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Salah Laaraj, Hanane Choubbane, Aziz Tikent, Amal Elrherabi, Ayoub Farihi, Meriem Laaroussi, Mohamed Bouhrim, Abdelaaty A. Shahat, Younes Noutfia, Rashed N. Herqash, Fatiha Chigr, Souad Salmaoui, Kaoutar Elfazazi

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: immature carob pulp; phytochemical compounds; antioxidant activity; in silico; in vitro and in vivo studies; antidiabetic agent

Online: 26 August 2024 (16:51:23 CEST)

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Ceratonia siliqua L. is a medicinal plant that has long been used in traditional Moroccan medicine to treat many diseases. This study aimed to assess the impact of the stages of the immature phase of carob pulp (M1, M2, M3, M4, and M5) on phytochemical composition, antioxidant activity, and antidiabetic activity of Ceratonia siliqua L. The identification of the phenolic profile by HPLC-UV/MS-MS and the study of the antidiabetic effect by in silico, in vitro, and in vivo studies were carried out for extracts with a high content of phenolic compounds from immature wild carob pulp from the communes of Timoulit (TM), Bin Elouidane (AW), and Ouaouizerth (TG) in the province of Azilal in the Beni Mellal-Khenifra region. The results revealed a gradual increase in total sugar content over the pulp's ripening period, reaching a value of 2134 ±56.23 mg GE/100 g fresh matter (FM) for TG. The three locations showed peak values for total polyphenol content (TPC), total flavonoid content (TFC), and total condensed tannin (TCT) at the M2 stage. AW has the highest concentrations of TPC (3819 ± 226.4 mg GAE/100 g FM), TFC (1034 ± 57.08 mg QE/100 g FM), and TCT (1472 ± 28.46 mg CE/100 g FM). The DPPH assay (7892 ± 296.1 mg TE/100 g FM) and the FRAP assay (278.2 ± 7.85 mg TE/100 g FM) both demonstrate that the TG zone is a highly potent antioxidant zone. In contrast, the AW site exhibits a markedly elevated value of 725.4 ± 103.6 mg TE/100 g FM in the ABTS assay. HPLC-UV-MS/MS analysis showed that the methanolic extracts of immature carob pulp (MEICP) from the three areas contained several different chemical compounds. The most prevalent were 3-O-p-coumaroyl-5-O-caffeoylquinic acid, quercetin 3-methyl ether, gallic acid, and galloylquinic acid. Immature carob pulp extract. (ICPE) from AW showed the strongest in vitro inhibition of pancreatic α-amylase (IC50 = 0.405 µg/mL) and TG extracts were most potent against intestinal α-glucosidase (IC50 = 0.063 µg/mL). In vivo, AW, TG, and TM extracts significantly reduced postprandial glycemia in rats, with AW having the greatest effect. These results highlight the antidiabetic potential of ICPE. The 3-O-p-Coumaroyl-5-O-caffeoylquinic acid showed a better affinity for α-amylase compared to acarbose and interacted significantly with several amino acid residues of the enzyme. Similarly, this molecule and 3,4-Dicaffeoylquinic acid demonstrated a strong affinity for α-glucosidase, suggesting their potential as natural inhibitors of enzymes involved in carbohydrate metabolism. Most of the compounds are not substrates of P-glycoprotein and exhibit high intestinal absorption. Furthermore, the majority of these compounds do not act as inhibitors or substrates of CYP450 enzymes, reinforcing their suitability for development as oral medications. These results underscore the potential of immature carob pulp as a promising antidiabetic agent.

Preprint ARTICLE | doi:10.20944/preprints201611.0046.v1

An Analysis of Technical Efficiency for Household’s Rice Production in Cambodia: A Case Study of Three Districts in Battambang Province

Sokvibol Kea, Hua Li, Linvolak Pich

Subject: Business, Economics And Management, Economics Keywords: agricultural productivity; Battambang; Cambodia; rice production; stochastic frontier production function (SFA model); technical efficiency

Online: 8 November 2016 (08:51:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints201610.0135.v1

An Analysis of Technical Efficiency for Household's Rice Production in Cambodia: A Case Study of Three Districts in Battambang Province

Sokvibol Kea, Hua Li, Linvolak Pich

Subject: Business, Economics And Management, Economics Keywords: technical efficiency; stochastic frontier production function (SFA model); rice production; Battambang; Cambodia; agricultural productivity

Online: 31 October 2016 (03:31:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.1745.v1

Early Mediterranean-Based Nutritional Intervention Reduces the Rate of Gestational Diabetes Mellitus in Overweight and Obese Pregnant Women: A Post-Hoc Analysis of the San Carlos Gestational Prevention Study

Rocio Martin-O´Connor, Ana M. Ramos-Leví, Verónica Melero, María Arnoriaga-Rodríguez, Ana Barabash, Johanna Valerio, Laura Del Valle, María Paz De Miguel Novoa, Angel Díiaz, Cristina Familiar, Inmaculada Moraga, Alejandra Durán, Martín Cuesta, Maria Jose Torrejón, Mercedes Martinez-Novillo, Clara Marcuello, Mario Pazos, Miguel Ángel Rubio-Herrera, Pilar Matía-Martín, Alfonso Luis Calle-Pascual

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: obesity; overweight; metabolic syndrome; fasting blood glucose; mediterranean diet

Online: 27 May 2024 (13:30:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0924.v1

In Vitro Investigation Using a New Biomechanical Force-Torque Analysis System: Comparison of Conventional and CAD/CAM Fixed Orthodontic Retainers

Francesca Thaden, Linus Hötzel, Hisham Sabbagh, Matthias Mertmann, Andrea Wichelhaus

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: biomechanics; orthodontics; retainer; inadvertent tooth movements; force; torque

Online: 11 September 2024 (16:41:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1464.v1

Analysis of CDO, PITX2, and CDH13 gene methylation in early endometrial cancer for prediction of medical treatment outcomes

Aleksey M. Krasnyi, Lyubov T. Gadzhieva, Diana N. Kokoeva, Mark G. Kosenko, Ekaterina L. Yarotskaya, Stanislav V. Pavlovich, Levon A. Ashrafyan, Gennady Sukhikh

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: methylation; atypical endometrial hyperplasia; endometrial cancer; organ-preserving treatment; MS-HRM; CDO1; CDH13

Online: 26 February 2024 (14:19:49 CET)

