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Preprint ARTICLE | doi:10.20944/preprints202403.1768.v1

Pilot Testing of Useful Tools Validity for Frailty Assessment in Greece: Translated PRISMA-7 Tool, Modified Fried Criteria and Clinical Frailty Scale

George Soulis, Efstathia Kyriakopoulou, Aristea Leventouri, Eleni Zigkiri, Vasiliki Efthymiou, Zikos Kentros, Anastasia Koutsouri

Subject: Public Health And Healthcare, Primary Health Care Keywords: Frailty; Greek Translation of PRISMA-7; Modified Fried criteria; Greek version of Clinical Frailty Scale

Online: 28 March 2024 (12:12:26 CET)

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The importance of frailty in older people is getting constant recognition as an important aspect both in terms of public health, as well in personal level for the appropriate management of an older person health condition. This is reflected by the continuously increasing number of research studies carried out in several settings across different countries. Sometimes this is very solid, but in other cases there is a considerable gap in terms of accurate and well grounded documentation of frailty status. This is the case in Greece, where we are missing clinically validated tools to approach frailty. We are missing frailty screening tools, such as for instance PRISMA 7, the gold standard tool of Fried criteria is somehow problematic since the question referring to physical activity originates from a questionnaire that has not been translated and validated, while Clinical Frailty Scale has been validated for the translation but not for the capacity to detect frailty. Aim of this study is to validate these tools for their accuracy to detect frailty by using a measurable index of frailty, previously proposed for use in clinical studies: the Short Physical Performance Battery (SPPB). 74 male and female participants have been evaluated for their frailty status using different tools. We observed that PRISMA 7 translation detects frailty only when one question is removed at a cut-off of ≥ 2 and indicated a sensitivity of 88.1%, and specificity of 99.9% with a good correlation with SPPB measurements (r = 0.858; p < 0.001). When CFS was validated using SPPB it demonstrated a very good correlation (r = -0.838; p < 0.001 respectively) as it was the case for the modified Fried Criteria (r = -0.725; p < 0.001). All items demonstrated a good correlation between them. We can here propose that we can accurately assess frailty status in the community setting by using a modified version of Fried criteria, Clinical Frailty Scale translation in Greek and we can screen for frailty by using the Greek translation of PRISMA 7 only after removing the item 6 of the questionnaire.

Preprint ARTICLE | doi:10.20944/preprints202403.0136.v1

Integrating Genome-Scale Metabolic Models with Patient Plasma Metabolome to Study Endothelial Metabolism In Situ

Fernando Silva-Lance, Isabel Montejano-Montelongo, Eric Bautista, Lars K. Nielsen, Pär I. Johansson, Igor Marin de Mas

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Metabolic Network Analysis; Genome-Scale Metabolic Models; Exo-Metabolomics Integration; Sampling Algorithms; Endothelial Cell Metabolism

Online: 4 March 2024 (14:02:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1569.v1

Experimental and Numerical Study of the Effect of Carbonate Rock Dissolution on Absolute Permeability of 408 Heterogeneous and Naturally Fractured Samples

Zhibek K. Akasheva, Bakytzhan K. Assilbekov, Darezhat A. Bolysbek, Berik A. Iskakov, Kenbai Sh. Uzbekaliyev, Gani I. Issayev

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: Absolute permeability; pore-scale modeling; percolation threshold porosity; dissolution; power law; X-ray microcomputed tomography

Online: 24 November 2023 (11:27:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1702.v1

Research on the Shock Environment Characteristics of Marine Diesel Engine Based on a Large Floating Impact Platform

Yu Zhang, Jun Li, Chun hui Zhang, Wei Chen, Zhi peng Du, Xiao bin Li

Subject: Engineering, Marine Engineering Keywords: large-scale floating shock platform (LFSP); shock environments; underwater explosion; marine diesel engines; shock spectra

Online: 26 October 2023 (11:40:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1180.v1

Piloting Bioethanol Production from Source-Separated Food Waste Boosts TRL

Fotis Chatzimaliakas, Diogenis Christianides, Dimitris Malamis, Sofia Mai, Elli Maria P. Barampouti

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: Source-separated kitchen waste; Simultaneous saccharification and fermentation; Bioethanol yield; Pilot-Scale; Fresh food waste

Online: 22 October 2023 (09:05:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0774.v1

Comparative Study of Two Commercial Brain Volumetry Software: Assessing Medial Temporal Lobe Atrophy

Jimin Kim, Se Won Oh, Jee-Young Kim, Regina EY Kim, Donghyeon Kim

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’s disease; volumetry software; MRI; medial temporal lobe atrophy; Scheltens’ scale; NeuroQuant®; Aqua®

Online: 12 October 2023 (05:35:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0329.v1

Marine Cultural Target Detection for Underwater Robotics Based on Deep Aggregation Network with Deformation Convolution

Yutuo Yang, Wei Liang, Daoxian Zhou, Yinlong Zhang, Gaofei Xu

Subject: Computer Science And Mathematics, Robotics Keywords: autonomous underwater vehicle (AUV); underwater target detection; deformable convolution; multi-scale deep aggregation; attention mechanism

Online: 6 October 2023 (11:51:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1174.v1

ENN: Hierarchical Image Classification Ensemble Neural Network for Large-Scale Automated Detection of Potential Design Infringement

Chan Jae Lee, Seong Ho Jeong, Young Yoon

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Design Right Infringement; Deep Learning; Ensemble Learning; Image Classification; Object Detection; Large-Scale Detection System

Online: 19 September 2023 (03:03:46 CEST)

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This paper presents a two-stage hierarchical neural network using image classification and object detection algorithms as key building blocks for a system that automatically detects a potential design right infringement. This neural network is trained to return the Top-N original design right records that highly resemble the input image of a counterfeit. Design rights specify the unique aesthetic characteristics of a product. Due to the rapid change of trends, new design rights are continuously generated. This work proposes an Ensemble Neural Network (ENN), an artificial neural network model that aims to deal with a large amount of counterfeit data and design right records that are frequently added and deleted. At first, we performed image classification and objection detection learning per design right using the existing models with a proven track record of high accuracy. The distributed models form the backbone of the ENN and yield intermediate results aggregated at a master neural network. This master neural network is a deep residual network paired with a fully connected network. This ensemble layer is trained to determine the sub-models that return the best result for a given input image of a product. In the final stage, the ENN model multiples the inferred similarity coefficients to the weighted input vectors produced by the individual sub-models to assess the similarity between the test input image and the existing product design rights to see any sign of violation. Given 84 design rights and the sample product images taken meticulously under various conditions, our ENN model achieved average Top-1 and Top-3 accuracies of 98.409% and 99.460%, respectively. Upon introducing new design rights data, a partial update of the inference model was done an order of magnitude faster than the single model. ENN maintained a high level of accuracy as it scaled out to handle more design rights. Therefore, the ENN model is expected to offer practical help to the inspectors in the field, such as the customs at the border that deal with a swarm of products.

Preprint ARTICLE | doi:10.20944/preprints202309.0676.v1

Remaining Useful Life Prediction of Rolling Bearings Based on Multi-scale Permutation Entropy and SSA-LSTM

Hongju Wang, Xi Zhang, Mingming Ren, Tianhao Xu, Chengkai Lu, Zicheng Zhao

Subject: Engineering, Mechanical Engineering Keywords: remaining useful life; maximum correlation kurtosis deconvolution; multi-scale permutation entropy; long short-term memory

Online: 11 September 2023 (11:30:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0762.v1

Burden of Care of Family Caregivers for People Diagnosed with Serious Mental Disorders in a Rural Health District in Kwa-Zulu-Natal, South Africa

Jabulile Thembelihle Ndlovu, Kebogile Elizabeth Mokwena

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Zarit Burden Interview scale; burden of care; home care giving; severe mental illness; rural setting

Online: 10 August 2023 (05:32:21 CEST)

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Jabulile Ndlovu1 and Kebogile Mokwena1, 2 1 Department of Public Health, Sefako Makgatho Health Sciences University, Pretoria, South Africa 2 Research Chair in Substance abuse and population Mental Health, Sefako Makgatho Health Sciences University, Pretoria, South Africa Corresponding author: jabulilendlovu5@gmail.com Abstract An estimated 6% of the world population has serious mental illness, with one in four families having a member with some form of psychiatric disorder, who are mostly cared for by their relatives within a family setting. Although caregiving in a home setting is reported to be associated with significant mental distress, the burden of such distress is rarely measured. The purpose of this study was to quantify the burden of care among family caregivers of relatives with serious mental disorders, as well as to explore possible association between the caregiver burden of care and a range of caregiver and Mental Health Care User (MHCU) variables in a rural district in Kwa-Zulu Natal, South Africa. The Zarit Burden Interview (ZBI) scale was used to collect data from 357 caregivers, and STATA 14 was used to analyze data. The ages of the sample ranged from 18 to 65, with a mean of 50.29, and the majority (86%) were female and unemployed (83%). The ZBI scores ranged from 8 to 85, with a mean of 41.59. The majority (91%) tested positive for caregiver burden of care, which ranged from mild to severe. Using the Pearson Chi-square test of association (p=0.05), variables that were significantly associated with the burden of care were clinically related (caregiver self-reported depression, MHCU diagnosis, recent relapse of the MHCU), socio-economic (caregiver family monthly income, MHCU disability grant status and MHCU employment status) and socio-demographic (MHCU gender and MHCU level of education). The prevalence of burden of care is high and severe, and scarcity of resources in families and communities contribute to the high burden of care in these rural communities.

