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Preprint ARTICLE | doi:10.20944/preprints202311.0685.v1

Chemical Composition and Genome Pattern as a Means of Identifying the Origin of Preserved Wild Garlic (Allium ursinum L.) in Poland

Emilia Bernaś, Jacek Słupski, Piotr Gębczyński, Katarína Ražná, Jana Žiarovská

Subject: Biology And Life Sciences, Food Science And Technology Keywords: wild garlic; freezing; air-drying; freeze-drying; genome pattern; polyphenol; antioxidant activity

Online: 10 November 2023 (07:15:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0677.v1

Application of Various Genomic Selection Models in Cotton Fiber Quality

Dongdong Zhai

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Genomic selection; Cotton; Fiber quality

Online: 10 November 2023 (06:52:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0669.v1

On Some Properties of a Complete Quadrangle

Vladimir Volenec, Marija Šimić Horvath, Ema Jurkin

Subject: Computer Science And Mathematics, Hardware And Architecture Keywords: complete quadrangle; diagonal triangle; anticenter

Online: 10 November 2023 (01:54:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0643.v1

Does Impaired Plantar Cutaneous Vibration Perception Contribute to Axial Motor Symptoms in Parkinson’s Disease? Effects of Medication and Subthalamic Nucleus Deep Brain Stimulation

Tobias Heß, Peter Themann, Christian Oehlwein, Thomas L. Milani

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Parkinson’s disease; axial motor symptoms; postural instability & gait difficulties; functional limits of stability; non-motor sensory symptoms; sensorimotor integration; somatosensory system; plantar cutaneous vibration perception thresholds; deep brain stimulation; subthalamic nucleus

Online: 10 November 2023 (01:49:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0658.v1

Scientometric Analysis of Scientific Production on Digital Transformation Banking

Álvaro Cepeda-Ortiz, Miguel Angel González

Subject: Business, Economics And Management, Business And Management Keywords: Digital Transformation; Banking; financial services; scientometrics; web of science; vosviewer

Online: 10 November 2023 (01:48:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0666.v1

Synergistic Flame-Retardant Effect of DOPO-Based Derivative and Modified Sepiolite on Flame Retardancy, Thermal Decomposition and Mechanical Properties of PEO/PBAT Blends

Weijiang Huang, Chunyun Tu, Qin Tian, Kui Wang, Chunlin Yang, Chao Ma, Xiaolu Xu, Wei Yan

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: poly (ethylene oxide); poly (butylene adipate-co-terephthalate); DOPO-based flame retardant; sepiolite; synergistic effect

Online: 9 November 2023 (17:09:12 CET)

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A bridged 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) derivative (PN-DOPO) in combination with aluminum phosphates coated sepiolite (Sep@AlPO4) was used to improve the flame retardancy, thermal stability and mechanical properties of poly (ethylene oxide) (PEO)/poly (butylene adipate-co-terephthalate) (PBAT) blends. The synergistic effects of PN-DOPO and Sep@AlPO4 on the fire resistance, thermal decomposition behavior and mechanical properties of PEO/PBAT composites were investigated systematically. The results indicated that 5 wt % Sep@AlPO4 combined with 10 wt% PN-DOPO into PEO/PBAT achieved a V-1 rating in UL-94 test and the LOI value increased to 23.7%, meanwhile, the peak-heat release rate (p-HRR), av-HRR and total heat release (THR) values of PEO/PBAT/PN10%/Sep5% composites decreased by 35.6%, 11.0% and 23.0% compared with those of PEO/PBAT, respectively. The thermogravimetric analysis (TGA) results confirmed that PN-DOPO/Sep@AlPO4 could enhance the initial thermal stability and char yield of PEO/PBAT matrix, and TGA/Fourier transform infrared spectrometry (TGA-FTIR) results revealed that the composites exhibited the absorption peaks of phosphorous-containing groups and an increase in gas-phase volatiles during the thermal decomposition process. The digital photographs and morphological structures of char residues demonstrated that PN-DOPO and Sep@AlPO4 mixtures benefited to the formation of a more continuous and dense carbon layer on the composites surface during combustion. Rheological behavior revealed that a higher storage modulus, loss modulus and complex viscosity of PEO/PBAT/PN-DOPO/Sep@AlPO4 composites could also promote the cross-linking structure during burning. Furthermore, the PEO/PBAT/PN-DOPO/Sep@AlPO4 composites exhibited excellent mechanical properties in terms of elongation at break and flexural performance than the PEO/PBAT system. All the results demonstrated that PEO/PBAT system modified by the combination of PN-DOPO and Sep@AlPO4 not only exhibited excellent synergistic effect on the flame retardance, but also had good improvement on thermal stability and mechanical properties, indicating the potential application in areas requiring fire safety.

Preprint REVIEW | doi:10.20944/preprints202311.0665.v1

Vehicle Relocation in One-Way Carsharing: A Review

Afnan Fayez Eliyan, Laoucine Kerbache

Subject: Engineering, Transportation Science And Technology Keywords: Carsharing; Vehicle balancing; Resource dimensioning; Fleet management; Trip pricing

Online: 9 November 2023 (16:44:20 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.0664.v1

Wireless Technology Security and Privacy: A Comprehensive Study

Hamza Azam, Micheal Tan, Lim Tik Pin, Muhammad Afiq Syahmi, Antony Liew Wen Qian, Huang Jingyan, Muhammad Fuhad Uddin, Siva Raja Sindiramutty

Subject: Computer Science And Mathematics, Computer Science Keywords: Intrusion Prevention System (IPS); Intrusion Detection System (IDS); Intrusion Detection and Presentation System (IDPS); Deep Packet Inspection (DPI); Network-Based Prevention System (NIPS)

Online: 9 November 2023 (16:13:31 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202311.0655.v1

High Repetition Frequency Solid-State Green Laser with Large Stable Area for Water Jet Guided

Ji Wang, Wenwu Zhang

Subject: Engineering, Mechanical Engineering Keywords: high stable; stable zone; water jet guided laser; green laser; high repetition frequency

Online: 9 November 2023 (15:11:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0653.v1

Exploring Novel Variants of Cytochrome P450 Reductase Gene (POR) from the Genome Aggregation Database by Integrating Bioinformatic Tools and Functional Assays

Maria Natalia Rojas Velazquez, Søren Therkelsen, Amit V. Pandey

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Cytochrome P450 oxidoreductase; POR; gnomAD, CAH; drug metabolism, steroid hormones; SNV; bioinformatics

Online: 9 November 2023 (15:09:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0654.v1

The Antiviral Potential of AdipoRon, an Adiponectin Receptor Agonist, Reveals the Ability of Zika Virus to Deregulate Adiponectin Receptor Expression

Daed El Safadi, Grégorie Lebeau, Jonathan Turpin, Christian Lefebvre d’Hellencourt, Nicolas Diotel, Wildriss Viranaicken, Pascale Krejbich-Trotot

Subject: Biology And Life Sciences, Virology Keywords: Zika virus; antiviral; AdipoRon; adiponectin agonist; drug repositioning; metabolism

Online: 9 November 2023 (15:07:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0661.v1

Survival and Recurrence of Endocarditis Following Mechanical vs. Biological Aortic Valve Replacement in Patients Aged 40 to 65 Years: Data from the INFECT-REGISTRY

Antonio Salsano, Michele Di Mauro, Laura Labate, Alessandro Della Corte, Federica Lo Presti, Michele De Bonis, Cinzia Trumello, Mauro Rinaldi, Erik Cura Stura, Guglielmo Actis Dato, Giuseppe Punta, Francesco Nicolini, Davide Carino, Carlo De Vincentiis, Andrea Garatti, Giangiuseppe Cappabianca, Andrea M Musazzi, Diego Cugola, Maurizio Merlo, Davide Pacini, Gianluca Folesani, Sandro Sponga, Igor Vendramin, Alberto Pilozzi Casado, Francesco Rosato, Elisa Mikus, Carlo Savini, Francesco Onorati, Giovanni Battista Luciani, Roberto Scrofani, Francesco Epifani, Francesco Musumeci, Antonio Lio, Andrea Colli, Giosuè Falcetta, Salvatore Nicolardi, Salvatore Zaccaria, Enrico Vizzardi, Antonio Pantaleo, Giuseppe Minniti, Emmanuel Villa, Margherita Dalla Tomba, Francesco Pollari, Fabio Barili, Alessandro Parolari, Roberto Lorusso, Francesco Santini

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: endocarditis; aortic valve replacement; prosthetic heart valve.