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An observational cohort study of patients diagnosed with endometrial cancer (EC) stage IA G1, or atypical endometrial hyperplasia (AHE), undergoing organ-preserving treatment, was conducted. Objective of the study: to determine CDO1, PITX2, and CDH13 gene methylation levels in early endometrial cancer and atypical hyperplasia specimens obtained before organ-preserving treatment in the patients with adequate response and with insufficient response to hormonal treatment. Materials and methods: 41 endometrial specimens obtained during diagnostic uterine curettage in women with EC (n=28) and AEH (n=13), willing to preserve reproductive function, were studied; 18 specimens of endometrial cancer IA stage G1 from peri- and early postmenopausal women (comparison group) were included in the study. The control group included 18 endometrial specimens from healthy women obtained by diagnostic curettage for missed abortion and/or intrauterine adhesions. Methylation levels were analyzed using the modified MS-HRM method. Results: All 13 women with AEH had complete response (CR) to medical treatment. In the group undergoing organ-preserving treatment for uterine cancer IA stage G1 (n=28), 14 patients had complete response (EC CR group) and 14 had not (non-CR). It was found that all groups had statistically significant differences in CDO1 gene methylation levels with the control group (p<0.001) except for the EC CR group (p=0.21). The p-value of difference between EC CR and EC non-CR groups was <0.001. The differences in PITX2 gene methylation levels between the control and study groups were also significantly different (p<0.001), except for AEH group (p=0.21). For the difference between EC CR and EC non-CR groups, the p-value was 0.43. For CDH13 gene methylation levels, statistically significant differences were found between the control and EC non-CR groups (p<0.001), and the control and EC comparison groups (p=0.005). When comparing the EC CR group with EC non-CR group, the p-value for this gene was <0.001. Simultaneous assessment of CDO1 and CDH13 genes methylation allowed to accurately distinguish between EC CR and EC non-CR groups (AUC=0.96). Conclusion: Assessment of CDO1 and CDH13 gene methylation in endometrial specimens from patients with endometrial cancer (IA stage G1), planned for medical treatment, can predict the treatment outcome.

Preprint ARTICLE | doi:10.20944/preprints202407.1125.v1

Predictive Analysis of Osteoarthritis and Chronic Pancreatitis Comorbidity: Complications and Risk Factors

Iryna Halabitska, Liliia Babinets, Valentyn Oksenych, Oleksandr Kamyshnyi

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: osteoarthritis; chronic pancreatitis; comorbidity; complications; risk factors; predictors.; pancreatitis

Online: 15 July 2024 (10:26:10 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202106.0263.v3

Discharge Plan to Promote Patient Safety and Shared Decision by a Multidisciplinary Team of Healthcare Professionals in a Respiratory Unit

Daniel A. Nnate, David Barber, Ukachukwu O. Abaraogu

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: chronic obstructive; patient discharge; patient care team; personalized care; interdisciplinary health team; patient safety; pulmonary disease; pulmonary medicine

Online: 14 July 2021 (09:58:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0240.v1

Safeguarding Personal-Identifiable Information (PII) after Smartphone Pairing with Connected Vehicle

Jason W Carlton, Hafiz Malik

Subject: Engineering, Transportation Science And Technology Keywords: connected vehicles; connected vehicle architecture; data privacy; data security; infotainment system; personable identifiable information (pii); ride sharing; software; technology; rental vehicles

Online: 3 September 2024 (17:55:23 CEST)

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The integration of connected autonomous vehicles into the transportation system introduces significant enhancements in driving experience and convenience. Yet, it simultaneously raises important concerns regarding the security and privacy of passenger data. As individuals increasingly depend on these connected vehicles, particularly rental cars with advanced infotainment systems, safeguarding their personal information becomes a paramount imperative, presenting significant challenges that must be addressed to maintain user trust and comply with privacy regulations. This paper investigates risks associated with personal information stored in connected vehicle technology, emphasizing the importance of robust security and privacy practices. In the advent of cyber threats and the need for data protection, we examine a risk management framework (RMF) as suggested by NIST, which aims to address these quintessential concerns preemptively. Our research moves beyond the limitations of manual safeguarding methods, supporting the necessity for an advanced automated technical solution. To address these issues, we introduce and meticulously assess the efficacy of “Vehicle Inactive Profile Removal” (VIPR), an innovative technical solution conceived to actively eliminate the risks and potential oversights that stem from the prevalent tendency of renters to leave personal data unerased in the infotainment systems of rented connected vehicles. We provide a thorough evaluation of VIPR through various scenarios, including vehicle return to a rental depot, subsequent rentals, and ridesharing contexts. Our proof of concept includes an array of experiments to demonstrate how VIPR proficiently and autonomously removes previous renters’ “Inactive” profiles from a simulated infotainment system. The results highlight how VIPR constitutes a critical step towards enhancing the privacy and security of personal data, thereby promoting a safer, more responsible use of connected vehicle technology in society.

Preprint ARTICLE | doi:10.20944/preprints202408.1527.v1

Challenging LLMs Beyond Information Retrieval: Reasoning Degradation with Long Context Windows

Natanael Fraga

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Large Language Models; Context Window; Reasoning Ability

Online: 22 August 2024 (05:48:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1564.v1

A Bag-of-Words Approach for Information Extraction from Electricity Invoices

Javier Sánchez, Giovanny A. Cuervo-Londoño

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: electricity invoice; information extraction; semi-structured document; machine learning; support vector machine; random forests; decision tree; logistic regression

Online: 24 May 2024 (09:33:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0851.v1

BWC Confidence‐Building Measures: Increasing BWC Assurance through Transparency & Information Sharing

Matthew Shearer, Christina Potter, Rachel Vahey, Nicholas Munves, Gigi Gronvall

Subject: Social Sciences, Political Science Keywords: Biological and Toxin Weapons Convention; Biological Weapons Convention; BWC; BTWC; biological weapons; verification; compliance; confidence-building measures; confidence building measures; CBM; CBMs; nonproliferation; nonproliferation policy; arms control; disarmament; weapons of mass destruction; WMD; biology

Online: 12 April 2024 (14:33:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0346.v1

Research on Online Review Information Classification Based on Multimodal Deep Learning

Jingnan Liu, Yefang Sun, Yueyi Zhang, Chenyuan Lu

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Deep learning; Multimodality; Online review information; Sentiment analysis

Online: 4 April 2024 (12:58:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.2341.v1

An Innovative Information Hiding Scheme Based on Block-Wise Pixel Reordering

Jui‐Chuan Liu, Hengxiao Chi, Ching-Chun Chang, Chin‐Chen Chang

Subject: Computer Science And Mathematics, Signal Processing Keywords: data hiding; vector quantization; codebook; codeword index reordering

Online: 30 December 2023 (16:30:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0671.v1

Semantic Modelling Approach for Safety-Related Traffic Information using DATEX II

J. Javier Samper-Zapater, Julian Gutiérrez-Moret, Jose Macario Rocha, Juan José Martinez-Durá, Vicente R. Tomás

Subject: Computer Science And Mathematics, Computer Science Keywords: Safety Road Traffic; Semantic web; LOD

Online: 10 November 2023 (07:31:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0660.v1

A Fractional (q, q′) Non-extensive Information Dimension of Complex Networks

Aldo Ramirez-Arellano, Jazmin-Susana De-la-Cruz-Garcia, Juan Bory-Reyes

Subject: Computer Science And Mathematics, Mathematics Keywords: Complex networks; measures of information; fractional order entropy

Online: 11 September 2023 (10:06:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0007.v1

Enhancing Cache Robustness in Information-Centric Networks: Per-Face Popularity Approaches

John Baugh, Jinhua Guo

Subject: Computer Science And Mathematics, Computer Networks And Communications Keywords: Named Data Networking; Information Centric Networking; NDN; ICN; cache pollution; hit rate; popularity; cache robustness