Preprint ARTICLE | doi:10.20944/preprints202307.0346.v1

Characterisation of the Contact between Cross-Country Skis and Snow: On the Multi-Scale Interaction between Ski Geometry and Ski-Base~Texture

Kalle Kalliorinne, Gustav Hindér, Joakim Sandberg, Roland Larsson, Hans-Christer Holmberg, Andreas Almqvist

Subject: Engineering, Mechanical Engineering Keywords: Cross-Country Skiing; Sports Equipment; Multi-Scale; Contact Mechanics; Ski-Camber Profile; Ski-Base Texture

Online: 5 July 2023 (15:37:49 CEST)

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At the highest level of endurance sports, the differences in finishing times are small, so equipment is constantly being constantly improved to enhance the athletes' performance. For instance, one dominant resistive force in connection with cross-country skiing is the friction between the skis and snow and since the 1930s, research designed to understand and reduce this friction has been ongoing. The mechanisms involved in ski-snow friction include compaction, micro-ploughing, adhesion, viscosity, and water-bridging. Of these, adhesive and viscous friction have been most studied, while much less is presently known about compaction, micro-ploughing, and water-bridging. At the macro-scale, the ski-camber profile plays a key role in determining whether, with respect to friction, a particular cross-country ski is suitable for use under a given set of conditions. Through its influence on where ski-snow contact occurs, this ski-camber profile has a profound impact on adhesive and viscous friction, micro-ploughing, the formation of water bridges, and the rate of compaction. Different contact zones with different apparent areas of contact and pressure have been found to be most suitable for different conditions. In addition, the micro-scale texture of the ski base is also an important determinant of ski-snow friction. Topographical measurements of this texture can be achieved with white-light interferometer and recent characterisation has focused on the mechanical properties of contact. In numerous tribological studies the interactions between features at different scales are modelled. In most tribological systems, features on several scales influence friction and ski-snow contact is certainly no exception. Accordingly, the current investigation was designed to evaluate the multi-scale properties of different combinations of two skis with two different base textures. The real area of contact and the average interfacial separation and total average reciprocal interfacial separation between the ski and snow were taken into consideration. We found that different macro- and micro-scale properties of the ski favour different mechanisms of friction. Both the profile of the ski camber and texture of the base play decisive roles in determining viscous friction. At the same time, the texture of the ski base exerts a greater impact on the average real contact pressure, real contact area and minimal average interfacial separation between the ski and snow than does the ski-camber profile.

Preprint ARTICLE | doi:10.20944/preprints202306.0780.v1

A Lightweight Detection Algorithm for Unmanned Surface Vehicles Based on Multi-Scale Feature Fusion

Lei Zhang, Xiang DU, Renran Zhang, Jian Zhang

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: unmanned surface vehicle; multi-scale feature; lightweight detection algorithm; dynamic head; coordinate convolution; YOLOv7-tiny

Online: 12 June 2023 (07:09:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0094.v1

Sustainable Metabolic Engineering Design Development Employing a Complex Objective Function

Reinis Muiznieks, Elina Dace, Egils Stalidzans

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: economic sustainability; environmental sustainability; social sustainability; genome scale metabolic model; metabolic engineering; growth coupled production

Online: 3 May 2023 (04:32:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0249.v1

Validation of the Cooling Model for TMCP Processing of Steel Sheets with Oxide Scale by Industrial Experiment Data

Emmanuil Beygelzimer, Yan Beygelzimer

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: rolled flat products; accelerated cooling; temperature; mathematical model; oxide scale; Ther-mo-Mechanical Controlled Process

Online: 17 June 2022 (05:14:37 CEST)

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Working Paper REVIEW

Machine Learning of Spatial Data

Behnam Nikparvar, Jean-Claude Thill

Subject: Social Sciences, Geography, Planning And Development Keywords: spatial machine learning; spatial dependence; spatial heterogeneity; scale; spatial observation matrix; learning algorithm; deep learning

Online: 6 August 2021 (14:18:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0569.v1

Effects of Clinical Characteristics on Sleep Quality in Patients with Chronic Temporomandibular Disorders

Yeon-Hee Lee, Q-Schick Auh, Jung-Sub An, Tae Kim

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Sleep quality; Chronic pain; Temporomandibular disorder; Pittsburgh Sleep Quality Index; STOP-Bang; Epworth Sleepiness Scale

Online: 23 June 2021 (11:11:14 CEST)

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Objectives: This study aimed to investigate and compare sleep quality between patients with chronic temporomandibular disorder and healthy controls, and to analyze the association of sleep quality with disease characteristics, obstructive sleep apnea risk factors, and excessive daytime sleepiness. Methods: Chronic temporomandibular disorder patients (n=503) and 180 age- and sex-matched healthy controls were included, who completed well-organized clinical report and answered questions on sleep quality (Pittsburgh Sleep Quality Index), sleep apnea risk factors (STOP-Bang questionnaire), and excessive daytime sleepiness (Epworth sleepiness scale). Results: Mean global Pittsburgh Sleep Quality Index scores were significantly higher in the patients (6.25±2.77) than in healthy controls (6.25±2.77) (p<0.001). Poor sleep was significantly more prevalent in the patient group (56.9%) than in healthy controls (22.2%) (p<0.001). Compared with healthy controls, chronic temporomandibular disorder patients had a higher likelihood of obstructive sleep apnea. (STOP-Bang total score ≥3; 7.2% vs. 16.1%; p<0.01) and higher excessive daytime sleepiness (Epworth sleepiness scale score ≥10; 12.8% vs. 19.7%; p<0.05). Age (odds ratio=2.551; p<0.001), female sex (odds ratio=1.885; p=0.007), total Epworth sleepiness scale score (odds ratio=1.839; p=0.014), and headache attributed to temporomandibular disorder (odds ratio=1.519; p=0.049) were the most powerful predictors of poor sleep (global Pittsburgh Sleep Quality Index score ≥5) in chronic temporomandibular disorder patients. Conclusion: Chronic temporomandibular disorder patients had sleep quality impairment. Various factors, including peripheral and central factors, affect the patient's sleep quality. Therefore, in addition to sleep quality and sleep-related problems, the underlying central mechanism for poor sleep quality should be assessed when treating chronic temporomandibular disorder patients.

Preprint ARTICLE | doi:10.20944/preprints202105.0282.v2

Design Optimization of Centrifugal Microfluidic "Lab-on-a-Disc" Systems towards Fluidic Larger-Scale Integration

Jens Ducrée

Subject: Computer Science And Mathematics, Software Keywords: centrifugal microfluidics, Lab-on-a-Disc, large-scale integration, reliability, tolerances, band width, packing density

Online: 8 June 2021 (12:07:35 CEST)

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Working Paper ARTICLE

Single Image Rain Removal Based on Multi-Scale and Channel Attention Mechanism

Qiuling Liu, Gang Zhou, Zhenhong Jia

Subject: Computer Science And Mathematics, Computer Science Keywords: Single image deraining; Multi-layer Laplacian pyramid; Multi-scale feature extraction module; Channel attention module.

Online: 31 May 2021 (11:41:25 CEST)

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Working Paper ARTICLE

A New 3D Geological Modeling Method Based On Remote Sensing and Its Application in Ya 'an Area Sichuan Province

Zhaoyang Ma, Lihai Zhang, Yan Wang, Guifan Zhu, Yinping Liang

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Multi-source heterogeneity; remote sensing; large-scale high-precision modeling; grid division; geostatistics; spatial interpolation

Online: 20 January 2021 (16:19:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0409.v1

Personalized Biometrics of Physical Pain Agree with Its Psychological Perception by Participants with Sensory Over Responsivity

Jihye Ryu, Tami Bar-Shalita, Yelena Granovsky, Irit Weissman-Fogel, Elizabeth B. Torres

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: EEG; pain biometrics; stochastic analyses; micro-movements spikes; sensory over responsivity; standardized scale; personalized pain

Online: 16 December 2020 (13:19:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0298.v2

Cosmic Ray Extremely Distributed Observatory

Piotr Homola, Dmitriy Beznosko, Gopal Bhatta, Łukasz Bibrzycki, Łukasz Bratek, Michalina Borczyńska, Nikolay M. Budnev, Dariusz Burakowski, David Edwin Alvarez-Castillo, Kevin Almeida Cheminant, Aleksander Ćwikła, Punsiri Dam-o, Niraj Dhital, Alan Duffy, Piotr Głownia, Krzysztof Gorzkiewicz, Dariusz Góra, Alok C. Gupta, Zuzana Hlávková, Martin Homola, Joanna Jałocha, Robert Kamiński, Michał Karbowiak, Marcin Kasztelan, Renata Kierepko, Marek Knap, Péter Kovács, Szymon Kuliński, Bartosz Łozowski, Marek Magryś, Mikhail V. Medvedev, Justyna Mędrala, Jerzy W. Mietelski, Justyna Miszczyk, Alona Mozgova, Antonio Napolitano, Vahab Nazari, Y. Jack Ng, Michał Niedźwiecki, Cristina Oancea, Bogusław Ogan, Gabriela Opiła, Krzysztof Oziomek, Maciej Pawlik, Marcin Piekarczyk, Bożena Poncyljusz, Jerzy Pryga, Matías Rosas, Krzysztof Rzecki, Jilberto Zamora-Saa, Katarzyna Smelcerz, Karel Smolek, Weronika Stanek, Jarosław Stasielak, Slawomir Stuglik, Jolanta Sulma, Oleksandr Sushchov, Manana Svanidze, Kyle Tam, Arman Tursunov, José-M. Vaquero, Tadeusz Wibig, Krzysztof W. Woźniak

Subject: Physical Sciences, Nuclear And High Energy Physics Keywords: cosmic rays; cosmic ray ensembles; extensive air showers; large scale cosmic ray correlations; CREDO Collaboration

Online: 15 October 2020 (16:13:43 CEST)

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Working Paper ARTICLE

Effect of Interlayer Cooling Time, Constraint and Tool Path Strategy on Deformation of Large Components made by Laser Metal Deposition with Wire

Yousub Lee, Yashwanth Bandari, Peeyush Nandwana, Brian Gibson, Brad Richardson, Srdjan Simunovic

Subject: Engineering, Mechanical Engineering Keywords: large-scale additive manufacturing; interlayer cooling time; tool path optimization; part deformation; Ti-6Al-4V

Online: 10 November 2019 (09:04:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints201803.0010.v1

The Effect of Propeller Scaling Methodology on the Performance Prediction

Stephan Helma, Heinrich Streckwall, Jan Richter

Subject: Engineering, Marine Engineering Keywords: propeller scale effects; propeller open-water efficiency; surface roughness; equivalent profile; strip method; betai method

Online: 1 March 2018 (15:58:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.1943.v1

Blood-Brain Barrier Integrity Disruption is Associated to both Chronic Vascular Risk Factors and White Matter Hyperintensities

James Xiao Yuan Chen, Ashwati Vipin, Gurveen Kaur Sandhu, Yi Jin Leow, Fatin Zahra Zailan, Pricilia Tanoto, Ee Soo Lee, Khang Leng Lee, Christine Cheung, Negaenderan Kandiah

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: cerebral small vessel disease; blood-brain barrier; cardiovascular risk factors; white matter hyperintensity; transendothelial electrical resistance assay

Online: 25 September 2024 (08:26:47 CEST)

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Preprint ESSAY | doi:10.20944/preprints202408.2054.v1

IV-YOLO: A Lightweight Dual-Branch Object Detection Network

Xin Yan, Dan Tian, Dong Zhou, Chen Wang, Wenshuai Zhang

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: Dual-branch image object detection; IV-YOLO; Bi-directional pyramid feature fusion; Attention mechanism; Small target detection

Online: 28 August 2024 (12:30:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0770.v1

Clinical Role of Adjuvant Chemotherapy after Sublobar Resection for Non-small Cell Lung Cancer ≤ 20 mm with Lymph Node Metastases: A Propensity-Matched Analysis of the National Cancer Database

Shinkichi Takamori, Junjia Zhu, Asato Hashinokuchi, Takefumi Komiya

Subject: Medicine And Pharmacology, Surgery Keywords: non-small cell lung cancer; surgery; adjuvant chemotherapy; sublobar resection; lymph node metastasis

Online: 13 May 2024 (11:09:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0646.v1

Comparison of Small Blood Vessels Diameter with Intravascular Ultrasound and Coronary Angiography for Guidance of Percutaneous Coronary Intervention

Sergio Adrián Zuñiga-Mendoza, Emanuel Zayas-Diaz, Victoria del Rosario Armenta-Velazquez, Ana Aurora Silva-Baeza, Juan Jorge Beltran-Ochoa, Misael A. Medina-Servin, Maria G. Zavala-Cerna

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Cardiovascular disease; coronary artery disease; Percutaneous coronary intervention; Coronary angiography; Intravascular ultrasound; small vessel coronary artery disease.

Online: 10 May 2024 (12:17:54 CEST)

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Major cardiovascular events (MACE) are a cause of major mortality worldwide. The narrowing and blockage of coronary arteries with atherosclerotic plaques is diagnosed and treated with percutaneous coronary intervention (PCI). During this procedure, coronary angiography (CAG) remains the most widely used guidance modality for the evaluation the affected blood vessel diameter in order to decide if intervention with stent colocation is suitable, where small blood vessels (< 2.75 mm) are majorly left untreated; however, small vessel coronary artery disease (SvCAD) is a significant risk factor for recurrence of MACE, and there are some limitations to the use of CAG that could be improved with the use of newer techniques such as intravascular ultrasound (IVUS), although at higher costs, which might explain their underuse. To address this discrepancy and identify specific cases for its use, we conducted a retrospective study in patients who underwent PCI for MACE with at least one small blood vessel affected. The affected small blood vessels’ diameter was obtained with both CAG and IVUS, additionally we underwent a multivariate analysis to identify risk factors associated with a change in diameter. We included information from 48 patients with mean + SD age of 69.1 + 11.9 years and 34% were masculine gender. We found a significant positive low correlation in diameter measurements of small blood vessels (r=0.1242 p=0.014). Mean diameter with CAG and IVUS was 2.1 mm (95% CI 1.9-2.2), and 2.8 (2.8-3.0) the estimated difference was of 0.8 mm (95 % CI 0.7-0.9). In total 37 (77%) of patients had a reclassification of their blood vessels from a small to medium (2.75-3.00 mm) in 21 cases, or even large (<3.00 mm) in 15 cases, after IVUS; this was important for the decision of intervention and stent collocation. The only variable associated with reclassification of blood vessels after adjusted in a multivariate analysis was DT2 (p=0 0.035). Our findings corroborate that blood vessels might appear smaller with CAG, especially in the diabetes population, therefore at least in these cases the use of IVUS is recommended over CAG.

Preprint REVIEW | doi:10.20944/preprints202405.0498.v1

Cerebral Microbleeds Associate with Brain Endothelial Cell Activation-Dysfunction and Blood-Brain Barrier Dysfunction-Disruption with an Increased Risk of Hemorrhagic and Ischemic Stroke That Is Capable of Exacerbating Neurodegeneration

Melvin Ray Hayden

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Alzheimers Disease; BBB; Cerebral microbleeds; Dementia; Hypertension; MRI; Neurovascular unit; cerebral small vessel disease; Transmission electron microscopy

Online: 8 May 2024 (12:47:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1781.v1

Synthesis and PET Imaging Biodistribution Studies of Radiolabeled Iododiflunisal, a Transthyretin Tetramer Stabilizer, Candidate Drug for Alzheimer’s Disease

Sameer M Joshi, Thomas C Wilson, Zibo LI, Sean Preshlock, Vanessa Gómez-Vallejo, Véronique Gouverneur, Jordi Llop, Gemma Arsequell

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Iododiflunisal; transthyretin tetramer stabilizer; small-molecule chaperone; amyloid beta; in vivo imaging; 18F; positron emission tomography (PET).

Online: 29 November 2023 (07:16:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0290.v1

Low Molecular Weight Inhibitors Targeting the RNA-Binding Protein HuR

Benjamin Philipp Joseph, Verena Weber, Lisa Knüpfer, Alejandro Giorgetti, Mercedes Alfonso-Prieto, Sybille Krauß, Paolo Carloni, Giulia Rossetti

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: RNA-binding protein; human antigen R (HuR); high-throughput virtual screening; small molecule inhibitors; RNA pulldown assay

Online: 3 August 2023 (10:11:15 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202307.0591.v1

Acceleration Analysis of Canned Motor for SMR Reactor Coolant Pumps

Timothy Kanyolo, Harold Oyando, Choong-koo Chang

Subject: Engineering, Electrical And Electronic Engineering Keywords: motor acceleration study; reactor coolant pump (RCP); canned motors; small modular reactor (SMR); variable frequency drive (VFD)

Online: 10 July 2023 (10:31:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0327.v3

Logic-Based Modeling and Drug Repurposing for the Prediction of Novel Therapeutic Targets and Combination Regimens against E2F1-Driven Melanoma Progression

Nivedita Singh, Faiz M. Khan, Lakshmi Bala, Julio Vera, Olaf Wolkenhauer, Brigitte Pützer, Stella Logotheti, Shailendra K. Gupta

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Melanoma; Core regulatory network; in silico perturbationSystems pharmacology; Boolean model; Small molecule inhibitors; Virtual screening; ADME; E2F1

Online: 12 June 2023 (10:22:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0911.v1

Age Profiles for SARS-CoV-2 Variants in England and Wales and States of the USA (2020 to 2022): Impact on All-Cause Mor-Tality

Rodney P Jones, Andrey Ponomarenko

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID–19; all-cause mortality; single year of age; gender; complex system; pathogen interference; seasonality; small RNAs

Online: 12 May 2023 (09:01:29 CEST)

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Since 2020 COVID-19 has caused serious mortality around the world. Given the ambiguity in es-tablishing COVID-19 as the direct cause of death we first investigate the effects of age and sex upon all-cause mortality during 2020 and 2021 in England and Wales. Since infectious agents have their own unique age profile for death, we explore several methods to adjust single year of age deaths in England and Wales during 2019 (the pre-COVID-19 base year) to a pathogen-neutral single year of age baseline. This adjusted base year is then used to confirm the widely reported higher deaths in males for most ages above 43 years in both 2020 and 2021. During 2020 (+ COVID-19 but no vac-cination) both male and female population-adjusted deaths were significantly increased above age 35. A significant reduction in all-cause mortality among both males and females aged 75+ could be demonstrated in 2021 during widespread COVID–19 vaccination, however, below age 75 deaths progressively increased. This finding arises from a mix of vaccination and year of age profiles of deaths for the different SARS-CoV-2 variants. In addition, specific effects for age around puberty were demonstrated where females had higher deaths rather than males. There is evidence that year-of-birth cohorts may also be involved, indicating that immune priming to specific pathogen outbreaks in the past may lead to lower deaths for some birth cohorts. To specifically identify the age profile for the COVID-19 variants in 2020 to 2023, we employ the proportion of total deaths at each age which are potentially due to or ‘with’ COVID-19. The original Wuhan strain, and the Alpha variant show somewhat limited divergence in the age profile with the Alpha variant shifted to a moderately higher proportion of deaths below age 84. The Delta variant specifically targeted persons below age 65. The Omicron variants showed significantly lower proportion of overall mortality, with markedly higher relative proportion of deaths above age 65 steeply increasing with age to a maximum around 100 years of age. A similar age profile for the variants can be seen in the age-banded deaths in US states – although slightly obscured by using age bands rather than single year of age. However, the US data shows that higher male deaths are greatly dependent on age and the COVID-variant. Deaths determined as ‘due to’ COVID-19 (as opposed to ‘involving’ COVID-19) in England and Wales were especially over-estimated in 2021 relative to the change in all-cause mortality. This arose as a by-product of an increase in COVID-19 testing capacity in late 2020. Potential structure-function mechanisms for the year of age specificity of SARS-CoV-2 var-iants are discussed. The question is posed as to whether vaccines based on different variants carry the specific age profile through into the vaccine.

Preprint REVIEW | doi:10.20944/preprints202304.0538.v1

The Roles of Ral-Interacting Protein 76 and Vascular Endothelial Growth Factor in the Ovarian Corpus Luteum and Tumor Microenvironment

Tae-Hee Min, Seunghyung Lee

Subject: Biology And Life Sciences, Life Sciences Keywords: Ral-interacting protein 76; vascular endothelial growth factor; small GTPase; hypoxia-inducible factor-1; corpus luteum; tumor

Online: 19 April 2023 (04:10:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202202.0316.v1

The Selenoprotein Glutathione Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities

Kamari Weaver, Rachid Skouta

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Selenoprotein Glutathione Peroxidase 4 (GPX4); Reduced Glutathione (GSH); ferroptosis; lipid peroxidation; ferroptosis modulators; small molecules targeting GPX4

Online: 24 February 2022 (12:05:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0732.v1

A Real-World, Observational, Prospective Study to Assess the Molecular Epidemiology of Epidermal Growth Factor Receptor (EGFR) Mutations upon Progression on or after First-Line Therapy with a First or Second Generation EGFR Tyrosine Kinase Inhibitor in EGFR Mutation-Positive Locally Advanced or Metastatic Non-small Cell Lung Cancer: The ‘LUNGFUL’ Study

Giannis Mountzios, Anna Koumarianou, Alexandros Bokas, Dimitrios Mavroudis, Epaminondas Samantas, Evangelos Georgios Fergadis, Helena Linardou, Panagiotis Katsaounis, Elias Athanasiadis, Michalis V. Karamouzis, George Pentheroudakis, Sofia Lampaki, Marios Froudarakis, Eleni-Isidora A. Perdikouri, Alvertos Somarakis, Foteini Papageorgiou, Zoe Paparepa, Aristeidis Nikolaou, Konstantinos N. Syrigos

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Epidermal Growth Factor Receptor (EGFR); mutations, EGFR tyrosine kinase inhibitor; molecular epidemiology; Non-small-cell lung cancer

Online: 28 April 2021 (07:55:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202012.0288.v1

Desmoplastic Small Round Cell Tumor: A Review of Main Molecular Abnormalities and Emerging Therapy

Celso Abdon Mello, Fernando Augusto Batista Campos, Tiago Goss Santos, Maria Leticia Gobo Silva, Giovana Tardin Torrezan, Felipe D´Almeida Costa, Maria Nirvana Formiga, Ulisses Nicolau, Antonio Geraldo Nascimento, Cassia Silva, Suely Nakagawa, Maria Paula Curado, Ademar Lopes, Samuel Aguiar

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: desmoplastic small round cell tumor; treatment; prognosis; surgery; radiotherapy; chemotherapy; tyrosine kinase receptor; target therapy; rare disease

Online: 11 December 2020 (15:53:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202001.0252.v1

RIP1 is Novel Component of γ-Ionizing Radiation-Induced Invasion of Non-Small Cell Lung Cancer Cells

Jeong Hyun Cho, A-Ram Kang, Na-Gyeong Lee, Jie-Young Song, Sang-Gu Hwang, Dae-Hee Lee, Hong-Duck Um, Jong Kuk Park

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: signal transduction; γ-ionizing radiation; cancer invasion; non-small cell lung cancer; epithelial-mesenchymal transition; tumor microenvironment

Online: 22 January 2020 (03:04:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202410.1895.v1

As One and Many: Relating Individual and Emergent Group-Level Generative Models in Active Inference

Peter Thestrup Waade, Christoffer Lundbak Olesen, Jonathan Ehrenreich Laursen, Samuel William Nehrer, Conor Heins, Karl Friston, Christoph Mathys

Subject: Biology And Life Sciences, Behavioral Sciences Keywords: Active Inference; Free Energy Principle; Markov Blanket; Predictive Processing; Cognitive Modelling; Multi-scale; Collective Intelligence; Emergence

Online: 24 October 2024 (10:15:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints202410.1240.v1

The Untapped Potential of Hairy Root Cultures and Their Multiple Applications

Iman Mirmazloum, Aleksandar K. Slavov, Andrey S. Marchev

Subject: Biology And Life Sciences, Plant Sciences Keywords: Specialized metabolites; hairy roots; Rhizobium rhizogenes; elicitation; metabolic engineering, CRISPR/CAS9; bioprocessing; bioreactors; patents; industrial scale

Online: 16 October 2024 (09:40:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0777.v1

Delineating Ecological Functional Zones and Grades for Multi-Scale Ecosystem Management

Yan Zhang, Shuhan Liu, Peiheng Yu, Yanchi Lu, Yang Zhang, Jinting Zhang, Yiyun Chen

Subject: Environmental And Earth Sciences, Ecology Keywords: ecosystem services; ecological functional zones; tradeoffs and synergies; self-organizing feature mapping; multi-scale management ;

Online: 10 September 2024 (09:42:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1537.v1

Converting Candlenut Shell Waste into Graphene for Electrode Applications

Rikson Siburian, Kerista Tarigan, Yosia Gopas Oetama Manik, Fajar Hutagalung, Yatimah Alias, Yong Ching Chan, Boon Peng Chang, Jonathan Siow, Amanda Jiamin Ong, Jingfeng Huang, Suriati Paiman, Boon Tong Goh, Lisnawaty Simatupang, Ronn Goei, Alfred Iing Yoong Tok, Yahya Mohd Fakharul Zaman Raja, Fathan Bahfie

Subject: Engineering, Other Keywords: graphene; candlenut (Aleurites moluccanus) shell; Ce/graphene; carbon large scale production; energy storage electrodes

Online: 24 June 2024 (04:28:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1714.v1

Large-Scale Group Decision-Making Method with Public Participation and Its Application in Urban Management

Xiuhong Niu, Yongming Song, Zhongwen Xu

Subject: Business, Economics And Management, Business And Management Keywords: Large-scale group decision-making; Public participation; Multi-granular probabilistic linguistic preference relations; Consensus reaching process

Online: 27 May 2024 (13:07:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1203.v1

Computational Thinking Measurement of CS University Students

Raquel Hijón-Neira, Celeste Pizarro, John French, Daniel Palacios-Alonso, Emre Çoban

Subject: Computer Science And Mathematics, Computer Science Keywords: Computational Thinking; Programming; Performance-based assessment platform; Interactive web app; Evaluation methods; Psychometric scale; Students evaluation

Online: 20 May 2024 (10:11:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1419.v1

Gaining Insight Into Teenagers' Experiences of Pain After Laparoscopic Surgeries; A Prospective Study

Mihaela Visoiu, Jacques E. Chelly, Senthilkumar Sadhasivam

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Teenager Postoperative Pain; Visual Analog Pain Scale; Pain Behaviour; Pain Catastrophizing Thoughts; Anxiety; Mood; Laparoscopic Surgeries

Online: 26 February 2024 (11:41:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0371.v1

Is Entropy a Force of Nature?

Martin Johnson

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: dark energy
cosmic background radiation
dark ages
large-scale structure of the Universe

Online: 7 February 2024 (03:37:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0773.v1

Validation of HPV Knowledge Tool and Assessment of HPV Knowledge and Awareness among Students and Staff at IBB University, Niger State, Nigeria: Implications for Health Education and Prevention

Melvin Omone Ogbolu, Miklós Kozlovszky

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Cervical cancer; HPV knowledge; Awareness of HPV infection; Awareness of HPV vaccine; Scale validation; Quantile regression

Online: 10 January 2024 (10:01:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0137.v1

Observational Constraints and Future of the Universe with Dynamic Dark Energy

Florian Neukart

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Hubble tension; Cosmic Microwave Background; Large-scale structures; Dark energy constraints; Future cosmological observations

Online: 3 January 2024 (04:20:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0401.v1

Influence of Comorbidities on Chronic Obstructive Pulmonary Disease (COPD) Outcomes: Risk Prediction of Acute Exacerbations Using the Cumulative Illness Rating Scale (Cirs)

Domenico Di Raimondo, Edoardo Pirera, Chiara Pintus, Riccardo De Rosa, Martina Profita, Gaia Musiari, Gherardo Siscaro, Antonino Tuttolomondo

Subject: Biology And Life Sciences, Aging Keywords: Comorbidity; Multimorbidity; Chronic Obstructive Pulmonary Disease; COPD; Cumulative Illness Rating Scale; acute exacerbation of COPD (AECOPD)

Online: 7 November 2023 (10:33:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0299.v1

Using Ensemble Convolutional Neural Network to Detect Deepfakes Using Periocular Data

David Johnson, Xiaohonh Yuan, Kaushik Roy

Subject: Computer Science And Mathematics, Computer Science Keywords: deepfake detection; CNN; deep neural network; computer vision; scale invariant feature transform; histogram of oriented gradients

Online: 17 February 2023 (06:51:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0095.v1

Solar System-Like Systems with Special Reference to Relativistic Quantum Mechanics and Weak Gravitational Field

Peter Gara

Subject: Physical Sciences, Quantum Science And Technology Keywords: Solar system-like systems; Relativistic Quantum Mechanics; Weak Gravity; Proper Time Scale of the Solar System

Online: 4 November 2022 (13:42:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0277.v2

Research on Mechanical Braking Model of Cows Knee Joint

Meng Liu, Kexin Meng, Shuli Mei, Ruyi Xing

Subject: Physical Sciences, Mathematical Physics Keywords: Dairy cow; Lyapunov exponent; bio-mechanical model; Nonlinear dynamics; gait; Weight scale; Three-link model; Fractals

Online: 24 February 2022 (09:57:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0389.v1

Task-Adaptive Embedding Learning with Dynamic Kernel Fusion for Few-Shot Remote Sensing Scene Classification

Pei Zhang, Guoliang Fan, Chanyue Wu, Dong Wang, Ying Li

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: remote-sensing classification; scene classification; few-shot learning; meta-learning; vision transformers; multi-scale feature fusion

Online: 18 August 2021 (14:29:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0235.v1

Sensitivity of Stomate Size in Red Maple (Acer rubrum L.) Trees in Deciduous Forests to Urban Conditions

Covel R. McDermot, Vince D'Amico, Tara Trammell

Subject: Environmental And Earth Sciences, Environmental Science Keywords: abiotic stress; metro-scale; physiological acclimation; urban leaf morphology; red maple trees; stomate size; urban forests

Online: 15 April 2020 (09:32:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201903.0117.v1

An Accelerating and Rotating Planck-Hubble Universe (A Very Simple Model of Quantum Cosmology)

U. V. S. Seshavatharam, S. Lakshminarayana

Subject: Physical Sciences, Nuclear And High Energy Physics Keywords: planck scale; quantum cosmology; critical density; ordinary matter; dark matter; expansion velocity; angular velocity; Hubble’s law;

Online: 11 March 2019 (08:01:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints201901.0236.v1

Hybrid 3D Models: When Geomatics Innovations Meet Extensive Built Heritage Complexes

Filiberto Chiabrando, Giulia Sammartano, Antonia Spanò, Alessandra Spreafico

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: 3D models; multi-sensor; multi-scale; SLAM; MMS; LiDAR; UAV; data integration; data fusion; cultural heritage

Online: 23 January 2019 (10:08:42 CET)

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Preprint REVIEW | doi:10.20944/preprints201810.0329.v1

Modeling of Protein Structural Flexibility and Large-Scale Dynamics: Coarse-grained Simulations and Elastic Network Models

Sebastian Kmiecik, Maksim Kouza, Aleksandra Elzbieta Badaczewska-Dawid, Andrzej Kloczkowski, Andrzej Kolinski

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: protein dynamics; coarse-grained simulation; Monte-Carlo dynamics; structural flexibility; large-scale dynamics; elastic network model;

Online: 15 October 2018 (17:10:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0175.v1

Antineutrino Star Model of the Big Bang and Dark Energy

Tom F. Neiser

Subject: Physical Sciences, Particle And Field Physics Keywords: cosmology: theory; gravitation; early universe; dark energy; large-scale structure of universe; cosmic background radiation; neutrinos

Online: 12 June 2018 (08:43:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0258.v2

Revisiting the Derivation of Heisenberg's Uncertainty Principle: The Collapse of Uncertainty at the Planck Scale

Espen Haug

Subject: Physical Sciences, Thermodynamics Keywords: Heisenberg's uncertainty principle; certainty; wave function; Planck scale; Planck mass; Planck particle; Bell's Inequality; superposition; entropy; Compton clock

Online: 5 September 2018 (09:34:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1475.v1

Predictive Value of Serum VEGF Levels in Non-Small Cell Lung Cancer: A Review

Eleni Kokkotou, Andriani G. Charpidou, Nikolaos K. Syrigos

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Non-small cell lung cancer (NSCLC); Vascular endothelial growth factor (VEGF); VEGF receptors (VEGFRs); Angiogenesis; Biomarker; Tumor angiogenesis

Online: 19 September 2024 (11:16:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0456.v1

Design of Small-Type Permanent-Magnet Linear Motors and Drivers for Automation Application

Chia-Hsiang Ho, Jonq-Chin Hwang

Subject: Engineering, Electrical And Electronic Engineering Keywords: small-type permanent-magnet linear motor; end effects; cogging force; field-oriented control; S-curve motion trajectory control

Online: 5 September 2024 (11:12:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0189.v1

Sustainable Development of Small Business in Kazakhstan

Venera Zarubina, Mikhail Zarubin, Zhaukhar Yessenkulova, Tursyngul Gumarova, Almira Daulbayeva, Zhuldyz Meimankulova, Aizhan Kurmangalieva

Subject: Business, Economics And Management, Economics Keywords: small business; Kazakhstan; sustainable development; ESG; responsible investment; network interaction “ business entities – society – state”

Online: 3 September 2024 (10:36:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0886.v1

Musashi-1 Is a Novel Immunohistochemical Marker of Neuroendocrine Carcinoma of the Lung

Yu Izaki, Vishwa Jeet Amatya, Takahiro Kambara, Kei Kushitani, Yoshihiro Miyata, Morihito Okada, Yukio Takeshima

Subject: Public Health And Healthcare, Other Keywords: pathological diagnosis; Musashi-1; small cell carcinoma; large cell neuroendocrine carcinoma; lung cancer; surgical specimen; novel marker; immunohistochemistry

Online: 14 November 2023 (10:26:14 CET)

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Preprint REVIEW | doi:10.20944/preprints202309.1389.v1

Microgrids Overview and Performance Evaluation on Low-voltage Distribution Network

Ereola Johnson Aladesanmi, Kingsley Ogudo

Subject: Engineering, Electrical And Electronic Engineering Keywords: Keywords: Microgrid; small hydropower plant; wind farm; battery energy storage systems; grid-connected; stand-alone mode; power quality

Online: 20 September 2023 (13:59:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0122.v1

Overview on Therapeutic Options in Uncommon EGFR Mutant Non-Small Cell Lung Cancer (NSCLC): New Lights for an Unmet Medical Need

Giulia Pretelli, Calogera Claudia Spagnolo, Giuliana Ciappina, Mariacarmela Santarpia, Giulia Pasello

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Non-small cell lung cancer (NSCLC); EGFR; Tyrosine kinase inhibitors (TKIs); Uncommon mutation; Compound mutation; Intracranial activity; Immunotherapy

Online: 3 May 2023 (09:29:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0333.v1

Computational Insights into the Binding Mechanism of OxyS sRNA with Chaperone Protein Hfq

Mengxin Li, Yalong Cong, Yifei Qi, John Z.H. Zhang

Subject: Biology And Life Sciences, Biophysics Keywords: small RNA Oxys; RNA chaperone Hfq protein; gene expression regulator; molecular dynamics simulations; binding free energy; interaction entropy

Online: 20 September 2021 (12:47:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202108.0372.v1

NSCLC Biomarkers to Predict Response to Immunotherapy with Checkpoint Inhibitors (ICI): From the Cells to in-Vivo Images

Virginia Liberini, Annapaola Mariniello, Luisella Righi, Martina Capozza, Marco Donatello Delcuratolo, Enzo Terreno, Mohsen Farsad, Marco Volante, Silvia Novello, Désirèe Deandreis

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: immune checkpoint inhibitors; non-small cell lung carcinoma; PD-1; PD-L1; immune PET; immunotherapy; Radiomics; PET/CT

Online: 18 August 2021 (08:20:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0524.v1

Exosomal Hsp70 in Liquid Biopsies - A Biomarker for Prediction and Response Monitoring in Cancer

Caroline Werner, Stefan Stangl, Lukas Salvermoser, Melissa Schwab, Maxim Shevstov, Alexia Xanthopoulos, Fei Wang, Daniel Medenwald, Martin Windberg, Matthias Bache, Martin Schlapschy, Arne Skerra, Gabriele Multhoff

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Hsp70; sandwich ELISA; liquid biopsy; tumor biomarker; exosomes; prediction; response monitoring; non-small cell lung carcinoma (NSCLC); glioblastoma

Online: 21 May 2021 (15:06:37 CEST)

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In contrast to normal cells, tumor cells of multiple entities overexpress the Heat Shock Protein 70 (Hsp70) not only in the cytosol, but also present it on their plasma membrane in a tumor-specific manner. Furthermore, membrane-Hsp70 positive tumor cells actively release Hsp70 into lipid microvesicles termed exosomes into the blood. Due to conformational changes of Hsp70 in the lipid environment, most commercially available antibodies fail to detect membrane-bound and exosomal Hsp70. To fill this gap and to assess the role of exosomal Hsp70 in the circulation as a potential tumor biomarker, we established the novel complete Hsp70 (compHsp70) sandwich ELISA using two monoclonal antibodies (mAbs) that are able to recognize both, free and lipid-associated Hsp70 on the cell surface of viable tumor cells and exosomes. The epitopes of the mAbs cmHsp70.1 (aa 451-461) and cmHsp70.2 (aa 614-623) that are conserved among different species reside in the substrate-binding domain of Hsp70, with measured affinities of 0.42 nM and 0.44 nM, respectively. Validation of the compHsp70 ELISA revealed a high intra- and inter-assay precision, linearity in a concentration range of 1.56 to 25 ng/ml, high recovery rates of ‘spiked’ liposomal Hsp70 (>84%), comparable values between human serum and plasma samples, and no interference by food intake or age of the donors. Hsp70 concentrations in the circulation of patients with glioblastoma, squamous cell or adeno non-small cell lung carcinoma (NSCLC) at diagnosis were significantly higher than those of healthy volunteers. Hsp70 concentrations dropped concomitantly with the decrease in viable tumor mass on irradiation of patients with approximately 20 Gy (range 18 – 22.5 Gy) or after completion of radiotherapy (60 - 70 Gy). In summary, the compHsp70 ELISA presented herein provides a highly sensitive and reliable tool for measuring free and exosomal Hsp70 in liquid biopsies of tumor patients, levels of which can be used as a predictive tumor-specific biomarker, risk assessment and for monitoring therapeutic outcome.

Preprint ARTICLE | doi:10.20944/preprints202101.0227.v1

m5U54 tRNA Hypomodification by lack of TRMT2A Drives the Generation of tRNA-Derived Small RNAs

Marisa Pereira, Diana R. Ribeiro, Miguel M. Pinheiro, Margarida Ferreira, Stefanie Kellner, Ana R. Soares

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: tRNAs; tRNA-modifying enzyme; TRMT2A; methyltransferase; tRNA hypomethylation; tRNA-derived small RNAs; tRNA-derived stress-induced RNAs; angiogenin.

Online: 12 January 2021 (15:17:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0800.v1

From Barriers to Enablers: The Role of Organizational Learning in Transitioning SMEs into the Circular Economy

Sara Scipioni, Meir Russ, Federico Niccolini

Subject: Business, Economics And Management, Accounting And Taxation Keywords: organizational learning; circular economy; small and medium enterprises (SMEs); business model; supply chain; construction; Italy; Barrier and enabler

Online: 31 December 2020 (12:40:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202005.0077.v1

Knockdown of CENPF Inhibits the Progression of Lung Adenocarcinoma Mediated by ERβ2/5 Pathway

Hexiao Tang, Yuquan Bai, Lecai Xiong, Yanhong Wei, Weidong Hu, Ming Xu, Xuefeng Zhou, Gaofeng Pan, Li Zhang, Minglin Zhu, Zheng Tang, Zetian Yang, Xiao Zhou, Yi Cai, Michael Lanuti, Jinping Zhao

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: centromere protein F (CENPF); Estrogen Receptor beta; Lung Adenocarcinoma (LUAD); WGCNA package; non-small cell lung cancer (NSCLC)

Online: 5 May 2020 (12:08:59 CEST)

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Preprint REVIEW | doi:10.20944/preprints201711.0015.v1

Application of Virus-Derived Small Interfering RNAs (vsiRNAs) in Rice Viruses with Insect Vectors, Especially Rice Grassy Stunt Virus

Muhammad Arif, Saif Ul Islam, Muhammad Adnan, Muhammad Anwar, Zujian Wu

Subject: Biology And Life Sciences, Plant Sciences Keywords: RGSV; movement proteins; gene silencing; transgenic mechanism; virus-induced small interfering RNA; RNA silencing pathway; antiviral plant defenses

Online: 2 November 2017 (03:05:04 CET)

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Rice grassy stunt virus (RGSV) a member of Tenuivirus family, is very potent and destructive which effects rice crop in many countries, particularly China. Non coding RNAs have important functions in development and epigenetic regulation of gene expression in numerous organsisms. There is three type of small non coding RNAs have been found in eukaryotes, which are small interferring RNAs (siRNAs), microRNAs (miRNAs) and piwi interacting RNAs (piRNAs). Small RNAs (sRNAs) origination is from the infecting virus which is known as virus-derived small interfering RNAs (vsiRNAs), has responsibility for RNA silencing in plants. Virus-induced gene silencing (VIGS) is mainly dependent on RNA silencing (RNAi). Interestingly, RNA silencing happens in plants during viral infections. RNAi technique showed significant results in Nephotettix cincticeps. RNAi technique demonstrated the gene silencing of planthopper Nilaparvata lugens. The proteins P5, pcf4, Dnj, psn5, and pn6 act as potential movement proteins and serve as silencing suppressors for RGSV. VsiRNAs originate from dsRNA molecules which require Dicer-like (DCL) proteins, RNA dependent RNA polymerase (RdRP) proteins, and Argonaute (AGO) proteins. RdRP uses ssRNA for perfect RNA amplification process and can also be used for DCL dependent secondary vsiRNA formation. VSRs interfere with the movement of signals during silencing mechanism. Moreover, intercellular movement of viruses is facilitated by virus-encoded movement protein. RNAi is found in many eukaryotes which are related to transcriptional or post-transcriptional regulation by gene suppression. Transcription is bidirectional in ssDNA viruses which are originated from dsRNA molecules. In this review, we highlighted the biology of Rice grassy stunt virus and its insect vector and its silencing suppressors. This work will be helpful for plant virologists to understand the whole biogenesis mechanism for rice viruses especially RGSV.

Preprint ARTICLE | doi:10.20944/preprints202307.1051.v9

Energy Renormalization in a Berry Geometrical Phase: Low-Energy Perturbations of the Strong Interaction and the QCD Mass Gap

Mark Gibbons

Subject: Physical Sciences, Particle And Field Physics Keywords: Berry geometrical phase; dual superconductivity; scale- and gauge-invariance; hyperbolic curvature; strong gravity; renormalization; QCD mass gap

Online: 18 April 2024 (14:04:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0464.v1

Efficient Large-Scale Urban Parking Prediction: Graph Coarsening Based on Real-Time Parking Service Capability

Yixuan Wang, Zhenwu Chen, Kangshuai Zhang, Yunduan Cui, Lei Peng

Subject: Engineering, Transportation Science And Technology Keywords: Large-scale urban parking prediction; Real-time parking service capacity; Graph coarsening; Temporal convolutional autoencoder; Graph attention

Online: 5 September 2024 (12:07:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0717.v1

A Novel Five-Surface Phosphor-in-Glass for High Illumination and Excellent Color Uniformity in Larger Scale LEDs

Hong-Wei Huang, Chien-Wei Huang, Yi-Chian Chen, Hsing-Kun Shih, Wei-Chih Cheng, Chun-Nien Liu, Chia-Chin Chiang

Subject: Engineering, Electrical And Electronic Engineering Keywords: Five-surface phosphor layer; phosphor-in-glass; laser engraving process; chip scale package; white light-emitting diode.

