ARTICLE
|
doi:10.20944/preprints202209.0232.v1
Subject:
Medicine And Pharmacology,
Pharmacy
Keywords:
Drug use review; Outpatients; Ghana; SORT IT; Quality indicators; Electronic Medical Records; Operational research; Rational use of medicines
Online: 15 September 2022 (13:39:06 CEST)
ARTICLE
|
doi:10.20944/preprints202104.0169.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Split-intein circular ligation of peptides and proteins (SICLOPPS); cyclic peptide libraries; protein–protein interactions; drug; gateway cloning
Online: 6 April 2021 (10:19:49 CEST)
ARTICLE
|
doi:10.20944/preprints202008.0316.v1
Subject:
Chemistry And Materials Science,
Nanotechnology
Keywords:
nanoparticles; FA-DABA-SMA; drug delivery systems; folic acid receptor alpha; intracellular disruptions; invasion and migration; breast cancer
Online: 14 August 2020 (09:49:17 CEST)
ARTICLE
|
doi:10.20944/preprints201908.0177.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
chronic myeloid leukemia; tyrosine kinase inhibitor; adverse drug event; quality of life; second-generation tyrosine kinase inhibitor; nilotinib
Online: 16 August 2019 (08:09:07 CEST)
ARTICLE
|
doi:10.20944/preprints201905.0109.v2
Subject:
Medicine And Pharmacology,
Pediatrics, Perinatology And Child Health
Keywords:
child; diarrhea; water sanitation and hygiene; rehydration solution; zinc; case management; antibacterial agents; drug utilization; community participation; India
Online: 14 May 2019 (11:46:53 CEST)
REVIEW
|
doi:10.20944/preprints201812.0273.v3
Subject:
Biology And Life Sciences,
Biophysics
Keywords:
mutations; disease-causing mutations; polymorphism; folding free energy change; binding free energy change; drug discovery; in silico screening
Online: 28 January 2019 (11:39:23 CET)
ARTICLE
|
doi:10.20944/preprints201809.0513.v1
Subject:
Medicine And Pharmacology,
Tropical Medicine
Keywords:
Malawi, HIV, tuberculosis, anti-retroviral therapy, surveillance, patient monitoring, epidemic trends, drug supply, unique patient identifiers, data analysis
Online: 27 September 2018 (15:29:43 CEST)
REVIEW
|
doi:10.20944/preprints201807.0116.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
chemical space; chemoinformatics; data mining; databases; DNMT inhibitors; drug discovery; epi-informatics; molecular modeling; similarity searching; virtual screening
Online: 6 July 2018 (10:04:44 CEST)
REVIEW
|
doi:10.20944/preprints201802.0190.v1
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
Alzheimer’s disease; biomimetic nanocarriers; blood-brain barrier; dementia; drug targeting; lipid cubic phases; nanoemulsion; SR-BI; scavenger receptors
Online: 28 February 2018 (07:49:13 CET)
REVIEW
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
metabolic functionalization of alkyl moieties in drug molecules; structure influence on metabolic functionalization of alkyl moieties; mechanism of alkyl free radical hydroxy functionalization; pharmacologic activity of hydroxy and carboxy functionalized alkyl moieties in drug molecules; primary and auxiliary pharmacophores; auxophores
Online: 11 March 2020 (03:20:58 CET)
ARTICLE
|
doi:10.20944/preprints202405.1741.v1
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
Alzheimer’ s disease; vascular complications; monoclonal antibody therapy; Aducanumab; Lecanemab; epoxide of polyunsaturated fatty acid; soluble epoxide hydrolase inhibitor EC5026; EP4 inhibitor; monocyte/macrophage; amyloid-beta degradation
Online: 27 May 2024 (13:00:54 CEST)
REVIEW
|
doi:10.20944/preprints202105.0183.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Intravenous Immunoglobulin (IVIg); Human Leukocyte Antigen-I (HLA-1); Polyreactive mAbs; Monospecific mAbs; Shared epitopes; Immunosuppression; T-cells; B-memory cells; T-regulatory Cells; Blastogenesis, proliferation, Antibody production
Online: 10 May 2021 (12:30:03 CEST)
REVIEW
|
doi:10.20944/preprints202004.0201.v2
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
SARS-CoV-2 Detection, SARS-CoV-2 Antibody Test, SARS-CoV-2 Antigen Test, False Negative, False Positive, Sensitivity, Specificity, Point-of-care testing (POCT), SARS-CoV-2 Mutants
Online: 25 March 2021 (15:33:14 CET)
REVIEW
|
doi:10.20944/preprints202410.1226.v1
Subject:
Medicine And Pharmacology,
Gastroenterology And Hepatology
Keywords:
acute pancreatitis biology; gross anatomy; pancreatic histology; inflammation and immunology; diagnostics; histopathology; biomarkers; drug discovery; epidemiology and etiology; embryology
Online: 15 October 2024 (20:39:39 CEST)
REVIEW
|
doi:10.20944/preprints202410.0440.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
pharmacometrics; autoimmune diseases; personalized medicine; PBPK modeling; PK/PD modeling; disease progression modeling; population modeling; AI in drug development
Online: 8 October 2024 (09:45:29 CEST)
REVIEW
|
doi:10.20944/preprints202409.1648.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
G-protein-coupled receptors (GPCR); Peptide; Cell growth; Apoptosis; Peptide antagonists; Peptide signaling pathways; Cancer; Cancer therapy; Drug design
Online: 23 September 2024 (10:01:42 CEST)
HYPOTHESIS
|
doi:10.20944/preprints202407.1192.v2
Subject:
Medicine And Pharmacology,
Clinical Medicine
Keywords:
Homeostasis; Epigenetics; Epimutations; Hormesis; Toxicogenomics; Quantum biology; Superposition reference image; Ultra high dilutions; Quantum drug action
Online: 16 September 2024 (10:16:10 CEST)
REVIEW
|
doi:10.20944/preprints202408.1673.v1
Subject:
Chemistry And Materials Science,
Biomaterials
Keywords:
biomaterial; biocompatibility; collagen; derivatives of collagen; medical applications; tissue engineering and regeneration; drug delivery systems; bioinks for 3D bioprinting
Online: 23 August 2024 (00:15:55 CEST)
ARTICLE
|
doi:10.20944/preprints202406.0762.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
high-throughput screening; metabolic stability; ambient mass spectrometry; LA-REIMS; biomimetic metalloporphyrin; lead profiling; in vitro models; drug metabolism
Online: 12 June 2024 (14:15:32 CEST)
ARTICLE
|
doi:10.20944/preprints202406.0258.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
Parkinson-like events; Japanese Adverse Drug Event Report database; spontaneous reporting system; volcano plot; hierarchical clustering; principal component analysis
Online: 5 June 2024 (08:25:00 CEST)
ARTICLE
|
doi:10.20944/preprints202405.0084.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
natural extracts; chitosan; liposomes; encapsulation; drug release; coronavirus HCoV-0C43; antiviral activity; natural inhibitors of viral replication; cytotoxicity; phototoxicity
Online: 2 May 2024 (12:03:47 CEST)
REVIEW
|
doi:10.20944/preprints202402.1435.v1
Subject:
Medicine And Pharmacology,
Internal Medicine
Keywords:
secondary movement disorders; dystonia; chorea; athetosis; myoclonus; tics; tremor; drug-induced movement disorders; post-infectious movement disorders; metabolic disorders
Online: 26 February 2024 (11:45:00 CET)
ARTICLE
|
doi:10.20944/preprints202305.2131.v1
Subject:
Medicine And Pharmacology,
Ophthalmology
Keywords:
glaucoma; corticosteroids; intraocular pressure; Japanese Adverse Drug Event Report; spontaneous reporting system; volcano plot; hierarchical clustering; principal component analysis
Online: 30 May 2023 (11:43:13 CEST)
ARTICLE
|
doi:10.20944/preprints202305.0650.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
3D printing; hybrid scaffold; poly(caprolactone); chitosan; vancomycin; mesenchymal stem cells; tissue engineering; drug-delivery systems (DDSs); M osteomyelitis
Online: 9 May 2023 (12:05:37 CEST)
ARTICLE
|
doi:10.20944/preprints202304.1195.v1
Subject:
Medicine And Pharmacology,
Epidemiology And Infectious Diseases
Keywords:
COVID-19 pandemic; antimicrobial resistance; infectious diseases consultation; multi-drug resistant bacteria; infection prevention and control group; antibiotic stewardship
Online: 29 April 2023 (03:23:00 CEST)
ARTICLE
|
doi:10.20944/preprints202209.0417.v1
Subject:
Medicine And Pharmacology,
Cardiac And Cardiovascular Systems
Keywords:
Recreational substance abuse; drug abuse; marijuana; amphetamine; acute ischemic stroke; risk factors; young adult; NIS; Stroke; Sudden Cardiac Death
Online: 27 September 2022 (09:41:00 CEST)
REVIEW
|
doi:10.20944/preprints202108.0447.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
Interferons; IFNα; IFNß; IFNγ; antiviral; antiproliferative; immunomodulator; PEGylation; formulation; encapsulate IFNs; drug delivery system; liposomes; polymeric micelles; microparticles; nanoparticles
Online: 23 August 2021 (13:51:44 CEST)
REVIEW
|
doi:10.20944/preprints202101.0625.v1
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
Alzheimer’s disease; dementia, beta-amyloid; germ theory; drug development; clinical trials; herpes; spirochetes; Chlamydia pneumoniae; Porphyromonas gingivalis; toxoplasma; mycobacteria
Online: 29 January 2021 (13:57:18 CET)
REVIEW
|
doi:10.20944/preprints202012.0044.v1
Subject:
Biology And Life Sciences,
Anatomy And Physiology
Keywords:
Integrins; Tumor Microenvironment; Drug Resistance; Migration; Metastasis; Solid Tumors; The Cancer Genome Atlas; Gene Expression; Computational Biology; Therapeutic Targeting
Online: 1 December 2020 (18:26:11 CET)
ARTICLE
|
doi:10.20944/preprints202011.0474.v1
Subject:
Biology And Life Sciences,
Endocrinology And Metabolism
Keywords:
Breast cancer, genome-scale metabolic models, constraint-based analysis, divergence analysis, gene expression, metabolism, drug targets, personalized metabolic networks.
