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Preprint ARTICLE | doi:10.20944/preprints202312.0281.v1

Metabolite Biomarkers for Early Ischemic Hypoxic Encephalopathy: An Experimental Study Using the NeoBase 2 MSMS Kit in a Rat Model

Yulia Shevtsova, Natalia Starodubtseva, Alisa Tokareva, Kirill Goryunov, Alsu Sadekova, Irina Vedikhina, Tatiana Ivanetz, Oleg Ionov, Vladimir Frankevich, Egor Plotnikov, Gennady Sukhikh, Dmitry Zorov, Denis Silachev

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: metabolomics; amino acids; diagnostics; neonatal asphyxia; liquid chromatography–mass spectrometry; newborn screening

Online: 5 December 2023 (15:31:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.2213.v1

A Life-Cycle Carbon Emissions Model for Traditional Residential Houses: Applying to Traditional Dong Dwellings in Qandongnan, Guizhou Province, China

Sicheng Wang, Yuanyuan Guo, Hao Zhang, Mingming Gao

Subject: Arts And Humanities, Architecture Keywords: dong dwellings; comfortable residence; green building; building physical environment; life-cycle carbon emissions

Online: 30 June 2023 (10:33:06 CEST)

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In recent years, due to the low energy utilization of the whole life-cycle of buildings and the di-minished indoor and outdoor comfort of buildings and the impact on the surrounding environ-ment caused by the carbon emissions of the building life-cycle, the establishment of a whole life- cycle carbon emission model for buildings to improve their energy utilization at all stages of their life-cycle has received unprecedented attention. In China, the construction industry has become a major carbon emitter, and traditional houses, as a green development building type, are an effec-tive way to achieve carbon neutrality in buildings, but the existing green building evaluation system lacks quantitative indicators of carbon emissions in the building life-cycle. The exclusive evaluation indexes for regional and characteristic buildings, such as traditional houses, are ne-glected; This study explored the formula for calculating the life-cycle carbon emissions model of traditional residential houses under a carbon emission intervention and used real measurements of the physical environment and comparative analysis of the limitations of existing local stand-ards; The results showed that the carbon emission calculation formulas for each stage of the life-cycle of traditional residential houses must be established by combining the selection of local building materials, and the materials for sustainable energy and carbon sinks of green systems. Based on the results of indoor and outdoor heat and humidity environmental tests of residential houses and an analysis of the limitations of existing evaluation indexes due to locality, four im-portant factors affecting locality green buildings in terms of energy utilization, site ecology and landscape, land saving and material saving were extracted; on this basis, the whole life-cycle carbon emission model of traditional residential houses is constructed by combining the existing green building evaluation standards with the carbon emission indexes of the life-cycle of tradi-tional residential houses.

Preprint ARTICLE | doi:10.20944/preprints202305.0980.v1

Development of a Decision Model for Korean OTT Service Users to Adopt Wireless D2D Caching Networks on Their Mobile Devices

Yumi Jang, Seongcheol Kim

Subject: Engineering, Telecommunications Keywords: Mobile OTT service; wireless D2D caching networks; mobile communication technology; OTT content delivery; the analytic hierarchy process (AHP)

Online: 15 May 2023 (05:32:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0098.v1

One-Class Machine-Learning Model to Screen for Dysglycemia Using Single Lead ECG in ICU, toward Noninvasive Blood Glucose Monitoring

I-Min Chiu, Chi-Yung Cheng, Po-Kai Chang, Chao-Jui Li, Fu-Jen Cheng, Chun-Hung Richard Lin

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: machine learning; dysglycemia; blood glucose, ECG, personalized medicine, noninvasive blood glucose monitor

Online: 4 August 2022 (04:00:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0280.v1

TPE-RBF-SVM Model for Soybean Categories Recognition in Selected Hyperspectral Bands Based on Extreme Gradient Boosting Feature Importance Values

Qinghe Zhao, Zifang Zhang, Yuchen Huang, Junlong Fang

Subject: Engineering, Automotive Engineering Keywords: Hyperspectral Technology; Non-destructive Testing; Soybean; Machine Learning; Support Vector Machine; Extreme Gradient Boosting; Tree-structured Parzen Estimator

Online: 19 July 2022 (07:12:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0464.v1

Integrаtion the UTАUT2 Model: Аdoption of E-Commerce as Solution for Fаshion Industry in Bаndung Fаcing the COVID-19 Pаndemic

Astri Wulandari, Donni Junipriansa, Bethani Suryawardani, Dandy Marcelino

Subject: Business, Economics And Management, Business And Management Keywords: e-commerce adoption; UTAUT2; fashion industry; digital marketing; covid pandemic.

Online: 25 November 2021 (09:07:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0011.v1

The Analytical Solution of the Grouting Migration Height for the Post-Grouted Drilled Shaft Based on the Herschel-Bulkley Model

Gan Nan, Haiming Liu, Yanjie Zhang, Wenyun Ding, Jing Cao, Rongtao Yan

Subject: Engineering, Civil Engineering Keywords: Grouting migration height; Herschel-Bulkley model; Post-grouted drilled shafts; Layered soils; Iterative calculation method

Online: 1 September 2021 (12:08:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0217.v2

Decide Now or Wait for the Next Forecast? A Decision Framework Based on an Extension of the Cost-Loss Model

Stephen Jewson, Sebastian Scher, Gabriele Messori

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: cost-loss; forecast change; forecast volatility; decision making; expected utility; probabilistic forecasts; ensemble forecasts

Online: 8 May 2020 (04:28:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0101.v1

Ridge to Reef Management Implications for the Development of an Open-Source Dissolved Inorganic Nitrogen Loading Model in American Samoa

Christopher Shuler, Mia Comeros-Raynal

Subject: Environmental And Earth Sciences, Environmental Science Keywords: nutrient loading; geospatial model; dissolved inorganic nitrogen; water quality; island management

Online: 6 March 2020 (03:23:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0368.v1

Using Recurrent Procedures in Adaptive control System for Identify the Model Parameters of the Moving Vessel on the Cross Slipway

Hanna Rudakova, Oksana Polyvoda, Anton Omelchuk

Subject: Computer Science And Mathematics, Information Systems Keywords: slipway; adaptive control system; the method of least squares; procedure periodic; parameter estimation; large-sized object; a recurrent algorithm; the identification procedure

Online: 15 November 2018 (15:47:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0777.v1

Delineating Ecological Functional Zones and Grades for Multi-Scale Ecosystem Management

Yan Zhang, Shuhan Liu, Peiheng Yu, Yanchi Lu, Yang Zhang, Jinting Zhang, Yiyun Chen

Subject: Environmental And Earth Sciences, Ecology Keywords: ecosystem services; ecological functional zones; tradeoffs and synergies; self-organizing feature mapping; multi-scale management ;

Online: 10 September 2024 (09:42:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1618.v1

BESO and SESO: Comparative Analysis of Spatial Structures Considering Self-Weight and Structural Reliability

Hélio Luiz Simonetti, Valério S. Almeida, Francisco de Assis das Neves, Sina Zhian Azar, Márcio Maciel da Silva

Subject: Engineering, Civil Engineering Keywords: 3D-Topology Optimization; BESO; SESO; RBTO; Self-Weight

Online: 24 June 2024 (11:49:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.0778.v1

Enhancing Sustainable Analytical Chemistry in Liquid Chromatography: Guideline for Transferring Classical HPLC and UHPLC Methods into Greener, Bluer, and Whiter Methods

Sami El Deeb

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: green chemistry; green analytical chemistry; blue analytical chemistry; white analytical chemistry; sustainable analytical chemistry; sustainability; sustainable development; sustainability guideline; solvent selection; liquid chromatography

Online: 12 June 2024 (11:13:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0585.v1

Grover Disease Association with Cutaneous Keratinocyte Cancers: More than a Coincidence?

