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Preprint ARTICLE | doi:10.20944/preprints202308.1583.v1

The Shortening of Leukocyte Telomere Length Contributes to Alzheimer’s Disease: Further Evidence from Late-Onset Familial and Sporadic Cases

Paolina Crocco, Francesco De Rango, Serena Dato, Rossella La Grotta, Raffaele Maletta, Amalia Cecilia Bruni, Giuseppe Passarino, Giuseppina Rose

Subject: Biology And Life Sciences, Aging Keywords: Telomere length; Telomeres; Alzheimer’s Disease; late-onset AD, Aging, Neurodegeneration

Online: 22 August 2023 (13:22:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0824.v1

A Biopsychosocial Model Predicting Myocardial Infarction

José M. Tomás, Amparo Oliver, Zaira Torres, Janhavi Parker, Elena Marques, Trinidad Sentandreu-Mañó

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: biopsychosocial approach; coronary artery disease; cardiovascular disease; SHARE survey; aging

Online: 10 August 2023 (08:14:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0306.v1

Vision impairments in young adults with Down syndrome

Yolanda Martin-Perez, Guadalupe Gonalez-Montero, Angel Luis Gutierrez-Hernandez, Vanesa Blázquez-Sánchez, Celia Sánchez-Ramos

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: aging; Down syndrome; quality of life; refractive error; visual impairments

Online: 3 August 2023 (10:27:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1589.v1

Replicative Senescence in Vascular Smooth Muscle Cells: PURPL and NEAT1 Long Non-Coding RNAs as New Senescence-Associated Biomarkers

Clara Rossi, Marco Venturin, Jakub Gubala, Angelisa Frasca, Alberto Corsini, Cristina Battaglia, Stefano Bellosta

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: aging; biomarkers; lncRNA; NEAT1; PURPL; RRAD; senescence; smooth muscle cells

Online: 24 July 2023 (10:02:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.1412.v1

Hydrogen Assisted Aging to Storage & Sealing Materials: A Comprehensive Review

A.K.M. Ahsanul Habib, Ahmed Nazmus Sakib, Zarin Tasnim Mona, Md Monjur Hossain Bhuiyan, Pejman Kazempoor, Zahed Siddique

Subject: Engineering, Chemical Engineering Keywords: hydrogen; aging; polymer; storage and sealing materials; sustainability; pipeline; leak

Online: 20 July 2023 (10:11:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1294.v1

The Mediating Effects of Social Networks and Wisdom on the Relationship between Lifestyle Habits and Healthy Aging in Older Adults with Chronic Diseases

Hee-Kyung Kim, Hye-Suk Oh, Cheol-Hee Park

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: elderly; healthy aging; lifestyle habits; social networks; wisdom; chronic disease

Online: 19 July 2023 (09:53:15 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202307.1015.v1

Short-Term Effects of Dietary Protein Supplementation on Physical Recovery in Older Patients at Risk of Malnutrition during Inpatient Rehabilitation: A Randomized Controlled Trial

Barbara Strasser, Vincent Grote, Walter Bily, Helena Nics, Patricia Riedl, Ines Jira, Michael J. Fischer

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: aging; dietary protein; hand-grip strength; physical function; rehabilitation; sarcopenia

Online: 14 July 2023 (11:32:28 CEST)

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It is estimated that about 50% of geriatric rehabilitation patients suffer from sarcopenia. Thereby, malnutrition is frequently associated with sarcopenia and dietary intake is the main modifiable risk factor. During hospitalization, older adults are recommended to consume more dietary protein than the current recommended dietary allowance of 0.8 g/kg body weight per day to optimize the recovery of muscular strength and physical function. This prospective study examined the effect of a short-term protein supplementation with protein-enriched foods and drinks on hand-grip strength, nutritional status and physical function in older patients at risk of malnutrition during a three week inpatient orthopedic rehabilitation stay. The Mini Nutritional Assessment (MNA) was used to assess malnutrition. Patients with a MNA score ≤ 23.5 points were randomly assigned to an intervention group (goal: to consume 1.2–1.5 g protein/kg body weight per day) or a control group (standard care). Both groups carried out the same rehabilitation program. Physical recovery parameters were determined at admission and discharge. There was a trend for participants in the intervention group to consume more protein than the control group (P = 0.058): 95.3 (SD 13.2) g/day as compared to 77.2 (SD 24.2) g/day, which corresponds to a mean protein intake of 1.6 (SD 0.3) g/kg/day vs. 1.3 (SD 0.5) g/kg/day. Dietary protein supplementation increased body weight by an average of 0.9 (SD 1.1) kg and fat mass by an average of 0.9 (SD 1.2) kg as compared with baseline (P = 0.039 and P = 0.050, respectively). There was no significant change in hand-grip strength, body composition and physical function. In conclusion, a short-term intervention with protein-enriched foods and drinks enabled older patients at risk of malnutrition to increase their protein intake to levels that are higher than their required intake. In these older individuals with appropriate protein intake, dietary protein supplementation did not result in a greater improvement in physical recovery outcomes during short-term inpatient rehabilitation. The intervention improved dietary protein intake, but further research (e.g., a full-scale randomized controlled trial with sufficient power) is required to determine the effects on physical function outcomes.

Preprint REVIEW | doi:10.20944/preprints202306.1728.v1

Nicotinamide Riboside, a Promising Vitamin B₃ Derivative for Healthy Aging and Longevity: Current Research and Perspectives

Andrei Biţă, Ion Romulus Scorei, Maria Viorica Ciocîlteu, Oana Elena Nicolaescu, Andreea Silvia Pîrvu, Ludovic Everard Bejenaru, Gabriela Rău, Cornelia Bejenaru, Antonia Radu, Johny Neamţu, George Dan Mogoşanu, Steven A. Benner

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: nicotinamide riboside; vitamin B3 derivative; efficacy; safety; healthy aging; longevity

Online: 25 June 2023 (10:43:10 CEST)

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NAD⁺ is known classically as a metabolite that participates in catabolic and anabolic pathways throughout the metabolism that is taught to students in introductory biochemistry courses. However, non-classical studies starting over a decade ago found that NAD⁺ is also involved in higher order functions, in part because of its involvement in the activation of SIRTs and the support of the mitochondrial unfolded protein response. Many studies since have suggested that NAD⁺ is involved in an extensive spectrum of human pathologies, including neurodegenerative disorders, cardiomyopathy, obesity, and diabetes, Further, healthy aging and longevity appear to be closely related to NAD⁺ and its related metabolites, including NAR and NMN. Together, these studies show that this system has value as a dietary supplement to improve general health overall, as well as mitigating specific disease conditions. Accordingly, many are now recommending the consumption of materials in this system as dietary supplements. Nicotinamide riboside (NAR) appears to have special value in this regard. It appears to be better tolerated than other molecules in this system, as well as better pharmacodynamics and greater potency. Unfortunately, NAR is a reactive molecule, often unstable during its manufacturing, transport, and storage. Indeed, HPLC analyses of many commercial samples of NAR shows that they contain substantial amounts of material that are not, in fact, NAR. In some of these commercial preparations, NAR is a minority component. Therefore, more stable derivatives of NAR that are easily converted upon consumption into NAR are therefore desired. Recently work related to prebiotic chemistry provided the borate derivative of NAR. NARB is considerably more stable than NAR itself. However, immediately upon consumption, the borate dissociates from NARB, and is lost in the body through dilution and binding to other species, notably carbohydrates such as fructose and glucose. The NAR left behind is expected to behave pharmacologically in ways identical to NAR itself. This review provides a comprehensive summary (through Q1 of 2023) of literature that makes the case for the consumption of NAR as a dietary supplement. It then summarizes the challenges of delivering quality NAR to consumers using standard synthesis, manufacture, shipping, and storage approaches. It concludes by outlining the advantages of NAR-borate in these processes.

Preprint REVIEW | doi:10.20944/preprints202302.0516.v1

The Confound of Hemodynamic Response Function Variability in Resting-State Functional MRI Studies

D Rangaprakash, Robert Barry, Gopikrishna Deshpande

Subject: Biology And Life Sciences, Biophysics Keywords: BOLD fMRI; HRF; resting state connectivity; aging; sex differences; confound

Online: 28 February 2023 (09:32:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0374.v1

Very Low and High Levels of Vitamin D are Associated with Shorter Leukocyte Telomere Length in 148,321 UK Biobank Participants

Chia-Ling Kuo, Ben Kirk, Meiruo Xiang, Luke C. Pilling, George A. Kuchel, Richard Kremer, Gustavo Duque

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Telomerase; leukocyte telomere length; vitamin D; aging; serum levels; geroscience

Online: 22 January 2023 (03:36:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0153.v2

Trends in Excess Winter Mortality (EWM) From 1900/01 to 2019/20—Evidence for a Complex System of Multiple Long-Term Trends

Rodney P. Jones, Andrey Ponomarenko

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: winter mortality; trends; season; estimated influenza mortality; pandemic influenza; aging

Online: 25 February 2022 (14:24:30 CET)

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Preprint REVIEW | doi:10.20944/preprints202111.0043.v1

Managing Skin Ageing as a Modifiable Disorder – The Clinical Application of Nourella® Dual Approach Comprising a Nano-encapsulated Retinoid, Retilex-A® and a Skin Proteoglycan Replacement Therapy, Vercilex®

Jan Wadstein, Israel Sánchez Alvarez, Erling Thom, Lidia Bernal López

Subject: Medicine And Pharmacology, Dermatology Keywords: Skin Aging; Rejuvenation; Skin Cream; Retinoid formulation; RetileX-A; Vercilex

Online: 2 November 2021 (10:55:27 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202108.0267.v1

From Oncological Paradigms to Non-Communicable Disease Pandemic. The Need of Recovery Human Biology Evolution

Elia Biganzoli, Romano Demicheli

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Cancer dormancy; Low-grade chronic inflammation; Healthy aging; Physical exercise

Online: 11 August 2021 (17:57:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0091.v1

Frailty as a Moderator of the Relationship Between Social Isolation and Health Outcomes in Community-Dwelling Older Adults

Fereshteh Mehrabi, François Béland

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Frailty; Social Isolation; Social Networks; Social Support; Social Participation; Aging

Online: 2 February 2021 (14:32:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0683.v1

Effectiveness of tDCS to Improve Recognition and Reduce False Memories in Older Adults

Juan C Melendez, Encarnación Satorres, Alfonso Pitarque, Iraida Delhom, Elena Real, Joaquin Escudero

Subject: Social Sciences, Psychology Keywords: transcranial direct current stimulation; true recognition; false recognition; aging; experiment.

Online: 28 December 2020 (11:15:38 CET)

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Preprint REVIEW | doi:10.20944/preprints202011.0019.v1

Semelparity and Reproductive Death in Caenorhabditis elegans

David Gems, Carina Kern, Joseph Nour, Marina Ezcurra

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: aging; biomass conversion; C. elegans; reproductive death; semelparity; senescent pathology

Online: 2 November 2020 (10:45:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0572.v1

Effects of Tenascin C on the Integrity of Extracellular Matrix and Skin Aging

Young Eun Choi, Min Ji Song, Mari Hara, Kyoko Imanaka-Yoshida, Dong Hun Lee, Jin Ho Chung, Seung-Taek Lee

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: aging; collagen; extracellular matrix; fibroblast; skin; tenascin C; TGF-β

Online: 28 October 2020 (08:49:54 CET)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202009.0168.v1

Prediction of Lung Function in Adolescence Using Epigenetic Aging: A Machine Learning Approach

Md. Adnan Arefeen, Sumaiya Tabassum Nimi, M. Sohel Rahman, S. Hasan Arshad, John W. Holloway, Faisal I. Rezwan

Subject: Computer Science And Mathematics, Computer Science Keywords: lung function; epigenetic aging; machine learning; feature selection; hyperparamter tuning

Online: 8 September 2020 (03:15:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0173.v1

Effect of Retrogression Re-aging Treatment on Corrosion Behavior of 7055 Al-Zn-MG Alloy

Fuqiang Guo, Shuwei Duan, Dongting Wu, Kenji Matsuda, Tao Wang, Yong Zou

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: Al-Zn-Mg alloy; Retrogression re-aging treatment; Corrosion; Electrochemistry

Online: 9 July 2020 (07:34:27 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202004.0158.v1

How studies on inflamm-aging may help to understand and combat COVID-19 pandemic.

Gianluca Storci

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Covid-19; SARS-CoV-2; Inflamm-aging; mtDNA; Telomere; Inflammation

Online: 9 April 2020 (14:43:41 CEST)

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More than 1,000,000 confirmed cases of COVID-19 have been registered worldwide since the beginning of the pandemic in Wuhan on December 2019. The high mortality rate of COVID-19 is associated with age, gender and the presence of comorbidities. Biochemical data have shown that COVID-19 patients develop a local and systemic hyper-inflammatory response associated with poor outcome. Therefore, the understanding of the biological mechanisms underlying SARS-CoV-2-induced inflammation is a compelling need. Following this reasoning, here we will focus on the importance of the progressive age-related development of a pro-inflammatory state (aka inflamm-aging) in the understanding of the unbalanced inflammatory response against SARS-CoV-2 in aged people. In particular, we underpin the role of mitochondrial DNA and genomic DNA telomeric sequences in local and systemic mechanisms of inflammation. Indeed, the leakage of mtDNA out of its natural compartment (i.e. the mitochondrion), into the cytoplasm and in the extracellular environment is a powerful trigger of innate immunity and inflammation, as part of an evolutionary-conserved signaling mechanism of cellular damage (e.g. viral infection). High levels of circulating mtDNA are increased in aged people and set up as inflammatory markers of poor prognosis in intensive care unit patients. In turn, telomeric DNA, which can be released into the cytoplasm and in the extracellular environment upon cell damage, has been proven to exert potent anti-inflammatory activity. Since that aged people (particularly those affected by co-morbidity) are equipped with shortened telomeres, we posit that, in aged people affected by COVID-19 the release of mtDNA, coupled with insufficient telomeric DNA favors the onset of a detrimental inflammatory response. In this regard, we highlight that the mechanism of action of some currently used drugs, as well as potential new ones may be better understood under the light of the above-depicted theoretical framework thus explaining how studies on inflamm-aging may help to understand and combat COVID-19 pandemic.

Preprint ARTICLE | doi:10.20944/preprints201904.0163.v1

Butyl Rubber-Based Composite: Thermal Degradation and Prediction of Service Life Time

Phuong Nguyen-Tri, Ennouri Triki, Tuan Anh Nguyen

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: polymer aging; swelling behavior; protective glove materials; elastomers; composites; rubber

Online: 15 April 2019 (11:29:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0120.v1

The Validity of a Mixed Reality-Based Automated Functional Mobility Assessment

Ruopeng Sun, Roberto G. Aldunate, Jacob J Sosnoff

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: mixed reality headset; mobility assessment; wearable sensor; fall risk; aging

Online: 10 April 2019 (08:33:16 CEST)

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Working Paper ARTICLE

Dietary Diversity and Nutritional Adequacy Among an Older Spanish Population with Metabolic Syndrome in the PREDIMED-Plus Study: A Cross-Sectional Analysis

Naomi Cano-Ibáñez, Alfredo Gea, Miguel A. Martínez-González, Jordi Salas-Salvadó, Dolores Corella, M. Dolors Zomeño, Dora Romaguera, Jesús Vioque, Fernando Aros, Julia Wärnberg, J. Alfredo Martínez, Lluis Serra-Majem, Ramón Estruch, Francisco Tinahones, José Lapetra, Xavier Pintó, Josep A. Tur, Antonio García-Ríos, Blanca Riquelme-Gallego, Miguel Delgado-Rodríguez, Pilar Matía, Lidia Daimiel, Vicente Martín, Josep Vidal, Clotilde Vázquez, Emilio Ros, Pilar Buil-Cosiales, Andrés Díaz-López, Rebeca Fernández-Carrión, Montserrat Fitó, Jadwiga Konieczna, Leyre Notario-Barandiaran, Ángel M. Alonso-Gómez, Eugenio Contreras-Fernández, Itziar Abete, Almudena Sánchez-Villegas, Rosa Casas, Araceli Muñoz-Garach, José Manuel Santos-Lozano, Laura Gallardo-Alfaro, Josep Basora, Olga Portoles, Miguel Ángel Muñoz, Manuel Moñino, Salvador Miralles Gisbert, Anai Moreno Rodríguez, Miguel Ruiz-Canela, Antoni Palau Galindo, Karla Alejandra Pérez-Vega, Aurora Bueno-Cavanillas

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Dietary diversity; nutrient adequacy; metabolic syndrome; aging; PREDIMED-Plus study

Online: 18 March 2019 (09:25:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints201901.0110.v1

Prediction Models to Control Aging Time in Red Wine

G Astray, JC Mejuto, V Martinez-Martinez, I Nevares, M Alamo-Sanza, Jesus Simal-Gandara

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Food authenticity; Toro appellation of origin; Prediction Models; Wine; Aging.

Online: 11 January 2019 (10:50:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints201812.0359.v1

Mechanical Behavior of Inconel 625 at Elevated Temperatures

Mauro M. de Oliveira, Antônio A. Couto, Gisele F. C. Almeida, Danieli A. P. Reis, Nelson B. de Lima, Renato Baldan

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: Inconel; high temperature; tensile test; creep; serrated; dynamic strain aging

Online: 31 December 2018 (09:41:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints201709.0149.v1

Long Term Aging Treatment Impact on Ultralow Iron Alloy 625 Intergranular Corrosion Property

Zhi-yuan Zhu, Yi Sui, An-lun Dai, Yuan-fei Cai, Ling-li Xu, Ze-xin Wang, Hong-mei Chen, Xing-ming Shao, Wei Liu

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: Alloy 625; aging sensitization treatment; intergranular corrosion; ASTM G28A methods

Online: 29 September 2017 (04:13:44 CEST)

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This paper investigates the evolution of microstructures and precipitations of an ultra-low iron alloy 625 subjected to long term aging treatment by scanning electron microscope (SEM) and X-ray diffraction(XRD). Use ASTM G28A acid Fe3(SO4)2 erosion to represent intergranular corrosion weightlessness and corrosive morphology. The result shows that alloy at 750C by aging treatment for 40h, precipitated γ'' phase in the grain boundary. In high density area of γ'' phase, occurs γ'' phase to δ phase degeneration transformation by aging treatment for 200h and the needle-like δ phase becomes more with time prolonged. And γ'' phase degenerated to δ phase completely until treated for 1000h. The sample which has aging treatment tends to have intergranular corrosion and mainly because alloy element spreading leads to dilution area and grain boundary precipitated phase, plus interlaced δ phase’s dissolving, which makes sample grain particle fall off and this results in apparent weightlessness. The weightlessness rate(WLR) is related with precipitated volume score. With aging sensitization time change, can be described by Johnson-Mehl-Avrami equation, i.e.:

W L R = 44.32 [1 - exp (- \frac{t}{10.99})] + 44.62 [1 - exp (- \frac{t}{327.8})] + 1.267 (m m / a)

Preprint ARTICLE | doi:10.20944/preprints201610.0003.v1

2nd life batteries on a gas turbine power plant to provide area regulation services.

Lluc Canals Casals, Beatriz Amante García

Subject: Engineering, Energy And Fuel Technology Keywords: Aging model; Lithium ion batteries; Second life applications, Area regulation

Online: 3 October 2016 (16:33:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.0110.v1

Cgrp Monoclonal Antibodies: Key Lessons from Real World Evidence

Bianca Orlando, Gabriella Egeo, Cinzia Aurilia, Giulia Fiorentini, Piero Barbanti

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: migraine; anti-CGRP mAbs; treatment; real-life; disability

Online: 2 September 2024 (13:38:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1278.v1

Research on the Anti-fatigue Effect and Mechanism of Arecoline in Sleep Deprived-Induced Mouse Fatigue

Danyang Wang, Yuan Sun, Jiameng Liu, Jing Sun, Bei Fan, Cong Lu, Fengzhong Wang

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Arecoline; Anti-fatigue; Glycolipid metabolism; Oxidative stress; Neurotransmitter

Online: 20 June 2024 (04:28:09 CEST)

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Objective: This research was aimed to estimate the anti-fatigue effects of arecoline and elucidate its underlying mechanisms using a murine model of central fatigue precipitated by sleep deprivation (SD). Methods: Seventy-two male C57BL/6 mice were randomly allocated into six groups: a control group, a SD-induced fatigue model group, a group receiving Rhodiola Rosea capsules (2.5 mg/kg), and arecoline groups administered low, medium, and high doses (10, 20, and 40 mg/kg, respectively). Following 28 days of continuous administrations, the effects of arecoline on the mouse fatigue-related behaviors was assessed by the behavioral tests, including grip strength, rotarod performance, and weight-bearing swimming endurance. Enzyme-linked immunosorbent assays (ELISAs) were utilized to measure the levels of the relevant biochemical markers. Western blotting was employed to quantify the expression of nuclear factor erythroid 2-related factor (Nrf2), Kelch-like ECH-associated protein 1 (Keap1), heme oxygenase 1 (HO-1), sequestosome-1 (p62), and NADPH quinone oxidoreductase 1 (NQO1) in the gastrocnemius muscle. Results: Arecoline administration notably enhanced grip strength, delayed the onset of fatigue as evidenced by extended latencies in rotarod tests, and increased the duration of weight-bearing swimming in mice. In the elevated plus maze, arecoline significantly reduced both the number of entries and the total distance traveled in the open arms. Arecoline markedly decreased serum levels of creatine kinase, blood urea nitrogen, lactate dehydrogenase, triglycerides, and cholesterol, while elevated total testosterone, lactate dehydrogenase, and immunoglobulin G levels. Furthermore, it significantly increased superoxide dismutase(SOD), catalase(CAT), and glutathione peroxidase activity in the gastrocnemius muscle, reduced malondialdehyde levels, augmented hippocampal SOD and CAT activity, and elevated glycogen stores in both liver and muscle tissues. Neurotransmitter levels were significantly increased, cytokine levels were markedly reduced, and the expression of Nrf2, Keap1, NQO1, p62, and HO-1 in brain tissue was significantly upregulated. Conclusion: The current study for the first time demonstrated that arecoline has significant anti-fatigue activity, and its mechanism of action is related to elevate the levels of glucose and lipid metabolism, relieve oxidative stress damage, inhibit neuroinflammatory response, regulate neurotransmitter levels and Keap1/Nrf2/HO-1 signaling pathway. The current study provides a new insight into the potential of arecoline in prevention and improvement of fatigue.

Preprint REVIEW | doi:10.20944/preprints202403.1292.v1

A Review of Recent Curcumin Analogues and Their Antioxidant, Anti-inflammatory and Anticancer Activities

Kirandeep Kaur, Ahmad K. Al-Khazaleh, Deep Jyoti Bhuyan, Feng Li, Chun Guang Li

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: curcumin; modification; anti-inflammatory; antioxidant; anticancer, curcumin analogues

Online: 21 March 2024 (14:07:15 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0759.v1

Clinical Significance and Remaining Issues of Anti‐ HBc Antibody and HBV Core‐Related Antigen

Yoshihiko Yano, Itsuko Sato, Takamitsu Imanishi, Ryutaro Yoshida, Takanori Matsuura, Yoshihide Ueda, Yuzo Kodama

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: anti-HBc antibody; HBV core-related antigen; HBV

Online: 14 February 2024 (09:11:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1149.v1

Anti-Icing Epoxy-Modified Silica Nano-Composite Coating on Conductors Used in Overhead Power Lines

Akbar Eshaghi, Hossein Salehi, Faezeh Saeedi, Abolfazl Bayati

Subject: Engineering, Other Keywords: SiO2; hydrophobic; Anti-icing; Self-cleaning; protective coatings

Online: 18 October 2023 (08:22:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0342.v1

In Vitro Evaluation of Antioxidant and Anti-Glycation Activity of Crocin from Different Saffron Extracts

Simone Ronsisvalle, Annamaria Panico, Debora Santonocito, Edy Angela Siciliano, Federica Sipala, Lucia Montenegro, Carmelo Puglia

Subject: Biology And Life Sciences, Virology Keywords: crocin; saffron extracts; antioxidants; carotenoids; anti-glycation activity

Online: 5 September 2023 (17:01:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0077.v1

Evaluation of Complex Carbohydrates Showing Broad-Spectrum Antiviral Activity against SARS-CoV-2, Influenza-a (H1N1) and Human Respiratory Syncytial Virus (hRSV) Strain A2 in ‘In Vitro’ Setting

David Platt, Alben Sigamani, Nehal Shah

Subject: Biology And Life Sciences, Virology Keywords: Infection; Influenza; anti-viral; ProLectin-M; ProLectin-I

Online: 4 September 2023 (03:50:33 CEST)