Online: 18 November 2020 (12:29:02 CET)
ARTICLE
|
doi:10.20944/preprints202011.0054.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
3D printing; semi-solid extrusion 3D printing; additive manufacturing; extemporaneous manufacturing; drug delivery; personalized dosage forms; veterinary medicine; prednisolone
Online: 2 November 2020 (14:59:30 CET)
REVIEW
|
doi:10.20944/preprints202010.0179.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Non Michaelis-Menten Kinetics; High-throughput screening; allostery; cooperativity; processive kinetics; distributive kinetics; single-molecule; auto-catalytic; drug discovery
Online: 8 October 2020 (13:34:16 CEST)
ARTICLE
|
doi:10.20944/preprints202005.0199.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
SARS-CoV-2; COVID-19; CADD; virtual screening; approved drugs; drug repurposing; essential targets; molecular docking; molecular dynamics simulations
Online: 11 May 2020 (13:14:18 CEST)
REVIEW
Subject:
Medicine And Pharmacology,
Cardiac And Cardiovascular Systems
Keywords:
acute coronary syndromes; myocardial infarction; STEMI; Covid-19, infectious disease; respiratory infections; pathophysiology; percutaneous coronary intervention; thrombolysis; drug treatment
Online: 7 May 2020 (12:49:39 CEST)
ARTICLE
|
doi:10.20944/preprints202004.0198.v1
Subject:
Medicine And Pharmacology,
Gastroenterology And Hepatology
Keywords:
mathematical modelling; peristalsis; smoothed particle hydrodynamics (SPH); fluid dynamics; large intestine; colonl proximal colon; fluid-structure interactions; drug delivery
Online: 12 April 2020 (15:57:17 CEST)
ARTICLE
|
doi:10.20944/preprints201811.0574.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
activity cliff; activity landscape plotter; epigenetics; docking; drug discovery; D-tools; molecular dynamics; Epi-polypharmacology; SmART; structure-activity relationships
Online: 26 November 2018 (07:14:05 CET)
ARTICLE
|
doi:10.20944/preprints202409.2168.v1
Subject:
Public Health And Healthcare,
Health Policy And Services
Keywords:
opium crisis; opioid epidemic; Qing Dynasty; United States; drug policy; historical comparison; national power; military influence; public health; international relations
Online: 27 September 2024 (07:48:44 CEST)
ARTICLE
|
doi:10.20944/preprints202407.0891.v1
Subject:
Chemistry And Materials Science,
Nanotechnology
Keywords:
multi-drug-resistant bacteria; triphenyl phosphonium salts; mitochondria target bola-amphiphiles; membranes permeabilization; MICs determination; time-killing experiments; cytotoxicity studies
Online: 11 July 2024 (11:27:17 CEST)
ARTICLE
|
doi:10.20944/preprints202405.0360.v1
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
Traumatic brain injury; TBI; secondary injury; peptide therapeutics; cell penetrating peptide; pro-inflammatory cytokines; intranasal drug delivery; blood brain barrier
Online: 7 May 2024 (11:13:30 CEST)
ARTICLE
|
doi:10.20944/preprints202404.0875.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
humidity variation; temperature variation; X-ray crystallography; peptides; polymorphism; octreotide; drug stability; in situ X-ray powder diffraction
Online: 15 April 2024 (11:34:32 CEST)
ARTICLE
|
doi:10.20944/preprints202403.0045.v1
Subject:
Chemistry And Materials Science,
Biomaterials
Keywords:
heterograft copolymer; hydrogel; alginate; thermo-responsive; pH-responsive; poly(2- vinyl pyridine)-b-polyethylene oxide; diblock copolymer micelles; drug delivery
Online: 1 March 2024 (12:03:46 CET)
REVIEW
|
doi:10.20944/preprints202401.0233.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Gold nanoparticle; nanomedicine; glioblastoma multiforme; blood-brain barrier; brain tumor treatment; targeted drug delivery; radiation treatment; boron neutron capture therapy
Online: 3 January 2024 (10:03:43 CET)
ARTICLE
|
doi:10.20944/preprints202312.1519.v1
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
Durysta, Bimatoprost; Ciliary Sulcus, Middle Space Operations; MiSO; Middle Space Therapeutics; MiST; ArcScan; Ultrasound; Depot; Drug Delivery; Posterior Chamber; Sulcus
Online: 20 December 2023 (09:09:38 CET)
REVIEW
|
doi:10.20944/preprints202312.1173.v1
Subject:
Biology And Life Sciences,
Neuroscience And Neurology
Keywords:
Alzheimer’s disease; transgenic animal model; amyloidogenesis; amyloid-beta; peptide; isoaspartate; zinc; α4β2 nicotinic acetylcholine receptor; aggregation seeding; anti-amyloid drug
Online: 15 December 2023 (12:23:06 CET)
REVIEW
|
doi:10.20944/preprints202312.0387.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
big data; not-so-big data; molecular design; drug design; machine learning; artificial intelligence; descriptor; computer-generated descriptors; property; regression
Online: 6 December 2023 (10:19:02 CET)
ARTICLE
|
doi:10.20944/preprints202308.1493.v1
Subject:
Medicine And Pharmacology,
Pharmacy
Keywords:
silver nanoparticles; chlorhexidine; conjunction; complexation; surface functionalization; nano-scaled drug delivery; antimicrobial synergism; antiviral activity; Camellia sinensis catechins; green synthesis
Online: 22 August 2023 (09:52:09 CEST)
REVIEW
|
doi:10.20944/preprints202308.1518.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
SARS-CoV-2; main protease; inhibitors; molecular modeling; molecular dynamics simulations; binding energy calculation; ADME properties; potential therapeutics; drug discovery
Online: 22 August 2023 (07:19:37 CEST)
ARTICLE
|
doi:10.20944/preprints202305.1605.v1
Subject:
Medicine And Pharmacology,
Pharmacy
Keywords:
pH sensitive Polymer; Methacrylate Polymers; Eudragit L100; Polymeric nanoparticles; Apocynin; Rheumatoid arthritis; Carbopol-934 based Hydrogel; Transdermal Drug Delivery System
Online: 23 May 2023 (07:51:12 CEST)
ARTICLE
|
doi:10.20944/preprints202305.1334.v1
Subject:
Public Health And Healthcare,
Public Health And Health Services
Keywords:
victimizing and perpetrating violence; interpersonal and intimate violence; harmful alcohol and drug use; mental health symptoms; paths of violence; gender
Online: 18 May 2023 (10:46:13 CEST)
REVIEW
|
doi:10.20944/preprints202305.0034.v1
Subject:
Biology And Life Sciences,
Cell And Developmental Biology
Keywords:
organ-on-a-chip; gut-on-a-chip; intestine; in vitro; ex vivo; ADME; oral bioavailability; drug development; microbiome; IBD
Online: 2 May 2023 (01:15:08 CEST)
ARTICLE
|
doi:10.20944/preprints202303.0192.v1
Subject:
Biology And Life Sciences,
Anatomy And Physiology
Keywords:
Phenome; Matrisome; Matreotype; Phenotype; Extracellular Matrix; Data Mining; SNP; PheWAS; GWAS; Electronic Health Records; Drug Repurposing; Precision Medicine; Collagen; Human
Online: 10 March 2023 (09:34:15 CET)
REVIEW
Subject:
Biology And Life Sciences,
Virology
Keywords:
Chikungunya virus; alphavirus; antiviral therapy; direct-acting antivirals; host-directed antivirals; in silico screening; in vivo validation; antiviral drug development
Online: 10 June 2021 (09:15:45 CEST)
ARTICLE
|
doi:10.20944/preprints202101.0478.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
ocular drug delivery system; topical liposomes; posterior segment of the eye; safety and toler-ability; biologic activity; diabetic macular edema
Online: 25 January 2021 (10:48:51 CET)
REVIEW
|
doi:10.20944/preprints201812.0170.v1
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
bacterial nanocellulose; nanofibrillated nanocellulose; animal nanocellulose; algal nanocellulose; tissue engineering; tissue repair; wound dressing; cell delivery; drug delivery; antimicrobial properties
Online: 14 December 2018 (06:44:53 CET)
REVIEW
|
doi:10.20944/preprints201810.0204.v2
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