Online: 9 July 2024 (08:42:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0694.v1

Spatial Distribution Characteristics of Urban Air Quality and the Spatial Heterogeneity of Driving Factors: A Case Study of Beijing

Zhixiong Tan, Haili Wu, Qingyang Chen, Jiejun Huang

Subject: Environmental And Earth Sciences, Pollution Keywords: air quality index; multi-scale geographically weighted regression; multi-source geographic data; spatial autocorrelation analysis; spatial heterogeneity

Online: 11 June 2024 (09:39:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1657.v1

Upscaling and Risk Evaluation of the Synthesis of the 3-5-Diamino-1H-Pyrazole, Disperazol

Charlotte Uldahl Jansen, Katja Egeskov Grier, Jens Bo Andersen, Louise Dahl Hultqvist, Martin Nilsson, Claus Moser, Michael Graz, Tim Tolker-Nielsen, Michael Givskov, Katrine Qvortrup

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: biofilm; dispersal; pyrazole; c-di-GMP; large scale synthesis; flow chemistry; safety; dust analysis; Pseudomonas aeruginosa; preclinical

Online: 27 May 2024 (09:46:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0241.v1

Indirect Model Predictive Control on Epidemiological Stochastic Blockmodels

Jonas Hjulstad, Morten Hovd

Subject: Engineering, Control And Systems Engineering Keywords: identification for control; optimization and control of large-scale network systems; Monte Carlo methods; high performance computing

Online: 6 May 2024 (07:49:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1842.v1

A Novel Five-Surface Phosphor-in-Ceramic for High Illumination and Excellent Color Uniformity in Larger Scale LEDs

Hong-Wei Huang, Chien-Wei Huang, Yi-Chian Chen, Hsing-Kun Shih, Wei-Chih Cheng, Chun-Nien Liu, Chia-Chin Chiang, Wood-Hi Cheng

Subject: Engineering, Electrical And Electronic Engineering Keywords: five-surface phosphor layer; phosphor-in-ceramic; laser engraving process; chip scale package; white light-emitting diode

Online: 28 April 2024 (10:17:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1385.v1

Land Management Scale and Carbon Balance Ratio: Spatial Spillover Effects and Threshold Characteristics

Wenjin Wu, Yaping Chen, Yule Gu, Anqi Guo, Hao Wang, Jun Guan

Subject: Business, Economics And Management, Economics Keywords: land management scale; net carbon effect; carbon balance ratio; net carbon sink; spatial spillover effect; threshold characteristics

Online: 22 April 2024 (10:16:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1812.v1

Scale Invariant Parity Doublet Model: Interplay between the Vector Mesons and the Dilatons /Parity Doubling in Dense Baryonic Matter as an Emergent Symmetry and Pseudo-Conformal Model

Hyun Kyu Lee

Subject: Physical Sciences, Nuclear And High Energy Physics Keywords: scale invariance; parity doubling; pseudo-conformal phase; vector meson-dilaton interplay; compact star matter; speed of sound

Online: 29 March 2024 (09:57:46 CET)

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The star matter composed of nucleons deep inside the compact star like a neutron star is believed to be very dense and various new types of concepts and physical phenomena due to the nontrivial strong correlations are naturally expected. Peudo-conformality in dense star matter has been discussed recently assuming the hidden underlying scale symmetry, which is partly supported by the recent discussions of infrared conformal window of QCD. It is found that the appearance of dilaton and the dilatonic mean field calculation of nucleonic matter lead to the density independent nucleon mass at higher density regime than normal nuclear matter density. Non-vanishing constant nucleon mass can be considered as a chiral invariant mass of the parity doublet model, in which the chiral symmetry is manifested even in the massive nucleon sector provided with a parity doubling. In this paper we will discuss how the chiral and scale symmetry are correlated to lead the parity doublet symmetry inside the core of the compact star. A simple schematic model is adopted. The star matter at T=0 is basically composed of the nucleons. As a first approximation, they can be treated as free fermions with the effective mass filled up to fermi surface. There is a nontrivial feature due to the interplay between vector meson and nucleon(or equivalently dilaton, χ). The trace of energy momentum tensor approaches density independent, the pseudo-conformal phase. Local fluctuations inside the star matter will be travelling with the speed of sound which depends on the equation of state. In the pseudo-conformal phase, the speed of sound approaches to the conformal velocity for the scale symmetric matter, vc=13c. The excitations of the parity doublets in the compact star matter as an emerging phenomena in pseudo-conformal phase will be discussed in connection to the chiral symmetry. The possible implication on the corespondence of hadrons to quark degrees of freedom will be briefly discussed.

Preprint REVIEW | doi:10.20944/preprints202401.0789.v1

Microbiome Modeling: A Beginner’s Guide

Emanuel Lange, Lena Kranert, Jacob Krüger, Dirk Benndorf, Robert Heyer

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: systems microbiology; microbial ecology; omics data integration; metaproteomics; genome-scale modeling; constraint-based modeling; boolean modeling, bioinformatics

Online: 10 January 2024 (09:57:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0642.v1

PointBLIP: Zero-Training Point Cloud Classification Network Based on BLIP-2 Model

Yunzhe Xiao, Yong Dou, Shaowu Yang

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: point cloud classification; zero-training; large-scale vision-and-language model; zero-shot classification; few-shot classification

Online: 8 January 2024 (17:03:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.2201.v1

Radargrammetric 3D Imaging through Composite Registration Method Using Multi-Aspect SAR Imagery

Yangao Luo, Yunkai Deng, Wei Xiang, Heng Zhang, Congrui Yang, Longxiang Wang

Subject: Engineering, Electrical And Electronic Engineering Keywords: radargrammetry; synthetic aperture radar (SAR); multi-aspect SAR imagery; SAR image registration; scale invariant feature transform (SIFT)

Online: 28 December 2023 (14:55:26 CET)

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Interferometric synthetic aperture radar (InSAR) and tomographic SAR measurement techniques are commonly used for the three-dimensional (3D) reconstruction of complex areas, while the effectiveness of these methods relies on the interferometric coherence among SAR images with minimal angular disparities. Radargrammetry exploits stereo image matching to determine the spatial coordinates of corresponding points in two SAR images, and acquire their 3D properties. The performance of the image matching process directly impacts the quality of the resulting digital surface model (DSM). However, the presence of speckle noise, along with dissimilar geometric and radiometric distortions, poses considerable challenges to achieve accurate stereo SAR image matching. To address the aforementioned challenges, this paper proposes a radargrammetric method based on composite registration of multi-aspect SAR images. The proposed method combines coarse registration using scale invariant feature transform (SIFT) with precise registration using normalized cross-correlation (NCC) to achieve accurate registration between multi-aspect SAR images with large disparities. Furthermore, the multi-aspect 3D point clouds are merged by the proposed radargrammetric 3D imaging method, resulting in 3D imaging of target scenes based on multi-aspect SAR images. For validation purpose, this paper presents a comprehensive 3D reconstruction of the Five-hundred-meter Aperture Spherical radio Telescope (FAST) by using Ka-band airborne SAR images. It does not necessitate prior knowledge of the target and is applicable to the detailed 3D imaging of large-scale areas with complex structures. In comparison to other SAR 3D imaging techniques, it reduces the requirements for orbit control and radar system parameters. To sum up, the proposed 3D imaging method with composite registration guarantees imaging efficiency while enhances the imaging accuracy of crucial areas with limited data.

Preprint ARTICLE | doi:10.20944/preprints202302.0412.v1

An Adaptive Layered Clustering Framework with Improved Genetic Algorithm for Solving Large-Scale Traveling Salesman Problems

Hai-yang Xu, Heng-You Lan

Subject: Computer Science And Mathematics, Information Systems Keywords: Computational complexity analysis; High parallelizability; Improved genetic algorithm; Adaptive layered clustering framework; Large-scale traveling salesman problem

Online: 24 February 2023 (01:20:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202209.0017.v1

Application of Reichardt’s Solvent Polarity Scale [E_T(30)] in the Selection of Bonding Agents for Composite Solid Rocket Propellants

Franco Cataldo

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: Bonding agents (BA); composite solid rocket propellants (CSRP); Reichardt’s ET(30) polarity scale; mechanical properties of CSRP.

Online: 1 September 2022 (09:25:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0141.v2

Effectiveness of Health Education Given To Prevent Back Pain In Women: Pre- And Post-Test Study

Elizabeth Olubunmi Babalola

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: low back pain; women; exercise; physical activity; health education; Oswestry Disability Index; Back Pain Functional Scale; ergonomics

Online: 10 May 2021 (14:07:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0292.v1

HIV Propagation in a Population Group Considering Infection in the Immune System Of Each Infected Individual

Sol de Amor Vásquez-Quintero, Hernán Darío Toro-Zapata, Dennis Alexánder Prieto-Medellín

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Multi-scale model; system of differential equations; HIV propagation; complex network; basic reproduction number; antiretroviral therapy; prevalence.