Online: 1 August 2023 (03:48:00 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202306.0863.v1

Research on Information Fusion System Implementation Based on ARM-Based FPGA

Yu-Hsiang Tsai, Yung-Jhe Yan, Meng-Hsin Hsiao, Tzu-Yi Yu, Mang Ou-Yang

Subject: Engineering, Electrical And Electronic Engineering Keywords: augmented reality; information fusion; transparent display

Online: 13 June 2023 (02:56:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0416.v1

Privacy-Aware Cloud Architecture for Collaborative Use of Patients’ Health Information

Fadi Alhaddadin, Jairo Gutierrez

Subject: Computer Science And Mathematics, Computer Networks And Communications Keywords: Cloud Architecture; Data Privacy; Data Confidentiality; Information Sharing; Health Information; Patient Records

Online: 6 May 2023 (10:27:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0160.v1

Biophysical Interactions Underpin the Emergence of Information in the Genetic Code

Aaron Halpern, Lilly R Bartsch, Kaan Ibrahim, Stuart A Harrison, Minkoo Ahn, John Christodoulou, Nick Lane

Subject: Biology And Life Sciences, Life Sciences Keywords: origin of life; genetic code; biophysical interactions; hydrophobicity; anticodon; molecular dynamics; NMR

Online: 10 April 2023 (09:07:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0311.v1

A Dialogue System that Models User's Opinion Based on Information Content

Yoshiki Ohira, Takahisa Uchida, Takashi Minato, Hiroshi Ishiguro

Subject: Computer Science And Mathematics, Computer Science Keywords: opinion model; user modeling; information content; dialogue strategy; dialogue system

Online: 21 September 2022 (02:27:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0020.v1

Digital Transformation Framework for Facility Management based on Building Information Modelling

Adrian August Wildenauer, Josef Basl, Peter Poór

Subject: Engineering, Architecture, Building And Construction Keywords: conceptual framework; Information Modelling; Building Information Modelling (BIM); Facility Management; Smart Buildings; Smart Applications

Online: 1 July 2022 (16:48:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0196.v1

Self-Organized Structuring of Recurrent Neuronal Networks for Reliable Information Transmission

Daniel Miner, Florentin Wörgötter, Christian Tetzlaff, Michael Fauth

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: self-organization; synaptic plasticity; information transfer

Online: 10 May 2021 (14:06:22 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202008.0195.v1

Information Circulation in The Advanced Neural Activities of Central Neural System

Fayang Ma

Subject: Social Sciences, Behavior Sciences Keywords: Information Circulation; Perception; Memory; Consciousness; Neural Circuits

Online: 7 August 2020 (11:47:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0710.v1

Information Theory Optimization Algorithm for Efficient Service Orchestration in Distributed Systems

Matheus Santana Lima

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: traveling salesman problem; information theory; artificial intelligence; computational complex theory; kolmogorov-complexity; kelly criterion and logarithmic utility

Online: 30 July 2020 (09:08:04 CEST)

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Working Paper HYPOTHESIS

Upper Limit on the Thermodynamic Information Content of an Action Potential

Sterling Street

Subject: Biology And Life Sciences, Biophysics Keywords: information; entropy; energy; thermodynamics; Landauer's principle; action potential

Online: 4 February 2020 (04:42:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints201911.0035.v1

Smart Resources for Smart Cities: Distributed Architecture to Integrate Sensor Information

Jose-Luis Poza-Lujan, Juan-Luis Posadas-Yagüe, Jose-Enrique Simó-Ten, Juan Francisco Blanes Noguera

Subject: Engineering, Control And Systems Engineering Keywords: smart environment; smart sensors; distributed architectures; object detection; information integration

Online: 4 November 2019 (03:45:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints201905.0280.v1

Communicating Health Information at the End of Life: The Carers’ Perspective

Olivia Ibañez-Masero, Inés María Carmona-Rega, María Dolores Ruiz-Fernández, Rocío Ortiz-Amo, José Cabrera-Troya, Ángela María Ortega-Galán

Subject: Public Health And Healthcare, Nursing Keywords: information; end of life; humanisation; health care system; qualitative research

Online: 23 May 2019 (06:09:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0015.v1

A Novel Device-Free Counting Method Based on Channel Status Information

Junhuai Li, Pengjia Tu, Huaijun Wang, Kan Wang, Lei Yu

Subject: Computer Science And Mathematics, Computer Science Keywords: wavelet transform; covariance matrix; spatial diversity; frequency diversity; robustness

Online: 1 August 2018 (10:10:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0044.v1

Integrated Modeling Approach for the Development of Climate-Informed, Actionable Information

David R. Judi, Cindy L. Rakowski, Scott R. Waichler, Youcan Feng

Subject: Engineering, Civil Engineering Keywords: climate projections; integrated modeling; flood modeling; nonstationarity

Online: 2 May 2018 (13:15:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201802.0008.v1

Computational Information Geometry For Binary Classification of High-Dimensional Random Tensors

Gia-Thuy Pham, Rémy Boyer, Frank Nielsen

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: Optimal Bayesian detection, information geometry, minimal error probability, Chernoff/Bhattacharyya upper bound, large random tensor, Fisher information, large random sensing matrix

Online: 1 February 2018 (16:32:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints201711.0052.v1

Information Entropy Production of Maximum Entropy Markov Chains from Spike Trains

Rodrigo Cofre, Cesar Maldonado

Subject: Physical Sciences, Thermodynamics Keywords: information entropy production; Discrete Markov Chains; spike train statistics; Gibbs measures; maximum entropy principle

Online: 8 November 2017 (04:25:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints201707.0025.v1

The Regulation of Sustainability Information–The Contribution of Directive 2014/95

Cristian Carini, Laura Rocca, Monica Veneziani, Claudio Teodori

Subject: Business, Economics And Management, Accounting And Taxation Keywords: sustainability reporting; non-financial information; corporate social responsibility; accounting regulation; directive 2014/95; oil & gas

Online: 12 July 2017 (08:50:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201706.0115.v1

Fair: A Hadoop-based Hybrid Model for Faculty Information Retrieval System

Harishchandra Dubey

Subject: Computer Science And Mathematics, Information Systems Keywords: big data,；Hadoop； visualization； model

Online: 26 June 2017 (06:07:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0943.v1

Making Rivers, Producing Futures. The Rise of an Eco‐Modern River Imaginary in Dutch Climate Change Adaptation

Lotte De Jong, Gert Jan Veldwisch, Lieke Anna Melsen, Rutgerd Boelens

Subject: Social Sciences, Political Science Keywords: climate change adaptation; futures; river imaginary; water management; Border Meuse project

Online: 11 January 2024 (14:55:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0321.v1

How to Improve Surveillance Program for Shiga Toxin-Producing E. coli (STEC): Gap Analysis and Pilot Study

Valerio Massimo Sora, Francesca Zaghen, Alfonso Zecconi

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: E. coli; STEC; epidemiology; surveillance; molecular biology; PCR; dairy; bovines.

Online: 3 April 2024 (16:33:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2056.v1

Comparison between Traditional and Innovative NMR Methods for the Analysis of Sicilian Monovarietal Extra Virgin Olive Oils: Metabolic Profile is Influenced by Micro Pedoclimatic Zones

Archimede Rotondo, Giovanni Bartolomeo, Irene Maria Spanò, Giovanna Loredana La Torre, Giuseppe Pellicane, Maria Giovanna Molinu, Nicola Culeeddu

Subject: Chemistry And Materials Science, Food Chemistry Keywords: NMR analysis; MARA‐NMR; extra‐virgin‐olive‐oil; Olea europaea; 13C‐NMR; metabolic profile; PLS‐DA

Online: 25 July 2024 (13:37:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0289.v1

Design and Analysis of a High Gain, Low-Noise and Low-Power Analog Front End for ECG Acquisition in 45nm Technology Using Gm/Id Method

Md. Zubair Alam Emon, Khosru Mohammad Salim, Md. Iqbal Bahar Chowdhury

Subject: Engineering, Electrical And Electronic Engineering Keywords: Operational Trans-conductance Amplifier; Op-amp; ECG; Bio-medical applications; Filter; Low-power CMOS circuits; Gm/Id method; Layout; Parasitic extraction

Online: 6 May 2024 (10:33:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1358.v1

Performance and Stability Analysis of Extra-early Maturing Provitamin A Maize Hybrids under Drought Stress and Well-Watered Conditions

Tégawendé O. Bonkoungou, Baffour Badu-Apraku, Victor O. Adetimirin, Kiswendsida R. Nanema, Idris I. Adejumobi

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: drought tolerance; multiple trait base index; multiple-trait genotype-ideotype distance index; stability; sub-Saharan Africa

Online: 22 March 2024 (06:37:16 CET)

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Maize is an important staple food crop in sub-Saharan Africa (SSA). However, the average grain yield on farmers’ fields falls considerably short of the demand of the region’s population. In addition, the normal endosperm maize widely consumed in SSA is deficient in vitamin A. Drought, a consequence of climate change, is a major constraint to maize production, resulting in seasonal low grain yield in farmers’ fields. The objectives of this study were to assess the performance of newly developed extra-early maturing provitamin A hybrids under managed drought and well-watered conditions, compare the outcomes of multiple trait base-index and multi-trait genotype-ideotype distance index selection procedures, and identify drought-tolerant hybrids with stable performance across contrasting environments for commercialization in SSA. One hundred and ninety provitamin A hybrids and six checks were evaluated under managed drought and well-watered conditions at Ikenne for two seasons between 2021 and 2023. A 14*14-lattice design was used for the field evaluations under both research conditions. Drought stress was achieved by the complete withdrawal of irrigation water 25 days after planting. Results revealed significant differences among the hybrids under drought and well-watered conditions. Grain yield, ears per plant, and plant aspect under managed drought were correlated to the same traits under well-watered conditions suggesting that the expression of these traits is governed by common genetic factors. Twenty-nine hybrids were identified as top-performing drought-tolerant hybrids by the multiple trait base index and multiple-trait genotype–ideotype distance index. Of the selected outstanding 29 hybrids, 34% were derived from crosses involving the tester TZEEIOR 197, demonstrating the outstanding genetic potential of this inbred line. Further analysis of the 29 selected hybrids revealed TZEEIOR 509 × TZEEIOR 197 as the hybrid that combined the most drought-tolerant adaptive traits. However, the hybrids TZEEIOR 526 × TZEEIOR 97, TZEEIOR 384 × TZEEIOR 30, TZEEIOR 515 × TZEEIOR 249, TZEEIOR 510 × TZEEIOR 197, TZEEIOR 479 × TZEEIOR 197, and TZEEIOR 458 × TZEEIOR 197 were identified as the most stable hybrids across drought and well-watered conditions. These hybrids should be extensively tested in multi-location trials for deployment and commercialization in SSA.

Preprint ARTICLE | doi:10.20944/preprints202207.0080.v1

A Density Functional Theory and Information-Theoretic Approach Study of Interaction Energy and Polarizability for Base Pairs and Peptides

Dongbo Zhao, Shubin Liu, Dahua Chen

Subject: Chemistry And Materials Science, Theoretical Chemistry Keywords: density functional theory (DFT); information-theoretic approach (ITA); base pairs; peptides; molecular polarizability

Online: 6 July 2022 (03:04:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1163.v1

Analysis of Resin-Based Dental Materials Composition Depending on Their Clinical Applications

Claire-Adeline Dantagnan, Sylvie Babajko, Ali Nassif, Sophia Houari, Katia Jedeon, Philippe François, Elisabeth Dursun, Jean-Pierre Attal, Julia Bosco

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Bisphenol A; endocrine disruptors; dentistry; resins

Online: 19 March 2024 (16:14:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints201910.0355.v1

Cognitive Fusion Mediates the Relationship between Dispositional Mindfulness and Anxiety and Other Negative Emotions: A Study in a Sample of Spanish Primary-School Students

María García-Gómez, Joan Guerra, Victor M. López-Ramos, José M. Mestre

Subject: Social Sciences, Psychology Keywords: dispositional mindfulness; cognitive defusion; anxiety; mindfulness based on interventions; mental health; experiential avoidance; children and adolescents

Online: 30 October 2019 (10:11:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202207.0441.v1

Knowledge Map of Digital Learning and Sustainable Development (2004-2022): a Scientometric Analysis by Using Citespace

Youhua Shen, Lehui Huang, And Xueshi Wu

Subject: Social Sciences, Education Keywords: digital learning; CiteSpace; visualization; Web of Science

Online: 29 July 2022 (02:48:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1768.v1

Phase Transition Analysis of the Potts-SOS Model with Spin Set {-1,0, 1} on the Cayley Tree

Hasan Akin

Subject: Computer Science And Mathematics, Mathematics Keywords: Potts-SOS model; Gibbs measure; phase transition; stability analysis

Online: 26 August 2024 (03:02:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1163.v1

An Analysis Comparing the Taguchi Method for Optimizing the Process Parameters of AA5083/Silicon Carbide and AA5083/Coal Composites That Are Fabricated via FSP

Oritonda Muribwathoho, Velaphi Msomi, Sipokazi Mabuwa

Subject: Engineering, Mechanical Engineering Keywords: Aluminium alloys; Composite; Metal Matrix Composite; Mechanical Properties; Friction Stir Welding; Friction Stir Processing; Taguchi; S/N Ratio; ANOVA

Online: 16 September 2024 (10:00:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2151.v1

Comprehensive Analysis of the Image of Group Fitness Instructors: Intra- and Inter-Country Comparison between Portugal and Romania

Viorel Petru Ardelean, Vlad Adrian Geantă, Corina Dulceanu, Claudiu Bulzan, Guilherme Eustáquio Furtado, Ricardo Gomes, Fernando Martins, Francisco Campos

Subject: Social Sciences, Education Keywords: fitness instructor; fitness industry; physical fitness

Online: 26 July 2024 (10:15:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1028.v1

Making more with Less: Improving Software Testing Outcomes Using a Cross-Project and Cross-Language ML Classifier Based on Cost-Sensitive Training

