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Preprint REVIEW | doi:10.20944/preprints202407.1134.v1

The Evil Twins of Chronic Pelvic Pain Syndrome: a systematic review and meta-analysis on Interstitial Cystitis/Bladder Pain Syndrome and Endometriosis

Inzoli Alessandra, Barba Marta, Carazita Valeria, Cola Alice, Fantauzzi Martina, Passoni Paolo, Polizzi Serena, Frigerio Matteo

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: endometriosis; chronic pelvic pain; interstitial cystitis / bladder pain syndrome

Online: 15 July 2024 (08:11:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0401.v1

Influence of Comorbidities on Chronic Obstructive Pulmonary Disease (COPD) Outcomes: Risk Prediction of Acute Exacerbations Using the Cumulative Illness Rating Scale (Cirs)

Domenico Di Raimondo, Edoardo Pirera, Chiara Pintus, Riccardo De Rosa, Martina Profita, Gaia Musiari, Gherardo Siscaro, Antonino Tuttolomondo

Subject: Biology And Life Sciences, Aging Keywords: Comorbidity; Multimorbidity; Chronic Obstructive Pulmonary Disease; COPD; Cumulative Illness Rating Scale; acute exacerbation of COPD (AECOPD)

Online: 7 November 2023 (10:33:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0981.v1

Sarcosine May Induce EGF Production or Inhibit the Decline in EGF Concentrations in Patients with Chronic Schizophrenia (Results of the PULSAR Study)

Agnieszka Pawlak, Bartosz Kaczmarek, Adam Wysokiński, Dominik Strzelecki

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: EGF; sarcosine; schizophrenia; negative symptoms

Online: 14 August 2023 (04:47:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0796.v1

Effects of Early General Anesthetic Exposure on Susceptibility to Chronic Pain by Enhancement of Neural Activity via Mammalian Target of Rapamycin Pathway

Qun Li, Reilley Paige Mathena, Fengying Li, Xinzhong Dong, Yun Guan, Cyrus David Mintz

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: anesthesia neurotoxicity; neuropathic pain; neural activity; mammalian target of rapamycin (mTOR); dorsal spinal cord (DSC), dorsal root ganglion (DRG).

Online: 10 August 2023 (08:17:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.2226.v1

Red Blood Cells and Endothelium Derived Circulating Extracellular Vesicles in Health and Chronic Heart Failure: A Focus on Phosphatidylserine Dynamics in Vesiculation

Rosa Suades, Alba Vilella-Figuerola, Teresa Padró, Sonia Mirabet, Lina Badimon

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: annexin V; connexin 43; endothelial cells; extracellular vesicles; heart failure; leukocytes; microvesicles; phosphatidylserine; platelets; red blood cells

Online: 30 June 2023 (10:49:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1449.v1

Promoting self-management and independent living of elders with chronic diseases through technology: A study of self-reported needs, priorities, and preferences.

Argyroula Kalaitzaki, Michael Rovithis, Alexios Dimitropoulos, Sofia Koukouli, Manolis Linardakis, Elli Katsiri, Nikos Rikos, George Vasilopoulos, George Tsolas, Aikaterini Papachristou, Anastasia Dimitrantzou, Dimitrios Katsiris, Areti Stavropoulou

Subject: Public Health And Healthcare, Other Keywords: chronic non-communicable diseases; disease management; digital health technologies; technology-based applications; mHealth; mobile apps

Online: 20 June 2023 (14:25:24 CEST)

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Background and Objectives: Elders’ needs are rarely examined beforehand, and thus, although technology-based tools can enhance self-management, acceptability rates are still low. This study aimed to examine and compare self-reported needs, priorities, and preferences of elders with heart failure (HF), diabetes mellitus (DM), and chronic obstructive pulmonary disease (COPD) toward technology use to enhance self-management. Materials and Methods: A convenience sample of 473 participants over 60s (60.5% females), diagnosed with HF (N=156), DM (N=164), or COPD (N=153) was recruited. They were administered a questionnaire about the usefulness of technology in general and in specific areas of disease management. Results: Most participants (84.7%) admitted that technology is needed for better disease management. This was equally recognized across the three groups both for the overall and specific areas of disease management (in order of priority: ‘Information’, ‘Communication with Physicians & Caregivers’, and ‘Quality of Life & Wellbeing’). Sociodemographic differences were found. Cell phones and PCs were the devices of preference. The four common features prioritized by all three groups were related to ‘information about disease management’ (i.e., monitoring symptoms, reminders for medication intake, management and prevention of complications), whereas the fifth one was related to ‘communication with physicians and caregivers (i.e., in case of abnormal or critical signs). The top disease-specific feature was also monitoring systems (of respiratory rate or blood sugar or blood pressure, oxygen), whereas other disease-specific features followed (i.e., maintaining normal weight for HF patients, adjusting insulin dose for DM patients, and training on breathing exercises for COPD patients). Conclusions: Elders in these three samples seem receptive to technology in disease management. mHealth tools, incorporating both common and disease-specific features and addressing different chronic patients, and being personalized at the same time, could be cost-saving and useful adjuncts in routine clinical care to improve self-management.

Preprint ARTICLE | doi:10.20944/preprints202305.2023.v1

Inhaled Corticosteroids and the Risk of Nontuberculous Mycobacterial Pulmonary Disease in Chronic Obstructive Pulmonary Disease: Findings from a Nationwide Population-Based Study

Iseul Yu, Se Hwa Hong, Min-Seok Chang, Seok Jeong Lee, Suk Joong Yong, Won-Yeon Lee, Sang-Ha Kim, Ji-Ho Lee

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: nontuberculous mycobacterial pulmonary disease; inhaled corticosteroid; chronic obstructive pulmonary disease; fluticasone; budesonide

Online: 30 May 2023 (02:34:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1063.v1

Empagliflozin Attenuates Vascular Calcification in Mice with Chronic Kidney Disease by Regulating the NFR2/HO-1 Anti-Inflammatory Pathway through AMPK Activation

Chia-Wen Lu, Chung-Jen Lee, Yi-Jen Hsieh, Bang-Gee Hsu

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: empagliflozin; vascular calcification; AMP-activated protein kinase; nuclear factor erythroid-2-related factor; heme oxygenase 1; chronic kidney disease

Online: 27 April 2023 (09:35:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0745.v1

Is Thoracic Kyphosis Relevant to Pain, Autonomic Nervous System Function, Disability, and Cervical Sensorimotor Control in Patients with Chronic Nonspecific Neck Pain?

Ibrahim Moustafa Moustafa, Tamer Mohamed Shousha, Ashokan Arumugam, Deed E. Harrison

Subject: Medicine And Pharmacology, Other Keywords: Thoracic spine; Neck pain; Kyphosis; Sensorimotor control; Posture

Online: 23 April 2023 (03:35:29 CEST)

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There is great interest in thoracic kyphosis as it is thought to be a contributor to neck pain, neck disability, and sensorimotor control measures; though this has not been completely inves-tigated in treatment or case control studies. This case control design investigated participants with non-specific chronic neck pain. Eighty participants with a defined hyper-kyphosis (> 55°) were compared to 80 matched participants with normal thoracic kyphosis (< 55°). Participants were matched for age and neck pain duration. Hyper-kyphosis was further categorized into two distinct types: postural kyphosis (PK) and Scheuermann’s kyphosis (SK). Posture measures included formetric thoracic kyphosis and the craniovertebral angle (CVA) to assess forward head posture. Sensorimotor control was assessed by the following measures: smooth pursuit neck torsion test (SPNT), overall stability index (OSI) and left and right rotation repositioning accuracy. A measure of autonomic nervous system function included the amplitude and latency of skin sympathetic response (SSR). Differences in variable measures were examined using the Student’s t-test to compare the means of continuous variables between the two groups. Pearson correlation was used to evaluate the relationship between participant’s thoracic kyphosis magnitude (in each group separately and as an entire population) and their CVA, SPNT, OSI, head repositioning ac-curacy, and SSR latency and amplitude. Hyper-kyphosis participants had a significantly greater neck disability index compared to the normal kyphosis group (p < 0.001) with the SK group having greatest disability (p < 0.001). Statistically significant differences between the two kyphosis groups and the normal kyphosis group for all the sensorimotor measured variables were identified with the SK group having the most decreased efficiency of the measures in the hyper-kyphosis group, including: SPNT, OSI and left and right rotation repositioning accuracy. Also, there was a signif-icant difference in neurophysiological findings for SSR amplitude (entire sample of kyphosis vs. normal kyphosis, p < 0.001), but there was no significant difference for SSR latency (p = .07). The CVA was significantly greater in the hyper-kyphosis group (p < 0.001). The magnitude of the thoracic kyphosis correlated with worsening CVA (with the SK group having the smallest CVA; p < 0.001) and the magnitude of the decreased efficiency of the sensorimotor control measures and the amplitude and latency of the SSR. The PK group, overall, showed the greatest correlations between thoracic kyphosis and measured variables. Participants with hyper-thoracic kyphosis exhibited abnormal sensorimotor control and autonomic nervous system dysfunction compared to those with normal thoracic kyphosis.

Preprint ARTICLE | doi:10.20944/preprints202210.0437.v1

Differential Effects of Chronic Methamphetamine Treatment on High-Frequency Oscillations and Responses to Acute Methamphetamine and NMDA Receptor Blockade in Conscious Mice

Matthew Hudson, Joshua Foreman, Gil Rind, Elizabeth Manning, Nigel Jones, Maarten Van den Buuse

Subject: Social Sciences, Behavior Sciences Keywords: methamphetamine; mice; neural oscillations; gamma power; sensitisation

Online: 28 October 2022 (02:34:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0234.v1

Effect of Melatonin Plus Zinc Supplementation on Fatigue Perception in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial

Jesus Castro-Marrero, Maria-Cleofé Zaragozá, Irene López-Vílchez, José Luis Galmés, Joan Carles Domingo, Sara Maurel, José Alegre-Martin

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: chronic fatigue syndrome; fatigue; myalgic encephalomyelitis; melatonin; quality of life; sleep quality; zinc

Online: 8 March 2021 (16:00:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202003.0432.v1

Chronic Fatigue Syndrome and Fibromyalgia-Like Symptoms Are an Integral Component of the Phenome of Schizophrenia: Neuro-Immune and Opioid System Correlates

Rana Fadhil Mousa, Hussein Kadhem Al-Hakeim, Amir Alhaidari, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: chronic fatigue syndrome; myalgic encephalomyelitis; schizophrenia; neuroimmunomodulation; inflammation; biomarkers

Online: 29 March 2020 (10:52:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints201909.0188.v1

How Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) Progresses: A Framework for Research and the Prevention, Treatment, and Rehabilitation in ME/CFS

Luis Nacul, Shennae O'Boyle, Flavio E. Nacul, Kathleen Mudie, Caroline C. Kingdon, Jacqueline M. Cliff, Taane G. Clark, Hazel M. Dockrell, Eliana M. Lacerda

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Chronic Fatigue Syndrome; Chronic Illness; ME/CFS; Management; Research

Online: 17 September 2019 (12:38:57 CEST)

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We propose a framework for the understanding of the pathophysiology and management of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) that considers wider determinants of health and long-term temporal variation in pathophysiological features and disease phenotype throughout the natural history of the disease. As in other chronic diseases, ME/CFS evolves through different stages, from asymptomatic predisposition, progressing to a prodromal stage, and then to symptomatic disease. Disease incidence depends on genetic makeup and environment factors, the exposure to an insult, or repeated insults, and the nature of the host response. In people who develop ME/CFS, normal homeostatic processes in response to adverse insults may be replaced by aberrant responses leading to dysfunctional states. Thus, the predominantly neuro-immune and autonomic manifestations, underlined by a hyper-metabolic state, that characterise early disease, may be followed by various processes leading to multi-systemic related symptoms. This abnormal metabolic state and the effects of a range of mediators such as products of oxidative and nitrosamine stress, may lead to progressive cell and metabolic dysfunction culminating in a hypometabolic state with low energy production. These processes do not seem to happen uniformly; although a spiralling of progressive inter-related and self-sustaining abnormalities may ensue, reversion to states of milder abnormalities is possible if the host is able to restate responses to improve homeostatic equilibrium. Disease management and research efforts should seek to identify and apply strategies targeted at the different pathophysiological dysfunctions that characterise different disease stages. As disease presentation varies over time, no single case description, set of diagnostic criteria, or molecular feature is currently diagnostic for all patients at all times. While acknowledging its limitations due to the incomplete research evidence, we suggest the proposed framework may improve research design and health care interventions for people with ME/CFS.

Preprint COMMUNICATION | doi:10.20944/preprints201902.0134.v1

Impact of Polypharmacy on Candidate Biomarker miRNomes for the Diagnosis of Fibromyalgia and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Striking back on Treatments

Eloy Almenar-Pérez, Teresa Sánchez-Fito, Tamara Ovejero, Lubov Nathanson, Elisa Oltra

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Fibromyalgia (FM); Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS); microRNA; miRNome; pharmacogenomics; pharmacoepigenomics; SM2miR; Pharmaco-miR; repoDB; ME/CFS Common Data Elements (CDEs)

Online: 14 February 2019 (11:04:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.2264.v1

Dietary Omega-3 PUFA Intake in Patients with Chronic Kidney Disease: The Association with Vitamin D Deficiency, Intima-Media Thickness and Blood Pressure

Danijela Ristic-Medic, Marija Takic, Biljana Pokimica, Brankica Terzic, Milica Kojadinovic, Toplica Lepic, Slavica Radjen, Vesna Vucic

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: omega-3; carotid intima-media thickness; chronic kidney disease; cardiovascular risk; hemodialysis

Online: 30 August 2024 (15:32:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.2101.v1

Circulating Cell-Free Nuclear DNAs Predicted an Improvement of Systolic Left Ventricular Function in Individuals with Chronic Heart Failure with Reduced Ejection Fraction

Tetiana Berezina, Oleksandr O. Berezin, Michael Lichtenauer, Alexander E Berezin

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: heart failure with improved ejection fraction; heart failure with reduced ejection fraction; cell-free nuclear DNA; biomarkers

Online: 29 August 2024 (06:08:42 CEST)

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Patients with heart failure (HF) with improved LVEF (HFimpEF) demonstrate better clinical outcomes when compared with individuals without restoration of cardiac function. Identification of predictors for HFimpEF may play a crucial role in individual management of HF with reduced EF (HFrEF). Cell-free nuclear (cf-nDNA) DNA are released from damaged cells and contribute to adverse cardiac remodeling, cardiac dysfunction and inflammation. The purpose of the study was to elucidate whether cf-nDNAs are associated with HFimpEF. It has been prescreened 1416 patients with HF using local database. Between October 2021 and August 2022 we included 452 patients chronic HFrEF after prescription of optimal guideline-based therapy and identified HFimpEF in 177 individuals from them according to the criteria of European Society of Cardiology. Measurements of circulating biomarkers were performed at baseline and in 6 months. Detection of cf-nDNA was executed with real time quantitative PCR (qPCR) using NADH dehydrogenase, ND2 and beta-2-microglobulin. We found that HFimpEF was associated with a significant decrease in the levels of cf-nDNA when compared with the patients from persistent HFrEF cohort. Presence of ischemia-induced cardiomyopathy (odds ration [OR] = 0.75; confidence interval [CI] = 0.62 – 0.88; p = 0.044), type 2 diabetes mellitus (OR = 0.77; CI = 0.71 – 0.82; p = 0.042) and digoxin administration (OR = 0.85; CI = 0.72-0.97; p = 0.042) were negative factors for HFimpEF, whereas NT-proBNP ≤1940 pmol/mL (OR = 1.42; 95% CI = 1.19-1.98, p = 0.001), relative decrease in NT-proBNP levels (>35% vs. ≤35%) from baseline (OR = 1.52; 95% CI = 1.38-0.69, p = 0.001) and cf-nDNA ≤7.5 μmol/L (OR = 1.56; 95% CI = 1.07-2.94, p = 0.001) were positive predictors for HFimpEF. Multivariate logistic regression adjusted to ischemia-induced cardiomyopathy, IV HF NYHA class, and digoxin use yielded that NT-proBNP ≤1940 pmol/mL (OR = 1.43; 95% CI = 1.21-1.88, p = 0.001) and cf-nDNA ≤7.5 μmol/L (OR = 1.64; 95% CI = 1.19-2.15, p = 0.001) independently predicted HFimpEF. In conclusions: we established that the levels of cf-nDNA≤7.5 μmol/L independently predicted HFimpEF and improved discriminative ability of as single measured NT-proBNP as well as relative decrease in NT-proBNP levels ≤35% from baseline.

Preprint ARTICLE | doi:10.20944/preprints202407.1890.v1

Impaired Coordination of the Ciliary Movement in Patients with Chronic Rhinosinusitis with Nasal Polyps: The Role of Decreased Planar Cell Polarity Protein Expression

Sakura Hirokane, Tomohiro Kawasumi, Sachio Takeno, Yukako Okamoto, Seita Miyamoto, Rikuto Fujita, Chie Ishikawa, Takashi Oda, Yuichiro Horibe, Takashi Ishino, Takao Hamamoto, Tsutomu Ueda

Subject: Medicine And Pharmacology, Otolaryngology Keywords: paranasal sinus; chronic rhinosinusitis; CRS; nasal polyps; ciliated cell; mucociliary clearance; planar cell polarity; CPLANE complex proteins; WDPCP; FUZ

Online: 24 July 2024 (08:02:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0421.v1

Enhancing Post-Surgical Rehabilitation Outcomes in Patients with Chronic Ankle Instability: Impact of Subtalar Joint Axis Balance Exercises Following Arthroscopic Modified Broström Operation

Ji Myeong Park, Sang Ho Han, Byeong Chae Cho, Se Min Lee, Mal Soon Shin, Jae Ho Yu, Ho Jin Kim, Hyun Dong Noh, Min Suk Cho, Myung Ki Kim

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Anterior talofibular ligament; arthroscopic modified Broström operation; chronic ankle instability; subtalar joint axis balance exercises

Online: 4 January 2024 (14:30:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0506.v1

Chronic Morphine Treatment and Antiretroviral Therapy Exacerbate HIV-Distal Sensory Peripheral Neuropathy and Induce Distinct Microbial Alterations in the HIV Tg26 Mouse Model.

Irina Chupikova, Danielle Antoine, Richa Jalodia, Praveen Kumar Singh, Sabita Roy

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: HIV-associated pain; neuropathy; opioid use; antiretroviral therapy; gut dysbiosis; Tg26 mouse model

Online: 7 December 2023 (11:24:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1523.v1

IgG Antibody Responses to Epstein-Barr Virus in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Their Effective Potential for Disease Diagnosis and Pathological Antigenic Mimicry

André Fonseca, Mateusz Szysz, Hoang Thien Ly, Clara Cordeiro, Nuno Sepúlveda

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Biomarker discovery; disease pathogenesis; autoimmunity; antigenic mimicry; machine learning

Online: 23 November 2023 (11:10:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0595.v1

Effects of Multidisciplinary Biopsychosocial Rehabilitation on Short-Term Pain and Disability in Chronic Low Back Pain: A Systematic Review with Network Meta-Analysis

Ivan Jurak, Kristina Delaš, Lana Erjavec, Janez Stare, Igor Locatelli

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: chronic low back pain; multidisciplinary biopsychosocial rehabilitation; exercise therapy; network meta-analysis

Online: 9 November 2023 (07:44:33 CET)

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Chronic Low Back Pain (CLBP), defined as pain persisting for at least 12 weeks, is a significant public health issue, with prevalence intensifying due to an ageing global population, amassing approximately 619 million cases in 2020 and projected to escalate to 843 million by 2050. Given the multitude of therapeutic modalities available for CLBP, this research sought to ascertain their respective efficacies in ameliorating pain and disability. We specifically scrutinized Multidisciplinary Biopsychosocial Rehabilitation (MBR) among adults enduring non-specific low back pain for over 12 weeks, excluding acute pain conditions and pre-study surgical interventions. MBR is an approach encompassing various modalities, including exercise, behavioral therapies, educational programs, and work conditioning aspects, necessitating a comprehensive Network Meta-Analysis (NMA) to fully grasp the extensive scope of its impact. The constructed network comprised diverse MBR modalities (behavioral, educational, and work conditioning) alongside exercise therapy (ET), minimal intervention, and usual care, serving as controls with pain and disability as outcomes. Through the analysis of 4,619 initially identified studies, 93 were included, encompassing a total of 8,059 participants. The NMA conducted substantiated that both ET and MBR modalities were notably effective in alleviating CLBP, with education-oriented MBR emerging as the most efficacious for pain mitigation and behavior-focused MBR for disability reduction. Nevertheless, the discerned differences amongst the treatments were minimal and uncertain, highlighting that no modality was definitively superior to the others. The analysis revealed low global and local inconsistency within the network, underscoring the reliability of the observed outcomes. Given the intricate nature of CLBP, embodying various facets, our findings advocate for a combined therapeutic approach to optimize treatment efficacy. Nonetheless, the presence of high study heterogeneity and potential biases necessitates cautious interpretation of the results, prompting future research.

Preprint ARTICLE | doi:10.20944/preprints202310.0319.v2

Diabetes in a Dish: Modeling and Phenotyping Acute and Chronic Type 2 Diabetes Mellitus In Vitro in Rodent Heart and Skeletal Muscle Cells

Elena Luise Kopp, Daniel Nils Deussen, Raphael Cuomo, Reinhard Lorenz, David M Roth, Sushil K. Mahata, Hemal H Patel

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Insulin resistance; type 2 diabetes; cell model; mitochondrial dysfunction

Online: 8 November 2023 (04:07:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.1294.v1

The Mediating Effects of Social Networks and Wisdom on the Relationship between Lifestyle Habits and Healthy Aging in Older Adults with Chronic Diseases

Hee-Kyung Kim, Hye-Suk Oh, Cheol-Hee Park

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: elderly; healthy aging; lifestyle habits; social networks; wisdom; chronic disease

Online: 19 July 2023 (09:53:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1132.v1

Benefits of Chronic Administration of a Carbohydrate-Free Diet on Biochemical and Morphometric Parameters in a Rat Model of Diet-Induced Metabolic Syndrome

Diana Alejandra Lares-Gutiérrez, Marisol Galván-Valencia, Irene Jazmín Flores-Baza, Blanca Patricia Lazalde-Ramos

Subject: Public Health And Healthcare, Other Keywords: carbohydrate-free diet; metabolic syndrome; biochemical parameters; morphometric parameters; rat model.

Online: 15 June 2023 (11:32:49 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202305.2264.v1

Chronic Fatigue Syndrome and Multiple Sclerosis have Reduced Craniospinal Compliance and Dilated Pressurized Bridging Cortical Veins: A Hypothesis Illustrated with Two Case Studies

Grant Bateman, Alexander Bateman

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Chronic fatigue syndrome; myalgic encephalomyelitis; multiple sclerosis; cortical vein; venous pressure

Online: 31 May 2023 (14:31:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202301.0447.v1

Still Finding Ways to Augment the Existing Management of Acute and Chronic Kidney Diseases with Targeted Gene and Cell Therapies: Opportunities and Hurdles

Peter Corridon

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: acute kidney disease; chronic kidney disease; gene therapy; cell therapy

Online: 25 January 2023 (04:29:25 CET)

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Preprint REVIEW | doi:10.20944/preprints202010.0223.v1

Hydroa Vacciniforme and Hydroa Vacciniforme-like Lymphoproliferative Disorder: A Spectrum of Disease Phenotypes Associated with Ultraviolet Irradiation and Chronic Epstein-Barr Virus Infection

Chien-Chin Chen, Kung-Chao Chang, L. Jeffrey Medeiros, Julia Yu-Yun Lee

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Epstein-Barr virus; hydroa vacciniforme; lymphoproliferative disorders; photodermatosis; sunlight; skin; ultraviolet radiation

Online: 12 October 2020 (10:30:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201906.0271.v1

The Effect of Health-Related Behaviors on Disease Progression and Mortality in Early Stages of Chronic Kidney Disease: A Nationwide Population-Based Study

Yookyung Lee, SuYeon Kwon, JongJoo Moon, Kyungdo Han, Nam-Jong Paik, Won-Seok Kim

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: chronic kidney disease; disease progression; end stage renal disease; mortality; health-related behaviors; physical activity; smoking; alcohol

Online: 26 June 2019 (15:38:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0489.v1

Serum Creatinine Level and Its Relation to Backache in Chronic Kidney Disease with Unknown Aetiology (CKDu) Patients in North Central Province, Sri Lanka

Fahim Aslam, Nishantha Kumarasinghe

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: CKDu, e-GFR, S.Cr

Online: 25 September 2018 (15:35:59 CEST)

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Background - Chronic kidney disease with unknown aetiology (CKDu) is a progressing disease which is affecting many Sri Lankans’ yearly, this disease is slow progressive, irreversible and asymptomatic disease. Patients suffering from CKDu over the past two decades have been evaluated using the estimated glomerular filtration rate (e-GFR). This is the standard test performed under WHO guidelines to investigate and grade the CKDu, and this creatinine clearance is measured in this in order to grade the patient. Backache has been a common symptom presented in most of the chronic kidney disease patients (CKD), patients with CKDu are liable to get backache due to the renal failure that takes place (Jayathilake et al., 2013; Redmon et al., 2016). Objective – To detect a correlation between serum creatinine values and level of backache presented in the patient. Method -Using an interview based questionnaire to assess patients’ body condition and the degree of backache is assessed, 59 patients were part of the study for a period of five months and had an average age of 60.3 years. The questionnaire answers are scaled into four main types of backache from the least to the most painful based on the pain scale adapted from Kapkia. Serum creatinine is measured using an automated analyzer which is measured using Jaffe’s reaction. Using Pearson R correlation, the relationship was determined between serum creatinine and backache (Kafkia et al., 2011). Results – The results were obtained for 58 patients (n=58), where the mean backache score was 2.30 and mean serum creatinine value 2.77. The Pearson R value obtained was 0.01 which is indicating almost no relationship between backache and serum creatinine. Patients with stage 3 kidney disease (n=14) had an average E-GFR of 38.0, stage 4 (n=38) with 22.3 and stage 5 (n=6) with 14.0. Conclusion – Backache can be used an indicator of CKDu since it is presented in most patients’ suffering from the disease but unable to be used to determine the stage of CKDu suffered by the patient due to the external causes that leads to backache. Several predisposing factors such as temperature, water source and agricultural activity can influence the backache.

Preprint ARTICLE | doi:10.20944/preprints201701.0138.v1

Danggui-Shaoyao-San, a Traditional Chinese Medicine, Relieved Depression and Cognitive Disorder Induced by Chronic Restraint Stress Involved in Regulating Dendritic Spines Remodeling

Kecheng Zhou, Junbin Yin, Huanghui Wu, Wei Hu, Zhen Gao, Fang Li, An'an Wu, Wen Wang, Junping Kou

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Danggui-Shaoyao-San, chronic restraint stress, learning and memory, anxiety/depression, structural plasticity

Online: 31 January 2017 (15:30:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.0167.v1

Elucidating the Causal Link Between Hearing and Chronic Kidney Disease Through Mendelian Randomization and Development of Predictive Machine Learning Models Based on NHANES Data

Yanting Yang, Yuqing Li, Zhongquan Huang, Rongrong Lin, Zhuoni Chen, Ning Zhang, Nan Zheng, Jiean Xu, Yaqi Zhou

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Chronic kidney disease; Hearing; Mendelian randomization; Machine learning models; Predictions

Online: 2 August 2024 (10:56:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1478.v1

Contribution of echocardiography and 2D strain in the detection of subtle myocardial involvement in group A and B patients with chronic obstructive pulmonary disease

Rania Kaddoussi, Ikram Chamtouri, Wafa Dhouib, Elassoufi Fatima ezzahra, Monia Daami, Walid Jomaa, Wissal Rouetbi, Khaldoun Ben Hamda

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: chronic obstructive pulmonary disease; subtle myocardial involvement; echocardiography; strain

Online: 18 July 2024 (09:35:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1542.v1

Morphological and Functional Alterations in the CA1 Pyramidal Neurons of the Rat Hippocampus in the Chronic Phase of the Lithium-Pilocarpine Model of Epilepsy

Tatyana Y. Postnikova, Georgy P. Diespirov, Sergey L. Malkin, Alexander S. Chernyshev, Elizaveta N. Vylekzhanina, Aleksey V. Zaitsev

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: temporal lobe epilepsy; 4-aminopyridine model; pyramidal neuron; action potential; ictal discharge

Online: 24 June 2024 (04:32:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1694.v1

Impact of Shaking Exercise on Functional Recovery in Patients with Chronic Post-Stroke Upper Limb Paralysis: A Multicenter, Open-Label, Quasi-Randomized Controlled Trial

Takuya Hada, Toyohiro Hamaguchi, Masahiro Abo

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: stroke rehabilitation; upper limb paralysis; home-based training; self-training device; botulinum toxin type A

Online: 27 May 2024 (07:50:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0803.v1

Synergic Origin and Evolution of TDS, Mg and Fluoride in Groundwater As Relative to Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka

K.S.G.S. Priyadarshanee, Zhonghe Pang, Umaya Doss Saravana Kumar, E.A.N.V. Edirisinghe, H.M.T.G.A. Pitawala, J.D.C. Gunasekara:, W.M.G.S. Wijesooriya, Yifan Bao, Yinlei Hao, Jiao Tian

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: CKDu endemic; control; fluoride; water quality; evapo-concentration

Online: 13 May 2024 (06:47:16 CEST)

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The rural population in the Dry Zone of Sri Lanka is largely affected by Chronic Kidney Disease of Unknown etiology (CKDu). According to the multidisciplinary research carried out so far, quality of groundwater was considered one of the possible causative factors for CKDu. Therefore, the assessment of water quality variations and evolution mechanism of water quality parameters of drinking water sources is important for identifying any relationships between CKDu and the drinking water quality. The current study aimed to perform a detailed hydrogeochemical investigation using isotopic and chemical methods on selected groundwater sources in the CKDu-endemic, non-endemic and control areas. TDS, hardness, Mg2+, Na+ and F- are the main parameters that cause water quality deterioration but, their derived mechanism in these three regions are completely different. The excess concentrations of F- and Mg2+ in the CKDu endemic area, low F- and high Mg2+in the CKDu non-endemic sedimentary formation, and either combinations of low F- and low Mg2+, high F- and low Mg2+ or low F- with high Mg2+ in the control area are the distinct features. The primary processes that regulate the evolution of groundwater types in CKDu endemic and control area is the weathering of silicates. Similarly, in the CKDu endemic area, carbonate dissolution and reverse ion exchange are prominent. Cation exchange and evaporite dissolution are more pronounced in the control area. Shallow groundwaters are evapo-concentrated hence it further deteriorates quality when compared to the deep groundwater with non-mixed, non-evaporated, and higher elevation recharge effect (from 100 m altitude) in the CKDu endemic area. Dilution decreases the ion content in the CKDu endemic area while evaporite dissolution further increase it in the control area after the rainy season. Evaporation, and seawater mixing affected the quality of groundwater in the non-endemic sedimentary formation. A statistically significant difference of F- ionic ratio with Na+, Mg2+, Ca2+ in the endemic and control areas. Intense rock weathering combined with the desorption added excess F- to the groundwater in the CKDu endemic area while the cation exchange and fluorite dissolution is contributing factor in CKDu control area. All the groundwater samples analyzed have exceeded the moderate hardness threshold. However, prominent Mg hardness proportion together with excess F- in the CKDu endemic area may produce nephrotoxic MgF2 complexes that may trigger renal damage. In contrast, produced NaF complexes in the CKDu control area leads to reduction of F- toxicity in the human body. Therefore, increased levels of magnesium, fluoride and TDS in the shallow groundwater, along with geochemical, hydrogeological and climatic factors, may contribute to the CKDu in the Dry Zone of Sri Lanka.

Preprint ARTICLE | doi:10.20944/preprints202401.0666.v1

They Have Always Called Us Sick: Heterosexism and Medical Inequality for Queer Americans with Chronic Illness and a Potential New Direction for AIDS Discourses

B. Garrick Harden, Andre A. Favors

Subject: Social Sciences, Sociology Keywords: Queer Theory; Pandemics; Sexuality; AIDS Discourses; COVID Discourses

Online: 9 January 2024 (10:30:55 CET)

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Preprint REVIEW | doi:10.20944/preprints202305.0041.v1

A Significance of an Amelioration of Endothelial Dysfunction by Sodium-Glucose Cotransporter 2 Inhibitors for an Improvement of Heart Failure and Chronic Kidney Disease

Hidekatsu Yanai, Hiroki Adachi, Mariko Hakoshima, Hisayuki Katsuyama

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: endothelial dysfunction; chronic kidney disease; heart failure; sodium-glucose cotransporter 2 inhibitors

Online: 2 May 2023 (02:18:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0084.v1

A Comparative Analysis of Hypothalamic Pituitary Gonadal Axis Alterations by Chronic Consumptions of Broiler and Domestic Chicken Meats in Postnatal Sprague Dawley Male Rats

Muhammad Aslam

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Domestic chicken; Broiler chicken; Testosterone; Oxidative stress

Online: 6 February 2023 (07:38:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0152.v1

Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Massimo Sangiorgi, Mariangela Valentina Puci, Allegra Rosa Martelli, Teresa Messina, Paolo Frigatti, Maria Pia Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco Michelino Fiore, Armado Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, Diego Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Pietro Modugno, Maurizio Maiorano, Umberto Marcello Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, Giovanni Maria Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munaó, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio Stefano Tolva, Ilenia D'Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D'Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio Massimo Oddi, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: chronic limb-threatening ischemia; outcome; sex; age; limb salvage

Online: 8 December 2022 (09:39:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202208.0292.v1

Study the Correlation between the Mother-To-Child Transmission Risk Factors in Chronic Hepatitis B Virus Infection Pregnant Women in Vietnam by HCA Method

Tram Thi Ngoc Hoang, Thi Thu Huong Bui, Thi Thuy Pham, Thi Lan Anh Luong, Thi Kim Phuong Doan, Thu Lan Hoang, Cam Tu Ho, Nina Koerber, Khanh Lam Ho, Duc Hinh Nguyen, Tanja Bauer, Ulrike Protzer, Tien Dung Nguyen

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Chronic Hepatitis B Virus Infection; Liver; Pregnant Women; Cord blood; PBMCs (Peripheral Blood Mononuclear Cells); subclinical index

Online: 16 August 2022 (14:17:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0198.v1

Association of Serum and Urinary Magnesium Levels With Body Composition and Inflammatory Markers in Patients With Non-dialysis Chronic Kidney Disease: A Longitudinal Approach

Raimunda Sheyla Carneiro Dias, Dyego José de Araújo Brito, Cleodice Alves Martins, Elton Jonh Freitas Santos, Erika Cristina Ribeiro de Lima Carneiro, Elisangela Milhomen dos Santos, Denizar Vianna Araújo, Natalino Salgado Filho, Mario Bernardo Filho

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Magnesium deficiency; Body composition; Chronic kidney failure.

Online: 13 July 2022 (09:27:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0645.v1

Can a single trial of a thoracolumbar myofascial release technique reduce pain and disability in chronic low back pain? Randomized balanced cross-over study

Luana Rocha Paulo, Ana Cristina Rodrigues Lacerda, Fábio Luiz Mendonça Martins, José Sebastião Cunha Fernandes, Leonardo Sette Vieira, Cristiano Queiroz Guimarães, Sílvia de Simoni Guedes Ballesteros, Marco Túlio Saldanha dos Anjos, Patrícia Aparecida Tavares, Sueli Ferreira da Fonseca, Murilo Xavier Oliveira, Mário Bernardo-Filho, Danúbia da Cunha de Sá-Caputo, Vanessa Amaral Mendonça, Redha Taiar

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: fascia; chronic low back pain; myofascial release

Online: 25 March 2021 (16:24:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0143.v1

Income Levels and Mortality Rates in Patients with Chronic Kidney Disease in South Korea: a Population-Based Cohort Study Using National Health Insurance Data

Young Choi

Subject: Public Health And Healthcare, Health Policy And Services Keywords: chronic kidney disease; low socioeconomic status; mortality

Online: 6 August 2020 (09:46:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0495.v1

Acute and Chronic Effects of Exercise on Appetite, Energy Intake and Appetite-Related Hormones: the Modulating Effect of Adiposity, Sex and Habitual Physical Activity

James Dorling, David Broom, Stephen Burns, David Clayton, Kevin Deighton, Lewis James, James King, Masashi Miyashita, Alice Thackray, Rachel Batterham, David Stensel

Subject: Biology And Life Sciences, Food Science And Technology Keywords: appetite; energy intake; appetite-related hormones; energy balance; exercise; physical activity; energy compensation; weight control

Online: 25 July 2018 (16:20:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0392.v1

Amani Zidan, Ahmed Awaisu, Maguy El-Hajj, Samya Al-Abdulla, Dianne Figueroa, Nadir Kheir

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Medication-related burden; Questionnaire; chronic disease conditions; adherence

Online: 25 June 2018 (14:35:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints201705.0200.v1

The Thailand Declaration of the International College of Nutrition; Can Functional Foods and Functional Crops Decrease the Risk of Chronic Diseases and Provide Wellness?

Wiriya Phomkong, Ekasit Onsaard, Dherapol Bansiddhi, Ram B. Singh, Buncha Ooraikul, Arunporn Itharat, Fabien De Meester, Jagdish P. Sharma, Rana G. Singh, Usha Singh, Harpal S. Buttar, Istvan G. Telessy, Toru Takahashi, Lech Ozimek, Jae-Kwan Hwang, Kohei Oda, Douglas W. Wilson

Subject: Chemistry And Materials Science, Food Chemistry Keywords: Diet: Functional foods: Western foods: Mediterranean foods: Feeding, Plant breeding

Online: 29 May 2017 (17:38:59 CEST)

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There is evidence that optimal nutrition is fundamental to human health and in the prevention of non-communicable diseases (NCDs) later in adult life. The identification, production and consumption of functional foods worldwide can increase health benefits for all who can access and afford such foods subject to advice from nutritionists. Recent meetings organized by the health agencies, give a crucial opportunity to make nutrition, a central part of the post-2015 sustainable human and agricultural development agenda. The aim of discussions in these meetings was to provide functional crops and foods to achieve optimal health by prevention of NCDs. It is possible that these efforts might ensure that the goals and targets set in the agenda are adequate to address the many challenges of global undernutrition as well as obesity which are major risk factors of NCDs. In many developing and middle income countries, food security provided by the governments, in one sense understandably, gave least consideration to functional foods supply and the prevention of obesity and metabolic syndrome, resulting in to emergence of NCDs. The Thailand Declaration reiterates that commitments to eradicate hunger and undernutrition as well as over-nutrition, and to increase investments in effective interventions; designers foods and designers crops. However, in planning coherent policies, our past experience on rapidly absorbed, energy-rich processed foods should be taken in to account while developing sustainable food systems. The food industry should be educated to exploit the expertise of food scientists and health professionals in designing functional foods taking cognizance of manufacturing and processing. Similarly, agriculture scientists may be actively involved in educating farmers so as to grow cash crops providing functional foods. The aim should be to achieve an increase in the availability of functional foods to an extent, or by a policy, by which such foods are available to poors, at affordable cost to prevent hunger and undernutrition and related diseases as well as NCDs. In addition our efforts might help in developing an international consensus on how to approach the development of new designer foods by farmers and food industry to produce low glycemic index foods. Such efforts may establish an international framework for the prevention of NCDs, so that human susceptibility to these diseases is substantially diminished.

Preprint ARTICLE | doi:10.20944/preprints202408.1632.v1

Symptomatologic Profile and Associated Factors Observed in Patients with Dengue

Camila Marcondes de Oliveira, Fábio Tadeu Reina Rodrigues, Márcia Mesquita Serva, Fernanda Mesquita Serva, Jefferson Aparecido Dias, Mayra André Coube Menezes, Isabella Bispo Diaz Toledo, Eduardo Federighi Baisi Chagas, Enzo Pereira de Lima, Lucas Fornari Laurindo, Sandra Barbalho

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Dengue; DENV 1, 2, 3 e 4; Aedes spp; Hematologic Diseases; Leukopenia; Cardiovascular Symptoms; Hypertension

Online: 22 August 2024 (14:51:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2300.v1

Implementation of Methylation Profiling of Central Nervous System Tumors At Largest Public Health Center in Brazil

Beatriz Martins Wolff, Yuri Reis Casal, Lucas Liro Vieira, Gleyson Francisco da Silva Carvalho, Mariana Ribeiro Costa, Rafela Mendes da Silva, Maria Fernanda Freire Chagas, Lissandro Sousa Rolim, Yanca Gasparini Oliveira, Eder Alencar Moura, Felipe D'Almeida Costa, Leslie Domenici Kulikowski

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Cancer; Methylation; Array; Medulloblastoma; Ependymoma

Online: 29 July 2024 (13:09:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2562.v1

Comparative Analysis of the Effect of Beta Blockers of Different Generations on the Parameters of Myocardial Energy Metabolism in Experimental Doxorubicin-Induced Chronic Heart Failure

Igor Belenichev, Olexiy Goncharov, Nina Bukhtiyarova, Oleh Kuchkovskyi, Victor Ryzhenko, Lyudmyla Makyeyeva, Valentyn Oksenych, Oleksandr Kamyshnyi

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: chronic heart failure; beta blockers; energy metabolism; mitochondria; Hypertril

Online: 31 July 2024 (12:36:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1492.v1

Ceftazidime-Avibactam Use in a Cohort of Children with Complex Chronic Conditions: Effectiveness and Absence of Resistance Development Following Difficult-to-Treat or Recurrent Infections

Miguel García-Boyano, María Alós Díez, Lorena Fernández Tomé, Luis Escosa-García, Francisco Moreno Ramos, Cristina Schuffelmann-Gutiérrez, Emilio Cendejas Bueno, Cristina Calvo, Fernando Baquero-Artigao, Esteban Frauca Remacha

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: ceftazidime-avibactam; carbapenem-resistant enterobacteriaceae; beta-lactamase OXA-48; Klebsiella pneumoniae; child; liver transplantation; intraabdominal infections; cholangitis

Online: 23 May 2024 (07:18:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0348.v1

Accuracy of Anti-SARS-CoV2 Antibody in Comparison with Surrogate Viral Neutralization Test in Person Living with HIV, Systemic Lupus Erythematosus and Chronic Kidney Disease

Marita Restie Tiara, Chrisan Bimo Prayuda, Tara Titian Maulidya, Hofiya Djauhari, Dadang Suhendar, Rudi Wisaksana, Laniyati Hamijoyo, Rudi Supriyadi, Agnes Rengga Indrati, Bachti Alisjahbana

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; vaccination; antibody; immunoassay; neutralization antibody

Online: 4 April 2024 (05:53:47 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202304.1068.v1

The Importance of Arterial Blood Gas Analysis as a Systemic Diagnosis Approach in Assessing and Preventing Chronic Diseases, From Emergency Medicine to the Daily Practice

Mario Giosue' Balzanelli, PIETRO DISTRATIS, RITA LAZZARO, Van Hung Pham, Raffaele Del Prete, Gianna Dipalma, Francesco Inchingolo, Sergey Khachatur Aityan, Linh thuy Hoang, Kieu Cao Diem Nguyen, Ciro Isacco gargiulo

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Key words: arterial blood gas analysis (ABG); partial pressure of oxygen (PaO2); partial pressure PaCO2 (PaCO2); serum bicarbonate (HCO3); Hasselbach; acid/base

Online: 27 April 2023 (10:04:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0182.v1

In Schizophrenia, Chronic Fatigue Syndrome- and Fibromyalgia-Like Symptoms are Driven by Breakdown of the Paracellular Pathway with Increased Zonulin and Immune Activation-Associated Neurotoxicity

Michael Maes, Laura Andrés-Rodríguez, Aristo Vojdani, Sunee Sirivichayakul, Décio Barbosa, Buranee Kanchanatawan

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: chronic fatigue syndrome; Myalgic encephalomyelitis; oxidative stress; neuro-immune; inflammation; bacterial translocation

Online: 10 May 2021 (12:27:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0303.v1

Analysis of the Dimensions of Physiotherapy Index of Ventilatory Workload in People with Chronic Obstructive Pulmonary Disease During Stability and Exacerbation in An Outpatient Setting

Rodrigo Muñoz Cofré, Mariano del Sol, Paul Medina González, Jorge Valenzuela Vásquez, Gerardo Molina Vergara, Ramón Pinochet Urzúa, Pablo A. Lizana, Máximo Escobar Cabello

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: ventilatory assessment; physiotherapy; chronic obstructive pulmonary disease

Online: 29 August 2019 (04:52:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0186.v1

The Effect of Pain Relief on Daily Physical Activity: in-Home Objective Physical Activity Assessment in Chronic Low Back Pain Patients after Paravertebral Spinal Block

Tzu Chuan Yen, Jane Mohler, Michael Dohm, Kaveh Laksari, Bijan Najafi, Nima Toosizadeh

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Gait; Pain; Back disorder; Outcome evaluations; Daily activity; Fear of pain

Online: 9 August 2018 (11:26:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0440.v1

Chronic Pediatric Headache as a Manifestation of Shunt Over-Drainage and Slit Ventricle Syndrome in patients harboring a Cerebrospinal Fluid Diversion System: A Systematic Literature Review

Dimitrios Panagopoulos, Maro Gavra, Efstathios Boviatsis, Stefanos Korfias, Marios Themistocleous

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: over-drainage; slit ventricle syndrome; anti-siphon device; programmable valve

Online: 5 April 2024 (12:11:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1320.v1

Severe Type 2 Inflammation Leads to High PAF-Associated Pathology in Chronic Rhinosinusitis with Nasal Polyps (CRSwNP): Hierarchal Cluster Analysis Using Bulk RNA Barcoding and Sequencing

Takashi Ishino, Takashi Oda, Tomohiro Kawasumi, Kota Takemoto, Manabu Nishida, Yuichiro Horibe, Nobuyuki Chikuie, Takayuki Taruya, Takao Hamamoto, Tsutomu Ueda, Sachio Takeno

Subject: Medicine And Pharmacology, Otolaryngology Keywords: Paranasal sinuses; Chronic rhinosinusitis (CRS); BRB-seq; Nasal polyps; Differentially Expressed Genes (DEG) analysis; Hierarchal analysis; Pathway analysis; Type 2 inflammation; LPCAT1; LPCAT2, PAFAH1B2, PAFAH1B3; PAFAH2; PTAFR

Online: 17 January 2024 (13:57:17 CET)

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Platelet-activating factor (PAF) is a phospholipid-derived inflammatory mediator, triggering various inflammatory conditions, including eosinophil activation and recruitment. Despite the unclear mechanism underlying the formation and maintenance of nasal polyp in chronic rhinosinusitis with nasal polyps (CRSwNP), there is strongly indication of its association with type 2 inflammation. This study aimed to quantify PAF-associated gene expression, examining enzymes involved in PAF synthesis (lysophosphatidylcholine acyltransferase 1 (LPCAT1), LPCAT2, LPCAT3, and LPCAT4), and PAF degradation (PAF acetylhydrolases 1 B2 (PAFAH1B2), PAFAH1B3, and PAF acetylhydrolases 2 (PAFAH2)), and PAF receptor (PTAFR). Transcriptomic analysis encompassed CRSwNP, including eosinophilic CRS (ECRS) (n=9), nonECRS (n=8), and a subgroup of ECRS with aspirin exacerbated respiratory disease (Asp) (n=3) based on the Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC) criteria. Gene expression profiles from nasal polyps in CRSwNP patients and the uncinate process in normal subjects (controls) (n=6) were analyzed using bulk RNA barcoding and sequencing (BRB-seq). Hierarchal analysis, utilizing the average linkage method with iDEP1.1, clarified the relationship between Differentially Expressed Genes (DEG) expressions and cluster formation. Two clusters (cluster 1 (n=11) and cluster 2 (n=9)) of CRSwNP divided by hierarchal analysis showed distinct gene expression profiles in the specific pathway of “cytokine-cytokine receptor interaction” in KEGG pathway and upregulated type 2 inflammatory gene expression in cluster 2. In CRSwNP subclassification of ECRS, nonECRS, and Ctrl, PTAFR was only upregulated in ECRS and nonECRS. In cluster analysis, cluster 1 showed significant downregulation of LPCAT2 and upregulation of PTAFR expression, while cluster 2 showed significant upregulation of LPCAT1, PAFAH1B2, and PTAFR and downregulation of PAFAH2 expression. These findings suggest that cluster 2, characterized by severe type 2 inflammatory gene expression, manifest a prominent PAF-associated pathophysiology. Understanding this high PAF-associated pathophysiology in cluster 2 could provide valuable insights into the treatment and management of CRSwNP.

Preprint ARTICLE | doi:10.20944/preprints202309.0042.v1

Synergistic Effect of Dietary Acid Load Levels and Cigarette Smoking Status on the Risk of Chronic Obstructive Pulmonary Disease (COPD) in Middle-Aged Healthy Korean Men

Jihyun Park, Mi Ri Ha, Juhyun Song, Oh Yoen Kim

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: dietary acid load; net endogenous acid production; chronic obstructive pulmonary disease; KNHANES

Online: 1 September 2023 (10:11:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0311.v1

Retrospective Cross-Sectional Study on Chronic Hepatitis C in Estonia, Latvia, Lithuania, and Ukraine: Virus, Patient, and Disease Characteristics in Patients under Care (RESPOND-C Study)

Ligita Jančorienė, Baiba Rozentāle, Ieva Tolmane, Agita Jēruma, Riina Salupere, Arida Buivydienė, Jonas Valantinas, Limas Kupčinskas, Jolanta Šumskienė, Eglė Čiupkevičienė, Arvydas Ambrozaitis, Olga Golubovska, Larysa Moroz, Robert Flisiak, Borys Bondar

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Baltic states; chronic hepatitis C; epidemiology; hepatitis C virus; genotype; Ukraine

Online: 5 July 2023 (12:30:04 CEST)

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Background and objectives: Since 2013, highly effective direct-acting (DAA) chronic hepatitis C (CHC) antiviral therapy became available, which has cure rates of over 95%. For choice of optimal CHC treatment, assessment of hepatitis C virus (HCV) genotype (GT) and liver fibrosis stage are necessary. Information about distribution of these parameters among CHC patients in Baltic states and especially in Ukraine is scarce. This study was performed to obtain epidemiological data regarding CHC GT and fibrosis stage distribution for better planning of resources and prioritization of patients for DAA drug treatment according to disease severity in high-income (Baltic states) and lower-middle income (Ukraine) countries. Materials and Methods: This was an epidemiological, retrospective, cross-sectional study that included 1451 CHC patients. Demographic and disease information from medical charts was collected for each patient during a single visit. Results: Most frequent suspected mode of viral transmission was blood transfusions (17.8%), followed by injection drug use (15.7%); however, in 50.9% of patients exact mode of transmission was not clarified. In Ukraine (18.4%) and Estonia (26%) transmission by the injection drug use was higher than in Lithuania (5%) and Latvia (5.3%). Distribution of HCV GT among patients with CHC was as follows: GT1 - 66.4%; GT3 - 28.1; and GT2 - 4.1%. The prevalence of GT1 was the highest in Latvia (84%), and the lowest in Ukraine (63%, p<0.001). Liver fibrosis stages were distributed as follows: F0 - 12.2%, F1 - 26.3%, F2 - 23.5%, F3 – 17.1% and F4 - 20.9%. Cirrhosis (F4) was more prevalent in Lithuanian patients (30.1%) than in Estonians (8.1%, p <0.001). Conclusions: This study contributes to the knowledge of epidemiological characteristics of HCV infection in the Baltic states and Ukraine. The data regarding the patterns of HCV GT and fibrosis stage distribution will be helpful for the development of national strategies to control HCV infection in the era of DAA therapy.

Preprint REVIEW | doi:10.20944/preprints202307.0005.v2

The Potential Role of Hypothalamic Phospholipid Liposomes in the Supportive Therapy of Some Manifestations of Post COVID-19 Condition: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Brain Fog

Francesco Menichetti

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Covid-19; post-COVID syndrome; neuroendocrine disorders; chronic fatigue; brain fog; phospholipids; phospholipid liposome; phosphatidylserine

Online: 15 August 2023 (05:03:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1686.v1

Transcriptomic Analysis Reveals Early Alterations Associated with Intrinsic Resistance to Target Therapy in Lung Adenocarcinoma Cell Lines

Mario Perez-Medina, Jose Sullivan Lopez-Gonzalez, Jesus J. Benito-Lopez, Santiago Ávila-Ríos, Maribel Soto-Nava, Margarita Matias-Florentino, Alfonso Méndez-Tenorio, Miriam Galicia-Velasco, Rodolfo Chavez-Dominguez, Sergio E. Meza-Toledo, Dolores Aguilar-Cazares

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: lung adenocarcinoma; drug-tolerant persister (DTP) cells; intrinsic resistance; tyrosine kinase inhibitors (TKIs); erlotinib; osimertinib; senescent cells; CD74

Online: 28 March 2024 (12:16:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0414.v1

Triple Therapy De-escalation and Withdrawal of Inhaled Corticosteroid to Dual Bronchodilator Therapy in Patients with Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review and Meta-Analysis

Edoardo Pirera, Domenico Di Raimondo, Antonino Tuttolomondo

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Chronic Obstructive Pulmonary Disease (COPD); inhaled corticosteroids (ICS); de-escalation therapy; Acute Exacerbation of COPD (AECOPD); pneumonia; eosinophils

Online: 6 September 2024 (05:51:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0405.v1

Effectiveness and Tolerability of Anti-Calcitonin Gene-related Peptide Therapy for Migraines and Other Chronic Headaches in Adolescents and Young Adults: A Retrospective Study in the USA

Anjaneya Shankar Madhav Bandatmakur, Pooja Dave, Melissa Kerr, Colin Brunick, Sijin Wen, Nicholas Hansen

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: pediatric headache; migraine; anti- CGRP; headache; anti migraine

Online: 6 August 2024 (10:41:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0253.v1

Links between Serotonin Levels and Stress: Cortisol, Candida A./Mycetes, Omega 3/6 Ratio and Dysbiosis (Skatole/Indoxyl Sulfate) Role in Chronic Fatigue Syndrome (CFS) and Depression

Daniele Orlandoni, Giuseppe Di Fede, Mauro Mantovani, Consuelo Rubina Nava, Marco Tomasi, Paola Fusi

Subject: Biology And Life Sciences, Other Keywords: stess; chronic fatigue syndrome; depression; dysbiosis; serotonin/cortisol

Online: 5 September 2023 (07:52:50 CEST)

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Intestinal microbiota attracts daily attention of a growing number of study which have attempted to link gut dysbiosIs with a variety of disease states: irritable bowel syndrome (IBS), inflamed bowel disease (IBD), Crohn's disease (CD), leaky gut syndrome (LGS), food intolerance, diabetes, metabolic syndrome, cancer, etc.. In our study we analyzed how intestinal dysbiosis may be related to chronic fatigue syndrome (CFS) and depression through the exchange of information through the gut-brain axis (GBA). We studied 33 subjects, 13 males and 20 females, who reported CFS or/and depression: we investigated their salivary cortisol levels, blood serotonin, omega 3/6 ratio, intestinal dysbiosis (calculated on the urinary levels of indoxyl sulfate and skatole), and we looked for the presence of Candida a. or mycetes in the stool; the data accumulated with this research show a correlation between the presence of Candida a./miceti, indoxyl sulfate urine values beyond the physiological and low serotonin levels. In addition, data analysis showed that the EPA/DHA values also show pro-inflammatory levels in case of dysbiosis and low serotonina levels. The relationship, however, with cortisol levels requires further research although this study showed a statistically significant positive correlation between these values, measured at specific times, and serotonin levels. Aims its connections with We investigated the relationship between stress (evaluated through the measurement of salivary cortisol levels) and gastrointestinal efficiency measured as a function of intestinal fermentative and putrefactive dysbiosis, evaluating the levels of urinary indoxyl sulfate in the first case (a possible correlation with the presence of Candida spp or Mycetes in the subjects feces was investigated), urinary skatole levels in the second one, in patients with chronic fatigue syndrome (SFC) and depression. In these patients we also have studied omega 3/6 ratio, and finally we have analized the impact that the alteration of these parameters can have on the serotonin levels. This research attemps to highlight the contact points, in some cases not so obvious, among these topics, contact points that, although they give us interesting indications, show the need to be further deepened by analyzing a larger amount of data.

Preprint ARTICLE | doi:10.20944/preprints202307.1305.v1

Atherogenic Dyslipidemia in Wistar Rats: Study of the Association of Fixed Oils from Abelmoschus esculentus (L.) Moench., Euterpe oleracea Martius., Bixa orellana Linné and Chronic SM®

Priscila Faimann Sales, ALINE LOPES DO NASCIMENTO, Fernanda Cavalcante Pinheiro, Andressa Ketelem Meireles Alberto, Abrahão Victor Tavares de Lima Teixeira dos Santos, Helison de oliveira Carvalho, Gisele Custódio De Souza, And José Carlos Tavares Carvalho

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Hypercholesterolemia; Atherosclerosis; vegetable oils

Online: 20 July 2023 (03:20:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0622.v1

Short-term Effects of Manual Therapy Plus Capacitive and Resistive Electric Transfer Therapy in Individuals with Chronic Non-specific Low Back Pain: A Randomized Clinical Trial Study

Konstantinos Kasimis, Paris Iakovidis, Dimitrios Lytras, Georgios Koutras, Ioanna P. Chatziprodromidou, Antonis Fetlis, Stefania Rafailia Ntinou, Natalia-Maria Keklikoglou, Antigoni Samiotaki, Georgios Chasapis, Georgia Tarfali, Thomas Apostolou

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Keywords: Chronic Low back pain; Manual therapy; Capacitive and Resistive Electric Transfer Therapy

Online: 8 June 2023 (10:13:14 CEST)

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Background: Chronic non-specific low back pain (CNSLBP) is defined as back pain that lasts longer than 12 weeks. Objectives: To investigate the efficacy of manual therapy (MT) program combined with Capacitive and Resistive Electric Transfer (TECAR) therapy in individuals with CNSLBP. Method: Sixty adults with CNSLBP were randomly equally divided into three groups. The first group followed an MT protocol in the lumbar region (MT group), the second group followed the same MT protocol combined with TECAR therapy (MT + TECAR group) using a conventional capacitive electrode as well as a special resistive electrode bracelet and the third group (Control group) received no treatment. Both intervention programs included six treatments over two weeks. Pain in the last 24 hours with the Numeric Pain Rating Scale (NPRS), functional ability with the Roland-Morris Disability Questionnaire (RMDQ), Pressure Pain Threshold (PPT) in the lumbar region with pressure algometry, and mobility of the lumbo-pelvic region through fingertip-to-floor distance (FFD) test were evaluated before and after the intervention period with a one-month follow-up. Analysis of variance with repeated measures was applied. Results: In the NPRS score, both intervention groups showed statistically significant differences compared to the control group both in the second week as well as in the one-month follow-up (p < .001). Between-groups differences were also noticed between the two intervention groups in the second week (p < .05). Differences in the RMDQ score in the second week and on the one-month follow-up were detected between the intervention groups and the control group (p < .001), while differences between the two intervention groups were only detected in the one-month follow-up (p < .001). Regarding the PPT values, differences were found mainly between the MT + TECAR and the control group and between the MT + TECAR and the MT group (p < .05), with the MT + TECAR group in most cases showing the greatest improvement compared to the other two groups, which remained statistically significant in the one-month follow-up (p < .05). Finally, both intervention groups improved the mobility of the lumbo-pelvic region in both time points compared to the control group without, however, statistically significant differences between them (p> .05). Conclusion: The application of an MT protocol with TECAR therapy appeared more effective than conventional MT as well as compared to the control group in reducing pain and disability and improving PPT in individuals with CNSLBP. No further improvement was noted in mobility of the lumbo-pelvic region by adding TECAR to the MT intervention.

Preprint ARTICLE | doi:10.20944/preprints202201.0371.v2

Observational Pilot Study: A comparison of Amino Acids and Derangement of Intestinal Function between Healthy Ageing Subjects and Patients Affected by Chronic Kidney Disease in Conservative Management

Piergiorgio Bolasco, Roberto Aquilani, Roberto Maestri, Maria Paola Esposito, Maria Luisa Deiana, Mariella Cadeddu, Romina Secci, Barbara Casu, Antonella Serra, Paolo Iadarola, Maura D'Amato, Stefano Murtas

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Chronic Kidney Disease; aminoacids; Dysbiosis; metabolic disorders

Online: 27 January 2022 (15:48:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0455.v1

Depression, Anxiety, and Chronic Fatigue Symptoms in Acute Rheumatoid Arthritis are Associated with Immune-inflammatory, Autoimmune, Endogenous Opioid System and Lactosylceramide Signaling Pathways: A Nomothetic Network Approach

Hasan Smesam, Hasan Qazmooz, Sinan Khayoon, Hussein Al-Hakeim, Michael Maes

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: inflammation; neuro-immune; cytokines; major depression; chronic fatigue syndrome; affective disorders

Online: 27 September 2021 (16:30:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0362.v1

Intersections between Pneumonia, Lowered Oxygen Saturation Percentage and Immune Activation Mediate Depression, Anxiety and Chronic Fatigue Syndrome-like Symptoms due to COVID-19: A Nomothetic Network Approach

Hawraa Al-Jassas, Hussein Al-Hakeim, Michael Maes

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; depression; chronic fatigue syndrome; inflammation; neuro-immune; psychiatry

Online: 14 June 2021 (13:01:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1499.v1

Next-Generation DNA Sequencing Identifies Mutated FANCD2 Gene as a Novel Biomarker for Monitoring Early Disease Progression and Timely Therapeutic Interventions in Advanced Phase Chronic Myeloid Leukemia Patients

Nawaf Alanzazi, Abdulaziz Siyal, Muhammad Absar, Masood Shammas, Sarah Almukhaylid, Amer Mahmood, Zafar Iqbal

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Chronic Myeloid Leukemia; CML progression; Poor survival; genomic instability; DNA repair; FANCD2

Online: 20 December 2023 (04:54:34 CET)

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Chronic Myeloid Leukemia, resulting due to chromosomal aberration t(9;22) through formation of oncogenic BCR-ABL fusion oncogene. Modern BCR-ABL inhibitors, called TKIs, have revolutionized CML treatment. CML has three stages: chronic, accelerated, and blast crisis. TKIs work well in CP-CML, where patients survive as long as the normal population, but they don't work in AP- and BC-CML. Even with advances in treatment, BC-CML has an average overall survival of less than a year, giving oncologists little time to clinically intervene. Oncologists can delay or prevent CML advancement by detecting patients at risk of disease progression early and making timely treatment decisions, especially with third and fourth generation TKIs. However, no universal molecular biomarkers exist to diagnose CML patient groups at risk of disease progression. A recent study found that all BC-CML patients have mutant FANCD2. Our study was designed to detect mutant FANCD2 in AP-CML (early progression phase) to investigate its potential as a novel biomarker of early CML progression from chronic phase to accelerated phase due to the urgent need for such a biomarker. Our study comprised of 123 CP-CML (control group) and 60 AP-CML patients (as experimental group) from Hayatabad Medical Complex, Peshawar, Pakistan, from Jan 2020 to July 2023. DNA was extracted from the patients and FANCD2 gene was sequenced using Illumina next generation sequencer (NGS) Illumina MiSeq sequencer. NGS analysis revealed a unique splice site mutation in FANCD2 gene (c. 2022-5C>T). This mutation was detected in all CP-CML patients but in none of CP-CML. The mutation was confirmed by Sanger sequencing. FANCD2 is member of Fanconi anemia (FA-) pathway gene involved in DNA repair and genomic instability. Therefore, our studies show that FANCD2 (c. 2022-5C>T) mutation as a very specific molecular biomarker for early CML progression. We recommend to clinical validate this biomarker is prospective clinical trials.

Preprint ARTICLE | doi:10.20944/preprints202312.0023.v1

From a Clustering of Adverse Symptoms After Colorectal Cancer Therapy to Chronic Fatigue and Low Ability to Work: A Cohort Study Analysis With 3 Months of Follow-Up

Tomislav Vlaski, Marija Slavic, Reiner Caspari, Bettine Bilsing, Harald Fischer, Hermann Brenner, Ben Schöttker

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: colorectal cancer; rehabilitation; fatigue; ability to work; symptom clusters

Online: 1 December 2023 (03:33:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0336.v1

In End-Stage Renal Disease, the Effects of Hemodialysis on Chronic Fatigue Syndrome- and Fibromyalgia-Like Symptoms are Mediated via Inflammatory Biomarkers, Copper and Wnt/Catenin Pathway Proteins

Halah Asad, Hussein Al-Hakeim, Shatha Moustafa, Michael Maes

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Myalgic Encephalomyelitis/chronic fatigue syndrome; Wnt pathway; inflammation; neuro-immune; oxidative stress; biomarkers

Online: 12 March 2021 (08:46:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0917.v1

Comparative Analysis of Vascular Calcification Risk Factors in Pre-hemodialysis and Prevalent Hemodialysis Adult Patients: Insights into Calcification Biomarker Associations and Implications for Intervention Strategies in Chronic Kidney Disease

Marko Petrović, Voin Brković, Marko Baralić, Ivko Marić, Nenad Petković, Sanja Stanković, Nataša Lalić, Danijela Stanisavljević, Ljubica Đukanović, Višnja Ležaić

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: chronic kidney disease; vascular calcifications; FGF-23; Fetuin-A; sclerostin; iPTH; Adragao score

Online: 17 February 2024 (09:04:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202304.0080.v1

Adapting Clinical Practice Guidelines for Chronic Kidney Disease: Blood Pressure Management and Kidney Replacement Therapy in Adults and Children in the Saudi Arabian context using the GRADE-ADOLOPMENT methodology

Khalid Abdulaziz Alhasan, Juan José Yepes-Nuñez, Sumayah Askandarani, Yasser Sami Amer, Muneera Al-Jelaify, Khalid I. Almatham, Mohammed Al-Ghonaim, Sultan Al Dalbhi, Jameela Abdulaziz Kari, Ahmed Mitwalli, Ziad Memish, Joanna Sara Valson, Ximena Alvira, Khushnam Bilimoria, Ruchi Chawla, Sheila Feit, Skye Bickett, Klara Brunnhuber

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: chronic kidney disease; antihypertensive; practice guidelines; recommendations; performance measures; GRADE; adolopment; AGREE II; RIGHT-Ad@pt; evidence-based healthcare; Saudi Arabia

Online: 6 April 2023 (08:59:14 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202009.0009.v1

Efficacy of Double Dose Dapsone Combination Therapy in the Treatment of Chronic Lyme Disease/Post-Treatment Lyme Disease Syndrome (PTLDS) and Associated Co-infections: A Report of Three Cases

Richard Horowitz, Phyllis R. Freeman

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Lyme disease; Post-Treatment Lyme Disease Syndrome (PTLDS); dapsone combination therapy (DDS CT); double dose dapsone combination therapy (DDD CT); babesiosis; persistent infection

Online: 1 September 2020 (11:30:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1715.v1

Effects of a Therapeutic Exercise Protocol for the Prevention of Vertebral Pain in Patients with Chronic Non-Specific Back Pain in Primary Health Care: A Single-Group Retrospective Cohort Study

