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Preprint ARTICLE | doi:10.20944/preprints202404.0026.v1

Molecular Prevalence, Genetic Diversity, and Tissue Tropism of Bartonella Species in Small Mammals from Yunnan Province, China

Pei-Yu Han, Fen-Hui Xu, Jia-Wei Tian, Jun-Ying Zhao, Ze Yang, Wei Kong, Bo Wang, Li-Jun Guo, Yun-Zhi Zhang

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Bartonella; small mammals; genetic diversity; evolution; tissue tropism

Online: 1 April 2024 (17:07:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201707.0047.v1

Genetic Structure and Eco-Geographical Differentiation of Wild Sheep Fescue (Festuca ovina L.) in Xinjiang, Northwest China

Chenglin Zhang, Jianbo Zhang, Yan Fan, Ming Sun, Wendan Wu, Wenda Zhao, Xiaopeng Yang, Linkai Huang, Yan Peng, Xiao Ma, Xinquan Zhang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Festuca ovina L.; AFLP, genetic diversity; genetic barriers; environmental factors

Online: 18 July 2017 (10:05:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0284.v1

Building Consensus around the Assessment and Interpretation of Symbiodiniaceae Diversity

Sarah Davies, Matthew H. Gamache, Lauren I. Howe-Kerr, Nicola G. Kriefall, Andrew C. Baker, Anastazia T. Banaszak, Line K. Bay, Anthony J. Bellantuono, Debashish Bhattacharya, Cheong Xin Chan, Danielle C. Claar, Mary Alice Coffroth, Ross Cunning, Simon K. Davy, Javier del Campo, Erika M. Diaz-Almeyda, Jorg C. Frommlet, Lauren E. Fuess, Raul A. Gonzalez-Pech, Tamar L. Goulet, Kenneth D. Hoadley, Emily J. Howells, Benjamin C. C. Hume, Dustin W. Kemp, Carly, D. Kenkel, Sheila A. Kitchen, Todd C. LaJeunesse, Senjie Lin, Shelby McIlroy, Ryan McMinds, Matthew R. Nitschke, Clinton A. Oakley, Raquel S. Peixoto, Carlos Prada, Hollie M. Putnam, Kate Quigley, Hannah G. Reich, James Davis Reimer, Mauricio Rodriguez-Lanetty, Stephanie Rosalas, Osama S. Saad, Eugenia M. Sampayo, Scott Santos, Eiichi Shoguchi, Edward G. Smith, Michael Stat, Timothy G. Stephens, Marie E. Strader, David J. Suggett, Timothy D. Swain, Cawa Tran, Nikki Traylor-Knowles, Christian R. Voolstra, Mark E. Warner, Virginia M. Weis, Rachel Wright, Tingting Xiang, Hiroshi Yamashita, Maren Ziegler, Adrienne M.S. Correa, John Everett Parkinson

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Symbiodinaceae; genetic diversity; coral symbiosis

Online: 21 June 2022 (04:49:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0481.v1

IRAPs in Combination with Highly Informative ISSRs Confer Effective Potentials for Genetic Diversity and Fidelity Assessment in Rhododendron

Sulin Wen, Hong Zhao, Manying Zhang, Guang Qiao, Xiaohui Shen

Subject: Biology And Life Sciences, Plant Sciences Keywords: genetic fidelity; genetic diversity; IRAP; ISSR; Rhododendron

Online: 28 March 2023 (09:56:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1134.v1

Investigating Genetic Diversity and Population Structure in Rice Breeding from Association Mapping of 116 Accessions Using 64 Polymorphic SSR Markers

Alok kumar Singh, Devendra Kumar, Donato Gemmati, Ranjith Kumar Ellur, Ashutosh Singh, Veronica Tisato, D.K. Dwivedi, Sanjay Kumar Singh, Kishor Kumar Sadasivuni, Nawaz Ahmad Khan, Ajay Vikram Singh

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Rice; Population structure; Genetic diversity; PIC; Association mapping; Variability

Online: 20 March 2024 (04:45:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1729.v1

Assessment of Diversity and Genetic Variability of Guava (Psidium guajava) by Means of Microsatellite Markers in Montería, Córdoba-Colombia

Enrique Pardo-Perez, Elizabeth Ramos-Rivero, Luis Causil-Vargas

Subject: Biology And Life Sciences, Life Sciences Keywords: genetic diversity; genetic variability; microsatellites; allele frequencies; population structure

Online: 28 November 2023 (08:08:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0010.v1

Genetic Diversity and Population Structure of the Invasive Oriental Fruit Fly, Bactrocera dorsalis (Diptera: Tephritidae) in Burkina Faso

Nouhoun Traoré, Mahamadi Kientega, Hamidou Maïga, Karim Nebié, Issaka Zida, Roberto Galizi, Emmanuel Kiendrebeogo, Bazoumana BD Sow, Adrien M. G. Belem, Remy A. Dabiré, Abdoulaye Diabaté

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: genetic diversity; genetic structure; microsatellite markers; Bactrocera dorsalis; Burkina Faso

Online: 1 March 2024 (07:57:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202410.2604.v1

Genetic Diversity and Population Structure of Tomato (Solanum lycopersicum)

Ibtisam Alatawi, Haizheng Xiong, Hanan Alkabkabi, Kenani Chiwina, Qun Luo, Kai-Shu Ling, Yuejun Qu, Renjie Du, Ainong Shi

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: tomato; Solanum lycopersicum; single nucleotide polymorphism (SNP); population structure; genetic diversity

Online: 1 November 2024 (14:57:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints201911.0349.v1

Genetic Diversity of Bemisia tabaci (Gennadius) (Hemiptera:Aleyrodidae) Colonizing Sweet Potato and Cassava in South Sudan

Beatrice Clarence Misaka, Everlyne N. Wosula, Philip W. Marchelo-d'Ragga, Trine Hvoslef-Eide, James Peter Legg

Subject: Biology And Life Sciences, Forestry Keywords: Bemisia tabaci; genetic diversity; distribution; haplotype

Online: 28 November 2019 (03:24:39 CET)

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Working Paper HYPOTHESIS

Human Genetic Diversity Possibly Determines Human's Compliance to COVID-19

Yiqiang Zhao, Yunchun Gu, Yongji Liu, Sa Li, Yuzhan Wang, Lina Bu, Qi Liu, Hongyi Lv, Fang Wan, Lida Wu, Zemin Ning

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: COVID-19; severe symptoms; inactivation; genetic diversity

Online: 16 April 2020 (09:15:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0465.v1

Genetic Diversity and Population Structure of a Rhodes Grass (Chloris gayana) Collection

Alemayehu Teressa Negawo, Meki S. Muktar, Yilikal Assefa, Jean Hanson, Alieu M. Sartie, Ermias Habte, Chris S. Jones

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: DArTSeq markers; genetic diversity; Rhodes grass (Chloris gayana); subset

Online: 20 May 2021 (09:46:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0359.v1

Genomic Diversity and Evolution, Diagnosis, Prevention, and Therapeutics of the Pandemic COVID-19 Disease

M. Nazmul Hoque, Abed Chaudhury, Md. Abdul Mannan Akanda, M. Anwar Hossain, Md Tofazzal Islam

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: SARS-CoV-2; genetic diversity; genome evolution; diagnostics; therapeutics; vaccines

Online: 20 April 2020 (02:33:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1960.v1

Directional Breeding Generates Distinct Genetic Diversity in Hybrid Turf Bermudagrass as Probed with SSR Markers

Desalegn D. Serba, Tilin Fang, Yanqi Wu

Subject: Biology And Life Sciences, Plant Sciences Keywords: C. dactylon; C. transvaalensis; interspecific hybrids; cluster analysis; genetic similarity; genetic diversity; directional breeding

Online: 29 May 2023 (08:55:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.1401.v1

Crafting Genetic Diversity: Unlocking the Potential of Protein Evolution

Vamsi Krishna Gali, Kang Lan Tee, Tuck Seng Wong

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Protein engineering; directed evolution; genetic diversity; random mutagenesis; molecular cloning

Online: 19 December 2023 (10:45:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0826.v1

SSR Based Genetic Diversity Analysis and Population Structure of Proso millet (Panicum miliaceum L.) in Kazakhstan

Meisam Zargar, Elmira Dyussibayeva, Aidyn Orazov, Aiym Zeinullina, Irina Zhirnova, Gulzat Yessenbekova, Aiman Rysbekova

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: proso millet collection; genetic diversity; SSR markers; agronomic traits

Online: 13 September 2023 (10:37:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0340.v1

Prevalence, Phylogroups, Antimicrobial Susceptibility and GE-Netic Diversity of Escherichia coli Isolates From Food Products

Babak Pakbin, Samaneh Allahyari, Zahra Amani, Wolfram Manuel Bruck, Razzagh Mahmoudi, Amir Peymani

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Escherichia coli; Antimicrobial resistance; Food samples; Phylogenetic group; Genetic diversity

Online: 16 August 2021 (13:35:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.1118.v1

Novel Genetic Variants Expand the Functional, Molecular and Pathological Diversity of KCNA1 Channelopathy

Kelsey Paulhus, Edward Glasscock

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: KCNA1; Kv1.1; epilepsy; episodic ataxia; myokymia; SUDEP; respiration; genetic modifiers; musculoskeletal; nystagmus

Online: 28 April 2023 (04:59:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0304.v1

Longitudinal Survey of Coronavirus Circulation and Diversity in Insectivorous Bat Colonies in Zimbabwe

Vimbiso Chidoti, Helene De Nys, Valerie Pinarello, Getrude Mashura, Dorothee Misse, Laure Guerrini, Davies Pfukenyi, Julien Cappelle, Ngoni Chiweshe, