The vulcanization of rubber compounds is an exothermal process. A carbon black-filled and natural rubber-based (NR) formulation was mixed with different levels of sulfur (0.5, 1.0, 2.0, 4.0 and 6.0 phr) and studied with Differential Scanning Calorimetry (DSC) for the determination of the vulcanization enthalpy. It was found that the vulcanization enthalpy is dependent from the amount of sulfur present in the compound and the vulcanization heat released was -18.4 kJ/mol S if referred to the entire rubber compound formulation or -46.0 kJ/mol S if the heat released is referred only to the NR present in the compound. The activation energy for the vulcanization of the rubber compounds was also determined by a DSC study at 49 kJ/mol and found quite independent from the sulfur content of the compounds under study. A simplified thermochemical model is proposed to explain the main reactions occurring during the vulcanization. The model correctly predicts that the vulcanization is an exothermal process although it gives an overestimation of the vulcanization enthalpy which is larger for the EV vulcanization package and smaller for the conventional vulcanization system. If the devulcanization is conducted mechanochemically in order to break selectively the sulfur-based crosslinks, then the natural rubber compounds recovered from used tires can be re-vulcanized again and the exothermicity of such process can be measured satisfactorily with DSC analysis. This paper not only proposes a simplified mechanism of vulcanization and devulcanization but also proposes an analytical method to check the devulcanization status of the recycled rubber compound in order to distinguish truly devulcanized rubber from reclaimed rubber.

Mining is an important industry, accounting for 6.9% of global GDP. However, global development promotes accelerated demand, resulting in the accumulation of hazardous waste in land, sea, and air environments. It reached 7 billion tonnes of mine tailings generated yearly worldwide, and 19 billion solid tailings will be accumulated by 2025. Adding to this, the legacy of environmental damage from abandoned mines is worrying; in Canada there are around 10,000 abandoned mines, 50,000 in Australia, 6,000 in South Africa, and 9,500 coal mines in China, reaching 15,000 by 2050. In this scenario, restoration techniques from mining tailing have become increasingly discussed among scholars due to their potential to offer benefits towards reducing tailings levels, thereby reducing environmental pressure for the correct management and adding value to previously discarded waste. This review paper explores available literature on the main techniques of mining tailing recycling and reuse and discusses leading technologies, including the benefits and limitations, as well as emerging prospects. The findings of this review serve as a supporting reference for decision-makers concerning the related sustainability issues associated with mining, mineral processing, and solid waste management.

The bacterial flagellum is a motility organelle, consisting of a long helical filament as a propeller and a rotary motor that drives rapid filament rotation to produce thrust. Salmonella enterica serovar Typhimurium has two genes of flagellin, fljB and fliC, for flagellar filament formation and autonomously switches their expression at a frequency of 10^-3–10^-4 per cell per generation. We report here differences in their structures and motility functions under high viscosity conditions. A Salmonella strain expressing FljB showed a higher motility than the one expressing FliC under high viscousity. To examine the reasons for this motility difference, we carried out structural analyses of the FljB filament by electron cryomicroscopy and found that the structure is nearly identical to that of the FliC filament except for the position and orientation of the outermost domain D3 of flagellin. The density of domain D3 was much lower in FljB than FliC, suggesting that domain D3 of FljB is more flexible and mobile than that of FliC. These differences suggest that domain D3 plays an important role not only in changing antigenicity of the filament but also in optimizing motility function of the filament as a propeller under different conditions.

The purpose of this work is to define optimal growth conditions for batch culture of the cyanobacterium Arthrospira maxima and the microalgae Chlorella vulgaris, Isochrysis galbana and Nannochloropsis gaditana. Thus, we study the effect of three variables on algae growth: i.e., inoculum:culture medium ratio, light:darkness photoperiod and type of culture medium, including both synthetic media and wastewaters. The results showed that the initial inoculum volume did not affect the amount of biomass at the end of the growth (14 days), whereas an excess (18 h) or defect (6 h) in the number of hours of light is determinant for its development. The contribution of nutrients from different culture media modified the growth of the different species. A. maxima was favoured in seawater enriched with Guillard's F/2 as well as C. vulgaris and N. gaditana but in fresh water medium. I. galbana had the greatest growth in the marine environment enriched with Walne’s media. Nitrate was the limiting growth reagent at the end of the exponential phase of growth for C. vulgaris and N. gaditana, while iron was for A. maxima and I. galbana. All species demonstrated their capability to grow in effluents from a wastewater treatment plant and they efficiently consume nitrogen, especially the three microalgae species.

Infant foods and formulae may contain toxic substances and elements which can be neo-formed contaminants or derived from raw materials or processing. The content of minerals, toxic elements and hydroxymethylfurfural in infant foods and formulae were evaluated. The effect of storage temperature on HMF formation in infant formulae and its potential as a quality parameter was also evaluated. Prune-based foods contained the highest HMF content. HMF significantly increased when storage temperature was elevated to 30 ℃ for 21 days. All trace elements were present in adequate amounts while the concentration of nickel was higher when compared to those of other studies. The study indicates that HMF can be used as quality indicator for product shelf-life and that the concentrations of minerals and toxic elements vary greatly due to the diverse compositions of foods and formulae. Such contaminants need to be monitored as infants represent a vulnerable group compared to adults.

Spatial data conflation plays a fundamental role in in many aspects of modern Geographic Information Systems (GIS) research and development such as geospatial data visualization, incremental updating of databases and disaster evaluation. The primary objective of conflation is to derive valuable information based on the comparison of multiple spatial data sources of homogeneous or heterogeneous nature. This paper reviews the state of art of the concept of conflation, feature matching, the most important progresses of conflation between image and road network data, and the complexity of spatial conflation.

Co-integration and Causality was built to conduct studies on causality relation between carbon intensity and coal consumption leading to providing important basis for the transition to a low carbon economy. The EG two-step method was performed to study the relation between carbon intensity and coal consumption of China during 1990-2015 and the co-integration and Granger test was constructed to build up the co-integration and error correction models for analysis of the interaction between carbon intensity and coal consumption. The results showed that in long term there is a stable co-integration relation and a positive correlation between carbon intensity and coal consumption; whereas fluctuations exist in short term and there is a one-way Granger causality of carbon intensity with respect to coal consumption.

Objectives: Recently, desert dust in Europe has been recognized as a cardiovascular health problem. In Spain, desert dust inflows in recent years have been associated with worsening air quality. The present study examines whether desert dust events are related to the incidence of acute coronary syndrome (ACS) in patients under 55 years of age. Methods: Data from 2416 consecutive patients admitted to a tertiary hospital due to ACS were prospectively analyzed. A case-crossover time-stratified design using Poisson conditional regression models was applied to estimate the impact of desert dust events involving particulate matter concentrations of aerodynamic diameter < 10 μm (PM10) on the incidence of ACS. Results: Desert dust intrusion on days 0 to 5 after ACS onset showed no significant association with the incidence of ACS in patients under 55 years of age. The incidence rate ratios of PM10 concentrations 1, 2, 3, 3, 4 and 5 days before ACS onset (for changes of 10 µg/m3) were 1.02 (95% CI 0.97-1.1; p = 0.41), 1.01 (95% CI 0.96-1.07; p = 0.66), 0.99 (95% CI 0.94-1.05; p = 0.78), 0.96 (95% CI 0.9-1.02; p = 0.18) and 0.97 (95% CI 0.91-1.04; p = 0.41). Conclusions: Our findings suggest that desert dust is unlikely to be related to the incidence of premature coronary heart disease.

The present study describes the activities performed to test a new method for measuring the mobility of polycyclic aromatic hydrocarbons (PAHs) in the solid phase of sediments within the context of environmental pollution risk assessment. The method is based on the design of a new configuration (new materials) of the commercial passive sampler Chemcatcher as probe for predicting the bioavailability of persistent organic pollutants in marine sediments (or in water saturated soils).

Background: Poisoning constitutes an important part of morbidity and mortality among environmental emergencies that can be prevented, frequent in childhood, requiring rapid diagnosis and treatment. This study aimed was to examine the epidemiological, clinical and therapeutic characteristics of drug and corrosive poisonings in terms of children. Materials and Methods: Between January 2010 and December 2018, 1678 patients between the ages of 1-16 who applied to the emergency department with drug and corrosive poisoning were included in the study. The patients were divided into three groups as 1-5, 6-11 and over 12 years of age, and the substances with known pharmacological agents were divided into 10 groups. The Zargar Classification (7) was used to determine the degree of damage caused by corrosive substances in the esophagus. Results: The mean age of the patients was 8.32 ± 3.23 years (1-15 years). The girl/boy ratio of the cases was 1.18 / 1 and 54.3% were girls. 18.9% of the cases were under five years of age, 61% were between 6-11 years and 20% were older than 12 years. 94.6% of the patients were poisoned by drugs and 5.4% of them were poisoned due to non-drug reasons. Accidental poisoning was most commonly seen in children aged 6-11 and suicides were seen in children older than 12 years. It was found that 62.2% of the poisonings were accidental and 37.8% were suicidal. The most common causes of poisoning were analgesics and paracetamol exposure as a pharmacological agent. Mortality was found to be most common in 1-5 years age group and accidental poisonings. Accidental poisoning was common in girls and suicidal poisoning was common in boys. Grade 3 damage was found endoscopically in all of the mortalities due to corrosive substances. Conclusion: It was found that accidental poisoning was observed in children under five years of age, suicides were observed in children older than 12 years and the most important cause of mortality was due to corrosive substances. Cause-specific rapid diagnosis and treatment will contribute to the reduction of morbidity and mortality.

The paper presents new data on mineralogical-geochemical peculiarities of the granites and pegmatites of the Baikal area (Olkhon Region) with implications for the age, generation conditions and geodynamic settings of magmatism. The early Paleozoic granitoids of the Olkhon region are syncollisional formations produced from the gneiss-schistose substratum of the Olkhon metamorphic sequences. Pegmatoid granites and pegmatites of the Region were generated within a wide age range (458-390 Ma) and include different mineralogical and geochemical types. Amongst the Early Paleozoic granitoids, pegmatoid rocks are products of the collisional magmatism evolution and are similar to granites in terms of the mineral composition and distribution patterns of rare and rare earth elements. On the Olkhon island (Baikal lake) the pegmatite of the Tashkiney vein belong to the Be-Nb-Ta mineralogical-geochemical type demonstrating high contents of W, Sn U, Th and very low concentrations of Li and volatile components (F, B). In the Pryolkhonye area, vein pegmatite Iliksin is with Li, Be, Nb, Ta mineralization (lepidolite, vorobyevite, samarskite et al). The studied pegmatite veins are similar both by the profound negative Ba, Sr, Eu, and Zr anomalies. The zircons from the Tashkiney vein (390±5.0 Ma) and of the Iliksin vein (430.1±2.2 Ma, U-Pb isotope LA ICP MS metod) indicate the formation of pegmatite at the late post-collisional stage of magmatism in the Olkhon Region. As regard to mineralogical and geochemical characteristics, vein pegmatites with amazonite (Ainsky and Ulan-Nur) belong to the Li-F type. The tantalum mineralization, represented by microlites and minerals of the columbite-tantalite group is associated with the Ainsky amazonite pegmatite. As opposed to the Early Paleozoic syncollisional granitoids and pegmatoid formations, the middle Paleozoic vein bodies of pegmatites (Tashkiney, Iliksin, Ainsky, Ulan-Nur) are regarded as rare-metal pegmatites. In terms of geochemical characteristics, they are similar to the rare-metal pegmatoid granites and pegmatites of the intra-plate setting widespread in Mongolia and Transbaikalia. The rare-metal mineralization in the Olkhon region may be genetically related to the evolution of Be-Nb-Ta and Li-F types of the post-collisional granites and pegmatites.

This paper delves into the comprehensive analysis and investigation of thermodynamic enhancement and exergy optimization of turbofan engines through the integration of fuzzy logic and newest meta-heuristic optimizers, like the Artificial Bee Colony (ABC) and Particle Swarm Optimization (PSO). In contemporary engineering practices, exergy analysis stands out as a crucial and indispensable tool utilized by numerous engineers and researchers in the design, operation, and performance evaluation of energy systems. Its multifaceted advantages include the precise determination of location, types, and quantification of exergy losses and production. By augmenting exergy efficiency while concurrently curbing exergy destruction, substantial enhancements in engine performance and cost reduction can be achieved. The study focuses on the CF6-80A and CFM56 turbofan engines, scrutinizing individual components such as the fan, low-pressure compressor, high-pressure compressor, combustion chamber, high-pressure turbine, and low-pressure turbine. Key parameters for engine evaluation encompass exergy efficiency, recovery potential, relative exergy destruction, fuel depletion rate, and inefficiency. To conduct a rigorous exergy analysis, engine modeling is imperative, particularly during the cruise phase, which predominantly characterizes engine operation. Subsequently, exergy analysis is executed in accordance with established thermodynamic principles, leveraging equations governing mass conservation, energy conservation, and exergy conservation for each engine component. Further optimization of exergy destruction is achieved through the application of meta-heuristic optimizers and fuzzy logic, facilitating informed decision-making processes.

Diarrhea and fever are prevalent childhood illnesses with potentially severe consequences, especially when they co-occur. This study investigates the prevalence and determinants of diarrhea, fever, and their coexistence among children under-five in Bangladesh. Data from the 2017-18 Bangladesh Demography and Health Survey (BDHS) were analyzed using multivariable stepwise logistic regression with backward selection. This study found that 5.0% for diarrhea, 34.0% for fever, and 3.0% for the coexistence of both illnesses. Common factors associated with childhood diarrhea and fever included the mother's education, her attitude toward wife-beating, and the child’s age (12-23 months). Diarrhea was associated with households with improved water sources and children in the Barisal division, while fever was linked to underweight children and those from more affluent backgrounds. The coexistence of both was significantly linked to underweight children, higher birth orders, and children from the Rajshahi division. Notably, child illnesses were associated with parental education, higher socio-economic status, and access to improved drinking water sources. Diarrhea affects one in 20 children, fever affects one in three, and the coexistence of both conditions affects one in 35 children in Bangladesh. The findings need further research and policy reviews to develop effective interventions and improve child health in Bangladesh.

The functional capacity of the cervical spine plays a central role in healthy living. This study evaluated and created a comprehensive strength, range of motion (ROM), and musculoskeletal pain profile of the cervical spine in young adults. 60 physically active individuals (30 males/30 females; 19-24 year-old) participated in the study. Cervical ROM (forward flexion, extension, lateral flexion, and rotation), maximal isometric strength (forward flexion, extension, lateral flexion), and musculoskeletal pains were assessed using an electronic goniometer, a handheld dynamometer, and the Nordic questionnaire, respectively. Data analysis revealed that: a) fe-males had higher ROM values, during extension and lateral flexion, than males (p<0.05), b) males had higher absolute strength values than females in all movement directions, higher rela-tive strength values/body mass (at forward flexion) and flexion/extension ratio values (p<0.05), c) ROM and strength values were not significantly different between right-left sides (p>0.05), d) a great proportion (43.3%) of the participants had cervical pains (no sex-related differences) and e) cervical strength showed significant small negative correlation with pains (p<0.05; r=-0.225 to -0.345). The reference values created may be used by health and fitness professionals to exten-sively evaluate the cervical spine and to design specific exercise programs for injury prevention and rehabilitation.

This article is a commentary on the publication Guo J, Hai H, Ma Y. Application of extracorporeal shock wave therapy in nervous system diseases: A review. Front Neurol. (2022) 13:963849. doi: 10.3389/fneur.2022.963849 (1). In the opinion of the authors of this commentary the information provided in the Section "Principles of ESWT" in (1) is partly incorrect and misleading. This is due to the fact that important, published knowledge regarding focused extracorporeal shock wave therapy (fESWT) and radial extracorporeal shock wave therapy (rESWT) was disregarded in (1).

Abstract: Background: The practice of menstrual hygiene(MH) is a public health issue and depends on various factors. Taboos and incorrect MH practices can lead to health hazards. This study aimed at assessing the Knowledge, Attitude, and Practice of MH among the female students and faculty of Medical and Health Sciences University. Materials and methods: This cross-sectional questionnaire survey between February and June 2023 using consecutive sampling. Univariate analysis and comparisons were done with a significant p-value <.05. Results: A total of 253 women participated in the study. The knowledge and practices of MH were good. There were significantly more irregular and painful periods in younger females (p=.005,.0001). 89% of women used disposable pads and least used menstrual cups. Younger women were unaware of menstrual cloth. The attitude towards menses varied, with younger females feeling annoyed (p=.002), and older females embarrassed (p=.0001) at menarche. About 1/3rd of participants perceived menstrual blood as unhygienic. Younger women were more open about talking about menses (p=.005). Conclusion: There was good knowledge and practices of MH among participants. There were differences in menstrual history and attitude among older and younger women. The attitude and beliefs vary among the participants, due to sociocultural factors and age differences.

This study was to determine the effects of different irrigation, fertigation and mulching applications on the yield and quality parameters of strawberries. The study was conducted at the Bursa Uludağ University Yenişehir Ibrahim Orhan Vocational School Agricultural Research Field in 2019-2020. In the research, four different irrigation topics, three different fertigation and three different mulching topics were selected The maximum and minimum yield values of the study years were calculated as 5.05-18.70 t ha-1 and 1.20-8.7 t ha-1, respectively, from I100F100M1 and I25F50M0 treatments. As a result, a three-factor study determined that irrigation, fertigation, and mulching had a significant effect on the yield and quality characteristics of strawberries. However, when the reductions in yield and quality losses are evaluated together, despite the reductions in irrigation water and fertigation levels, I75 and F75 topics can be recommended. Also, in mulching treatments, black mulch material (M1) should be chosen over clear mulch material (M1) and no mulch (M0).

Silver in different forms is used for medical purposes from ancient times. It is not yet well known, which form of silver is more biocompatible and less toxic. Here we considered silver nanoparticles and silver citrate. Also, the relationships of neurotoxicity of silver compaunds with ageing factor is not yet described. To assess the role of nanoform in neurotoxicity of silver and role of ageing a long-term experiment was conducted. We had four control groups of intact mice and four experimental groups which were exposed to silver nanoparticles and silver citrate for two months. Four groups of mice were introduced into the experiment since the age of five months to assess ageing factors. It was shown that the nanoform does play a certain role in neurotoxicity of silver. Silver citrate seems to be a more preferable silver compound. Ageing can be regarded as a positive factor that neutralizes toxic action of silver compounds. It may be due to the development of physiological/cognitive functions with the age as well as adaptation to unnatural content in the individual cages that is definitely stressful for mice.

To date, most people prefer softer and stickier rice with high glycaemic index, which has led to the study of the association between the dietary fibre profile and the textural properties to balance between the eating quality, and health benefits. A slight variation was observed in the dietary fibre composition among rice varieties with different amylose content. The percentage of insoluble dietary fibre (IDF) in whole grain rice varied from 1.65–4.32 while the percentage of soluble dietary fibre (SDF) ranged from 0.26–1.37. We demonstrated that the SDF/IDF ratio was higher in soft texture rice with low amylose and it shared a negative correlation with hardness and chewiness of cooked whole grain rice determined by a texture analyser, which suggested that the distribution of SDF throughout the rice endosperm influences the reduction of the hardness of cooked rice. According to the importance of dietary fibre, we proposed a simple linear regression method to estimate the amount of IDF and total dietary fibre with r = 0.97 and 0.92, respectively, of whole grain rice based on its bran layer, determined by the alternative alkaline method. Furthermore, low amylose rice has higher content of -glucan and pectin, which are classified as soluble dietary fibre, than high amylose rice. The percentage of -glucan and pectin in whole grain rice ranged from 0.03 and 0.07 respectively, for high amylose rice to 0.14 and 0.27 respectively for low amylose rice,

This paper aims to establish a current relationship between pharmaceutical sciences and the development of perfumes and fragrances, which bring significant economic benefits and whose added value is among other professionals, the one made by professionals in Pharmacy. For this purpose, historical data are used as a starting point and galenic, chemical and botanical aspects are discussed in a transversal way. In this sense, it must be taken into account that in the case of Spanish pharmacy, it is closely linked to the knowledge and use of plants. Sources such as Web of Science (WOS) and databases such as Scopus, monographs and various web pages (where scientific-technical documents appear) have been used. The results and discussion are based on the selection of the 50 plant species most commonly used in high quality fragrances. Therefore, this publication should be considered as an approach to this subject based on an analysis of a representative sample of data. Some characteristics of perfumes (classification according to the concentration of essential oils and combination of plant extracts) are presented beforehand. They also briefly compile the traditional and modern ways in the treatment of these extracts. The main focus of this work is the botanical and chemical analysis of these described plants, pointing out their common name, correct botanical name, geographical place of origin, used part of the plant and main molecules. The 50 botanical species belong to 27 families of angiosperms and are represented in a large part of the phylogenetic tree of botanical systematics. The most significant families are aromatic: Rutaceae (16.7%), Lamiaceae (16.7%) and Apiaceae (6.5%). The most represented genus is Citrus (with seven species or hybrids). However, it should be noted that natural extracts of good quality natural fragrances may be supplemented with chemically synthesized molecules. Of the 50 botanical species selected, 84% of the extracts have their origin in Tropical Asia, the Middle East and the Mediterranean region. This figure generally coincides with the percentage of medicinal plants (or their extracts) admitted by the European Pharmacopoeia. All parts of a plant (depending on which one it is) can be a source of molecules for the elaboration of these products. The most commonly used parts to obtain extracts are flowers (34%) and leaves (30%), a biological circumstance that is explained in this work. On the opposite side are the resins (10%), rhizomes and roots (8%). In this work, 110 molecules have been found that are part of the essences of perfumes and fragrances, the most frequent are: linalool, limonene, 1,8-cineole, eugenol and derivatives, geraniol, vanillin and derivatives, β-cariophyllene, p-cmene and farnesene and derivatives (3.64%). However, in order to elaborate a quality perfume, many other molecules must be taken into account, according to the creative experience of the perfumer, which is subject to confidentiality and chemical analysis according to current legislation, which would avoid fraud, allergy and dermatitis problems.

Trigonella foenum is one of the oldest medicinal plants that grow in many parts of Iran with the diverse ecological situation. Employing this plant for treating diabetes and high cholesterol has a long history, because of some metabolites. Due to the habitat of fenugreek is a wide range of climatic conditions, it may have power to cope with climate variation. The main intention of this inquiry was to understand the effect of the environmental variables on this therapeutic plant features. It was also interesting for us to understand which environment variables are more impressive for enhancing of trigonelline and 4-hydroxy isoleucine content as the most important metabolites of this plant. For achieving this goal, environmental information and vegetal data were analyzed to discover the role of nature on the seed part of fenugreek life in 50 different regions of Iran. Canonical correspondence analysis (CCA) displayed that high content of metabolites and some morphological characteristics happened in high temperature and solar irradiation. Partial least squares regression (PLSR) and path analysis used to find the best predictors and direct and indirect effect of all variables on 4-hydroxy isoleucine and trigonelline. Ecological condition were the best predictors and had the highest direct and indirect impact on 4-hydroxy isoleucine. However, for trigonelline, the environment did not play a senior role. It seems that the reaction of components of fenugreek does not follow the same way. Studying on morphological, primary and secondary metabolites, and surrounding environment of fenugreek, helped us to have a more precise judgment about the life of this plant.

This work considers the existence of heteroclinic solutions for second order differential equations with ϕ-Laplacians and generalized impulsive conditions on the real line. For the construction of the results, it was only imposed that ϕ is a homeomorphism and the Schauder’s fixed point theorem allied with the concepts of L1-Carathéodory functions and sequences together with the equiconvergence on infinity and on each impulsive moments. Finally, a practical part illustrates the main theorem.

Healthcare leaders are faced with many financial challenges in the contemporary environment, leading to many bankruptcies in recent years. What is not well understood are the specific conditions that lead to organizational economic failure. Ideally, hospital leaders could examine the literature for guidance to predict bankruptcy before it occurs. However, existing regression methods have proven inadequate, especially when the finance variables follow a nonnormal frequency pattern. Furthermore, the regression approach encounters difficulties due to multicollinearity and nonnormality issues. Therefore, an alternate stochastic approach for predicting the probability of hospital bankruptcy is warranted. This new method includes computing and interpreting the correlations between the hospital’s revenue and expenses for bivariate lognormal data, calculating the risk of bankruptcy due to the mismatch between revenues and expenses, determining the likelihood of a hospital’s expense exceeding the state’s median expense level, and evaluating a hospital’s financial memory level. Ultimately in our research, we demonstrate a novel approach to anticipate hospital bankruptcy, which can be particularly useful for health policy analysts and hospital leaders in making informed financial decisions and proactively managing risks to ensure the sustainability and stability of their institutions.

Reducing the immunogenicity of animal-derived monoclonal antibodies (mAbs) for use in humans is critical to maximize therapeutic effectiveness and preclude potential adverse events. While traditional humanization methods have primarily focused on grafting antibody Complementarity-Determining Regions (CDRs) on homologous human antibody scaffolds, framework regions can also play essential roles in antigen binding. Here, we describe the humanization of the pan-HLA-DR mAb 44H10, a murine antibody displaying significant involvement of the framework region in antigen binding. Using a structure-guided approach, we identify and restore framework residues that directly interact with the antigen or indirectly modulate antigen binding by shaping the antibody paratope and engineer a humanized antibody with affinity, biophysical profile, and molecular binding basis comparable to that of the parental 44H10 mAb. As a humanized molecule, this antibody holds promise as a scaffold for the development of MHC class II-targeting therapeutics and vaccines.

Abstract Background: Hypochlorous acid (HA) is a potent disinfectant with broad-spectrum antimicrobial activity against bacteria, fungi, and viruses. Aim: This study aimed to investigate the factors that influence the stability of hypochlorous acid (HOCl) and their impact on its disinfectant properties Methods: This study explored the stability of hypochlorous acid, emphasizing factors that affect its disinfectant efficiency, such as pH level, temperature, and the presence of organic materials. Findings: Our investigation revealed that HOCl is the most stable and effective disinfectant under weakly acidic conditions, where the undissociated form of hypochlorous acid is predominant. Although it is stable under various conditions, its efficacy is compromised by the presence of heavy metals, organic matter, and UV radiation. Conclusions: This comprehensive analysis concludes that, while hypochlorous acid is a highly effective disinfectant, understanding and maintaining the optimal conditions for its stability is crucial for maximizing its disinfection potential. Implications: The findings can be used to formulate new guidelines and regulations to guide the proper formulation, storage, and use of stable HOCL as disinfectants.

Sub-micro dislocation cellular structures formed during rapid solidification break the strength-ductility trade-off in laser powder bed fusion (LPBF)-processed 316L stainless steel through high-density dislocations and segregated elements or precipitates at the cellular boundaries. The high-density dislocation entangled at the cellular boundary accommodates solidification strains among the cellular structures and cooling stresses through elastoplastic deformation. Columnar grains with cellular structures typically form along the direction of thermal flux. However, the ultra-low misorientations between the adjacent cellular structures and their interactions with the cellular boundary formation remain unclear. In this study, we revealed the ultra-low misorientations between the cellular structures in LPBF-processed 316L stainless steel using conventional electron backscatter diffraction (EBSD), transmission Kikuchi diffraction (TKD), and transmission electron microscopy (TEM). The conventional EBSD and TKD analysis results could provide the misorientation angles smaller than 2° while the resolution mainly depends on the specimen quality and scanning step size, and so on. TEM technique with higher spatial resolution provides accurate information between adjacent dislocation cells with misorientation angles smaller than 1°. This study presents that TEM method is the better and more precise analysis method of the misorientation measurement of the cellular structures and provides insights into measuring the small misorientation angles between adjacent dislocation cells and nanograins in nanostructured-metals and alloys with ultrafine-grained microstructures.

Background: Immersive and non-immersive VR technology has been increasingly employed in training. This has encouraged physicians working in skill development to try using it to improve the learning, emotional recognition, and social skills of various disorders. This study aimed to explore the controlled trials employing VR in autism, ADHD, and dyslexia. Methodology:A literature review has been conducted, on PubMed, Scopus, and Web of Science. Any controlled trial in the pediatric age group, involving the comparison of VR training with other types of therapies in autism, ADHD, and dyslexia was included. Results:Only four controlled trials were identified, comprising a total of 208 patients, with ages ranging from 6-16 years. Out of these studies, two involved patients with autism, one with ADHD, and one with dyslexia. VR was successful in improving emotional recognition but not social interaction in autism. All trials did not mention thoroughly possible complications of prolonged use of VR. Conclusion: Despite being a promising technology, there is still a long road to prove the validity of using VR in skills development. Few controlled trials have been tailored to explore VR advantages over conventional training and therapies, most of them have a limited sample size, a short training course, and no mention of possible setbacks, such as ocular effects and social isolation.

Historical and Endowment Properties are different from Heritage and cultural Properties, as Historical and Endowment properties are governed by a unique set of laws that Waqf recipients must abide by. Property that is entrusted is usually in the form of buildings, land or valuables which in preservation is not limited to time as long as the property can be utilized. Reliable information technology is needed to ensure data security both digitally and physically, while the rapid development of information technology demands information openness and this will be a challenge in itself. The objectives of this study include examining the collection of historical databases and endowments, the relationship between digital data and physical data and management organizations. The method of how to design a query model to display data is then analyzed whether the data conforms to the rules in waqf management. The results are expected to bring up accurate data between digital data and physical data and if there are differences into findings for the next analysis.

This study compared the mineral content and bioactive properties of flowers and fruit coming from wild elderberry plants with those of flowers and fruit harvested from elderberry cultivars grown in an orchard. Elderberry fruit and flowers were analysed for the content of selected minerals, phenolic compounds and anthocyanins and for antioxidant activity. Mineral content was determined by atomic absorption spectrometry method, while antioxidant activity and the content of polyphenols and anthocyanins were determined by spectrophotometric methods. Flowers were found to contain more total ash and to have much higher content of most of minerals, except magnesium, which was present in high concentrations in fruit. Fruit showed significantly higher antioxidant activity than flowers, whereas the total phenolic content varied depending on the growing location / cultivar. The material obtained from selected cultivars growing in an orchard had higher antioxidant activity and polyphenol and anthocyanin content than the material obtained from wild plants. Fruit of the ‘Haschberg’ cultivar and flowers of the ‘Sampo’ cultivar had the best bioactive properties of the studied samples.

This paper contextualises the common queries of "why is crypto crashing?" and "why is crypto down?", the research transcends beyond the frequent market fluctuations to unravel how cryptocurrencies fundamentally work and the step-by-step process on how to create a cryptocurrency. The study examines blockchain technologies and their pivotal role in the evolving Metaverse, shedding light on topics such as how to invest in cryptocurrency, the mechanics behind crypto mining, and strategies to effectively buy and trade cryptocurrencies. Through an interdisciplinary approach, the research transitions from the fundamental principles of fintech investment strategies to the overarching implications of blockchain within the Metaverse. Alongside exploring machine learning potentials in financial sectors and risk assessment methodologies, the study critically assesses whether developed or developing nations are poised to reap greater benefits from these technologies. Moreover, it probes into both enduring and dubious crypto projects, drawing a distinct line between genuine blockchain applications and Ponzi-like schemes. The conclusion resolutely affirms the continuing dominance of blockchain technologies, underlined by a profound exploration of their intrinsic value and a reflective commentary by the author on the potential risks confronting individual investors.

Previous work has shown that perturbation analysis in algorithmic information dynamics can uncover generative causal processes of finite objects and quantify each of its element's information contribution to computably constructing the objects. One of the challenges for defining emergence is that the dependency on the observer's previous knowledge may cause a phenomenon to present itself as emergent for one observer at the same time that reducible for another observer. Thus, in order to quantify emergence of algorithmic information in computable generative processes, perturbation analyses may inherit such a problem of the dependency on the observer's previous formal knowledge. In this sense, by formalizing the act of observing as mutual perturbations, the emergence of algorithmic information becomes invariant, minimal, and robust to information costs and distortions, while it indeed depends on the observer. Then, we demonstrate that the unbounded increase of emergent algorithmic information implies asymptotically observer-independent emergence, which eventually overcomes any formal theory that any observer might devise. In addition, we discuss weak and strong emergence and analyze the concepts of observer-dependent emergence and asymptotically observer-independent emergence found in previous definitions and models in the literature of deterministic dynamical and computable systems.

The main objective of this study was to study the effect of occupational stress on turnover intentions, as well as whether this relationship is mediated by burnout levels and moderated by motivation. The sample of this study consisted of 603 participants, all employees of the Portuguese Tax and Customs Authority, which is part of the Ministry of Finance and belongs to the Direct State Administration. The results indicate that occupational stress (with managers, with career and remuneration and with work overload) has a positive and significant effect on turnover intentions and that this relationship is mediated by burnout. Motivation (intrinsic and identified) has a negative and significant effect on turnover intentions. Intrinsic motivation moderates the rela-tionship between occupational stress (with managers, with colleagues, with career and pay and with family problems) and turnover intentions. These results indicate that among the dimensions of occupational stress, the most critical are stress with managers, work overload and career and pay. These are factors that the Direct State Administration should be concerned about in trying to minimize their causes.

This paper gives both a general canonical quantum gravity theory and the general canonical quantum gravity theories of the Universe and general black hole, and discovers the relations reflecting symmetric properties of the standard nonlinear gravitational Lagrangian, which are not relevant to any concrete metric models. This paper concretely shows the general commutation relations of the general gravitational field operators and their zeroth, first, second and third style, respectively, of high order canonical momentum operators for the general nonlinear system of the standard gravitational Lagrangian, and then has finished all the four styles of the canonical quantization of the standard gravity.

The sustainability of grazing lands lies in the nexus of human consumption behavior, livestock productivity, and environmental sustainability. Due to fast growing global food demands, many grazing lands have suffered from overgrazing, leading to soil degradation, air and water pollution, and biodiversity losses. Multidisciplinary efforts are required to understand how grazing lands can be better monitored, assessed and managed to attain predictable outcomes of optimal benefit to society. This paper synthesizes our understanding based on previous work done on impacts of grazing on ecosystem goods and services, identifies current knowledge gaps, and formulates a plan forward. We review the impacts of two contrasting grazing systems, continuous and multi-paddock rotational grazing, on soil carbon (C), nutrient cycling and greenhouse gas emissions (GHGs). We then extend our review to explore challenges of incorporating spatial heterogeneity and temporal variability into monitoring and modelling C and nutrient cycling in grazing lands. We revisit two process-based models (i.e., DNDC and DayCent) and two watershed models (i.e., SWAT and VIC) widely used to simulate C, nutrient and water cycles of these lands. Finally we identify research directions for improving the knowledge base which is essential to conserve grazing lands and maintain their ecosystem goods and services.

Dryland winter wheat in Loess Plateau is facing yield reduction due to shortage of soil moisture and delayed sowing time. Field experiment was conducted at Loess Plateau in Shanxi Province, China from 2012 to 2014, to study the effect of subsoiling and conventional tillage and different sowing dates on the soil water storage and contribution of N accumulation and remobilization to yield of winter wheat. The results showed that subsoiling significantly improved the soil water storage at 0-300 cm depth, improved the number of tillers and pre-anthesis N translocation in various organs of wheat and post-anthesis N accumulation, eventually increased the yield up to 17-36%. Delaying sowing time had reduced the soil water storage at sowing and winter accumulated temperature by about 180˚C. The contribution of N translocation to grain yield was maximum in glume+spike followed by in leaves and minimum by stem+sheath. In addition a close relationship was found between the N accumulation and translocation and the soil moisture in the 20-300 cm. Subsoiling during the fallow period and the medium sowing date was beneficial for improving the soil water storage and increased the N translocation to grain, thereby increasing the yield of wheat, especially in dry year.

Porcine reproductive and respiratory syndrome virus (PRRSV) infections cause significant economic losses to swine producers every year. Aerosols containing infectious PRRSV are an important route of transmission, and proper treatment of air could mitigate the airborne spread of the virus within and between barns. Previous bioaerosol studies focused on the microbiology of PRRSV aerosols; thus, the current study addressed the engineering aspects of virus aerosolization and collection. Specific objectives were to (1) build and test a virus aerosolization system, (2) achieve a uniform and repeatable aerosol generation and collection throughout all replicates, (3) identify and minimize sources of variation, (4) verify that the collection system (impingers) performed similarly. The system for virus aerosolization was built and tested (Obj. 1). The uniform airflow distribution was confirmed using a physical tracer (<12% relative standard deviation) for all treatments and sound engineering control of flow rates (Obj. 2). Theoretical uncertainty analyses and mass balance calculations showed <3% loss of air mass flow rate between the inlet and outlet (Obj. 3). A comparison of TCID₅₀ values among impinger fluids showed no statistical difference between any two of the three trials (p-value = 0.148, 0.357, 0.846) (Obj. 4). These results showed that the readiness of the system for research on virus aerosolization and treatment (e.g., by ultraviolet light), as well as its potential use for research on other types of airborne pathogens and their mitigation on a laboratory scale.

Systemic AL amyloidosis is a challenging disease for which many patients are considered frail in daily clinical practice. However, no study has so far addressed frailty and its impact on the outcome of these patients. We built a simple score to predict mortality based on three frailty-associated variables: age, ECOG performance status (&lt;2 vs. 2) and NT-proBNP (&lt;8500 vs. 8500 ng/L). Four-hundred and sixteen consecutive newly diagnosed patients diagnosed at ten sites from the Spanish Myeloma Group were eligible for the study. The score was developed in a derivation cohort from a referral center, and it was externally validated in a multicenter cohort. On multivariate analysis the three variables were independent predictors of survival. The score was able to discriminate four groups of patients in terms of overall survival and early mortality in both cohorts. Comorbidity was also analyzed with the Charlson comorbidity index, but it did not reach statistical significance in the model. A nomogram was created to easily estimate the mortality risk of each patient at each time point. This score is a simple, robust, and efficient approach to dynamically assess frailty-dependent mortality both at diagnosis and throughout the follow-up. The optimal treatment for frail AL amyloidosis patients remains to be determined but we suggest that the estimation of frailty-associated risk could complement current staging systems, adding value in clinical decision-making in this complex scenario.

Litchi (Litchi chinensis Sonn.) is considered as one of the most important sub-tropical fruits of the World. Under western part of Odisha, India, the litchi growers are facing problem of unstable and lower marketable yield and inferior quality due to higher incidence of fruit cracking, fruit drop, low sugar content and higher fruit acidity. Keeping in mind the positive effects of nutrients and bioregulators, the current study was conducted to elucidate their impact on fruit yield, and quality in the farmers field of Jamankira block in Sambalpur district of Odisha under Odisha University of Agriculture and Technology, India. For the studies, eight years old litchi trees were selected. With 12 treatments, the experiment was set up in a randomized block design replicated thrice viz, T₁: Spray treatment of Borax @ 0.5%; T₂: Spray treatment of Borax @ 0.3%; T₃: Spray treatment of ZnSO₄ @ 0.75% ; T₄: Spray treatment of ZnSO₄ @ 0.5%; T₅: Spray treatment of CaCl₂ @ 0.5%; T₆: Spray treatment of CaCl₂ @ 0.1%; T₇: Spray treatment of Humic acid @ 1.5%; T₈: Spray treatment of Humic acid @ 1%; T₉: Spray treatment of Seaweed extract @ 0.5%; T₁₀: Spray treatment of Seaweed extract @ 0.1 %; T₁₁: Foliar spray of NAA @ 20 ppm and T₁₂ : Control (water spray).The current study compared foliar feeding of different nutrient and bioregulators treatments, which were applied during the first week of December, just after completion of new leaf formation and untreated control. The total number of fruits per plant was recorded highest in plants sprayed with ZnSO4 @ 0.5% (T₄) followed by those treated with humic acid @ 1% (T₈). The highest total fruit yield was recorded in plants with foliar feeding of 0.3% Borax (T₂) which was found to be statistically similar to plants treated with seaweed extract @ 0.1% (T₁₀)and seaweed extract @ 0.5% (T₉).Among the treatments better response for higher number of marketable fruits and marketable yield was recorded in plants treated with both 0.3% Borax (T₂) followed by 0.5% Zinc sulphate (T₄), 1% Humic acid (T₈) and 0.1% CaCl₂ (T₆) in litchi. Application of 1% Humic acid (T₈) followed by 1.5% Humic acid (T₉) enhanced the fruit set (%) and fruit retention (%) along with reduction in fruit drop (%). The enhanced fruit size (fruit length and fruit breadth) and higher fruit weight was obtained in plants treated with 0.3% Borax in litchi. The foliar application of 0.3% Borax (T₂) had also resulted in higher TSS, total sugars, reducing sugar, lower acidity, highest aril weight and lower seed weight in litchi cv. Bombai.

