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Preprint COMMUNICATION | doi:10.20944/preprints202407.0131.v1

Evaluation of Neutralizing Antibodies on Respiratory Syncytial Virus in Japanese Mother-Infant Pairs after COVID-19 Pandemic

Tomohiro Oishi, Daisuke Yoshioka, Sachie Ono, Yuto Yasui, Atsushi Kato, Satoko Ogita, Tomoaki Tokutomi, Mazumi Miura, Takahiro Eitoku, Hideo Enoki, Koichiro Shimoya, Takashi Nakano

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Neutralizing antibodies, respiratory syncytial virus, mother,

Online: 2 July 2024 (00:19:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1024.v1

Screen and Character a New Iflavirus Virus in the Fruit Tree Pest Pyrops candelaria

Hong Lin, Weitao Song, Dongmei Ma, Chi Yang, Yanfang Yao, Renyi Liu, Ling Hao, Dandan Wu, Shihua Wang, Jimou Jiang, Jun Xiong, Rui Ma, Jiajing Xiao, Zhenhong Zhuang

Subject: Biology And Life Sciences, Insect Science Keywords: Iflavirus; Pyrops candelaria; virus; insect; distribution

Online: 14 June 2024 (16:08:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0481.v1

Oncolytic Tanapoxvirus Variants Expressing mIL-2 and mCCL-2 Regress Human Pancreatic Cancer Xenografts in Immunocompromised and Immune Reconstituted CAnN.Cg-Foxn1nu/Crl Nude Mice

Scott Haller, Karim Essani

Subject: Biology And Life Sciences, Virology Keywords: pancreatic cancer; tanapoxvirus; oncolytic virus; TPV

Online: 9 May 2024 (12:19:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0723.v1

Design of Lipid Nanoparticles of mRNA Vaccine against Respiratory Syncytial Virus by Bioinformatics in Egypt

Mohammed Kassab

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Respiratory syncytial virus; vaccine; mRNA; immunization

Online: 10 April 2024 (09:22:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0162.v1

Respiratory Syncytial Virus Vaccine mRNA Lipid Nanoparticles Pattern Determined via Bioinformatics

Mohammed Mahmoud Shawky Kassab

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Respiratory syncytial virus; vaccine; mRNA; immunization

Online: 2 April 2024 (05:38:35 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202401.1217.v1

Highlighting the Insights Surrounding the Recent Nipah Virus Outbreak in Kerala in 2023

Neelabh Datta

Subject: Biology And Life Sciences, Virology Keywords: Nipah virus; outbreak; epidemiology; insights; response

Online: 16 January 2024 (12:35:34 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.1642.v1

Shrews (Soricidae) and Viruses Identified in Shrews

Huan-Yu Gong, Rui-Xu Chen, Su-Mei Tan, Xiu Wang, Ji-Ming Chen, Yuan-Long Zhang, Ming Liao

Subject: Biology And Life Sciences, Virology Keywords: shrew; virus; diversity; domestic animal; human

Online: 21 December 2023 (10:25:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0692.v1

Japanese Encephalitis: Risk of Emergence in the United States and the Resulting Impact

Thomas P Monath

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Japanese encephalitis; emerging virus; risk management

Online: 11 December 2023 (15:05:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0241.v1

Isolation and Pathogenicity Analysis of a G5P[23] Porcine Rotavirus Strain

Liguo Gao, Hanqin Shen, Sucan Zhao, Sheng Chen, Puduo Zhu, Wencheng Lin, Feng Chen

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Porcine rotavirus; G5; Virus isolation; Pathogenicity

Online: 3 November 2023 (11:02:46 CET)

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Preprint REVIEW | doi:10.20944/preprints202307.1892.v1

Oncolytic Viruses and Immune Checkpoint Inhibitors: The “Hot” New Power Couple

Charlotte Lovatt, Alan L. Parker

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Oncolytic virus; immune checkpoint inhibitors; immunotherapy

Online: 28 July 2023 (10:58:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1208.v1

Oclacitinib and Myxoma Virus Therapy in Dogs with High Grade Soft Tissue Sarcoma

Laura Vari Ashton, Kristen M. Weishaar, Bernard Séguin, Amy Leone MacNeill

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cytokines; oclacitinib; oncolytic virus; dogs; cancer

Online: 18 July 2023 (10:10:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0961.v1

Overview of Mpox outbreak in Greece in 2022-2023; Is it over?

KASSIANI MELLOU, Kyriaki Tryfinopoulou, Styliani Pappa, Kassiani Gkolfinopoulou, Sofia Papanikou, Georgia Papadopoulou, Evaggelia Vassou, Evaggelia- Georgia Kostaki, Kalliopi Papadima, Elissavet Mouratidou, Maria Tsintziloni, Nikolaos Siafakas, Zoi Florou, Antigoni Katsoulidou, Spyros Sapounas, Georgios Sourvinos, Spyridon Pournaras, Efthimia Petinaki6, Vassilios Paparizos, Anna Papa, Theoklis Zaoutis, Dimitrios Paraskevis

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: mpox, virus, outbreak, response, vaccination; Orthopoxvirus

Online: 13 June 2023 (16:57:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1257.v1

Proposal Model for Evaluation of African/Asian/Brazilian-ZIKV Strains Viral Kinetics (Step Growth Curve) in Trophoblastic Cell Lines

Márcia Duarte-Barbosa, Anderson Costa, Paula Prieto-Oliveira, Robert Andreata-Santos, Cristina M. Peter, Paolo M. A. Zanotto, Luiz M. R. Janini

Subject: Biology And Life Sciences, Virology Keywords: Zika virus; Trophoblast cell; Viral kinetics

Online: 17 May 2023 (14:26:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0389.v1

Ebolavirus Species-Specific Interferon Antagonism Mediated by VP24

Palaniappan Ramanathan, Bersabeh Tigabu, Rodrigo Santos, Philipp Ilinykh, Natalia Kuzmina, Olivia Vogel, Naveen Thakur, Hamza Ahmed, Chao Wu, Gaya Amarasinghe, Christopher Basler, Alexander Bukreyev

Subject: Biology And Life Sciences, Virology Keywords: Ebola virus; VP24; immune evasion; STAT1

Online: 17 April 2023 (03:54:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0027.v1

Engineering Adenoviral Vectors With Improved GBM Selectivity

Emily A Bates, Charlotte Lovatt, Alice R Plein, James A Davies, Florian A. Siebzehnrubl, Alan L Parker

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: brain tumour; oncolytic virus; receptor; therapy

Online: 3 April 2023 (13:31:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0079.v1

Hepatitis C Core Protein Induces a Genotype-specific Susceptibility of Hepatocytes to TNF-induced Death in vitro and in vivo

Savvina Moustafa, Katerina Kassela, Maria Bampali, Nikolas Dovrolis, Athanassios Kakkanas, Apostolos Beloukas, Penelope Mavromara, Ioannis Karakasiliotis

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Hepatitis C virus; core protein; TNFα

Online: 6 September 2022 (03:38:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202112.0484.v1

Apoptosis During ZIKA Virus Infection: Too Soon or Too Late?

