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Preprint ARTICLE | doi:10.20944/preprints201810.0448.v1

MERTK rs4374383 Polymorphism Predicts Progression of Liver Fibrosis in HCV-Infected Patients: A Longitudinal Study

Maria Angeles Jimenez-Sousa, Ana Zaida Gómez-Moreno, Daniel Pineda-Tenor, Oscar Brochado-Kith, Juan José Sánchez-Ruano, Tomás Artaza-Varasa, Alicia Gómez-Sanz, Amanda Fernández-Rodríguez, Salvador Resino

Subject: Biology And Life Sciences, Virology Keywords: liver stiffness; MERTK; chronic hepatitis C; cirrhosis; SNPs

Online: 19 October 2018 (10:56:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0392.v1

Amani Zidan, Ahmed Awaisu, Maguy El-Hajj, Samya Al-Abdulla, Dianne Figueroa, Nadir Kheir

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Medication-related burden; Questionnaire; chronic disease conditions; adherence

Online: 25 June 2018 (14:35:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints201805.0396.v1

Smart Wound Dressings for Diabetic Chronic Wounds

Elizabeth Gianino, Craig Miller, Jordon Gilmore

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: diabetes; chronic wounds; smart wound dressing; biochemical sensor

Online: 28 May 2018 (10:22:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201802.0137.v1

Burden of Serious Fungal Diseases in Romania

Mihai Mareș, Valentina Ruxandra Moroti-Constantinescu, David W. Denning

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: mycoses; epidemiology; Romania; candidaemia; aspergillosis; chronic pulmonary conditions

Online: 21 February 2018 (16:41:29 CET)

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Objective: To estimate for the first time the burden of serious fungal infections in Romania; Methods: Data derived from the World Health Organization (WHO), National Institute of Statistics, Romanian public health agencies and non-profit health organizations and published annual reports on local epidemiology were used in the present study. When no data was available, specific at-risk populations were used to calculate frequencies of serious fungal diseases, using previously published epidemiological parameters. All data refer to the year 2016; 3) Results: The estimated number of serious fungal infections in Romanian population was 435,930 in 2016. Recurrent vulvovaginal candidiasis accounts for up to 80% of total cases (more than 350,000 women annually). Concerning the HIV related infections, among 14349 infected persons, Pneumocystis pneumonia occurred in about 10% of late presenters (30 cases in 2016), while cryptococcal meningitis is rarely diagnosed (less than 20 cases). Annually, the total number of oesophageal candidiasis and oral thrush cases in HIV-positive patients may be as high as 1229 and 3066, respectively. In immunocompromised and cancer patient population, the annual incidence of candidaemia is 295, and at least 158 invasive aspergillosis cases and 4 mucormycosis cases occur yearly. With 4,966 critical care beds and approximately 200,000 abdominal surgeries performed, the estimated annual incidence of candidaemia and Candida peritonitis is 689 and 344, respectively. The annual incidence of pulmonary tuberculosis is still high in Romania (12,747 cases). Thus, the prevalence of post-TB chronic pulmonary aspergillosis is estimated to be 8.98/100,000 (1768 cases). The prevalence of chronic obstructive pulmonary disease (COPD) and asthma in adults is 6% and 6.5%, respectively. Therefore, allergic bronchopulmonary aspergillosis prevalence is estimated at 29,387 and severe asthma with fungal sensitisation at 38,731 cases annually. 4) Conclusions: Not being on the list of reportable diseases, the number of patients presenting with severe mycoses in Romania can only be roughly estimated. Based on local reports and prevalence estimation, we consider that at least 2.2% of Romanians suffer a serious form of fungal disease.

Preprint REVIEW | doi:10.20944/preprints201709.0146.v2

Role of LFA-1 and ICAM-1 in Cancer

Manuel Reina, Enric Espel

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: cancer metastasis; chronic lymphocytic leukemia; exosomes; tumor microenvironment

Online: 29 September 2017 (03:17:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0220.v1

Service Innovations in Health Care Service Ecosystem: A Case Study

Maria Vincenza Ciasullo, Silvia Cosimato

Subject: Business, Economics And Management, Business And Management Keywords: innovation; service innovation; healthcare; chronic diseases; SD Logic

Online: 30 March 2017 (17:10:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0416.v1

Chronic Diseases Associated with Malassezia Yeast

Abdourahim Abdillah, Stéphane Ranque

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Malassezia; Chronic diseases; psoriasis; atopic dermatitis; chronic rhinosinusitis; asthma; cystic fibrosis; HIV infection; inflammatory bowel disease; colorectal cancer; neurodegenerative diseases

Online: 24 September 2021 (08:13:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0527.v1

Finite Mixture Models Based on Pain Intensity, Functional Disability and Psychological Distress Composite Assessment Allow to Identify Two Distinct Classes of Persistent Spinal Pain Syndrome after Surgery Patients Related to Their Quality of Life

Amine Ounajim, Maxime Billot, Pierre-Yves Louis, Yousri Slaoui, Denis Frasca, Lisa Goudman, Manuel Roulaud, Nicolas Naiditch, Bertille Lorgeoux, Sandrine Baron, Kevin Nivole, Mathilde Many, Nihel Adjali, Philippe Page, Bénédicte Bouche, Elodie Charrier, Laure Poupin, Delphine Rannou, Géraldine Brumauld de Montgazon, Brigitte Roy-Moreau, Chantal H. Wood, Raphael Rigoard, Romain David, Maarten Moens, Philippe Rigoard

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: PSPS; FBSS; chronic pain; health-related quality of life; mixture models analysis; personalized pain management; chronic pain after spinal surgery

Online: 27 August 2021 (15:23:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0392.v1

Incorporating Point-of-Care Bacterial Fluorescence into a Wound Clinic Antimicrobial Stewardship Program

Thomas Serena

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: antimicrobial stewardship; detection of bacteria in chronic wounds, chronic wounds, clinical decision support; diagnostic pathway; joint commission; fluorescence imaging; wound clinic

Online: 19 October 2020 (15:35:25 CEST)

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Background: In 2014 the World Health Organization (WHO) warned of an emerging world-wide crisis of antibiotic resistant microorganisms. In response, government and professional organizations recommended that health care systems adopt antimicrobial stewardship programs (ASPs). In the United States, the Centers for Medicare Services (CMS) mandated antimicrobial stewardship in the hospital inpatient setting. Effective January 1, 2020, the Joint Commission required ambulatory centers that prescribe antibiotics, such as wound centers, to institute an ASP. Chronic wounds often remain open for months, during which time patients may receive multiple courses of antibiotics and numerous antimicrobial topical treatments. The wound clinician plays an integral role in reducing antimicrobial resistance in the outpatient setting: antibiotics prescribed for skin and soft tissue infections are among the most common in an outpatient setting. One of the most challenging aspects of antimicrobial stewardship in treating chronic wounds is the inaccuracy of bacterial and infection diagnosis. Methods: Joint Commission lists five elements of performance (EP): (1) Identifying an antimicrobial stewardship leader, (2) establishing an annual antimicrobial stewardship goal, (3) implementing evidence-based practice guidelines related to the antimicrobial stewardship goal, (4) providing clinical staff with educational resources related to the antimicrobial stewardship goal, and (5) collecting, analyzing, and reporting data related to the antimicrobial stewardship goal. This article focuses on choosing and implementing an evidence-based ASP goal for 2020. Discussion: Clinical trials have demonstrated the ability of fluorescence imaging (MLiX) to detect clinically significant levels of bacteria in chronic wounds. Combined with clinical examination of signs and symptoms of infection, the MLiX procedure improves the clinician’s ability to diagnose infection and can guide antimicrobial use. In order to satisfy the elements of performance, the MLiX procedure was incorporated into the annual ASP goal for several wound care centers. Clinicians were educated on the fluorescence imaging device and guidelines were instituted. Collection of antimicrobial utilization data is underway.

Preprint ARTICLE | doi:10.20944/preprints202411.0605.v1

Transfusion Requirements for Severe Anemia in Acute Cardiovascular Patients—A Single Center Retrospective Study in Constanta County Cardiology Department

Sevigean Ali, Iulia Andreea Badea, Mihaela Botnarciuc, Liliana-Ana Tuta, Lavinia Carmen Daba, Andreea Alexandru, Raluca Irinel Parepa, Alina- Mihaela Stanigut, Mihaela Ionescu

Subject: Cardiac And Cardiovascular Systems, Medicine And Pharmacology Keywords: Anemia; blood transfusions; heart failure; chronic kidney disease; mortality

Online: 8 November 2024 (08:49:04 CET)

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Anemia is common in hospitalized cardiac patients and affects prognosis. Even moderate levels of anemia can be associated with high cardiovascular mortality when compared to normal hemoglobin levels in cases of patients with acute decompensated heart failure. Background: Anemia is a comorbidity potentially treatable, with significant prognostic implications. A restrictive transfusion is triggered by hemoglobin is ≤8g/dl (severe anemia) and a liberal transfusion is considered when hemoglobin ≤10 g/dL. Methods: We perform a retrospective analysis of the patients hospitalized in the Cardiology Department of Constanta County Hospital who required blood derivatives transfusions, between 1st of January 2021 - 31st of December 2021. Results: Out of the total 270 patients, 170 received a single unit of resuspended erythrocyte concentrate within the same month, while 100 required multiple transfusions, receiving between 2 and 5 units during a single hospitalization to correct anemia. Before transfusions, the mean hemoglobin (Hb) level was 7.60 g/dl, with values ranging from 6.50 g/dl to 9.10 g/dl. Men show a higher prevalence (64%) than women (36%), likely due to gender differences in susceptibility to heart conditions. After transfusions, the mean Hb reached 10.05 g/dl (minimum/maximum values of 7.40 and 12.70 g/dl). CKD patients consistently experience higher in-hospital mortality across LVEF sub-groups, while CRS patients have relatively lower mortality rates, with significant associations observed between reduced LVEF and increased mortality across all patient groups. Conclusions: Anemia in heart failure patients is linked to worsening symptoms, including decreased exercise tolerance, increased cardiovascular events, decreased kidney function and higher hospitalization and mortality rates, especially in those with associated acute or chronic kidney failure. The findings aim to inform and optimize clinical decision making, particularly regarding transfusion strategies and risk management in this high-risk population.

Preprint REVIEW | doi:10.20944/preprints202410.2399.v1

Aberrances of the Wound Healing Process: A Review

Montserrat Fernandez-Guarino, Jorge Naharro-Rodriguez, and Stefano Bacci

Subject: Biology And Life Sciences, Life Sciences Keywords: wound healing; acute wounds; chronic wounds; keloids; hyperthrofic scars

Online: 30 October 2024 (07:34:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202410.0672.v2

Role of S1P Signaling Pathway in Pancreatic Diseases

Fei Fu, Wanmeng Li, Xiaoyin Zheng, Yaling Wu, Dan Du, Chenxia Han

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: S1P; SPHKs; S1PRs; acute pancreatitis; chronic pancreatitis; pancreatic cancer

Online: 11 October 2024 (04:33:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.0398.v1

Prognostic Significance and Treatment Response Associations of Genetic Mutations in Chronic Myelomonocytic Leukemia: A Retrospective Cohort Study

Jing Di, Leonard N Yenwongfai, Talal Arshad, Bin Huang, Jaclyn K. McDowell, Eric B Durbin, Reinhold Munker, Sainan Wei

Subject: Medicine And Pharmacology, Hematology Keywords: chronic myelomonocytic leukemia; genetic profiling; prognostic biomarkers; survival analysis

Online: 7 October 2024 (07:58:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202410.0051.v1

Research Progress on Using Inorganic Nanomaterials to Enhance the Efficacy of Drug Therapy for Chronic Mountain Sickness

Boshen Liang, Yang Zhou, Yuliang Qin, Xinyao Li, Sitong Zhou, Kai Yuan, Rong Zhao, Xiaoman Lv, Dongdong Qin

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Keywords: chronic mountain sickness; nanomaterials drug delivery; targeted therapy

Online: 1 October 2024 (11:38:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1519.v1

Chronic Rheumatologic Disease in Chikungunya Virus Fever: Results from a Cohort Study Conducted in Piedecuesta, Colombia

Anyela Lozano-Parra, Víctor Herrera, Carlos Calderón, Reynaldo Badillo, Rosa Margarita Gélvez Ramírez, María Isabel Estupiñán Cárdenas, José Fernando Lozano Jiménez, Luis Ángel Villar, Elsa Marina Rojas Garrido

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Chikungunya; chronic rheumatism; rheumatic disease; fatigue; quality of life

Online: 19 September 2024 (12:21:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0967.v1

Visual Evoked Potentials Sensitization/Habituation Mechanisms in Chronic Migraine Patients with or without Medication Overuse

Gianluca Coppola, Francesco Casillo, Gabriele Sebastianelli, Chiara Abagnale, Cherubino Di Lorenzo, Antonio Di Renzo, Mariano Serrao, Vincenzo Parisi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Medication overuse; chronic migraine; visual cortex; amplitude; medication withdrawal

Online: 12 September 2024 (17:49:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0828.v1

Development and Validation of the Short form of the Joint Assessment of Equilibrium and Neuromotor Status Scale (JAEN-10)

Ana Belén Peinado-Rubia, María Catalina Osuna-Pérez, David Núñez-Fuentes, Daniel Rodríguez-Almagro, Noelia Zagalaz-Anula, Rafael Lomas-Vega

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: balance control; chronic fatigue syndrome; disability evaluation; dizziness; fibromyalgia

Online: 11 September 2024 (04:24:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.0272.v1

Relationship between Sleep Disturbances and Chronic Pain: A Narrative Review

Sejal V Jain, Geoffrey D Panjeton, Yuri Chaves Martins

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: bidirectional relationship; chronic pain; polysomnography; sleep disorders; sleep disturbances

Online: 5 September 2024 (06:05:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.1772.v6

Treating Anxiety-Based Cognitive Distortions Pertaining to Somatic Perception for Better Chronic Pain Outcomes: A Recommendation for Better Practice in the Present Day and the Cyber Age of Medicine

Marcelina Jasmine Silva

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: chronic pain; catastrophizing; fear avoidance; kinesiophobia; opioids; anxiety; depression; artificial intelligence

Online: 8 October 2024 (11:58:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1596.v1

Increased Frequency of Circulating Activated FOXP3+ Regulatory T-cell Subset in Patients with Chronic Lymphocytic Leukemia Is Associated with the Estimate of the Size of the Tumor Mass, STAT5 Signaling and Disease Course during Follow-Up of Patients

Zlatko Roškar, Mojca Dreisinger, Evgenija Homšak, Tadej Avčin, Sebastjan Bevc, Aleš Goropevšek

Subject: Medicine And Pharmacology, Hematology Keywords: Chronic lymphocytic leukemia (CLL); Signal Transduction; Cytokines; T Cells

Online: 21 August 2024 (16:59:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1421.v1

Changes in Skeletal Muscle Atrophy over Time in a Rat Model of Adenine-Induced Chronic Kidney Disease

Kento Okamoto, Yuji Kasukawa, Koji Nozaka, Hiroyuki Tsuchie, Daisuke Kudo, Hayato Kinoshita, Yuichi Ono, Shun Igarashi, Fumihito Kasama, Shuntaro Harata, Keita Oya, Takashi Kawaragi, Kenta Tominaga, Manabu Watanabe, Naohisa Miyakoshi

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: chronic kidney disease; sarcopenia; animal model; muscle atrophy; mitochondria

Online: 20 August 2024 (09:54:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0050.v1

Effects of Continuous Prenatal Low Dose Rate Irradiation on Neurobehavior, Hippocampal Cellularity, mRNA and miRNA Expression on B6C3F1 Mice

FengRu Tang, Ignacia Braga Tanaka, Hong Wang, Salihah Lau, Satoshi Tanaka, Amanda Tan, Daisaku Takai, Akiko Abe

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Prenatal; low dose rate; chronic radiation exposure; brain effect

Online: 1 August 2024 (15:28:15 CEST)

