Alejandro Hochkoeppler, Marzia Govoni, Giuseppina Di Stefano

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: cancer cell metabolism; lactate; EGFR; HBEGF

Online: 19 July 2024 (12:01:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1666.v1

COMPARE CABG: A Meta-Analysis of Comparative Outcomes in On-Pump vs. Off-Pump Coronary Artery Bypass Grafting

José Victor da Nóbrega Borges, Samira Abdel Correia Leila, Manuella Guedes da Nóbrega Machado

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Cardiac Surgery; Coronary Artery Bypass Grafting; Coronary Heart Disease

Online: 24 June 2024 (13:48:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.2506.v1

Metabolic function and Therapeutic Potential of CD147 for Hematological Malignancies: An Overview

Isabella Spinello, Catherine Labbaye, Ernestina Saulle

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Hematological Malignancies; Metabolism; CD147

Online: 31 July 2024 (11:07:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0225.v1

Investigation of Laminar-Turbulent Transition on a Rotating Wind Turbine Blade of Multi Megawatt Class with Thermography and a Microphone Array

Torben Reichstein, Alois Peter Schaffarczyk, Christoph Dollinger, Nicolas Balaresque, Erich Schuelein, Clemens Jauch, Andreas Fischer

Subject: Engineering, Energy And Fuel Technology Keywords: boundary layer transition; wind turbine; thermography; aerodynamic glove

Online: 19 April 2019 (11:58:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1845.v1

Retrospective Radiographic Analysis of Peri-Implant Bone Loss in Mandibular Full-Arch Implant Rehabilitations

Francesco Giordano, Alfonso Acerra, Roberta Gasparro, Marzio Galdi, Francesco D’Ambrosio, Mario Caggiano

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: bone loss around implants; implant-supported prosthetic rehabilitation; mandibular flexure; mandibular full-arch

Online: 26 August 2024 (13:14:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1888.v1

Molecular Mechanism and Signal Transduction of Resistance to Low-Temperature Stress Induced by Bacillus amyloliquefaciens GL18 in Avena sativa

Lan Chen, Tian Wang, Ying Zhang, Yongli Xie, Feifei Chang, Lingling Wu, Ying Gao, Junxi Li

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: low-temperature stress; Bacillus amyloliquefaciens; ‘ Qingyan 1’ ; transcriptome; signal transduction pathway analysis

Online: 27 August 2024 (15:34:47 CEST)

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Bacillus amyloliquefaciens GL18 has been proven to have good resistance ability and can promote the growth of Avena sativa cultivar ‘Qingyan 1’. Herein, Illumina high-throughput transcriptome sequencing technology was used to analyze the differential expression of genes between the interaction group (LB) and the control group (LCK) when ‘Qingyan 1’ roots interacted with GL18 bacterial suspension or sterile water for 12 h under 4 °C low-temperature stress. The gene function annotation information was obtained using Gene Ontology (GO) functional classification and enrichment analysis. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and annotation of differentially expressed genes was used to explore the related signal transduction pathway of ‘Qingyan 1’ response to cold stress induced by Bacillus GL18. The results showed that after ‘Qingyan 1’ seedlings interacted with GL18 bacterial suspension or sterile water for 12 h, comparing the LB with the LCK or CK (the control group at 26 °C), there were 12,061 and 25,489 differentially expressed genes, respectively. Their functions were mainly related to metabolic process, cellular process, catalytic activity, binding, and cellular parts, and they were significantly enriched in plant tissue growth and development, cell wall, organelle membrane synthesis, thiamine and its compounds, biosynthesis, polyamine decomposition, and other metabolic processes. Signal transduction was detected through KEGG pathway enrichment analysis, and corresponding genes, such as AUXI, PP2C, SNRK2, ABF, BRI1, and PIF4, were expressed. The expression of genes directly involved in plant growth was upregulated in the presence of GL18, as shown by real-time quantitative PCR analysis. It was speculated that the normal growth and development of ‘Qingyan 1’ under low-temperature stress promoted by GL18 is a result of the integration of multiple pathways in terms of regulating endogenous hormone metabolism, secondary metabolite synthesis, and photosynthesis.