Roxana Nedelcu, Alexandra Dobre, Gabriela Turcu, Razvan Andrei, Elena Balasescu, Florentina Pantelimon, Mihaela David-Niculescu, Adina Dobritoiu, Raluca Radu, Georgiana Zaharia, Ionela Hulea, Alice Brinzea, Lorena Manea, Mihaela Gherghiceanu, Daniela Ion

Subject: Medicine And Pharmacology, Dermatology Keywords: cutaneous keratinocyte cancers; non-melanoma; basal cell carcinomas; cutaneous squamous cell carcinomas; Grover disease; transient acantholytic dermatosis

Online: 8 August 2024 (12:07:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0593.v1

Effectiveness of Atezolizumab in Metastatic Large Cell Neuroendocrine Carcinoma of the Lung and the Predictive Value of miR-375. The LANCE Trial, a Pilot Study

Georgios Evangelou, Ioannis P. Trontzas, Ioannis Gkiozos, Ioannis Vamvakaris, Maria Grammoustianou, Christina Paraskeva, Georgia Gomatou, Ioannis Tsamis, Ioannis A. Vathiotis, Maximilian Anagnostakis, Vasiliki Koliaraki, Konstantinos Syrigos

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: large cell neuroendocrine carcinoma; LCNEC; immunotherapy; atezolizumab; miR375

Online: 11 March 2024 (17:49:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1955.v1

Maternal COVID-19 serological Changes. Comparison between seroconversion Rate in First and Third Trimester of Pregnancy and Subsequent Obstetric Complications: A Cohort Study

Maria N Rayo, Adriana Aquise, Irene Fernandez-Buhigas, Lorena Gonzalez Gea, Coral Garcia Gonzalez, Mirian Sanchez Tudela, Miguel Rodriguez Fernandez, Diego Tuñon-Le Poultel, Belén Santacruz, María M. Gil

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: SARS-CoV-2; pregnancy; morbidity

Online: 30 October 2023 (16:13:03 CET)

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Preprint REVIEW | doi:10.20944/preprints202406.0449.v1

Interaction of Vasopressin with Hormones of the Hypothalamo-Pituitary-Adrenal Axis: Significance for Therapeutic Strategies in Cardiovascular and Metabolic Diseases

Ewa Krystyna Szczepańska-Sadowska, Katarzyna Czarzasta, Wiktor Bogacki-Rychlik, Michał Kowara

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: AVP; CRH; ACTH; glucocorticoids; mineralocorticoids; androgens; estrogens; hypertension; cardiac failure; stress

Online: 7 June 2024 (08:24:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0660.v1

Shared E-scooter Usage Analysis considering the Effect of Weather Conditions and Land Use: Qatar Case Study

Mohammed Elhenawy, Anas Mohammed, Shahram Tahmasseby, Salwa Salam, Wael Alhajyaseen, Ioannis Karakikes, Ioannis Tsouros, Athina Tsirimpa, Amalia Polydoropoulou

Subject: Engineering, Transportation Science And Technology Keywords: ﬁrst-/last-mile transport; shared e-scooters; urban mobility planning; policy development; weather impact

Online: 11 June 2024 (06:57:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1216.v1

Autism Spectrum Disorder and BRIEF‐P: A Review and Meta‐Analysis

Esperanza Bausela-Herreras

Subject: Social Sciences, Psychology Keywords: BRIEF-P; flexibility; Executive Functions; inhibition; Miyake model; working memory; Autism Spectrum Disorder

Online: 15 July 2024 (17:09:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1186.v1

Uav-Assisted Cooperative Noma and Ofdm Communication Systems: Analysis and Optimization

Xuan Thuc Kieu, Anh Le-Thi

Subject: Engineering, Telecommunications Keywords: UAV-NOMA; UAV-OFDM; Successive convex optimization SCO; Sum data rate; Block-coordinate gradient descent BCGD.

Online: 19 December 2023 (02:57:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1751.v1

Vibration and Aerodynamic Analysis and Optimization Design of a Test Centrifuge

Chun-yan Deng, Li-dong He, Zhi-fu Tan, Xing-yun Jia

Subject: Engineering, Control And Systems Engineering Keywords: Test centrifuge; Numerical simulation; Vibration analysis; Pneumatic analysis; Structural optimization design

Online: 26 June 2023 (05:41:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202301.0096.v1

Trend Research of Diabetes and Pyroptosis: Bibliometric Analysis and Literature Review

Li Xiaodong, Su Xiaojuan, Xu Mingchao

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Diabetes Mellitus; Diabetic Complications; Pyroptosis; Bibliometrics

Online: 5 January 2023 (03:37:02 CET)

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Objective: To visualize and analyze the published literature on diabetes and pyroptosis based on a bibliometric approach, so as to provide a comprehensive picture of the hot research directions and dynamic progress in this field. Methods: This study was based on the web of science core collection database to conduct a comprehensive search of the published literature in the field of diabetes and Pyroptosis from January 1985 to August 2022, including the published research literature in this field, as well as a visual analysis of the number of citations, year of publication, journal, author, research institution, country, and research topic. Results: A total of 139 literature on research related to diabetes and cellular scorch from 2011 to 2022 were retrieved, with a total of 3009 citations and a maximum of 255 citations for a single article, which had a first authorSchmid-Burgk, JL The first author of this article is from Germany; among 20 publishing countries, China leads with 100 articles; among 222 publishing institutions, Harbin Medical University leads with 18 articles and 184 citations; among 980 authors, Chen, X from China tops the list of high-impact authors with 5 articles and 29 citations; Among the 98 journals, "CELL DEATH DISEASE" ranked first in both volume and high impact journals with 4 articles and 29 citations; among 349 keywords, "pyroptosis" ranked first with a cumulative frequency of 65 times. The cluster analysis was divided into three categories, chronic complications of diabetes and pyroptosis (67 articles), diabetes and pyroptosis (60 articles), and diabetes combined with other diseases and pyroptosis (12 articles), and the number of articles related to diabetes and its chronic complications increased rapidly from 2019, among which, diabetic cardiomyopathy (27 articles) had the highest number of articles. Conclusions: Based on a comprehensive analysis of published literature in the field of diabetes and pyroptosis from 2011-2022, this study achieved a visual analysis of studies with significant and outstanding contributions to the field, thus framing a picture showing the development and changes in the field. At the same time, this study provides research information and direction for clinicians and investigators to conduct diabetes and pyroptosis related research in the future.

Preprint ARTICLE | doi:10.20944/preprints201810.0748.v1

Social Capital, Human Capital, and Sustainability: A Bibliometric and Visualization analysis

M. Dolores Botella-Carrubí, Fernando J. Garrigos-Simon, Tomás Gonzalez-Cruz

Subject: Business, Economics And Management, Business And Management Keywords: social capital; human capital; bibliometric; visualization

Online: 31 October 2018 (10:22:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints201803.0155.v1

Buckwheat and CVD Risk Markers, a Systematic Review and Meta-Analysis

Liangkui Li, Georg Lietz, Chris J. Seal

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: buckwheat; CVD risk markers; meta-analysis

Online: 19 March 2018 (10:45:19 CET)

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Preprint REVIEW | doi:10.20944/preprints202406.1821.v1

Dynamic and Energetic Aspects of Carotenoids In-and-Around Model Lipid Membranes Revealed in Molecular Modelling

Marta Pasenkiewicz-Gierula, Jakub Hryc, Michal Markiewicz

Subject: Biology And Life Sciences, Biophysics Keywords: spontaneous membrane intercalation; preferred membrane orientation; free energy gain; timescales; lipid-soluble antioxidant; trans-cis photoisomerisation

Online: 26 June 2024 (08:51:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0236.v1

The Relaxation Model of Relation between Elastic Modulus and Thermal Expansivity of Thermosetting Polymers’ and Frps’

Alexander Korolev, Maxim Mishnev, Dmitriy Ulrikh, Alexander Zadorin

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: polymers; polymer composites; glass fiber reinforced plastics; elasticity; modulus of elasticity; thermal expansivity; coefficient of thermal expansion; relaxation; thermo-relaxation

Online: 13 January 2023 (06:26:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints201808.0535.v1

Establishing Laboratory Cultures and Performing Ecological and Evolutionary Experiments with the Emerging Model Species Chironomus Riparius

Quentin Foucault, Andreas Wieser, Ann-Marie Waldvogel, Markus Pfenninger

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Chironomus riparius, laboratory cultures, experimental evolution

Online: 30 August 2018 (15:57:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0177.v1

Fluoxetine and Sertraline Potently Neutralize the Replication of Distinct SARS-CoV-2 Variants

Laura Thümmler, Nadine Beckmann, Caroline Sehl, Matthias Soddemann, Peer Braß, Maren Bormann, Leonie Brochhagen, Carina Elsner, Nicolas Hoertel, Céline Cougoule, Sandra Ciesek, Marek Widera, Ulf Dittmer, Monika Lindemann, Peter A. Horn, Oliver Witzke, Stephanie Kadow, Markus Kamler, Erich Gulbins, Katrin Anne Becker, Adalbert Krawczyk

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; antidepressants, COVID-19

Online: 4 March 2024 (19:12:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.0689.v1

Chemical Differentiation and Quantitative Analysis of Black Ginseng Based on a LC-MS Combined with Multivariate Statistical Analysis Approach

Lele Li, Zhixia Chang, Keyu Wei, Yi Tang, Zhao Chen, Hongli Zhang, Yang Wang, Bo Feng, Heyun Zhu

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Black ginseng; Ginsenosides; UPLC-Q-TOF/MS; processing; multivariate statistical analysis

Online: 9 June 2023 (08:43:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0185.v1

Analysis of Omega-3 (ω-3) Fatty Acid in Indonesia Fish Oils Using Infrared Spectroscopy and Multivariate Data Analysis

Irnawati Irnawati, Anjar Windarsih, Nurrulhidayah A. Fadzilah, Florentinus Dika Octa Riswanto, Abdul Rohman

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: EPA-DHA; marine oils; FTIR spectra; chemometrics; partial least square

Online: 4 May 2023 (04:17:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0193.v1

Spatiotemporal Characterization of Chromophoric Dissolved Organic Matter (CDOM) and CDOM-DOC Relationships for Highly-Polluted River

Sijia Li, Jiquan Zhang, Guangyi Mu, Hanyu Ju, Rui Wang, Danjun Li

Subject: Environmental And Earth Sciences, Environmental Science Keywords: chromophoric dissolved organic matter; polluted waters; optical properties; Yinma River watershed

Online: 23 August 2016 (10:35:36 CEST)

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Spectral characteristics of CDOM in water column are a key parameter for bio-optical modeling. Knowledge of CDOM optical properties and spatial discrepancy based on the relationship between water quality and spectral parameters in Yinma River watershed with in situ data collected highly-polluted waters are exhibited in this study. Seasonal field data sets collected over a period of 2 months in 2015 in Yinma River Watershed. Based on the comprehensive index method, the riverine waters showed serious contamination, especially the COD, Fe, Mn, Hg and DO were out of range contamination warning. Dissolved organic carbon (DOC) and total suspended matter (TSM) with prominent non-homogenizing were significantly high in the riverine waters, but chlorophyll-a (Chl-a) was opposite. Ternary phase diagram showed that non-algal paritcles absorption played an important role in total non-water light absorption (>50%) in most sampling locations, and mean contribution of CDOM were 13% and 22% in summer and autumn respectively. Analysis of ratio of absorption at 250-365 nm (E_250:365) and spectral slope (S_275-295) indicated that CDOM had higher aromaticity and molecular weight in autumn than in summer, is consistent with the results of water quality and relative contribution. Redundancy analysis (RDA) indicated that the environmental variables OSM had a strong correlation with CDOM absorption, followed by heavy metal, e.g., Mn, Hg and Cr⁶⁺. However, for the specific UV absorbance (SUVA₂₅₄), the seasonal values showed opposite results compared with the reported literature. The potential reasons were the more UDOM (uncolored Dissolved Organic Matter) from human source (wastewater effluent) existed in waters. Terrigenous inputs simultaneously are in relation to the a_CDOM(440)-DOC relationship with the correlation coefficient was 0.90 in summer (2-tailed, p<0.01), and 0.58 in autumn (2-tailed, p<0.05). Spatial distribution of CDOM parameters exhibited that the downstream regions focused on dry land have high CDOM molecular weight and aromatic hydrocarbon. Partial sampling locations around the cities or countries generally showed abnormal values due to terrigenous inputs. As a bio-optical model parameter, spectral characteristic of CDOM is helpful in adjusting the derived algorithms in highly-polluted environments. The study on organic carbon and pollutants in highly-polluted waters had an important contribution to global carbon balance estimation and water environment protection.

Preprint REVIEW | doi:10.20944/preprints202404.0913.v1

Statins for Heart Failure with Preserved Ejection Fraction: Current Evidence and Perspectives

Artem Ovchinnikov, Alexandra Potekhina, Tatiana Arefieva, Anastasiia Filatova, Fail Ageev, and Evgeny Belyavskiy

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: statins; heart failure with preserved ejection fraction; inflammation; diastolic dysfunction; prognosis

Online: 15 April 2024 (07:25:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0557.v1

Comparison between Ultrasonographic-Guided Temporal and Coronoid Approaches for Trigeminal Nerve Block in Dogs: A Cadaveric Study

Álvaro Jesús Gutiérrez Bautista, Manon Mikic, Pablo Otero, Virginia Rega, Francisco Medina-Bautista, José Ignacio Redondo García, Sabine Kästner, Adriano Wang-Leandro

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: mandibular; maxillary; and ophthalmic nerves; regional anaesthesia; canine; orbitotomy; analgesia; computed tomography

Online: 9 May 2024 (09:16:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0995.v1

Rationale and Protocol of ETERNITY-ITA Study: Use of Etelcalcetide for Preserving Vitamin K-Dependent Protein Activity Italian Study

Maria Fusaro, Andrea Aghi, Carmela Marino, Francesca Mallamaci, Mario Plebani, Martina Zaninotto, Maria Grano, Silvia Concetta Colucci, Maurizio Gallieni, Thomas L. Nickolas, Sandro Giannini, Stefania Sella, Paolo Simioni, Alberto Bazzocchi, Giuseppe Guglielmi, Fulvia Taddei, Enrico Schileo, Maria Carmela Versace, Giovanni Luigi Tripepi

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Bone fractures; Etecalcetide; Hemodialysis; Vascular calcification; Vitamin K.

Online: 14 August 2024 (07:14:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0104.v1

Nitrous Oxide Emission from Organic Fertilizer and Controlled Release Fertilizer in Tea Fields

Meihua Deng, Mudan Hou, Naoko Ohkama-Ohtsu, Tadashi Yokoyama, Haruo Tanaka, Yasuhiro Nakajima, Ryosuke Omata, Sonoko Dorothea Bellingrath-Kimura

Subject: Environmental And Earth Sciences, Environmental Science Keywords: controlled releasefertilizer (CRF); organic fertilizer; nitrous oxide; row; canopy

Online: 15 March 2017 (09:01:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.1831.v1

Mineralogical and Textural Analysis of Natural Hercynite-Spinel Compounds

Andrés I. González-Jacquez, Jose G. Murillo-Ramírez, Cesar Modesto-Acosta, Guillermo Herrera-Perez, Karla Campos-Venegas, César Leyva-Porras

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: Hercynite; Natural spinel; FeAl2O4; Neumann bands; Widmanstätten pattern

Online: 23 July 2024 (16:01:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1526.v1

Preliminary Analysis of Protein Catalytic Ability and Catalytic Structure

Zheming Cao

Subject: Physical Sciences, Biophysics Keywords: protein; high-energy state; catalysis; AlphaFold

Online: 18 July 2024 (16:45:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1191.v1

Coffee Flavoured Kombucha: Development, Physicochemical Characterization and Sensory Analysis

Morena Senna Saito, Wilton Amaral dos Santos, Maria Eugênia de Oliveira Mamede

Subject: Biology And Life Sciences, Food Science And Technology Keywords: process; innovation; arabica coffee; camellia sinensis; acceptability

Online: 17 May 2024 (15:56:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1104.v1

Analysis of AGVs Routes Considering Disturbances and Unexpected Events

Fernanda Coutinho, Edson Costa, Jorge Barreiros

Subject: Engineering, Control And Systems Engineering Keywords: mobile robots; AGV; route planning

Online: 14 December 2023 (14:14:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0385.v1

Micro- and Nano-Roughness Separation Based on Fractal Analysis

Árpád Czifra, Erzsébet Ancza

Subject: Engineering, Mechanical Engineering Keywords: roughness; fractal; bifractal; full length scale; microtopograpy; nanoroughness; power spectral density

Online: 7 November 2023 (10:38:56 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.1570.v1

Review and Analysis of Energy-Efficient AC Voltage Regulators

Aleksey Vjacheslavovich Udovichenko, Evgeniy Valer'evich Grishanov, Evgeniy Andreevich Kosykh, Ali Dzhavanshirovich Mekhtiyev

Subject: Engineering, Electrical And Electronic Engineering Keywords: AC voltage regulator; stabilizer; soft start of the motor; AC switch; transformer; energy efficiency

Online: 24 October 2023 (19:16:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1591.v1

Vulnerability Analysis Method Based on Network and Copula Entropy

Mengyuan Chen, Jilan Liu, Ning Zhang, Yichao Zheng

Subject: Business, Economics And Management, Finance Keywords: graph theory and network analysis; Copula entropy; market vulnerability

Online: 22 August 2023 (14:54:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.2269.v1

A Longitudinal Analysis of Cyber Adversarial Tactics and Techniques

Marshall S. Rich

Subject: Computer Science And Mathematics, Information Systems Keywords: Behavioral Analysis; Behavioral Score; Cybersecurity; Data Analytics; Geographic Analysis; Longitudinal Study; Model Recalibration; Network Anomaly Detection; Organizational Analysis; Threat Intelligence

Online: 30 June 2023 (16:16:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1759.v1

Computation of Vascular Parameters: Implementing Methodology and Performance Analysis

Mohamed Yacin Sikkandar, Sridharan Padmanabhan, Bobby Mohan, Ibrahim AlMohimeed, Ahmad Alassaf, Shady A Alshewaier, Ali Abdullah Almukil, Sabarunisha Begum S

Subject: Engineering, Bioengineering Keywords: arterial compliance; stiffness index; pulse wave velocity; blood pressure; acoustic waves

Online: 26 May 2023 (10:46:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1399.v1

Phylogeny Analysis and Functional Characterizatiion of CYP76AHs from Salvia

Zhenyu Zhao, Dongfeng Yang, Juan Guo, Xiuyu Liu, Qishuang Li, Ping Su, Jian Wang, Ying Ma, Luqi Huang

Subject: Biology And Life Sciences, Other Keywords: Salvia; CYP76AH; P450; biosynthesis; functional gene

Online: 19 May 2023 (07:52:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0529.v1

Dynamic Modeling and Analysis of a Driving Passenger Vehicle

Seen Yun, Jeonga Lee, Woojae Jang, Daeji Kim, Minseok Choi, Jintai Chung

Subject: Engineering, Mechanical Engineering Keywords: dynamic analysis; dynamic model; dynamic responses; mode shapes; natural frequencies; suspension deformations; vehicle driving test; steering conditions

Online: 19 April 2023 (03:29:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0388.v1

Geostatistical Modeling and Heterogeneity Analysis of Tumor Molecular Landscape

Morteza Hajihosseini, Payam Amini, Dan Voicu, Irina Dinu, Saumyadipta Pyne

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: spatial single-cell analysis; intratumor heterogeneity; kriging; spatial entropy; Was-serstein distance; cancer; RNA-seq

Online: 26 September 2022 (08:57:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0094.v1

Design Simulation and Data Analysis of an Optical Spectrometer

Muddasir Naeem, Tayyab Imran, Mukhtar Hussain, Arshad Saleem Bhatti

Subject: Physical Sciences, Optics And Photonics Keywords: Spectrometer; NI LabVIEW; Virtual Image (VI); Diffraction Grating; ZEMAX

Online: 6 July 2022 (09:00:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0072.v3

Kabirian-based Optinalysis: Its Paradigm, Theorems, and Properties

Kabir Bindawa Abdullahi

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: isoreflectivity; autoreflectivity; Kabirian bi-coefficients; Kabirian-probability translation models; properties; computing codes

Online: 26 October 2022 (09:39:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0494.v1

Deformation and Stress Analysis of Catenary Shell of Revolution

Bohua Sun

Subject: Physical Sciences, Acoustics Keywords: Catenary; surface of revolution; Gauss curvature; minimal surface; shells; deformation; stress; Maple

Online: 19 April 2021 (14:03:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0530.v1

Anatomical and Image Analysis of Grain Coloration in Rye

Pavel A. Zykin, Elena A. Andreeva, Natalia V. Tsvetkova, Anatoly V. Voylokov

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: rye; image analysis; grain color; anthocyanins; proanthocyanidins

Online: 20 November 2020 (09:34:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0219.v1

Energy Analysis and Exergy Optimization of Photovoltaic-Thermal Collector

Sonja Kallio, Monica Siroux

Subject: Engineering, Energy And Fuel Technology Keywords: solar energy; micro-cogeneration; exergy; multi-objective optimization; PVT collector; PV panel

Online: 10 September 2020 (04:42:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0556.v1

An Analysis of Calorie Consumption and Elasticity in Vietnam

LINH HOANG VU

Subject: Business, Economics And Management, Economics Keywords: Food; calorie; Vietnam; elasticity

Online: 25 August 2020 (13:42:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0353.v1

Analysis and Forecast of COVID-19 Pandemic in Pakistan

Abdul Bari Malik

Subject: Computer Science And Mathematics, Analysis Keywords: COVID-19; Epidemiology; COVID-19 Analysis and Forecast in Pakistan; Forecasting; Estimation; ARIMA; Prophet; SIRD; Diffusion; Analysis

Online: 29 June 2020 (10:50:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0295.v1

Learning Dispositif and Emotional Attachment: A Preliminary International Analysis

Simon Huston, Elena Huston, Marek Kozlowski

Subject: Social Sciences, Education Keywords: learning dispositif; emotional attachment; learning journey; inclusion; scaffolding; student engagement

Online: 24 November 2019 (16:23:55 CET)

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This research investigated the significance of learning dispositif (LD) and emotional attachment (EA) on perceived learning success (LS) across a diaspora of Western, Russian, Asian, Middle Eastern and Chinese student cohorts. Foucault’s LD captures the disparate socio-cultural contexts, institutional milieus and more or less didactic teaching styles that moderate learning. EA is a multi-dimensional notion involving affective bonds that emerged in child psychology and spread to marketing and other fields. The sequential explanatory research reviewed the learning and EA literatures and generated an LD–EA framework to structure the quantitative phase of its mixed investigations. In 2017 and 2018, the research collected 150 responses and used a range of statistical techniques for quantitative analysis. It found that LS varied significantly across cohorts, intimating that dispositifs influence learning. Nonparametric analysis suggested that EA also influenced learning, but regressions were inconclusive. Exploratory techniques hint at a dynamic mix of emotional or cognitive motivations during the student learning journey, involving structural breaks in student/instructor relationships. Cluster analysis identified distinct student groupings, linked to years of learning. Separately, qualitative analysis of open-ended survey questions and expert interviews intimates that frequent teacher interactions can increase EA. The synthesis of quantitative with qualitative results and pedagogical reflection suggests that LD and EA both influence learning in a complex, dynamic system. The key constituents for EA are Affection, Connection, Social Presence (SP), Teaching Presence (TP) and Flow but student emotional engagement is conditioned by the socio-cultural milieu (LD) and associated factors like relationships and trust. Unlike in the Community of Learning framework, in the EA framework Cognitive Presence (CP) is an outcome of the interaction between these EA constituents, associated factors and the socio-cultural milieu. Finally, whilst awareness of culture and emotions is a useful pedagogical consideration, learning mainstays remain inclusive educational systems that identify student needs and support well-designed programmes. Within these, scaffolded modules should include a variety of engaging learning activities with non-threatening formative and trustworthy summative feedback. We acknowledge some statistical study limitations, but its tentative findings make a useful preliminary contribution

Preprint ARTICLE | doi:10.20944/preprints201808.0160.v1

Boundary Bound Diffraction: A Combined Spectral and Bohmian Analysis

Jalal Tounli, Aitor Alvarado, Ángel S. Sanz

Subject: Physical Sciences, Quantum Science And Technology Keywords: diffraction; Moshinsky shutter; spectral analysis; Bohmian mechanics; interference; quantum carpet; matter-wave optics

Online: 8 August 2018 (06:03:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0522.v1

In Silico Phylogenetic and Structural Analysis of Plant Damps

Athanasia pavlopoulou, Ezgi Karaca, Alma Balestrazzi, Alexandros Georgakilas

Subject: Biology And Life Sciences, Plant Sciences Keywords: DAMPs; alarmins; innate immune response; plants; phylogeny; in silico

Online: 26 July 2018 (16:08:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.1495.v1

Nanostructured Solid/Liquid Acid Catalysts for Glycerol Esterification: The Key to Convert Liability into Assets

John Keogh, Patcharaporn Inrirai, Nancy Artioli, Haresh Manyar

Subject: Chemistry And Materials Science, Chemical Engineering Keywords: Glycerol; Biodiesel; Biofuels; Fuel additives; Net Zero; Esterification, Solid acid catalysts

Online: 25 March 2024 (16:39:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0460.v1

Attrition Risk and Aircraft Suitability Prediction in U.S. Navy Pilot Training Using Machine Learning

Jubilee Prasad Rao, Olivia J Pinon Fisher, Jesse R Williams, Neil C Rowe, Tejas G Puranik, Dimitri N Mavris, Michael W Natali, Mitchell J Tindall, Beth W Atkinson

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Pilot Training; Machine Learning; Attrition Prediction; Aircraft Suitability; Cost Savings; Automation

Online: 27 February 2023 (08:42:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0421.v3

Drawbacks of Immune Checkpoint Inhibition and Rigorous Management for Immune Related Adverse Events Along with a Mathematical Model to Assess Therapy Success and Optimum Therapy Duration and a Strategy Against Tumor Plasticity

C. Mehmet Hendekli

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Oncology; Immune Checkpoint Inhibition; PD-1; PD-L1; CTLA-4; Immune Related Adverse Events; Immunotherapy; Tumor Plasticity; Tumor Microenvironment; Optimum Therapy Duration

Online: 6 March 2023 (01:53:16 CET)

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Preprint REVIEW | doi:10.20944/preprints202407.2126.v1

Molecular Targets for the Diagnosis and Treatment of Pancreatic Cancer

Robert George Pergolizzi, Steven Brower

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: PC (pancreatic cancer]); driver mutations; miRNA

Online: 26 July 2024 (12:58:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0171.v1

Non-Parametric Analysis of Nitrogen Trends in the form of Nitrate and Nitrite in Rivers and Streams of the Contiguous United States for 1990-2019

Amin Mohebbi, Simin Akbariyeh

Subject: Engineering, Civil Engineering Keywords: Nitrate-Nitrogen; Nitrite-Nitrogen; Non-Parametric Hypothesis Testing, Type II Error, Rivers and Streams

Online: 7 June 2021 (12:40:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0275.v1

Remote Sensing and GIS Application for Land use/ Land cover Change Analysis: Case Study of Jarmet Wet-Land and its Surrounding Environments in Western Ethiopia

Amanuel Kumsa, Professor Sileshi Nemomissa, Asmamaw (PhD) Legas, Dessalegn Gurmessa

Subject: Environmental And Earth Sciences, Ecology Keywords: Accuracy Assessment, Analysis Change, Detection analysis, Environmental change, GIS and Remote Sensing, Jarmet and others wetland change,LULC, change population growth

Online: 24 July 2019 (12:04:29 CEST)

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Wetlands are one of the crucial natural resources. They provide invaluable biodiversity resources, aid in water quality improvement, support ground water recharge, help in moderating climate change and support flood control. Environment is in the other hand, where we live and something, we are very familiar with our day to day life. Geographic Information Systems (GIS), Remote Sensing and Global Positioning System (GPS) were a useful tool for wetland and environmental change analysis and to improve on the classification accuracy. This study investigates population and environmental change of Jarmet wetland and its surrounding area change analysis over the period of 1972 to 2015. The purpose of this study was to show land use/ land cover change of Jarmet wetland and its surrounding environment over years as a response to population growth. For this purpose, multi-temporal satellite imageries (Landsat MSS 1972, TM1986, ETM+ 2000, 2005 and 2015 and SRTM 2000) were obtained and used for LULC change analysis, elevation analysis and change detection analysis. ERDAS Imagine 2015, ARC GIS 10.5.1, Global Mapper11, ENVI 5.0 and DNR Garmin softwares were used to process the image data and accuracy assessment analysis. The result of LULC showed that there is spatial reduction in wetland, forest, Shrubland and grassland in the period of 43 years (1972-2015) by -1,722.8 ha, -296.2 ha, -1,718.7 ha and -661.9 ha respectively, due to increase in the farmland and plantation area as a response to overpopulation, lack of environmental policy implementation and irresponsible for natural resource degradation. The accuracy assessment of LULC change are done for recent satellite image showed the overall accuracy of 84.06% with Kappa index 75.19% this means this classification is accurately classified and handle greater than 75% of error. Finally, this study suggests that create strictly natural resource conservation law, stopping illegal expansion of farmland, educating society about the value of natural resource especially wetland and create a source of income for society rather than farming.

Preprint ARTICLE | doi:10.20944/preprints202408.1465.v1

Evaluating the User Experience and Usability of the MINI Robot for Elderly Adults with Mild Dementia and Mild Cognitive Impairment: Insights and Recommendations

Aysan Mahmoudi Asl, José Miguel Toribio-Guzmán, Álvaro Castro-González, María Malfaz, Miguel Ángel Salichs, Henriëtte Van der Roest, Manuel Franco-Martín

Subject: Social Sciences, Psychiatry And Mental Health Keywords: usability; user experience; social robots; dementia; mild cognitive impairments

Online: 20 August 2024 (12:24:51 CEST)

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Background: In recent years, the integration of robotic systems into various aspects of daily life has become increasingly common. As these technologies continue to advance, ensuring user-friendly interfaces and seamless interactions becomes more essential. For social robots to genuinely provide lasting value to humans, a favourable user experience (UX) emerges as an essential prerequisite. Aim: This article aimed to evaluate the usability of the MINI robot, highlighting its strengths and areas for improvement based on user feedback and performance. Method: In a controlled lab setting, a mixed-method qualitative study was conducted with ten individuals aged 65 and above diagnosed with mild dementia (MD) and mild cognitive impairment (MCI). Participants engaged in individual MINI robot interaction sessions, completing cognitive tasks as per written instructions. Video and audio recordings documented interactions, while post-session System Usability Scale (SUS) questionnaires quantified usability perception. Ethical guidelines were followed, ensuring informed consent, and the data underwent qualitative and quantitative analyses, contributing insights into the MINI robot's usability for this demographic. Results: The study addresses the ongoing challenges that tasks present, especially for MD individuals, emphasizing the importance of user support. Most tasks require both verbal and physical interactions, indicating that MD individuals face challenges when switching response methods within subtasks. These complexities originate from the selection and use of response methods, including difficulties with voice recognition, tablet touch, and tactile sensors. These challenges persist across tasks, with individuals with MD struggling to comprehend task instructions and provide correct answers and individuals with MCI struggling to use response devices, often due to the limitations of the robot's speech recognition. Technical shortcomings have been identified. The results of the System Usability Scale (SUS) indicate positive perceptions, although there are lower ratings for instructor assistance and pre-use learning. The average SUS score of 68.3 places device usability in the "good" category. Conclusion: Our study examines the usability of the MINI robot, revealing strengths in quick learning, simple system and operation, and integration of features while also highlighting areas for improvement. Careful design and modifications are essential for meaningful engagement with people with dementia. The robot could better benefit people with MD and MCI if clear, detailed instructions and instructor assistance are available.

Preprint REVIEW | doi:10.20944/preprints202409.0576.v1

Securing Tomorrow’s Digital World: Key Trends in Cyber security for 2024

Md. Badiuzzaman Biplob, Suiching mong Marma, Mili Akther

Subject: Computer Science And Mathematics, Computer Science Keywords: threat detection; cybersecurity frameworks; behavioral biometrics; risk mitigation; cyber resilience; artificial intelligence; machine learning

Online: 9 September 2024 (11:39:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0388.v1

Biomechanically Tunable Nano-Silica/P-HEMA Structural Hydrogels for Bone Scaffolding

Raffaella Aversa, Relly Victoria Petrescu, Florian Ion T. Petrescu, Davide Apicella, and Antonio Apicella

Subject: Chemistry And Materials Science, Biomaterials Keywords: Biomimetic hydrogels; hybrid nanocomposites; anomalous sorption; Tissue engineering

Online: 15 March 2021 (13:44:37 CET)

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Innovative tissue engineering biomimetic hydrogels based on hydrophilic polymers have been investigated for their physical and mechanical properties. 5% to 25% by volume loading PHEMA-nanosilica glassy hybrid samples were equilibrated at 37°C in aqueous physiological isotonic and hypotonic saline solutions (0.15 and 0.05 M NaCl) simulating two limiting possible compositions of physiological extracellular fluids. The glassy and hydrated hybrid materials were characterized both for dynamo-mechanical properties and equilibrium absorptions in the two physiological-like aqueous solutions. Mechanical and the morphological modifications occurring in the samples have been described. The 5% volume nanosilica loading hybrid nanocomposite composition showed mechanical characteristics in the dry and hydrated states that were comparable to those of cortical bone and articular cartilage, respectively, and then chosen for further sorption kinetics characterization. Sorption and swelling kinetics were monitored up to equilibrium. Changes in water activities and osmotic pressures in the water-hybrid systems equilibrated at the two limiting solute molarities of the physiological solutions have been related to the observed anomalous sorption modes using the Flory-Huggins interaction parameter approach. The bulk modulus of the dry and glassy PHEMA-5% nanosilica hybrid at 37°C has been observed to be comparable with the values of the osmotic pressures generated from the sorption of isotonic and hypotonic solutions. The anomalous sorption modes and swelling rates are coherent with the difference between osmotic swelling pressures and hybrid glassy nano-composite bulk modulus: the lower the differences the higher the swelling rate and equilibrium solution uptakes. Bone tissue engineering benefits of use of tuneable biomimetic scaffold biomaterials that can be “designed” to act as biocompatible and biomechanically active hybrid interfaces are discussed.