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Abstract: Epidemiological, experimental, and ecological data have indicated the controversial effect of in utero chronic low dose rate (100 mGy) dose radiation exposure. Our main goal of this study was to examine if different low dose rates of chronic pre- or/and post-natal radiation exposure with accumulative high doses could induce hippocampal cellular, mRNA, and miRNA changes leading to neuropsychiatric disorders. The comprehensive mouse phenotypic traits, organ weight pathological, blood mRNA and miRNA changes were also studied. Using different approaches including SmithKline, Harwell, Imperial College, Royal Hospital, Phenotype Assessment (SHIRPA), neurobehavioral tests, pathological examination, immunohistochemistry, mRNA and miRNA sequencing, and real-time quantitative polymerase chain reaction ( qRT-PCR) validation, we found that in prenatally irradiated (100 mGy/d for 18 days with an accumulative dose of 1.8 Gy) 1-year-old mice, no cellular changes including neurogenesis, mature neurons and glial cells in the hilus of the dentate gyrus and development of cognitive impairment, neuropsychiatric disorders occurred. However, a significant reduction in body weight and mass index (BMI) was indicated by the SHIRPA test. A reduced exploratory behavior was shown by an open field test. Organ weight measurement showed a significant reduction of the testes, kidneys, heart, liver, and epididymides although no abnormal changes from pathological examination. mRNA and miRNA sequencing and qRT-PCR validation revealed the upregulation of Rubcnl, Abhd14b and downregulation of Hspa1b, P4ha1, and Banp genes in both hippocampus and blood of mice prenatally irradiated with 100 mGy/d. Meanwhile, downregulation of miR-448-3p, miR1298-5p in the hippocampus, miR-320-3p, miR-423-5p, miR-486b-5p, miR-486b-3p, miR-423-3p, miR-652-3p, miR-324-3p, miR-181b-5p, miR-let-7b and miR-6904-5p in the blood was induced. The target scan revealed that Rubcnl is one of the miR-181b-5p targets in the blood. We, therefore, concluded that prenatal chronic irradiation with a low dose rate of 100 mGy/d and accumulative dose of 1.8Gy or below may not induce significant adverse health effects on the offspring. Further study of different low dose rate radiation exposure with accumulative high doses may provide threshold doses for authorities or regulators to set new radiation safety guidelines to replace those extrapolated from acute high dose/dose rate irradiation to reduce unnecessary emergency evacuation or expanding once a nuclear accident or leakage occurs.

Preprint ARTICLE | doi:10.20944/preprints202407.2562.v1

Comparative Analysis of the Effect of Beta Blockers of Different Generations on the Parameters of Myocardial Energy Metabolism in Experimental Doxorubicin-Induced Chronic Heart Failure

Igor Belenichev, Olexiy Goncharov, Nina Bukhtiyarova, Oleh Kuchkovskyi, Victor Ryzhenko, Lyudmyla Makyeyeva, Valentyn Oksenych, Oleksandr Kamyshnyi

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: chronic heart failure; beta blockers; energy metabolism; mitochondria; Hypertril

Online: 31 July 2024 (12:36:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1738.v1

Novel Insight into the Effect of Balneotherapy on Changes in the Functional State in Patients with Chronic Low Back Pain: Integration of Physical and Mental Healthcare Indicators and Patients’ Health Perception

Dragana Terzic Markovic, Sanja Kocic, Jovana Bradic, Aleksandra Jurisic Skevin, Biljana Jakovljevic, Biljana Majstorovic, Zvonko Dimoski, Goran Stojanovic, Vesna Maksimovic, Katarina Pavlovic Jugovic, Marijana Dabic, Danijela Jezdimirovic, Sandra Zivanovic

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: chronic low back pain; balneotherapy; functionality; life quality; pain

Online: 23 July 2024 (07:40:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1478.v1

Contribution of echocardiography and 2D strain in the detection of subtle myocardial involvement in group A and B patients with chronic obstructive pulmonary disease

Rania Kaddoussi, Ikram Chamtouri, Wafa Dhouib, Elassoufi Fatima ezzahra, Monia Daami, Walid Jomaa, Wissal Rouetbi, Khaldoun Ben Hamda

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: chronic obstructive pulmonary disease; subtle myocardial involvement; echocardiography; strain

Online: 18 July 2024 (09:35:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0998.v1

The Dietary Conundrum in Dialysis Patients: Fact vs Fiction on Social Media

Sayani Ghosh

Subject: Biology And Life Sciences, Food Science And Technology Keywords: CKD; Chronic Kidney Dieases; Dietary Recommendations on Social Media

Online: 15 July 2024 (15:34:12 CEST)

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Background:Patients with chronic kidney disease (CKD), especially those undergoing dialysis, encounter complex nutritional challenges. Key dietary factors such as protein and fluid intake, potassium and sodium levels, and co-morbidities significantly influence dietary planning for CKD patients. A standardized approach to dietary recommendations for CKD patients is ineffective due to the diverse needs of individual patients. Social media platforms have become a popular source of dietary information, often advocating low-carb, high-protein diets, and other combinations purported to be universally beneficial. However, these generalized online dietary recommendations lack the individualized approach necessary for CKD patients. Unlike these social media-driven suggestions, established medical guidelines offer a more nuanced view of CKD dietary needs. This study investigates the discrepancies between these sources and their potential impact on patient health. Objective:The primary goal of this study is to identify and analyze the flaws in the dietary recommendation system for CKD patients that might adversely affect their health. By critically evaluating the content of YouTube videos, we aim to compare the dietary advice provided by social media influencers and content creators with established medical guidelines. Our approach combines qualitative and quantitative methods to thoroughly assess the accuracy and reliability of online dietary advice available to CKD patients. Method:We conducted four YouTube searches using keywords related to "diet plan" and "chronic kidney disease (CKD)." From each search, the first 30 videos were selected based on relevance, resulting in an initial pool of 120 videos. A stepwise screening process was used to filter out the most relevant and accessible content, ultimately narrowing the sample to 30 videos for in-depth analysis. The videos were evaluated using two scoring systems: the Journal of the American Medical Association (JAMA) score and the Global Quality Scale (GQS) score, which assess video quality. To ensure impartiality, three independent scorers conducted the evaluations. Additionally, two six-point scorecards were used to evaluate the inclusion and accuracy of information on various foods and eating behaviors affecting CKD risk, with higher scores indicating more comprehensive coverage. Data on video characteristics, such as view count, number of likes, and video age, were also collected to provide context and further insight into their reach and influence. Results:The study included 30 videos, with 60% (18 out of 30) posted by or featuring nephrology health professionals. Scorer 1 reported a mean JAMA score of 2.3 (SD 0.61) out of 4 points and a mean GQS score of 2.5 (SD 0.64) out of 5 points. Scorer 2 found a mean JAMA score of 2.5 (SD 0.62) and a mean GQS score of 2.8 (SD 0.73). Scorer 3 reported a mean JAMA score of 2.6 (SD 0.55) and a mean GQS score of 2.8 (SD 0.69). The dietary six-point scorecards revealed a mean score of 3.6 (SD 0.85) for the presence of information and 2.8 (SD 0.88) for the accuracy of the information. Conclusion:The videos analyzed in this study related to diet plans for CKD patients demonstrated generally low scores, indicating a lack of comprehensive and accurate information. Many videos provided incomplete or partial information, which could mislead viewers and potentially cause harm due to incomplete knowledge. This study highlights the need for careful scrutiny of online content, particularly on platforms like YouTube, due to the potential for contradictory information and its harmful consequences. The findings emphasize the necessity for greater accuracy and vigilance in disseminating health-related information to ensure the safety and well-being of CKD patients.

Preprint ARTICLE | doi:10.20944/preprints202407.1125.v1

Predictive Analysis of Osteoarthritis and Chronic Pancreatitis Comorbidity: Complications and Risk Factors

Iryna Halabitska, Liliia Babinets, Valentyn Oksenych, Oleksandr Kamyshnyi

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: osteoarthritis; chronic pancreatitis; comorbidity; complications; risk factors; predictors.; pancreatitis

Online: 15 July 2024 (10:26:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1134.v1

The Evil Twins of Chronic Pelvic Pain Syndrome: a systematic review and meta-analysis on Interstitial Cystitis/Bladder Pain Syndrome and Endometriosis

Inzoli Alessandra, Barba Marta, Carazita Valeria, Cola Alice, Fantauzzi Martina, Passoni Paolo, Polizzi Serena, Frigerio Matteo

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: endometriosis; chronic pelvic pain; interstitial cystitis / bladder pain syndrome

Online: 15 July 2024 (08:11:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.2048.v1

Importance of Topographical Recognition of Pulmonary Arteries in Diagnostics and Treatment of CTEPH, Based on Analysis of a Dissected Case Model – Pilot Study

Matiss Zicans, Dzintra Kazoka, Mara Pilmane, Andris Skride

Subject: Medicine And Pharmacology, Anatomy And Physiology Keywords: pulmonary arteries; anatomy; dissection; chronic thromboembolic pulmonary hypertension; angiogram