Preprint REVIEW | doi:10.20944/preprints202404.0607.v1

Microplastics from the Mediterranean Sea and Atlantic Ocean. Functional and Clinical Endocrine Exposure to Human Health. Systematic Review.

José Antonio Latorre, Javier Conde-Pipó, Alba Diaz, Alejandro Lopez-Moro, Nuria Gimenez-Blasi, Nicolas Olea, Fatima Olea-Serrano, Miguel Mariscal-Arcas

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Microplastics; endocrine disruptors; endocrine exposure; plastics; Mediterranean Sea; human health.

Online: 9 April 2024 (08:56:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0459.v1

Basin Entropy and Shearless Barrier Breakup in Open Non-Twist Hamiltonian Systems

Leonardo Costa De Souza, Amanda Carolina Mathias, Pedro Haerter, Ricardo Luiz Viana

Subject: Physical Sciences, Fluids And Plasmas Physics Keywords: basin entropy; shearless barriers; non-twist maps; open Hamiltonian systems

Online: 7 July 2023 (07:09:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0279.v1

In silico tool for predicting and designing Blood-Brain Barrier Penetrating Peptides

Vinod Kumar, Sumeet Patiyal, Anjali Dhall, Neelam Sharma, Gajendra Pal Singh Raghava

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Blood-Brain Barrier, Penetrating Peptides, Machine learning techniques, Drug delivery, Therapeutic peptides

Online: 10 June 2021 (08:13:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0146.v9

A Proof of the Riemann Hypothesis Based on MacLaurin Expansion and Hadamard Product of the Completed Zeta Function

Weicun Zhang

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Riemann Hypothesis (RH); Proof; Completed zeta function $\xi(s)$

Online: 14 October 2021 (14:14:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0198.v1

On p-common Best Proximity Point Results for S-weakly Contraction in Complete Metric Spaces

Chayut Kongban, Somayya Komal, Poom Kumam

Subject: Computer Science And Mathematics, Analysis Keywords: P-common best proximity point, weak Pp-property, S-weakly contraction.

Online: 11 September 2018 (12:26:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0140.v1

Influence of Alkali Metal Substitution on the Phase Transition Behavior of CsGaQ2 (Q = S, Se)

Daniel Friedrich, Marc Schlosser, Martin Etter, Arno Pfitzner

Subject: Chemistry And Materials Science, Inorganic And Nuclear Chemistry Keywords: chalcogenogallates; polymorphism; solid solutions; in situ X-ray diffraction; synchrotron radiation; rietveld refinement

Online: 20 October 2017 (12:53:24 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202404.0110.v1

Dramatic Wound Closing Effect of a Single Application of iBTA-Induced Autologous Biosheet on Severe Diabetic Foot Ulcers Involving Heel Area

Ryuji Higashita, Yasuhide Nakayama, Manami Miyazaki, Yoko Yokawa, Ryosuke Iwai, Marina Iwai

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Diabetic foot ulcer; Tissue-engineered biosheet; in-body tissue architecture; wound repaire

Online: 1 April 2024 (15:00:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1963.v1

How Trustworthy Are Genomic Sequences of SARS-CoV-2 in GenBank?

Xuhua Xia

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: SARS-CoV-2; COVID-19; GenBank; data validation; genome; genomic analysis

Online: 28 August 2024 (12:37:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0745.v1

Synthesis and Characterization of Polyaniline Emeraldine Salt (PANI-ES) Colloids Using Potato Starch as a Stabilizer, to Enhance the Physicochemical Properties and Processibility

Soufiane Boudjelida, Xue Li, Souad Djellali, Giampiero Chiappetta, Francesca Russo, Alberto Figoli, Mauro Carraro

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: starch; polyaniline; Stabilizer; Composites; Conductive Colloids

Online: 11 April 2024 (04:05:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1717.v1

Formulation and Characterization of DES and Potential Application in Recycling Packaging Laminates

Adamantini Loukodimou, Christopher Lovell, Tianmiao Li, George Theodosopoulos, Kranthi Kumar Maniam, Shiladitya Paul

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: DES; laminate packaging materials; blister packs; recycle; carboxylic acids; delamination

Online: 23 August 2024 (10:31:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1936.v1

Microbial Consortium of Jeju Traditional Fermented Foods and Their Cosmetic Ingredient Potential

Sung-Eun Bae, Sungmin Bae, Sung Jin Park, Pomjoo Lee, Chang-Gu Hyun

Subject: Biology And Life Sciences, Food Science And Technology Keywords: B16F10 melanoma; Jeju traditional fermented foods; macrophage; melanin; nitric oxide; skin irritation

Online: 29 May 2024 (07:51:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1959.v1

FireSonic: Design and Implementation of an Ultrasound Sensing-Based Fire Type Identification System

Zheng Wang, Yanwen Wang, Mingyuan Liao, Yi Sun, Shuke Wang, Xiaoqi Sun, Xiaokang Shi, Yisen Kang, Mi Tian, Tong Bao, Ruiqi Lu

Subject: Computer Science And Mathematics, Signal Processing Keywords: Acoustic sensing; channel measurements; fire type classification; beamforming

Online: 27 June 2024 (18:39:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0424.v1

Entropic Ranks: A Methodology for Enhanced, Threshold-Free, Information-Rich Data Partition and Interpretation

Hector - Xavier de Lastic, Irene Liampa, Alexandros G. Georgakilas, Michalis Zervakis, Aristotelis Chatziioannou

Subject: Computer Science And Mathematics, Data Structures, Algorithms And Complexity Keywords: data analysis; threshold-free; differential analysis

Online: 18 September 2020 (09:11:04 CEST)

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Background: Traditional omic analysis relies on p-value and fold change as selection criteria. There is an ongoing debate on their effectiveness in delivering systemic and robust interpretation, due to their dependence on assumptions of conformity with various parametric distributions.Here, we propose a threshold-free selection method based on robust, non-parametric statistics, ensuring independence from the statistical distribution properties and broad applicability. Such methods could adapt to different initial data distributions, contrary to statistical techniques based on fixed thresholds. Methods: Our work extends the Rank Products methodology with a neutral selection method of high information-extraction capacity. We introduce the calculation of the RP distribution’s entropy to isolate the features of interest by their contribution to the distribution’s information content. The aim is a methodology performing threshold-free identification of the differentially expressed features, which are highly informative about the phenomenon under scrutiny. Conclusions: Applying the proposed method on microarray (transcriptomic and DNA methylation) and RNAseq count data of varying sizes and noise presence, we observe robust convergence for the different parameterisations to stable cutoff points. Functional analysis through BioInfoMiner and EnrichR was used to evaluate the information potency of the resulting feature lists. Overall, the derived functional terms provide a systemic description highly compatible with the results of traditional statistical hypothesis testing techniques. The methodology behaves consistently across different data types. The feature lists are compact and information-rich, indicating phenotypic aspects specific to the tissue and biological phenomenon i nvestigated. Selection by information content measures efficiently addresses problems, emerging from arbitrary thresholding, thus facilitating the full automation of the analysis.

Preprint ARTICLE | doi:10.20944/preprints202005.0458.v2

Cost-sensitive Ensemble Feature Ranking and Automatic Threshold Selection for Chronic Kidney Disease Diagnosis

Syed Imran Ali, Bilal Ali, Jamil Hussain, Musarrat Hussain, Fahad Ahmed Satti, Gwang Hoon Park, Sungyoung Lee

Subject: Computer Science And Mathematics, Computer Science Keywords: Cost-sensitive feature selection; ensemble models; decision tree classifiers; chronic kidney disease; random forests; gradient boosted trees

Online: 6 July 2020 (09:56:15 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints201808.0126.v2

Injury threshold of oral contact with hot foods and method for its sensory evaluation

Dirk W. Lachenmeier, Walter Lachenmeier

Subject: Chemistry And Materials Science, Food Chemistry Keywords: hot foods; temperature; esophageal cancer; thermosensing; sensory thresholds; methodological study

Online: 9 August 2018 (12:50:40 CEST)

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Epidemiological studies indicate an increased risk of cancer from the consumption of very hot foods and beverages. The International Agency for Research on Cancer (IARC) has already recommended threshold values for the maximum drinking temperature of very hot beverages. The contact time and the contact temperature are decisive for the risk of injury when hot media come into contact with human skin. However, measuring the contact temperature is not easily possible in practice. In the present study, a numerical simulation based on the solution of the heat conduction equation was initially used to investigate whether and for what period of time a constant contact temperature is to be expected under oral conditions. For small circular 3-cm food samples (e.g., cooked potatoes) with 2.5 mm thickness in contact with the tongue, the simulation results in a constant contact temperature of 10 s before cooling. With a thickness of 0.5 mm, the contact temperature is only maintained 1 s. Hot beverages, which spread as a thin film and thereby increase their surface area, can therefore be consumed at higher temperatures than solid foods. Furthermore, a simple test technique with a "measuring spoon" was developed. A hot sample is placed on the tongue. Orientating measurements were used to determine which contact temperature was considered to be just comfortable for any period > 10 s and for which period of less than 10 s it was still just bearable. The contact temperature, which was still perceived as tolerable for periods > 10 s, was 46.5 °C. The time spans for the higher contact temperature 48 °C were between 2 and 4 s and for 49 °C between 1 and 2 s. The course of the contact temperatures determined in the experiment over time allows to calculate the corresponding threshold values of consumption temperatures for various foods. Consumption temperatures of about 56 °C for potatoes and 60 °C for cheese are still perceived as tolerable. In view of the fact that the contact temperature is obviously the determining factor for the risk of injury from burns in the oral cavity in addition to the contact time, it makes sense to reference threshold values to the contact temperature rather than to the surface or consumption temperature of a food product, which is current customary practice. If this contact temperature is defined as a threshold value, the surface or consumption temperature for any other food can be calculated.

Preprint REVIEW | doi:10.20944/preprints202202.0011.v1

Leveraging Beneficial Off-target Effects Of Live-attenuated Rotavirus Vaccines

Prisca Benedicto-Matambo, Julie Bines, Chikondi Malamba-Banda, Isaac Tom Shawa, Kayla Barnes, Arox Wadson Kamn’gona, Daniel Hungerford, Kondwani Charles Jambo, Miren Iturriza-Gomara, Nigel A. Cunliffe, Katie L Flanagan, Khuzwayo Chidiwa Jere

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Rotavirus; off-target effects; neonatal; live attenuated; RV3-BB; epigenetic modulation

Online: 1 February 2022 (12:34:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0017.v1

A Static Hybrid Renewable Energy System for Off-Grid Supply

Augusto Montisci, Marco Caredda

Subject: Engineering, Automotive Engineering Keywords: Energy static conversion; Off-grid supply; Thermoacoustics; HRES

Online: 2 August 2021 (11:12:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1543.v1

Random Convolutional Kernel Transform with Empirical Mode Decomposition for Medium Voltage Insulator Classification based on Ultrasound Sensor

Anne Carolina Rodrigues Klaar, Laio Oriel Seman, Viviana Cocco Mariani, Leandro dos Santos Coelho

Subject: Engineering, Electrical And Electronic Engineering Keywords: Electric Power System; Empirical Mode Decomposition; Rocket Algorithm; Time Series Classification.