Background: Caring for individuals with mental disorders poses significant challenges for caregivers, often leading to compromised quality of life and mental health issues such as stress, anxiety, and depression. This study aims to assess the extent of these challenges among caregivers in Greece, identifying which demographic factors influence their well-being. Method: A total of 157 caregivers were surveyed using the SF-12 Health Survey for quality of life assessment and the DASS-21 questionnaire for evaluating stress, anxiety, and depression symptoms. T-tests, Kruskal-Wallis tests, Pearson correlation coefficients, and regression analyses were applied to understand the associations between demographics, quality of life, and mental health outcomes. Results: The study found that caregivers, especially women and younger individuals, faced high levels of mental health challenges. Marital status, educational level, and employment status also significantly influenced caregivers' well-being. Depression was the most significant factor negatively correlating with the mental component of quality of life. The magnitude of burden experienced by caregivers highlighted the urgency for targeted social and financial support, as well as strategic treatment programs that consider caregiver well-being. Conclusions: Caregivers of individuals with mental disorders endure significant stress, anxiety, and depression, influencing their quality of life. Demographic factors such as age, gender, marital status, education, and employment status have notable impacts. Findings emphasize the need for society-wide recognition of caregivers' roles and the creation of comprehensive support and intervention programs to alleviate their burden, particularly in the context of the COVID-19 pandemic.

Cardiovascular and cerebrovascular disease incidence has risen mainly due to poor control of preventable risk factors and still constitutes a significant financial and health burden worldwide. ChatGPT is an artificial intelligence language-based model developed by OpenAI. Due to the model’s unique cognitive capabilities beyond data processing and the production of high-quality text, there has been a surge of research interest concerning its role in the scientific community and contemporary clinical practice. To fully exploit ChatGPT's potential benefits and reduce its possi-ble misuse, extreme caution must be taken to ensure its implications ethically and equitably. In this article, we explore the language model's possible applications and limitations while empha-sizing its potential value for diagnosing, managing, and prognosis cardiovascular and cerebro-vascular disease.

Quality of life (QOL) is based on their perception of their position in life in respect to their goals, expectations, standards, and concerns, as well as their culture and value systems, their workflow and workplace situations while it influences quality of services. In this study we aim to report on dental and nursing academians’ QOL and well-being at the end of the third year of the COVID-19 pandemic. The World Health Organization Quality of Life-BREF Scale (WHOQOL-BREF) tool, recording Physical, Psychological, Social and Environmental dimensions of QOL, was used. The WHOQOL-BREF was modified on a spiritual, coaching/mentoring approach in a two-step designing and validated procedure. The modified SHQOL-BREF (Spiritual Healthcare version) designed for this study, was uploaded, and filled in online during April-June 2023. Staff (N=120, 75% female) of both departments of Dentistry (44.2%) and Nursing (55.8%) of the National and Kapodistrian university of Athens, participated in anonymity. QOL in terms of physical health was reported at a higher level (M=72.2 points) compared to social relationships (M=69 points), psychological health (M=65 points) and environment (M=59 points) (scores reported in 0-100 score). Overall QOL was rated at 66 points while satisfaction from health at 72 points. Job satisfaction (M1=3.2) and spirituality (M2=3.0) were reported at a medium level in a 5-point scale, while personal beliefs and values were reported at a high level (M3=4.0). Participants age presented a significant, moderate to strong effect on physical health [F(3,97)=2.89, p&lt;.05, η2p=.08] and on environment [F(3,97)=2.80, p&lt;.05, η2p=.08] and marital status on social relationships [F(1,97)=9.66, p&lt;.05, η2p=.09]. Married participants reported consistently higher levels of QOL compared to single participants, for all age groups. Department had a significant moderate effect on social relationships (F(1,97)=5.10, p&lt;.05, η2p=.05) and education a significant moderate to strong effect on psychological health (F(2,97)=3.74, p&lt;.05, η2p=.07). PhD level participants in both departments presented higher levels of psychological health compared to lower educational levels. Also, participants from the department of Dentistry reported higher levels of social relationships QOL in all educational groups, compared to the department of Nursing. Strategic planning on sustainability and QOL initiatives should be introduced after the COVID-19 pandemic for dental and nursing academic personnel to promote resilience and QOL scores.

This article presents a harmonic analysis of the stator currents of a squirrel-cage in-15 duction motor fed by a voltage source inverter with PWM space vector control (SV-PWM). The 16 influence of PWM switching frequency and dead time (dead-band) of controlled transistors on 17 THD and electromagnetic torque ripple is shown. The aim is to determine the lowest switching 18 frequency of the transistors for which the drive will operate correctly. Characteristics were de-19 termined as functions in the form of THD ( ), where the least square approximation was 20 used for stator current measurements when the PWM switching frequency is changed. The ap-21 proximations were realized for simulation and experimental results. To clarify the results, the 22 operation of hardware PWM circuits in microcontrollers was analyzed.

Abstract: The aim of this study was to identify and quantify polyphenolic compounds in skin extracts from four Bulgarian grape varieties and compare to those of seed extracts. The values of total phenolic contents (TPC), flavonoids, anthocyanins, procyanidins, ascorbic acid in grape skin extracts were determined. The antioxidant capacities of skin extracts were evaluated by DPPH, ABTS, FRAP and CUPRAC methods. The TPC values of skin extracts were 2-3 times lower than those of seed extracts. The significant difference between total parameters values of individual grape varieties were also found. According to the TPC and antioxidant capacity of skin extracts the different grape varieties were in the following order: Marselan ≥ Pinot Noir ˃ Cabernet Sauvignon ˃ Tamyanka. The individual compounds in the grape skin extracts were determined by RP-HPLC and compared with those of seed extracts. The determined composition of skin extracts was significant different from seed extracts composition. Qualitative and quantitative evaluation of the procyanidins and catechins in the skins were carried out. A correlation between phenolic contents, individual composition and antioxidant capacity of different extracts was found. The studied grape extracts have a potential to be applied as natural antioxidants in the pharmaceutical and food industries.

China promotes nature-based solutions (NbS) as key approaches to addressing climate change, ecosystem damage, and biodiversity loss. However, indigenous and local knowledge (ILK), which is recognized by international scholars as an essential element of successful NbS, has not been thoroughly studied in the Chinese context. By conducting a comprehensive review of Chinese central governmental policies and semi-structured interviews with typical cases, this study finds out diversified sources of ILK and five pathways of ILK integration, including education, supervision, participation, knowledge preservation, and knowledge adoption. An increasing emphasis on community engagement has been driven by central policies such as the ecological civilization, carbon peaking and carbon neutrality goals. From a practical perspective, consistent core ideas of ILK exist in selected typical Chinese cases and studies in other countries, namely co-existence and reciprocity with nature. While supportive central policies can set the scene, ILK integration could not be realized without local governmental endorsement, context-based implementation, and long-term multi-stakeholder participation. Furthermore, this study also figures out a potential deficiency in terms of realizing effective ILK integration in mainstream and conventional practices, which can be further investigated by future studies.

Erosion caused by the repeated impact of particles on a substance surface is a usual wear method resulting in gradual and continual loss of objects. It is a crucial problem in several modern industries because their surfaces are frequently subjected to destructive erosive situations. Polymers and their hybrid materials include several applications to be used as a coating in the form of powder for different applications. This review paper aims to provide extensive information on the erosion behavior of thermoset and thermoplastic neat resin and their hybrid materials composites. Focus is specifically paid to highlight the influence of properties of selected materials, impingnation parameters such as incident Angle of erodent, impact velocity of erodent, erodent nature, and the erosion mechanism. The review further extends the information about the erosion techniques and numerical simulation methods used for wear studies of surfaces. An investigation has been carried out for researchers to explore the selection of materials and methods in terms of conditions and parameters to meet the current and future needs and challenges for the protection of surfaces of the advanced industries. During review according to the findings achieved from the literature of the past fifty years, it has been noted that the thermoplastic nature of the composite is a key component to determine the anti-wear properties, the composites with lower glass transition, higher ductility, and greater crystallinity can provide better protection to erosion in advance surface applications.

In 1922, Albert Einstein visited Paris and interacted extensively with an illustrious section of the French academia. In overfilled sessions at the Coll\`{e}ge de France and the Sorbonne, Einstein explained his theories of relativity, and prominent physicists, mathematicians and philosophers listened, debated, questioned and explored facets of relativity. The 1922 visit had its echoes in the life and works of many who participated, particularly decisive for Einstein and the philosopher Henri Bergson. This essay examines that eventful visit, focusing on the physical and logical aspects of Bergson's critique, with physics commentaries, linking prominent French physicists and mathematicians Langevin, Painlev\'{e}, Hadamard, Becquerel, Sagnac, and Kastler. I give particular attention to the logical and empirical accuracy of the physics issues involved, delineating Bergson's exact reasoning for his philosophical enthusiasm in Einstein's theory and for the ensuing critique. Bergson's philosophical stand on duration and simultaneity is reassessed in the context of later developments in cosmological physics as well as the wealth of empirical data involving comparison of atomic clocks. Finally we are led naturally to a surprising completion of the philosopher's program on universal time, duration and simultaneity, in harmony with the time of the physicist. In the appendices after the main text I also give the physics background and easily verifiable proofs for the assertions made in the text, pertaining to relativity, simultaneity and time dilation, clearly distinguishing beliefs and facts.

To build a representation of what we see, the human brain recruits regions throughout the visual cortex in cascading sequence. Recently, an approach was proposed to evaluate the dynamics of visual perception in high spatiotemporal resolution at the scale of the whole brain. This method combined functional magnetic resonance imaging (fMRI) data with magnetoencephalography (MEG) data using representational similarity analysis and revealed a hierarchical progression from primary visual cortex through the dorsal and ventral streams. To assess the replicability of this method, here we present results of a visual recognition neuro-imaging fusion experiment, and compare them within and across experimental settings. We evaluated the reliability of this method by assessing the consistency of the results under similar test conditions, showing high agreement within participants. We then generalized these results to a separate group of individuals and visual input by comparing them to the fMRI-MEG fusion data of Cichy et al. (2016), revealing a highly similar temporal progression recruiting both the dorsal and ventral streams. Together these results are a testament to the reproducibility of the fMRI-MEG fusion approach and allows for the interpretation of these spatiotemporal dynamic in a broader context.

The manufacturing method influences the properties of the produced components. This work investigates the influence of manufacturing methods such as fused filament fabrication (3D printing) and injection molding on water absorption, mechanical and thermal properties of the specimens produced from neat biobased poly(lactic acid) (PLA) polymer and poly(lactic acid)/wood composites. Acrylonitrile butadiene styrene (ABS) acts as the reference material due to its low water absorption and good functional properties. The printing layer thickness is one of the factors that affects the properties of a 3D printed specimen. The investigation includes two different layer thicknesses (0.2 mm and 0.3 mm) while maintaining uniform overall thickness of the specimens across two manufacturing methods. 3D printed specimens absorb significantly higher amounts of water than the injection molded specimens, and the increase in the layer thickness of the 3D printed specimens contributes to further increased water absorption. However, the swelling due to water absorption in 3D printed specimens decreases on increased layer thickness. Tensile, flexural and impact properties of all the specimens decrease after water absorption while the properties improve on decreasing the layer thickness. Higher porosity on increasing the layer thickness is the predominant factor. The results from dynamic mechanical analysis and microscopy validate the outcomes.

Epidermodysplasia verruciformis (EV) is a rare genodermatosis caused by β-human papillomaviruses (HPV) in immunodeficient patients. EV is characterized by flat warts and pityriasis-like lesions and might be isolated or syndromic, associated with some other infectious manifestations. We report here three patients from 2 independent families with syndromic EV for 2 of them. By whole exome sequencing, we found that patients carry new homozygous variants in STK4, both leading to a premature stop codon. STK4 deficiency causes a combined immunodeficiency characterized by a broad infectious susceptibility to bacteria, viruses and fungi. Auto-immune manifestations were also reported. Deep immunophenotyping revealed multiple cytopenia in the three affected patients, in particular deep CD4+ T cells deficiency. We report here the fourth and the fifth cases of syndromic EV due to STK4 deficiency.

Background: Spinal schwannomas and meningiomas are the most common spinal cord benign tumors in adults and total excision is the goal of the treatment. The traditional surgical approach is performed by total laminectomy, but recently unilateral hemilaminectomy has been recognized as a valuable surgical alternative. We report the clinical results of patients affected by spinal schwannoma and meningioma in whom total laminectomy or unilateral hemilaminectomy were performed. Material and Methods: A retrospective study of patients who underwent resection of spinal meningioma or schwannoma by laminectomy or unilateral hemilaminectomy approaches in our Institute from January 2013 to January 2023 was made. The baseline data of these patients, operative approach and postoperative outcome were compared. Results: The study was performed on 41 patients with mean age of 62.5 ±14.6 years. Our series included 24 (59%) cases of schwannomas and 17 (41%) cases of meningiomas, with a prevalent location in the thoracic spine. The average schwannomas volume was 3,6 ±2,7 cm3, whereas the average meningiomas volume was 1.1 ±0.5 cm3. Total excision was achieved in all cases. Operative time of schwannomas was longer (p=0.001) respect to meningiomas with higher intra-operative blood loss (p=0.000). Total laminectomy approach was performed in 24 out of 41 patients (59%) and unilateral hemilaminectomy approach in 17 out of 41 (41%) patients. Unilateral hemilaminectomy was associated with shorter postoperative bed rest (p=0.003), shorter hospitalization (p=0.028) and lower postoperative pain (p=0.02) respect to total laminectomy. Conclusions: Both spinal schwannomas and spinal meningiomas in various size can be safely and effectively treated with unilateral hemilaminectomy approach. This approach grants more advantages compared with standard total laminectomy, including shorter postoperative bed rest, shorter hospitalization and reduced postoperative pain.