DNA origami; aptamer; DNA nanotechnology; protein nano array; biosensor; logic gate; enzyme cascade; drug delivery system; targeted therapy; molecular robotics
Online: 22 October 2018 (10:57:21 CEST)
ARTICLE
|
doi:10.20944/preprints201904.0205.v1
Subject:
Chemistry And Materials Science,
Analytical Chemistry
Keywords:
antibody coating; proximity-enhanced reaction; immunoglobulins; IgG; protein A; protein G; bio-interaction; immunoprecipitation; pull-down assay; immunocapture; stabilization; yield; regeneration; nanoparticles; microparticles; biochips; immunosensor; photochemical crosslinker; click chemistry; herceptin; trastuzumab
Online: 18 April 2019 (07:55:11 CEST)
ARTICLE
|
doi:10.20944/preprints202410.1864.v1
Subject:
Chemistry And Materials Science,
Applied Chemistry
Keywords:
Sodium valproate; antiepileptic drug, spectrophotometric quantitative analysis method; light yellow azo dye; official declared pure amount; pharmaceutical tablet; statistical validation procedure
Online: 23 October 2024 (16:40:43 CEST)
ARTICLE
|
doi:10.20944/preprints202407.1672.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
immune imbalance; Immune Imbalance Transcriptomics; IIT; B-cell lymphoma; Systemic Lupus Erythematosus (SLE); RNA-seq; algorithm; drug discovery; cancer; autoimmune disease
Online: 22 July 2024 (09:33:39 CEST)
REVIEW
|
doi:10.20944/preprints202405.1223.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
antipsychotic drug; M4 and M1 receptor agonist; negative schizophrenia symptoms; neural network; schizophrenia; trace-amine-associated receptor 1 agonist; ulataront; xanomeline
Online: 20 May 2024 (12:31:08 CEST)
REVIEW
|
doi:10.20944/preprints202307.2136.v1
Subject:
Public Health And Healthcare,
Public Health And Health Services
Keywords:
Epilepsy; Pediatric Drug Development (PDD); Therapeutic Orphans; Extrapolation of efficacy from adults to children; Antiseizure Medications (ASMs); Pediatric Investigation Plan (PIP)
Online: 1 August 2023 (02:49:45 CEST)
ARTICLE
|
doi:10.20944/preprints202307.0133.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
Hydrophilic polymers; Thermo-responsive polymers; Polymer drug delivery system; Tumor-specific targeting; Recombinant proteins; Non-covalent attachment; Tris(nitrilotriacetic acid) ligation
Online: 4 July 2023 (08:01:27 CEST)
ARTICLE
|
doi:10.20944/preprints202303.0322.v1
Subject:
Computer Science And Mathematics,
Computer Science
Keywords:
Hemolytic peptide; Network science; Half-Space Proximal Networks; Metadata Networks; Visual mining; Cluster analysis; Motif discovery; StarPep toolbox; Peptide drug discovery
Online: 17 March 2023 (10:05:05 CET)
ARTICLE
|
doi:10.20944/preprints202206.0177.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Deuterium-depleted water (DDW); deuterium-depleted organic compounds (DDOC); anticancer drug development; D/H ratio; production of metabolic water; ketogenic diet
Online: 13 June 2022 (09:49:32 CEST)
ARTICLE
Subject:
Chemistry And Materials Science,
Nanotechnology
Keywords:
Sepiapterin; triacetyl-β-cyclodextrin (TAβCD); hydrophilic drug/cyclodextrin complexes; spray-drying; methoxy-poly(ethylene-glycol)-poly(epsilon-caprolactone) (mPEG-PCL) nanoparticles
Online: 24 May 2019 (11:42:42 CEST)
REVIEW
|
doi:10.20944/preprints201805.0426.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
biological activity; crosslinking; drug delivery; cosmetic; food-supplement; functionalization; hyaluronan applications; hyaluronan derivatives; hyaluronan synthases; hyaluronic acid; hyaluronidases; physico-chemical properties
Online: 29 May 2018 (12:13:48 CEST)
ARTICLE
|
doi:10.20944/preprints201804.0245.v1
Subject:
Chemistry And Materials Science,
Polymers And Plastics
Keywords:
Chitosan-g-PMMA amphiphilic nanoparticles; thiolated polymers; mucoadhesion; mucosal drug delivery; Caco2 and HT29-MTX cell lines; apparent permeability in vitro.