Online: 22 January 2024 (09:52:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints201812.0172.v1

Region Asymmetric Polymers Based on Fluorinated Benzothiadiazole-Benzodithiophene for Polymer Solar Cells with High Open-Circuit Voltage

Caijun Liu, Guoyue Gan, Zhanfeng Li, Na Sun, Xueqiao Li, Yahui Tong, Hua Wang, Yuying Hao

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: polymer solar cells; region asymmetric polymers; fluorinated benzothiadiazole

Online: 14 December 2018 (09:56:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints201805.0241.v1

Impact of Plug-in Electric Vehicles Integrated into Power Distribution System based on Voltage Dependent Power Flow

Yuttana Kongjeen, Krischonme Bhumkittipich

Subject: Engineering, Electrical And Electronic Engineering Keywords: load flow analysis; load voltage deviation; plug-in electric vehicles load; power-flow analysis; static load models

Online: 17 May 2018 (10:24:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1721.v1

Transformation of DIY Geiger Counter Kits into a Muon Detector for Educational and Scientific Exploration

Marco Arcani, Domenico Liguori, Andrea Frassà, Altea Renata Maria Nemolato, Omar Del Monte, Cesare Guaita

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Muon detector; cosmic rays; DIY Geiger counter; educational tools; scientific exploration

Online: 27 May 2024 (09:56:07 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.1122.v1

Revisiting Clockwork Model: A Review of Theoretical Foundations and Experimental Progress

Gayatri Ghosh, Maxim Khlopov

Subject: Physical Sciences, Particle And Field Physics Keywords: clockwork fermions; mass hierarchies; dark matter; invisible axion; Beyond the Standard model

Online: 15 August 2024 (15:16:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2116.v1

Hydrodynamic Design and Array System Study of a New Floating Wave Energy Device

Yu Zhang, Dongqin Li

Subject: Engineering, Marine Engineering Keywords: Wave power generation; Oscillating float; Computational Fluid Dynamics; Array

Online: 30 September 2023 (07:55:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0030.v1

Screening of Nias World Rice Core Collection for Seeds with Long Longevity as Useful Potential Breeding Materials Focusing on the Stability of Embryonic RNAs

Kalimullah Saighani, Megumi Kashiwagi, Safiullah Habibi, Craig G. Simpson, Tetsuya Yamada, Motoki Kanekatsu

Subject: Biology And Life Sciences, Plant Sciences Keywords: world rice (Oryza sativa L.) core collection; seed longevity; embryonic RNA stability; RNA integrity number (RIN); controlled deterioration treatment (CDT); breeding materials

Online: 4 June 2024 (02:52:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.1549.v1

Cervical Cancer or Cervical Endometriosis – Review and Case Report

Carolina Gobjila, Doru Anastasiu, Izabella Petre, Zoran Laurentiu Popa, Anca Bordianu, Ion Petre, Marina Adriana Mercioni, Simona Ioana Sipos

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: cervical cancer; cervical endometriosis; conization; adenomyosis; cervical malignancy; infertility; HPV

Online: 22 August 2023 (10:49:33 CEST)