After the ban on tributyltin-based antifouling paints, DCOIT (4,5-Dichloro-2-octylisothiazol-3(2H)-one) became one of the most used antifouling biocides. DCOIT is a pseudo-persistent contaminant in port areas and is toxic to non-target species, but its ability to bioaccumulate and be transferred along the trophic chain remains unknown. This study aimed to preliminarily investigate the bioaccumulation, trophic transfer, and biomagnification of DCOIT and SiNC-DCOIT (DCOIT immobilized in silica mesoporous nanocapsules) from the microalga Tetraselmis chuii to the mussel Mytilus galloprovincialis during exposure experiments considering 24 h of uptake followed by 72 h depuration. Mussels rapidly internalized and metabolized both DCOIT and SiNC-DCOIT. The predator-prey biomagnification factors (BMFTL) suggested that both forms of the biocide can be trophically transferred, with higher concentrations of DCOIT and SiNC-DCOIT in mussels than in microalgae (BMFTL &gt; 1). However, the bioaccumulation and bioconcentration factors indicated a low bioaccumulation capability in the short term, suggesting that the depuration rate overcomes the uptake. Our findings contribute to the development of environmental risk assessments for DCOIT and SiNC-DCOIT, but do not exclude the possibility of DCOIT bioaccumulation in the long-term in areas with constant input of DCOIT. Further studies are needed to understand these processes under continuous exposure scenarios to DCOIT.

(1) Background: The aim of study was to investigate the salt consumption by children and adolescents from the Silesian Province (Poland), taking into account the region’s dietary traditions and number of years of school education. (2) Methods : 300 students aged 10–18 from different types of schools, were enrolled in the study and divided into groups in terms of: school, sex, the state of nutrition. The survey questionnaire about dietary habits, including the frequency and serving size with respect to 12 salty products was used. On the basis of the frequency and the amount of consumed products, as well as the data on salt content, the amount of total daily intake of salt was estimated.; (3) Results: The mean daily intake of salt by children and adolescents was 1.083 g ( 0.433 g of sodium); children aged 10–12 consumed the highest amount of salt (1.296 g/day) compared to pupils aged 13–15 (1.131 g of sodium) and adolescents aged 16–18 (0.863 g/day); (4) Conclusions: With age, as a result of various factors, the consumption of salt declines. The parents impact and the familial socio-environmental factors begin to wane, and other factors start to have influence, e.g. school education of healthy lifestyle, health behavior of peers.

Portugal’s EPAC silo network, initially planned in the 1930s but constructed and utilized primarily in the 1970s, consisted of 31 silos with a total capacity of 841,100 t. The network’s usage declined, however, due to market liberalization and Portugal’s accession to the European Economic Community in 1985. This study focuses on adapting a methodology to inventory and analyse the 31 silos in the EPAC network considering their general features, construction, technological facilities, and socioeconomic aspects. The silos are situated in 30 cities and towns, predominantly in the country’s key grain-growing regions, particularly the Alentejo region. While there are variations in design and construction, most EPAC silos contain two or three rows of circular reinforced-concrete cells and use the spaces between cells for storage. Their capacities range from 6,000 to 35,000 t. Some are inland grain reception and storage silos, while others are larger-capacity port silos designed to unload grain rapidly onto ships using mechanical or pneumatic unloaders. These structures are a significant part of Portugal’s agro-industrial heritage and have in some cases been repurposed as museums or event venues. Compared to other agro-industrial buildings, silos pose unique conversion challenges due to their height and design complexities. Examples of successful reuse in countries like Spain and Italy may provide insights for potential silo projects in Portugal. However, analysis suggests that such proposals and similar initiatives may be viable only in the more highly populated towns.

In this study, alfalfa silage with different packing densities (500 kg/m3, 600 kg/m3 and 700 kg/m3) were set up under outdoor high temperature and indoor normal temperature. The chemical composition, fermentation quality and microbial community of alfalfa silage were analyzed. The results showed that DM and WAC content decreased with the increase of density. When the density is 600kg/m3, CP content reaches the maximum and ADF content is the lowest. Temperature has a certain effect on alfalfa silage. The content of Lactobacillus plantarum fermented at high temperature is lower than that fermented at normal temperature. At the same time, the content of Lactobacillus plantarum decreased with the increase of packing density. However, the content of Lactobacillus plantarum was the lowest when the packing density was 600 kg/m3 at high temperature. In summary, this study explained the effects of different temperature and density on alfalfa fermentation quality and microbial community, and clarified that the density should be reasonably controlled within 600 kg/m3 during alfalfa silage, providing theoretical support for production practice.

Arginine shows Jekyll and Hyde behavior in several respects. It participates in protein folding via ionic and H-bonds and cation-pi interactions; the charge and hydrophobicity of its side chain makes it a disorder-promoting amino acid. Its methylation in histones; RNA binding proteins; chaperones regulates several cellular processes. The arginine-centric modifications are important in oncogenesis and as biomarkers in several cardiovascular diseases. The cross-links involving arginine in collagen and cornea are involved in pathogenesis of tissues but have also been useful in tissue engineering and wound-dressing materials. Arginine is a part of active site of several enzymes such as GTPases, peroxidases, and sulfotransferases. Its metabolic importance is obvious as it is involved in production of urea, NO, ornithine and citrulline. It can form unusual functional structures such as molecular tweezers in vitro and sprockets which engage DNA chains as part of histones in vivo. It has been used in design of cell-penetrating peptides as drugs. Arginine has been used as an excipient in both solid and injectable drug formulations; its role in suppressing opalescence due to liquid-liquid phase separation is particularly very promising. It has been known as a suppressor of protein aggregation during protein refolding. It has proved its usefulness in protein bioseparation processes like ion-exchange, hydrophobic and affinity chromatographies. Arginine is an amino acid, whose importance in biological sciences and biotechnology continues to grow in diverse ways.

Background: Informal caregivers' own quality of life, health status, and determinants are poorly understood despite their concerns for the health of the individuals they assist. Objectives: To compare the quality of life and the health determinants of older informal caregivers with those of older adults without caregiving responsibilities. Methods: An online survey was designed to investigate the quality of life and the health determinants of people aged 65 years and over, with a focus on informal caregivers. In addition to socio-demographic data, the number of informal caregiver and the Zarit scale of caregiver burden were collected. Quality of life (SF-12) and health determinants (access to technology and level of physical activity (IPAQ)) were assessed and compared between informal caregivers and the others. Results: A total of 111 participants (70 ± 3.83 years, 71.2% of women). The majority of respondents (91.8%) were Belgian. One third of the respondents identified themselves as informal caregiver and declared to have severe burden (61.9±15.2/88). Socio-demographic characteristics and access to technology were similar between informal caregivers and non-caregivers (p>0.05). However, informal caregivers have a lower SF-12 score in the mental score domain (44.3±10.2 vs; 50.7±7.0; p=0.004) and a lower level of physical activity (434±312 METS/min/week vs.1126±815 METS/min/week; p=0.01) than their peers. Conclusions: Informal caregivers reported lower quality of life and lower level of physical activity than their peers. Given the recognized importance of physical activity for overall health, this survey highlights the need to promote physical activity among older informal caregivers.

A full potential all-electron density functional method within generalized gradient approximation is used to investigate the electronic, elastic and transport properties of cubic copper sulphide and copper selenide. The electronic structure suggests metallic behavior with a zero energy band gap for both materials. Elastic property calculations suggest a stiff material with the bulk to shear modulus ratio of 0.35 and 0.44 for Cu2S and Cu2Se respectively. The transport properties were estimated using the Boltzmann transport approach. Seebeck coefficient, electrical conductivity, thermal conductivity, and power factor all suggest a potential p-type conductivity for Cu2S and n-type conductivity for Cu2Se.

Regulation at the level of translation plays an essential role in modulating gene expression. Given the importance of knowledge about translationally active mRNAs as an indicator of translation efficiency, it is crucial for researchers to have at their disposal organised sources of functional information on translation - plant translatomic maps similar to transcription maps. The development of a general experimental and computational methodology for constructing translatome maps is essential to address this challenge. In this manuscript, we discuss what researchers can do to design plant translatome maps, namely, we review: (i) experimental methods to obtain translationally active mRNA fractions, considering their advantages and limitations; (ii) additional methodological approaches to obtain complete pools of translationally active mRNAs; (iii) sequencing methods to qualitatively and quantitatively assess different mRNA fractions; and (iv) multivariate analyses of sequencing results by bioinformatics methods, including metrics for assessing mRNA translational activity.

The contribution of genetic and environmental factors to the pathophysiology of cerebral aneurysms in monozygotic twins is under-reported and presents ambiguous arguments. The morphology and hemodynamics of neurovascular arteries in a pair of monozygotic twins (MTs) were investigated to reveal the underlying mechanisms. Four arterial models were reconstructed for the twin A-right brain and left brain, twin B-left brain, and B-left brain without anterior cerebral arteries based on preclinical scanned information. Subsequently, the dimensions, configurations and outlined curves of the three-perspective geometries were compared between the MTs. Adopting an in-vitro validated numerical cerebral aneurysm model, hemodynamic patterns were investigated and compared in the MT models, respectively. Morphological comparisons of the MTs show the size and shape of cerebral arteries exist significant differences, despite of the expected genetic similarities. These differences can be attributed to variations during embryological development and external environmental influences. Qualitatively and generally, numerical results indicate the MTs have some hemodynamic similarities (e.g., time-averaged pressure (TAP) distributions (~13400 Pa), and oscillatory shear index (0~0.49), but present significant differences in specific local arteries due to morphological variances. Specifically, the difference in the volumetric blood flow rate in corresponding arteries between the MTs is from 16% (smallest) in anterior choroidal artery (AChA) to 221% (largest) in the ophthalmic artery (OphA), varying with specific compared arteries. Also, the registered hemodynamic indicators, such as the maximum time-averaged wall shear stress (TWSS) (53.6 Pa vs. 37.8 Pa), and different local OSI distributions were observed between the MTs. The findings revealed that morphological variations in MTs could be generated by embryological and environmental factors, thus assuming they share the identical morphology in cardiovascular and neurovascular systems may lead to significant misevaluations in hemodynamics quantifications and further lesions.

There is evidence that behavioral risk factors such as western type diet, and life style can predispose to oxidative stress, deficiency in antioxidant status, hyperglycemia, dyslipidemia and increase in inflammation in tissues of various organs: beta cells of the pancreas, LDL receptors in the hepatocytes, endothelium, neurons, osteocytes and gut. Further studies indicate that diets rich in antioxidant flavonoids, omega-3 fatty acids and fiber in foods were inversely associated whereas western-type foods were positively associated with risk of mortality due to cardiovascular diseases (CVDs). One important cause for beneficial effects of diet may be certain foods and nutrients such as vegetables, fruits and whole grains that are rich in fiber and flavonoids, known to produce liters og molecular hydrogen in the gut. It seems that, high-fiber diets, prebiotic and probiotics can produce greater hydrogen, which acts as an antioxidant and may inhibit free radical generation. Recent studies indicate that molecular hydrogen can inhibit hydroxyl and nitrosyl radicals and can directly act as antioxidant in the cells and tissues, which can cause marked decline in oxidative stress and inflammation leading to significant decline in CVDs and metabolic diseases. Clinical and experimental studies indicate that hydrogen therapy such as hydrogen rich water can provide benefits in the management of CVDs and metabolic diseases. Larger studies are necessary to verify the role of hydrogen administration in CVDs.

(1)Background: Early-age concrete shrinkage induces stress that impact the cost and service life of concrete pavements. (2)Methods: In this study, strain measurements of field slabs were conducted and a methodology was presented that independently derived autogenous, drying, and thermal shrinkages in the initial stages of concrete placement. Total strain was measured according to five different environmental conditions and shrinkage strain was calculated for each condition. (3)Results: By measuring the strain of the slab and the specimen, the drying shrinkage strain was measured to be approximately 54% better than that by the conventional non-stressed cylinder method because it was possible to measure the drying shrinkage strain at the surface rather than in the middle part of the slab along its depth direction. When the water-to-cement ratio increased (35→40%), there was a considerable reduction (317με→82με) of autogenous shrinkage strain for the concrete at 28 days of age. Furthermore, calculation of stress-dependent strain allowed the presentation of more intuitive and accurate results. (4)Conclusion: As the measurement of independent shrinkage occurrence is possible, the consequent calculated result of the stress-dependent strain acting on real slabs will facilitate improvement in the construction quality, reduction in the development of defects in the concrete structure, and increase in the service life.

With the increased use of laterite nickel ore, the impact of high Al2O3 slag on blast furnace smelting has gradually increased. In this paper, the effects of slag basicity and Al2O3 content on slag viscosity and enthalpy change under constant temperature conditions was investigated. The changes in slag structure were analyzed by activation energy and Fourier Transform Infrared (FT-IR) spectroscopy. The relationship between slag components and slag temperature and viscosity when slag heat is reduced was investigated. The results showed that the viscosity first slightly decreased and then significantly increased with increasing basicity at constant temperature. With the addition of Al2O3 content, the viscosity of the slag increases. The activation energy increases with increasing slag basicity and Al2O3. With increasing basicity, the [SiO4]4- tetrahedral unit trough depth becomes shallow, the [AlO4]5- asymmetric stretching band migrates to lower wave numbers, and the slag structure depolymerizes. With the increase of Al2O3 content, the trough of [SiO4]4- tetrahedra deepens and the center of the symmetric stretching band moves to a higher wave number. The [AlO4]5- asymmetric stretching band becomes obvious, indicating the complexity of the slag structure. When the heat decreases, the slag temperature increases as the basicity increases, and the slag thermal stability is better at the basicity of 0.95-1.05. As the Al2O3 content increases, the thermal stability of the slag becomes worse.