Online: 9 November 2023 (15:01:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0662.v1

Estimating of Carbon and Nitrogen Content in Forest Ecosystems in the Background Areas of the Russian Arctic (Murmansk Region)

Vyacheslav Ershov, Tatyana Sukhareva, Nikolay Ryabov, Ekaterina Ivanova, Irina Shtabrovskaya

Subject: Environmental And Earth Sciences, Environmental Science Keywords: northen taiga forests; atmospheric fallout; soils; Picea obovata; Pinus sylvestris; carbon; nitrogen; Arctic

Online: 9 November 2023 (14:54:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0657.v1

The Effect of the Stringent Response and Oxidative Stress Response on Fitness Costs of De Novo Acquisition of Antibiotic Resistance

Wenxi Qi, Drosos Katsavelis, Wim De Leeuw, Meike T. Wortel, Martijs J. Jonker, Benno H. Ter Kuile

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: de novo antibiotic resistance; fitness cost; (p)ppGpp; reactive oxygen species; compensatory evolution

Online: 9 November 2023 (14:53:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0659.v1

Lumbar Pain in Patients with Multiple Sclerosis and Knowledge about Physiotherapeutic Methods of Combating

Martyna Odzimek, Waldemar Brola, Józef Opara

Subject: Public Health And Healthcare, Other Keywords: Low back pain (LBP); multiple sclerosis (MS); physiotherapy

Online: 9 November 2023 (14:51:37 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.0656.v1

Revolutionizing Vaccine Development for COVID-19: A Review of AI-Based Approaches

Aritra Ghosh, Maria M. Petrie, Mirjana Pavlović

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: COVID-19; AI-based approach; vaccine development

Online: 9 November 2023 (14:51:09 CET)

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AI-based approaches are increasingly being used to revolutionize vaccine development for COVID-19. Small molecules, peptides, and epitopes are being collected for therapy discovery, which could also direct AI-based models, screening, or generation [1]. AI-based models are being used for drug discovery and vaccine development, and pre-existing data is being leveraged through machine learning approaches for COVID-19 drug discovery and vaccine development [1]. The best candidate targets for future treatment development are being identified and evaluated using AI-based models [1]. AI-based approaches can be used to overcome challenges in manufacturing, storage, logistics, and safety and efficacy issues related to different vaccine candidates for COVID-19 [2]. AI algorithms can help identify the best vaccine candidates for COVID-19 while considering the efficiency of antigenic peptides for immune response generation [2]. The presentation of antigenic peptides by major histocompatibility complex (MHC) class II molecules is the first step after COVID-19 vaccine administration for any vaccine-induced immune response [2]. Thus, AI-based models are being used to identify the best vaccine candidates for COVID-19 and to ensure that the vaccine-induced immune response is efficient and safe. The utilization of AI-based methods to address logistical, manufacturing, storage, safety, and efficacy issues regarding several COVID-19 vaccine candidates will be examined in this study. Additionally, while considering the effectiveness of antigenic peptides for the induction of an immune response, we will determine the best potential targets for the next treatment development and assess how AI-based models can help discover the best vaccine candidates for COVID-19. This research ultimately intends to offer insights into how AI-based techniques can transform COVID-19 vaccine development and how they can be applied to address vaccine development issues. In this paper, we focus on recent advances in using artificial intelligence to develop COVID-19 drugs and vaccines, as well as the potential of intelligent training in discovering COVID-19 therapeutics, highlighting potential challenges and solutions.

Preprint ARTICLE | doi:10.20944/preprints202311.0660.v1

Effect of Solar Pre-drying and Yeast Starter Inoculation Treatments on the Chemical Composition of Cocoa (Theobroma cacao L.) Beans from Southwestern Colombia

Juan Florencio Tejeda, Jéssica Arango-Angarita, Jairo Leonardo Cuervo

Subject: Biology And Life Sciences, Food Science And Technology Keywords: cocoa beans; pre-drying; yeasts; chemical composition

Online: 9 November 2023 (14:50:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0650.v1

Thermal Characteristics of Dry Gas Seal in Startup Process Considering Microscale Effects

Qiangguo Deng, Xuejian Sun, Hengjie Xu, Wenyuan Mao

Subject: Engineering, Mechanical Engineering Keywords: dry gas seal; thermal characteristics; slip flow; acceleration mode

Online: 9 November 2023 (14:47:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0647.v1

Typical Village and Town Houses in the Cold Region of Northeast China Simulation Analysis of Courtyard Layout and Winter Wind Environment Habitability

Ruiheng Sun, Junyan Dong, Hui Zhao, Liying Wang, Di Qin

Subject: Engineering, Architecture, Building And Construction Keywords: severe cold region; village houses; courtyard layout; wind environment; numerical simulation

Online: 9 November 2023 (14:41:21 CET)

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Preprint SHORT NOTE | doi:10.20944/preprints202311.0649.v1

Insights on Ferritin as a Screening and a Diagnostic Marker for Still’s Disease: A Narrative review

Zeal Soni, Samkit Vora, Dev Desai

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Still’s Disease; Ferritin; Arthritis

Online: 9 November 2023 (14:39:52 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.0651.v1

Interpreting Rectal MRI Post-Neoadjuvant Therapy

Joao Miranda, Pamela Causa Andrieu, Josip Nincevic, Lucas de Padua Gomes de farias, Hala Khasawneh, Yuki Arita, Nir Stanietzky, Maria Clara Fernandes, Tiago Biachi De Castria, Natally Horvat

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: rectal cancer; neoadjuvant therapy; magnetic resonance imaging; treatment response

Online: 9 November 2023 (14:38:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0648.v1

Electroencephalogram-Based Human Performance Analysis for Improved Small Modular Reactor Operation

John Gaber, Jing Ren, Hossam A.Gabbar

Subject: Engineering, Safety, Risk, Reliability And Quality Keywords: Human Performance; Mental Model; EEG; SMR; Plant Operation; Human Factors

Online: 9 November 2023 (14:28:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0640.v1

Opto-Magnetic Imaging Spectroscopy Based on Hyper Convolution Spectra and Its Applications

Lidija Matija, Branislava Jeftic, Aleksandra Dragicevic, Ivana Stanković, Vlado Antonic, Djuro Koruga

Subject: Biology And Life Sciences, Biophysics Keywords: hyper convolution spectra; epithelial tissues; paramagnetism; diamagnetism; opto-magnetic images; cancer detection; accuracy

Online: 9 November 2023 (14:24:05 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.0644.v1

Mathematical and Statistical Review of NMR Frequency Domain Data Pre-processing

Aixiang Jiang

Subject: Computer Science And Mathematics, Signal Processing Keywords: NMR pre-processing; phase error correction; baseline correction; reference deconvolution; integration and quantification; normalization and transformation

Online: 9 November 2023 (14:22:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints201907.0326.v2

Demonstration to Unify 4 Interactions in Particle Physics with the Zero‐Point Energy and Quantized Spacetime

Shinichi Ishiguri

Subject: Physical Sciences, Particle And Field Physics Keywords: zero‐point energy; quantized spacetime; static electromagnetic field; gravity field; weak interaction; strong interaction; masses of W and Z; β collapse; quantized Einstein gravity equation

Online: 9 November 2023 (13:40:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0652.v1

Wind Effects on Re-entrant Wing Faces of Plus Plan Shape Building

Arun Kumar, Rahul Kumar Meena, Ritu Raj, Mohammad Iqbal Khan, Jamal M. Khatib

Subject: Engineering, Civil Engineering Keywords: “ +” shape model; re-entrant corners; pressure coefficient; k-e model; tall building

Online: 9 November 2023 (13:39:38 CET)

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Preprint REVIEW | doi:10.20944/preprints202309.1149.v2

Critical Review of Neural Network Generations and Models Design

Jabar H. Yousif, Mohammed J. Yousif

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: neural networks; machine learning; convolutional neural networks; computational complexity; ANN performance

Online: 9 November 2023 (13:37:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0638.v1

Effect of Agro-Industrial Substrates Fermented with Lactic Acid Bacteria and Yeasts on the Intestinal Microbiota of Guinea Pigs (Cavia porcellus)

José Miranda Yuquilema, Juan Taboada, Verónica Once, Wilfrido Briñez

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: probiotic; production; intestinal health; performance; intestinal flora

Online: 9 November 2023 (13:36:32 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202311.0641.v1

The Immunogenicity of a Foot-and-Mouth Disease Virus Serotype O Vaccine in Commercial and Subsistence Cattle Herds in Zambia

Frank Banda, Anna B Ludi, Ginette Wilsden, Clare Browning, Lynnfield Mooya, Masuzyo Ngoma, Geoffrey M Muuka, Cornelius Mundia, Paul Fandamu, Henry L Kangwa, David J Paton, Donald P King, Melvyn Quan

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: foot-and-mouth disease; immunogenicity; vaccine; field evaluation

Online: 9 November 2023 (13:35:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0645.v1

Using Hydrological Models and Remote Sensing to Characterize Snow Pack Behaviour in High Mountain Environments

Jamal Hassan Ougahi, John Sibbald Rowan

Subject: Environmental And Earth Sciences, Geography Keywords: SWAT; snow water equivalent; global precipitation products; multi-variable calibration; remote sensing

Online: 9 November 2023 (13:34:15 CET)

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Seasonal snowpacks, characterized by their snow water equivalent (SWE), play a major role in the hydrological cycle, snow melt contributions to floods and the subsequent availability of water resources downstream. Accurately estimating SWE and understanding its spatial and temporal variations presents a considerable challenge, particularly within mountainous regions characterized by complex terrain and limited observational data. Seeking to enhance the performance of the widely used Soil and Water Assessment Tool (SWAT), we report a new approach characterising snowpack behaviour incorporating both modelled and remotely sensed derived SWE calibration data. We focus on the Chenab River Basin (CRB) a headwater catchment of the Indus Basin, globally significant in terms of human inhabitants and intensifying flood risk due to climate change. We conducted a thorough assessment of five satellite-derived and reanalysis-based precipitation datasets: ERA5-Land, CMORPH, TRMM, APHRODITE, and CPC UPP. This reveals significant levels of uncertainty in global precipitation products when compared to reference data from observed stations as well as in the resulting simulated streamflow from the SWAT model. Subsequently, we expanded the scope of the SWAT model to encompass the spatial and temporal simulation of SWE. This was achieved by incorporating information from remotely sensed and modelled SWE products, manually adjusting snow parameters in R-SWAT for both the main basin and at sub-basin scales. Integrating SWE from reference snow products into the calibration process, alongside streamflow data, substantially enhanced modelling accuracy to simulate SWE compared to the conventional auto-calibration and single-variable approaches reliant solely on streamflow data. This approach results in considerable improvement in SWE predictions and to some extent in streamflow simulation in catchments dominated by snow. This research highlights the potential of remote sensing and modelled SWE parameterisation in the absence of in-situ snowpack data in high-altitude environments. An improved understanding of SWE behaviour is vital for predicting hydrological responses spanning hazards to water resources in the populous downstream regions of the Indus Basin, especially in the face of climate change.

Preprint REVIEW | doi:10.20944/preprints202311.0642.v1

Exploring the Potential of Nanotechnology in Cosmetics: Incorporating Natural Ingredients for Enhanced Skin Benefits

Elçin Tören, Baturalp Yalçınkaya, Matěj Buzgo

Subject: Chemistry And Materials Science, Biomaterials Keywords: nanotechnology; nanofibers; active ingredients; skincare products; encapsulation methods; electrospinning

Online: 9 November 2023 (13:32:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0636.v1

Value Cocreation and Digital Financial Services Inclusion in Emerging Markets

Esi Elliot, Ben Ngugi, Russell Adams, Clara Downey

Subject: Business, Economics And Management, Business And Management Keywords: value cocreation; digital; financial inclusion; emerging Markets; financial Services

Online: 9 November 2023 (11:48:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0635.v1

Embedded Spatial-Temporal Convolutional Neural Network Based on Scattered Light Signals for Fire and Interferential Aerosols Classification

Fang Xu, Ming Zhu, Mengxue Lin, Maosen Wang, Lei Chen

Subject: Physical Sciences, Optics And Photonics Keywords: Embedded spatial-temporal convolutional neural network (EST-CNN); aerosols classification; fire smokes; interferential aerosol

Online: 9 November 2023 (11:46:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0637.v1

Fostering Resilience and Wellness: The Synergy of Mindful Eating and the Mediterranean Lifestyle

Efstratios Christodoulou, Georgia-Eirini Deligiannidou, Christos Kontogiorgis, Constantinos Giaginis, Antonios Ε. Koutelidakis

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Mindful eating, Mediterranean lifestyle; psychological resilience; mindfulness; obesity

Online: 9 November 2023 (11:45:40 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202311.0615.v1

A Study to Determine the Prevalence and Risk Factors of Schistosomiasis Amongst School-Aged Children in Low- and Middle-Income Communities: Ehlanzeni District Municipality, South Africa

Sunnieboy Lot Njikho, Vanessa Cecilia Quan, Thokozani Patrick Mbonane, Renay Helouise Van Wyk

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: schistosomiasis; prevalence; district municipality; disease; risk factors; low- and middle-income community; environmental factors

Online: 9 November 2023 (11:26:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0612.v1

Superelsatic SMA Honeycomb Damper for Seismic Protection of Bridges

Sasa Cao, Luwei Liu, Fulong Hu, Guixin Zhang

Subject: Engineering, Civil Engineering Keywords: Superelstic SMA; honeycomb damper; geometrical nonlinear property; long-stroke; thickness of walls

Online: 9 November 2023 (11:25:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0621.v1

Occurrence of Picobirnavirus in Domestic and Wild Animals from Three Cities of Brazilian Amazon

Elaine Hellen Nunes Chagas, Julia Rezende Da Silva, Bruno de Cássio Veloso de Barros, José Wandilson Barboza Duarte Júnior, Fabiolla da Silva dos Santos, Edivaldo Costa Sousa Júnior, Delana Andreza Melo Bezerra, Helder Henrique Costa Pinheiro, Ceyla Maria Oeiras de Castro, Yashpal Singh Malik, Joana D’Arc Pereira Mascarenhas

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: enteric virus; picobirnavirus; brazilian animals; page, rt-pcr; rdrp gene; phylogenetic analysis; genogroup I

Online: 9 November 2023 (11:24:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0639.v1

Critical Sample Size Analysis on Uncertainty Aerodynamic Evaluation for Compressor Blade With Stagger Angle Errors

Haohao Wang, Limin Gao, Baohai Wu

Subject: Engineering, Aerospace Engineering Keywords: compressor blade; manufacturing uncertainty; stagger angle; uncertainty quantification; limited samples; polynomial chaos

Online: 9 November 2023 (11:23:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0611.v1

Plasma-Chemical Disposal of Silicon and Germanium Tetrachlorides Waste by Hydrogen Reduction

Roman Kornev, Igor Gornushkin, Lubov Shabarova, Alena Kadomtseva, Georgiy Mochalov, Nikita Rekunov, Sergey Romanov, Vitaly Medov, Darya Belousova, Nikita Maleev

Subject: Chemistry And Materials Science, Chemical Engineering Keywords: high-frequency arc discharge; hydrogen reduction; silicon chlorides; germanium chlorides

Online: 9 November 2023 (11:20:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0620.v1

Self-efficacy, Vulnerability to Stress and Anxiety, Psychological Factors Involved in Arterial Hypertension

Lucia BUBULAC, Maria-Cristina BURUNTIA

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: self-efficacy; stress-vulnerability; perceived stress; anxiety; hypertension

Online: 9 November 2023 (11:17:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0614.v1

3D Object Detection Using Multiple Frame Proposal Features Fusion

Minyuan Huang, Henry Leung, Ming Hou

Subject: Engineering, Electrical And Electronic Engineering Keywords: autonomous driving; 3D object detection; multiple frame point clouds; feature and data fusion

Online: 9 November 2023 (11:16:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0617.v1

Modelling Habitat Suitability of Luciola cruciata Based on Local Landscape Features

Tomoya Ogami, Shinji Fukuda, Hirofumi Kakudo, Roy Sidle

Subject: Environmental And Earth Sciences, Ecology Keywords: habitat suitability; data-driven model; artificial light at night; riparian habitat; firefly

Online: 9 November 2023 (11:13:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0619.v1

Drainage Performance of Long Longitudinal Slope and High Safety Permeable Asphalt Pavement

Haocheng Liu, Bin Xu, Hongshan Wang, Aodong Gao, Xuefeng Yu, Shujiang Ping, Shiqing Zhang

Subject: Engineering, Civil Engineering Keywords: long longitudinal slope; permeable pavement; porosity; road performance

Online: 9 November 2023 (11:12:47 CET)

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Permeable asphalt pavement refers to an asphalt mixture layer with an air void content of more than 18% and internal water permeability and drainage capabilities, which can quickly drain away water on the road surface, improve rainy day travel safety and ride comfort. This paper aims to explore the optimal asphalt mixture mix design for long longitudinal slope roads. By using CT scanning technology to analyze the air void content of different rotated and compacted asphalt mixture specimens, and extensively testing and evaluating the performance of permeable pavement mixtures, the following conclusions are drawn: Based on the research philosophy of functional integration, a new asphalt mixture gradation suitable for long longitudinal slope roads is proposed, with the optimal key factor composition being: 0.075mm passing rate of 7%, 2.36mm passing rate of 20%, 9.5mm passing rate of 55%, and oil-stone ratio of 4.8%. The FAM mixture was divided into three parts for air void analysis, with the upper part having a slightly higher air void content than the lower part. The air void distribution diagram of the FAM mixture is concave, with higher air void rate curves on both sides and a lower middle curve. Compared with laboratory dry measurement method, CT scanning test showed slightly higher air void content in specimens. Through dynamic modulus testing, the strength requirement for road asphalt mixture in pavement structure design was evaluated. It was found that at high temperature conditions (50℃), the minimum dynamic modulus value of the FAM mixture was 323 MPa, with a peak value of 22746MPa at a temperature of -10℃ and a frequency of 25HZ. The dynamic modulus value at high temperature conditions is lower than at low temperature conditions, while the dynamic modulus value at high frequency conditions is higher than at low frequency conditions. This study provides useful information and experimental data for the design of new asphalt mixtures for long longitudinal slope roads, and has conducted in-depth research on the air void distribution and performance of the mixture, providing strong support for related research fields and practical applications.

Preprint ARTICLE | doi:10.20944/preprints202311.0632.v1

Preparation and Characterization of Conductive/Self-Healing Resin Nanocomposites Based on Tetrafunctional Furan-Functionalized Aniline Trimer Modified Graphene

Feng Wang, Yichuan Zhang, Su Hu, Xiangyu Zhong, Jiangbo Bai, Yang Zhang, Jianwen Bao

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: nanocomposites; graphene; DA reaction; self-healing; electrical conductivity

Online: 9 November 2023 (11:07:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0628.v1

Multiplex Avidity Assay for Evaluating Thyroid Autoantibodies

Elena Savvateeva, Vera Sokolova, Marina Yukina, Nurana Nuralieva, Elena Kulagina, Maria Isaeva, Ekaterina Troshina, Dmitry Gryadunov

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: avidity; avidity index (AI); thyroid autoantibodies; protein microarray; multiplex assay; immunoassay

Online: 9 November 2023 (11:05:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0630.v1

Optimal Planning of Urban Building-type Integrated Energy Systems Considering Indoor Somatosensory Comfort and PV Consumption

Guangzeng You, Peng Sun, Yi Lei, Donghuizhang Zhang, Haibo Li

Subject: Engineering, Energy And Fuel Technology Keywords: Integrated energy systems (IES); Buildings, Optimization; Indoor somatosensory comfort; PV consumption

Online: 9 November 2023 (11:04:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0629.v1

Intelligent Space Object Detect Driven by Space Object Data

Qiang Tang, Xiangwei Li, Meilin Xie, Jialiang Zhen

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: space object identification; deep learning; YOLO; deformable convolution

Online: 9 November 2023 (11:00:23 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.0623.v1

Defending the Digital Frontier: IDPS and the Battle Against Cyber Threat

Hamza Azam, Mohammad Irfan Dulloo, Muhammad Hassan Majeed, Janelle Phang Hui Wan, Lee Tong Xin, Muhammed Ahnaf Tajwar, Siva Raja Sindiramutty

Subject: Computer Science And Mathematics, Computer Science Keywords: Intrusion Prevention System (IPS); Intrusion Detection System (IDS); Intrusion Detection and Presentation System (IDPS); Deep Packet Inspection (DPI); Network-Based Prevention System (NIPS)

Online: 9 November 2023 (10:59:26 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.1913.v3

Design of Photovoltaic System for Green Manufacturing by using Statistical Design of Experiments

Debo Brata Paul Argha, Md Ashik Ahmed

Subject: Engineering, Civil Engineering Keywords: Solar PV system; Regression Model; DOE; Solar energy; Fossil fuels

Online: 9 November 2023 (10:58:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0605.v1

Interpretation of Gravitational Data from Past Martian Missions

Vincent Affatato

Subject: Engineering, Aerospace Engineering Keywords: Mars; Geophysics; Bouguer; Gravity Models; Planetary Interiors; Crustal Variations

Online: 9 November 2023 (10:55:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0634.v1

Satisfaction Level of the Academic Community with the Implementation of WEB-Based SIAKAD IAKN Tarutung (Comparison: Implementation of SIAKAD UIN-Sumatera Utara)

Sudirman Lase, David Fero, Apriliana Lase, Herlina Saragih

Subject: Social Sciences, Education Keywords: SIAKAD; Implementation; SERVQUAL; Satisfaction; Academic community

Online: 9 November 2023 (10:18:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0633.v1

Trend Patterns of Melanoma Skin in Serbia from 1999 to 2020

Natasa K Rancic, Danica B Tiodorovic, Mirko V Ilic, Biljana N Kocic, Natasa S Maksimovic, Ilija D Kocic, Dusan P Miljkovic, Suzana A Otasevic

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: incidence; trend; melanoma of the skin

Online: 9 November 2023 (10:17:20 CET)

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Trend patterns of melanoma skin in Serbia from 1999 to 2020 *Rancic K. Natasa 1,2, Tiodorovic B. Danica 1,4, Ilic V. Mirko 2, Biljana N. Kocic 1,2, Maksimovic S. Natasa 3, Ilija D. Kocic 4, Dusan P. Miljkovic 4, Otasevic A. Suzana 1,2 Introduction. Melanoma of the skin represents about 1% of all skin cancers and it causes nearly 80% of skin cancer deaths. Due to its increasing incidence, particularly in the most developed countries it represents a great challenge for primary prevention. Objective. To explore patterns and analyze incidence trends of melanoma in Central Serbia from 1999 to 2020. Materials and Methods. Descriptive study was done and data were obtained from the Population-based Cancer Registry of Serbia. The joinpoint regression analysis was done to assess the incidence trend of the melanoma skin: the annual percent change (APC) along with its 95% confidence interval (95% CI) was calculated. Results. A total number of 9952 new melanoma cases were registered melanoma (5204 in males and 4748 in females) during the observed period. Males represented 52.3% of all patients, with male to female ratio of incidence 2.09:1. A non significant increasing trend of incidence in males from 1999 to 2013 with APC of 2.53% (95%CI: from -18.2 to 21.9, p=1) and significantly increasing trend from 2013 to 2020 with the APC of 11.29 % (95%CI: from 1.4 to 5.8, p<0.001) was established. An incidence trend in females has stabilized in the whole studied period, with APC of 0.42% (95%CI: from -3.3 to 6.8, p=0.1). Melanoma of the skin was not common before the age of 30. Out of all cases and about of 76% new cases were diagnosed in persons ≥ 50 years of age. Conclusion. The incidence trend of new melanoma cases significantly increase in the whole population from 1999 to 2020. The significant increasing of incidence trend in males and stabilization of incidence trend in females was established. Males had significantlly higher incidence rates than femalesand over of 76% new melanoma cases were diagnosed in persons above 50 years of age.

Preprint ARTICLE | doi:10.20944/preprints202311.0627.v1

Relative Comparison of Benefits of Floor-Slab Insulation Methods, Using Polyiso and XPS Materials in South Africa, Subject to the New National Building Energy Efficiency Standards

Emmanuel Kizito Kabundu, Sijekula Mbanga, Brink Botha, Emma Ayesu-Koranteng

Subject: Engineering, Architecture, Building And Construction Keywords: Energy efficiency; Lifecycle analysis (LCA); Embodied energy; Source energy; Site energy; Energy savings; Energy payback period.

Online: 9 November 2023 (10:13:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0626.v1

Two Plastid Genome Sequences of the Belian (Eusideroxylon zwageri): Comparative Analysis and Phylogenetic Relationships with Other Magnoliids

Zhu Wen, Tan Yun Hong, Zhou Xin Xin, Song Yu, Xin Pei Yao

Subject: Biology And Life Sciences, Plant Sciences Keywords: chloroplast genome; comparative genomics; Eusideroxylon; Lauraceae; phylogenetic relationships

Online: 9 November 2023 (10:11:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0631.v1

(Nano)granules Involving Aggregation at a Passage to the Nanoscale as Viewed in Terms of Diffusive Heisenberg Relation

Adam Gadomski

Subject: Physical Sciences, Chemical Physics Keywords: matter aggregation; mesoscale; nanoscale; granule evolution; stochastic quantization; quantum-size effect; Heisenberg type relation for the granule evolution; Fokker-Planck and diffusion type equation; nanostructure formation

Online: 9 November 2023 (10:10:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0622.v1

Modification of Oxygen Production of Algal Cells in the Presence of O-chlorobenzylidene Malononitrile, Biodegradation in the Eco-Friendly Way

Viorel Gheorghe, Catalina Gabriela Gheorghe, Daniela Roxana Popovici, Sonia Mihai, Dragomir Raluca Elena, Raluca Şomoghi

Subject: Environmental And Earth Sciences, Environmental Science Keywords: CS gas; O-Chlorobenzylidene malononitrile; ecotoxicity; chlorophyll; FTIR; SEM spectroscopy

Online: 9 November 2023 (10:08:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0625.v1

Decreased Volumes of Selected Cortical and Limbic Structures of the Brain Are Associated with Post-stroke Cognitive and Affective Disorders: Multiple Hit Scenarios?

Marina Y Zhanina, Tatyana A Druzhkova, Nikolay V Ierusalimsky, Elena E Vladimirova, Natalia N. Eremina, Alla B. Guekht, Natalia V. Gulyaeva

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: ischemic stroke; MRI; morphometry; post-stroke cognitive impairment, post-stroke depressive disorder; cortisol; α-amylase; interleukin-6; multiple hit hypothesis; hypothalamic-pituitary-adrenal axis; sympathoadrenal system

Online: 9 November 2023 (10:06:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0624.v1

A Traceability Platform for Monitoring Environmental and Social Sustainability in the Textile and Clothing Value Chain: Towards a Digital Passport for T&C

Luis Alves, Miguel Sá, Estrela Ferreira Cruz, Toni Alves, Marcelo Alves, João Oliveira, Manuel Santos, António Miguel Rosado Da Cruz

Subject: Engineering, Control And Systems Engineering Keywords: Textile and Clothing Value Chain; Blockchain-based Traceability Platform; Environmental and Social Indicators; Environmental and Social Impact Score; Sustainable and Cleaner Production

Online: 9 November 2023 (10:05:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0585.v1

Effect of Spindle Speed and Feed Rate on Surface Roughness and Milling Duration in Fabrication of the Milled Complete Dentures: An In Vitro Study

Yo Akiyama, Maiko Iwaki, Yuriko Komagamine, Shunsuke Minakuchi, Manabu Kanazawa

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: CAD/CAM; milled denture; surface roughness; spindle speed; feed rate; fabrication time

Online: 9 November 2023 (09:14:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0576.v1

Acute Effect of Positive Airway Pressure on Heart Rate Variability in Obstructive Sleep Apnea

Ji Hye Shin, Min Ji Song, Ji Hyun Kim

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Obstructive sleep apnea; heart rate variability; continuous positive airway pressure

Online: 9 November 2023 (09:13:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0616.v1

Discovery of Transfer Factors in Plant Source Proteins and In Vitro Assessment of Their Immunological Activities

Mesfin Yimam, Teresa Horm, Shengxin Cai, Alexandria O’Neal, Ping Jiao, Mei Hong, Thida Tea, Qi Jia

Subject: Biology And Life Sciences, Life Sciences Keywords: Transfer factor; Natural Killer cells; plant proteins; immune support; Brassica juncea; Raphanus sativus

Online: 9 November 2023 (08:45:42 CET)