Preprint REVIEW | doi:10.20944/preprints202408.0526.v1

One Health Ecological Approach in Sustainable Wireless En-ergy Transfer aboard Electric Vehicles for Smart Cities

Adel Razek

Subject: Environmental And Earth Sciences, Sustainable Science And Technology Keywords: One Health; Responsible Attitude; electric vehicles; wireless power transfer; smart cities; living tissues; biodiversity; clean energy

Online: 7 August 2024 (23:09:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0853.v1

Stress-Granules, P-bodies, and Cell Aging: A Bioinformatics Study

Yakov I. Mokin, Nikolay S. Ilyinsky, Semen V. Nesterov, Eugene Y. Smirnov, Olga S. Sergeeva, Anna E. Romanovich, Irina M. Kuznetsova, Konstantin K. Turoverov, Vladimir N. Uversky, Alexander V. Fonin

Subject: Biology And Life Sciences, Life Sciences Keywords: liquid-liquid phase separation; membrane-less organelles; stress granules; P-bodies; intrinsically disordered proteins; intrinsically disordered regions; aging; senescence; protein aggregation; nucleic acids; RNA-binding protein; DNA-binding protein

Online: 14 November 2023 (16:38:59 CET)

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At the molecular level, aging is often accompanied by dysfunction of stress-induced membrane-less organelles (MLOs) and changes in their material state. In this work, we analyzed the proteins included in the proteome of stress granules (SGs) and P-bodies for their tendency to transform the material state of these MLOs. Particular attention was paid to proteins whose gene expression changes during replicative aging. It was shown that the proteome of the studied MLOs practically does not differ in the analyzed characteristics and consists of completely or partially intrinsically disordered proteins, 30 - 40% of which are potentially capable of liquid-liquid phase separation (LLPS). At the same time, the proportion of proteins capable of spontaneous LLPS is relatively small, which indicates the leading role of nucleic acids in the biogenesis of these membrane-less organelles. Proteins whose gene expression changes during the transition of human cells to a senescent state make up about 20% of the studied proteomes. There is a statistically significant increase in the number of positively charged proteins in both datasets studied compared to the complete proteomes of these organelles. An increase in the relative content of DNA-, but not RNA-binding proteins, was also found in the stress-granules dataset with senescence-related processes. Among SG proteins potentially involved in senescent processes, there is an increase in the abundance of potentially amyloidogenic proteins compared to the whole proteome. The hnRPDL protein has the highest degree of disorder and highest propensity for LLPS among such proteins, which allows us to consider it as “potentially dangerous.” Proteins common to SGs and P bodies, potentially involved in processes associated with senescence, form clusters of interacting proteins. The largest cluster is represented by RNA-binding proteins involved in RNA processing and translation regulation. These data indicate that SG proteins, but not proteins of P-bodies, are more likely to transform the material state of MLOs. Furthermore, these MLOs can participate in processes associated with aging in a coordinated manner.

Preprint ARTICLE | doi:10.20944/preprints202408.0987.v1

Molecular Docking Analysis, of Natural Compounds from Cold-Pressed and Essential Oils, Against Human Papillomavirus (HPV): Therapeutic Implications for Gynecological Viral Infections

Momir Dunjic, Stefano Turini, Lazar Nejkovic, Nenad Sulovic, Sasa Cvetkovic, Marija Dunjic, Katarina Dunjic, Dina Dolovac

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: HPV-16, Molecular Docking, Artificial Intelligence, Ethnobotany, Natural Compounds, Antiviral Agents, Luteolin, Apigenin, Pharmacological Screening, Ethnopharmacology, Computer Simula-tions, Laborator

Online: 14 August 2024 (09:07:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0845.v1

Multi-Material Additive Manufacturing of PLLA-HA/GO Scaffold Fabricated via DLP for Bone Loss: Experimental Investigation, Numerical Analysis, and Cell Study

Iman Ghaderi, Amir Hossein Behravesh, Seyyed Kaveh Hedayati, Seyed Alireza Alavinasab Ardebili, Omid Kordi, Ghaus Rizvi, Khodayar Gholivand

Subject: Engineering, Mechanical Engineering Keywords: Multi-Material; Additive Manufacturing; Bone Tissue Engineering; Digital Light Processing; Biomedical Application; Triply Periodic Minimal Surfaces (TPMS)

Online: 14 November 2023 (16:39:35 CET)

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Preprint REVIEW | doi:10.20944/preprints202309.2068.v1

Demand-Oriented Review of Dynamic Energy Loss Monitoring System for Primary School Buildings through Micro-Environmental Data Monitoring and Occupant Behavior Analysis

Zhen Peng, Yanan Yu, Rui Guan

Subject: Engineering, Architecture, Building And Construction Keywords: school buildings; building dynamic energy loss; microenvironment; occupants’ behavior

Online: 30 September 2023 (10:16:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0937.v1

Retrospective Analysis of the Correlation of MSI-H/dMMR Status and Response to Therapy for Endometrial Cancer: RAME Study, a Multicenter Experience

Valentina Tuninetti, Luca Pace, Eleonora Ghisoni, Virginia Quarà, Francesca Arezzo, Andrea Palicelli, Vincenzo Dario Mandato, Elena Geuna, Gennaro Cormio, Nicoletta Biglia, Lucia Borsotti, Silvia Gallo, Annamaria Ferrero, Elena Jacomuzzi, Luca Fuso, Jeremy Oscar Smith Pezua Sanjinez, Andrea Puppo, Andrea Caglio, Chiara Rognone, Margherita Turinetto, Giulia Scotto, Massimo Di Maio, Giorgio Valabrega

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Endometrial cancer; microsatellite instability; mismatch repair deficiency; platinum-based chemotherapy

Online: 13 June 2023 (12:27:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0337.v1

Screening and Validation of Internal Reference Genes for Quan-Titative Real-Time PCR Analysis of Leaf Color Mutants in Den-Drobium Officinale

Hua Cao, Han Li, Lin Lu, Yulu Ji, Lulin Ma, Shenchong Li

Subject: Biology And Life Sciences, Plant Sciences Keywords: Dendrobium officinale; leaf color; qRT-PCR; reference gene; leaf color mutant

Online: 5 May 2023 (09:34:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0099.v2

Analysis of Perception, Reasons, and Motivations for COVID-19 Vaccination in People with Diabetes across Sub-Saharan Africa: A Mixed-Method Approach

Uchechukwu Levi Osuagwu, Raymond Langsi, Godwin Ovenseri-Ogbomo, Khathutshelo Percy Mashige, Emmanuel Kwasi Abu, Esther Awazzi Envuladu, Piwuna Christopher Goson, Bernadine Nsa Ekpenyong, Richard Oloruntoba, Miner Asabe Chundung, Deborah Donald Charwe, Chikasirimobi Goodhope Timothy, Tanko Ishaya, Onyekachukwu Mary-Anne Amiebenomo, David Lim, Kingsley E Agho

Subject: Public Health And Healthcare, Health Policy And Services Keywords: diabetes; survey; sub-Saharan Africa; coronavirus; vaccine; hesitancy; refusal; qualitative; lockdown

Online: 15 June 2022 (05:56:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0311.v1

Microbial Consortia and Mixed Plastic Waste: Pangenomic Analysis Reveals Potential for Degradation of Multiple Plastic Types via Previously Identified PET Degrading Bacteria

Sabrina Edwards, Rosa Leon-Zayas, Riyaz Ditter, Helen Laster, Grace Sheehan, Oliver Anderson, Toby Beattie, Jay L Mellies

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: biodegradation; poly(ethylene)terephthalate (PET); low-density polyethylene (LDPE); plasticizers; mixed-plastics; pangenomes

Online: 30 April 2022 (04:22:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints202107.0198.v1

Tracking the CAR-T Revolution: Analysis of Clinical Trials of CAR-T and TCR Therapies for the Treatment of Cancer (1997-2020)

Nikola Aleksandar Ivica, Colin M Young

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: CAR-T; TCR; cancer immunotherapy; immunotherapy clinical trials

Online: 8 July 2021 (11:04:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0582.v1

Efficacy Analysis of Panchromatic New Copper Complex for Visible Light (455, 530 nm) Radical/Cationic Photopolymerization: The Synergic Effects and Catalytic Cycle

Jui-Teng Lin, Jacques Lalevee, Da-Chun Cheng

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: polymerization kinetics; free radical, cationic polymerization, copper complex, photoredox catalyst.