Alexandre Moreira Nascimento, Gabriel Kenji Godoy Shimanuki, Luiz Alberto Vieira Dias

Subject: Engineering, Safety, Risk, Reliability And Quality Keywords: Machine Learning; Imbalance; Software Defect Prediction; NASA MDP; Random Forest; Software Quality; Generalization; Cost-Sensitive; Cross-language; Cross-Project

Online: 16 May 2024 (08:17:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0702.v1

Comparative Analysis on the Mechanical Properties, Transportation Cost, and Carbon Footprint Emission of Cement Mortar with PE and SSRS as Partial Replacement for Aggregates

Shen-Lun Tsai, Her-Yung Wang, Keng-Ta Lin, Chang-Chi Hung

Subject: Engineering, Civil Engineering Keywords: cement mortar; PE; SSRS; sustainable material; recycling

Online: 10 April 2024 (13:16:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1190.v1

The Use of Academic Library and Information Seeking Behavior of Students at Lusaka Apex Medical University

Dalitso Mvula

Subject: Social Sciences, Library And Information Sciences Keywords: Information seeking; behaviour; library

Online: 16 August 2024 (09:43:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0521.v1

Comparative study between the energy information system and the energy management system according to ISO 50001

Séraphin Ebagninin KOUAHO, Yao N'GUESSAN, Christophe MARVILLET

Subject: Engineering, Energy And Fuel Technology Keywords: “Energy Information System”, “ISO 50001”, “Energy Management System”, Energy

Online: 9 May 2024 (00:38:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1827.v1

A Theory of Everything: When Information Geometry Meets the Generalized Brownian Motion and the Einsteinian Relativity

Dr Ismail A Mageed

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: Generalized Brownian Motion (GBM), probability density function (PDF),matrix exponential of A (geodesic equations (GEs).

Online: 25 January 2024 (14:10:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1720.v1

Exposure to Climate Change Information on Affect and Pro‐Environmental Behavioural Intentions: A Randomised Controlled Trial

Samantha Greaves, Caroline Harvey, Yashuhiro Kotera

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: climate change; positive and negative affect; pro-environmental behavioural intentions; climate anxiety

Online: 28 November 2023 (08:15:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.2027.v1

Fault Recovery Methods for a Converged System Comprised of Power Grids, Transportation Networks and Information Networks

Geng Zhang, Chenxu Liu, Hao Jiang, Jiye Wang

Subject: Engineering, Electrical And Electronic Engineering Keywords: triple-network convergence; fault recovery; TD3 algorithm; DoS attack; resilience

Online: 29 September 2023 (08:35:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1967.v1

A Multi-Scale Object Detector Based on Coordinate and Global Information Aggregation for UAV Aerial Images

Liming Zhou, Zhehao Liu, Hang Zhao, Yan-e Hou, Yang Liu, Xianyu Zuo, Lanxue Dang

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: UAV images; multi-feature fusion; information aggregation; multi-scale object detection

Online: 29 May 2023 (04:52:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0374.v1

ESarDet: An Efficient SAR Ship Detection Method Based on Context Information and Large Effective Receptive Field

Yimin Zhang, Chuxuan Chen, Ronglin Hu, Yongtao Yu

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: ship detection; synthetic aperture radar (SAR); context information; effective receptive field; you only look once (YOLO)

Online: 6 May 2023 (04:17:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0288.v1

COVID-19 and Health Information Seeking Behavior: Digital Health Literacy Survey Amongst University Students in Pakistan

Rubeena Zakar, Sarosh Iqbal, Muhammad Zakria Zakar, Florian Fischer

Subject: Business, Economics And Management, Accounting And Taxation Keywords: eHealth Literacy; digital health literacy; sense of coherence; COVID-19; COVID-HL-Q; Pakistan.

Online: 10 March 2021 (15:07:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0225.v1

Adoption of ICT-based Information Sources and Market Participation among Smallholder Livestock Farmers in South Africa

Christopher Ugochukwu Nwafor, Abiodun, A. Ogundeji, Carlu van der Westhuizen

Subject: Computer Science And Mathematics, Information Systems Keywords: double hurdle; ICTs; market participation; information source; probit; regression model; smallholder farmer; livestock

Online: 17 December 2019 (09:59:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints201905.0314.v1

The Scientific Information Model of Chang’e-4 Visible and Near-IR Imaging Spectrometer(VNIS) and In-Orbit Verification

Chunlai Li, Zhendong Wang, Rui Xu, Gang Lv, Liyin Yuan, Zhiping He, Jianyu Wang

Subject: Environmental And Earth Sciences, Space And Planetary Science Keywords: the Chang’e-4 lunar rover; phase-locked; signal-to-noise ratio; spectral resolution; infrared focal plane components

Online: 27 May 2019 (12:01:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1314.v1

Households’ Financial Literacy in Central European Countries – a Recent Survey in Poland

Łukasz Gębski, Georges Daw

Subject: Business, Economics And Management, Finance Keywords: Financial literacy; behavioral finance; consumers' cognitive errors; responsible lending and borrowing.

Online: 19 June 2024 (11:01:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1844.v1

Understanding the Influence of Digital Technology on Human Cognitive Processes: A Review

Eugénia Barros

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: cognitive functions; information processing; digital technology; neuroplasticity, executive functions; digital media

Online: 28 April 2024 (10:26:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0590.v1

Examining The Effects of Carbon Dioxide Emissions on Human Brain Activity Using Agent-Based Modeling

Areej Alqarni, Alyaa Almarwaey

Subject: Environmental And Earth Sciences, Pollution Keywords: Carbon Dioxide; Agent Based Modeling; Cognitive Function; Neurophysiological Processes

Online: 14 March 2024 (05:51:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1447.v1

Cognitive Profiles of Partial PTSD in Vietnam War Veterans

Jihye Song, Hyung Seok So, Jin Hee Choi, Hayun Choi, Seung-Hoon Lee

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: posttraumatic stress disorder; psychological Trauma; cognitive function; neurocognitive tests; veteran health

Online: 26 February 2024 (12:42:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0142.v1

Seeing the Error in my “Bayes”: A Quantified Degree of Belief Change Correlates with Children's Pupillary Surprise Responses Following Explicit Predictions

Joseph Colantonio, Igor Bascandziev, Maria Theobald, Garvin Brod, Elizabeth Bonawitz

Subject: Social Sciences, Cognitive Science Keywords: Bayesian Inference; Cognitive Development; Learning; Prediction; Pupil Dilation; Science Learning; Surprise

Online: 8 November 2022 (03:10:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0439.v1

An fNIRS Study of Applicability of The Unity-Diversity Model of Executive Functions in Preschoolers

Sha Xie, Chaohui Gong, Jiahao Lu, Hao Zhang, Dandan Wu, Xinli Chi, Hui Li, Chunqi Chang

Subject: Social Sciences, Behavior Sciences Keywords: executive function; early childhood; fNIRS; working memory; cognitive shifting; inhibitory control

Online: 28 October 2022 (07:02:39 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202103.0698.v1

A call for Linguistic Awareness in the Age of Pandemic: a Brief study of a Misleading Term in a Trending Covid19- Related Article in Nature Human Behavior

soheil daneshzadeh

Subject: Social Sciences, Anthropology Keywords: Small gatherings cancellation; Cognitive linguistics; Corpus analysis; Semantic frame; Covid-19.

Online: 29 March 2021 (14:41:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201910.0115.v1

SCATTER PHY: An Open Source Physical Layer for the DARPA Spectrum Collaboration Challenge

Felipe Augusto Pereira de Figueiredo, Dragoslav Stojadinovic, Prasanthi Maddala, Ruben Mennes, Irfan Jabandžic, Xianjun Jiao, Ingrid Moerman

Subject: Engineering, Electrical And Electronic Engineering Keywords: cognitive radios; Collaborative Intelligent Radio Networks; spectrum sharing; coexistence; experimental evaluation

Online: 10 October 2019 (09:37:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201610.0032.v1

Spectrum-Availability Based Routing for Cognitive Sensor Networks

Lichen Zhang, Zhipeng Cai, Peng Li, Xiaoming Wang

Subject: Computer Science And Mathematics, Computer Networks And Communications Keywords: internet of thing; IoT; cognitive sensor networks; forwarding; spectrum-availability; retransmission

Online: 10 October 2016 (12:17:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1954.v1

An Assessment of Semaglutide Safety Based on Real World Data: From Popularity to Spontaneous Reporting in EudraVigilance Database

Anca Butuca, Carmen Maximiliana Dobrea, Anca Maria Arseniu, Adina Frum, Adriana Aurelia Chis, Luca Liviu Rus, Steliana Ghibu, Anca Maria Juncan, Andrei Catalin Muntean, Antonina Evelina Lazăr, Felicia Gabriela Gligor, Claudiu Morgovan, Andreea Loredana Vonica-Tincu

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: semaglutide; obesity; weight loss; overdose; underdose; off-label use; EudraVigilance; GLP-1

Online: 30 April 2024 (10:14:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0208.v1

Reviving the Past for a Healthier Future: Ancient Molecules and Remedies as a Solution to the Antibiotic Crisis

Miguel Angel Díaz-Guerrero, Israel Castillo-Juárez, Rimma Zurabian, Alejandra Valdez, Kokila Kota, Yuki Hoshiko, Ekaprana Ramesh, Mariano Martínez Vazquez, Corina Diana Ceapă, Mariel Hernandez-Garnica, Frederic Cadet, Rodolfo García Contreras

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: ancientbiotics; antimicrobial resistance; superbug solutions ;

Online: 6 May 2024 (08:17:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0912.v2

Comparative Analysis of Rapid and Less Invasive Methods for A2A2 Dairy Cattle Genotyping and A2 Milk Purity Detection

Leandra Oliveira Xavier Albiero, Rafaela Ansiliero, Aniela Pinto Kempka

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: A2A2 dairy cows; Genotyping; ELISA; LFIA; Comparison of methods; Facilitated analysis

Online: 14 August 2024 (11:56:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0791.v1

Frequency-Based Flood Risk Assessment and Mapping of a Densely Populated Kano City in Sub-Saharan Africa using MOVE Framework

Ali Aldrees, Abdulrasheed Mohammed, Salisu Dan’azumi, Sani Isah Abba

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Flood hazard; Social vulnerability; Flood risk; Flood mapping; Kano metropolis

Online: 14 February 2024 (09:12:44 CET)

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Preprint REVIEW | doi:10.20944/preprints202407.1630.v1

Ticks as Vectors of Trypanosomatidae with Medical or Veterinary Interest: Insights and Implications from a Comprehensive Systematic Review and Meta-Analysis

Tahar KERNIF, Bachir MEDROUH, Naouel EDDAIKRA, Bruno OURY, Philippe HOLZMULLER, Denis SERENO

Subject: Biology And Life Sciences, Parasitology Keywords: Trypanosomatidae; Trypanosoma; Leishmania; Ticks; Ixodidae; Argasidae; vector borne disease

Online: 19 July 2024 (14:55:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0699.v1

Assessment of Cassava Pollen Viability and Ovule Fertilizability under Red-Light and Plant-Growth-Regulator Treatments

Julius K. Baguma, Settumba B. Mukasa, Mildred Ochwo-Ssemakula, Ephraim Nuwamanya, Paula Iragaba, Enoch Wembabazi, Michael Kanaabi, Peter T Hyde, Tim L Setter, Titus Alicai, Benard Yada, Williams Esuma, Yona Baguma, Robert S. Kawuki

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: pollen viability; in vitro stainability; in vivo germinability; ovule fertilizability; pollen diameter; pollen ploidy

Online: 11 June 2024 (12:00:37 CEST)

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Understanding pollen and ovule fertility as factors influencing fruit and seed set is important in cassava breeding. Red light (RL) and plant growth regulators (PGRs) have been used to induce or enhance flowering and fruit set in cassava without any reference to effects on pollen viability or ovule fertilizability. This study investigated effects of field-applied RL and PGR on pollen viability and ovule fertilizability. Panels of cassava genotypes, with early or moderate flowering responses were used. RL was administered from dusk to dawn. Two PGRs, a cytokinin (6-benzyl adenine, BA) and an anti‑ethylene (silver thiosulphate, STS) were applied. Pollen viability was assessed basing on pollen grain diameter, in vitro stainability, in vivo germinability, ovule fertilizability and ploidy level. Treating flowers with RL led to increased pollen diameter from 143.6 to 148.5µm, stainability from 82.9 to 93.0%, ovule fertilizability from 52.0 to 56.9% in treated female flowers and 47.7 to 64.3% on using pollen from treated male flowers. Fruit set increased from 51.5 to 71.8% in RL-treated female flowers and from 53.7 to 71.1% when pollen from RL-treated male flowers was used. Seed set followed a trend similar to that of fruit set. Ploidy level of pollen from RL-treated flowers increased slightly and positively correlated with pollen diameter (R2 = 0.09*), ovule fertilization (R2 = 0.20*), fruit (R2 = 0.59*) and seed set (R2 = 0.60*); but negatively correlated with pollen stainability. Treating flowers with PGR did not affect pollen diameter and stainability, but increased ovule fertilizability from 42.9 to 64.9% and fruit set from 23.2 to 51.9% in treated female flowers and 31.3 to 54.7% when pollen from treated male flowers was used. Application of combined BA+STS on male flowers caused the highest ovule fertilizability, fruit and seed set efficiency, though this varied among study genotypes. These results show that RL and PGR treatment of flowers increases pollen viability and ovule fertilizability. This is important for planning pollination strategies in cassava breeding programmes.

