REVIEW
|
doi:10.20944/preprints202108.0037.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
ovarian cancer; checkpoint inhibitors; ICIs; immunotherapy; PARP; avelumab; pembrolizumab; nivolumab; bevacizumab; platinum
Online: 2 August 2021 (13:01:35 CEST)
ARTICLE
|
doi:10.20944/preprints202011.0395.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
TNBC; Ca2+-ATPase; SICE; HDAC inhibitors; EMT; WNT signaling; vorinostat; romidepsin; vimentin
Online: 13 November 2020 (20:50:48 CET)
ARTICLE
|
doi:10.20944/preprints202007.0221.v1
Subject:
Chemistry And Materials Science,
Food Chemistry
Keywords:
hCA IX and XII; dual inhibitors; molecular modeling studies; in vitro assays
Online: 11 July 2020 (02:30:03 CEST)
REVIEW
|
doi:10.20944/preprints201909.0140.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
hepatocellular carcinoma; immune checkpoint inhibitors; HCC; pembrolizumab; nivolumab; immune microenvironment; targeted therapies
Online: 14 September 2019 (18:37:29 CEST)
REVIEW
|
doi:10.20944/preprints202406.0880.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Dendritic cells; DC based cancer vaccine; Immune checkpoint inhibitors; Cancer Therapy; Combinatorial therapy
Online: 13 June 2024 (11:51:42 CEST)
REVIEW
|
doi:10.20944/preprints202406.0356.v1
Subject:
Medicine And Pharmacology,
Gastroenterology And Hepatology
Keywords:
liver transplantation; hepatocellular carcinoma; Immune checkpoint inhibitors; allograft rejection
Online: 6 June 2024 (07:45:00 CEST)
ARTICLE
|
doi:10.20944/preprints202405.1174.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Gastric cancer; Proto-Oncogene Protein c-met; Tyrosine Kinase Inhibitors; Cell Line; Tumor
Online: 17 May 2024 (12:28:09 CEST)
REVIEW
|
doi:10.20944/preprints202403.0902.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
NSCLC; lung cancer; gut microbiota; immunotherapy; immune checkpoint inhibitors
Online: 15 March 2024 (07:33:31 CET)
ARTICLE
|
doi:10.20944/preprints202403.0717.v1
Subject:
Biology And Life Sciences,
Animal Science, Veterinary Science And Zoology
Keywords:
Lumpy skin disease; DNA polymerase; potential inhibitors; phytocompounds; antiviral drug compounds; molecular docking
Online: 13 March 2024 (07:58:39 CET)
ARTICLE
|
doi:10.20944/preprints202310.0751.v1
Subject:
Biology And Life Sciences,
Cell And Developmental Biology
Keywords:
Drosophila; male meiosis; cyclin B; Cyclin-dependent kinase 1; Cyclin-dependent kinase inhibitors
Online: 12 October 2023 (05:32:28 CEST)
ARTICLE
|
doi:10.20944/preprints202307.1154.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Uterine fibroids; BRD9 inhibitors; Cell proliferation; Extracellular Matrix; Transcriptome; Epigenome; m6A regulators; Epitranscriptome
Online: 18 July 2023 (04:30:08 CEST)
ARTICLE
|
doi:10.20944/preprints202307.0161.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
Non-small cell lung cancer; Targeted Gene Therapy; Immune Checkpoint Inhibitors; Machine Learning
Online: 4 July 2023 (07:57:03 CEST)
SHORT NOTE
|
doi:10.20944/preprints202212.0230.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
monoamine oxidase; inhibitors; indole; 1,2,4-oxadiazole; drug research; neuroprotective drugs; Parkinson’s disease; MAO
Online: 13 December 2022 (07:12:01 CET)
CASE REPORT
|
doi:10.20944/preprints202201.0298.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Checkpoint inhibitors; Immune related adverse events; Cholestasis; Severe ductopenia; Vanishing bile duct syndrome
Online: 20 January 2022 (11:07:21 CET)
ARTICLE
|
doi:10.20944/preprints202109.0375.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
HIV-protease inhibitors; pseudo-symmetric core; heteroaryl carboxyamides; synthesis; biological screening; molecular modeling
Online: 22 September 2021 (10:44:16 CEST)
REVIEW
|
doi:10.20944/preprints202105.0430.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
ethylene biosynthesis; ethylene inhibitors; in vitro culture; plant hormones; S-adenosylmethionine; stress responses
Online: 19 May 2021 (07:50:29 CEST)
ARTICLE
|
doi:10.20944/preprints202011.0292.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Alzheimer's disease; BACE1; Molecular dynamics; MM/GBSA; Inhibitors; Drug likeness; Ligand efficiency, Kd.