There is a growing consensus that culture influences the perception of facial expressions of emotion. However, little is known about whether and how culture shapes the production of emotional facial expressions, and even less so about whether culture differentially shapes the production of posed versus spontaneous expressions. Drawing on prior work on cultural differences in emotional communication, we tested the prediction that people from the Netherlands (a historically heterogeneous culture where people are prone to low-context communication) produce facial expressions that are more distinct across emotions compared to people from China (a historically homogeneous culture where people are prone to high-context communication). Furthermore, we examined whether the degree of distinctiveness varies across posed and spontaneous expressions. Dutch and Chinese participants were instructed to either pose facial expressions of anger and disgust, or to share autobiographical events that elicited spontaneous expressions of anger or disgust. Using the complementary approaches of supervised machine learning and information-theoretic analysis of facial muscle movements, we show that posed and spontaneous facial expressions of anger and disgust were more distinct when produced by Dutch compared to Chinese participants. These findings shed new light on the role of culture in emotional communication by demonstrating, for the first time, effects on the distinctiveness of production of facial expressions.

The purpose of this study is to determine the equilibrium conditions for the formation of a mixture of propane and normal butane hydrates including temperature, pressure and mole fraction. In order to prevent the formation of hydrates in the cooling path, it is necessary to examine the conditions of hydrate formation and provide solutions. Modeling of hydrate formation conditions was performed using Hydoff software and compared with experimental results in this field, which obtained an acceptable error percentage. The range of temperature is between 267-276 °C and the molar percentage of propane is 0.7,0.8 and 0.9 and the mathematical equation was presented to predict hydrate formation. By analyzing the results, it was found that by increasing the concentration of ethane in the presence of other compounds, hydrate growth increased and hydrates formed more stable, also by increasing the concentration of propane and normal butane the amount of equilibrium pressure will decrease.

ASTM A743 CA6NM alloy is a martensitic stainless steel typically used in energy industry -runners and hydraulic turbine components- due to its superior toughness, yield and fatigue properties. In both the manufacturing, shielded metal arc welding is applied to join for this grade steels. However, weldability of the steels is limited due to formation of hard and brittle phases such as untempered martensite during welding and post weld heat treatment processes. The formation causes a reduction in toughness. In this study, influence of post-weld heat treatment procedure (single tempering and double tempering) and parameters on microstructure and hardness of AWS410NiMo all weld metal. Hardness tests were conducted from weld metal. Microstructures of the all weld metals subjected to different heat treatment process were characterized.

The aim of this study was to examine the post-injury psychological impact looking for to avoid sources of health issues. We have analyzed differences in the stress, anxiety and depression levels between male and female football players who have suffered at least one injury during the last season played respect to similar players who have not been injured. A descriptive cross-sectional design was used. The participants were 187 football players and data on the player’s injuries were collected. A Self-reported Questionnaire collected number, type and severity of injuries sustained during the previous sports season (twelve months), and also the player’s current situation being injured or not injured. To evaluate the psychological variables, the DASS-21 questionnaire was used. Results indicated that the male injured players presented anxiety levels higher than those who were non-injured. When we observe the female players’ data, the stress levels of the non-injured ones are higher than those of the injured players. Regarding the non-injured athletes, results showed that the female non-injured players presented values in anxiety higher than those corresponding to the non-injured male players. Thus, sport injury affects mental health issues such as anxiety and stress, and in a different way regarding gender.

Is it true that the nuclear technology applied to electric energy generation offers a clean, safe, reliable and affordable i.e. sustainable alternative? Yes it is, but its impact on the environment strongly depends on the implementation bearing residual risks due to a human factor, technical failures or natural catastrophes. A full response is therefore difficult and can first be given when the wicked multi-disciplinary problems get well formulated and “solved”. These problems have multi-dimensional nature lying at the interface between: necessary R&D effort, the industrial deployment and the technology impact in view of the environmental sustainability including the management of produced hazardous waste. This enormous complexity indicates that just a description of the problem might represent a problem. The paper proposes a holistic approach to assess the nuclear energy systems potential with respect to sustainable performance applying Multi-criteria decision analysis with a suitable objective tree and a multi-level criteria structure and examines the trading-off techniques for ranking of the alternatives. The framework proposes a multi-criteria and multi-stakeholders treatment which can be used as a pre-decisional support towards an implementation of nuclear fuel cycles adapted to national preferences and priorities. Proposed approach addresses some aspects of the environmental footprint of nuclear energy systems. Advanced nuclear fuel cycles, previously investigated by the NEA/OECD expert group WASTEMAN, are analyzed as a case study. Sustainability facets of waste management, resource utilization and economics are in focus.

Carbon nanotubes (CNTs) possess unique mechanical, physical, electrical and absorbability properties coupled with their nanometer dimensional scale that renders them extremely valuable for applications in many fields including nanotechnology and chromatographic separation. The aim of this review is to provide an updated overview about the applications of CNTs in chiral and achiral separations of pharmaceuticals, biologics and chemicals. Chiral SWCNTs and MWCNTs have been directly applied for the enantioseparation of pharmaceuticals and biologicals by using them as stationary or pseudostationary phases in chromatographic separation techniques such as high-performance liquid chromatography (HPLC), capillary electrophoresis (CE) and gas chromatography (GC). Achiral MWCNTs have been used for achiral separations as efficient sorbent objects in solid-phase extraction techniques of biochemicals and drugs. Achiral SWCNTs have been applied in achiral separation of biological samples. Achiral SWCNTs and MWCNTs have been also successfully used to separate achiral mixtures of pharmaceuticals and chemicals. Collectively, functionalized CNTs have been indirectly applied in separation science by enhancing the enantioseparation of different chiral selectors whereas, non-functionalized CNTs have shown efficient capabilities for chiral separations by using techniques such as encapsulation or immobilization in polymer monolithic columns.

Rich biodiversity is one of the Philippines’ greatest assets. Unfortunately, there is a continuous decline in the diversity of flora and fauna across the world. This calls for the need to educate people, especially younger generations, to value and protect biodiversity and natural resources. The study aimed to assess the students’ extent of knowledge and identify their perspectives towards biodiversity and its protection and conservation. A total of 268 randomly selected students at Aurora State College of Technology Zabali Campus were involved in the study. Survey questionnaires were used to obtain data and information which were subjected to statistical tests. The students had a moderate knowledge level on biodiversity with a mean score of 6.65 out of 10 items (SD = 1.50). Their perspective on biodiversity was leaning toward its protection and conservation, with a mean score of 7.2 out of 10 items (SD = 1.29). Factors affecting the students’ knowledge were gender (p = .003) and academic department (p = 0.003). Females and those associated with the Department of Forestry and Environmental Sciences and Department of Industrial technology were found to have more knowledge than the others. Males, on the other hand, were found to have a more positive perspective towards biodiversity. Knowledge and perspective had a weak correlation with r = 0.39. Students were not well-aware, but were in support of the Philippines’ biodiversity-related laws, which could help shape their mindset and actions towards biodiversity conservation and protection. As an implication, the college administration must revisit the curricula of all degree programs and ensure that students from each degree program are environmentally educated, emphasizing biodiversity conservation.

This paper focuses on distributed generation (DG) controller of a PV based Micro Grid. An independent DG controller (IDGC) is designed for PV applications to improve maximum power point tracking (MPPT) in Micro Grid (MG). Extreme learning machine (ELM) based MPPT method exactly estimate the reference input of converter control. They are voltage and current at MPP. Feedback controls employ linear PI schemes or nonlinear, intricate techniques. Here the converter controller, IDGC is improved by measuring directly converter outputs like duty cycle. PWM index in a single DG PV-based MG. It introduces a fast learning Extreme Learning Machine (ELM) using Moore-Penrose pseudo-inverse and an online-sequential ridge re method for robust CR estimation. The approach ensures the stability of the microgrid during PV uncertainties. Internal DG control approach (IDGC) improves the strength of the Micro Grid during, three-phase faults at load bus, partial shading, irradiance change, islanding operation and load change. The model is designed and simulated in MATLAB/SIMULINK platform and some of the results are validated in hardware in simulation (HIL) platform.

In this article, we propose a machine learning based fine-grained vehicle classification method VehiClassNet, which effectively solves the challenges of precise vehicle recognition and classification in intelligent transportation systems by combining multi-scale feature extraction, cross modal fusion, and attention mechanisms. Our model demonstrated excellent performance on the Stanford Cars-196 dataset. The innovation of this study lies in its advanced multi-scale feature extraction, cross modal fusion, and attention mechanism. It not only improves classification accuracy, but also lays the foundation for further research on intelligent transportation systems and autonomous vehicle technology.

This paper examines the impact of random sample sizes on the extreme value theory of competing risks, a significant area in finance and environmental science. We capture limit distributions of two extreme types under random sampling sizes, known as accelerated mixed l-max and p-max stable type distributions. The study presents results for both maxima and minima in competing risks scenarios, addressing cases of independent and non-independent random sample sizes. Numerical examples validate our theoretical findings, demonstrating the applicability of our approach to various random sample size distributions, including time-shifted Poisson or binomial, geometric, and negative binomial distributions.

South Africa’s internationally celebrated water legislation placed the responsibility for investing in water services at the door of the government. In recent years South Africa has struggled to invest adequately to keep up with growing demand for these services. The result is a suite of social, economic and environmental risks that are destabilising to the fiscus and the financial sector. This paper explored both operating and capital costs, and applied the ‘Beyond the Gap’ analysis to show that an additional 55% investment (R91 billion annually) is necessary to ensure South Africa meets its water policy goals. The analysis explores the factors that influence the investment amount and shows that a combination of policy choices and exogenous factors such as climate change could render the investment gap anywhere between 30% and 90% of the estimated current allocation to the water sector. The most significant savings are attributed to reducing the extent of “non-revenue water”, an energy transition away from coal, sharing of some water taps between (up to) five houses, reduced water allocations to agriculture, investments in invasive alien plant (IAP) clearing in water catchments above dams, and water demand management, capacity building and more efficient integration of different bulk water schemes. The study revealed important dependencies between capital and operating costs; where operating costs are ignored, the decay of water infrastructure is accelerated. Showing the contingency of investment needs on policy choices, places responsibility for attaining water policy goals and SDG 6 in the hands of a diverse set of actors. Quantifying the investment need also raises the critical question of how to raise the required investment. Recognising the need to balance risks to financiers with the widespread risks to households, companies and government when investment in water services is inadequate, South Africa is exploring a Monetary Architecture approach of inter-balance sheet relationships in an attempt to mobilise investment from new sources.

Abstract: Circumcision is a long-standing and frequently performed surgical procedure which holds significant cultural significance among AmaXhosa people in South Africa. Due to cultural reasons in some parts of Africa, the integration of medical male circumcision with traditional manhood initiation rituals still lacks acceptance. This study examined the level of knowledge and acceptance of voluntary male medical circumcision (VMMC) among young males in a selected high school in the Nyandeni District of the Eastern Cape Province, South Africa. A descriptive, quantitative, cross-sectional study was conducted, and a self-administered questionnaire was used to obtain information on sociodemographic characteristics, knowledge of VMMC, percep-tions of VMMC, and circumcision practices. One Hundred participants were recruited from both grades 11 and 12, and 82% of the participants indicated that they had received information about VMMC. Most of the respondents (88%) preferred traditional male circumcision (TMC) and only 12% of respondents preferred VMMC. The participants displayed a good understanding of the distinction between VMMC and TMC. However, results from the study showed that most re-spondents exhibited low acceptability towards VMMC. These findings highlight the need to develop evidence-based strategies to enhance learners’ knowledge and acceptance of VMMC.

The increasing prevalence of species that are detrimental to biodiversity is a major concern, particularly for managers of National Parks. To develop effective programs for controlling weeds, it is essential to have a thorough understanding of the extent and severity of infestations, as well as the contributing factors such as temperature, rainfall, and disturbance. Predicting these factors on a regional scale requires models that can incorporate a wide range of variables in a quantifiable manner, while also assisting with on-ground operations. In this study, we present two Bayesian Network models specifically designed for six significant weed species found along the southern coast of Australia. Our models are based on empirical data collected during a coastal weed survey conducted in 2015 and repeated in 2016. We applied these models to the coastal national parks in the isolated and pristine East Gippsland region. Importantly, the prediction models were developed at two different spatial scales that directly corresponded to the scale of the observations. Our findings indicate that coastal habitats, with their vulnerable environments and prevalence of open dune systems, are particularly susceptible to weed infestations. Moreover, adjacent regions also have the potential for colonization if these infestations are not effectively controlled. Climate-related factors play a role in moderating the potential for colonization, which is a significant concern for weed control efforts in the context of global climate change.

Candida auris is considered an emerging Candida species that has rapidly spread all over the world. The evidence of its origin and emerging resistance is still unclear. The severe infection by this species causes significant mortality and morbidity among the elderly and immune compressed individuals. Development of drug resistance is the major factor associated with therapeutic failure of existing antifungal agents. Previous studies addressed the antifungal resistance profile and drug discovery for C. auris. However, comprehensive coverage of these information in a single investigation yet to be available. In this review, we have mainly focused on recent development in therapeutic strategy against C. auris. Based on the available information, several differential approaches were discussed, including existing antifungal drugs, chemical compounds, essential oils, natural products, antifungal peptides, immunotherapy, antimicrobial photodynamic therapy, drug repurposing, and drug delivery systems. Among them, chemical medications, natural products, and antifungal peptides are the prime contributors. However, a limited number of resources are available to prove the efficiency of these potential therapies in clinical usage. Hence, we hope that the data gathered in this review can encourage in vivo studies and clinical trials.