Online: 12 April 2021 (12:35:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0400.v1

What is the Real Shape of the Hubble Diagram, z = H₀*D or z+1= e^H0*t? Analysis of the SN1a Supernovae and Gamma Ray Burst Redshift/Magnitude Data including the High Redshift Range up to z = 8.1

Laszlo Marosi

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: galaxies; distances and redshift; high redshift; stars; Gamma ray bursts; individual; supernovae; individual; cosmology; distance scale; observations

Online: 24 May 2020 (19:07:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0272.v1

Assessing Cognitive and Social Attitudes Toward Environmental Conservation in Coral Reef Social-Ecological Systems

Kostas Alexandridis

Subject: Social Sciences, Cognitive Science Keywords: environmental attitudes; social-ecological systems; coral reef; scale development; item-response theory; reliability; generalized structural equation model

Online: 18 June 2018 (15:26:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0111.v1

Exposure to Environmental Tobacco Smoke and Effects on Physical and Mental Health of Slovak School Children

Ludmila Sevcikova, Jana Babjakova, Jana Jurkovicova, Martin Samohyl, Zuzana Stefanikova, Erika Machacova, Diana Vondrova, Etela Janekova, Katarina Hirosova, Alexandra Filova, Michael Weitzman, Lubica Argalasova

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Environmental Tobacco Smoke (ETS); Slovak school children; mental health; physical health; Columbia Impairment Scale; Behavioral Problem Index

Online: 7 May 2018 (09:23:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints201710.0046.v1

Full-Scale/Model Test Comparisons to Validate the Traditional ABL Wind Tunnel Simulation Technique: A Literature Review

X.X. Cheng, J. Dong, Y. Peng, L. Zhao, Y.J. Ge

Subject: Engineering, Civil Engineering Keywords: comparative study; full-scale measurement; wind tunnel model test; multiple-fan actively controlled wind tunnel; research scheme

Online: 9 October 2017 (06:38:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201709.0098.v2

A Conversion Method to Determine Regional Vegetation Cover Factor from Standard Plots based on Large Sample Theory and TM Images: A Case Study in the Eastern Farming-pasture Ecotone of Northern China

Degen Lin, Yuan Gao, Yaoyao Wu, Peijun Shi, Huiming Yang, Jing’ai Wang

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: farming-pasture ecotone; TM image; remote sensing; vegetation cover factor; scale conversion; land use; high resolution image

Online: 21 September 2017 (16:33:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.1120.v1

Twelve-Months Outcomes and Optical Coherence Tomography (OCT) Biomarkers After Intravitreal Dexamethasone Implant in Pseudophakic Eyes with Post-Vitrectomy Cystoid Macular Edema (CME), Refractory to Medical Therapy

Francesco Pignatelli, Alfredo Niro, Giuseppe Addabbo, Pasquale Viggiano, Giacomo Boscia, Maria Oliva Grassi, Francesco Boscia, Cristiana Iaculli, Giulia Maria Emilia Clima, Antonio Barone, Ermete Giancipoli

Subject: Medicine And Pharmacology, Ophthalmology Keywords: Postsurgical cystoid macular edema; small-gauge pars plana vitrectomy; dexamethasone intravitreal implant; OCT biomarkers; rhegmatogenous retinal detachment; epiretinal membrane

Online: 15 October 2024 (06:27:31 CEST)

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Background: To evaluate the incidence of postsurgical cystoid macular edema (PCME) after small-gauge pars plana vitrectomy (PPV) for different retinal pathologies and to assess the role of optical coherence tomography (OCT) biomarkers to guide treatment decision in patients with PCME, refractory to medical therapy. Materials and Methods: Medical records of consecutive pseudophakic patients, who underwent PPV for different retinal pathologies, were retrospectively evaluated in this single center, uncontrolled study. The incidence of post-PPV CME was assessed in this population. Eyes that presented with post-PPV CME within the first 2 months after surgery were considered for further evaluation. A minimum follow-up of 12 months, history of previous cataract surgery performed not earlier than 1 year before PPV, the availability of full clinical and OCT data at 1, 3, 6, 9 and 12 months after PPV, constituted the minimal requirements to be included in the 12-months assessment. Mean best corrected visual acuity (BCVA; LogMAR) together with mean central macula thickness (CMT; m) change, and response to different treatments (medical therapy and dexamethasone intravitreal implant) were evaluated. The impact of specific clinical and structural OCT biomarkers on the exposure to dexamethasone (DEX) intravitreal treatment was assessed. Eventual ocular and non-ocular adverse events, potentially related to the treatment, were investigated as-well. Results: Of 346 pseudophakic patients (352 eyes) enrolled in the study, 54 (54 eyes) developed CME within the first 2 months after PPV (incidence of 15.3%). After the exclusion of 6 subjects, the remaining 48 pa-tients were dimed eligible for the 12-months analysis. Preoperative mean BCVA (1.44 ± 0.99 LogMAR) sig-nificantly improved to 0.32 ± 0.37 LogMAR at 12 months (P< 0.001). Mean baseline CMT of 347 (± 123.5) m, significantly decreased to 290 m (± 80.4; P=0.003) by the end of the FU. Twenty-five eyes (52%) re-quired one or more DEX intravitreal implants for CME, refractory to topical therapy. The correlation analy-sis disclosed the existence of significant correlations between mean CMT values at different time points of the FU. Additionally, patients who required intravitreal therapy at months 3 and 9, were more likely to present with the following features at 1 month OCT: intraretinal fluid (IRF), disorganization of inner retinal layers (DRIL), disorganization of outer retinal layers (DROL) and hyperreflective foci (HRF). No major safe-ty issues arose. Conclusion: Topical therapy alone can be a valuable option for post-PPV CME in approximatively 50% of pa-tients. Significant visual acuity recovery and CMT reduction at 12 months, demonstrated DEX intravitreal implant can be a safe and effective second-line treatment for pseudophakic patients with post-PPV CME, refractory to medical therapy. The presence of specific OCT biomarkers may indicate a more severe CME that might benefit from the intravitreal therapy.

Preprint REVIEW | doi:10.20944/preprints202409.1996.v1

Strategic Innovation in HRIS and AI for Enhancing Workforce Productivity in SMEs: A Systematic Review

Tshepho T.N Mohlala, Luyanda L.M Mehlwana, Uripfe P. Nekhavhambe, Bonginkosi Thango, Lerato Matshaka

Subject: Business, Economics And Management, Business And Management Keywords: human resources information system (HRIS); small and medium-sized enterprises (SMEs); workforce productivity; impact; compliance; systematic review

Online: 25 September 2024 (11:53:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.0259.v1

Paying Homage to Microvessel Remodeling and Small Vessel Disease in Neurodegeneration: Implications for the Development of Late-Onset Alzheimer’s Disease

Melvin Ray Hayden

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Brain endothelial cells; Blood-brain barrier; Dementia; Late-onset Alzheimer's disease; Microvessel remodeling; Neurodegeneration; Neurovascular unit; Small vessel disease

Online: 3 September 2024 (16:58:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0128.v1

Towards Hydraulic Design Optimization of Shaft Hydropower Plants: A 3D-CFD Application Based on Physical Models

Bertalan Alapfy, Nicolas Francisco Gamarra, Nils Rüther

Subject: Engineering, Civil Engineering Keywords: small hydropower; sustainable hydropower; hydraulic engineering; computational fluid dynamics; CFD; numerical modeling; porous media; trash rack; intake; hydraulic design

Online: 2 September 2024 (17:02:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0487.v1

Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratio: Side by Side with Molecular Mutations in Patients with Non-small Cell Lung Cancer. The INOLUNG Study

Corina Eugenia Budin, Iuliu Gabriel Cocuz, Liviu Sorin Enache, Ionuț Alexandru Rența, Cristian Cazacu, Dariana Elena Pătrîntașu, Mihai Olteanu, Ruxandra-Mioara Râjnoveanu, Edith Simona Ianoși, Armand Râjnoveanu, Ovidiu Simion Cotoi

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Neutrophil to lymphocyte ratio (NLR); Platelets to lymphocite ratio (PLR); Non Small Cell Lung Cancer (NSCLC); molecular mutations; EGFR

Online: 6 July 2024 (03:29:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.0753.v1

Predictive Quality Analytics of Surface Roughness in Turning Operation Using Polynomial and Artificial Neural Network Models

Peter Bober, Kristína Zgodavová, Miroslav Čička, Mária Mihaliková

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: fine turning, AISI 304; round bar; roughness; food processing equipment; machine learning; predictive quality; small batch; artificial neural network

Online: 12 December 2023 (06:26:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1943.v1

Epigenetic Signatures of In Vitro and In Vivo Experimental Models Employed in Non-small Cell Lung Cancer and the Unique miR-148b-3p/PVT1/ZBTB7A Regulatory Network Discriminating Large Cell Lung Carcinoma

Magda Spella, Eleftherios Bochalis, Katerina Athanasopoulou, Argyri Chroni, Irene Dereki, Giannoula Ntaliarda, Ifigeneia Makariti, Georgios Psarias, Caterina Constantinou, Vasiliki Chondrou, Argyro Sgourou

Subject: Biology And Life Sciences, Life Sciences Keywords: Non-small cell lung cancer; epigenetic deregulation; micro-RNAs; long non-coding RNAs; epigenetically motivated transcription factors; epigenetic networks

Online: 30 October 2023 (14:00:39 CET)

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