Online: 18 April 2018 (16:28:21 CEST)
ARTICLE
|
doi:10.20944/preprints202409.0790.v1
Subject:
Biology And Life Sciences,
Life Sciences
Keywords:
Glioblastoma; Glioblastoma stem cells (GSCs); Auranofin; thioredoxin reductase; oxidative stress; glutathione (GSH); reactive oxygen species (ROS); piperlongumine, antioxidant; drug repurposing
Online: 10 September 2024 (09:50:35 CEST)
REVIEW
|
doi:10.20944/preprints202312.1480.v1
Subject:
Chemistry And Materials Science,
Nanotechnology
Keywords:
Nano-drugs; Nanoparticle; Delivery System; Vaccine; Liposome; Exosome; Stealth Effect; SLN; Inclusion and Dispersion Systems; Solid State Reactive Mixing; Nanosome; Drug Carrier
Online: 20 December 2023 (10:54:31 CET)
REVIEW
|
doi:10.20944/preprints202307.1284.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Cancer; tumourigenesis; drug resistance; signalling pathways; Wnt/β-catenin pathway; JAK/STAT pathway; PI3K/Akt/mTOR pathway; RAS/RAF/MAPK/ERK signalling
Online: 19 July 2023 (09:14:02 CEST)
ARTICLE
|
doi:10.20944/preprints202306.1818.v1
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
Alternative Splicing; two-colour (GFP/RFP) Fluorescent Reporter; MAPT; Exon-Skipping; FTDP-17; High Content Screening; siRNA; Nucleic Acids Therapeutics; Drug discovery
Online: 26 June 2023 (13:55:26 CEST)
ARTICLE
|
doi:10.20944/preprints202305.1948.v1
Subject:
Public Health And Healthcare,
Public Health And Health Services
Keywords:
Kyrgyz Republic; drug-sensitive pulmonary TB; electronic register system; paper-based records; completeness; concordance; treatment initiation; treatment outcomes; SORT IT; operational research
Online: 29 May 2023 (02:49:28 CEST)
ARTICLE
|
doi:10.20944/preprints202202.0194.v1
Subject:
Medicine And Pharmacology,
Pulmonary And Respiratory Medicine
Keywords:
antifungal resistance; isavuconazole; cystic fibrosis; pulmonary disease; Aspergillus fumigatus; pulmonary aspergillosis; respiratory disease; antifungal stewardship; therapeutic drug monitoring; minimum inhibitory concentration (MIC)
Online: 16 February 2022 (05:12:39 CET)
REVIEW
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
Parkinson’s disease; precision medicine; personalized medicine; GBA; Glucocerebrosidase; GCase; LRRK2; Leucine-rich repeat kinase-2; Dopamine; PD drug trials; PD risk variants
Online: 14 September 2020 (00:22:59 CEST)
REVIEW
|
doi:10.20944/preprints201909.0306.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
influenza virus; humoral response; hemagglutinin (HA) of influenza virus; broad neutralizing antibody(bnAb); heterosubtypic immunity of influenza; original antigenic sin "OAS"; "universal" influenza vaccine; protein microarray assay; mPLEX-Flu assay; multiple dimensional assays (MDA))
Online: 27 September 2019 (08:34:56 CEST)
ARTICLE
|
doi:10.20944/preprints202401.0070.v2
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
cancer growth; tumor metastasis; cancer's Warburg effect; p53; p53 (re)activators; mitochondrial apoptosis; cytochrome c release; tumoricidal drug effect
Online: 4 January 2024 (09:34:19 CET)
ARTICLE
|
doi:10.20944/preprints202304.0534.v1
Subject:
Medicine And Pharmacology,
Otolaryngology
Keywords:
micro injection molding; 3D printing; rapid tooling; digital light processing; implant; drug delivery system; dexamethasone; anti-inflammatory; TNF-α; biocompatibility; inner ear therapy
Online: 19 April 2023 (03:57:41 CEST)
ARTICLE
|
doi:10.20944/preprints202002.0003.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
drug repositioning/repurposing; dopamine transporter (DAT); benztropine; tumoroids; signal transducer and activator of transcription (STAT); circulating tumor cells (CTC); three-dimensional (3D) culture
Online: 3 February 2020 (03:16:54 CET)
ARTICLE
|
doi:10.20944/preprints202408.1334.v1
Subject:
Chemistry And Materials Science,
Analytical Chemistry
Keywords:
Sodium valproate; antiepileptic drug; spectrophotometric quantitative analysis method; light yellow azo dye; official declared pure amount; quantitative color reaction; statistical validation procedure
Online: 19 August 2024 (14:27:53 CEST)
REVIEW
|
doi:10.20944/preprints202309.0459.v2
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
migraine disorders; headache disorders; nociceptive pain; analgesics; calcitonin gene-related peptide; pituitary adenylate cyclase-activating polypeptide (PACAP); vasoactive intestinal peptide; adrenomedullin; neuropeptides; drug development
Online: 17 October 2023 (10:50:15 CEST)
ARTICLE
|
doi:10.20944/preprints202308.1050.v1
Subject:
Chemistry And Materials Science,
Applied Chemistry
Keywords:
transungual; antifungal nail lacquer; Itraconazole Nail Medication; Nail Drug Uptake; Nail penetration; Nail Plate Application; itraconazole hydrochloride; Topical Nail Polish; nail clipping; Nail Diffusion
Online: 15 August 2023 (07:06:34 CEST)
ARTICLE
|
doi:10.20944/preprints202202.0046.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
Cancer; tumor homing peptide; in silico drug discovery; complex network; chemical space network; centrality measure; similarity searching, group fusion; motif discovery; starPep toolbox software
Online: 3 February 2022 (10:14:05 CET)
REVIEW
|
doi:10.20944/preprints202005.0234.v1
Subject:
Computer Science And Mathematics,
Artificial Intelligence And Machine Learning
Keywords:
SIRD; Twitter; GHSI; Pre-symptomatic; EHR; Contact tracing; On-line survey; qRT-PCR; X-ray; CT/HRCT; CNN; Autoencoder; Drug affinity; CPI; and Inflation.