Juan Nicolás Cuenca-Zaldívar, Josué Fernández-Carnero, Eleuterio A. Sánchez Romero, Verónica Alvarez-Gonzalo, Rocío Conde-Rodríguez, David Rodriguez-Sanz, Cesar Calvo-Lobo

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: low back pain; musculoskeletal diseases; neck pain; physical therapy

Online: 24 August 2023 (07:16:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201906.0243.v1

Serum Agrin and Talin, Two Muscular Proteins, are Significantly Increased in Major Depression and Increased Agrin and Lowered Creatine Phosphokinase are Associated with Chronic Fatigue and Fibromyalgia Symptoms in Depression

Hussein Kadhem Al-Hakeim, Ameer Abdul Razzaq Al-Issa, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: major depression; chronic fatigue; fibromyalgia; neuro-immune; inflammation

Online: 24 June 2019 (10:19:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1738.v1

Novel Insight into the Effect of Balneotherapy on Changes in the Functional State in Patients with Chronic Low Back Pain: Integration of Physical and Mental Healthcare Indicators and Patients’ Health Perception

Dragana Terzic Markovic, Sanja Kocic, Jovana Bradic, Aleksandra Jurisic Skevin, Biljana Jakovljevic, Biljana Majstorovic, Zvonko Dimoski, Goran Stojanovic, Vesna Maksimovic, Katarina Pavlovic Jugovic, Marijana Dabic, Danijela Jezdimirovic, Sandra Zivanovic

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: chronic low back pain; balneotherapy; functionality; life quality; pain

Online: 23 July 2024 (07:40:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0426.v1

Association Between Insertion-Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Treatment Response to Antipsychotic Medications: A Study of Antipsychotic-Naïve First-Episode Psychosis Patients and Nonadherent Chronic Psychosis Patients

Sergej Nadalin, Sanja Dević Pavlić, Vjekoslav Peitl, Dalibor Karlović, Lena Zatkovic, Smiljana Ristić, Alena Buretić-Tomljanović, Hrvoje Jakovac

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: angiotensin-converting enzyme (ACE); antipsychotic medication; polymorphism, insertion/deletion; treatment response

Online: 28 September 2022 (03:12:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0898.v1

Unraveling the Influence of Litter Size, Maternal Care, Exercise, and Aging on Neurobehavioral Plasticity and Dentate Gyrus Microglia Dynamics in Rats

Lane Viana Krejcová, João Bento-Torres, Daniel Guerreiro Diniz, Antonio Jr. Pereira, Manuella Batista-de-Oliveira Hornsby, Andreia Albuquerque Cunha Lopes de Morais, Rosângela Figueiredo Mendes-da-Silva, Ricardo Abadie Guedes, Ângela Amâncio dos Santos, Denise Sandrelly Lima, Rubem C.A. Guedes, Cristovam Wanderley Picanço-Diniz

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: maternal care; litter size; microglia; dentate gyrus; exercise; age-related memory impairments; object recognition

Online: 15 April 2024 (05:22:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0264.v1

Dietary Intake and Oral Glucose Tolerance Test Results in Women with Gestational Diabetes

Lucas Almeida das Chagas, Maria Regina Torloni, Luiz Gonzaga Ribeiro Silva-Neto, Patricia Medici Dualib, Rosângela Maria Lopes de Sousa, Jalila Andréa Sampaio Bittencourt, Edward Araujo Júnior, Roberta Granese, Rosiane Mattar

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: gestational diabetes mellitus; diet; glucose tolerance test

Online: 3 April 2024 (08:20:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1397.v1

Regional-Scale Cotton Yield Estimate in the Brazilian Cerrado Using Simple Linear Regression Models with Time-Series of Vegetation Indices from EOS-MODIS Satellite Data

Daniel A. B. de Siqueira, Carlos M. P. Vaz, Flávio S. Silva, Ednaldo J. Ferreira, Eduardo A. Speranza, Júlio C. Franchini, Rafael Galbieri, Jean L. Belot, Márcio de Souza, Fabiano J. Perina, Sérgio das Chagas

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: remote sensing; yield prediction; cotton; Brazilian Cerrado

Online: 26 February 2024 (07:25:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0236.v1

Platelet-to-Lymphocyte Ratio (PLR), Neutrophil-to-Lymphocyte Ratio (NLR), and Monocyte-to-Lymphocyte Ratio (MLR), and Eosinophil-to-Lymphocyte Ratio (ELR) as Biomarkers in Patients with Acute Exacerbation Chronic Obstructive Pulmonary Disease.

Qian-Qian Liao, Yan-Ju Mo, Ke-Wei Zhu, Feng Gao, Bin Huang, Peng Chen, Feng-Tian Jing, Xuan Jiang, Hong-Zhen Xu, Yan-Feng Tang, Li-Wei Chu, Hai-Ling Huang, Wen-Li Wang, Fang-Ning Wei, Dan-Dan Huang, Bin-Jing Zhao, Jia Chen, Hao Zhang

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Acute exacerbation chronic obstructive pulmonary disease (AECOPD); platelet-to-lymphocyte ratio (PLR); neutrophil-to-lymphocyte ratio (NLR); monocyte-to-lymphocyte ratio (MLR); baso-phil-to-lymphocyte ratio (BLR); eosinophil-to-lymphocyte ratio (ELR); in-hospital mortality; nom-ogram; decision curve analysis (DCA); clinical impact curve (CIC)

Online: 14 November 2022 (04:42:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0018.v1

Restoring Upper Limb Function by Combined Repetitive Transcranial Magnetic Stimulation and Occupational Therapy in Patients with Chronic Stroke: A Stratified Analysis Factoring the Severity of Motor Paralysis using a Multicenter Cohort Study Database

Daigo Sakamoto, Toyohiro Hamaguchi, Kai Murata, Hiroshi Ito, Yasuhide Nakayama, Masahiro Abo

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: stroke; occupational therapy; activities of daily living; goal setting; transcranial magnetic stimulation: upper extremity; motor paralysis

Online: 1 November 2022 (04:46:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0420.v1

Differential Effects of Exercise on fMRI of the Midbrain Ascending Arousal Network Nuclei in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) and Gulf War Illness (GWI) in a Model of Postexertional Malaise (PEM)

James N Baraniuk, Alison Amar, Haris Pepermintwala, Stuart D Washington

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Midbrain; postexertional malaise; PEM, arousal; exercise; fMRI; autonomic; postural tachycardia; Myalgic Encephalomyelitis / Chronic Fatigue Syndrome; ME/CFS; Gulf War Illness; GWI

Online: 23 November 2021 (10:53:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.1642.v1

Impact of First- and Second-Generation Tyrosine Kinase Inhibitors on the Development of Graft-Versus-Host Disease in Individuals with Chronic Myeloid Leukemia: A Retrospective Analysis on behalf of the Polish Adult Leukaemia Group

Ugo Giordano, Agnieszka Piekarska, Witold Prejzner, Lidia Gil, Jan Maciej Zaucha, Joanna Kujawska, Zuzanna Dybko, Krzysztof Dudek, Sebastian Giebel, Jarosław Dybko

Subject: Medicine And Pharmacology, Hematology Keywords: allogeneic hematopoietic stem cell transplantation; chronic myeloid leukaemia; tyrosine kinase inhibitors; imatinib; dasatinib; nilotinib

Online: 22 August 2024 (16:30:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0623.v1

The Reification of the Clinical Diagnosis of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) as an Immune and Oxidative Stress Disorder: Construction of a Data-Driven Nomothethic Network and Exposure of ME/CFS Subgroups

Michael Maes, Marta Kubera, Kristina Stoyanova, Jean–Claude Leunis

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: depression; neuroimmune; inflammation; oxidative and nitrosative stress; autoimmune; bacterial translocation

Online: 29 January 2021 (13:17:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202204.0296.v1

Efficacy of Short-Term High Dose Pulsed Dapsone Combination Therapy in the Treatment of Chronic Lyme Disease/Post-Treatment Lyme Disease Syndrome (PTLDS) and Associated Co-infections: A Report of Three Cases and Literature Review

Richard I. Horowitz, Phyllis R. Freeman

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: dapsone; disulfiram; chronic Lyme disease; Post-Treatment Lyme Disease Syndrome; babesia; bartonella; persisters; biofilms.

Online: 29 April 2022 (10:12:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1596.v1

Increased Frequency of Circulating Activated FOXP3+ Regulatory T-cell Subset in Patients with Chronic Lymphocytic Leukemia Is Associated with the Estimate of the Size of the Tumor Mass, STAT5 Signaling and Disease Course during Follow-Up of Patients

Zlatko Roškar, Mojca Dreisinger, Evgenija Homšak, Tadej Avčin, Sebastjan Bevc, Aleš Goropevšek

Subject: Medicine And Pharmacology, Hematology Keywords: Chronic lymphocytic leukemia (CLL); Signal Transduction; Cytokines; T Cells

Online: 21 August 2024 (16:59:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.0169.v1

A Brief Review on the Cell Culture History: From Harrison to Organs-on-a-Chip

Lincoln Gozzi Moro, Lucas Pires Guarnier, Maurício Fogaça Azevedo, Julia Amanda Rodrigues Fracasso, Marco Aurélio Lucio, Mateus Vidigal de Castro, Marlon Lemos Dias, Francislaine Aparecida dos Reis Lívero, João Tadeu Ribeiro-Paes

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Cell culture; 2D cell culture; 3D cell culture; Organoids; Spheroids; Organs-on-a-chip

Online: 3 September 2024 (07:30:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.1841.v1

A Possible Therapeutic Application of The Selective Inhibitor of Urate Transporter 1, Dotinurad, for Metabolic Syndrome, Chronic Kidney Disease, and Cardiovascular Disease: A Significance of Inhibition of Urate Transporter 1 and Non-inhibition of Other Urate Transporters for Such Diseases

Hidekatsu Yanai, Hiroki Adachi, Mariko Hakoshima, Sakura Iida, Hisayuki Katsuyama

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: ATP-binding cassette transporter G2; chronic kidney disease; dotinurad; hyperuricemia; organic anion transporter1/3; urate transporter 1

Online: 26 December 2023 (03:03:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.2464.v1

Characterization of the Aqueous Phase from Pyrolysis of Açaí Seeds and Fibers (Euterpe oleracea Mart.)