Jonathan Turpin, Daed El Safadi, Grégorie Lebeau, Morgane Krejbich, Camille Chatelain, Philippe Desprès, Wildriss Viranaicken, Pascale Krejbich-Trotot

Subject: Biology And Life Sciences, Virology Keywords: apoptosis; cell death; Zika virus; oncolytic

Online: 30 December 2021 (12:32:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0114.v1

Registration of Reactions Occurring From the Emergence of a Virus by Using an Electromagnetic Charge Effect

Ognyan Ivanov, Konstantin Simeonov, Petar Todorov, Desislava Antonova, Viktor Pulis

Subject: Physical Sciences, Acoustics Keywords: sensor; virus; detection; electromagnetic echo effect

Online: 4 December 2020 (14:36:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0100.v1

Serologically-based Evaluation of Cross-protection Antibody Responses Among Different A(H1N1) Influenza Strains

Serena Marchi, Ilaria Manini, Otfried Kistner, Pietro Piu, Edmond J. Remarque, Alessandro Manenti, Fabrizio Biuso, Tommaso Carli, Giacomo Lazzeri, Emanuele Montomoli, Claudia Maria Trombetta

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: influenza virus; H1N1; immunity; antigenic drift

Online: 5 October 2020 (17:24:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0061.v1

An Unconventional Flavivirus and other RNA Viruses in the Sea Cucumber (Holothuroidea; Echinodermata) Virome

Ian Hewson, Mitchell R. Johnson, Ian R. Tibbetts

Subject: Biology And Life Sciences, Virology Keywords: holothurian; Apostichopus; wasting; virus; flavivirus; totivirus

Online: 3 September 2020 (06:20:30 CEST)

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Working Paper ARTICLE

Delineating Blueprint of an Epitope-Based Peptide Vaccine against the Multiple Serovars of Dengue Virus: A Hierarchical Reverse Vaccinology Approach

Rahatul Islam, Md. Sorwer Alam Parvez, Saeed Anwar, Mohammad Jakir Hosen

Subject: Biology And Life Sciences, Virology Keywords: Dengue virus; multiple serovars; Epitopes; Vaccine

Online: 31 May 2020 (18:28:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202005.0410.v1

Corona Virus Disease 2019 (COVID-19) Pandemic Up-to-Date Facts, Opportunities and Challenges: A review on Cases in Ethiopia

Chanie Derso Misganaw

Subject: Biology And Life Sciences, Virology Keywords: coronavirus; prevention; species; symptom; virus origin

Online: 25 May 2020 (11:09:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0507.v1

Virus Graph and COVID-19 Pandemic: A Graph Theory Approach

H. R. Bhapkar, Parikshit Mahalle, Prashant S. Dhotre

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: virus graphs; COVID-19; pandemic; epidemic

Online: 29 April 2020 (12:32:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints201905.0273.v1

Influenza Management Prospects of Passive Immunotherapy

Erasmus Kotey, Deimante Lukosaityte, Osbourne Quaye, William Ampofo, Gordon Awandare, Munir Iqbal

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: influenza virus; vaccines; passive immunization; immunotherapeutics

Online: 22 May 2019 (11:31:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0626.v1

Cross-Reactive Antibodies to the NS1 Protein of Omsk Hemorrhagic Fever Virus Are Absent in the Sera of Patients with Tick-Borne Encephalitis

Bogdana I. Kravchuk, Yana A. Khlusevich, Galina S. Chicherina, Valeriy V. Yakimenko, Elena I. Krasnova, Nina V. Tikunova, Andrey L. Matveev

Subject: Biology And Life Sciences, Virology Keywords: NS1 protein; Omsk hemorrhagic fever virus; OHFV; tick-borne encephalitis virus; TBEV; Fla-viviruses; Flavivirus diagnosis.

Online: 9 May 2024 (17:21:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0877.v1

A Reliable Multifaceted Solution against Foodborne Viral Infections: The Case of RiLK1 Decapeptide

Emanuela Galatola, Bruna Agrillo, Marta Gogliettino, Gianna Palmieri, Serena Maccaroni, Teresa Vicenza, Yolande T.R. Proroga, Andrea Mancusi, Simona Di Pasquale, Elisabetta Suffredini, Loredana Cozzi

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Antimicrobial peptide; Enteroviruses; Non-enveloped virus; Virucidal activity; Foodborne viral infections; Hepatitis A Virus; Murine Norovirus

Online: 15 April 2024 (04:16:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.0686.v1

Screening for viruses in indigenous Greek black pigs

Hina Jhelum, Vasileios Papatsiros, Georgios Papakonstantinou, Ludwig Krabben, Benedikt Kaufer, Joachim Denner

Subject: Biology And Life Sciences, Virology Keywords: xenotransplantation; virus safety; porcine cytomegalovirus/porcine roseolovirus (PCMV/PRV); hepatitis E virus; porcine endogenous retroviruses (PERVs)

Online: 11 December 2023 (10:03:20 CET)

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Preprint REVIEW | doi:10.20944/preprints202307.1735.v1

Heartland Virus: An Evolving Story Of An Emerging Zoonotic And Vector-Borne Disease

Emily K. Mantlo, Nicholas J. Haley

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Heartland Virus; Bandavirus; Amblyomma americanum; Haemaphysalis longicornis; vector-borne disease; Severe Fever with Thrombocytopenia Syndrome Virus

Online: 26 July 2023 (10:23:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.0239.v1

Begomovirus-Host Interactions: Viral Proteins Orchestrating Intra and Intercellular Transport of Viral DNA while Suppressing Host Defense Mechanisms

Sâmera de S. Breves, Fredy A. Silva, Nívea C. Euclydes, Thainá F.F. Saia, James Jean-Baptiste, Eugenio R Andrade Neto, Elizabeth P. B. Fontes

Subject: Biology And Life Sciences, Plant Sciences Keywords: Begomoviruses; movement protein; nuclear shuttle protein; suppression of antiviral signaling; virus-host interactions; intracellular virus movement

Online: 4 July 2023 (13:46:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202211.0112.v1

Biothermodynamics of Viruses from Absolute Zero (1950) To – Virothermodynamics (2022)

Marko Popovic

Subject: Biology And Life Sciences, Virology Keywords: Thermodynamics; Calorimetry; Entropy; Enthalpy; Gibbs energy; Virus-host interaction; SARS-CoV-2; COVID-19; Ebola virus

Online: 7 November 2022 (08:41:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0240.v1

Potential Targets for Evaluation of Sugarcane Yellow Leaf Virus Resistance in Sugarcane Cultivars: In silico Sugarcane miRNA and Target Network Prediction

Muhammad Aleem Ashraf, Xiaoyan Feng, Linbo Shen, Shuzhen Zhang

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Gene Silencing; Host–Virus Interaction; RNA Interference; Saccharum officinarum; Sugarcane Yellow Leaf Virus and Target Prediction

Online: 14 September 2021 (12:43:22 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202102.0434.v1

Phenotypic Divergence of P Proteins of Australian Bat Lyssavirus Lineages Circulating in Microbats and Flying Foxes

Celine Deffrasnes, Meng-Xiao Luo, Linda Wiltzer, Cassandra T David, Kim G Lieu, Lin-Fa Wang, David A. Jans, Glenn A. Marsh, Gregory Moseley

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Australian bat lyssavirus; lyssavirus; rabies virus; immune evasion; nuclear trafficking; interferon; STAT1; bats; virus reservoirs; adaptation

Online: 19 February 2021 (10:06:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints201907.0246.v1

Historical H1N1 Influenza Virus Imprinting Increases Vaccination Efficacy by Influencing Antibody Longevity and Neutralization Activity in Ferrets

Magen E. Francis, Mara McNeil, Nicholas J. Dawe, Mary K. Foley, Morgan L. King, Ted M. Ross, Alyson A. Kelvin

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: influenza virus; imprinting; haemagglutinin; antibody titre; quadrivalent vaccine; influenza A; H1N1; split-virion; isotype; virus neutralization

Online: 23 July 2019 (04:03:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints201804.0009.v1

Applications of the FIV Model to Study HIV Pathogenesis

Craig Miller, Zaid Abdo, Aaron Ericsson, John Elder, Sue VandeWoude

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: feline immunodeficiency virus; FIV; human immunodeficiency virus; HIV; animal models, opportunistic disease, lentiviral pathogenesis; molecular biology

Online: 2 April 2018 (07:54:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0557.v1

Study of Viral Coinfection of the Ixodes Persulcatus Tickets Feeding on Humans in a Natural Foci of the South of the Far East

Galina Leonova, Larisa Somova, Svetlana Abramva, Evgeniy Pustovalov

Subject: Biology And Life Sciences, Virology Keywords: coinfection; tick Ixodes persulcatus; virus isolate; tick-borne encephalitis virus (TBEV); ectromelia virus; biological properties of co-isolate; electron microscopy; south of the Russian Far East

Online: 7 June 2023 (13:14:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202209.0482.v1

The Molecular Interplay between Human Oncoviruses and Telomerase in Cancer Development

Maria Lina Tornesello, Andrea Cerasuolo, Noemy Starita, Anna Lucia Tornesello, Patrizia Bonelli, Franca Maria Tuccillo, Luigi Buonaguro, Maria G Isaguliants, Franco M. Buonaguro

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Telomerase reverse transcriptase; TERT; TERT promoter; TERTp; human papillomavirus; HPV; Epstein Barr virus (EBV); Kaposi sarcoma-associated herpesvirus; HHV-8; hepatitis B virus; HBV; hepatitis C virus; HCV; human T-cell leukemia virus-1; HTLV-1

Online: 30 September 2022 (10:11:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0299.v1

Interactions of Human Dermal Dendritic Cells and Langerhans Cells Treated with Hyalomma Tick Saliva with Crimean-Congo Hemorrhagic Fever Virus

Sergio E. Rodriguez, Alexander J. McAuley, Aysen Gargili, Dennis A. Bente

Subject: Biology And Life Sciences, Virology Keywords: Crimean-Congo hemorrhagic fever virus; Crimean-Congo hemorrhagic fever; Hyalomma marginatum; human cutaneous immune response; Langerhans cells; dermal dendritic cells; tick-borne virus; tick-virus-host interface

Online: 19 June 2018 (11:50:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0910.v2

Social Determinants of Health (SDoH) and Hepatitis B and C Health Inequalities Among Male Prisoners in Nigeria: A Narrative Literature Review

Chidi Peter Onyemali, Damilola Kudirat Odemona, Salma Madihi

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Viral Hepatitis; Hepatitis B Virus (HBV); Hepatitis C Virus (HCV); Social Determinants of Health (SDoH); inadequate healthcare access; prevalence; food insecurity; marginalised population group and Nigerian prisons

Online: 23 September 2024 (12:45:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0482.v1

Establishment of a Suitable Diagnostic Pipeline to Ensure Sensitive Detection of African Swine Fever Virus Genome in Porcine Semen

Virginia Friedrichs, Darwin Reicks, Jeffrey J. Zimmerman, Eric A. Nelson, Carola Sauter-Louis, Martin Beer, Jane Christopher-Hennings, Sandra Blome

Subject: Biology And Life Sciences, Virology Keywords: African swine fever virus; virus diagnostics; boar semen; commercial qPCR kits; comparison; nucleic acid extraction; sensitivity; performance

Online: 8 May 2024 (09:38:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0809.v1

High Throughput Determination of Infectious Virus Titers by Kinetic Measurement of infection-Induced Changes in Cell Morphology

Dominik Hotter, Marco Kunzelmann, Franziska Kiefer, Chiara Leukhardt, Carolin Fackler, Stefan Jaeger, Johannes Solzin

Subject: Biology And Life Sciences, Virology Keywords: Infectious virus titer; kinetic imaging; cell rounding; infectivity assay; TCID50; ATMP; virus-based therapeutics; vaccine; high throughput