Online: 23 June 2021 (12:37:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202001.0270.v1

A Cost-minimization Analysis of Provider-to-provider Telemedicine Compared to Usual care in Catalonia: More Agile and Efficient, Especially for Users

Francesc López Seguí, Jordi Franch Parella, Xavier Gironès García, Jacobo Mendioroz Peña, Francesc García Cuyàs, Cristina Adroher Mas, Anna García-Altés, Josep Vidal Alaball

Subject: Business, Economics And Management, Economics Keywords: cost analysis; health technology assessment; provider-to-provider telemedicine; telehealth; economic analysis

Online: 23 January 2020 (16:19:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.1629.v1

Region-Specific Decellularization of Porcine Uterine Tube Extracellular Matrix: A New Approach for Reproductive Tissue-Engineering Applications

Gustavo Henrique Doná Rodrigues Almeida, Raquel Souza da Silva, Mariana Sversut Gibin, Victoria Helen de Souza Gonzaga, Henrique dos Santos, Rebeca Piatniczka Igleisa, Leticia Alves Fernandes, Iorrane Couto Fernandes, Thais Naomi Gonçalves Nesiyama, Franciele Sato, Mauro Luciano Baesso, Luzmarina Hernandes, Jaqueline de Carvalho Rinaldi, Flavio Vieira Meirelles, Claudete S. Astolfi-Ferreira, Antonio José Piantino Ferreira, Ana Claudia Oliveira Carreira

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: uterine tube; extracellular matrix; reproduction; decellularization; biomaterial

Online: 24 May 2024 (11:56:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1858.v1

A Dynamic Simulation of a Piezoelectric Energy Harvesting System Integrated with a Closed-Loop Voltage Source Converter for Sustainable Power Generation

Ahmed K Ali, Ali Abdulwahhab Abdulrazzaq, Ali H. Mohsin

Subject: Engineering, Electrical And Electronic Engineering Keywords: controlled PWM rectifier; P&; O MPPT; closed-loop converter; piezoelectric energy harvesting; sustainable renewable energy

Online: 26 August 2024 (17:08:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1023.v1

A Contribution to the Integration of International, National and Local Cultural Heritage Protection through a Multilevel Approach to Planning: A Case Study of the Djerdap Area

Ana Niković, Božidar Manić, Nataša Čolić Marković, Nikola Krunić

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Djerdap; Danube; spatial plan; protected area; cultural heritage; multilevel approach

Online: 16 April 2024 (10:27:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1972.v1

Integrating Aerial and 3D Data into a Data-Driven Decision-Making Workflow for Nature-Based Stormwater Solutions

Harry Edelman, Lasse Rosen, Emil Nyman, And Piia Leskinen

Subject: Arts And Humanities, Architecture Keywords: aerial; data; drones; urban; nature-based; photogrammetry; design; software; decision-making; stormwater; management

Online: 1 November 2023 (02:43:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0243.v1

Comparisons of Initial Condition Perturbation Methods for Regional Ensemble Forecasts of Wind Speed in Gansu of China

Zifen Han, Diangang Hu, Qingquan Lv, And Xiaohui Zhong

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: ensemble; wind forecast; dynamical downscaling; breeding; blending

Online: 14 February 2023 (09:36:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints201607.0051.v1

Search for QPOs in the Light Curve of the Blazar OJ287: Preliminary Results from 2015/16 Observing Campaign

S. Zola, M. Valtonen, G. Bhatta, A. Goyal, B. Debski, A. Baran, J. Krzesinski, M. Siwak, S. Ciprini, A. Gopakumar, H. Jermak, K. Nilsson, D. Reichart, K. Matsumoto, K. Sadakane, K. Gazeas, M. Kidger, V. Piirola, F. Alicavus, K.S. Baliyan, A. Berdyugin, D. Boyd, M. Campas Torrent, F. Campos, J. Carrillo Gomez, D.B. Caton, V. Chavushyan, J. Dalessio, D. Dimitrov, M. Drozdz, A. Erdem, A. Escartin Perez, V. Fallah Ramazani, A.V. Filippenko, F. Garcia, F. Gomez Pinilla, M. Gopinathan, J.B. Haislip, J. Harmanen, G. Hurst, K.M. Ivarsen, M. Jelinek, A. Joshi, M. Kagitani, N. Kaur, N. Karaman, W.C. Keel, A.P. LaCluyze, B.C. Lee, E. Lindfors, J. Lozano De Haro, J.P. Moore, R. Naves Nogues, A.W. Neely, R.H. Nelson, W. Ogloza, S. Okano, J.C. Pandey, M. Perri, P. Pihajoki, G. Poyner, J. Provencal, T. Pursimo, A. Raj, R. Reinthal, S. Sadegi, T. Sakanoi, J.-L. Salto Gonzales, T. Schweyer, F.C. Soldan Alfaro, E. Sonbas, I. Steele, J.T. Stocke, J. Strobl, L.O. Takalo, T. Tomov, L. Tremosa Espasa, J.R. Valdes, J. Valero Perez, F. Verrecchia, J.R. Webb, M. Yoneda, M. Zejmo, W. Zheng, J. Telting, J. Saario, T. Reynolds, A. Kvammen, E. Gafton, R. Karjalainen, P. Blay

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: galaxies: active; BL Lacertae objects: individual (OJ 287); super massive black holes

Online: 18 July 2016 (10:46:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0712.v1

Prevalence and Genetic Analysis of Porcine Circovirus Type 2 That Circulated between 2014 and 2021 in Jiangsu, China

Qi Xiao, Meng Qu, Jianping Xie, Cigen Zhu, Yuping Shan, Aihua Mao, Wenxian Qian, Jiaping Zhu, Jiahui Guo, Dong Lang, Jiaqiang Niu, Libin Wen, Kongwang He

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: porcine circovirus type 2; Jiangsu Province; genetic analysis; genotype

Online: 9 September 2024 (23:42:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1814.v1

Comparative Study for DC-DC Converter Output Bank’s Reliability Evaluation using Prediction Standards MIL-HDBK-217F vs. TelcordiaSR-332

Dan Butnicu

Subject: Engineering, Electrical And Electronic Engineering Keywords: polymer electrolytic capacitor; prediction standard; reliability; MTBF

Online: 26 June 2024 (08:20:01 CEST)

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In the last decade, a higher level of reliability became a compulsory demand when it comes to modern DC-DC converters. This work addresses the main reliability metrics: the failure rate λλ and MTBF of an output capacitor bank used within a high current low voltage buck converter due to many studies have shown that the output capacitor bank was demonstrated being the most critical component within the converter. Many authors treated this issue, usually by doing reliability predictions. The majority of the papers use only one specific Standard Prediction to solve the problem. Herein calculation was done using both the older standard MIL-HDBK-217 and the latest one Telcordia SR-332, providing a benchmark comparison between the two which is a helpful tool for the output capacitor selection in the early stage design. Military standard was well accepted for decades in order to reliability prediction even on industrial electronics and is still used today under a critical manner because no more update after the latest version MIL-HDBK-217F - Notice 2 released in 1995. Since then, newer prediction standards had appeared in the electronics reliability market. Over time, this standard was mostly used but it does not accurately model the reliability because lack of taking account of mission profile. The above-mentioned newer standard – i.e., Telcordia SR-332 is trying to compensate also the lack of the newest component technology in the older standard (which is the first standard released on the market) supplying useful design data for design engineers who use the so-called “design with the reliability in mind” concept. Within the paper were established the environmental condition for the passive components by means of a PoL (Point of load) buck converter that is used for both calculation methods. The influence of temperature and several specific concepts like reference conditions, operating conditions, ripple, and internal self-heating were taking account in order to display the results. The temperature for the capacitor’s capsule needed in π_T stress factor calculation was derived by PSPICE simulation. High fidelity and dedicated SPICE models provided by the manufacturer were used for MOSFETs, polymer electrolytic, and MLCC capacitors that compose the converter.