Erick Monteiro de Sousa, Kelly Christina Alves Bezerra, Renan Marcelo Pereira Silva, Gabriel Arthur da Costa Martins, Gabriel Xavier de Assis, Raise Brenda Pinheiro Ferreira, Lucas Pinto Bernar, Neyson Martins Mendonça, Carmen Gilda Barroso Tavares Dias, Douglas Alberto Rocha de Castro, Gabriel de Oliveira Rodrigues, Sergio Duvoisin Junior, Marta Chagas Monteiro, Nélio Teixeira Machado

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: Biomass wastes; Aç; aí; seeds and fibers; Chemical activation; Pyrolysis process; Characterization of aqueous phase

Online: 30 July 2024 (11:39:43 CEST)

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The açaí (Euterpe oleracea Mart.) is a native fruit of the Amazon that is well-known due to its commercial value. Its production chain is centered in the state of Pará, largely supplied by extractivism. The processing of açaí fruits in nature generates huge amount of solid waste, which can pose serious risks to the environment if not used and managed properly. Due to a small number of systhematic studies on the effect of chemical activation by pyrolysis of açaí seeds and fibers, and with the aim of providing a basis for future applications of the waste generated by processing of açaí fruits, the present work proposes a study of the pyrolysis of açaí seeds and fibers and the physicochemical and compositional characterization of the aqueous phase products. In this way, açaí seeds were collected from a local artisan processing facility in the city of Belém, PA. The seeds were dried at 105°C until constant weight, and subsequently, the fibers were separated from the seeds in a rotating drum. The seeds and fibers were impregnated with NaOH solutions at 0.5M, 1.0M, and 2.0M, and then pyrolyzed at a laboratory scale at 450 °C and 1 atm. The liquid products from pyrolysis were characterized through acidity index analysis, Fourier-transform infrared spectroscopy, and gas chromatography. The increase in the concentration of the impregnating agent resulted in an increase in bio-oil yield from both the seeds and fibers, rising from 3.3% (raw seeds) to 6.6% (seeds impregnated with 2M NaOH) and from 1.2% (raw fibers) to 3.7% (fibers impregnated with 2M NaOH). The yield in the aqueous phase after biomass pyrolysis showed an inverse behavior to the bio-oil yield, decreasing from 33.7% (raw fibers) to 21.2% (fibers impregnated with 2M NaOH) and from 41% (raw seeds) to 37.5% (seeds impregnated with 2.0M NaOH). High acidity levels were found in the aqueous phase samples and bio-oils derived from the seeds and fibers, which decreased as the concentration of the impregnating agent increased. The increase in the concentration of the impregnating agent (NaOH) influenced the chemical composition of the obtained liquid products, leading to a decrease in oxygenated compounds and an increase in nitrogenous compounds in both experimental matrices, which was also evidenced by the reduction in acidity.

Preprint REVIEW | doi:10.20944/preprints202408.1277.v1

Sedentary Life Is an Invisible Trap: Molecular, Cellular, and Systemic Reasons to Leave It Behind

Daniel Guerreiro Diniz, João Bento-Torres, Victor Oliveira Da Costa, Josilayne Patrícia Ramos Carvalho, Alessandra Mendonça Tomás, Thaís Cristina Galdino de Oliveira, Fernanda Cabral Soares, Liliane Dias e Dias de Macedo, Naina Yuki Vieira Jardim, Natáli Valim Oliver Bento-Torres, Daniel C. Anthony, Dora Brites, Cristovam Wanderley Picanço-Diniz

Subject: Biology And Life Sciences, Aging Keywords: Age-related cognitive decline; epigenetics; immunosenescence; neurodegeneration; neuron-glia crosstalk; neuroinflammation and oxidative stress; physical exercise; protein aggregation; non-pharmacological and therapeutic interventions; synaptic dysfunction

Online: 20 August 2024 (05:12:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0084.v2

Thermochemical Transformation of Municipal Household Solid Waste Fractions into Bio-Oils and Bio-Adsorbents

Higor Ribeiro Borges, Fernanda Paula da Costa Assunção, Diogo Oliveira Pereira, Lauro Henrique Hamoy Guerreiro, Simone Patrícia Aranha Da Paz, Marcelo Costa Santos, Onésimo Amorim Corrêa, Jorge Fernando Hungria Ferreira, Douglas Alberto Rocha De Castro, Isaque Wilkson De Sousa Brandão, Neyson Martins Mendonça, José Almir Rodrigues Pereira, Marta Chagas Monteiro, Sergio Duvoisin, Jr., André Oliveira Menezes, Luiz Eduardo Pizarro Borges, Nélio Teixeira Machado

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: MSW; Organic fractions of MSW, Thermochemical process; Characterization of biochar and bio-oil

Online: 16 August 2024 (17:14:02 CEST)

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This work aims to investigate the effect of process temperature and catalyst content by thermochemical degradation of municipal solid waste (MSW) fraction (organic matter + paper + plastic) on the yield of reaction products (bio-oil, biochar, H2O and gas), physi-cochemical properties and chemical composition of bio-oils, as well as on the morphol-ogy and crystalline phases of biochar in laboratory scale. The organic matter, paper and plastic segregated from the gravimetric composition of total waste sample were subject-ed to the pre-treatments of drying, crushing and sieving. Thermal pyrolysis was per-formed at 400, 450 and 475 °C and 1.0 atmosphere, and catalytic pyrolysis at 450°C and 1.0 atmosphere, using 5.0, 10.0 and 15.0% (wt.) of FCC zeolite, bath mode, using a laboratory-scale borosilicate glass reactor. The bio-oil was characterized for acidic val-ue. The chemical functions present in the bio-oil identified by FT-IR and the composi-tion by GC-MS. Biochar was characterized by SEM/EDS and XRD. Thermal pyrolysis of the MSW fraction shows bio-oil yields between 9.44 and 9.24% (wt), aqueous phase yields between 21.93 and 18.78% (wt), solid phase yields between 67.97 and 40.34% (wt) and gas yields between 28.27 and 5.92% (wt). The bio-oil yield decreased with in-creasing process temperature. For the experiments using FCC, the biochar and gas yields slightly increased with increasing FCC content, while that of bio-oil decreased and the H2O phase remained constant. GC-MS of bio-oils identified the presence of hy-drocarbons and oxygenates, as well as nitrogen-containing compounds including am-ides and amines. The acidity of the bio-oil increased with increasing temperature and with the aid of FCC as a catalyst. The presence of hydrocarbons in bio-oil was identified by the addition of FCC catalyst due to the deoxygenation of carboxylic acids, followed by decarboxylation and decarbonylation reactions, producing aliphatic and aromatic hydrocarbons.

Preprint COMMUNICATION | doi:10.20944/preprints202407.2510.v1

Cytoprotective Effect of Copaifera reticulata Ducke Oil-Resin Extracted from Amazon Flora on Neural Cells Exposed to Rotenone

Gabriel Mesquita da Conceição Bahia, Marcio Gonçalves Correa, Rebeca da Costa Gomes, Thais Alves Lobão, Rafael Dias de Souza, Elizabeth Sumi Yamada, Edmar Tavares Costa, Dielly Catrina Favacho Lopes, Arnaldo Jorge Martins-Filho, Walace Gomes-Leal, Anderson Manoel Herculano Oliveira Da-Silva, Karen Renata Herculano Matos-Oliveira, Carlomagno Pacheco Bahia

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Central nervous system injuries; Amazon; Natural extracts; Copaifera reticulata; Neurotoxicity

Online: 31 July 2024 (10:23:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1308.v1

Final Validation of the Quality of Life after Brain Injury for Children and Adolescents after Traumatic Brain Injury (QOLIBRI-KID/ADO) Questionnaire

Nicole von Steinbuechel, Marina Zeldovich, Dagmar Timmermann, Ugne Krenz, Inga K. Koerte, Michaela V. Bonfert, Steffen Berweck, Matthias Kieslich, Marlene Henrich, Knut Brockmann, Anna Buchheim, Maike Roediger, Michael Lendt, Christian Auer, Axel Neu, Alexander Kaiser, Joenna Driemeyer, Sven Greving, Ulrike Wartemann, Daniel Pinggera, Claudius Thome, Joachim Suss, Holger Muehlan, Katrin Cunitz

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: health-related quality of life (HRQoL); pediatric traumatic brain injury (TBI); QOLIBRI-KID/ADO

Online: 22 February 2024 (13:22:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.0184.v1

Effect of Temperature and Molarity on the Evaluation of Antimicrobial, Cytotoxic, and Antioxidant Activities of the Bio-Oil from Açaí Seed (Euterpe oleracea, Mart.)

Iago Castro da Silva, Pamela Suelen da Silva Seabra, Kely Campos Navegantes Lima, Ricardo Barbosa Bezerra Filho, Alanna Lorena P. dos Santos, Amanda Caroline dos Santos Monteiro, Giovanna Quintero Pamplona, Alexandre Guilherme da Silva Dias, Rayane Caroline dos Santos Pereira, Leticia Araujo Costa, Thays Jhessica Mota Pinheiro, Lauro Henrique Hamoy Guerreiro, Nélio Teixeira Machado, Marta Chagas Monteiro

Subject: Medicine And Pharmacology, Pharmacy Keywords: Açaí; Bio-oil; Pyrolysis

Online: 2 August 2024 (16:44:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1142.v1

Effect of Virtual Reality Technology in Table Tennis Teaching: A Multi-Center Controlled Study

Tingyu Ma, Wenhao Du, Qiufen Zhang

Subject: Artificial Intelligence And Machine Learning, Computer Science And Mathematics Keywords: virtual reality; table tennis; sports education; skill acquisition; learning motivation; training effectiveness

Online: 18 September 2024 (02:26:36 CEST)

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Preprint INTERESTING IMAGES | doi:10.20944/preprints202409.1138.v1

Reflectance Confocal Microscopy Can Help in Detecting Clinically Silent Mammary Paget Disease: A Case Report

Carmen Cantisani, Alberto Taliano, Caterina Longo, Stefano Astorino, Vito V Gomes, Gianluca Caruso, Suppa Mariano, Stefania Guida, Anna Pogorzelska-Antkowiak, Giovanni Pellacani

Subject: Dermatology, Medicine And Pharmacology Keywords: Dermoscopy-Mammary Paget disease; reflectance confocal microscopy

Online: 18 September 2024 (02:21:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1145.v1

Comparing Strategies and Success of Policy Entrepreneurs in EU Energy and Climate Policy Processes

Fredrik von Malmborg

Subject: Political Science, Social Sciences Keywords: Climate policy; comparative analysis; European Union; policy entrepreneurs; policy entrepreneurship; strategies

Online: 18 September 2024 (02:16:31 CEST)

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BackgroundThe clean energy transition required for decarbonisation of our societies make policymakers targets for broad business and non-business advocacy to ensure one’s often conflicting interests are protected or taken into consideration in public policies. The concept of policy entrepreneurs foregrounds the role of agency in understanding such acts of advocacy. This paper compares strategies used by policy entrepreneurs from different social spheres, advocating policy change or status quo, in four longitudinal cases related to European Union energy and climate policy 2011–2023. ResultsPolicy entrepreneurship was mainly of a cultural-institutional nature, aiming at altering or diffusing people’s perceptions, beliefs, norms and cognitive frameworks, worldviews, or institutional logics. But the actions of the European Commission did also include structural entrepreneurship, aiming at overcoming structural barriers to enhance governance influence by altering the distribution of formal authority and factual and scientific information. Motifs of policy entrepreneurs in the four cases differ, but strategies do not differ significantly between the public, private and civic spheres of society. Results indicate that civil society policy entrepreneurs focus on building broader coalitions than public and private sector entrepreneurs. There is no indication that policy entrepreneurs from a certain sector would be more successful than others in setting the agenda, changing perceptions of policy actors, or influencing actual policy change. However, policy entrepreneurs advocating policy change are more active and use more elaborated strategies than policy entrepreneurs advocating status quo. ConclusionsIt is concluded that policy entrepreneurs advocating policy change are more active and use more elaborated strategies than policy entrepreneurs advocating status quo. Thus, they are more successful in influencing policy outcomes. The European Commission was the only policy entrepreneurs to use structural entrepreneurship. the Commission acts to expand its reach into areas where the European Union does not hold much legal competence according to the constitution of the European Union. This comes with democratic deficits related to accountability and legitimacy and should be combated to reinstate and reinforce the position and powers of both the national and European legislators in taking the important decisions that impact the lives of European citizens.

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