Online: 14 March 2024 (15:33:09 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202402.0696.v1

Investigating the Inhibitory Potential of Amentoflavone against HIV-1 Protease: A Molecular Docking Study

Ivan Vito Ferrari

Subject: Public Health And Healthcare, Other Keywords: HIV-1 protease 2; SWISS DOCK Server; Roussarcoma virus protease; Human Immunodeficiency Virus

Online: 13 February 2024 (08:13:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1992.v1

Genome-Wide Identification of Cotton MicroRNAs Predicted for Targeting Cotton Leaf Curl Kokhran Virus-Lucknow

Muhammad Aleem Ashraf, Judith K Brown, Muhammad Shahzad Iqbal, Naitong Yu

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Cotton leaf curl Kokhran virus; microRNAs; RNA interference; prediction; computational algorithms; target binding sites; host-virus interaction

Online: 28 September 2023 (18:36:58 CEST)

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Cotton leaf curl Kokhran virus (CLCuKoV) (genus, Begomovirus; family, Geminiviridae) is highly infectious, widespread and the most dangerous pathogen of cotton (Gossypium hirsutum L.) that is responsible to a serious disorder, cotton leaf curl disease (CLCuD). Begomoviruses are spread very efficiently by the whitefly Bemisia tabaci cryptic species, causing economic losses to cotton crop, all over the world. The ‘Lucknow’ strain of CLCuKoV has emerged as a divergent isolate that could cause CLCuD. The monopartite ssDNA genome of CLCuKoV-Lu (2.7 Kb) contains six open reading frames (ORFs) that was shown to encode four major proteins. RNA interference (RNAi)-based antiviral innate immunity is a sequence-specific biological phenomenon and a powerful tool to control plant viruses. The present study aims to determine cotton locus-derived microRNAs (ghr-miRNAs) that are identified for targeting the CLCuKoV-Lu ss-DNA-encoded mRNAs using a predictive approach that involves four computational algorithms, miRanda, RNA22, psRNATarget and RNAhybrid. Mature ghr-miRNA sequences (n=80) from allotetraploid upland cotton (2n = 4x = 52) were selected from the miRBase and were tested for alignment with the CLCuKoV-Lu genome. Among the 80 cotton locus-derived ghr-miRNAs evaluated, only one consensus cotton locus-derived ghr-miRNA (ghr-miR2950) was concluded to have effective ghr-miRNA target site at common nucleotide position 82 in the CLCuKoV-Lu genome respectively, using a stringent criterion, identified by all the algorithms used. The miRNA targeting is reliant on base pairing of miRNA-mRNA target pairings. Conservation of the hybridization binding site of the predicted ghr-miR2950 was validated using multiple sequence alignment within all the strains of CLCuKoV. We constructed a regulatory interaction network of miRNA–mRNA to identify novel targets. The efficacy of the predicted miRNAs against CLCuKoV-Lu was evaluated by RNAi-mediated targeted mRNA cleavage. The current investigated miRNA targets provide evidence for the development of CLCuD-resistant cotton plants.

Preprint REVIEW | doi:10.20944/preprints202002.0007.v1

CRISPR-Cas Systems for Diagnosing Infectious Diseases

Anastasiya Kostyusheva, Sergey Brezgin, Yurii Babin, Irina Vasil'eva, Dmitry Kostyushev, Vladimir Chulanov

Subject: Biology And Life Sciences, Virology Keywords: molecular diagnostics; molecular epidemiology; HIV; HBV; HCV; HPV; Zika virus; Dengue virus; tuberculosis; SARS; MERS; nCov-2019

Online: 3 February 2020 (03:47:27 CET)

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Infectious diseases are a global health problem affecting billions of people. Developing rapid and sensitive diagnostic tools is key for successful patient management and curbing disease spread. Currently available diagnostics are very specific and sensitive but time-consuming and require expensive laboratory settings and well-trained personnel; thus, they are not available in resource-limited areas, for the purposes of large-scale screenings and in case of outbreaks and epidemics. Developing new, rapid, and affordable point-of-care diagnostic assays is urgently needed. This review focuses on CRISPR-based technologies and their perspectives to become platforms for point-of-care nucleic acid detection methods and as deployable diagnostic platforms that could help to identify and curb outbreaks and emerging epidemics. We describe the mechanisms and function of different classes and types of CRISPR-Cas systems, including pros and cons for developing molecular diagnostic tests and applications of each type to detect a wide range of infectious agents. Many Cas proteins (Cas9, Cas12, Cas13, Cas14) have been leveraged to create highly accurate and sensitive diagnostic tools combined with technologies of signal amplification and fluorescent, potentiometric, colorimetric, or lateral flow assay detection. In particular, the most advanced platforms -- SHERLOCK/v2, DETECTR, or CRISPR-Chip -- enable detection of attomolar amounts of pathogenic nucleic acids with specificity comparable to that of PCR but with minimal technical settings. Further developing CRISPR-based diagnostic tools promises to dramatically transform molecular diagnostics, making them easily affordable and accessible virtually anywhere in the world. The burden of socially significant diseases, frequent outbreaks, recent epidemics (MERS, SARS and the ongoing coronoviral nCov-2019 infection) urgently need the developing of express-diagnostic tools. Recently devised CRISPR-technologies represent the unprecedented opportunity to reshape epidemiological surveillance and molecular diagnostics.

Preprint ARTICLE | doi:10.20944/preprints201901.0157.v1

Cetacean Morbillivirus, a Journey from Land to Sea and viceversa

Giovanni Di Guardo, Sandro Mazzariol

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: Cetacean Morbillivirus; Canine Distemper Virus; Rinderpest Virus; viral phylogeny; viral evolution; Host-pathogen interactions; cetaceans; aquatic mammals

Online: 16 January 2019 (08:38:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202410.0768.v1

Meta-Analysis on the Age-Specific Seroprevalence of Hepatitis A Virus in Turkey

Ihsan Hakki Ciftci, Mehmet Koroglu, Tayfur Demiray, Huseyin Agah Terzi, Elmas Pinar Kahraman Kilbas

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Hepatitis A virus; Meta analysis; Seroprevalence; Turkey

Online: 10 October 2024 (09:39:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0981.v1

Prevalence, Characteristics, and Distribution of Human Papillomavirus According to Age and HIV Status in Women of Eastern Cape Province, South Africa