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According to cancer death rates for women worldwide, this form of cancer ranks fourth after breast, bronchopulmonary, and colorectal cancer, affecting around 570,000 women annually. About 270,000 women each year pass away from this illness, 85% of them are from underdeveloped nations where cervical cancer claims more lives than any other kind of cancer. In Romania, cervical cancer ranks fourth in terms of death, behind breast, bronchopulmonary, and colorectal cancers, and second in terms of incidence, behind breast cancer. Endometriosis in the cervical region is quite uncommon. Only a tiny fraction of women had the condition upon diagnosis. It might be challenging to detect cervical endometriosis since it rarely manifests any symptoms or markers. Women who are asymptomatic can manage the condition expectantly; however, if the symptoms return often, surgery may be required. As many patients have concurrent diseases such fibroids, adenomyosis, ovarian cysts, and pelvic endometriosis, cervical endometriosis therapy appears to be straightforward. There ought to be surgical intervention. Symptomatic cervical endometriosis, such as irregular or post-coital bleeding, may be treated surgically using the LLETZ surgery or another cervical ablation approach. Background and Objectives: (1) To assess one's degree of knowledge on the signs, causes, and methods of preventing cervical cancer or cervical endometriosis, as well as screening for these conditions. (2) To ascertain how the responder behaves about cervical cancer screening and prevention, as well as endometriosis in the cervical region. Materials and Methods: A case report about cervical cancer or cervical endometriosis was conducted among a patient from Romania, Timisoara. Results: In this study, we report the patient with cervical endometriosis, although he was initially diagnosed with cervical cancer. Conclusions: Cervical cancer, a condition that can have serious repercussions on the patient's health, even if there is no clear picture of paraclinical investigations, to raise the suspicion of cervical endometriosis and not cervical cancer.

Preprint ARTICLE | doi:10.20944/preprints202311.1246.v2

A Deep Learning Method for Health State Prediction of Lithium Ion Batteries Based on LUT-Memory and Quantization

Mohamed H. Al-Meer

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Lithium-Ion Batteries; SoH; SoC; RUL; Batteries; Deep Learning; LUT

Online: 3 January 2024 (09:43:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0099.v1

Effects of Restoration Strategies on the Ion Distribution and Transport Characteristics of Medicago sativa in Saline-Alkali Soil

Baole Yu, Lingling Chen, Taogetao Baoyin

Subject: Environmental And Earth Sciences, Ecology Keywords: Bio-fertilizer; Flue gas desulfurization gypsum; Humic acid; Ion metabolism; saline-alkali land

Online: 1 November 2023 (13:27:30 CET)

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Preprint REVIEW | doi:10.20944/preprints202307.0292.v1

Research Progress on the Structural Design and Optimization of Silicon Anodes for Lithium-Ion Batteries: A Mini-Review

Zhi Yu, Lijiang Cui, Bo Zhong, Guoxing Qu

Subject: Chemistry And Materials Science, Electrochemistry Keywords: lithium-ion batteries; silicon anode; structural optimization; surface structural; artificial SEI

Online: 5 July 2023 (12:34:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0410.v1

Influence of Ion Nitriding on Microstructure and Properties of Haynes 282 Nickel Alloy Specimens Produced using Additive Technique

Ryszard Sitek, Krzysztof Kulikowski, Krystian Paradowski, Kamil Gancarczyk, Akira Kobayashi, J. Moneta, Janusz Kamiński

Subject: Engineering, Mechanical Engineering Keywords: Haynes 282 nickel alloy; Additive manufacturing; Ion nitriding, Corrosion resistance, Microstructure, Static tensile test.

Online: 6 May 2023 (10:09:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0444.v2

Slope Safety Risk Analysis of The Embankments Made of Different Landfill-Mined Waste

Abhay Kumar Verma, Shivani Singh Dhriyan, Arun Prasad

Subject: Engineering, Civil Engineering Keywords: FEM; Slope Stability; Plaxis; MSW

Online: 2 August 2022 (07:43:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0118.v1

Predictive Simulation of Concurrent Debris Flow: How Slope Failure Locations Affect Predicted Damage

Kazuki Yamanoi, Satoru Oishi, Kenji Kawaike, Hajime Nakagawa

Subject: Engineering, Civil Engineering Keywords: debris flow; prediction; numerical simulation; high-performance computing; slope failure; sediment-laden flood; uncertainty analysis

Online: 8 April 2020 (05:08:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0364.v1

Channel Emulator Framework for Underwater Acoustic Communications

Indrakshi Dey, Nicola Marchetti

Subject: Computer Science And Mathematics, Logic Keywords: acoustic signals; underwater communications; channel impulse responses; Doppler frequencies; performance evaluation and monitoring; Simulink-based emulator

Online: 21 March 2023 (02:10:22 CET)

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Working Paper ARTICLE

Transitional Channel Flow: A Minimal Stochastic Model

Paul Manneville, Masaki Shimizu

Subject: Physical Sciences, Acoustics Keywords: transition to/from turbulence; wall-bounded shear flow; plane Poiseuille flow; spatiotemporal intermittency; directed percolation; critical phenomena

Online: 4 November 2020 (09:16:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints201901.0030.v1

Exploit Delivery using Steganography as Covert Channel

Tariq Khairallah

Subject: Computer Science And Mathematics, Computer Science Keywords: Steganography, exploitation, Malicious Code

Online: 3 January 2019 (14:35:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints201805.0053.v3

Effect of Fucoidan on Anterior Cruciate Ligament Transection and Medial Meniscectomy Induced Osteoarthritis in High-Fat Diet-Induced Obese Rats

Sabri Sudirman, Alan Darmasaputra Ong, Heng-Wei Chang, Zwe-Ling Kong

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: anterior cruciate ligament; fucoidan; meniscectomy; obesity; osteoarthritis

Online: 22 May 2018 (07:54:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1455.v1

GIPR Overexpression Reduces the Tumorigenic Potential of Retinoblastoma Cells

André Haase, Emily Alefeld, Fatma Yalinci, Dario Van Meenen, Maike Anna Busch, Nicole Dünker

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: retinoblastoma; RB; gastric inhibitory polypeptide receptor; GIPR; trefoil factor family peptide; TFF1; CAM; tumorigenesis; MK0893; miR5-542-5p

Online: 25 March 2024 (08:36:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202304.1007.v1

Combining low-cost SLAM and SfM-MVS for Rural and Forest Road-side Slope Erosion Control: a methodology

Christopher Gomez, Muhammad Anggri Setiawan, Noviyanti Listyaningrum, Balázs Bradák, Yousefi Saleh

Subject: Environmental And Earth Sciences, Soil Science Keywords: SfM-MVS; SLAM; roadside erosion; low-cost erosion measurement; slope erosion

Online: 27 April 2023 (02:41:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0618.v1

Validation of a Brief Screening Instrument for Chemical Intolerance in a large U.S. National Sample

Raymond F Palmer, Tatjana Walker, David Kattari, Rudy Rincon, Perales Roger, Calos Jaen, Carl Grimes, Dana R Sunblad, Claudia S Miller

Subject: Medicine And Pharmacology, Other Keywords: Chemical Intolerance, Drug Intolerance, Food Intolerance, QEESI, BREESI, Multiple Chemical Sensitivity, Toxicant-induced Loss of Tolerance, Prevalence

Online: 25 June 2021 (11:49:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0046.v1

Veratridine Can Bind to a Site at the Mouth of the Channel Pore at Human Cardiac Sodium Channel NaV1.5

Alican Gulsevin, Andrew M Glazer, Tiffany Shields, Brett M Kroncke, Dan M Roden, Jens Meiler

Subject: Biology And Life Sciences, Biophysics Keywords: voltage-gated sodium channels; cardiac sodium channels; SCN5A; veratridine; toxins; molecular docking; Rosetta; electrophysiology; site-directed mutagenesis

Online: 5 January 2022 (18:02:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.2076.v2

Electrical-Quantum Modelling of the Neutron and Proton as a Three-Phase Alternating Current Electrical Generator. Determination of the Number of Quarks-Antiquarks-Gluons and Gravitons, Inside a Neutron

Hector Gerardo Flores, Maria Isabel Gonçalves de Souza

Subject: Physical Sciences, Theoretical Physics Keywords: RLC electrical model; RC electrical model; cosmology; astronomy; astrophysics; background radiation; Hubble’ s law; Boltzmann´; s constant; dark energy; dark matter; black hole; Big Bang; cosmic inflation; early universe; quantum gravity; CERN; LHC; Fermilab; general relativity; particle physics; condensed matter physics; M theory; super string theory; extra dimensions