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Repeated exposure to pathogens leads to evolutionary selection of adaptive traits. Many species transfer immunological memory to their offspring to counteract future immune challenges. Transfer factor such as that found in colostrum is among the many mechanisms where transfer of immunologic memory from one generation to the next can be achieved for enhanced immune response. Here, a library of 100 plants with high protein contents were screened to find plant-based proteins that behave like a transfer factor moiety to boost human immunity. Aqueous extracts from candidate plants were tested on a human peripheral blood mononuclear cell (PBMC) cytotoxicity assay using human cancerous lymphoblast cells - K562 cells as a target and Natural Killer cells as an effector. Plant extracts that caused PBMCs to exhibit enhanced killing beyond the capability of the colostrum-based transfer factor were considered hits. Primary screening yielded an 11% hit rate. Protein content of these hits were tested by Bradford Assay and Coomassie stained-SDS-PAGE, where three extracts were confirmed to have high protein contents. Plants with high protein contents underwent C18 column fractionation using methanol gradients followed by membrane ultrafiltration to isolate proteins with molecular weight <3 kDa, 3-30 kDa, and >30 kDa fractions. It was found that the 3-30 kDa and >30 kDa fractions had high activity in the PBMC cytotoxicity assay. The 3-30 kDa ultrafiltrates from the top two hits, seeds from Raphanus sativus and Brassica juncea, were then selected for protein identification by mass spectrometry. The majority of the proteins in the fractions were found to be seed storage proteins, with low abundance of proteins involved in plant defense and stress response. These findings suggest that Raphanus sativus or Brassica juncea extracts could be considered for further characterization and immune functional exploration with a possibility of supplemental use to bolster recipients’ immune response.

Preprint ARTICLE | doi:10.20944/preprints202311.0618.v1

Identification of Myofascial Trigger Point Using the Combination of Texture Analysis in B-mode Ultrasound with Machine Learning Classifiers

Fatemeh Shomal Zadeh, Ryan G.L. Koh, Banu Dilek, Kei Masani, Dinesh Kumbhare

Subject: Physical Sciences, Acoustics Keywords: Myofascial Trigger Point; Texture Features; Machine Learning; Ultrasound

Online: 9 November 2023 (08:44:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0613.v1

Process Optimization, Genetic Programming Modeling and Reliability Assessment of Bioactive Extracts Recovery From Phyllantus Emblica

Hamdan Alanzi, Hamoud Alenezi, Oladayo Adeyi, Abiola J. Adeyi, Olusola Emmanuel, Chee-Yuen Gan, Olusegun Abayomi Olalere

Subject: Engineering, Chemical Engineering Keywords: Phyllantus emblica leaf; bioactive extract; heat-assisted technology; multi gene genetic programming; reliability assessment

Online: 9 November 2023 (07:54:45 CET)

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The feasibility of recovering bioactive antioxidants from Phyllantus emblica leaves using ethanol -water mixture (0 – 100%) and heat-assisted extraction technology (HAE-T) was investigated in this present study. To this effect, the process parameter of operating temperature (OT: 30 -50 oC), solid -to-liquid ratio (S:L: 1:20 - 1:60 g/mL) and extraction time (ET: 45 - 180 min) were investigated on the extract total phenolic content (TPC, mg GAE/g d.w), yield (EY, %) and antioxidant activity (μM AAE/g d.w) by employing the Box-Behnken experimental design (BBD) available in response surface methodology (RSM). Multi-objective process optimization using the desirability function algorithm to determine set of process variables that simultaneously optimize process responses of TPC, EY and AA was also investigated. The recovery process was thereafter modeled with BBD-RSM and multi gene genetic programming (MGGP) algorithm and model reliability assessment via Monte Carlo simulation were conducted for the best performing set of models for predicting TPC, EY and AA values. The HPLC characterization of the recovered extract was carried out to ascertain the phenolic compound constituents of the Phyllantus emblica leaf extract. The 50% ethanol solution was found to be the best for the optimal extraction of antioxidants from Phyllantus emblica leaves. The HAE-T was suitable for recovering bioactive extract from Phyllantus emblica leaves and investigated process parameters have impacts on the recovery process. The process parameters that simultaneously gave the optimum EY of 21.6565%, TPC of 67.116 mg GAE/g and AA of 3.68583 µM AAE/g were OT of 41.61 oC, S:L of 1:60 g/mL and ET of 180 min. The HPLC extract profiling revealed that the bioactive constituents present in the recovered extract were betulinic acid, gallic acid, chlorogenic acid, caffeic acid, ellagic acid, and ferulic acid. Both the developed BBD-RSM and evolved MGGP-based models predicted the observed process response of TPC, EY and AA satisfactorily with BBD-RSM models marginally better in their predictions. The reliability results showed that the BBD-RSM models predicted TPC, EY and AA values with high certainty of 99.985%, 97.569% and 98.661%, respectively.

Preprint ARTICLE | doi:10.20944/preprints202311.0610.v1

Electrochemical Synthesis of Functionalized Graphene/Polyaniline Composite Using Two Electrode Configuration for Supercapacitors

Dong Sheng Yu, Jili Li, Tiekun Jia, Binbin Dong, Zhixiao Han, Wenjie Tian, Ruilin Jiang, Xi Lu, Lekang Li, Nam Hoon Kim, Joong Hee Lee

Subject: Chemistry And Materials Science, Electrochemistry Keywords: aryl diazonium salt-functionalized graphene (ADS-G); ADS-G/PANI composites; electrochemical polymerization; supercapacitor

Online: 9 November 2023 (07:52:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0582.v1

Advantages of Long Wavelength Photosensitizer meso-Tetra(3-Pyridyl) Bacteriochlorin in Therapy of Bulky Tumors

Ekaterina A. Plotnikova, Elena Nemtsova, Maxim A. Abakumov, Andrei Pankratov, Peter Shegai, Andrey Kaprin

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: photodynamic therapy; photosensitizer; bacteriochlorins; photocytotoxicity; photoinduced antitumor activity; cell; tissue; tumor

Online: 9 November 2023 (07:49:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0579.v1

Strength Development of Metakaolin-Based Alkali-Activated Cement

Baowen Lou, Torbjørn Vrålstad

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Alkali-activated materials; geopolymer; metakaolin; well cement; co-binder

Online: 9 November 2023 (07:48:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0596.v1

Bicarbazole-Benzophenone Based Twisted D-A-D Derivatives as Blue Emitters for Highly Efficient Fluorescent OLEDs

Dovydas Blazevicius, Iram Siddiqui, Prakalp Gautam, Gintare Krucaite, Daiva Tavgeniene, Mangey Ram Nagar, Krishan Kumar, Subrata Banik, Jwo-Huei Jou, Saulius Grigalevicius

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Donor-acceptor-donor (D-A-D) derivatives; blue organic light emitting diode (OLED); high efficiency; blue emission; thermal analysis

Online: 9 November 2023 (07:48:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0583.v1

Spermine Oxidase-Substrate Electrostatic Interactions: The Modulation of Enzyme Function by Neighboring Colloidal Ɣ-Fe₂O₃

Graziano Rilievo, Massimiliano Magro, Federica Tonolo, Alessandro Cecconello, Lavinia Rutigliano, Aura Cencini, Simone Molinari, Maria Luisa Di Paolo, Cristian Fiorucci, Marianna Nicoletta Rossi, Manuela Cervelli, Fabio Vianello

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Nanoenzyme; Spermine oxidase; Enzyme activity; Electrostatic interactions; Ionic strength; Enzyme nano-immobilization

Online: 9 November 2023 (07:46:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0586.v1

Exploration of Microalgae-Activated Sludge (Mas) Growth Performance in Lab-Scale Photobioreactor at Outdoor Environmental Condition for Wastewater Biotreatment

Abraham Olamilekan James, Abayomi Oluwatobiloba Bankole, Caroline Moço Erba Pompei, Gustavo Alencar Silva Almeida Dantas, Graziele Ruas, Gustavo Henrique Ribeiro Da Silva

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: Microalgae-Activated Sludge; Nutrients recovery; Pollutant removal; Total Coliform and Escherichia coli removal

Online: 9 November 2023 (07:45:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0595.v1

Effects of Multidisciplinary Biopsychosocial Rehabilitation on Short-Term Pain and Disability in Chronic Low Back Pain: A Systematic Review with Network Meta-Analysis

Ivan Jurak, Kristina Delaš, Lana Erjavec, Janez Stare, Igor Locatelli

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: chronic low back pain; multidisciplinary biopsychosocial rehabilitation; exercise therapy; network meta-analysis

Online: 9 November 2023 (07:44:33 CET)

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Chronic Low Back Pain (CLBP), defined as pain persisting for at least 12 weeks, is a significant public health issue, with prevalence intensifying due to an ageing global population, amassing approximately 619 million cases in 2020 and projected to escalate to 843 million by 2050. Given the multitude of therapeutic modalities available for CLBP, this research sought to ascertain their respective efficacies in ameliorating pain and disability. We specifically scrutinized Multidisciplinary Biopsychosocial Rehabilitation (MBR) among adults enduring non-specific low back pain for over 12 weeks, excluding acute pain conditions and pre-study surgical interventions. MBR is an approach encompassing various modalities, including exercise, behavioral therapies, educational programs, and work conditioning aspects, necessitating a comprehensive Network Meta-Analysis (NMA) to fully grasp the extensive scope of its impact. The constructed network comprised diverse MBR modalities (behavioral, educational, and work conditioning) alongside exercise therapy (ET), minimal intervention, and usual care, serving as controls with pain and disability as outcomes. Through the analysis of 4,619 initially identified studies, 93 were included, encompassing a total of 8,059 participants. The NMA conducted substantiated that both ET and MBR modalities were notably effective in alleviating CLBP, with education-oriented MBR emerging as the most efficacious for pain mitigation and behavior-focused MBR for disability reduction. Nevertheless, the discerned differences amongst the treatments were minimal and uncertain, highlighting that no modality was definitively superior to the others. The analysis revealed low global and local inconsistency within the network, underscoring the reliability of the observed outcomes. Given the intricate nature of CLBP, embodying various facets, our findings advocate for a combined therapeutic approach to optimize treatment efficacy. Nonetheless, the presence of high study heterogeneity and potential biases necessitates cautious interpretation of the results, prompting future research.