Online: 14 May 2020 (11:25:57 CEST)
ARTICLE
|
doi:10.20944/preprints202410.0969.v1
Subject:
Public Health And Healthcare,
Public Health And Health Services
Keywords:
Two-dimensional NMR spectroscopy; pharmaceutical research; structural elucidation; drug characterization; quality control; formulation development; natural products; COSY; HSQC; HMBC; cryogenic probes; high-field spectrometers; metabolomics; structural biology; drug discovery; analytical chemistry; pharmaceutical innovation; intellectual property protection; challenges; technological advancements; future prospects; complex molecules; sensitivity issues; cost of equipment; data analysis; regulatory compliance
Online: 12 October 2024 (09:58:43 CEST)
ARTICLE
|
doi:10.20944/preprints202405.1511.v1
Subject:
Biology And Life Sciences,
Cell And Developmental Biology
Keywords:
Breast cancer; network pharmacology; text mining; drug therapy; genes; pathway analysis; biological process; protein-protein interaction; degree and betweenness; molecular docking; meristematic cells; anti-mitotic; hepatotoxicity
Online: 23 May 2024 (07:34:57 CEST)
REVIEW
|
doi:10.20944/preprints202311.0529.v1
Subject:
Public Health And Healthcare,
Primary Health Care
Keywords:
SARS-CoV-2; Papain-like protease; COVID-19; Molecular modelling; Molecular dynamics simulations; Drug discovery; Antiviral drugs; Inhibitors; Therapeutic agents; therapeutic targets; Irreversible inhibitors; Repurposing drugs
Online: 8 November 2023 (16:11:55 CET)
ARTICLE
|
doi:10.20944/preprints202308.1047.v1
Subject:
Medicine And Pharmacology,
Ophthalmology
Keywords:
Age-related Macular Degeneration (AMD); Cornea; docosahexaenoic acid (DHA); drug delivery; non-invasive ocular delivery platform (NIODP); ocular disease; omega-3; retina; retinal delivery; retinal dis
Online: 14 August 2023 (15:18:22 CEST)
REVIEW
|
doi:10.20944/preprints201912.0386.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
resistance-associated secretory phenotype (RASP); extracellular vesicle (EV); exosome; oncosome; drug resistance; epithelial-mesenchymal transition (EMT); heat shock protein (HSP); cell stress response; hypoxia; acidosis; tumor immunology
Online: 29 December 2019 (13:46:21 CET)
REVIEW
|
doi:10.20944/preprints202401.1443.v1
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
The Blood-Brain Barrier (BBB); CNS drug discovery; passive diffusion; active transport; Efflux transporters; Influx Transporters; P-glycoproteins (P-gp); breast cancer resistance protein (BCRP); in silico models
Online: 19 January 2024 (09:32:31 CET)
ARTICLE
|
doi:10.20944/preprints202408.0031.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
EMA; DGDA; Drug Regulatory Authorities; Manufacturing Guidelines; Quality Medicine; Good Laboratory Practice; cGMP; GMP; GLP; IPQC; QC; QA; Quality Control; Quality Assurance; Current Good Manufacturing Practice; Good Manufacturing Practice
Online: 1 August 2024 (11:15:43 CEST)
REVIEW
|
doi:10.20944/preprints202305.1078.v1
Subject:
Chemistry And Materials Science,
Organic Chemistry
Keywords:
bacterial resistance; methicillin-resistant S. aureus (MRSA); multi drug resistant (MDR) bacteria; Cannabis sativa; phytocannabinoids (PCs); endocannabinois (ECs); synthetic cannabinoids (SCs); synthetic procedures; cannabichromene (CBC); cannabigerol (CBG); cannabidiol (CBC)
Online: 16 May 2023 (04:29:36 CEST)
REVIEW
|
doi:10.20944/preprints202305.0658.v1
Subject:
Chemistry And Materials Science,
Nanotechnology
Keywords:
Nanotechnology application; nano-suspension techniques; nano-emulsion techniques; bioactive constituents of plant; phytochemicals (PHYs); poor water solubility; drug delivery systems (DDSs); toxicological risks of NPs; clinical application of NPs
Online: 9 May 2023 (12:50:27 CEST)
ARTICLE
|
doi:10.20944/preprints202304.0625.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
adverse drug reaction; cisplatin liposomes; circulating tumor cells; enhanced permeability and retention effect; nephrotoxicity; pulmonary metastasis of pancreatic cancer; quality of life; recurrent liver metastases from primary nasal cancer
Online: 20 April 2023 (07:52:10 CEST)
REVIEW
|
doi:10.20944/preprints202407.1534.v1
Subject:
Medicine And Pharmacology,
Hematology
Keywords:
lymphoma; B‐cell; hematologic neoplasms; bruton tyrosine kinase; protein kinase inhibitors; drug resistance; neoplasm; ibrutinib; pirtobrutinib; molecular targeted therapy; chronic lymphocytic leukemia; hematopoietic stem cell transplantation; covalent inhibitors; protein degradation
Online: 18 July 2024 (17:24:05 CEST)
CASE REPORT
|
doi:10.20944/preprints202308.1373.v1
Subject:
Medicine And Pharmacology,
Hematology
Keywords:
Large B-cell lymphoma (LBCL); Immunohistochemical (IHC) staining; Glucoseregulated protein 94 (GRP94); CYP3A4; Multidrug resistance protein 1 (MDR1); Aldo-keto reductase family 1 member C3 (AKR1C3); Multi-drug resistance-associated protein 1 (MRP1); P53
Online: 18 August 2023 (11:42:22 CEST)
ARTICLE
|
doi:10.20944/preprints202410.0290.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
anti-microbial resistance; AMR; antibiotic resistance; ABR; drug-resistant bacteria; antibi-otic-resistant bacteria; multidrug resistance; MDR; host-directed therapy; EP67; complement peptide-derived immunostimulant; administration route; CPDI-02 toxicity; CPDI-02 dosing; IM dosing
Online: 4 October 2024 (08:12:03 CEST)
ARTICLE
|
doi:10.20944/preprints202401.0743.v1
Subject:
Medicine And Pharmacology,
Ophthalmology
Keywords:
Age-related macular degeneration (AMD); Anti-vascular endothelial growth factor (VEGF) treatment; Drug switch; Intravitreal aflibercept (IVA); Intravitreal faricimab (IVF); Macular neovascularization (MNV); Polypoidal choroidal vasculopathy (PCV); Real-world date; Refractory cases; Treat-and-extend (TAE) regimen
Online: 9 January 2024 (15:53:57 CET)
REVIEW
|
doi:10.20944/preprints202405.0500.v1
Subject:
Medicine And Pharmacology,
Gastroenterology And Hepatology
Keywords:
Gilbert’ s syndrome (GS), Genetic variations, Protective effects of Gilbert’ s syndrome, Cancer risk, Drug interactions, Pharmacokinetic abnormalities, Clinical implications of Gilbert’ s Syndrome, Effect on NASH, Liver transplantation, Psychology and GS
Online: 9 May 2024 (02:57:19 CEST)
REVIEW
|
doi:10.20944/preprints202406.0911.v1
Subject:
Engineering,
Transportation Science And Technology
Keywords:
RPAS (Remotely Piloted Aircraft Systems); Drones; Regulations; Medication Transport; INVIMA (National Institute for Food and Drug Surveillance); UAEAC (Special Administrative Unit of Civil Aeronautics); Safe and Quick Delivery; Cold Chain; Drone Delivery; Flight and Maintenance Log; Operations Manual; Manufacturer's Manual
Online: 13 June 2024 (09:55:59 CEST)
ARTICLE
|
doi:10.20944/preprints202406.0122.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Tissue agnostic drug development; Pembrolizumab; Microsatellite instability-high (MSI-H); Tumor mutational burden-high (TMB-H); Dostarlimab-gxly; Larotrectinib; Entrectinib; Neurotrophic tyrosine kinase (NTRK); Dabrafenib and trametinib; V-Raf Murine Sarcoma Viral Oncogene Homolog B V600E (BRAFV600E); Selpercatinib; Rearranged during transfection (RET); Precision oncology.
Online: 3 June 2024 (16:08:38 CEST)
ARTICLE
|
doi:10.20944/preprints201810.0088.v1
Subject:
Chemistry And Materials Science,
Biomaterials
Keywords:
There are many molecules used as drug carrier. TUD-1 is a newly synthesized mesoporous silica (SM) molecule possess two important features; consists of mesoporous so it is very suitable to be drug carrier in addition to that it has the ability to induce apoptosis in cancer cells. However, the effect of TUD-1 appears to act as cell death inducer, regardless of whether it is necrosis or apoptosis. Unfortunately, recent studies indicate that a proportion of cells undergo necrosis rather than apoptosis, which limits the use of TUD-1 as a secure treatment. On the other hand, lithium considered as necrosis inhibitor element. Hence, current study based on the idea of production a new Li/TUD-1 by incorporated mesoporous silica (TUD-1 type) with lithium in order to produce a new compound that has the ability to activate apoptosis by mesoporous silica (TUD-1 type) and at the same time can inhibit the activity of necrosis by lithium. Herein, lithium was incorporated in TUD-1 mesoporous silica by
Online: 4 October 2018 (15:54:02 CEST)