Online: 10 November 2020 (09:10:50 CET)
ARTICLE
|
doi:10.20944/preprints202010.0032.v1
Subject:
Chemistry And Materials Science,
Biomaterials
Keywords:
Nanomedicine; human ferritin; gastrointestinal tumors; non-camptothecin topoisomerase I inhibitors; drug-delivery; CD71
Online: 2 October 2020 (09:21:53 CEST)
ARTICLE
|
doi:10.20944/preprints202004.0439.v1
Subject:
Biology And Life Sciences,
Biophysics
Keywords:
SARS-CoV-2; COVID-19; spike glycoprotein; variability; molecular docking; molecular dynamics; inhibitors
Online: 24 April 2020 (11:42:01 CEST)
REVIEW
|
doi:10.20944/preprints201910.0255.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
antimicrobial resistance; biofilm; efflux pump inhibitors; antibiotic potentiation; eskapee pathogens; gram-negative bacteria
Online: 22 October 2019 (10:22:56 CEST)
ARTICLE
|
doi:10.20944/preprints201812.0362.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
Antibiotic resistance, efflux pump inhibitors, Escherichia coli, efflux pumps, multidrug resistance, Staphylococcus aureus
Online: 31 December 2018 (09:55:32 CET)
REVIEW
|
doi:10.20944/preprints202407.1534.v1
Subject:
Medicine And Pharmacology,
Hematology
Keywords:
lymphoma; B‐cell; hematologic neoplasms; bruton tyrosine kinase; protein kinase inhibitors; drug resistance; neoplasm; ibrutinib; pirtobrutinib; molecular targeted therapy; chronic lymphocytic leukemia; hematopoietic stem cell transplantation; covalent inhibitors; protein degradation
Online: 18 July 2024 (17:24:05 CEST)
ARTICLE
|
doi:10.20944/preprints202408.1642.v1
Subject:
Medicine And Pharmacology,
Hematology
Keywords:
allogeneic hematopoietic stem cell transplantation; chronic myeloid leukaemia; tyrosine kinase inhibitors; imatinib; dasatinib; nilotinib
Online: 22 August 2024 (16:30:22 CEST)
ARTICLE
|
doi:10.20944/preprints202403.1433.v1
Subject:
Computer Science And Mathematics,
Artificial Intelligence And Machine Learning
Keywords:
FLT3 Inhibitors; Ligand-based Drug Design; Computer-Aided Drug Design; QSAR Modeling; AML Treatment
Online: 25 March 2024 (08:47:40 CET)
ARTICLE
|
doi:10.20944/preprints202401.0661.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
Protozoan diseases; Drug repurposing; Cytotoxicity; Dihydrofolate reductase inhibitors; Potassium (K+) channel blocker; ADME properties
Online: 9 January 2024 (10:30:36 CET)
REVIEW
|
doi:10.20944/preprints202311.1632.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
checkpoint inhibitors; esophageal cancer; gastric cancer; immunotherapy; PD-L1; HER2; clinical trials; history; disparities
Online: 28 November 2023 (01:45:08 CET)
REVIEW
|
doi:10.20944/preprints202309.1061.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
prodrugs; HIV; AIDS; Nucleoside Reverse Transcriptase Inhibitors (NRTI); co-drugs; new drugs; medicinal chemistry
Online: 18 September 2023 (05:47:07 CEST)
REVIEW
|
doi:10.20944/preprints202308.0688.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Urothelial cell cancer; metastasis, drug resistance, immunotherapy; immune checkpoint inhibitors; tumorigenesis; antibody–drug conjugate.
Online: 9 August 2023 (08:23:29 CEST)
REVIEW
|
doi:10.20944/preprints202306.0994.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
hepatocellular carcinoma (HCC); LOXL2; tumor microenvironment (TME); extracellular matrix (ECM); LOXL2 inhibitors; target therapy
Online: 14 June 2023 (07:18:34 CEST)
ARTICLE
|
doi:10.20944/preprints202305.2226.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
melanoma; cutaneous melanoma; mucosal melanoma; uveal melanoma; immune-checkpoint inhibitors; metabolomics; tryptophan; kynurenine; spermine
Online: 31 May 2023 (10:45:46 CEST)
HYPOTHESIS
|
doi:10.20944/preprints202305.1129.v1
Subject:
Biology And Life Sciences,
Anatomy And Physiology
Keywords:
Lymphangiontrope; salt sensitivity; cardiorenal syndrome; SGLT2 inhibitors; Down’s syndrome; depression; schizophrenia; C Reactive Protein
Online: 16 May 2023 (08:51:13 CEST)
REVIEW
|
doi:10.20944/preprints202304.0516.v1
Subject:
Medicine And Pharmacology,
Internal Medicine
Keywords:
SGLT-2 Inhibitors; Inflammasome; NLRP3; reno-protective effects; Cardio-protective effects; neuro-protective effects.
Online: 18 April 2023 (10:33:39 CEST)
ARTICLE
|
doi:10.20944/preprints202211.0516.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
Antivirals; coronavirus; COVID-19; covalent drugs; dynamic light scattering; inhibitors; main protease; natural products
Online: 28 November 2022 (13:40:01 CET)
ARTICLE
|
doi:10.20944/preprints202103.0752.v1
Subject:
Biology And Life Sciences,
Anatomy And Physiology
Keywords:
Mixture toxicity; Neurotoxicity; Antagonism; Organophosphate; Acetylcholinesterase inhibitors; GABA; Behavior; Risk assessment; Spontaneous movement activity
Online: 31 March 2021 (07:52:05 CEST)
ARTICLE
|
doi:10.20944/preprints202102.0408.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
NhaP2-type cation-proton antiporter; Vibrio cholerae; Amiloride Analogs; Inhibitors against NhaP-type antiporters
Online: 18 February 2021 (10:39:07 CET)
REVIEW
|
doi:10.20944/preprints201902.0245.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
cyclin-dependent kinases; cyclin-dependent kinase 4 and 6 inhibitors; targeted therapies; breast cancer
Online: 27 February 2019 (04:48:54 CET)
ARTICLE
|
doi:10.20944/preprints201805.0209.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Vezf1; angiogenesis; vascular biology; endothelial cells; MSS31, tube formation, small molecule inhibitors computational modeling.
Online: 15 May 2018 (08:08:15 CEST)
ARTICLE
|
doi:10.20944/preprints201801.0196.v1
Subject:
Medicine And Pharmacology,
Urology And Nephrology
Keywords:
comorbid diseases; erectile dysfunction; penile duplex doppler ultrasound; penile pathology; phosphodiesterase type 5 inhibitors
Online: 22 January 2018 (09:03:17 CET)
ARTICLE
|
doi:10.20944/preprints202409.0004.v1
Subject:
Medicine And Pharmacology,
Cardiac And Cardiovascular Systems
Keywords:
drug-related side effects and adverse reactions; antihyperlipidemic medicines; angiotensin-converting enzyme (ACE) - inhibitors; sartans
Online: 2 September 2024 (03:31:18 CEST)
REVIEW
|
doi:10.20944/preprints202405.0573.v1
Subject:
Medicine And Pharmacology,
Gastroenterology And Hepatology
Keywords:
Proton Pump Inhibitors (PPIs); Vonoprazan (VPZ); Intravenous infusion; Oral therapy; Bleeding peptic ulcers; Endoscopic therapy
Online: 9 May 2024 (09:15:54 CEST)
REVIEW
|
doi:10.20944/preprints202308.1547.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
Main Protease Inhibitors; SARS-CoV-2; COVID-19; mutations; vaccines; therapeutics; drug repurposing; management strategies
Online: 22 August 2023 (09:31:05 CEST)
REVIEW
|
doi:10.20944/preprints202307.1557.v1
Subject:
Medicine And Pharmacology,
Cardiac And Cardiovascular Systems
Keywords:
vulnerable plaque; intravascular imaging; intravascular ultrasound; optical coherent tomography; computed tomography coronary angiography; PCSK9 inhibitors.