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ntroduction: Respiratory tract Infections are the greatest cause of death worldwide. Since its outbreak in 2019, the coronavirus pandemic (COVID-19) has been a challenge to humans in terms of treatment and prevention of this respiratory viral infection. The re-emergence of respiratory viral infections like influenza, pose a serious hazard to global public health because they occur seasonally. Creating broad-spectrum antiviral compounds for rapid action in the case of an outbreak crisis, as well as bioweapon defences, is critical. Human galectin-3 is found in high concentrations in activated T lymphocytes, epithelial and endothelial cells, and fibroblasts. ProLectin -I and ProLectin -M are both galectin antagonists. Blocking viral entry with a complex polysaccharide component "ProLectin-M" has downstream effects on viral reproduction enabling it to be used as a therapeutic tool and a safe alternative to conventional anti-viral medicines. Methods: In total, 3 cell based assays have been conducted to evaluate antiviral efficacy of ProLectin–I and ProLectin-M against SARS-CoV-2 virus, Influenza-A (H1N1), and human respiratory syncytial virus (hRSV) strain A2. ProLectin-M and ProLectin-I were evaluated for their anti-viral potency using SARS-CoV2 virus strain by viral RNA Extraction and qRT-PCR assays. The plaque assays were carried out to determine the antiviral activity of the test products (ProLectin-I and ProLectin-M) against ‘Influenza-A (H1N1)-A/PR/8/34 (TC adapted)’ and ‘Human respiratory syncytial virus (hRSV) strain A2’ in a cell based in vitro setting. As eference standard, "Oseltamivir Phosphate" and "Remdesivir" were used to determine antiviral activity of test products against H1N1 and hRSV strains respectively.Results: The IC_{50 of}ProLectin-M and ProLectin-I against SARS-CoV-2 virus was found to be 6248 ng/ml (6.2µg/ml) and 4207 ng/ml (4.2μg/ml) respectively. The CC₅₀ value was similar in both the test products i.e. >100 µg/ml. Against Influenza A (H1N1) strain, ProLectin-M exhibited 95 % reduction in the viral load at the test concentration of 21.8 µg/mL with an IC₅₀ value of 5.4 µg/mL whereas, ProLectin-I did not show any cytotoxicity till 250 µg/mL concentration. Against 'human respiratory syncytial virus (hRSV) strain A2, ProLectin-M exhibited 65 % reduction in the viral load at the test concentration of 43.75 µg/mL with an IC₅₀value of 27.41 µg/mL whereas, ProLectin- I did not show any cytotoxicity till 250 µg/mL concentration. Conclusion: Both ProLectin-I and ProLectin-M have been reported to exhibit broad-spectrum antiviral activity in ‘in-vitro’ setting. ProLectin-M reducing influenza-A virus by 95% and hRSC strain A2 by 65%. To better understand broad spectrum antiviral activity of ProLectin-I and ProLectin-M, further pre-clinical research is warranted.

Preprint ARTICLE | doi:10.20944/preprints202308.1856.v1

In Vitro and In Silico Evaluation of the Anti-leishmanial Activity of Novel Synthetic Chalcones

Fernando Ferreira Leite, Luis Cezar Rodrigues, Bruno Hanrry Melo De Oliveira, Gabrielly Diniz Duarte, Maria Denise Leite Ferreira, Natália Ferreira De Sousa, Shayenne Eduarda Ramos Vanderley, Leonardo Lima Cardoso, Tatjana Souza Lima Keesen, Rodrigo Santos Aquino De Araújo, Luciana Scotti, Marcus Tullius Scotti, Francisco Jaime Bezerra Mendonça-Junior

Subject: Biology And Life Sciences, Parasitology Keywords: chalcones; anti-leishmanial activity; molecular docking; molecular dynamic

Online: 28 August 2023 (10:27:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.1647.v1

Cytokine Profile in Lung Cancer Patients: Anti-tumor and Oncogenic Cytokines

Essogmo Freddy Elad, Zhilenkova Angelina V., Abah Moses Owoicho, Ngaha Tchawe Yvan Sinclair, Alexander S. Rusanov, Alexander Boroda, Yuliya N. Pirogova, Zaiana D. Sangadzhieva, Varvara D. Sanikovich, Nikolay N. Bagmet, Marina I. Sekacheva

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Lung cancer; Cytokines; Therapy; Immune system; Anti-tumor

Online: 23 August 2023 (09:55:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0952.v1

Cochayuyo (Durvillaea incurvata) Extracts: Their Impact on Starch Breakdown and Antioxidant Activity in Pasta During In Vitro Digestion.

Luz Verónica Pacheco, Javier Parada, José R. Pérez-Correa, María Salomé Mariotti-Celis, Mario Simirgiotis

Subject: Biology And Life Sciences, Food Science And Technology Keywords: phlorotannin; starch digestion; edible seaweed; anti-diabetic effect

Online: 11 August 2023 (13:20:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0214.v1

An in-Depth Study on the Anti-Oxidant and Anti-Apoptotic Potentials of Quercetin in Human Colon Cancer Cell Lines

Meenu Bhatiya, Samatha M Jain, Alakesh Das, Surajit Pathak, Sheikh F Ahmad, Asim K Duttaroy, Antara Banerjee

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: quercetin; antioxidant; apoptotic; anti-inflammatory activity; colon cancer

Online: 3 August 2023 (02:42:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1845.v1

Is Slovakia Almost a Hepatitis D Free Country?

Pavol Kristian, Ivana Hockicková, Elena Hatalová, Daniela Žilinčanová, Marek Rác, Veronika Bednárová, Patrícia Denisa Lenártová, Sylvia Dražilová, Ľubomír Skladaný, Ivan Schréter, Peter Jarčuška, Monika Halánová

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: hepatitis D; prevalence; anti-HDV antibody; HDV RNA

Online: 27 July 2023 (10:26:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1457.v1

In Vitro and In Silico Analysis of Alpha-Amylase Inhibitory Activity of Ethanolic Extract of Adhatoda vasica Leaves

Chandrajeet Kumar Yadav, Sandhya KC, Shankar Thapa, Kamal Kandel, Laxmi Shrestha, Anjan Palikhey, Ashish Lamsal

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Anti-diabetic; Alpha amylase; Adhatoda vasica; Molecular docking

Online: 21 July 2023 (10:09:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0895.v1

Cognitive Impairment in MRI-Negative Epilepsy: Relationship between Neurophysiological and Neuropsychological Measures

Vasileios Papaliagkas, Chrysanthi Lokantidou-Argyraki, Panayiotis Patrikelis, Georgia Zafeiridou, Martha Spilioti, Theodora Afrantou, Mary-Helen Kosmidis, Marianthi Arnaoutoglou, Vasileios K Kimiskidis

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Event Related Potentials; Epilepsy; P300; Anti-Seizure Medication

Online: 13 July 2023 (07:40:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1156.v1

Measles Immunity Status of Greek Population After the Outbreak in 2017-2018: Results From a Seroprevalence National Survey

Asimina Nasika, Zacharoula Bogogiannidou, Varvara A. Mouchtouri, Katerina Dadouli, Maria A. Kyritsi, Alexandros Vontas, Ioanna Voulgaridi, Zafeiris Tsinaris, Konstantina Kola, Alexia Matziri, Athanasios G. Lianos, Ourania Founta, Ourania Kontogianni, Fani Kalala, Efthimia Petinaki, Matthaios Speletas, Christos Hadjichristodoulou

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: measles; seroprevalence; immunity; anti-measles IgG antibodies; Greece

Online: 15 June 2023 (14:40:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1031.v1

The ANTI-Vea-UGR Platform: A Free Online Resource To Measure Attentional Networks (Alertness, Orienting, and Executive Control) Functioning and Executive/Arousal Vigilance

Tao Coll-Martín, Rafael Román-Caballero, María del Rocío Martínez-Caballero, Paulina del Carmen Martín-Sánchez, Laura Trujillo, Luis Cásedas, M. Concepción Castellanos, Klara Hemmerich, Greta Manini, María Julieta Aguirre, Fabiano Botta, Andrea Marotta, Elisa Martín-Arévalo, Luna Fernando G. Gabriel, Juan Lupiáñez

Subject: Social Sciences, Psychology Keywords: vigilance; attention; online assessment; ANTI-Vea; attentional networks

Online: 14 June 2023 (09:35:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0592.v1

Anti-inflammatory and Antioxidant Potential of Pteropodine in Rodents

Rogelio Paniagua-Pérez, Laura Sánchez-Chapul, Eduardo Madrigal-Bujaidar, Isela Álvarez-González, Eduardo Madrigal-Santillán, Lidia Cruz-Hernández, Carlos Matínez-Canseco, Celia Reyes-Legorreta, Lidia Ruíz-Rosano, Cecilia Hernández-Flores, Rene Valdez-Mijares, Alejandra Quintana-Armenta

Subject: Biology And Life Sciences, Toxicology Keywords: anti-inflammatory assays; murine model; rodent-induced edema

Online: 8 June 2023 (07:34:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1690.v1

Association of Positive Hepatitis B Serology Markers With Risk and Behavior Factors in Kazakhstan Blood Donors: A Cross Sectional Study

Tatyana Savchuk, Yelena Grinvald, Mohamed Ali, Ramune Sepetiene, Saniya Saussakova, Kuralay Zhagazieva, Dulat Imashpayev, Saniya Abdrakhmanova

Subject: Biology And Life Sciences, Virology Keywords: hepatitis B; anti HBcore; risk factors; blood donors

Online: 24 May 2023 (04:37:56 CEST)

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Background and Aim. Recently made analysis for anti-HBcor prevalence within Kazakhstan blood donors population concluded 17.2% rate. Considering these data are among the highest of infectivity results worldwide, an objective of this study was to define an association of positive Hepatitis B serology markers with risk and behavior factors. Methods. The blood donors’ samples were tested for anti-HBcore total (IgG/IgM) and anti-HBs, by CLIA on the Architect i2000SR platform (Abbott). Surrogate alanine transferase (ALT) markers for all blood donors were tested by kinetic method on the Biosystems A25 analyzer. A questionnaire was developed for socio-demographic characteristics, donors’ nutrition habits, cholesterol levels and history of smoking, alcohol consumption. Informed consent was obtained from all study participants. Statistics was calculated using the R software program (version 4.1.1, USA, 2021). Results. A group of 5709 blood donors participated in the study. Participants with positive anti-HBcore scores were on average older (41.8 vs 34.4 years, p<0.001), Kazakh (88.7% vs 83.0%, p<0.001), married (74.0% vs 55.6%, p<0.001), had a secondary education (70.1% vs. 59.4%, p=0.03), smoked (27.9% vs. 24.3%, p=0.05), had a longer smoking history (13.6±9.5 years vs. 9.8±8.5 years, p<0.001), and various hypercholestesterolaemia (6.2% vs 3.9%, p=0.02). Predominantly their main meal was dinner (17.0% vs 14.2%, p=0.03). Analysis for associations of socio-demographics characteristics, risk factors, nutrition with anti-HBs, showed that those who have secondary education level (70.1%) were more likely to be anti-HBs-positive (p=0.03). No other significant correlations for anti-HBs were observed. Conclusions. The risk factors and behavior analysis highlighted the blood donors’ overall health status. Positive Hepatitis B markers associated with statistically significant characteristics from socio-demography, nutrition habits or risk factors could support further pathogenesis studies looking for HBV treatment guides fulfilling the existing gaps.

Preprint REVIEW | doi:10.20944/preprints202305.1106.v1

Trends in Photothermal Nanostructures for Antimicrobial Applications

Violeta Dediu, Jana Ghitman, Gratiela Gradisteanu-Pircalabioru, Kiat Hwa Chan, Florina Silvia Iliescu, Ciprian Iliescu

Subject: Biology And Life Sciences, Life Sciences Keywords: photothermal-antimicrobials; antibacterial mechanisms; anti-biofilm; wound healing

Online: 16 May 2023 (05:40:58 CEST)

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Rapid developing antimicrobial resistance due to broad antibiotic utilisation in healthcare and food industries and the non-availability of novel antibiotics represents one of the most critical public health issues worldwide. The current advances in nanotechnology allow new materials to address drug-resistant bacterial infections in specific, focused and biologically safe ways. The unique physicochemical properties, biocompatibility, and wide range of adaptability of nanomaterials that exhibit photothermal capability can be employed to develop the next generation of photothermally induced controllable hyperthermia as antibacterial nanoplatforms. Here, we review the current state-of-the-art in different functional classes of photothermal antibacterial nanomaterials and the strategies to optimise antimicrobial efficiency. The recent achievements and trends in developing photothermally active nanostructures, including plasmonic metals, semiconductor, carbon-based, and organic photothermal polymers, and antibacterial mechanisms of action, including anti-multidrug resistant bacteria and biofilms removal, will be discussed. Insights into mechanisms of the photothermal effect and various factors influencing photothermal antimicrobial performance, emphasising the structure–performance relationship, are discussed. We will examine the photothermal agents’ functionalisation for specific bacteria, effects of near-infrared light irradiation spectrum, or active photothermal materials for multimodal synergistic-based therapies to minimise side effects and maintain low cost. Most relevant applications are presented, such as anti-biofilm formation, biofilm penetration or ablation, and nanomaterial-based infected wound therapy. Practical antibacterial applications employing the photothermal antimicrobial agents, alone or in synergistic combination with other nanomaterials, are considered. Existing challenges and limitations in photothermal antimicrobial therapy and future perspectives are presented from the structure, function, safety, and clinical potential points of view.

Preprint ARTICLE | doi:10.20944/preprints202305.0263.v2

Digital Transformation Unleashed: How to Detect and Eliminate Agile Anti-Patterns in Organizational Culture

Dinko Canales, Roberto Moraga

Subject: Business, Economics And Management, Business And Management Keywords: Agile; agility; scrum; culture; digital transformation; anti-patterns

Online: 8 May 2023 (15:40:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0008.v1

Understanding Anti-Influenza Antiviral Drugs

Sidney Ley

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: influenza; antivirals; anti-influenza; influenza drugs; the flu

Online: 1 August 2022 (05:41:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0258.v1

Melatonin Decreases Acute Inflammatory Response to Neural Probe Insertion

Daniela D. Krahe, Kevin M. Woeppel, Qianru Yang, Neetu Kushwah, Xinyan Tracy Cui

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Melatonin; glial scar; insertion trauma; anti-inflammatory; antioxidant

Online: 18 July 2022 (10:08:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0625.v1

The Dual Role of Toll-like Receptor10

Motahareh Dargahi, Niloufar Taheri, Zahra Mirsanei, Arezoo Rasti, Reza Jafari

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Toll-Like Receptor; Innate Immunity; Inflammation; Anti-inflammation

Online: 26 May 2021 (08:17:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0204.v1

Chitosan Elicitation Impacts Flavonolignan Biosynthesis in Silybum marianum (L.) Gaertn Cell Suspension and Enhances Antioxidant and Anti-inflammatory Activities of Cell Extracts

Muzamil Shah, Hasnain Jan, Samantha Drouet, Duangjai Tungmunnithum, Jafir Hussain Shirazi, Hano Christophe, Bilal Haider Abbasi

Subject: Biology And Life Sciences, Plant Sciences Keywords: Antioxidant; Anti-inflammatory; Chitosan; Flavonoids; Phenolics; Silybum marianum

Online: 11 January 2021 (15:59:31 CET)

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Silybum marianum (L.) Gaertn is a rich source of antioxidants and anti-inflammatory flavonolignans with great potential for use in pharmaceutical and cosmetic products. Its biotechnological production using in vitro culture system has been proposed. Chitosan is a well-known elicitor that strongly affects both secondary metabolites and biomass production by plants. The effect of chitosan on S. marianum cell suspension is not known yet. In the present study, suspension cultures of S marianum were exploited for their in vitro potency to produce bioactive flavonolignans in the presence of chitosan. Established cell suspension culture was maintained on the same hormonal media supplemented with 0.5 mg/L BAP (6-benzylaminopurine) and 1.0 mg/L NAA (α-naphthalene acetic acid) under photoperiod 16/8 h (light/dark) and exposed to various treatments of chitosan (ranging from 0.5 to 50.0 mg/L). The highest biomass production was observed for cell suspension treated with 5.0 mg/L chitosan, resulting in 123.3 g/L fresh weight (FW) and 17.7 g/L dry weight (DW) productions. Chitosan treatment resulted in an overall increase in the accumulation of flavonoids, phenolic compounds and silymarin. High accumulation levels of silybin B, silydianin and silybin A were recorded by HPLC analysis. The corresponding extracts displayed interesting antioxidant and anti-inflammatory capacities. In particular, high ABTS antioxidant activity (741.5 μM Trolox C equivalent antioxidant capacity) was recorded in extracts obtained in presence of 0.5 mg/L of chitosan. On the opposite, highest inhibitions of cyclooxygenase 2 (COX-2, 30.5 %), secretory phospholipase A2 (sPLA2, 33.9 %) and 15-lipoxygenase (15-LOX-2, 31.6 %) enzymes involved in inflammation process were measured in extracts obtained in presence of 5.0 mg/L of chitosan. Taken together, these results highlight the high potential of the chitosan elicitation of the S. marianum cell suspension for enhanced production of antioxidant and anti-inflammatory silymarin-rich extracts.

Preprint ARTICLE | doi:10.20944/preprints202012.0340.v1

Socio-Medical Studies of Individuals Self-Treating with Helminths Suggest That Most Clinical Trials Assessing Helminth Therapy May Be Designed to Fail

Aarushi Venkatakrishnan, Joshua Hames, Kateřina Jirků-Pomajbíková, William Parker

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: helminth; helminthic therapy; biological therapy; inflammation; anti-inflammatory

Online: 14 December 2020 (13:40:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0446.v1

Compounds with Anti-Onchocercal Activity from Voacanga africana Stapf (Apocynaceae): Identification and Molecular Modeling

Smith Babiaka, Conrad Simoben, Kennedy Abuga, James Mbah, Rajshekhar Karpoormath, Dennis Ongarora, Hannington Mugo, Elvis Monya, Fidelis Cho-Ngwa, Wolfgang Sippl, Joel Loveridge, Fidele Ntie-Kang

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Alkaloids; Anti-Onchocercal; Bisindoles; Docking; Homology Modeling; Monoindoles.

Online: 17 November 2020 (11:13:54 CET)

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Working Paper REVIEW

Tissue Fibrosis, Aging and the Potential Use of Cannabinoids as Anti-Fibrotic Agents

Nazar Pryimak, Mariia Zaiachuk, Olga Kovalchuk, Igor Kovalchuk

Subject: Biology And Life Sciences, Plant Sciences Keywords: fibrosis; medicinal plants; Cannabis sativa; cannabinoids; anti-fibrotic

Online: 22 October 2020 (12:41:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0443.v1

Establishment of a Cell Suspension Culture of Ageratina Pichinchensis for the Improved Production of Anti-inflammatory Compounds

Mariana Sánchez-Ramos, Laura Alvarez, Antonio Romero-Estrada, Antonio Bernabé-Antonio, Silvia Marquina-Bahena, Francisco Cruz-Sosa

Subject: Biology And Life Sciences, Plant Sciences Keywords: cell suspension culture; anti-inflammatory activity; phytochemical analysis

Online: 20 August 2020 (07:44:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0178.v1

Viability of 4 Wild Strains L. paraplantarum, L. plantarum, W. paramesenteroides, and E. faecalis in Fermented Probiotic Grape Marmalade during Storage at both 5°C and 25°C

Lesly Samedi, Albert Linton Charles

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: anti-oxidative properties; DPPH; grape marmalade; lactobacillus; probiotics

Online: 16 April 2019 (10:27:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints201903.0116.v1

Red Beetroot and Betalains as Cancer Chemopreventative Agents

John F. Lechner, Gary D. Stoner

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: beetroot; betanins; cancer chemoprevention; anti-oxidant; inflammation; apoptosis

Online: 11 March 2019 (08:00:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0629.v1

Explore the Potential Mechanism of Bufadienolides-Like Chemicals on Breast Cancer through Bioinformatics Analysis

Yingbo Zhang, Xiaomin Tang, Yuxin Pang, Luqi Huang, Dan Wang, Chao Yuan, Xuan Hu

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: bufadienolides-like chemicals; molecular mechanism; anti-cancer; bioinformatics

Online: 30 November 2018 (10:14:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0170.v1

Competing-Risk Analysis of Death and ESKD by Hyperkalemia Status in Non-Dialysis CKD Patients Receiving Stable Nephrology Care

Michele Provenzano, Roberto Minutolo, Paolo Chiodini, Vincenzo Bellizzi, Felice Nappi, Domenico Russo, Silvio Borrelli, Carlo Garofalo, Carmela Iodice, Toni De Stefano, Giuseppe Conte, Hiddo Heerspink, Luca De Nicola

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: CKD, ESKD, Death, anti-RAS, hyperkalemia, competing risk

Online: 7 November 2018 (14:48:30 CET)

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Preprint REVIEW | doi:10.20944/preprints201806.0168.v1

New Therapies of Neovascular AMD – Beyond Anti VEGFs

Praveen Yerramothu

Subject: Medicine And Pharmacology, Ophthalmology Keywords: neovascular AMD; new therapies; anti-VEGFs; AMD signalling

Online: 12 June 2018 (06:26:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints201802.0084.v1

Dual Antiplatelet Therapy (DAPT) in Coronary Artery Disease: A Daunting Dilemma

Suryateja Chaturvedula, Daniel J. Diver, Aseem Vashist

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: dual anti platelet therapy; acute coronary syndrome; stents

Online: 12 February 2018 (05:13:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0221.v1

Dimacrolide Sesquiterpene Pyridine Alkaloids from the Stems of Tripterygium regelii

Dongsheng Fan, Guo-Yuan Zhu, Ting Li, Zhi-Hong Jiang, Li-Ping Bai

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: Tripterygium regelii; dimacrolide sesquiterpene pyridine alkaloids; anti-inflammation

Online: 29 August 2016 (10:46:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0489.v1

XENOFOOD-An Autoclaved Feed Supplement Containing Autoclavable Antimicrobial Peptides-Exerts Anticoccidial GI Activity, and Causes Bursa Enlargement, but Has No Detectable Harmful Effects in Broiler Cockerels despite In Vitro Cytotoxic Ingredients

ANDRÁS FODOR, Tibor Vellai, Claudia Hess, Petra Ganes, László Makrai, Károly Dublecz, László Pál, Andor Molnár, László Fodor, Sándor Józsa, Csaba Pintér, Michael Gardner Klein, Eustachio Tarasco, Michael Hess

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: multidrug resistance; MDR; EPB (Xenorhabdus; (X. budapestensis; X. szentirmaii; X. innexii); and Photorhabdus) species); CFCM (cell-free conditioned media); NR-AMP (non-ribosomal-templated antimicrobial peptides); anti-microbial; (anti-bacterial; - anti-coccidial; -anti-protist; - activity; cytotoxicity; in vitro; in situ (local) bioavailablity; XENOFOOD; allometry

Online: 27 January 2023 (06:21:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0053.v1

On the Origin of Aging by Means of Natural Selection

Richard Francis Walker

Subject: Biology And Life Sciences, Aging Keywords: aging vs survival; DNA damage; double-stranded breaks; Gompertz-Makeham Law; developmental regulatory redundancy; tradeoffs vs emergent properties; fecundity; reproductive fitness; redundancy reliabiiity; programmed aging

Online: 2 October 2023 (08:08:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202402.1344.v1

Autoimmune Thyroiditis and Vitamin D

Teodoro Durá-Travé, Fidel Gallinas Victoriano

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Anti-thyroglobulin antibodies; Anti-thyroid peroxidase; Autoimmunity; Autoimmune thyroiditis; Hashimoto thyroiditis; Immune cells; Vitamin D; Vitamin D deficiency; Vitamin D supplementation

Online: 23 February 2024 (10:08:09 CET)

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Preprint REVIEW | doi:10.20944/preprints202408.0053.v1

Medicines in Development for Venous Thromboembolism

Masoud Salavati, Arman Arabshomali, Sasan Nouranian, Zia Shariat-Madar

Subject: Medicine And Pharmacology, Hematology Keywords: thrombotic disorders; targeted-antithrombotic approaches; nanothrombolysis; clot-penetrating drug; aging; fibrinolysis

Online: 2 August 2024 (03:57:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1286.v1

Relationship of Healthy Vascular Aging with the Mediterranean Diet and Other Lifestyles in the Spanish Population, EVA Study

Leticia Gómez-Sánchez, David Gonzalez-Falcon, Rocio Llamas-Ramos, María Cortes-Rodriguez, Emiliano Rodríguez-Sánchez, Luis García-Ortiz, Ines Llamas-Ramos, Marta Gómez-Sánchez, Manuel A. Gómez-Marcos

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Mediterranean diet; tobacco; alcohol; physical activity; sedentary time; healthy vascular aging

Online: 16 July 2024 (07:37:44 CEST)

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The aim of this study was to analyze the relationship between healthy vascular aging (HVA) and the Mediterranean diet alongside other lifestyles in a Spanish population aged 35 to 75 years without previous cardiovascular diseases. Methods: Cross-sectional descriptive study with 501 individuals aged 35 to 75 years recruited from five health centers by random sampling stratified by age and sex (55.90±14.24 years, 49.70% men). HVA was determined in two steps. Step 1: Subjects with vascular damage to the carotid arteries or peripheral arterial disease were classified as non-HVA. Step 2: The study population was classified by age and sex using the percentiles of the vascular aging index (VAI), with VAI ≤p25 considered HVA and >p25 considered non-HVA. The VAI was estimated using the following formula (VAI = (log (1.09) × 10 cIMT + log (1.14) cfPWV) × 39.1 + 4.76. Carotid-femoral pulse wave velocity (cfPWV) was measured with the SphygmoCor^® device and carotid intima-media thickness using Sonosite Micromax^® ultrasound. Mediterranean diet (MD) adherence, alcohol and tobacco use were recorded through validated questionnaires. Physical activity was assessed with the ActiGraph-GT3X^® accelerometer. Results: The mean VAI value was 61.23±12.86; (Men 63.47±13.75 and women 59.04±11.54; p<0.001). HVA was found in 18.9% (men 19.9% and women 17.8%). In the multiple regression analysis after adjusting for possible confounding factors, the mean VAI value showed a positive association with alcohol use (β=0.020) and sedentary hours per week (β=0.109), and a negative association with hours of activity per week (β=-0.102) and with the number of healthy lifestyles (β=-0.640). In the logistic regression analysis after adjusting for possible confounding factors, and compared to those classified as non-HVA, subjects classified as HVA were more likely to show adherence to MD (OR = 0.571), perform more than 26 hours per week of physical activity (OR = 1.735), spend less than 142 hours per week being sedentary (OR = 1.696), and have more than two healthy lifestyles (OR = 1.877). Conclusion: The results of this study suggest that the more time spent doing physical activity and the less time spent sitting, the lower the vascular aging index and the greater likelihood of being classified in the group of subjects showing HVA.

Preprint ARTICLE | doi:10.20944/preprints202405.0034.v1

Intergenerational Synchrony and Its Effect on Bonding and Group Closeness among Young and Older Adults

Assaf Suberry, Ehud Bodner

Subject: Social Sciences, Other Keywords: Dance; Intergenerational interventions; Personality; Social bonding; Synchrony; Aging; Group processes ;

Online: 2 May 2024 (07:57:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1802.v1

Aging Renewal Point Processes and Exchangeability of Event Times

Fabio Vanni, David Lambert

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: renewal processes; exchangeability; statistical aging; survival analysis; high frequency exchange rates

Online: 29 March 2024 (07:41:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1038.v1

Protocol for the Nutrition for Brain and Body Health Study: A Randomized Feasibility Trial

Rachel Silver, Suzannah Gerber, Sai Krupa Das, Savana Greene, Maria Carlota dao, John Sunwoo, Lisa Ceglia, Sadie Dix, Kathryn Barger, Maria Angeline Franceschini, Ronald Cohen, Susan Roberts

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: cognitive decline, aging, obesity, nutrition, clinical trial, protocol, Alzheimer's, neurodegenerative, food

Online: 18 March 2024 (12:12:31 CET)

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Older adults with obesity have an increased risk for cognitive decline and subsequent Alzheimer’s disease. Previous research has focused on the impact of individual nutrients and overall dietary patterns to improve cognitive function. The Brain and Body Health (BB-Health) study aims to demonstrate the feasibility of a multicomponent nutritional supplement (MCNS) and weight loss (WL) intervention for individuals with overweight and obesity who are not consuming a healthy diet. BB-Health is a parallel-group randomized placebo-controlled 2x2 factorial pilot trial comparing the MCNS, WL, and MCNS+WL with a Control group. Eligible participants are 55 to 85 years of age with a body mass index 27.0 to 39.9 kg/m2. Major exclusion criteria include type 2 diabetes, moderate or severe cognitive impairment, and self-reported healthy dietary pattern. The BB-Health feasibility trial is registered as NCT05542199 at clinicaltrials.gov. The BB-Health objectives are to report: 1) recruitment and enrollment, including pace and descriptive statistics of the study sample; 2) adherence to the administered interventions; 3) successful data collection and performance of outcome assessments, including evaluation of change in key outcomes over time that are powered for this pilot study; and 4) summary statistics on outcomes for use in planning a subsequent, larger trial. The outcomes of interest are age-sensitive cognitive assessments, cerebral hemodynamics, and related health parameters. All measurements are collected at baseline, 3-, 6-, and 12-month visits. If the BB-Health protocol demonstrates feasibility, the novel MCNS with and without a parallel WL intervention has potential to be administered in a confirmatory randomized trial to evaluate ability to prevent age-related cognitive decline and improve brain health. The BB-Health Feasibility Study could significantly contribute to our understanding of the influence of diet and weight management on cognitive health

Preprint ARTICLE | doi:10.20944/preprints202401.0211.v1

Tobacco Smoking as an EDC in Aging

Ho-Sun Lee, Hyun-Kyung Na, Seong-Sil Chang, Soo-Young Kim, Chang Seong Kim, Yoonjeong Song, Mihi Yang

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: tobacco smoking; biological monitoring; adolescent; genetic polymorphism; addiction; mtDNA alteration; aging

Online: 4 January 2024 (03:43:27 CET)

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Preprint REVIEW | doi:10.20944/preprints202309.1738.v1

Zebrafish as an Emerging Model for Sarcopenia: Considerations, Current Insights, and Future Directions

Santiago Callegari, Foad Mirzaei, Lila Agbaria, Sanobar Shariff, Burhan Kantawala, Desmond Moronge, Brian M. O. Ogendi

Subject: Biology And Life Sciences, Aging Keywords: Sarcopenia; Zebrafish; Age-related muscle deficits; Aging; Biomarkers; Electrical Impedance Myography

Online: 26 September 2023 (13:38:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.0213.v1

Nitric Oxide as a Determinant of Human Longevity and Health Span

Burkhard Poeggeler, Kumar Sandeep Singh, Kumar Sambamurti, Miguel A. Pappolla

Subject: Biology And Life Sciences, Aging Keywords: aging; amino acids; antioxidant; arginine; nitric oxide; oxidative stress; protein; peptide

Online: 6 September 2023 (14:47:08 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.0090.v1

Nitric Oxide as a Determinant of Human Longevity and Health Span

Burkhard Poeggeler, Sandeep Kumar Singh, Kumar Sambamurti, Miguel A. Pappolla

Subject: Biology And Life Sciences, Aging Keywords: aging; amino acids; antioxidant; arginine; nitric oxide; oxidative stress; protein; peptide

Online: 1 September 2023 (16:25:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1184.v1

Diagnosing Alzheimer's Disease Levels Using Machine Learning and MRI: A Novel Approach

Reza Bahadori, Ali Akbar Kiaei, Hourieh Malek Zadeh, Mahnaz Boush, Sadegh Abadijou, Danial Safaei, Amir Hossein Mehdikhani

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Alzheimer's disease; neurological illness; dementia; machine learning; Magnetic Resonance Im-aging

Online: 16 June 2023 (07:28:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0246.v1

On the Safety of Implanted Breast Prostheses in Accidental Impacts

Gerardus Janszen, Michela Arnoldi, Valeriano Vinci, Marco Klinger, Luca Di landro

Subject: Chemistry And Materials Science, Biomaterials Keywords: breast implants; silicone prosthesis aging; accidental impacts; crash test; compression tests

Online: 5 June 2023 (05:38:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2235.v1

New Insights into the Enhancement Effect of Exogenous Calcium on Biochar Stability during Its Aging in Farmland Soil

Hongyan Nan, Yunqiu Jiang, Weiqi Zhou, Ling Zhao, Fan Yang

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: Biochar aging; Ca-rich biochar; Carbon stability; Farmland soil; Carbon sequestration

Online: 31 May 2023 (11:18:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202303.0088.v1

IoT-based Technologies for Addressing the Unique Healthcare Needs of the Elderly Population

Syed Adnan Ali, Rehan Khan

Subject: Computer Science And Mathematics, Information Systems Keywords: IoT; geriatric healthcare; IoMT; biomedical devices; telemedicine; remote monitoring; aging population

Online: 6 March 2023 (04:20:47 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202301.0334.v1

Serotonin Impact on Lifespan Longevity in Marine Annelid D.gyrociliatus

Elizaveta Fofanova

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: serotonin; pcpa; cystamine; dinophilida; invertebate models; aging; maternal serotonin; lifespan longevity

Online: 18 January 2023 (10:22:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0332.v1

Effect of Aging of Orthodontic Aligners in Different Storage Media on Force and Torque Generation: An in vitro Study

Tarek Elshazly, Diva Nang, Bijan Golkhani, Hanaa Elattar, Christoph Bourauel

Subject: Chemistry And Materials Science, Biomaterials Keywords: Biomechanics; Orthodontic force; Torque; Tooth Movement; Removable Thermoplastic Appliance; Aging; Aligners

Online: 19 December 2022 (09:10:51 CET)

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Preprint REVIEW | doi:10.20944/preprints202207.0160.v2

NIH SenNet Consortium: Mapping Senescent Cells in the Human Body to Understand Health and Disease

Patty J Lee, Philip Blood, Katy Börner, Judith Campisi, Feng Chen, Heike Daldrup-Link, Phil De Jager, Li Ding, Francesca E. Duncan, Oliver Eickelberg, Rong Fan, Toren Finkel, Vesna Garovic, Nils Gehlenborg, Carolyn Glass, Ziv Bar-Joseph, Pragati Katiyar, So-Jin Kim, Melanie Königshoff, George Kuchel, Haesung Lee, Jun H. Lee, Jian Ma, Qin Ma, Simon Melov, Kay Metis, Ana L. Mora, Nicolas Musi, Nicola Neretti, João F. Passos, Irfan Rahman, Juan Carlos Rivera-Mulia, Paul Robson, Mauricio Rojas, Ananda L. Roy, Birgit Schilling, Pixu Shi, Jonathan Silverstein, Vidyani Suryadevera, Jichun Xie, Jinhua Wang, An-Kwok Ian Wong, Laura Niedernhofer

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Cellular Senescence Network; Normal Aging; Senescence; Senescence-associated secretory phenotype; SenNet

Online: 15 September 2022 (12:52:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0061.v1

Sustainable Transformation of Digital Health Services- A Stakeholder Exploratory Case Study

Siyu Zhou, Ziling Ni, Atsushi Ogihara, Xiaohe Wang

Subject: Public Health And Healthcare, Health Policy And Services Keywords: sustainability; digital transformation; suitable for aging; service ecological theory; health service

Online: 6 May 2022 (07:45:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202204.0055.v1

Activity-Dependent Induction of Younger Molecular, Cellular and Organism Phenotypes

Thomas Lissek

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cell; biology; aging; medicine; transcription; activity; neurons; brain; immune system; muscle

Online: 7 April 2022 (04:24:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0026.v2

Telomere Shortening linked to Disability and Mitochondrial DNA Copy Number in Patients with Relapsing-Remitting Multiple Sclerosis

José Alfonso Cruz-Ramos, Gabriela del Carmen López-Armas, Eduardo Ignacio Díaz-Barba, Mónica Navarro-Meza, Miguel Ángel Macías-Islas, Ana Miriam Saldaña-Cruz, Abraham Zepeda-Moreno, Héctor Raúl Pérez-Gómez, Alejandra Martínez-Hernández, Martha Eloísa Ramos-Márquez

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Leukocyte telomere length; Mitochondrial DNA; Relapsing- Remittent Multiple Sclerosis; Disability; Aging

Online: 7 December 2021 (12:35:12 CET)

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Preprint REVIEW | doi:10.20944/preprints202107.0576.v1

Glassy Polymers – Diffusion, Sorption, Aging, and Applications

Raj Kumar Arya, Devyani Thapliyal, Jyoti Sharma, G. D. Verros

Subject: Engineering, Automotive Engineering Keywords: Glassy Polymers; Diffusion; Sorption; Physical Aging; Polymer Coatings; Gas Separation Membranes

Online: 26 July 2021 (13:52:57 CEST)

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Working Paper REVIEW

Appropriate Technologies to Accompany Sunscreens in the Battle Against Ultraviolet, Superoxide and Singlet Oxygen

Paolo Giacomoni

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Ultraviolet; superoxide; singlet Oxygen; cell blebbing; skin aging; peroxidative cascade; antioxidants

Online: 21 October 2020 (10:32:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0268.v1

Rapid Senectome and Alternative Splicing miRNAs Changes with the Relaxation Response: A One Year Follow-Up Study

Carlo Dal Lin, Mariela Marinova, Laura Brugnolo, Giorgio Rubino, Mario Plebani, Sabino Iliceto, Francesco Tona

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: cardiovascular disease; inflammation; aging; senectome, telomerase; alternative splicing; relaxation response; microRNA

Online: 12 July 2020 (16:57:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201912.0338.v2

Effect of Artificial Aging Treatment and lubrication Modes on the Machinability of A356 Cast Alloys

Mohamed Amine Alliche, Abdelhakim Djebara, Yasser Zedan, Victor Songmene

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: aluminum alloys; artificial aging; drilling; surface quality; cutting fluid; burr formation

Online: 27 March 2020 (02:54:29 CET)

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Preprint REVIEW | doi:10.20944/preprints201911.0190.v1

Epigenetic Signalling and RNA Regulation in Cardiovascular Diseases

Alessia Mongelli, Sandra Atlante, Tiziana Bacchetti, Fabio Martelli, Antonella Farsetti, Carlo Gaetano

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: epigenetics; nucleic acids; RNA; DNA; cardiovascular disease; chronic disease; aging, metabolism

Online: 16 November 2019 (00:59:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0133.v2

Age- and Genotype-Specific Effects of the Angiotensin-Converting Enzyme Inhibitor Lisinopril on Mitochondrial and Metabolic Parameters in Drosophila melanogaster

Karis A. Ederer, Kelly Jin, Sarah Bouslog, Lu Wang, Greg S. Gorman, Glenn C. Rowe, Peter Abadir, Daniel Raftery, Douglas Moellering, Daniel Promislow, Patricia Jumbo-Lucioni, Maria De Luca

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: aging; angiotensin-converting enzyme inhibitors; nutrient metabolism; genetic background; nutritional stress

Online: 29 October 2018 (10:33:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints201709.0082.v1

Dose-Dependent Effects of Oral Tyrosine Administration on Plasma Tyrosine Levels and Cognition in Aging

Ondine van de Rest, Mirjam Bloemendaal, Rianne de Heus, Esther Aarts

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: tyrosine; dose-response; aging; working memory; plasma amino acids; catecholamines; dopamine

Online: 18 September 2017 (15:48:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201704.0102.v1

Age-Related Diseases as Vicious Cycles

Aleksey V. Belikov

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: aging; age-related disease; mortality rate; positive feedback loop; vicious cycle

Online: 18 April 2017 (02:45:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.2244.v1

Top 5 Deadly Cybersecurity Threats to Kingdom of Saudi Arabia

Mariam Alkhalifa, Maha Aljaafari, Saira Muzafar

Subject: Computer Science And Mathematics, Computer Science Keywords: Cyber Crime; Anti-Cybercrime Law; KSA; Ransomware; Dark Web

Online: 30 August 2024 (15:46:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0049.v1

An Acid Responsive Fluorescent Molecule for Erasable Anti-Counterfeiting

Jiabao Liu, Xiangyu Gao, Qingyu Niu, Mingyuan Jin, Yijin Wang, Thamraa Alshahrani, He-Lue Sun, Banglin Chen, Zhiqiang Li, Peng Li

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: aggregation-induced emission; stimuli-responsive luminescence; diaminotriazine; anti-counterfeiting

Online: 2 August 2024 (03:38:25 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202406.1071.v1

A Case of Autoimmune Acute Disseminated Encephalomyelitis in an Adult Female with Systemic Lupus Erythematosus

Yousuf Sherwani, Ayham Alsaab, Mohan Sengodan

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: autoimmune diseases; demyelinating; brain; anti dna antibodies; rituximab; IVIG

Online: 17 June 2024 (08:34:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0051.v1

Exploring Folklore Ecuadorian Medicinal Plants and Their Bioactive Components Focusing on Antidiabetic Potential: An Overview

Soham Bhattacharya, Neha Gupta, Adéla Flekalová, Salomé Gordillo-Alarcón, Viviana Espinel-Jara, Eloy Fernández-Cusimamani

Subject: Biology And Life Sciences, Life Sciences Keywords: antidiabetic; anti-hyperglycaemic; bio-active compound; hypoglycaemic; medicinal plant

Online: 1 April 2024 (12:40:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1486.v1

Design and Synthesis of Novel Amino and Acetamidoaurones with Antimicrobial Activities

Attilio Di Maio, Hamza Olleik, Elise Courvoisier-Dezord, Sophie Guillier, Fabienne Neulat-Ripoll, Romain Haudecoeur, Jean-Michel Bolla, Magali Casanova, Jean-François Cavalier, Stéphane Canaan, Valérie Pique, Yolande Charmasson, Elias Baydoun, Akram Hijazi, Josette Perrier, Marc Maresca, Maxime Robin

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Aurone; anti-bacterial agents, cytotoxicity tests; structure-activity relationship

Online: 26 February 2024 (15:49:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0063.v2

Effect of Essential oil Components on the Activity of Steroidogenic Cytochromes P450

Katyayani Sharma, Angelo Lanzilotto, Jibira Yakubu, Søren Therkelsen, Clarissa Daniela Voegel, Therina Du Toit, Flemming Steen Jørgensen, Amit V. Pandey

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: EDCs; Prostate cancer; CYP17A1; steroidogenesis; DHEA; anti cancer drugs

Online: 29 January 2024 (09:10:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.2310.v1

Anti-Inflammatory Effects of Idebenone Attenuate Systemic Inflammatory Diseases by Suppressing NF-κB Activation

Yumin Choi, Young-Lai Cho, Sujeong Park, Minkyung Park, Keun-Seok Hong, Young Jun Park, In-Ah Lee, Su Wol Chung, Heedoo Lee, Seon-Jin Lee

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Anti-inflammation, Inflammatory disease model, NF-κB, ROS, Idebenone

Online: 29 December 2023 (13:38:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1873.v1

Preparation of pH-Responsive BTA@DME/PDA Microcapsules and Their Application in Anti-corrosion Coatings

Beiyao Zhang, Mingjun Zhang, Jiaying Jin, Shupei Liu, Jin song Rao, Haiyan Li

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: diatomite nanoporous microcontainers; pH-responsive microcapsules; anti-corrosion coatings

Online: 25 December 2023 (11:08:28 CET)

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