Zizipho Z. A. Mbulawa, Sinazo Kondlo, Sinalo Toni, Lindiwe M Faye, Charles B Businge

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: human papillomavirus; human immunodeficiency virus; age; women

Online: 12 September 2024 (11:36:35 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202409.0080.v1

Potential Inhibitory Role of Amentoflavone Against Ebola Virus VP24 Structure: Insights from Docking Results

Ivan Vito Ferrari

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Ebola virus; docking simulations; Autodock Vina; Amentoflavone

Online: 2 September 2024 (09:58:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.2145.v1

Viruses Identified in Shrews (Soricidae) and Their Biomedical Significance

Huan-Yu Gong, Rui-Xu Chen, Su-Mei Tan, Xiu Wang, Ji-Ming Chen, Yuan-Long Zhang, Ming Liao

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: shrew; virus; diversity; public health; epidemiology; risk

Online: 29 August 2024 (12:13:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0541.v1

Evaluating Atlantic Salmon (Salmo salar) as a Natural or Alternative Host for Piscine Myocarditis Virus (PMCV) Infection

Ingvild B. Nyman, Øystein Wessel, Håvard Bjørgen, Marta Alarcon, Torstein Tengs, Espen Rimstad

Subject: Biology And Life Sciences, Aquatic Science Keywords: piscine myocarditis virus (PMCV); Salmo salar; Totivirus

Online: 8 July 2024 (15:07:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0734.v1

Isolation and Molecular Detection of Pigeon Pox Virus in a Pigeon with Both Cutaneous and Diphtheritic Forms of Pigeon Pox in Ghana

Richard Kwamena Abbiw, Kingsley Kwabena Amoako, Ben Enyetornye, Theophilus Odoom, Pius Agyenim Boateng, Stacy Magdaline Abbang, Collins Misita Moranga, Nana Yaw Tawiah-Yingar, Patrick Tetteh Ababio, Godwin Dogbey, Richard Suu-Ire, Osbourne Quaye

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: Pigeon pox; Pigeonpox virus; Bollinger bodies; Ghana

Online: 11 June 2024 (18:33:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.1523.v2

Highs and Lows in Calicivirus Reverse Genetics

Ángel L. Álvarez, Aroa Arboleya, Fábio A. Abade dos Santos, Alberto García-Manso, Inés Nicieza, Kevin P. Dalton, Francisco Parra, José M. Martín-Alonso

Subject: Biology And Life Sciences, Virology Keywords: calicivirus; reverse genetics; infectious clone; RNA virus

Online: 17 May 2024 (15:38:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0368.v1

Purpureocillum lilacinum Plant Growth-Promoting Fungi

Everlon Cid Rigobelo, Daniel Nicodemo, Olubukola Oluranti Babalola, Nicolas Desoignies

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: phosphorous solubilizing; yield increasing; tobacco virus; tomatoes

Online: 7 May 2024 (10:33:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1589.v1

Recombinant Fowlpox Virus fpIBD1 in Chicken’s Skin: Persistence and the Local Immune Response at the Site of Inoculation

Ibrahim Eldaghayes, Lisa Rothwell, Michael Skinner, Pete Kaiser

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Fowlpox virus; fpIBD1; immune cells; vaccination; persistence

Online: 26 March 2024 (11:45:15 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.1182.v1

Present and Future Applications of Digital PCR in Infectious Diseases Diagnosis

Laura Sancha Domínguez, Ana Cotos Suárez, María Sánchez Ledesma, Juan Luis Muñoz Bellido

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: dPCR; digital PCR; infection; bacteria; virus; parasites

Online: 20 March 2024 (08:24:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1093.v1

Detection of Human Adenovirus and Rotavirus in Untreated Wastewater in Lusaka, Zambia: Opportunity for Establishment of Wastewater Surveillance System for the Community

Ngonda Saasa, Ethel M’kandawire, Joseph Ndebe, Mulenga Mwenda, Fred Chimpukutu, Andrew Nalishuwa Mukubesa, Fred Njobvu, Doreen Mainza Shempela, Jay Sikalima, Carol Chiyesu, Bruce Muvwanga, Sarah M. Nampokolwe, Clement Sulwe, Thokozile Khondiwa, Todd Jennings, Ameck Kamanga, Edgar Simulundu, Conceptor Mulube, Wizaso Mwasinga, Jelaimo Mumeka, John Simwanza, Patrick Sakubita, Otridah Kapona, Chilufya Susan Aneta Mulenga, Musole Chipoya, Kunda Musonda, Nathan Kapata, Nyambe Sinyange, Muzala Kapina, Joyce Siwila, Misheck Shawa, Masahiro Kajihara, Ayato Takada, Hirofumi Sawa, Simulyamana A. Choonga, Roma Chilengi, Earnest Muyunda, King S. Nalubamba, Bernard M. Hang’ombe

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Wastewater; Adenovirus; Rotavirus; Enteric virus; concentration methods

Online: 19 March 2024 (05:18:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0812.v1

An Efficient Trans Complementation System for In Vivo Replication of Defective Poliovirus Mutants

Minetaro Arita

Subject: Biology And Life Sciences, Virology Keywords: Engineered cells; virus; trans complementation; picornavirus; enterovirus

Online: 14 March 2024 (11:11:53 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202402.0071.v1

Assessment of Performance and Comparison of Three Commercial HDV RNA Detection Assays: Implications for Diagnosis and Treatment Monitoring

Marta Illescas-López, Lucía Chaves-Blanco, Adolfo De Salazar, Melisa Hernández-Febles, Raquel Carracedo, Eduardo Lagarejos, Ana Fuentes, Sara Pereira, María Cea, Alberto De La Iglesia, Carolina Freyre-Carrillo, Asunción Iborra, María del Valle Odero Bernal, Aurora García-Barrionuevo, Antonio Aguilera, María José Pena, Federico García

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: hepatitis delta virus; molecular diagnosis; viral hepatitis

Online: 1 February 2024 (13:19:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.2043.v1

Passenger Routing Algorithm for COVID-19 Spreading Prevention by Minimising Overcrowding

Dimitrios Tolikas, Evangelos Spyrou, Vasileios Kappatos

Subject: Computer Science And Mathematics, Computer Science Keywords: routing; weight; COVID-19; overcrowding; virus; passenger

Online: 27 December 2023 (10:09:16 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0514.v1

Macrophage polarization in infectious diseases: PAMP, viru-lence factors, immune signaling and receptors

Cláudio Daniel Cerdeira, Maísa R.P.L. Brigagão

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Macrophage; polarization; receptor; bacteria; virus; fungi; parasites

Online: 8 December 2023 (07:39:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1487.v1

Simultaneous Detection of Three Subgroups of Avian Leukosis Virus Using the Nanoparticle-Assisted PCR Assay

Miaoli Wu, Shuaiqi Hu, Yujun Zhu, Feng Cong, Shengwang Liu

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: nanoPCR; avian leukosis virus; ALV-J; detection

Online: 22 September 2023 (04:33:14 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202309.0211.v1

Long-Term Organ Complications: The True Public Health Concern in SARSCoV-2 Infection

Ronald palacios castrillo

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: SARSCoV-2 virus; Long Covid; Spike protein

Online: 5 September 2023 (05:11:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.1127.v1

A Survey Of Henipavirus Tropism—Our Current Understanding From A Species/Organ And Cellular Level

Sandra Diederich, Shawn Babiuk, Hani Boshra

Subject: Biology And Life Sciences, Virology Keywords: tropism; henipavirus; rna virus; vaccine; animal models

Online: 15 August 2023 (11:49:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0100.v1

Evidence for distinct mechanisms of immune suppression in EBV-positive and EBV-negative Hodgkin lymphoma

Makka Adam, Yonas Bekueretsion, Amha Gebremedhin, Anna Kwiecinska, Rawleigh Howe, Beyene Petros, Mats Jerkeman

Subject: Medicine And Pharmacology, Hematology Keywords: Epstein Barr Virus, HL microenvironment, Immune suppression

Online: 2 August 2023 (05:14:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1265.v1

Unique Evolution Patterns of Hepatitis B and C Viruses Revealed by Continuous Genetic Surveillance from 2015 to 2021 in Gabon, Central Africa

Haruka Abe, Yuri Ushijima, Rodrigue Bikangui, Georgelin Nguema Ondo, Christelle M. Pemba, Vahid R. Zadeh, Patrick I. Mpingabo, Hayato Ueda, Selidji T. Agnandji, Bertrand Lell, Jiro Yasuda

Subject: Biology And Life Sciences, Virology Keywords: hepatitis virus; HBV; HCV; surveillance; Gabon; Africa

Online: 19 July 2023 (08:09:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1646.v1

Development and Validation of an Enzyme-Linked Immunosorbent Assay-Based Protocol for Evaluation of Respiratory Syncytial Virus Vaccines

Eliel Nham, A-Yeung Jang, Hyun Jung Ji, Ki Bum Ahn, Joon-Yong Bae, Man-Seong Park, Hakjun Hyun, Jin Gu Yoon, Hye Seong, Ji Yun Noh, Hee Jin Cheong, Woo Joo Kim, Ho Seong Seo, Joon Young Song

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: respiratory syncytial virus; RSV; ELISA; Vaccine; Immunogenicity

Online: 23 June 2023 (08:36:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0906.v1

Sera of Rats Fed With Baicalein Showed Effective Against Dengue Virus Replication

Ehsan Moghaddam, Keivan Zandi, Rafidah Lani, Didi Erwandi, Zamri Chik, Sazaly Abu Bakar, Pouya Hassandarvish

Subject: Biology And Life Sciences, Virology Keywords: Infectious Diseases; Arboviruses; Dengue Virus; Baicalin; Baicalein

Online: 13 June 2023 (08:49:48 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202305.1014.v1

Emergence of a New Strain of DENV-2 in South America: Introduction of the Cosmopolitan Genotype through the Brazilian-Peruvian Border

Murilo Tavares Amorim, Leonardo H. Almeida Hernández, Felipe Gomes Naveca, Ivy Tsuya Essashika Prazeres, Ana Lucia Monteiro Wanzeller, Eliana Vieira Pinto da Silva, Livia M. Neves Casseb, Fábio Silva Da Silva, Sandro Patroca da Silva, Bruno Tardelli Diniz Nunes, Ana Cecilia Ribeiro Cruz

Subject: Biology And Life Sciences, Virology Keywords: arboviruses; dengue virus serotype 2; Cosmopolitan genotype

Online: 15 May 2023 (10:00:46 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202305.0087.v1

Recent Population Dynamics of Japanese Encephalitis Virus

Jinpeng Xu, Abdul Wahaab, Sawar Khan, Mohsin Nawaz, Muhammad Naveed Anwar, Ke Liu, Jianchao Wei, Muddassar Hameed, Zhiyong Ma

Subject: Biology And Life Sciences, Virology Keywords: Japanese encephalitis virus; Population dynamic; Genetic diversity

Online: 2 May 2023 (11:02:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202303.0080.v1

Novel Bacteriophage-Based Food Packaging: An Innovative Food Safety Approach

Rajesh V. Wagh, Ruchir Priyadarshi, Jong-Whan Rhim

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Virus-fortification; antimicrobial; active packaging films; bacteriophages

Online: 6 March 2023 (02:20:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0052.v1

Molecular Tracking of The Origin of Vesicular Stomatitis Outbreaks in 2004 and 2018, Ecuador

David Vasco-Julio, Dayana Aguilar, Alexander Maldonado, Euclides De la Torre, Maria Soledad Cisneros-Montufar, Carlos Bastidas-Caldes, Juan-Carlos Navarro, Jacobus H. De Waard

Subject: Biology And Life Sciences, Virology Keywords: vesicular stomatitis virus; molecular epidemiology; outbreak; phylogeny

Online: 4 January 2023 (03:16:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0003.v1

Knowledge, Attitude, and Practices toward Hepatitis B Infection among Healthcare Students; A Nationwide Cross-Sectional Study in Jordan.

Nader Alaridah, Rayan M. Joudeh, Haneen Al-Abdallat, Raba’a F. Jarrar, Layan Ismail, Mohammad Jum’ah, Zaina S Alnajjar, Eman Alzyoud, Zaina Battah, Aya Battah, Manar Alshami, Anas H. A. Abu-Humaidan

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Hepatitis B Virus; Knowledge; Attitude; Practice; Jordan

Online: 3 January 2023 (04:33:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0256.v1

Repeated Intravaginal Inoculation of Zika Virus Protects Cynomolgus Monkeys from Subcutaneous Superchallenge

Maya Shofa, Tomotaka Okamura, Emiko Urano, Yasuhiro Yasutomi, Yoshiharu Matsuura, Akatsuki Saito

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Zika virus; intravaginal infection; superchallenge; neutralizing antibody

Online: 18 October 2022 (07:45:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202210.0154.v1

The Immune Microenvironment in Epstein–Barr Virus-Positive Gastric Cancer: Current Status and Future Perspectives

Keran Sun, Jingyuan Ning, Xiuli Wang, Xiao-Bing Chen

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Epstein–Barr virus; gastric cancer; immune microenvironment

Online: 11 October 2022 (10:43:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0341.v1

Regulation and Impact of Hepatitis B x Protein in Persistence and Oncogenesis of Hepatitis B Virus

Garima Garg, Shashank Purwar, Anirudh K. Singh, Ashish Kumar Vyas

Subject: Biology And Life Sciences, Virology Keywords: Hepatitis B Virus; Chronic Hepatitis infection; Oncogenesis

Online: 22 July 2022 (13:18:26 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202204.0071.v1

First Disease and the Great Imitator: A Diagnostic Dilemma with Ancient Maladies

Hisham Ahmed Imad, Ploi Lakanavisid, Phimphan Pisutsan, Kentaro Trerattanavong, Thundon Ngamprasertchai, Wasin Matsee, Watcharapong Piyaphanee, Pornsawan Leaungwutiwong, Wang Nguitragool, Emi E. Nakayama, Tatsuo Shioda

Subject: Biology And Life Sciences, Virology Keywords: measles virus; exanthema; Treponema pallidum; secondary syphilis

Online: 8 April 2022 (04:16:55 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202104.0122.v1

Gastrointestinal Manifestation of Severe SARS-CoV-2 Infection in an Immunocompromised Dog

Elizabeth M. Lennon, Alfonso Oceguera, Eli Braun, Stephen D. Cole, Nolan V. Chalifoux, Jillian Whelan, Nuala Meyer, Kimberly Slensky, Andreanne Cleroux, Susan R. Weiss, Una O'Doherty, Shelley C. Rankin

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: SARS-CoV-2; canine; gastrointestinal; infection; virus

Online: 5 April 2021 (12:23:45 CEST)

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Working Paper ARTICLE

Phosphoinositide 3’ Kinase γ Facilitates Polyomavirus Infection

Paul Clark, Gretchen V. Gee, Brandon S. Albright, Benedetta Assetta, Ying Han, Walter J. Atwood, Daniel DiMaio

Subject: Biology And Life Sciences, Virology Keywords: JC virus; polyomavirus; SV40; progressive multifocal leukoencephalopathy

Online: 20 September 2020 (14:08:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202008.0658.v1

Oncolytic Virotherapy in Glioma Tumors

Rius-Rocabert Sergio, Noemí García-Romero, Antonia García Fernández, Ayuso-Sacido Angel, Nistal-Villan Estanislao

Subject: Biology And Life Sciences, Virology Keywords: glioma; oncolytic virus; glioblastoma; virotherapy; brain tumor

Online: 30 August 2020 (11:17:24 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202008.0426.v1

Why Does Sars-Cov-2 Survive Longer on Plastic Than on Paper?

Denis CORPET

Subject: Biology And Life Sciences, Virology Keywords: enveloped virus, coronavirus, inactivation, persistence, surface, mechanisms

Online: 20 August 2020 (05:38:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0549.v1

Pandemic of Coronavirus (COVID-19) in Saudi Arabia

Maryam Ahmed Awaji

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Corona virus: COVID-19; Saudi Arabia; pandemic

Online: 23 July 2020 (11:32:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0314.v1

HERV and Epstein-Barr Virus: Another Piece to Multiple Sclerosis Puzzle

Letícia Caroline Breis, Marco Antônio Machado Schlindwein, Marcus Vinicius Magno Gonçalves

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Multiple Sclerosis; HERV; MSRV; Epstein Barr Virus

Online: 19 April 2020 (02:36:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0441.v1

Whole Virus Detection using Paper Potentiometry

Massood Tabib-Azar, Subhashish Dolai

Subject: Engineering, Electrical And Electronic Engineering Keywords: Paper based sensor; whole virus; Zika; Aptamer

Online: 28 February 2020 (13:30:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0291.v1

Whole Virus Detection Using Paper Potentiometry and Aptamers

Subhashish Dolai, Massood Tabib-Azar

Subject: Engineering, Bioengineering Keywords: paper based sensor; whole virus; Zika; aptamer

Online: 20 February 2020 (07:24:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0132.v2

SNV Reoccurrence in Multiple Regions in the Genome of 2019-nCoV

Xinjun He, Wei Yue, Jun Yan

Subject: Biology And Life Sciences, Virology Keywords: 2019-nCoV; SARS-CoV-2; novel corona virus; Wuhan pneumonia

Online: 18 February 2020 (11:52:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints201907.0161.v1

Updated Phylogeny of Chikungunya Virus Reveals Lineage-Specific RNA Architecture

Adriano de Bernardi Schneider, Roman Ochsenreiter, Reilly Hostager, Ivo L. Hofacker, Daniel Janies, Michael T. Wolfinger

Subject: Biology And Life Sciences, Virology Keywords: RNA virus; evolution; epidemics; phylogeography; secondary structure

Online: 11 July 2019 (15:31:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0356.v1

Towards Dewetting Monoclonal Antibodies for Therapeutical Purposes

Arturo Tozzi

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Influenza A virus, immunology, immunotherapy, receptor; tumors

Online: 29 May 2019 (16:16:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201902.0140.v1

Identification of a Novel Picorna-Like Virus, Burpengary Virus, That Is Negatively Associated with Chlamydial Disease in the Koala

Erin Harvey, Danielle Madden, Adam Polkinghorne, Edward C. Holmes

Subject: Biology And Life Sciences, Virology Keywords: virus discovery; Chlamydia pecorum; Koala; picornavirus; phylogeny

Online: 15 February 2019 (07:33:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0201.v1

Screening for Viral Hepatitis and Other Infectious Diseases in a High-Risk Health Care Group in Mexico

Oscar Lenin Ramírez-Pérez, Vania César Cruz-Ramon, Paulina Chinchilla-López, Héctor Baptista-González, Rocío Trueba-Gómez, Fany Rosenfeld-Mann, Elsa Roque-Álvarez, Nancy Edith Aguilar-Olivos, Guadalupe Ponciano-Rodriguez, Carlos Esteban Coronel-Castillo, Jocelyn Contreras-Carmona, Nahum Méndez-Sánchez

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: hepatitis c viruses; hepatitis e virus; dentists

Online: 10 October 2018 (05:21:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0359.v1

Host-Directed Antivirals: a Realistic Alternative to Fight Zika Virus

Juan-Carlos Saiz, Nereida Jiménez de Oya, Ana-Belén Blázquez, Estela Escribano-Romero, Miguel A. Martín-Acebes

Subject: Biology And Life Sciences, Virology Keywords: flavivirus; Zika virus; therapy; host-directed antivirals

Online: 19 July 2018 (11:45:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0278.v1

Expansion of the Metazoan Virosphere: Progress, Pitfalls, and Prospects

Darren J. Obbard

Subject: Biology And Life Sciences, Virology Keywords: virus; metagenomic; RNAi; host-range; picornavirales; drosophila

Online: 21 May 2018 (13:18:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0279.v1

A Virus in American Blackcurrant (Ribes americanum) with Distinct Genome Features Reshapes Classification in the Tymovirales

Thanuja Thekke-Veetil, Thien Ho, Joseph D. Postman, Robert R. Martin, Ioannis E. Tzanetakis

Subject: Biology And Life Sciences, Virology Keywords: Betaflexiviridae; blackcurrant; blackcurrant virus A; characterization; detection

Online: 23 April 2018 (10:37:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints201801.0120.v1

Responsive Polydiacetylene Vesicles for Biosensing Microorganisms

Estelle Lebègue, Carole Farre, Catherine Jose, Joelle Saulnier, Florence Lagarde, Yves Chevalier, Carole Chaix, Nicole Jaffrezic-Renault

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: vesicles; polydiacetylene; biosensing; bacteria; toxins; virus; peptides

Online: 15 January 2018 (07:44:02 CET)

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Preprint REVIEW | doi:10.20944/preprints201703.0118.v1

Potential Antivirals: Natural Products Targeting Replication Enzymes of Dengue and Chikungunya Viruses

Ana Flávia Costa da Silveira Oliveira, Róbson Ricardo Teixeira, André Silva de Oliveira, Ana Paula Martins de Souza, Milene Lopes da Silva, Sérgio Oliveira de Paula

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: dengue; chikungunya; virus enzymes; antiviral; natural products

Online: 16 March 2017 (09:42:52 CET)

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Preprint SHORT NOTE | doi:10.20944/preprints202303.0553.v2

The A(H5N1) Avian Influenza Virus at the Domestic Animal-Wildlife-Human Interface: Issues of Concern

Giovanni Di Guardo

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: A(H5N1) avian influenza virus; Influenza viruses; Virus host range; Zoonotic risk, Human exposure risk; Viral infection; Epidemiology

Online: 4 April 2023 (14:22:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0229.v1

It Takes Two to Tango; A Review of Oncogenic Virus and Host Microbiome Associated Inflammation on Head and Neck Cancer

Mallory G. McKeon, Jean-Nicolas Gallant, Young J. Kim, Suman R. Das

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: pharynx; oncogenic virus; oropharyngeal cancer; nasopharyngeal cancer; human papillomavirus (HPV); Epstein–Barr virus (EBV); microbiome; infection; inflammation; carcinogenesis

Online: 16 June 2022 (04:27:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201910.0161.v1

Enterovirus 71 Represses Interleukin Enhancer Binding Factor 2 Production and Nucleus Translocation to Antagonize ILF2 Antiviral Effects

Jing Jin, Wenbiao Wang, Sha Ai, Qi Zhang, Kailang Wu, Yingle Liu, Jianguo Wu

Subject: Biology And Life Sciences, Virology Keywords: Enterovirus 71; EV71; EV71 non-structural protein 2B; interleukin enhancer binding factor 2; ILF2; virus infection; virus replication

Online: 15 October 2019 (05:37:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201902.0062.v1

Spatiotemporal Heterogeneity in the Distribution of Chikungunya and Zika Virus Case Incidences and Risk Factors during their Epidemics in Barranquilla, Colombia, between 2014 and 2016: An Ecological Study.

Thomas C McHale, Claudia M Romero-Vivas, Claudio Fronterre, Pedro Arango-Padilla, Andrew K Falconar, Naomi R Waterlow, Chad Nix, Jorge Cano

Subject: Biology And Life Sciences, Virology Keywords: Chikungunya virus, Zika virus, spatial clustering, Bayesian Poisson models, conditional autoregressive models, socioeconomic risk factors, environmental risk factors

Online: 6 February 2019 (13:16:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints201902.0054.v1

Spatiotemporal Heterogeneity in the Distribution of Chikungunya and Zika Virus Case Incidences and Risk Factors During Their Epidemics in Barranquilla, Colombia, between 2014 and 2016: An Ecological Study

Thomas C. McHale, Claudia M. Romero-Vivas, Claudio Fronterre, Pedro Arango-Padilla, Andrew K. Falconar, Naomi R. Waterlow, Chad Nix, Jorge Cano

Subject: Biology And Life Sciences, Virology Keywords: Chikungunya virus, Zika virus, spatial clustering, Bayesian Poisson models, conditional autoregressive models, socioeconomic risk factors, environmental risk factors

Online: 5 February 2019 (14:25:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints201808.0030.v1

Improved Immune Responses against Zika Virus after Sequential Dengue and Zika Virus Infection in Human

Felix G. Delgado, Karina I. Torres, Jaime E. Castellanos, Consuelo Romero-Sánchez, Etienne Simon-Lorière, Anavaj Sakuntabhai, Claude Roth

Subject: Biology And Life Sciences, Virology Keywords: Dengue virus; Zika virus; T-cell epitopes; cross-reactive T cells; immunodominance; neutralizing antibodies; antibody-dependent-enhancement (ADE)

Online: 2 August 2018 (05:04:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.0185.v2

Antibody Dependent Enhancement (ADE) of Infection into Macrophages Validates the Importance of HERV-K102 Particle Production for Pandemic Preparedness

Marian Laderoute

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: ADE; HERV-K102; HERV-K HML-2; immunosenescence; foamy macrophages; virus-anti-virus; pandemic preparedness; mRNA COVID-19 vaccines; alpha-fetoprotein antagonists; virus strategies; anti-viral; trained (innate) immunity

Online: 20 August 2024 (05:07:06 CEST)

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