The redshifted 21 cm line signal is a powerful probe of the cosmic dawn and the epoch of reionisation. The global spectrum can potentially be detected with a single antenna and spectrometer. However, this measurement requires an extremely accurate calibration of the instrument to facilitate the separation of the 21 cm signal from the much brighter foregrounds and possible variations in the instrument response. Understanding how the measurement errors propagate in a realistic instrument system and affect system calibration is the focus of this work. We simulate a 21 cm global spectrum observation based on the noise wave calibration scheme. We focus on how measurement errors in reflection coefficients affect the noise temperature, and how typical errors impact on the recovery of the 21 cm signal, especially in the frequency domain. Results show that for our example set up, a typical VNA measurement error in the magnitude of the reflection coefficients of the antenna, receiver, open cable which are 0.001, 0.001, 0.002 (linear) respectively would result in a 200 mK deviation on the detected signal, and a typical measurement error of 0.48∘, 0.78∘, 0.15∘ in the respective phases would cause a 40 mK deviation. The VNA measurement error can greatly affect the result of a 21 cm global spectrum experiment using this calibration technique, and such a feature could be mistaken for or be combined with the 21 cm signal.

Geopolymer concrete (GPC) represents an innovative green and low-carbon construction material, offering a viable alternative to ordinary Portland cement concrete in building applications. However, existing studies tend to overlook the recyclability aspect of GPC for future use. Various structural applications necessitate the use of concrete with distinct strength characteristics. The recyclability of the parent concrete is influenced by these varying strengths. This study examined the recycling potential of GPC across a spectrum of strength grades (40, 60, 80 and 100 MPa, marked as C40, C60, C80 and C100) when subjected to freeze-thaw conditions. The cementitious material comprised 60% metakaolin and 40% slag, with natural gravel serving as the coarse aggregate, and the alkali activator consisting of sodium hydroxide solution and sodium silicate solution. The strength of the GPC was modulated by altering the Na/Al ratio. After 350 freeze-thaw cycles, the GPC specimens underwent crushing, washing, and sieving to produce recycled geopolymer aggregates (RGAs). Subsequently, their physical properties and microstructure were thoroughly examined. The findings indicated that GPC with strength grades of C100, C80, and C60 were capable of enduring 350 freeze-thaw cycles, in contrast to C40, which did not withstand these conditions. RGAs derived from GPC of strength grades C100 and C80 complied with the criteria for Class II recycled aggregates, whereas RGAs produced from GPC of strength grade C60 aligned with the Class III level. A higher strength grade in the parent concrete correlated with enhanced performance characteristics in the resulting recycled aggregates.

The theory of heavy ion double charge exchange (DCE) reactions proceeding by effective rank–2 isotensor interactions is presented. Virtual pion–nucleon charge exchange interactions are investigated as the source for induced isotensor interactions, giving rise to the Majorana DCE (MDCE) reaction mechanism. MDCE is of a generic character, proceeding through pairs of complementary (π±,π∓) reactions in the projectile and target nucleus. The dynamics of the elementary processes is discussed where the excitation of pion–nucleon resonances are of central importance. Investigations of initial and final state ion–ion interactions show that these effects are acting as vertex renormalizations. In closure approximation, well justified by the finite pion mass, the second order transition matrix elements reduce to pion potentials and effective two–body isotensor DCE interactions, giving rise also to two–body correlations in either of the participating nuclei. Connections to neutrinoless Majorana double beta decay (MDBD) are elucidated at various levels of dynamics, from the underlying fundamental electro–weak and QCD scales to the physical scales of nuclear MDBD and MDCE physics. It is pointed out that heavy ion MDCE reactions may also proceed by competing electro–weak charge exchange processes, leading to lepton MDCE by electrons, positrons, and neutrinos.

Two strongly curved areas of the Carpathians in Romania are earthquake-prone: Vrancea - in the South-Eastern Carpathians, and Danubian – in the western edge of the Southern Carpathians. By far the highest seismicity episode in 2023 was recorded in the Southern Carpathians, near Targu Jiu city, of more than 4000 earthquakes. A first ML 5.2 mainshock was recorded on 13 February, followed by a second one, ML 5.7, on 14 February. Our purpose is to provide a first analysis of this sequence in order to explain its extent and unusual development, in time. The possible role of fluids in the middle crust, is discussed in connection with the rather unusual character of the space-time distribution of aftershocks. A large and high-quality dataset is provided by the dense array of seismic stations which has been gradually improved by adding new stations in the epicentral area. The thorough revision of the phase picking and location reveals a few interesting and intriguing features of seismicity that still remain worthy to be further investigated. The database built within this paper provides excellent information not only for Targu Jiu area, but for any other investigation in intra-continental regions characterized by diffuse and sporadic seismic activity.

Paramedics are increasingly being subjected to violence, creating the potential for significant physical and psychological harm. Where a patient has a history of violent behavior, hazard flags - applied either to the individual, their residential address, or phone number - can alert paramedics to the possibility of violence, potentially reducing the risk of injury. Leveraging a novel violence reporting process embedded in the electronic patient care record, we reviewed violence reports filed over a thirteen-month period since its inception in February 2021to assess the effectiveness of hazard flagging as a potential risk mitigation strategy. Upon reviewing a report, paramedic-supervisors can generate a hazard flag if recurrent violent behavior from the patient is anticipated. In all, 502 violence reports were filed, for which paramedic-supervisors generated hazard flags in 20% of cases (n=99). In general, cases were not flagged either because the incident occurred at a location not amenable to flagging, or because the supervisors felt that a hazard flag was not warranted based on the details in the report. Hazard flagging was associated with an increased risk of violence during subsequent paramedic attendance (Odds Ratio [OR] 6.21, p

This study investigated the anatomical characteristics and pulp quality of tapped Styrax sumatrana wood to facilitate its further utilization. The transverse surface of the tapped S. sumatrana was light or greyish brown in the sapwood and reddish brown in the heartwood. The resin canals of the tapped wood were formed along the growth rings at the boundaries between the heartwood and sapwood. Furthermore, microscopic analyses revealed an irregular outline and rounded epithelial cells at the edges of the intercellular traumatic resin canal (TC). Approximately 8–16 epithelial cells surrounded the resin canals. The fibers in the tapped S. sumatrana were generally thin-walled, whereas those near the TC were thick-walled. Moreover, S. sumatrana were diffuse-porous and exhibited intermediately distinct or indistinct growth ring boundaries. The vessels were mainly in radial multiples and clusters of 3–5. In addition, they showed a diagonal-to-radial pattern arrangement and a few tangential bands. Deposits were observed in some vessels in the tapped part but were absent in the untapped part. The fiber length of the tapped S. sumatrana wood was classified as moderate to extensive and categorized as 2nd grade pulp quality. Finally, the cell walls were classified as thin to moderate.

Diabetes Mellitus (DM) is a chronic metabolic disease consisting of Type 1 or Type 2 diabetes. Although treatment of Type 1 diabetes primarily involves insulin therapy, inhibitors of sodium glucose co-transporters (SGLT’s) are a promising new therapeutic. Of particular interest are the two family members, SGLT1 and SGLT2 that collectively contribute to 100% of filtered glucose reabsorption within the kidneys. Consequently, sole SGLT2 inhibitors (SGLT2i) and dual SGLT1/2 inhibitors (SGLT1/2i) contribute to reducing blood glucose levels by reducing glucose reabsorption and promoting glucosuria and natriuresis. Research from our team on SGLT2i, showed that there is a compensatory mechanism whereby SGLT1 is upregulated. This therefore may warrant the combined use of SGLT1/2i. Our in vitro results demonstrated that whilst both the sole SGLT2i empagliflozin (EMPA) and dual SGLT1/2i sotagliflozin (SOTAG) significantly reduce glucose uptake within HK2 cells, the latter was more effective. In addition, our in vitro results indicate significantly more pronounced upregulation of SGLT1 protein with EMPA compared to SOTAG. Our in vivo mechanistic findings demonstrated that SGLT1/2i significantly increased renal SOD1 levels, whilst SGLT2i significantly elevated renal SOD2 levels. Therefore, our study highlighted that SGLT2i and SGLT1/2i differentially regulate protective anti-oxidant proteins in the kidney.

Ependymoma is responsible for 8–10% of all pediatric brain tumors and constitutes the third most common brain tumor in children. No robust molecular markers are yet in routine clinical use. Surgical resection and adjuvant radiotherapy cure approximately 40-70% of pediatric patients with ependymoma. In our centre, we have been using prophylactic valproic acid treatment for brain tumor patients. Initial observations indicated that valproate could have a beneficial effect in the survival of patients. Recent observations by other authors have shown that patients with glioblastoma benefited from the treatment with valproic acid, a histone deacetylase inhibitor. We have used random survival forest, a novel ensemble survival modelling method to study a single- center, small number cohort of pediatric patients with ependymoma. This analysis has confirmed surgery resection extent and treatment with radiotherapy as independent predictors of overall survival. Treatment with valproic acid was also a predictor of higher survival in this cohort. These results highlight the potential usefullness of the random survival forest model in gathering information from retrospective data. More data is needed about the possible influence of histone deacetylase inhibition by valproic acid in the survival of patients with ependymoma.

Embryonic development proceeds through a series of differentiation events. The mosaic version of this process (binary cell divisions) can be analyzed by comparing early development of Ciona intestinalis and Caenorhabditis elegans. To do this, we reorganize lineage trees into differentiation trees using the graph theory ordering of relative cell volume. Lineage and differentiation trees provide us with means to classify each cell using binary codes. Extracting data characterizing lineage tree position, cell volume, and nucleus position for each cell during early embryogenesis, we conduct several statistical analyses, both within and between taxa. We compare both cell volume distributions and cell volume across developmental time within and between single species and assess differences between lineage tree and differentiation tree orderings. This enhances our understanding of the differentiation events in a model of pure mosaic embryogenesis and its relationship to evolutionary conservation. We also contribute several new techniques for assessing both differences between lineage trees and differentiation trees, and differences between differentiation trees of different species. The results suggest that at the level of differentiation trees, there are broad similarities between distantly related mosaic embryos that might be essential to understanding evolutionary change and phylogeny reconstruction. Differentiation trees may therefore provide a basis for an Evo-Devo Postmodern Synthesis.

In this paper we will provide a new equation that explains why there are three generations or families of leptons and quarks, respectively. We will also explain why all those particles have the known mass ratios amongst their three respective generations and flavors. We will also tackle the problem of Yukawa couplings being arbitrary parameters in the Standard Model Higgs mechanism, which is a long standing problem do to their formulaic dependence on the Higgs Vacuum Expectation Value (VEV). We will attempt to solve this problem and provide a strong argument through an equation for Yukawa couplings of all leptons and quarks via a new methodology that depends on the running of the fine-structure constant on the Q scale, quantum numbers and the Weinberg angle (also on the Q scale). We will also make predictions for all three left-chiral neutrino mass eigenstates and we will provide upper limits for the three right-chiral neutrino mass eigenstates

The most relevant fungal disease of the olive tree in Portugal is anthracnose, which has negative effects on fruit destruction and consequently on the yield and quality of the olive oil. Moreover, the loss of quality caused by olive fruit fly is associated with the presence of fungi in the galleries made by the larvae. The present study focuses on the effect of olive anthracnose and olive fly on the content of bioactive compounds, namely on hydroxytyrosol (HYT) and its derivatives (health claim) in olive oils extracted from 'Galega Vulgar' and 'Cobrançosa' cultivars. The olives, with different damage levels (olive fly and anthracnose disease), were harvested in Castelo Branco (Center of Portugal) in organic rainfed orchards, at four harvest times during 2019, 2020 and 2021 harvest years. The fruits were immediately submitted to olive oil extraction. The results of the quality criteria show that Galega olive oils extracted from olives with a higher anthracnose incidence show no conformity for the Extra Virgin Olive Oil (EVOO) and Virgin Olive Oil (VOO) categories, with high acidity values and negative sensory notes accompanied by the disappearance of oleacein (the main phenolic compound of both monovarietal olive oils). Conversely, no sensory defects were observed in Cobrançosa olive oils extracted from fruit with high anthracnose and olive fly incidence. Moreover, despite a decrease in all the positive attributes associated with the cultivar, namely in oleacein and oleocanthal contents, quality criteria were still in accordance with the EVOO category. The total HYT and tyrosol (TYR) content (&gt; 5 mg/20g) allows the use of the health claim on the label of all the analysed Cobrançosa olive oils.

PM2.5 levels affect human health. However, its relationship with other health vulnerability determinants has not been sufficiently explored. Furthermore, public access to PM2.5 datasets, linkable to health statistics, is not available. We built a georeferenced database and map of annual mean PM2.5 emissions and air concentrations values in Argentina in 2010 and explored their correlations with other health vulnerability determinants. We obtained data for montlhy PM2.5 values emissions and air concentrations in Argentina from public sources. We evaluated health vulnerability by the “Sanitary Vulnerability Index (SVI)”. Non-parametric correlations between variables below 0.22, corresponding to a R2=5%, were deemed meaningless. PM2.5 emissions concentrated in urban and intensive agricultural areas of Argentina. PM2.5 air concentrations were acceptable (≤10 microg/m3) in only 15% of the Argentinean territory, respectively. The correlation between air concentration of PM2.5 and human emission was meaningless. Emissions, but not air concentrations correlated &gt;0.22 with indicators of human activity. SVI correlated meaninglessly with PM2.5 air concentration. In conclusion, PM2.5 levels were above acceptable levels in 85% of the Argentinian territory in 2010. The lack of meaningful correlations between PM2.5 and SVI suggest that these coefficients might be used in combination to assess health vulnerability. Further research is warranted.

Congenital Disorders of Glycosylation (CDG) are a heterogenous group of primarily autosomal recessive mendelian diseases caused by disruptions in the synthesis of lipid linked oligosaccha-rides and their transfer to proteins. CDGs affect multiple organ systems and vary in presentation, even within families. Here we describe a chemically induced mouse mutant, tvrm76, with early onset photoreceptor degeneration. The recessive mutation was mapped to Chromosome 9 and as-sociated with a missense mutation in the Dpagt1 gene encoding UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase (EC 2.7.8.15). The mutation is predicted to cause a substitution of aspartic acid with glycine at residue 166 of DPAGT1. Increased expression of Ddit3, and elevated levels of HSPA5 (BiP) sug-gest the presence of early-onset endoplasmic reticulum (ER) stress. These changes were associated with induction of photoreceptor apoptosis in tvrm76 retinas. Mutations in human DPAGT1 cause Myasthenic Syndrome 13 and severe forms of Congenital Disorder of Glycosylation Type Ij. In contrast, Dpagt1tvrm76 homozygous mice present with congenital photoreceptor degeneration without overt muscle or muscular junction involvement. Our results suggest the possibility of DPAGT1 mutations in human patients that present primarily with retinitis pigmentosa with little or no muscle disease. Variants in DPAGT1 should be considered when evaluating cases of non-syndromic retinal degeneration.

The present study focuses on the investigation of fatigue, social support and quality of life that characterizes social workers. Furthermore, the study aims to highlight the effect of demographic and occupational characteristics on the above factors. A total of 400 social workers with an average age of 39.05 years took part in the research. Most were women, single, residents of cities of more than 100,000, and health care workers. Participants were asked to answer online questionnaires (FAS for fatigue, MSPSS for social support and GHQ-28 for quality of life). From the analysis of the data, it was found that the level of fatigue of the social workers is at low levels. At the same time, the level of occurrence of negative symptoms is also low, with physical symptoms appearing more often than the rest. Participants receive a high level of support from their environment, and more so from the "significant other" in their life. Finally, it was found that the fatigue, social support and quality of life of social workers is affected by the age of the social workers, the total years of service, gender, marital status, place of residence, employer and position of responsibility.

The production of photovoltaic modules is increasing to reduce greenhouse gas emissions. However, this results in a significant amount of waste at the end of their lifespan. Therefore, recycling these solar panels is important for environmental and economic reasons. However, collecting and separating Crystalline silicon, Cadmium Telluride, and Copper indium gallium selenide panels can be challenging, especially in underdeveloped countries. The innovation of this work is to develop a process to recycle all solar panel waste. The dissolution of all metals is studied through the leaching process as the main step of the flowchart. In the first step of leaching, silver can be recovered 98% by 0.5 nitric acid. Then, the second and third step involves the use of glycine for base metals dissolution, followed by the leaching of valuable metals with hydrochloric acid. The effect of parameters such as initial pH, acid concentration, solid/liquid ratio, and Hydrogen peroxide concentration are studied. The results show that Cu, Pb, Sn, Zn, Cd, In, Ga, and Se can be recovered until about 100% under optimal conditions. The optimal conditions for the dissolution of Cu, Zn, and Cd were the glycine concentration of 0.5 M, Temperature of 25 ˚C, the solid/liquid ratio of 10 gr/l, and 1% of Hydrogen peroxide. The optimized glycine concentration for the leaching of lead and tin was 1.5M. Indium and gallium were recovered to 100% by the use of 5M Hydrochloric acid, S/L=10gr/l, and T=45 ˚C. Separation of selenium and tellurium occurred by 0.5 M HCl at a temperature of 60 ˚C. Additionally, for the first time, a general outlook for the recycling of various end-of-life solar panels is suggested.

The concentration of total suspended particles (TSP) and nanoparticles (PM0.1) over Hat Yai city, Songkhla province, southern Thailand was measured in 2019. Organic carbon (OC) and elemental carbon (EC) were evaluated by carbon aerosol analyzer (IMPROVE-TOR) method. Thirteen trace elements including Al, Ba, K, Cu, Cr, Fe, Mg, Mn, Na, Ni, Ti, Pb, and Zn were evaluated by ICP-OES. Annual average TSP and PM0.1 mass concentrations were determined to be 58.3 ± 7.8 and 10.4 ± 1.2 µg/m3, respectively. The highest levels of PM occurred in the wet season with the corresponding values for the dry seasons being lower. The annual average OC/EC ratio ranged from 3.8 - 4.2 (TSP) and 2.5 - 2.7 (PM0.1). The char to soot ratios were constantly less than 1.0 for both TSP and PM0.1, indicating that land transportation is the main emission source. A principal component analysis (PCA) revealed that road transportation, industry, and biomass burning are the key sources of these particles. However, PM arising from Indonesian peatland fires causes an increase in the carbon and trace element concentrations in southern Thailand. The findings make useful information for air quality management and strategies for controlling this problem, based on a source apportionment analysis.

Between 11 to 15 February 2019, a dust storm originating from Central Australia with persistent westerly and south westerly winds caused high particles concentration at many sites in the state of New South Wales (NSW), both inland and along the coast. The dust continued on to New Zealand and to Antarctica in the south east. This study uses observed data from air quality monitoring stations in NSW and New Zealand, MODIS 3km AOD (Aerosol Optical Depth) product from Terra/Aqua and lidar aerosol profile from CALIPSO (Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observations) satellite data, and the Weather Research Forecast WRF-Chem model based on GOCART-AFWA (Goddard Chemistry Aerosol Radiation and Transport – Air Force and Weather Agency) dust scheme and GOCART aerosol and gas-phase MOZART (Model for Ozone And Related chemical Tracers) chemistry model to study the long-range transport of aerosols for the period 11 to 15 February 2019 across eastern Australia and onto New Zealand and Antarctica. Wild fires also happened in northern NSW at the same time and their emissions are taken into account in WRF-Chem model by using Fire Inventory from NCAR (FINN) as emission input. Modelling results by the WRF-Chem model show that for the Canterbury region of South Island of New Zealand, peak concentration of PM10 (and PM2.5) as measured on 14 February 2019 at 05:00 UTC at the monitoring stations of Geraldine, Ashburton, Timaru and Woolston (Christchurch), which are more than 100km from each other and at Rangiora, Kaiapoi about 2 hours later, correspond to the prediction of high PM10 due to intrusion of dust to ground level from transported dust layer above. The Aerosol Optical Depth (AOD) observation data from MODIS Terra/Aqua and CALIOP lidar measurements on board CALIPSO satellite also indicate that high altitude of dust, originated from this dust storm event in Australia, was located above Antarctica. This study suggests that at present dust storms in Australia can transport dust from sources in Central Australia to the Tasman sea, New Zealand and Antarctica. This process has been going on for at least the last 170k years as indicated by dust found in ice cores from Antarctica and sediment records in the Tasman Sea.

This study investigates the influence of pyrolysis temperature on the main properties of BSG (brewer's spent grain) biochar and evaluates its suitability as an energy vector and as a substrate component. Pyrolysis tests were carried out at 673, 773, and 873 K. Bioenergy indexes were calculated for BSG and its biochar, and germination tests were carried out to obtain lentil sprouts. The results showed that the BSG biochar obtained at the lowest temperature biochar presented the best performance for use as biofuel. Regarding the germination tests, the different biochars were applied at 4 doses, and the evaluated parameters such as germination percentage, germination rate, mean germination time, and seed vigor were strongly influenced by the biochar addition. The biochar at 773 K added at a dose of 5% doubled the values of mean germination time, seed vigor, and time for 50% of the seeds to emerge compared to the control, constituted only with distilled water. The sustainable BSG valorization through pyrolysis reduces waste and contributes to circular economy practices by transforming industrial by-products into valuable resources for energy and agriculture. This approach highlights the importance of sustainability in reducing the environmental impact of industrial waste and promoting renewable energy sources.

This study evaluated the anti-inflammatory effects, protection of gut barrier integrity, and stimulation of phagocytosis in peripheral cells of a nutritional supplement based on a synergistic combination of yeast-based ingredients with a unique 1,3/1,6-glucan complex and a consortium of postbiotic Saccharomyces cerevisiae rich in selenium and zinc. The anti-inflammatory effect in Caco-2 cells in the presence and absence of a pro-inflammatory challenge (tumour necrosis factor alpha [TNF-α]/interferon gamma [IFN-ɣ]) showed statistically significant reductions of IFN-ɣ induced protein-10 (IP-10), and monocyte chemoattractant protein-1 (MCP-1) levels vs. controls (p &lt; 0.001). Disruption of the gut integrity in the presence or absence of Escherichia coli (ETEC H10407) showed transepithelial electrical resistance (TEER) values higher in the ABB C1® group after 6 hours of testing. Spontaneous build-up of the gut epithelium monolayer over 22 days was also greater in the ABB C1® condition vs. a negative control. ABB C1® showed a significantly higher capacity to stimulate phagocytosis as compared with controls of algae β-1,3-glucan and yeast β-1,3/1,6 glucan (p &lt; 0.001). This study supports the mechanism of action by which ABB C1® may improve the immune response and be useful to prevent infection and allergy in clinical practice.

This study addresses the influence of working conditions on Work-Related Quality of Life (WRQOL) among Spanish healthcare professionals. The research seeks to elucidate the mediating roles of job engagement and burnout, and the moderating effects of resilience and self-efficacy, in this relationship. Methods: The study included 374 healthcare workers from Spain, encompassing physicians, nurses, and nursing assistants. It employed a methodological approach using validated instruments to assess psychosocial risks, work-life quality, job engagement, burnout, and resilience. Data were gathered through self-reported questionnaires. Results: Key findings indicate a negative association between working conditions and WRQOL. Job engagement and burnout significantly mediated this relationship, accounting for 19% to 33% of the variance in WRQOL. Notably, lack of support emerged as a strong negative factor for work-related quality of life. Additionally, resilience moderated the relationship between lack of support and burnout. Conclusions: The study concludes that improving working conditions could increase WRQOL. Interventions aimed at enhancing engagement and addressing burnout may be effective. The moderating role of resilience suggests that strategies to enhance resilience could also be beneficial. These findings hold significant implications for policy formulation and human resources planning in healthcare, emphasizing the need for enhanced workplace support and the development of resilience among health workers.

In our discipline, some numbers, facts and methods are established and unquestionable. Still, a credible source is hard to find. Likewise, some state-of-the-art papers do not have the right focus, or they do not point at current research trends and future mission statements. Lastly, reliable resources for claims and statements that are arguable are not always found in the typical journals of our field. The paper at hand solves this issue for our field. Through critical review of a vast amount of journal papers, monographs, handbooks, conference proceedings and theses as well as manuals, textbooks and tutorials, numbers, facts, methods, claims statements, state-of-the-art, research and application trends are reflected and substantiated.

Objective: To analyze the clinical efficacy and safety of monotherapy and dual therapy in patients with early ischemic stroke. Methods: The study was conducted from August 2020 to August 2021, and 80 patients with early ischemic stroke who received treatment at our hospital during this period were selected as the study population. They were randomly divided into a control group and an observation group, with 40 patients in each group. The control group received conventional monotherapy, while the observation group received conventional dual therapy. The efficacy and safety indicators of the two groups were compared.Results: The treatment efficacy, functional recovery, blood indicators, and inflammation markers in the observation group were all superior to those in the control group (all, P<0.05); there was no significant difference in the drug safety profile between the two groups (P>0.05).Conclusion: The dual antiplatelet therapy is more ideal than monotherapy for treating patients with early ischemic stroke. It can further promote the recovery of neurological and cognitive function, improve hematological and inflammatory response indicators in patients, and the safety of this regimen is comparable to monotherapy.

The broad bean plant contains L-DOPA, a compound that is essential for patients with Parkin-son’s disease. However, little has been reported on other broad bean compounds that have bene-ficial effects on health. The objective was to evaluate plants of four Mexican broad bean varieties to determine the content and yield of total phenolic compounds (TPC), total flavonoids (TF), and L-DOPA, as well as to analyze the flavonoid profile and antioxidant (AA) and anti-inflammatory (AANTI) activity in vitro. Broad bean seeds were sown in the field and plants were harvested 20 days after emergence. The analyses were performed with visible UV spectrophotometry and HPLC. The variety José María produced the highest yield of TPC (9.30 g m-2), TF (8.08 g m-2) and L-DOPA (5.64 g m-2) per unit of area. The highest yields per plant were obtained with the Rojita variety: TPC (0.25 g plant-1), TF (0.21 g plant-1) and L-DOPA (0.17 g plant-1). This variety also had the highest antioxidant (CI50= 87.68 µg mL-¹) and anti-inflammatory (CI50= 74.40 mg mL-1) activi-ty, which was attributed to the L-DOPA compounds and to rutin and isoorientins, respectively. The flavonoid profile revealed the presence of rutin and isoorientins, which had not been previ-ously detected in the broad bean plant.

The goal of this study was to analyze the instability during stepping of young and older adults at fast and spontaneous speed. To this aim, the anteroposterior and the mediolateral distances between the body center of mass (COM) and the minimum moment axis (MMA) were computed. A total of 15 young adults (25y.o. [19-29]) and 15 older adults 68.7y.o. [63-77] volunteered for this study. For the computation of the distances, a complete biomechanical protocol combining two force platforms and a 3D motion capture analysis system was setup. The subjects were equipped with 47 reflective markers and were modeled as a frictionless multibody with 19 segments, 18 joints and 42 degrees of freedom and were asked to perform a stepping at both speeds. The stepping was divided in 5 phases with successive swing and double stance phases. The greater instability was observed during the swing phases. The distances indicate a significant higher instability at fast speed for both groups (p &lt; 0.001) for all the phases. The anteroposterior distance also increases significantly for older adults highlighting greater instability while no differences were observed for the mediolateral distance all along the 5 phases suggesting higher risks of backward of forward falls during stepping.