Online: 1 April 2024 (13:28:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1060.v1

Attenuation Correction of the X-Band Dual-Polarization Phased Array Radar Based on Observed Raindrop Size Distribution Characteristics

Jiabao Feng, Xiantong Liu, Feng Xia, Yu Zhang, Xiaona Rao

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: X-band dual-polarization phased array radar; Precipitation attenuation; Precipitation types; Raindrop size distributions

Online: 27 April 2023 (08:14:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0166.v1

Dual-Target Car-Ts With on- and off-Tumour Activity May Override Immune Suppression in Solid Cancers: A Mathematical Proof of Concept

Odelaisy León-Triana, Antonio Pérez-Martínez, Manuel Ramírez-Orellana, Víctor M. Pérez-García

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Mathematical oncology; CAR-T cells; mathematical immunology; mathematical modelling; immunotherapy of solid tumours; glioblastoma

Online: 7 December 2020 (15:06:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.0763.v1

SARS-CoV-2 Humoral and Cellular Immune Responses in HIV-Positive Patients

Simona Ruta, Corneliu Petru Popescu, Lilia Matei, Camelia Grancea, Adrian Marius Paun, Cristiana Oprea, Camelia Sultana

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; SARS-CoV-2; vaccination; cellular, humoral immune response; immunosuppression

Online: 13 May 2024 (11:11:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0256.v1

A Constant Voltage WPT System for Implantable Neural Stimulators

Zhiyang Cao, Shicong Gui, Chujia Xu, Rui Zhong, Zhaotan Lin, Yubo Li

Subject: Engineering, Electrical And Electronic Engineering Keywords: WPT; resonance inductive coupling; wireless neural stimulator; implant device

Online: 2 July 2024 (15:13:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.2343.v1

A Sub-1-V Nanopower MOS-Only Voltage Reference

Siqi Wang, Zhenghao Lu, Kunpeng Xu, Hongguang Dai, Zhanxia Wu, Xiaopeng Yu

Subject: Engineering, Electrical And Electronic Engineering Keywords: voltage reference; MOS-only; low power; low voltage; sub-threshold

Online: 30 December 2023 (16:23:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0495.v1

Increasing the Voltage – Sequencing Decarbonisation With Green Power & Efficiency

Stefan M. Buettner, Josefine Döpp, Liane Strauch, Marina Gilles, Werner König, Anna-Lena Klingler

Subject: Business, Economics And Management, Economics Keywords: decarbonisation; energy supply security; energy demand; energy systems; industry; capacity planning

Online: 28 February 2023 (02:53:02 CET)

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Preprint REVIEW | doi:10.20944/preprints202301.0125.v1

Voltage Lifting Techniques for Non-isolated DC/DC Converters

Abdulaziz Alkhaldi, Ahmad Elkhateb, David Laverty

Subject: Engineering, Electrical And Electronic Engineering Keywords: High voltage gain; DC/DC converter; Step-up techniques; Renewable energy

Online: 6 January 2023 (10:04:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202204.0209.v1

On the Localization of Persistent Currents due to Trapped Magnetic Flux at the Stacking Faults of Graphite at Room Temperature

Regina Ariskina, Markus Stiller, Christian Precker, Winfried Böhlmann, Pablo D. Esquinazi

Subject: Physical Sciences, Condensed Matter Physics Keywords: defect-induced superconductivity; graphite; stacking faults; magnetic force microscopy

Online: 22 April 2022 (03:43:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1258.v1

Magnetic Field Analysis and Thrust Verification of Solenoid Actuator Based on Subdomain Method

Mengkun Lu, Zhifang Yuan, Xianglie Yi

Subject: Engineering, Mechanical Engineering Keywords: Solenoid actuator; subdomain method; magnetic vector potential; push-pull electromagnet; movable iron-core

Online: 18 April 2024 (12:30:39 CEST)

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