Preprint ARTICLE | doi:10.20944/preprints202409.0263.v1

Flagellar Microswimmer with One-point Actuation: Effects of Non-uniform Mass and Elasticity on Propulsion

Moisés Bolívar-Vivas, Andrés Joaquín Serrano-Balbontín, Inés Tejado, Blas M. Vinagre

Subject: Engineering, Control And Systems Engineering Keywords: microrobot; swimmer; one-point actuation; flagellum; flexible; mass; elasticity; distribution; bioinspired

Online: 3 September 2024 (18:14:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0530.v1

Antimalarial Activity of Aqueous Extracts of Nasturtium (Tropaeolum majus L.) and Benzyl Isothiocyanate

Ana Maria Pintão, Tiago Alexandre Pena Santos, Fátima Nogueira

Subject: Medicine And Pharmacology, Tropical Medicine Keywords: Antimalarial; Plasmodium falciparum; Tropaeolum majus L; Benzyl isothiocyanate

Online: 8 March 2024 (12:57:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0585.v1

Nutritional Data on Selected Food Products Consumed in Oman: An Update of the Food Composition Table and Use for Future Food Consumption Surveys

Salima Almaamari, Ayoub Al-Jawaldeh, Ibtisam Al Ghammari, Saleh Al Shammakhi, Jokha Al Aamri, Jalila El Ati

Subject: Public Health And Healthcare, Health Policy And Services Keywords: laboratory values; nutrition label; ultra-processed products; NOVA system; nutrient profile; FoodEx2 system; traffic light label

Online: 9 February 2024 (11:45:11 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202401.1706.v1

Comparative Clinical Evaluation of 3 Artificial Intelligence Algorithms for Breast Cancer Screening with Mammography

Alexandra Brion, Lan-Anh Dang, Edouard Poncelet, Laurie Ferret, Mathilde Vermersch, Laurent Nicolas

Subject: Medicine And Pharmacology, Other Keywords: Breast neoplasia; Artificial intelligence; ; Algorithm; ; Mammography

Online: 24 January 2024 (07:16:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0928.v1

Silver-Assisted Hydrogen Evolution from Aluminum Oxidation in Saline Media

Olesya A. Buryakovskaya, Konstantin I. Maslakov, Nikita O. Borshchev, Grayr N. Ambaryan, Aleksey V. Butyrin, Mikhail S. Vlaskin

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: aluminum-silver powder; gallium; lithium chloride; high energy ball milling; aqueous chlorine solution; hydrogen generation.

Online: 11 January 2024 (13:17:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1676.v1

Harnessing Multistability: A Novel Approach to Optical Logic Gate Construction Using Erbium-Doped Fiber Lasers

Safara Bibi, José Luis Echenausía-Monroy, Rider Jaimes-Reátegui, Juan Hugo García-López, Guillermo Huerta-Cuellar, Alexander N. Pisarchik

Subject: Physical Sciences, Optics And Photonics Keywords: multistate Intermittency; multistability; erbium-doped fiber laser; detrended fluctuation analysis; logic operations; logic gates.

Online: 21 December 2023 (16:00:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0970.v1

One Step Closer to Enigmatic USCα Methanotrophs: Isolation of a Methylocapsa-Like Bacterium from a Subarctic Soil

Olga V. Danilova, Igor Y. Oshkin, Svetlana E. Belova, Kirill K. Miroshnikov, Anastasia A. Ivanova, Svetlana N. Dedysh

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: atmospheric methane consumption; polar regions; methanotrophic bacteria; Methylocapsa; USCα group.

Online: 16 October 2023 (16:56:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1913.v1

Reverse Onco-Cardiology: What Is the Evidence for Breast Cancer? A Systematic Review of the Literature

IOANNIS BOUTAS, Adamantia Kontogeorgi, Sophia N Kalantaridou, Constantine Dimitrakakis, Panagiotis Patsios, Maria Kalantzi, Theodoros Xanthos

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: breast cancer; cardiovascular Disease; hypertension; atrial Fibrillation; myocardial Infarction

Online: 28 September 2023 (18:13:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1826.v1

Single Crystal Structure Analysis of Three Novel Iron(II) Coordination Polymers with Bridging 1,3,5-Tris(1H-1,2,4-triazol-1-yl)methyl)benzene

Aysenur Limon, Dustin N. Jordan, Till Strothmann, Laure P. Cuignet, Yann Garcia, Christoph Janiak

Subject: Chemistry And Materials Science, Inorganic And Nuclear Chemistry Keywords: coordination polymers; coordination networks; triazole ligand; iron(II); self-assembly; hydrogen bonds

Online: 27 September 2023 (07:17:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1242.v1

Encapsulated Phytase Produced by Recombinant Yarrowia lipolytica Exhibits High Efficiency on Quails at Low Doses

Ekanerina A. Ovseychik, Olga I. Klein, Natalia N. Gessler, Yulia I. Deryabina, Valery S. Lukashenko, Elena P. Isakova

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: phytase; microencapsulation; quail; feed additive; nutrient digestibility; Yarrowia lipolytica; Obesumbacterium proteus

Online: 17 August 2023 (09:10:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.2054.v1

Genomic Characterization of IMP-Producing Pseudomonas aeruginosa in Bulgaria Reveals the Emergence of IMP-100, a Novel Plasmid-Mediated Variant Coexisting with a Chromosomal VIM-4

Ivan Stoikov, Ivan N. Ivanov, Deyan Donchev, Deana Teneva, Elina Dobreva, Rumyana Hristova, Stefana Sabtcheva

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Pseudomonas; metallo-beta-lactamase; blaIMP; novel allele; plasmid

Online: 31 July 2023 (04:53:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.2015.v1

Conservative Tryptophan Residue in the Vicinity of an Active Site of the M15 Family L, D-peptidases: A Key Element in the Catalysis

Galina V. Mikoulinskaia, Dmitry A. Prokhorov, Sergei V. Chernyshov, Daria S. Sitnikova, Arina G. Arakelian, Vladimir N. Uversky

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: L,D-peptidase; bacteriophage; catalysis; substrate binding; calcium

Online: 28 July 2023 (12:29:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1325.v1

Agile Methodology for the Standardization of Engineering Requirements using Large Language Models

Archana Tikayat Ray, Bjorn F Cole, Olivia J Pinon Fischer, Anirudh Prabhakara Bhat, Ryan T White, Dimitri N Mavris

Subject: Engineering, Aerospace Engineering Keywords: Requirements Engineering; Natural Language Processing; NLP; BERT; Requirements boilerplates; Model-Based Systems Engineering; MBSE; Requirements table; Large Language Models (LLMs); Transformer based language models

Online: 18 May 2023 (10:19:18 CEST)

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The increased complexity of modern systems is calling for an integrated and comprehensive approach to system design and development and in particular, a shift towards Model-Based Systems Engineering (MBSE) approaches for system design. The requirements that serve as the foundation for these intricate systems are still primarily expressed in Natural Language (NL), which can contain ambiguities and inconsistencies that hinder their direct translation into models. The colossal developments in the field of Natural Language Processing (NLP) in general and Large Language Models (LLMs) in particular can serve as an enabler for the conversion of NL requirements into semi-machine-readable requirements. This is expected to facilitate their standardization and use in a model-based environment. This paper discusses a two-fold strategy for converting NL requirements into semi-machine-readable requirements using language models. The first approach involves creating a requirements table by extracting information from free-form NL requirements. The second approach is an agile methodology that facilitates the identification of boilerplate templates for different types of requirements based on observed linguistic patterns. For this study, three different LLMs were utilized. Two of these models were fine-tuned versions of Bidirectional Encoder Representations from Transformers (BERT), specifically aeroBERT-NER and aeroBERT-Classifier, which were trained on annotated aerospace corpora. Another LLM, called flair/chunk-english, was utilized to identify sentence chunks present in NL requirements. All three language models were utilized together to achieve the standardization of requirements. To demonstrate the effectiveness of the methodologies, requirements from Parts 23 and 25 of Title 14 Code of Federal Regulations (CFRs) were employed, and a total of two, five, and three boilerplate templates were identified for design, functional, and performance requirements, respectively.

Preprint ARTICLE | doi:10.20944/preprints202304.0902.v1

Assessment of the Prevalence of Subclinical Mastitis in Dual Purpose Livestock System of Colombian Orinoquia: On-Farm Diagnostic Tests Comparison

Arcesio Salamanca Carreño, Mauricio Vélez-Terranova, Rita Taamasaukas, Raúl Jáuregui-Jiménez, Pere M. Parés-Casanova, José N. Arias-Landazábal

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: hand milking; inflammation; public health; udder health

Online: 25 April 2023 (08:35:22 CEST)

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