Preprint ARTICLE | doi:10.20944/preprints202311.0594.v1

In situ SAXS-WAXS Temperature Evolution Study of the Nanostructure of Self-Reinforced Ultra High Molecular Weight Polyethylene (UHMWPE)

Eugene S. Statnik, Yulia E. Gorshkova, Alexey I. Salimon, Dmitry D. Zherebtsov, Sergey D. Kaloshkin, Alexander M. Korsunsky

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Self-reinforced composite (SRC); Ultra-high Molecular Weight Polyethylene (UHMWPE); in situ heating; nanostructure; SAXS-WAXS; Shape Memory Effect (SME)

Online: 9 November 2023 (07:44:07 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.0588.v1

Advances of Protein Palmitoylation in Tumor Cell Deaths

Xiangyi Lin, Yuxuan Shi, Yuxin Zhan, Yuying Xing, Yu Li, Zhiqing Zhou, Guoan Chen

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: protein palmitoylation; apoptosis; autophagy; ferroptosis; pyroptosis

Online: 9 November 2023 (07:43:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0590.v1

Efficiency and Vulnerability in Networks. A Game Theoretical Approach

Conrado M. Manuel, Eduardo Ortega

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: Game theory; TU-game; Efficiency; Vulnerability, Networks; Communication situation; Myerson value

Online: 9 November 2023 (07:34:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0603.v1

Beacon Success Rate versus Gateway Density in Sub-GHz Sensor Networks

Başak Can, Bora Karaoğlu, Srikar Potta, Franklin Zhang, Artur Balanuta, Muhammed Faruk Gencel, Uttam Bhat, Johnny Huang, Pooja Patankar, Shruti Makharia, Radhakrishnan Suryanarayanan, Arvind Kandhalu, Vinay Sagar Krishnamurthy Vijaya Shankar

Subject: Engineering, Electrical And Electronic Engineering Keywords: beacon collision; beacon interval; Carrier-to-Interference ratio; frequency hopping; gateway; GFSK; Internet of Things (IoT); IEEE 802.15.4; latency; Wide Area Network (WAN); sensors

Online: 9 November 2023 (07:33:06 CET)

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Multiple Gateways (GWs) provide network connectivity to Internet of Things (IoT) sensors in a Wide Area Network (WAN). The End Nodes (ENs) can connect to any GW by discovering and acquiring its periodic beacons. This provides GW diversity and hence improves coverage. If the GWs are within vicinity to each other, and they keep sending periodic beacons to be discovered, the result is interference and collisions. In this study, the impact of such intra-network interference is analyzed to determine the maximum number of GWs that can co-exist within a given urban neighborhood. The paper shows the relationship between beacon collisions and the resulting packet loss rates in a given urban environment. The expected collision rates are calculated for the Medium Access Control (MAC) layer. The eventual packet loss rates are calculated with the MAC and Physical (PHY) layers combined. For this purpose, a new co-channel interference model is presented. The model calculates the average Carrier to Interference ratio (C/I) averaged across all the colliding events. It takes into account the partial overlap durations and the relative power of each colliding signal. The model shows that a collision does not always cause a packet loss. Packet losses occur if there is a collision and if the C/I is below a threshold. The performance evaluation is presented using a combination of analytical and simulation methods. The analytical methods provide the theoretical foundation, and have been used to validate the simulation results. Furthermore, the system models are developed from experimental data obtained from measurements with real hardware. Numerical results are provided with a low bit rate Gaussian Frequency Shift Keying (GFSK) modulation at the PHY layer, which is derived from the IEEE 802.15.4 standard specification. This paper provides guidance on selecting the right GFSK modulation parameters for such low bit-rate and narrow bandwidth IoT applications. The analysis and simulation results show that larger beacon intervals help in reducing beacon loss rates, at the cost of larger beacon acquisition latency. On the flip side, the gateway discovery latency reduces with increasing GW density thanks to abundance of beacons.

Preprint ARTICLE | doi:10.20944/preprints202311.0601.v1

Virtual Reality Videos for Delivery of Extension Educational Materials on Manure and Mortality Management: A Pilot-Study

Danadhi Gunawardana, Xiao Wang, Amirhossein Mahdaviarab, OP McCubbins, Rafael Landaverde, Zong Liu

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: Extension; Manure; Mortality; Management; Virtual Reality

Online: 9 November 2023 (07:31:38 CET)

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This study presents virtual reality (VR) videos as an effective technique for delivering extension educational materials on manure and mortality management. Virtual reality is a technology that can enable immersive distance learning. Using VR tours can enable the public to learn manure and mortality management technologies without in-person farm visits, thus saving traveling time and money and avoiding exposure to pathogens and noxious odors in farms. As the first part of this project, 360° VR tours were created on multiple aspects of manure management, including composting, anaerobic digestion, and preliminary wastewater treatment. These videos were presented to a diverse audience of agricultural producers, extension specialists, and researchers through in-person and online extension events and the Texas Manure YouTube channel. The effectiveness of videos was evaluated using surveys, which measured the audience's awareness of the topics before and after watching VR videos. Statistical analysis revealed that the increase in awareness after watching the videos was statistically significant, with a p-value of less than 0.0001. Statistical analysis also revealed that job classification and professional experience significantly impacted the change in awareness. Researchers, extension specialists/agents, and participants with less experience in manure and mortality management experienced a greater change in awareness than agricultural producers and participants with more experience. Interest and impression of the audience on the VR videos was also evaluated. According to survey data, the majority of the audience rated these videos as an effective technique for educating the public about manure and mortality management, found the VR videos interesting, were willing to learn more content through VR videos, and were likely to recommend them to their colleagues. A statistically significant correlation could be observed between the awareness change and the effectiveness rating given to the videos by the participant.

Preprint ARTICLE | doi:10.20944/preprints202311.0577.v1

Retaining Non-EU Immigrants in Rural Areas to Sustain Depopulated Regions: Motives to Remain

Elisete Simoes Diogo

Subject: Social Sciences, Other Keywords: International immigrants; Rural Areas; Depopulated regions; Keeping people in Low density territories; Regional development

Online: 9 November 2023 (07:30:11 CET)

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Rural areas, as a system, face multiple challenges. Among these are population decline and attendant economic and social maladies namely demographic issues considering a scarce population. Pull factors for immigrants to go to other countries are known, nevertheless, to comprehend factors for remaining in rural areas after arriving could support a strategic local policy, and for an informed practice. The purpose of the study is to explore motivations shaping immigrants’ intentions to stay in the Alentejo, a depopulated region in Portugal, using a qualitative approach. Research questions are: What motivates immigrants to remain living in depopulated regions in Portugal? Furthermore, what contributions can practitioners and immigrants give for local policy and practice? Eight practitioners and fifteen non-European Union immigrants living in this region were interviewed between 2020 and 2021. Empirical data were analysed, supported by MaxQDA software. Results point out that the intention to remain in rural areas arise from a progressive construction, it is a process that immigrants experience to become motivated to stay long-term. Factors influencing the process include four components: 1. instrumental and material motivations; 2. emotional and social motivations; 3. motivations based on quality of life; and 4. motivations based on political dimensions. Components are conditioned by the availability of : stable and suitable jobs, access to decent and affordable housing, as well as quality of education and health services for their children; additionally to socio-emotional satisfaction, as family reunification, migrants network, integration and real intercultural living in the host community, close relationships to practitioners from social services; and quality of life, such as lower rents, peaceful and secure living conditions, granted a better future for their children as in any another place in Europe, associated finally to the simplified policy enabling one to become a legal citizen. Conclusions highlight implications for policy and practice, suggesting more investment for rural regions to reverse depopulation reality.

Preprint REVIEW | doi:10.20944/preprints202311.0587.v1

Women of Color in the Health Professions: A Scoping Review of the Literature

Olihe Okoro, Omolayo Umaru, Meghana Ray

Subject: Social Sciences, Gender And Sexuality Studies Keywords: Intersectionality; Healthcare professions; Women of color; Pharmacy; Racial/Ethnic inequity; Gender inequity; Discrimination; Professional advancement; Underrepresentation

Online: 9 November 2023 (07:29:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0602.v1

First Report and Pathogenicity of Vibrio campbellii (VC_AHPND) Isolated in South Korea

Hee-Jae Choi, Da-Yeon Choi, Ji-Hoon Lee, Jun-Hwan Kim, Yue Jai Kang

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Acute hepatopancreatic necrosis disease; Vibrio parahaemolyticus; Vibrio campbellii; Litopenaeus vannamei

Online: 9 November 2023 (07:29:12 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.0584.v1

Nurturing the Positive Mental Health of Autistic Children, Adolescents and Adults alongside That of Their Familycare-Givers: A Scoping Review of Reviews

Roy McConkey

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Autism; Autistic; Mental health; emotional wellbeing; family caregivers; Low and middle in-come countries; review; international

Online: 9 November 2023 (07:29:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0578.v1

Different Inhibition Mechanism of Atorvastatin, Olmesartan, and Resveratrol in Experimental Pathological Myofibroblast Heart Valve Model

Achmad Lefi, Denny Suwanto, Budi Baktijasa Dharmadjati, Yudi Her Oktaviono, Agus Subagjo, Oryza Sativa, Dita Aulia Rachmi, Ricardo Adrian Nugraha

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Myofibroblast; Atorvastatin; Olmesartan; Resveratrol; Valvular Interstitial Cell

Online: 9 November 2023 (07:28:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0580.v1

Pregnancy Outcomes in Patients with Urosepsis and Uncomplicated Urinary Tract Infections- a Retrospective Study

Viorel-Dragos Radu, Petronela Vicoveanu, Alexandru Cărăuleanu, Ana-Maria Adam, Alina-Sinziana Melinte-Popescu, Gigi Adam, Pavel Onofrei, Demetra Socolov, Ingrid-Andrada Vasilache, AnaMaria Harabor, Marian Melinte-Popescu, Ioana Sadiye Scripcariu, Elena Mihalceanu, Mariana Stuparu-Cretu, Valeriu Harabor

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: urinary tract infections; urosepsis; pregnancy; preterm birth; premature rupture of membranes

Online: 9 November 2023 (07:28:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0589.v1

Early Adverse Family Experiences and Elevated Adrenocorticotropic Hormone Predict Non-suicidal Self-Injury in Females with Non-psychotic Mental Disorders and Suicidal Ideation

Mikhail S. Zinchuk, Tatyana A Druzhkova, Sofya B. Popova, Marina Y. Zhanina, Alla B. Guekht, Natalia V. Gulyaeva

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: non-suicidal self-injury (NSSI); non-psychotic mental disorder; suicidal ideation; stress, hypothalamic-pituitary-adrenal (HPA) axis; cortisol; adrenocorticotropic hormone (ACTH); brain-derived neurotrophic factor (BDNF); early adverse experience

Online: 9 November 2023 (07:27:10 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.0572.v1

Family Business Research in Bangladesh: A Scoping Review and Direction for Research Opportunities

Moslehuddin Chowdhury Khaled, Tasnim Sultana, Tanbina Tabassum

Subject: Business, Economics And Management, Other Keywords: Family Business; Bangladesh; Review; Succession planning; Entrepreneurship; Small Business

Online: 9 November 2023 (07:26:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0581.v1

Achieving 2.2 GPA Ultra-High Strength in Low-Alloy Steel Using a Direct Quenching and Partitioning Process

Gang Niu, Donghao Jin, Yong Wang, Haoxiu Chen, Na Gong, Huibin Wu

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: 2.2 GPa ultra-high strength steel; TMCP-DQP process; martensite; retained austenite; mechanical properties

Online: 9 November 2023 (07:25:32 CET)

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Advanced high-strength steels (AHSS) have a wide range of applications in equipment safety and lightweight design, and enhancing the strength of AHSS to the ultra-high level of 2 GPa is currently a key focus. In this study, a new process of thermo-mechanical control process followed by direct quenching and partitioning (TMCP-DQP) is developed based on Fe-0.4C-1Mn-0.6Si (wt.%) low-alloy steel, and the effects of microstructure evolution on mechanical properties under TMCP-DQP process and conventional hot rolled quenched and tempered process (HR-QT) are comparatively studied. The results show that the TMCP-DQP process not only shortened the processing steps but also achieved outstanding comprehensive mechanical properties. The TMCP-DQP steel exhibits a tensile strength of 2.23 GPa, accompanied by 11.9% elongation and a Brinell hardness of 624 HBW, with an impact toughness of 28.5 J at -20 ℃. In contrast, the HR-QT steel exhibits tensile strengths ranging from 2.16 GPa to 1.7 GPa and elongations between 5.2% and 12.2%. The microstructure of TMCP-DQP steel primarily consists of lath martensite, containing thin-film retained austenite (RA), nanoscale rod-shaped carbides, and a minor number of nanoscale twins. The volume fraction of RA reaches 7.7%, with an average carbon content of 7.1 at.% measured by three-dimensional atom probe tomography (3DAP). Compared to the HR-QT process, the TMCP-DQP process results in finer microstructure, with a prior austenite grain (PAG) size of 11.91 μm, forming packets and blocks with widths of 5.12 μm and 1.63 μm. The TMCP-DQP process achieves the ultra-high strength of low-alloy steel through the synergistic effects of grain refinement, dislocation strengthening, and precipitation strengthening. The dynamic partitioning stage stabilizes the RA through carbon enrichment, while the relaxation stage reduces a small portion of the dislocations generated by thermal deformation, and the self-tempering stage eliminates internal stresses, all guaranteeing considerable ductility and toughness. The TMCP-DQP process may offer a means for industries to streamline their manufacturing processes and provide a technological reference for producing 2.2 GPa grade AHSS.

Preprint ARTICLE | doi:10.20944/preprints202311.0573.v1

Determination and Quantification of Acetaldehyde, Acetone and Methanol in Hand Sanitizes Using Headspace GC-MS: Effect of Storage Time and Temperature

Jacob Abraham Theruvathu, Chessa To

Subject: Chemistry And Materials Science, Other Keywords: Hand sanitizer; alcohol; acetaldehyde; acetone; GC/MS; isotope; storage time; temperature

Online: 9 November 2023 (07:25:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0609.v1

Pathogenic Variants in USH1G/SANS Alter the Protein Interaction With the Pre-RNA Processing Factors PRPF6 and PRPF31 of the Spliceosome

Jacques S. Fritze, Felizitas F. Stiehler, Uwe Wolfrum

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: splicing, U4/U6.U5 tri-snRNP, Usher syndrome, protein-protein interaction, FRET, AlphaFold2, in silico structure predictions,

Online: 9 November 2023 (07:25:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0591.v1

Use of Natural Deep Eutectic Solvents (NADES) for the Selective Fractionation of Bioactive Low Molecular Weight Carbohydrates

Ignacio Jiménez Amezcua, Manuel Ignacio López Martínez, A.I. Ruiz-Matute, María Luz Sanz

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Natural Deep Eutectic Solvents (NADES); ketoses; aldoses; fractionation; low molecular weight carbohydrates

Online: 9 November 2023 (07:24:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0593.v1

Primary Mosaic Neuroendocrine-/Adenocarcinoma of The Prostate: Clinical and Histological Description

Kálmán Almási, Noémi Kránitz, Tamás Kullmann

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: neuroendocrine; mosaic; prostate cancer; immunohistochemistry; tumour marker

Online: 9 November 2023 (07:24:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0574.v1

Feelings of Guilt as Experienced by Vegans – a Large-Scale Qualitative Study

Melanie Neumann*, Caroline Hesse, Mira Möhrmann, Anna-Lena Lumma, Friedrich Edelhäuser

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: vegan diet; guilt; feelings of guilt; ethical vegans; qualitative study; mental health; embodiment

Online: 9 November 2023 (07:24:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0608.v1

Antimicrobial Susceptibility Profile of Klebsiella pneumoniae Isolated as a Foodborne Pathogen From Some Dairy Products in Libya

Salah M. Azwai, Aml F. Lawila, Hanan L. Eshamah, Jihan A. Sherif, Samira A. Farag, Hesham T. Naas, Aboubaker M. Garbaj, Allaaeddin A. EL Salabi, Fatim T. Gammoudi, Ibrahim Eldaghayes

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Klebsiella pneumoniae; Dairy products; foodborne; Antibiotic sensitivity; Libya.

Online: 9 November 2023 (07:23:51 CET)

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Klebsiella pneumoniae is one of the most common causes of clinical and asymptomatic mastitis in dairy cattle, also in milk and dairy products affecting its quality. Mastitis caused by K. pneumoniae is even more serious due to its poor response to antibiotic therapy. This study was conducted to detect and identify the presence of K. pneumoniae in milk and dairy products. A total of 234 samples were randomly collected from various locations in Libya. Samples were examined for the presence of K. pneumoniae by conventional cultural techniques that included cultivation in violet red bile agar plus 4-methylumbelliferyl-ß-D-glucuronide (VRBA + MUG) broth, and CHROM agar followed by identification by PCR and partial sequencing of 16S rRNA. Out of the 234 samples of milk and dairy products collected, 16 (6.8%) of the isolates revealed mucoid colonies on agar media phenotypically suggested to be K. pneumoniae. The isolates identification was confirmed by molecular techniques (16S rRNA). Among examined samples, K. pneumoniae was recovered from she camel’s milk, raw cow’s milk, raw fermented milk, Maasora cheese, Ricotta cheese, soft cheese, full cream milk powder, milk powder infant formula, cereal baby food and growing up formula. From the 16 K. pneumoniae isolates; antibiotic susceptibility testing was performed on 12 isolates, the results showed that K. pneumoniae isolates were resistant to more than 8 antibiotics, interestingly, two isolates revealed MBL production. This study emphasized the relationship between K. pneumoniae and raw milk, cheese, milk powder and infant milk retailed in Libya, which is considered as a risk for human health as many of these products did not comply with microbiological criteria of international and/or Libyan standards. The necessary precautions have to be taken to carry out effective sanitary practices during the production in dairy plants, handling and distribution in the markets particularly at local small manufacture scale.

Preprint ARTICLE | doi:10.20944/preprints202311.0575.v1

Index of Rezidential Development: Evaluation of the Possibility of New Residential Construction Depending on the City Plan

Petr Vařbuchta, Vít Hromádka

Subject: Engineering, Civil Engineering Keywords: Index of Development; Index of Residential Development; Urban Planning; Spatial Planning; City Plan; Residential Housing

Online: 9 November 2023 (07:23:19 CET)

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This article focuses on the issue of urban development of cities and their residential development from the perspective of spatial planning. Spatial planning fundamentally determines, what kind of construction is feasible in cities. However, spatial plans often do not consider spatial limits, which often go against the proposed ways of using of the given sites, or make their use fundamentally difficult, for example by disproportionately increasing of the costs of residential construction, when it is necessary to remediate old burdens in the defined locality. The subject of the presented research was to examine the possibility of establishing an Index of Residential Development (IoRD), which evaluates the possibilities of residential development in the territory of urban agglomerations. The aim of the research, in the form of establishing of an Index of Residential Development (IoRD), was to assess, how it is possible to consider spatial limits associated with residential construction in urban intravilanes in order to identify the objectives of further spatial development planned by cities. Subsequently, the partial aim of the research was also to create a usable tool for support in the decision making of development organizations on the location of their project in a given space. Based on the results of the research, it was deduced that the limits associated with the residential development in intravilanes based on the IoRD could be considered. Clear links were also shown between the limits in the territory and the impaired possibility of construction in cities with zoning plans, which did not respond to the limits in the territory by adding other design zones, or completely ignored them. Although the methodology for determining of the Index of Residential Development (IoRD) was verified due to the availability of data in the case study carried out in the Czech Republic – the city of Brno, the methodology is applicable to any urban agglomeration even outside the Czech Republic when fulfilling the conditions defined in the article.

Preprint ARTICLE | doi:10.20944/preprints202311.0606.v1

A Common Polymorphism in RNASE6 Impacts Its Antimicrobial Activity Toward Uropathogenic Escherichia coli

Raul Anguita, Guillem Prats-Ejarque, Mohammed Moussaoui, Brian Becknell, Ester Boix

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: RNase; RNase 6; RNase k6; single nucleotide polymorphisms; antimicrobial peptides; urinary tract infections; uropathogenic Escherichia coli

Online: 9 November 2023 (07:22:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0597.v1

The Genome Assembly and Annotation of the Chinese Cobra, Naja atra

Jiangang Wang, Yuxin Wu, Shiqing Wang, Weiwu Mu, Wenmei Zeng, Xi Chen, Kangfeng Jiang, Liangyu Yang, Guohai Hu, Fengping He

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Genetics and Genomics, Zoology, Animal Genetics

Online: 9 November 2023 (07:21:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0607.v1

Complex Rayleigh-Van Der Pol-Duffing Oscillators: Dynamics, Phase and Anti-Phase Synchronization

Gamal M. . Mahmoud, Ahmed A. Farghaly, Tarek M. Abed-Elhameed, Asma Al Themairi

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: hyperchaotic; complex; Rayleigh-Van der Pol-duffing oscillator; phase synchronization; anti phase synchronization

Online: 9 November 2023 (07:21:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0599.v1

Mechanics of A Thin-Walled Torus Snap Fit

Xiao-Lin Guo, Bohua Sun

Subject: Engineering, Mechanical Engineering Keywords: torus; snap fit; elasticity; friction; Gauss curvature

Online: 9 November 2023 (07:20:34 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.0552.v1

A Review on Plant Fungal Disease Detection based on RGB, Multispectral and Thermal Camera

Ganga H. Yadahalli, Gouri H. Sukali, Aishwarya T S, Gyanappa A Walikar

Subject: Engineering, Electrical And Electronic Engineering Keywords: fuzzy logic; convolution neural network; surf features; support vector machines; FTIR spectrum; maximum temperature difference (MTD)

Online: 9 November 2023 (07:20:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0545.v1

Physical and Mechanical Properties and Damage Mechanism of Sandstone at High-Temperature

Yadong Zheng, Lianying Zhang, Peng Wu, Xiaoqian Guo, Ming Li, Fuqiang Zhu

Subject: Environmental And Earth Sciences, Other Keywords: sandstone; high-temperature; heating rate; physical and mechanical properties; acoustic emission; macroscopic de-structive characteristic; microscopic morphology

Online: 9 November 2023 (07:19:03 CET)

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The physical and mechanical properties of rocks will change significantly after being subjected to high temperatures, which poses safety hazards to underground projects such as coal underground gasification. In order to investigate the effect of temperature on the macroscopic and microscopic properties of rocks, this paper has taken sandstone as the research object and conducted uniaxial compression tests on sandstone specimens at different temperatures (20-1000 ℃) and different heating rates (5-30 ℃/min) at 1200 ℃. At the same time, the acoustic emission (AE) test system was used to observe the acoustic emission characteristics of the rock damage process, and the microstructural changes after high temperature were analyzed with the help of a scanning electron microscope (SEM). The test results show that the effect of temperature on sandstone is mainly divided into three stages: Ⅰ (20-500 ℃) stage is the strengthening zone, the evaporation of water and the contraction of primary fissures, sandstone densification is enhanced. Specifically, the compressive strength and elastic modulus increase, the macroscopic damage mode is dominated by shear damage, and the fracture micro-morphology is mainly brittle fracture. Stage II (500-600°C) is the transition zone, 500°C is the threshold temperature for compressive strength and modulus of elasticity, and the damage mode changes from shear to cleavage damage, and the sandstone undergoes brittle-ductile transition in this temperature interval. Stage III is the physicochemical deterioration stage. The changes in physical and chemical properties make the sandstone compressive strength and modulus of elasticity continue to decline, the macroscopic damage mode is mainly dominated by cleavage damage, and the fracture microscopic morphology is more toughness fracture. The effect of different heating rates on the mechanical properties of sandstone was further studied, and it was found that the mechanical properties of the rock were more deteriorated under higher heating rates.

Preprint REVIEW | doi:10.20944/preprints202311.0604.v1

The Usefulness of Magnetic Resonance Imaging(MRI) for Detection of Appendicitis – a Diagnostic Test Accuracy Meta-Analysis

Manav Patel, Dev Andharia, Abhijay Shah, Hetvi Shah, Dev Patel, Dev Desai

Subject: Medicine And Pharmacology, Surgery Keywords: MRI; US; CT; Appendicitis

Online: 9 November 2023 (07:18:42 CET)

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Background: Appendicitis is a common cause of emergency department visits and appendectomies in the US, with 250,000 appendectomies performed annually. Current diagnostic methods, such as clinical findings, lead to inaccuracies and missed diagnoses, increasing morbidity and mortality. The only solution is surgery, but current hematological tests are not reliable and may lead to unnecessary surgery if the underlying etiology is self-limiting or requires medical treatment. This study explores the role of MRI as a diagnostic modality that can replace US/CT and supplement traditional clinical diagnostic signs while avoiding ionizing radiation and intravenous contrast medium. The purpose of this meta-analysis is to determine the accuracy of MRI as a diagnostic modality in diagnosing appendicitis, addressing concerns about diagnostic modalities and their adverse effects, and addressing the necessity and success of relevant interventions. Methods: Medical literature was comprehensively searched and reviewed without restrictions to particular study designs, or publication dates using PubMed, Cochrane Library, and Google Scholar databases for all relevant literature formulated in English. The extraction of necessary data proceeded after specific inclusion and exclusion criteria were applied. Meta Analysis was performed for 5206 patients, with 35 RCTs being selected. Analysis was done using the QualSyst tool, wherein two writers independently assessed the caliber of each study as well as the use of the Cochrane tool for bias risk apprehension. The statistical software packages RevMan (Review Manager, version 5.3), SPSS (Statistical Package for the Social Sciences, version 20), and Excel in Stata 14 were used to perform the statistical analyses along with other analytical software. Results: MRI had an overall sensitivity of over 95%, an overall specificity of 94.2% with a PPV of 0.875 in comparison to CT scan in the diagnosis and intervention regarding appendicitis. Conclusion: These findings strongly suggest that MRI is a reasonable alternative to CT for the diagnosis of appendicitis in hospitals with appropriate access to this technology for reasons about accuracy, reliability, and reproducibility as well as addressing safety concerns.

Preprint ARTICLE | doi:10.20944/preprints202311.0600.v1

A New Vehicle Specific Power Model for the Estimation of Hybrid Vehicle Emissions

Ante Kozina, Tino Vidović, Gojmir Radica, Ante Vučetić

Subject: Engineering, Transportation Science And Technology Keywords: Hybrid Electric Vehicles; Vehicles models; VSP analyses

Online: 9 November 2023 (07:17:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0551.v1

The csQCA Analysis on Success or Failure of Adding Elevators to Old Buildings in China under the Multiple Coordination

Luo Hongxia, Jin Guofu

Subject: Social Sciences, Urban Studies And Planning Keywords: Adding elevators to the old building in China; Multiple coordination; Crisp-Set Qualitative Comparative Analysis

Online: 9 November 2023 (07:16:50 CET)

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