Online: 25 July 2023 (10:21:55 CEST)
ARTICLE
|
doi:10.20944/preprints202305.2032.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Hep-G2 hepatocarcinoma cell; Deuterium-depleted water; Deuterium-enriched water; Cyclooxygenase inhibitors; MAPK pathway; Apoptosis
Online: 30 May 2023 (04:02:57 CEST)
REVIEW
|
doi:10.20944/preprints202305.1239.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Hodgkin lymphoma; non-Hodgkin lymphoma; PD1 / PD-L1 checkpoint inhibitors; tumor mutational burden; predictive biomarkers
Online: 17 May 2023 (10:52:16 CEST)
ARTICLE
|
doi:10.20944/preprints202303.0539.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
Antibiotic resistance; metallo-β-lactamases; metal-dependent enzymes; broad-spectrum inhibitors; inhibition assays; enzyme kinetics
Online: 31 March 2023 (03:35:02 CEST)
REVIEW
|
doi:10.20944/preprints202111.0317.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Non-Hodgkin lymphoma; Epigenetics; DNA methylation; HAT; HDAC; EZH2; bromodomain inhibitors; Drug combination; clinical testing
Online: 17 November 2021 (23:45:00 CET)
ARTICLE
|
doi:10.20944/preprints202111.0125.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
artificial intelligence; de novo design; fragment-based drug discovery; HIV-1 inhibitors; pseudo natural products
Online: 8 November 2021 (09:23:49 CET)
REVIEW
|
doi:10.20944/preprints202012.0167.v2
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
Matrix metalloproteinase; MMPs; protease; TIMPs; exosite; small molecule inhibitors; monoclonal antibodies; proteomics; N-terminomics; TAILS
Online: 24 March 2021 (16:23:28 CET)
ARTICLE
Subject:
Chemistry And Materials Science,
Biomaterials
Keywords:
kinase inhibitors; pure drug nanoparticles; drug nanocrystals; bottom-up nanonization; nanoprecipitation; microfluidics; flow focusing technologies
Online: 2 March 2021 (11:29:18 CET)
REVIEW
|
doi:10.20944/preprints201803.0227.v1
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
Antivenom; snakebite; small molecule toxin inhibitors; oligonucleotides; antibodies; phage display; next generation antivenom; recombinant antivenom
Online: 27 March 2018 (13:41:46 CEST)
ARTICLE
|
doi:10.20944/preprints202408.1998.v1
Subject:
Public Health And Healthcare,
Public Health And Health Services
Keywords:
Covid; Vaccination; immune-mediated inflammatory disease; Methotrexate; Tumor Necrosis Factor Inhibitors; TNF-blocking Antibody; Autoimmune Diseases
Online: 28 August 2024 (10:39:29 CEST)
REVIEW
|
doi:10.20944/preprints202407.2623.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Tumor Mutational Burden (TMB); Immune Checkpoint Inhibitors (ICIs); Biomarkers; Cancer Immunotherapy; Cancer Treatment Outcomes; Personalized Medicine
Online: 2 August 2024 (11:50:44 CEST)
REVIEW
|
doi:10.20944/preprints202407.1744.v1
Subject:
Biology And Life Sciences,
Life Sciences
Keywords:
BRCA1; BRCA2; promoter methylation; breast cancer; ovarian; cancer; liquid biopsy; PARP inhibitors
Online: 23 July 2024 (07:30:06 CEST)
REVIEW
|
doi:10.20944/preprints202307.1242.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Immune checkpoint inhibitors (ICIs); Non–small cell lung cancer (NSCLC); PD-1 , PD-L1; CTLA-4
Online: 19 July 2023 (02:48:47 CEST)
REVIEW
|
doi:10.20944/preprints202306.1269.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
tumor microenvironment; extracellular matrix; proteoglycans; tumor-associated fibroblasts; tumor immunity; immune checkpoint inhibitors; tumor stroma; angiogenesis
Online: 19 June 2023 (03:16:16 CEST)
REVIEW
|
doi:10.20944/preprints202207.0256.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
cancer; immunotherapy; adverse events; immune checkpoints inhibitors; chimeric antigen receptor therapy; bispecific antibodies; toxicity; renal; oncology
Online: 18 July 2022 (09:21:56 CEST)
ARTICLE
|
doi:10.20944/preprints202109.0429.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
hepatocellular carcinoma; hepatic arterial infusion chemotherapy; cisplatin; sorafenib; multikinase inhibitors; risk factors; propensity score-matched analysis
Online: 24 September 2021 (12:38:25 CEST)
CASE REPORT
|
doi:10.20944/preprints202005.0220.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
checkpoint inhibitors; tuberculosis; non-small cell lung cancer (NSCLC); Anti-PD-1; toxicity management; immunotherapy; pembrolizumab
Online: 13 May 2020 (04:38:50 CEST)
REVIEW
|
doi:10.20944/preprints201809.0364.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
clear cell renal cell carcinoma; hypoxia inducible factors (HIFs); selenium; PD-L1; miRNA; VEGF; mTOR inhibitors
Online: 19 September 2018 (05:10:22 CEST)
REVIEW
|
doi:10.20944/preprints201806.0056.v1
Subject:
Medicine And Pharmacology,
Pathology And Pathobiology
Keywords:
mTOR; mTORC1; mTORC2; rapamycin; rapalogues; rapalogs; mTOR inhibitors; senescence; ageing; aging; cancer; neurodegeneration; immunosenescence; senolytics; biomarkers
Online: 5 June 2018 (09:49:19 CEST)
ARTICLE
|
doi:10.20944/preprints202008.0470.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Amyotrophic Lateral Sclerosis (ALS); Fronto-Temporal-Lobar-Dementia; Tauopathies; synaptic plasticity; long-term potentiation; spatial learning; inositol signaling; neurexin; K-homology RNA-binding domain; Fragile-X-associated Tremor-Ataxia syndrome
Online: 21 August 2020 (04:39:19 CEST)
ARTICLE
|
doi:10.20944/preprints202407.1916.v1
Subject:
Medicine And Pharmacology,
Gastroenterology And Hepatology
Keywords:
cardiovascular disease; hepatic fibrosis; metabolic dysfunction-associated steatotic liver disease; sodium-glucose cotransporter 2 inhibitors; serum lipids
Online: 24 July 2024 (08:27:35 CEST)
REVIEW
|
doi:10.20944/preprints202403.0061.v1
Subject:
Medicine And Pharmacology,
Clinical Medicine
Keywords:
Atrial Fibrillation; Heart Failure with Preserved Ejection Fraction (HFpEF); Cardiac Amyloidosis; Molecular Imaging; Catheter Ablation; SGLT2 Inhibitors
Online: 1 March 2024 (14:46:58 CET)
REVIEW
|
doi:10.20944/preprints202311.0836.v1
Subject:
Medicine And Pharmacology,
Cardiac And Cardiovascular Systems
Keywords:
Acute Decompensated Heart failure; fluid overload; loop diuretics; diuretic resistance; mineralocorticoid; SGLT2 inhibitors; ultrafiltration; Carbonic Anhydrase Inhibitor
Online: 14 November 2023 (07:52:29 CET)
ARTICLE
|
doi:10.20944/preprints202310.0830.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
ZST316; L-257; dimethylarginine dimethylaminohydrolase 1; DDAH1 inhibitors; triple negative breast cancer; pharmacokinetics; xenograft models; analytical chemistry
Online: 12 October 2023 (12:01:21 CEST)
REVIEW
|
doi:10.20944/preprints202310.0551.v1
Subject:
Medicine And Pharmacology,
Other
Keywords:
Diabetes; Chronic Kidney Disease; Treatment; Elderly; Geriatric; Dialysis; SGLT2 inhibitors; GLP1 Receptor Agonists; Non-steroidal Mineralocorticoid Antagonists
Online: 9 October 2023 (16:56:30 CEST)
REVIEW
|
doi:10.20944/preprints202309.1934.v1
Subject:
Medicine And Pharmacology,
Obstetrics And Gynaecology
Keywords:
uterine leiomyoma; fibroid; pregnancy; therapy; targets; inhibitors; vaccines; humanized antibodies; MED12; HMGA2; fumarate hydratase; IL17B; MMP11; MMP16
Online: 28 September 2023 (04:38:19 CEST)
ARTICLE
|
doi:10.20944/preprints202308.0290.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
RNA-binding protein; human antigen R (HuR); high-throughput virtual screening; small molecule inhibitors; RNA pulldown assay
Online: 3 August 2023 (10:11:15 CEST)
REVIEW
|
doi:10.20944/preprints202306.1029.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
immune checkpoint inhibitors; CAR-T cell therapy; new cancer therapies and perioperative implications; perioperative chemotherapy toxicity; pneumonitis
Online: 15 June 2023 (07:37:26 CEST)
ARTICLE
|
doi:10.20944/preprints202306.0867.v1
Subject:
Medicine And Pharmacology,
Urology And Nephrology
Keywords:
Sex differences; Chronic Kidney Disease; Atherosclerosis; Foam Cells; Parietal Epithelial Cells (PECs); Angiotensin-Converting Enzyme Inhibitors (ACEi)
Online: 13 June 2023 (03:22:47 CEST)
ARTICLE
|
doi:10.20944/preprints202108.0327.v3
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Melanoma; Core regulatory network; in silico perturbationSystems pharmacology; Boolean model; Small molecule inhibitors; Virtual screening; ADME; E2F1
Online: 12 June 2023 (10:22:29 CEST)
ARTICLE
|
doi:10.20944/preprints201908.0223.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
LSD1; molecular inhibitors; thieno[3,2-b]pyrrole-5-carboxamide derivatives; Molecular docking; 3D-QSAR; Molecular dynamics simulations
Online: 21 August 2019 (09:54:43 CEST)
ARTICLE
|
doi:10.20944/preprints201906.0074.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
agrobacterium tumefaciens-mediated transformation; citrus fruit; metal ion chelators; fruit-fungal interaction; transcription factor; virulence; protease inhibitors
Online: 10 June 2019 (09:56:16 CEST)
ARTICLE
|
doi:10.20944/preprints201811.0330.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
hyperpigmentation; tyrosinase inhibitors; 3-(2,4-dihydroxyphenyl)propionic acid; structure-activity relationship study; B16-F10 cellular melanogenesis inhibition
Online: 14 November 2018 (09:59:45 CET)
ARTICLE
|
doi:10.20944/preprints202403.1686.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
lung adenocarcinoma; drug-tolerant persister (DTP) cells; intrinsic resistance; tyrosine kinase inhibitors (TKIs); erlotinib; osimertinib; senescent cells; CD74
Online: 28 March 2024 (12:16:57 CET)
REVIEW
|
doi:10.20944/preprints202402.0153.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
angiotensin-converting enzyme(ACE); angiotensin-converting enzyme inhibitors (ACEi); angioedema; bradykinin mediated angioedema; tratement of ACEi induced AE
Online: 2 February 2024 (11:53:14 CET)
ARTICLE
|
doi:10.20944/preprints202307.0781.v1
Subject:
Biology And Life Sciences,
Life Sciences
Keywords:
DNA repair; homologous recombination deficiency; biomarkers; precision oncology; loss of heterozygosity; inhibitors of poly (ADP-ribose) polymerase (PARP)
Online: 12 July 2023 (07:50:04 CEST)
REVIEW
|
doi:10.20944/preprints202305.0122.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Non-small cell lung cancer (NSCLC); EGFR; Tyrosine kinase inhibitors (TKIs); Uncommon mutation; Compound mutation; Intracranial activity; Immunotherapy
Online: 3 May 2023 (09:29:08 CEST)
REVIEW
|
doi:10.20944/preprints202108.0372.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
immune checkpoint inhibitors; non-small cell lung carcinoma; PD-1; PD-L1; immune PET; immunotherapy; Radiomics; PET/CT
Online: 18 August 2021 (08:20:43 CEST)
ARTICLE
|
doi:10.20944/preprints201811.0609.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
immune checkpoint inhibitors; immune-related adverse events (irAEs); tolerance; ipilimumab; nivolumab; interleukin-2; hyperthermia; low-dose-combination therapy
Online: 28 November 2018 (10:23:31 CET)
ARTICLE
|
doi:10.20944/preprints201808.0307.v3
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Immune Checkpoint Inhibitors; anti-PD-1/PDL-1; anti-CTLA-4; gender; sex; Nivolumab; Pembrolizumab; Atezolizumab; Ipilimumab; Durvalumab
Online: 15 November 2018 (07:02:24 CET)
REVIEW
|
doi:10.20944/preprints201810.0577.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
myeloma; daratumumab; elotuzumab; isatuximab; CD38; JNJ- 63723283; denosumab; checkpoint inhibitors; BCMA; bispecific T-cell engager; antibody-drug conjugates
Online: 24 October 2018 (12:11:23 CEST)
REVIEW
|
doi:10.20944/preprints201807.0116.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
chemical space; chemoinformatics; data mining; databases; DNMT inhibitors; drug discovery; epi-informatics; molecular modeling; similarity searching; virtual screening
Online: 6 July 2018 (10:04:44 CEST)
ARTICLE
|
doi:10.20944/preprints202407.0339.v1
Subject:
Medicine And Pharmacology,
Urology And Nephrology
Keywords:
non-metastatic castration-resistant prostate cancer; androgen receptor signaling inhibitors; overall survival; prostate-specific antigen; real-world clinical practice
Online: 3 July 2024 (13:59:16 CEST)
ARTICLE
|
doi:10.20944/preprints202405.0084.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
natural extracts; chitosan; liposomes; encapsulation; drug release; coronavirus HCoV-0C43; antiviral activity; natural inhibitors of viral replication; cytotoxicity; phototoxicity
Online: 2 May 2024 (12:03:47 CEST)
REVIEW
|
doi:10.20944/preprints202401.0165.v1
Subject:
Medicine And Pharmacology,
Pulmonary And Respiratory Medicine
Keywords:
lung vascular endothelium; endothelial barrier integrity; zinc-dependent HDACs; deacetylation; HDAC inhibitors; acute lung injury; acute respiratory distress syndrome
Online: 3 January 2024 (07:42:38 CET)
ARTICLE
|
doi:10.20944/preprints202110.0145.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
immune checkpoint inhibitors; PD-1; PD-L1; CTLA-4; immunotherapy; target therapy; BRAF; MET; melanoma; [18F]FDG PET/CT
Online: 8 October 2021 (14:14:14 CEST)
ARTICLE
|
doi:10.20944/preprints202104.0270.v1
Subject:
Chemistry And Materials Science,
Analytical Chemistry
Keywords:
Systemic amyloidosis; amyloid fibrils; amyloidogenesis inhibitors; antibody light chains; light chain stabilizers; doxycycline; EGCG; thioflavin T; filter trap; PAINS
Online: 9 April 2021 (15:07:24 CEST)
ARTICLE
|
doi:10.20944/preprints202403.1880.v1
Subject:
Public Health And Healthcare,
Other
Keywords:
Anti-interferon-γ autoantibodies; herpes zoster; monocyte chemoattractant protein-1; IFN-γ inducible protein-10; Janus kinas inhibitors; rheumatoid arthritis.
Online: 1 April 2024 (10:20:44 CEST)
REVIEW
|
doi:10.20944/preprints202402.1384.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
Cystic fibrosis; Pseudomonas aeruginosa; Antivirulence therapy; Quorum quenching and biofilm inhibition; Lectin and efflux pump inhibitors; Iron chelation
Online: 23 February 2024 (15:01:30 CET)
REVIEW
|
doi:10.20944/preprints202309.0860.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
gastrointestinal cancer; immunotherapy; cancer vaccines; dendritic cell vaccine; adoptive cell treatment; cytokine-induced killer cells; immune checkpoint inhibitors; angiogenesis inhibition
Online: 13 September 2023 (10:07:21 CEST)
REVIEW
|
doi:10.20944/preprints202308.1518.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
SARS-CoV-2; main protease; inhibitors; molecular modeling; molecular dynamics simulations; binding energy calculation; ADME properties; potential therapeutics; drug discovery
Online: 22 August 2023 (07:19:37 CEST)
ARTICLE
|
doi:10.20944/preprints202212.0206.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Cell-to-cell fusion; proprotein convertases; metalloproteases; mutagenesis; PCSK9; protease inhibitors; SARS-CoV-2; shedding; SKI-1/S1P; SREBP-2.
Online: 12 December 2022 (14:20:01 CET)
ARTICLE
|
doi:10.20944/preprints202110.0297.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
gastric cancer; immunotherapy; immune checkpoint blockade (ICB); immune checkpoint inhibitors (ICI),; DNA repair gene signature (DRGS); prognostic biomarker; score system
Online: 20 October 2021 (22:47:19 CEST)
REVIEW
|
doi:10.20944/preprints201902.0101.v1
Subject:
Medicine And Pharmacology,
Ophthalmology
Keywords:
age-related macular degeneration; anti-inflammatory agents; dry AMD; geographic atrophy; intravitreal injection; complement inhibitors; neuroprotective agents; non-exudative AMD
Online: 12 February 2019 (11:00:52 CET)
REVIEW
|
doi:10.20944/preprints202402.0632.v2
Subject:
Medicine And Pharmacology,
Other
Keywords:
Mycobacterium avium ss. paratuberculosis (MAP); Human endogenous retrovirus; HERV; Type 1 Diabetes; Multiple Sclerosis; Rheumatoid Arthritis; Amyotrophic lateral sclerosis (ALS); Alzheimer’ s disease (AD); Parkinson’ s disease (PD); Glioblastoma; Bromoepiandrosterone (BEA); Temelimab; BNN27
Online: 19 February 2024 (16:27:10 CET)
REVIEW
|
doi:10.20944/preprints202403.1790.v1
Subject:
Public Health And Healthcare,
Public Health And Health Services
Keywords:
heart failure; reduced ejection fraction; SGLT2 inhibitors; vericiguat; CardioMEMS; Cardiac Contractility Modulation; Left bundle branch area pacing; Wearable cardioverter defibrillators; Ultrafiltration
Online: 28 March 2024 (17:15:23 CET)
REVIEW
|
doi:10.20944/preprints202402.1593.v1
Subject:
Medicine And Pharmacology,
Endocrinology And Metabolism
Keywords:
type 2 diabetes; therapeutic inertia; clinical guidelines; sodium-glucose cotransporter-2 inhibitors; glucagon-like peptide-1 receptor agonists; primary health care
Online: 28 February 2024 (10:53:42 CET)
ARTICLE
|
doi:10.20944/preprints202308.0332.v2
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
homologous recombination deficiency (HRD); biomarkers; ovarian cancer; DNA repair; BRCA1/2; poly (ADP–ribose) polymerase inhibitors (PARPi); next generation sequencing (NGS)
Online: 6 September 2023 (09:09:09 CEST)
COMMUNICATION
|
doi:10.20944/preprints202305.1298.v1
Subject:
Biology And Life Sciences,
Life Sciences
Keywords:
Mass spectrometry; RAS; ACE; ACE2; CPN; bradykinin; hypertension; cardiovascular disease; antihypertensiva; ACE inhibitors; angiotensin receptor blockers; bradykinin; neuropeptide re-porter assay
Online: 18 May 2023 (08:13:10 CEST)