Preprint ARTICLE | doi:10.20944/preprints201906.0028.v1

A General Theory of Autoimmune Disease Causation: Integrating Innate and Adaptive Immunity, Altered Antigen Processing, Sex and Genetic Predispositions, and Microbiome Effects

Robert Root-Bernstein

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: autoimmunity; toll-like receptors; TLR; nucleotide-binding oligomerization domain; NOD1; major histocompatibility complex; MHC; human leukocyte antigens; HLA; proteasome; innate immunity; adaptive immunity; T cells; B cells; antibodies; microbiome; tolerance; self; non-self; antigen processing

Online: 4 June 2019 (10:21:32 CEST)

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Current theories of autoimmunity are diverse, sometimes contradictory, and suffer from incompleteness. Although substantial evidence exists that adaptive and innate immunity, sex, genetic predisposition, and the microbiome all play essential roles in autoimmune disease etiologies and pathogenesis, and that antigen processing is altered during disease induction, no existing theory integrates all of these factors through a single, coherent mechanism. In an attempt to focus the field on the need to elucidate such an integrative mechanism, I propose one possibility here that, if nothing else, helps to identify the nature of the problems that need to be addressed. My theory is that autoimmune diseases are induced by normal immunological responses to unique pairs of complementary antigens, at least one of which is a molecular mimic of a host target. Each antigen in the complementary pair induces a complementary immune response (T or B cell); although each immune response is idiotypic in origin, the antigenic complementarity results in what appears to be an idiotype-anti-idiotype relationship between the responses. Additionally, because of the antigenic complementarity, each immune response mimics one of antigens, abrogating the distinction between self and non-self. If at least one of the antigens mimics a host antigen, then the resulting immunological civil war spreads to a host tissue. Complementary antigens also alter antigen processing so that antigens that would normally be proteolytically digested are presented by the major histocompatibility complex (MHC) to T and B cell receptors inducing a cross-reactive immune response. The resulting civil war is supported by the innate immune system due to the complementarity of the initiating antigens.. Complementary antigens stimulate synergistic toll-like receptors (TLR) and/or nucleotide-binding oligomerization receptors (NOD) resulting in up-regulation of cytokine production and further stimulation of the adaptive immune response. Because the immune responses (e.g., antibodies) mimic the initiating antigens, this synergistic activation of innate immunity becomes chronic. Additionally, TLR and NOD function are highly sensitive to sex hormones, some becoming up-regulated and some down-regulated in the presence of either testosterone or estrogens. This sensitivity explains how sex modifies susceptibility to autoimmune diseases. Genetic mutations in TLR, NOD and MHC further alter antigen presentation and the degree to which antigens stimulate an immune response explaining how genetics also modifies susceptibility. Finally, sex hormones also alter the host microbiome, which in turn modulates autoimmune disease risk by shaping the immunological nature of self and by mediating susceptibility to microbial infection. Moreover, it appears that the microbiome camouflages itself from the immune system by mimicking the host antigenic repertoire; the mimicry between the antigens of the microbiome and the host results in selective attacks on microbiome constituents concomitant with any autoimmune attack on host tissues. This antigenic complementarity theory thereby integrates all major elements known to affect, or be affected by, autoimmune diseases and provides a set of testable implications.

Preprint ARTICLE | doi:10.20944/preprints202407.2027.v1

A New Air Assisted Flare Tip Design for Managing Gas Flare Emissions (CFD Analysis)

Ahmed A Maaroof, Joseph D Smith, Mohammed H S Zangana

Subject: Engineering, Chemical Engineering Keywords: CFD; Gas Flare; Soot Emissions; CE; DRE

Online: 26 July 2024 (04:26:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0494.v1

Central Difference Variational Filtering Based on Conjugate Gradient Method for Distributed Imaging Application

Wen Ye, Fubo Zhang, Hongmei Chen

Subject: Engineering, Aerospace Engineering Keywords: Central difference Kalman filtering; Variational optimization; Conjugate gradient; Airborne distributed position and orientation system

Online: 7 June 2024 (14:37:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201609.0061.v1

A Satellite View of the Atmospheric Dry Intrusion and its Influences on the Mid-Latitude Disastrous Weather

Yi-xuan Shou, Feng Lu, Shaowen Shou

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: dry intrusion; Stratosphere-troposphere exchange; mid-latitude; satellite

Online: 18 September 2016 (10:27:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.1282.v1

Enigma of Pyramidal Neurons:Chirality-Centric View on Biological Evolution. Congruence to Molecular, Cellular, Physiological, Cognitive and Psychological Function

Victor Vasilyevich Dyakin, Nika Victorovna Dyakina-Fagnano

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Artificial Intelligence; Bilaterality; Biochirality; Biological Intelligence; Prevalent Molecular Chirality; Pyramidal Neuron; Evolution; Biopsychology; Cognitive Psychology

Online: 18 December 2023 (12:34:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.0788.v1

Physical Vulnerability and Landslide Risk Assessment in Tegucigalpa City, Honduras

Ginés Suárez, María José Domínguez-Cuesta

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: Numerical methods and its applications; reliability and risk analysis; landslide susceptibility modeling and mapping

Online: 12 August 2024 (12:30:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0682.v1

Risk Assessment and Response Strategy for Pig Epidemics in China

Zizhong Shi, Junru Li, Xiangdong Hu

Subject: Business, Economics And Management, Economics Keywords: pig; animal disease; African swine fever; risk assessment; policy recommendations

Online: 10 May 2023 (04:12:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0059.v1

Endo-exoglucanase Synergism for Cellulose Nanofibril Production Assessment and Characterization

Ricardo G. Ramírez Brenes, Lívia da Silva Chaves, Ninoska Bojorge, Nei Pereira Jr.

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: nanocellulose; enzymatic synergism; optimal mixture; CCRD; Colby factor

Online: 5 December 2022 (06:03:10 CET)

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Preprint REVIEW | doi:10.20944/preprints202206.0284.v1

Building Consensus around the Assessment and Interpretation of Symbiodiniaceae Diversity

Sarah Davies, Matthew H. Gamache, Lauren I. Howe-Kerr, Nicola G. Kriefall, Andrew C. Baker, Anastazia T. Banaszak, Line K. Bay, Anthony J. Bellantuono, Debashish Bhattacharya, Cheong Xin Chan, Danielle C. Claar, Mary Alice Coffroth, Ross Cunning, Simon K. Davy, Javier del Campo, Erika M. Diaz-Almeyda, Jorg C. Frommlet, Lauren E. Fuess, Raul A. Gonzalez-Pech, Tamar L. Goulet, Kenneth D. Hoadley, Emily J. Howells, Benjamin C. C. Hume, Dustin W. Kemp, Carly, D. Kenkel, Sheila A. Kitchen, Todd C. LaJeunesse, Senjie Lin, Shelby McIlroy, Ryan McMinds, Matthew R. Nitschke, Clinton A. Oakley, Raquel S. Peixoto, Carlos Prada, Hollie M. Putnam, Kate Quigley, Hannah G. Reich, James Davis Reimer, Mauricio Rodriguez-Lanetty, Stephanie Rosalas, Osama S. Saad, Eugenia M. Sampayo, Scott Santos, Eiichi Shoguchi, Edward G. Smith, Michael Stat, Timothy G. Stephens, Marie E. Strader, David J. Suggett, Timothy D. Swain, Cawa Tran, Nikki Traylor-Knowles, Christian R. Voolstra, Mark E. Warner, Virginia M. Weis, Rachel Wright, Tingting Xiang, Hiroshi Yamashita, Maren Ziegler, Adrienne M.S. Correa, John Everett Parkinson

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Symbiodinaceae; genetic diversity; coral symbiosis

Online: 21 June 2022 (04:49:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0111.v1

Beam Damage Assessment Using Natural Frequency Shift and Machine Learning

Nicoleta Gillich, Cristian Tufisi, Christian Sacarea, Catalin V Rusu, Gilbert-Rainer Gillich, Zeno-Iosif Praisach, Mario Ardeljan

Subject: Engineering, Mechanical Engineering Keywords: damage detection; linear regression; random forest; artificial neural network; training parameters; natural frequency

Online: 10 January 2022 (12:26:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0715.v1

Assessment and Characterization of Reed Canary Grass Plantations for Energy

Blas Mola-Yudego, Xiaoqian Xu, Oskar Englund, Ioannis Dimitriou

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: energy crops; land use; biomass; bioenergy

Online: 27 April 2021 (12:38:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0257.v1

Trace Gas Retrieval from AIUS：Algorithm Description and O₃ Retrieval Assessment

Xiaoying Li, Tianhai Cheng, Jian Xu, Hailiang Shi, Xingying Zhang, Shule Ge, Mingmin Zou, Hongmei Wang, Yapeng Wang, Songyan Zhu, Jing Miao

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: AIUS; occultation; retrieval algorithm; microwindows; ozone

Online: 20 April 2018 (03:59:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2040.v1

Is Complaining Always a Problem? An Exploratory Analysis of Communications Sent by Users to a Public Healthcare Agency

Claudia Venuleo, Tiziana Marinaci, Camilla Cucugliato, Sonia Giausa

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: health services; users’ subjective experience; complaints; appreciations

Online: 25 July 2024 (12:21:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0978.v1

Impact of the COVID-19 Prioritization Recommendations on Pathological Stages of Urologic Malignancies. A Real-World Analysis at a High-Volume Referral Institution

Antonio Andrea Grosso, Riccardo Campi, Fabrizio Di Maida, Alessio Pecoraro, Francesco Lupo Conte, Vincenzo Cangemi, Rossella Catanzaro, Neliana Kucuku, Nassima Doumit, Andrea Mari, Lorenzo Masieri, Sergio Serni, Andrea Minervini

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Oncology; COVID-19; Pandemic; Healthcare

Online: 12 September 2024 (11:38:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1272.v1

A Structural Path Analysis Towards Examining Technological Factors Influencing SME’S Sustainability Through Social Media Marketing

Rasheedul Haque, Abdul Rahman bin S Senathirajah, Md Ibrahim Khalil, Sayeeduz Zafar Qazi, Saif Ahmed

Subject: Business, Economics And Management, Marketing Keywords: SMEs; Social Media Marketing; Sustainability; E-business technology

Online: 20 May 2024 (12:27:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1570.v1

Comparative Analysis of Biofilm Removal Efficiency and Tooth Wear between Mechanical Electric and Bioelectric Devices

Jihyun Lee, Hyun M. Park, Young Wook Kim

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Bioelectric effect; oral health; plaque formation; plaque removal; tooth wear; gingival index

Online: 26 March 2024 (10:28:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.1873.v1

Correlation Between IgA Levels in Henoch–Schönlein Purpura and a Medical History of Infectious Disease in the Pediatric Population: A Five-Year Retrospective Analysis

Sînziana Oprițescu, Gabriela Viorela Nițescu, Mihaela Golumbeanu, Dora Boghițoiu, Elena Iuliana Ioniță, Diana-Andreea Ușurelu, Cristian Lucaci, Adriana Negoiță, Elena Moroșan

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Henoch–Schönlein purpura; IgA vasculitis; allergic vasculitis; infectious diseases

Online: 24 September 2024 (11:57:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.2071.v1

Association between ADIPOQ Gene Polymorphisms and Diabetic Retinopathy Risk: A Systematic Review and Meta-Analysis

Konstantinos Flindris, Georgios Markozannes, Marilita Moschos, Maria Gazouli, Aikaterini Christodoulou, Konstantinos Tsilidis, George Kitsos

Subject: Medicine And Pharmacology, Ophthalmology Keywords: Diabetic retinopathy; Adiponectin gene; ADIPOQ gene; rs2241766; rs1501299

Online: 29 June 2024 (00:20:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0332.v1

Did Cognitive–Attentional Syndrome Symptoms Predict Stress and Trauma-Related Symptoms in the Initial Phase of COVID-19 Pandemic? Results from a Two-Wave Study on a Sample of Polish Internet Users

Małgorzata Dragan, Piotr Grajewski

Subject: Social Sciences, Psychology Keywords: Cognitive–Attentional Syndrome; COVID-19 pandemic; stress and trauma related disorders; psychopathology; adjustment disorder

Online: 5 June 2023 (14:21:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1044.v1

Vitamin D Supply of Twins during Fetal Life, Its Relation to Anthropometric Parameters of Newborns and the Analysis of Other Factors Related to Birth Size

Regina Ewa Wierzejska, Barbara Wojda, Dorota Bomba-Opoń, Iga Rzucidło-Szymańska, Robert Brawura-Biskupski-Samaha, Iwona Szymusik

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: vitamin D concentration; twin pregnancy; umbilical cord blood; neonatal parameters

Online: 13 September 2024 (11:37:33 CEST)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202409.0315.v1

Imaging Techniques for the Analysis of Blood-Brain Barrier and Gliovascular Unit Dysfunction

Samantha Golf, Carmen Munoz-Ballester, Benjamin Heithoff, Kijana George, Stefanie Robel

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Blood-Brain Barrier; BBB; Impairment; Tight Junctions; Astrocyte Endfeet; Endothelial Cells; Basement Membrane

Online: 4 September 2024 (08:33:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0012.v1

Residue from the Passion Fruit Processing Industry: Application of Mathematical Drying Models for Seeds

Mario Eduardo R. Moreira Cavalcanti-Mata, Maria Elita Martins Duarte, Francisco de Assis Mendes, Manoel Tolentino Leite Filho, Rafaela Duarte Almeida, Anna Sylvia R. R. M. Cavalcanti, Renata Duarte Almeida

Subject: Engineering, Bioengineering Keywords: Passiflora edulis f. flavicarpa, fatty acids, physicochemical characteristics, flour production, oil Extraction, drying.

Online: 1 July 2024 (11:02:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0442.v1

Intelligent Petroleum Processing: A Short Review on Applying AI/ML to Petroleum Products Optimization

Abdallah Alzahawy, Hayder Issa

Subject: Engineering, Chemical Engineering Keywords: Intelligent petroleum processing; petroleum products optimization; machine learning techniques; gasoline property prediction; process control and operational efficiency

Online: 5 April 2024 (13:18:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0518.v1

Comparative Metabolomics Reveals Changes in Secondary Metabolites during the Processing of Polygonatum cyrtonema Rhizome

Jianjun Shen, Weiting Pu, Qiyan Song, Bihua Ye, Xiaoxiao Shi, Youwu Chen, Yefei Yu, Haibo Li

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Polygonatum cyrtonema; medicinal plant; processing; secondary metabolites; functional components; metabolomics

Online: 8 January 2024 (11:16:24 CET)

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