Online: 29 June 2024 (06:02:24 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202405.2167.v1

Adult-Onset Systemic Chronic Active Epstein - Barr virus Disease: A Case Report Highlighting Unique Immunophenotype and Novel Molecular Insights in the Context of Chronic HBV Hepatitis

Tulasi Geevar, Peter JB Sabatini, Tong Zhang, Ali Sakhdari

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: chronic EBV infection; T cell lymphoproliferative disorder; mutational profile

Online: 3 June 2024 (07:58:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1776.v1

CD Markers and HLA Expression in Chronic Lymphocytic Leukemia Patients: correlations and clinical relevance

Maria Tizu, Bogdan Calenic, Alexandra-Elena Constantinescu, Alexandru Adrian Bratei, Razvan Antonio Stoia, MIhnea Catalin-Gabriel Popa, Ileana Constantinescu

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Chronic lymphocytic leukemia; cluster of differentiation; human leukocyte antigen

Online: 27 May 2024 (14:27:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1519.v1

Consumption of Ultra-Processed Foods Is Associated with Abdominal Obesity in Individuals on Hemodialysis

Sara Jarske Gering, Cleodice Alves Martins, Nina Mara Paterlini Marques, Monica Cattafesta, Alexandre Cardoso da Cunha, Fabíola Lacerda Pires Soares, Edson Theodoro dos Santos Neto, Luciane Bresciani Salaroli

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Diet. Nutrition. Central obesity. Visceral obesity. Chronic kidney disease.

Online: 23 May 2024 (09:56:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0142.v1

Dynamic Interrelations between Sensory and Affective Aspects of Pain in Patients with Chronic Pain

Tatyana Telbizova

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: chronic pain; depressive episode; state and trait anxiety, correlations

Online: 3 May 2024 (04:06:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1629.v1

Burr Hole Craniostomy Versus Craniotomy for Chronic Subdural Hematoma – A Multicenter Study

Nenad Koruga, Djula Djilvesi, Anamarija Soldo Koruga, Vjekoslav Kopačin, Tatjana Rotim, Tajana Turk, Slavko Čičak, Josip Kocur, Marija Perić, Tomislav Ištvanić, Vedran Farkaš, Sonja Škiljić, Alen Rončević

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Burr hole craniostomy; Craniotomy; Chronic subdural Hematoma; Multicenter study

Online: 25 April 2024 (08:38:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0468.v1

Neuromodulation and Habituation: A Literature Review and Conceptional Analysis of Sustaining Therapeutic Efficacy and Mitigating Habituation

Anand S. Patil, Brittni Levasseur, Mayank Gupta

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: spinal cord stimulator; neuromodulation; explant; chronic pain; waveform; habituation

Online: 7 April 2024 (10:09:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.1436.v1

Cognitive Impairment and Brain Atrophy in Patients with Non-Dialysis and Dialysis Dependent Chronic Kidney Disease

Kazuhiko Tsuruya, Hisako Yoshida

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: brain atrophy; cognitive impairment; chronic kidney disease; dialysis; exercise

Online: 18 January 2024 (15:58:37 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0238.v1

Role of Obesity and Mediators of Adipose Tissue in Renal Transplant and Disease

Sonia Mota-Zamorano, Guadalupe García-Pino, Guillermo Gervasini

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: chronic kidney disease; renal transplant; arachidonic acid; adipose tissue

Online: 3 January 2024 (09:58:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1769.v1

Investigating the Efficacy of Kidney-Protective Lactobacillus Mixture-Containing pet Treats in Feline Chronic Kidney Disease and Its Possible Mechanism

Ching-Wen Tsai, Hsiao-Wen Huang, Ya-Jane Lee, Tsu-Cheng Hsu, Ming-Ju Chen

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: chronic kidney disease; gut microbiota; Lm pet treats; feline

Online: 25 December 2023 (11:19:46 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.1329.v1

A Review about Lateral Ankle Instability and Emerging Alternative Outcome Monitoring Tools in Patients Following Ankle Ligament Reconstruction Surgery

Ibrahim Saliba, Alexandre Hardy, Wenzheng Wang, Raphael Vialle, Sylvain Feruglio

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: ankle instability; chronic ankle instability; postoperative management; diagnostics; NIRS

Online: 18 December 2023 (12:45:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1964.v1

Exploring Machine Learning Algorithms-Aid Diagnosis for Chronic Kidney Disease

Omar García-González, Ivan E. Villalon-Turrubiates, Luis E Chávez-Camarena, Carlos Hernández-Mejía

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: chronic kidney disease; algorithms-aid diagnostic; machine learning algorithms

Online: 30 November 2023 (10:10:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0113.v1

Neurosecretory Protein GM-Expressing Neurons Participate in Lipid Storage and Inflammation in Newly Developed Cre Driver Mice

Yuki Narimatsu, Masaki Kato, Eiko Iwakoshi-Ukena, Shogo Moriwaki, Ayano Ogasawara, Megumi Furumitsu, Kazuyoshi Ukena

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: neurosecretory protein GM; hypothalamus; neuropeptide; obesity; chronic inflammation; chemogenetics

Online: 2 November 2023 (07:43:58 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.0374.v1

A Manifesto in Defense of Pain Complexity: A Critical Review of Essential Insights in Pain Neuroscience

Javier Picañol Párraga, Aida Castellanos Esparraguera

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: pain; chronic pain; nociception; sensory neuron; pain neuroscience education

Online: 9 October 2023 (09:31:37 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202309.1533.v1

Germline CSF3R Variant in Chronic Myelomonocytic Leukemia: Linking Genetic Predisposition to Uncommon Hemorrhagic Symptoms

Maria Teresa Bochicchio, Giorgia Micucci, Silvia Asioli, Martina Ghetti, Giorgia Simonetti, Alessandro Lucchesi

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: chronic myelomonocytic leukemia; CSF3R; bleeding disorders; predisposing genes; NGS

Online: 22 September 2023 (08:35:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0102.v1

Comparison of Surgical Risk Scores in a European Cohort of Patients with Advanced Chronic Liver Disease

Lidia Canillas, Amalia Pelegrina, Elena Colominas-González, Aina Salis, Cesar J. Enríquez-Rodríguez, Xavier Duran, Antonia Caro, Juan Álvarez, Jose A Carrión

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Cirrhosis; Advanced Chronic Liver Disease; Surgery; Postoperative risk; Mortality

Online: 4 September 2023 (07:24:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.1452.v1

Application of bioelectrical impedance analysis in nutritional management of patients with chronic kidney disease

Yanchao Guo, Meng Zhang, Ting Ye, Zhixiang Wang, Ying Yao

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: body composition; bioelectrical impedance analysis; chronic kidney disease; nutrition

Online: 21 August 2023 (09:57:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1270.v1

Estimation of the Cadmium Nephrotoxicity Threshold from Loss of GFR and Albuminuria

Soisungwan Satarug, David A. Vesey, Tanaporn Khamphaya, Phisit Pouyfung, Glenda C. Gobe, Supabhorn Yimthiang

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: albuminuria; blood pressure; cadmium; chronic kidney disease; estimated GFR

Online: 17 August 2023 (08:07:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1869.v1

The Roles of MicroRNAs in Obesity: Emphasizing Links with Chronic Kidney Disease and Cardiovascular Disorders

Valérie Metzinger-Le Meuth, Laurent Metzinger

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: RNA; obesity; chronic kidney disease; cardiovascular disorder; gene regulation

Online: 27 June 2023 (10:45:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0902.v1

Mucosal Metabolomic Signatures in Chronic Colitis: Novel Insights into the Pathophysiology of Inflammatory Bowel Disease

Nathan Calzadilla, Aisha Qazi, Anchal Sharma, Kai Mongan, Shane Comiskey, Jahnavi Manne, Alvin G. Youkhana, Sonam Khanna, Seema Saksena, Pradeep K. Dudeja, Waddah A. Alrefai, Ravinder K. Gill

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: chronic colitis; mucosal inflammation; host-microbe interactions; mucosal metabolomics

Online: 13 June 2023 (08:39:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0843.v2

Zanubrutinib: Coming of Age for BTK Inhibitors in the Treatment of Chronic Lymphocytic Leukemia?

Stefano Molica, Constantine Tam, David Allsup, Aaron Polliack

Subject: Medicine And Pharmacology, Hematology Keywords: CLL, Zanubrutinib, BTK inhibitors, efficacy, safety, chronic lymphocytic leukemia

Online: 22 May 2023 (16:15:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0475.v2

Liver Fibrosis in Individuals with Hepatitis C Virus Genotype 1B from Brazilian Eastern Amazon

Tatiane Lobato Da Silva, Apio Ricardo Nazareth Dias, Juarez Antônio Simões Quaresma, Luiz Fábio Magno Falcão

Subject: Biology And Life Sciences, Virology Keywords: Hepatitis C virus; Genetic; Chronic Hepatitis C; Liver; Elastography

Online: 22 May 2023 (13:56:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0732.v1

Chronic Bacterial Airways disease: the Pernicious Global Health Challenge Hidden in Plain Sight

Mark L. Everard

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: chronic bacterial broncitis; airways disease; biofilms; microbiome; COPD; bronchiectasis

Online: 10 May 2023 (10:13:54 CEST)

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This manuscript is aimed at encouraging those interested in biofilms and their effects on microbial communities to view the study of chronic airways disease as one of the most challenging and potentially rewarding areas to focus on. To do this it is necessary to review how we have reached 2023 having made so little progress. It is more than two hundred years ago since the term bronchitis was proposed to describe diseases affecting the airways rather than the respiratory zone of the lungs. The main histological features were described in Laennec’s text of 1819. By the mid C20th it was recognised that the two great drivers of chronic respiratory symptoms were inhaled toxins and chronic bacterial infections. The widespread availability of antibiotics in subsequent years had a dramatic impact on mortality from pneumonia, greatly reduced the prevalence of chronic symptoms after acute lower respiratory tract infections, transformed the lives of many with bronchiectasis and appeared to play a major role in the dramatic fall in prevalence of bronchiectasis. Unfortunately, during the following 70 years the importance of dealing with a chronic bacterial bronchitis was largely forgotten. While two artificial diseases ‘COPD’ and ‘bronchiectasis’ have been the subject of numerous guidelines, chronic bacterial bronchitis has been out in the cold. Antibiotics have in theory been reserved for those with established damage in the form of bronchiolitis and impaired lung function as defined by an arbitrary FEV1/FVC ratio and even then there is a disconnect with a minimum of 2 weeks being prescribed for exacerbations of bronchiectasis and the use of long term inhaled and oral macrolides frequently being advocated while a 5 day course is reserved for an exacerbation in a patient with COPD. The loss of focus on the role of antibiotics has a number of causes – a desire to ration antibiotic as part of ‘antibiotic stewardship’, the potential cost of treatment, the failure to ‘cure’ patients with chronic bronchitis and the difficulty in dealing with a disease whose morbidity at any given time can range from a mild cough and production of phlegm in the morning with no obvious impact on daily function to troublesome cough, sputum production and significant ill health. This was compounded by the vagaries of culture based diagnosis and the observation that more than one potential pathogen was often present. As a result chronic bacterial bronchitis was relegated to the ‘too hard to deal with’ box and many of the lessons of the past were forgotten. Revisiting the field from the perspective of current understanding of bacterial behaviour in biofilms and how these alter the resident microbiota of the airways should ensure that a chronic bacterial bronchitis returns to centre stage in order to minimise respiratory morbidity and mortality. This review charts the history of our understanding and mis-understanding of the role of chronic bacterial bronchitis in airways disease and the pernicious effect of language in helping to ensure that this common and important condition became the elephant in the room. Focusing on the nature of chronic bacterial bronchitis is essential if we are to find ways of identifying it accurately and treat it effectively – new approaches will be extremely slow unless we recognise its importance and the challenges it poses.

Preprint ARTICLE | doi:10.20944/preprints202305.0580.v1

Prevalence of Clinical Signs and Symptoms of Temporomandibular Joint Disorders Registered in the EUROTMJ Database: A Prospective Study in a Portuguese Center

David Faustino Ângelo, Beatriz Mota, Ricardo São João, David Sanz, Henrique José Cardoso

Subject: Medicine And Pharmacology, Surgery Keywords: Temporomandibular joint disorders; parafunctional habits; risk factors; chronic diseases

Online: 9 May 2023 (07:10:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0211.v1

Klotho Regulated by Estrogen Plays a Key Role in Sex Differences in Stress Resilience

Zhinei Tan, Yongxia Li, Yinzheng Guan, Javed Iqbal, Chenyue Wang, Xinming Ma

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: klotho; estrogen; hippocampus; chronic stress; sex difference; stress resilience

Online: 13 December 2022 (01:09:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0152.v1

Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Massimo Sangiorgi, Mariangela Valentina Puci, Allegra Rosa Martelli, Teresa Messina, Paolo Frigatti, Maria Pia Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco Michelino Fiore, Armado Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, Diego Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Pietro Modugno, Maurizio Maiorano, Umberto Marcello Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, Giovanni Maria Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munaó, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio Stefano Tolva, Ilenia D'Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D'Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio Massimo Oddi, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: chronic limb-threatening ischemia; outcome; sex; age; limb salvage

Online: 8 December 2022 (09:39:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202206.0168.v1

The Impact of Spiritual-Based Care Interventions on the Quality of Life of Children with Chronic Diseases: a Philosophical Perspective

Idyatul Hasanah, Moses Glorino Rumambo Pandin, Tita Rohita

Subject: Public Health And Healthcare, Nursing Keywords: Nursing; Spiritual care; Quality of life; Chronic disease; Children

Online: 13 June 2022 (05:17:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0171.v1

The Antineoplastic Role of STAT5 Inhibition in BCRABL1-Positive Cells Exposed to Pimozide Alone and in Combination with Dasatinib and Ponatinib

Marco Santoro, Salvatrice Mancuso, Manlio Tolomeo, Rosaria Maria Pipitone, Stefania Grimaudo, Sergio Siragusa

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: chronic myeloid leukemia; dasatinib; ponatinib; pimozide; STAT inhibitors; K562

Online: 11 October 2021 (16:17:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0376.v1

Association of Migraine and Irritable Bowel Syndrome in Saudi Arabia: A Nationwide Survey.

Khalid A. Bin Abdulrahman, Nawaf S. Alenazi, Saad B. Albishri, Faisal F. Alshehri

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Migraine; Headache; Irritable Bowel Syndrome; Chronic Pain; Saudi Arabia

Online: 18 August 2021 (11:21:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0233.v1

Chronic Kidney Disease: Role of Diet for a Reduction in the Severity of the Disease

Tania Naber, Sharad Purohit

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Diabetes; Chronic Kidney Disease; Proteinuria; Dialysis; Inflammation; Diet; Nutrition

Online: 8 June 2021 (13:33:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0205.v1

Different Lower Extremity Arterial Calcification Patterns in Patients with Chronic Limb-Threatening Ischemia Compared with Asymptomatic Controls

Louise CD Konijn, Richard AP Takx, Willem PThM Mali, Hugo TC Veger, Hendrik van Overhagen

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: chronic limb-threatening ischemia; peripheral arterial disease; calcification pattern

Online: 7 April 2021 (14:45:17 CEST)

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Objectives The most severe type of peripheral arterial disease (PAD) is critical limb ischaemia (CLI). In CLI, calcification of the vessel wall plays an important role in symptoms, amputation rate and mortality. However, calcified arteries are also found in asymptomatic persons (non-PAD patients). We investigated whether the calcification pattern in CLI patients and non- PAD patients are different and could possibly explain the symptoms in CLI patients. Materials and Methods 130 CLI and 204 non-PAD patients underwent a CT of the lower extremities. This resulted in 118 CLI patients (mean age 72±12, 70.3% male) that were age-matched with 118 non-PAD patients (mean age 71±11, 51.7% male). The characteristics severity, annularity, thickness and continuity were assessed in the femoral and crural arteries and analysed by binary multiple logistic regression. Results Nearly all CLI patients have calcifications and these are equally frequent in the femoropopliteal (98.3%) and crural arteries (97.5%), while the non-PAD patients had in just 67% any calcifications with more calcifications in the femoropopliteal (70.3%) than in the crural arteries (55.9%, p<0.005). The crural arteries of the CLI patients had significantly more complete annular calcifications (OR 2.92, p=0.001.) while in the non-PAD patients dot-like calcifications dominated. In CLI patients, the femoropopliteal arteries had more severe, irregular / patchy and thick calcifications (OR 2.40, 3.27, 1.81, p≤0.05, respectively) while in non-PAD patients, thin continuous calcifications prevailed. Conclusions Compared with non-PAD patients CLI patients are more frequently and extensively calcified. Annular calcifications were found in the crural arteries of CLI patients while dot-like calcifications were mostly present in the non-PAD patients. These different patterns of calcifications in CLI point at different etiology and can have prognostic and eventually therapeutic consequences.

Working Paper REVIEW

CANOMAD : A Multi-Faceted Disease

Júlia Machado Rickli, Gabriela Pomaleski, Marcus Vinícius Magno Gonçalves

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: chronic-ataxic neuropathy; anti-disialosyl; IgM monoclonal gammopathy; CANOMAD

Online: 5 October 2020 (11:07:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0432.v1

Chronic Fatigue Syndrome and Fibromyalgia-Like Symptoms Are an Integral Component of the Phenome of Schizophrenia: Neuro-Immune and Opioid System Correlates

Rana Fadhil Mousa, Hussein Kadhem Al-Hakeim, Amir Alhaidari, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: chronic fatigue syndrome; myalgic encephalomyelitis; schizophrenia; neuroimmunomodulation; inflammation; biomarkers

Online: 29 March 2020 (10:52:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202001.0087.v1

DPP-4/GLP-1 Axis as a Potential Therapeutic Target in Chronic Stress-related Vascular Aging and Atherosclerosis

Ying Wan, Limei Piao, Yongshan Nan, Xian-Wu Cehng

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Chronic stress; Vascular senescence; inflamamtion; atherosclerosis; dipeptidyl peptidase-4

Online: 9 January 2020 (13:05:26 CET)

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Preprint REVIEW | doi:10.20944/preprints201906.0261.v1

Diagnostic Imaging in Pediatric Chronic Rhinosinusitis: A Guide for Clinicians

Giorgio Conte, Luca Caschera, Sandro Magnani, Claudia Cinnante, Fabio Maria Triulzi, Lorenzo Pignataro, Sara Torretta

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: rhinosinusitis; pediatric chronic rhinosinusitis; computed tomography; magnetic resonance imaging

Online: 26 June 2019 (07:21:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints201810.0033.v1

Viral Persistence and Chronicity in Hepatitis C Virus Infection: Role of T-Cell Apoptosis, Senescence and Exhaustion

Muttiah Barathan, Rosmawati Mohamed, Yean K. Yong, Meganathan Kannan, Jamuna Vadivelu, Alireza Saeidi, Marie Larsson, Esaki Muthu Shankar

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: apoptosis; viral persistence, hepatitis C virus; immunity; chronic infection

Online: 2 October 2018 (16:34:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0320.v1

Vitamin D Deficiency in Chronic Kidney Disease: Recent Evidence and Controversies

Pedro Henrique Franca Gois, Martin Wolley, Dwarakanathan Ranganathan, Antonio Carlos Seguro

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: vitamin D; vitamin D deficiency; chronic kidney disease; proteinuria

Online: 18 July 2018 (08:39:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0050.v1

The FDA and the State of Chronic Diseases: Cardiovascular, Endocrine, Pulmonary, and Renal Diseases

Mona Fiuzat, Michael P. Gray, Grace Anne Dorney Koppel, Aaron Kowalski, Prabir Roy-Chaudhury, Mary Norine Walsh, Daniel W. Jones, Enid Neptune, Robert Ratner, Melissa West, Brad A. Wong, Robert Califf

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: chronic diseases; cardiovascular; renal; endocrine; diabetes; therapeutic advances; tobacco

Online: 3 May 2018 (05:08:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints201802.0104.v1

Myeloperoxidase as an Active Disease Biomarker: Its Recent Biochemical and Pathological Perspectives

Amjad A. Khan, Mohammad A. Alsahli, Arshad H. Rahmani

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: myeloperoxidase, leukocytes, inflammation, oxidative stress, chronic diseases, disease biomarker

Online: 15 February 2018 (16:54:25 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202410.1956.v1

Complete Resolution of a Meningioma and Relief of Chronic Migraine Headaches after Endovascular Embolization Alone (Case Report)

Andrey Eugenievich Petrov, Arkady Aleksandrovich Ivanov, Ekaterina Samorukova, Julia Suvorova, Anna Petrova, Konstantin Samochernykh, Larisa Rozhchenko

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: endovascular embolization; meningioma; Squid; middle meningeal artery; chronic migraine; headache

Online: 25 October 2024 (10:00:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.0824.v1

Bioactivity, Efficacy, and Safety of a Wound Healing Ointment with Medicinal Plant Bioactives: In Vitro and In Vivo Preclinical Evaluations

Juliana Floriano, Daniel Rodrigues, Rie Ohara, Nara Almeida, Vanessa Soares, Patricia Sartorelli, Carlos Graeff, Simone Grecco, Alejandra González, Paulo D'Alpino

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: chronic wounds; wound care; natural compounds; biocompatibility; pre-clinical tests

Online: 10 October 2024 (12:59:40 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202409.1467.v1

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (Me/Cfs) Hypothesis: Three Subtypes of Noradrenergic Neuron Dysfunction

Tamara Carnac

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Myalgic Encephalomyelitis; Chronic Fatigue Syndrome; ME/CFS; Norepinephrine; Insulin; Neuron

Online: 19 September 2024 (04:31:27 CEST)

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Myalgic Encephalomyelitis (ME), sometimes called Chronic Fatigue Syndrome (CFS), is a complex, debilitating condition characterised by symptoms such as profound fatigue, autonomic dysfunction, gastrointestinal problems, unrefreshing sleep, cognitive problems, exercise intolerance and post-exertional malaise (PEM) (a worsening of symptoms after mild physical or mental effort). The pathophysiology of ME remains poorly understood. This paper proposes a novel hypothesis centred on norepinephrine dysregulation and insulin signaling as the underlying mechanisms contributing to distinct subtypes of ME. I hypothesise that ME can be categorised into three subtypes based on variations in norepinephrine transport and insulin signaling: ME1, ME2, and ME3. In ME1, a higher than normal rate of insulin secretion during the first phase insulin response and/or hypersensitive insulin receptors leads to reduced neuronal norepinephrine reuptake, resulting in elevated extracellular norepinephrine and subsequent down-regulation of beta-2 adrenergic receptors. ME2 is characterised by prolonged insulin release and insulin resistance, which may contribute to the development of postural orthostatic tachycardia syndrome (POTS) and microclot formation. ME3 is marked by reduced norepinephrine synthesis and a resultant deficiency of norepinephrine within neurons. All three subtypes involve a deficiency of norepinephrine inside the noradrenergic neuron which is worsened by physical and mental exertion. There are many similarities between ME and Long COVID. Both have their onset after a virus and have a similar symptom profile, as well as having the same co-occurring conditions such as mast cell activation and POTS. It is quite possible that a subset of Long COVID patients have ME, and so I will be referring to both ME and Long COVID research papers throughout this hypothesis paper. This hypothesis integrates genetic, metabolic, and neuroendocrine data to delineate these subtypes and suggests tailored diagnostic and therapeutic approaches for each. This hypothesis aims to guide future research into the distinct pathophysiological mechanisms of ME and enhance understanding and management of this debilitating condition.

Preprint REVIEW | doi:10.20944/preprints202408.1754.v1

Mechanistic Insights on Microbiota-Mediated Development and Progression of Esophageal Cancer

Kyaw Thu Moe, Kevin Shyong Wei Tan

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Esophageal cancer; oral microbiota; microbial dysbiosis; carcinogenic metabolites; chronic inflammation

Online: 23 August 2024 (15:03:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0681.v1

Using HL7-FHIR as an Integration Platform for Chronic Disease Services Management and Planning in the Irish Healthcare Sector

Vuong M. Ngo, Geetika Sood, Fionnuala Donohue, Patricia Kearney, Claire Buckley, Mark Roantree

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Chronic diseases; Record linkage; Fast healthcare interoperability resources; Federated database

Online: 9 August 2024 (09:38:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0594.v1

Senescence Biomarkers CKAP4 and PTX3 Stratify Severe Kidney Disease Patients

Sean McCallion, Thomas McLarnon, Eamonn Cooper, Andrew English, Steven Watterson, Melody Chemaly, Cathy M. McGeough, Amanda Eakin, Tan Ahmed, Philip Gardiner, Adrian Pendleton, Gary Wright, Declan McGuigan, Maurice O'Kane, Aaron Peace, Ying Kuan, David S. Gibson, Paula L. McClean, Catriona Kelly, Victoria E. McGilligan, Elaine K. Murray, Frank McCarroll, Anthony J. Bjourson, Taranjit Singh Rai

Subject: Biology And Life Sciences, Aging Keywords: Senescence; chronic kidney disease; acute kidney injury; biomarker; machine learning

Online: 8 August 2024 (08:48:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0167.v1

Elucidating the Causal Link Between Hearing and Chronic Kidney Disease Through Mendelian Randomization and Development of Predictive Machine Learning Models Based on NHANES Data

Yanting Yang, Yuqing Li, Zhongquan Huang, Rongrong Lin, Zhuoni Chen, Ning Zhang, Nan Zheng, Jiean Xu, Yaqi Zhou

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Chronic kidney disease; Hearing; Mendelian randomization; Machine learning models; Predictions

Online: 2 August 2024 (10:56:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0048.v1

A Focus on the Metabolic Dysfunction of Proximal Tubule Cells in Dent Disease Type 1

Elise de Combiens, Imene Bouchra Sakhi, Stéphane Lourdel

Subject: Medicine And Pharmacology, Anatomy And Physiology Keywords: Dent disease type 1; proximal tubule; metabolism; chronic kidney disease

Online: 1 August 2024 (12:02:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.1346.v1

Perioperative Buprenorphine Management and Post-Operative Pain Outcomes: A Retrospective Study with Literature Review and Recommendations

Amruta Desai, Shruti Parikh, Sergio Bergese

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: ; buprenorphine; perioperative medicine; chronic pain; opioid use disorder ;

Online: 21 May 2024 (05:33:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1837.v1

Disturbances in the Skin Homeostasis: The Wound Healing, a Process Yet to Be Defined

Montserrat Fernández-Guarino, Jorge Naharro-Rodriguez, Stefano Bacci

Subject: Biology And Life Sciences, Life Sciences Keywords: acute wounds; chronic wounds; hypertrophic scars; keloids; skin; wound healing

Online: 28 April 2024 (08:29:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1646.v1

Predicting Cognitive Impairment in Patients with Chronic Traumatic Encephalopathy: A Single-Center Prospective Cohort Study

Khrystyna Duve, Pavlo Petakh, Valentyn Oksenych, Oleksandr Kamyshnyi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: chronic traumatic encephalopathy; traumatic brain injury; cognitive impairment; logistic regression

Online: 25 April 2024 (08:45:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0645.v1

Best Administration Schedule for Optimal Efficacy and Safety of Arsenic Trioxide Treatment in Chronic Graft versus Host Disease

Dominique Rongvaux-Gaïda, Lieven Huysse, François Rieger, Carole Nicco

Subject: Medicine And Pharmacology, Hematology Keywords: Arsenic trioxide; Chronic Graft-versus-Host Disease; cGvHD; Corticosteroid; autoimmunity

Online: 11 March 2024 (15:18:01 CET)

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Chronic graft-versus-host disease (cGvHD) occurs in 20-50% of recipients following allogeneic haematopoietic stem cell transplantation (allo-HSCT). Corticosteroids (CS) remain the first line treatment but have suboptimal efficacy and carry the risk of long-term side effects. New agents with a better safety profile and higher efficacy, ideally combining immunomodulatory and antifibrotic properties, are urgently needed. From 2016 to 2020, we conducted a phase 2 clinical trial with ATO in chronic GvHD (ClinicalTrials.gov ID NCT02966301 - GMED16-001). This study aimed to evaluate the efficacy and safety of a first-line combination of arsenic trioxide (ATO) and CS in adult patients with cGvHD who require systemic therapy after a first allo-HSCT for a haematological disease. In this prospective, national, multicenter, single-arm, open-label phase II study, conducted in 5 university hospital centers in France, ATO was initiated within 10 days of starting CS at 1 mg/kg/day. Patients received 11 infusions of ATO per 4-week cycle, at a dose of 0.15 mg/kg per infusion. Patients received 1 or 2 cycles of treatment depending on the clinical response and the assessment of the treating physician. The results were published in July 2022 in a paper entitled "High Response Rate and Corticosteroid Sparing with ATO-Based First-Line Therapy in Chronic Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation". The GMED16-001 study demonstrated convincing efficacy and safety characteristics of the intravenous drug (Trisenox^®/Arscimed^®): the first-line use of ATO in addition to corticosteroids was associated with a high clinical response rate and correlated with rapid corticosteroid (CS) sparing in moderate to severe cGvHD after allo-HSCT. We performed a post-hoc analysis of the data to determine the best schedule for treating cGvHD patients with ATO. Our post-hoc analysis leads us to the conclusion that two cycles of ATO, at 0.15 mg/kg/day, 5 days per week for 4 weeks each, separated by a 4-week therapy-free interval, appears to be the most promising treatment schedule.

Preprint ARTICLE | doi:10.20944/preprints202402.1507.v1

Optimizing Flexible Microelectrode Designs for Enhanced Efficacy in Electrical Stimulation Therapy

Lihong Qi, Ying Yu, Zeru Tao, Mujie Liu, Yongwei Jiang, Kai Yao, Yuheng Wang

Subject: Engineering, Electrical And Electronic Engineering Keywords: Flexible; Serpentine Structure; MEMS; Electrical Stimulation Therapy; Chronic Wound Healing

Online: 27 February 2024 (10:23:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1486.v1

Herpesvirus Infection as a Systemic Pathological Axis in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Jean M Nunes, Douglas B Kell, Etheresia Pretorius

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS); Endothelial cells; Herpesvirus

Online: 19 January 2024 (13:13:19 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0620.v1

From Acute to Chronic: Unraveling the Pathophysiological Mechanisms of Acute Kidney Injury, Acute Kidney Disease to Chronic Kidney Disease Progression

Tzu-Hsuan Yeh, Kuan-Chieh Tu, Hsien-Yi Wang, Jui-Yi Chen

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Acute kidney injury; Acute kidney disease; biomarker; chronic kidney disease

Online: 8 January 2024 (11:28:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0675.v1

Prevalence of Fetal Inflammatory Response Syndrome and Villitis of Unknown Etiology in the Placenta of Saudi Women and Their Association with Baby Gender

Waleed Mohammed Aldahmash, Khaldoon Aljerian, Saleh Hamed Alwasel

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Inflammatory Response Syndrome; VUE; chronic deciduitis; CD8; CD68; Placenta; gender

Online: 10 November 2023 (07:29:45 CET)

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Long-term health consequences are influenced by circumstances that occur during pregnancy. The confluence of the maternal and fetal circulations occurs at the placenta, which is the first or-gan to develop. Placental pathology can provide an accurate diagnosis of inflammation inside the amniotic sac. The pathological alterations of preterm placentas provide evidence for the causes of numerous perinatal pathologies, including spontaneous preterm births. This retrospec-tive study aimed to re-examine placentas regarded as normal by the Obstetrics and Gynecology Department in our institution so that grading and staging of any evident inflammatory response could be evaluated and associated with baby gender. Eighty-four full-term placentas were col-lected after delivery. Placentas that were considered normal and were not sent to the histo-pathology department were taken. Morphological examination of fresh placenta was conducted. Full thicknesses of placenta samples were taken from central and marginal regions of placental disc. Fetal and maternal inflammatory responses syndrome were assessed. Villitis of unknown etiology (VUE) and chronic deciduitis also were evaluated in the placenta. Immunohistochemis-try (IHC) was also performed to evaluate patterns of inflammation in the placenta using an-ti-CD8 and anti-CD68 antibodies. The correlation between the silent pathologies and clinical complications or involvement of developing fetal inflammatory response syndrome was meas-ured. In this study, seventeen (20%) maternal inflammatory samples and ten (12%) fetal inflam-matory samples showed inflammatory responses. The frequency of chronic deciduitis and villi-tis of unknown etiology was more remarkable among Saudi pregnant women than the previ-ously reported findings in the literature of placental pathology. The prevalence of fetal and ma-ternal inflammatory response was greater in the placentas of mothers of males than in placentas of female mothers. Grading placental inflammation usually predict the degree of maternal an-ti-fetal cellular rejection. Fetal inflammatory response syndrome usually goes unnoticed in Sau-di Arabia. There are differences in the inflammatory response in the placenta based on the sex of the newborn. Increasing the number of placental samples that must be sent for microscopic in-spection may be preferable due to their significance in identifying the causes of chronic disor-ders.

Preprint ARTICLE | doi:10.20944/preprints202310.1870.v1

Study on Mechanism of Lactobacillus rhamnosus Mitigating PFOA/PFOS Toxicity in Adult Zebrafish (Danio rerio)

Guanyi Li, Sibao Chen, Ruixuan Li, Mengyan Wang, Jinjin Li, Mengmeng Yi, Yingxue Sun, Chun Wang

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: PFOA; PFOS; Lactobacillus rhamnosus; Chronic toxicity; Oxidative stress; Gut microbiota

Online: 30 October 2023 (08:41:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0971.v1

Cardiac Abnormalities in a Predictive Mouse Model of Chagas Disease

Amanda Fortes Francisco, Giovane R. Sousa, Mhairi Vaughan, Harry Langston, Archie Khan, Shiromani Jayawardhana, Martin C. Taylor, Michael D. Lewis, John M. Kelly

Subject: Biology And Life Sciences, Parasitology Keywords: Trypanosoma cruzi; electrocardiography (ECG); Chronic Chagas Cardiomyopathy; Chagas heart disease

Online: 16 October 2023 (12:36:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0538.v1

Prognostic Significance of Amino Acid and Biogenic Amines Profiling in Chronic Kidney Disease

Guillermo Gervasini, Zoraida Verde, Luz María González, Celia Chicharro, Laura González-Rodríguez, Ana Fernández-Araque, Sonia Mota-Zamorano, Alberto Pérez-Hernández, Virginio García-López, Fernando Bandrés, Nicolás Roberto Robles

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Chronic kidney disease; End-stage kidney disease; amino acids; metabolites

Online: 7 September 2023 (11:24:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1808.v1

Oroxylum indicum Seed Extract as a Potential Antidepressant in Chronic Stress Mouse Model of Depression

Chorpeth Chalermwongkul, Charinya Khamphukdee, Supawadee Daodee, Orawan Monthakantirat, Chantana Boonyarat, Yutthana Chotritthirong, Juthamart Maneenet, Suresh Awale, Anake Kijjoa, Yaowared Chulikhit

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: Oroxylum indicum, baicalein, unpredictable chronic mild stress, HPA-axis, depression

Online: 28 August 2023 (03:35:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1294.v1

The Mediating Effects of Social Networks and Wisdom on the Relationship between Lifestyle Habits and Healthy Aging in Older Adults with Chronic Diseases

Hee-Kyung Kim, Hye-Suk Oh, Cheol-Hee Park

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: elderly; healthy aging; lifestyle habits; social networks; wisdom; chronic disease

Online: 19 July 2023 (09:53:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1898.v1

First-line Treatment of the Older Patients with CLL: A New Approach in the Chemo-free Era

Antonio Urso, Francesco Cavazzini, Maria Pia Ballardini, Silvia Gambara, Sara Consolo, Gian Matteo Rigolin, Antonio Cuneo

Subject: Medicine And Pharmacology, Hematology Keywords: chronic lymphocytic leukemia; older patient; ibrutinib; acalabrutinib; zanubrutinib; venetoclax; sustainabiity

Online: 27 June 2023 (12:04:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1749.v1

A Glow Before Darkness: Toxicity of Glitter Particles to Marine Invertebrates

Denis Moledo de Souza Abessa, Letícia França Albanit, Pedro Henrique Paixão de Moura, Vitória Soares Nogueira, Felipe Teixeira Santana, Kainã Fagundes, Maysa Ueda, Otto Patrão de Oliveira Muller, Caio Cesar-Ribeiro

Subject: Environmental And Earth Sciences, Pollution Keywords: Microplastics; ecotoxicology; marine pollution; contaminants of emerging concern, chronic toxicity.

Online: 26 June 2023 (05:33:01 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202305.0560.v1

Effects of Whole-Body Cryostimulation on pain management and disease activity in active Rheumatic Polymyalgia: a Case-Report

Federica Verme, Alessandra Scarpa, Giorgia Varallo, Paolo Piterà, Paolo Capodaglio, Jacopo Maria Fontana

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Polymyalgia Rheumatica; Whole-Body Cryostimulation; Chronic Pain; Disease Activity; Rehabilitation

Online: 9 May 2023 (04:17:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0483.v1

Causal Variables in the Association between Physical Well-Being and Chronic Pain: Results from a Cohort Study in Galicia (Northwest Spain)

Roya Karimi, Jesús Prego-Domínguez, Bahi Takkouche

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Chronic pain; confounding; interaction analysis; mediation analysis; physical well-being

Online: 8 May 2023 (08:50:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0549.v1

Beraprost and Overall Survival in Cats With Chronic Kidney Disease

Hiroyuki Ito, Takumi Matsuura, Tadashi Sano

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: beraprost; feline; chronic kidney disease; progression-free survival; overall survival

Online: 31 March 2023 (11:17:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202301.0447.v1

Still Finding Ways to Augment the Existing Management of Acute and Chronic Kidney Diseases with Targeted Gene and Cell Therapies: Opportunities and Hurdles

Peter Corridon

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: acute kidney disease; chronic kidney disease; gene therapy; cell therapy

Online: 25 January 2023 (04:29:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0039.v1

Genomic Analysis of Adaptation of the MRSA ST239 Strains to the Development of Various Types of the Infectious Process

Olga Alexandrovna Dmitrenko, Andrey Viktorovich Chaplin, Anna Alexandrovna Balbutskaya, Tamara Yakovlevna Pkhakadze, Sergey Vladimirovich Alkhovsky

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Staphylococcus aureus, MRSA ST239, osteomyelitis, genome features, adaptation; chronic infection

Online: 2 November 2022 (03:34:29 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202209.0035.v2

Application of Amniotic Membrane Allografts in Advanced Venous Leg Ulcer: A Case Study and Literature Review

Naomi Lambert, Eric Vinke, Tyler Barrett, Matthew Regulski

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Chronic Venous Insufficiency; Venous Leg Ulcer; Dehydrated Amniotic Membrane Allograft

Online: 5 September 2022 (10:57:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0008.v1

CRISPR/Cas9-directed Gene Trap Constitutes a Selection System for Corrected BCR/ABL Leukemic Cells in CML

Elena Vuelta, José Luis Ordoñez, David José Sanz, Sandra Ballesteros, Jesús María Hernández-Rivas, Lucía Méndez-Sánchez, Manuel Sánchez-Martín, Ignacio García-Tuñón

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Chronic Myeloid Leukaemia; BCR/ABL; CRISPR; Gene therapy; CRISPR-Trap.

Online: 4 May 2022 (12:30:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0217.v1

Factors Associated with the Prevalence of Malnutrition among Adult Haemodialytic Patients: A Two-Centre Study in Jeddah Region, Saudi Arabia

Firas S. Azzeh, Waad M. Turkistani, Mazen M. Ghaith, Lujain A. Bahubaish, Osama A. Kensara, Hussain A. Almasmoum, Abdullah F. Aldairi, Anmar A. Khan, Ahmad A. Alghamdi, Ghalia Shamlan, Maha H. Alhussain, Reham M. Algheshairy, Abdullah M. AlShahrani, Maysoun S. Qutob, Awfa Y. Alazzeh, Haitham M. Qutob

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Chronic Kidney Disease; Protein-Energy Wasting; Modified-Subjective Global Assessment

Online: 25 April 2022 (04:53:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0290.v3

Epigenetic Modulation of Gremlin-1/NOTCH Pathway in Experimental Crescentic Immune-Mediated Glomerulonephritis

Lucia Tejedor-Santamaria, Jose Luis Morgado-Pascual, Laura Marquez-Exposito, Beatriz Suarez-Alvarez, Raul R. Rodrigues-Diez, Antonio Tejera-Muñoz, Vanessa Marchant, Sergio Mezzano, Carlos López-Larrea, Anna Sola, Gema Maria Fernandez-Juarez, Alberto Ortiz, Sandra Rayego-Mateos, Marta Ruiz-Ortega

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: crescentic glomerulonephritis; BET proteins; NOTCH; GREMLIN; Chronic kidney disease; Bromodomain

Online: 23 December 2021 (14:40:45 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202108.0267.v1

From Oncological Paradigms to Non-Communicable Disease Pandemic. The Need of Recovery Human Biology Evolution

Elia Biganzoli, Romano Demicheli

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Cancer dormancy; Low-grade chronic inflammation; Healthy aging; Physical exercise

Online: 11 August 2021 (17:57:09 CEST)

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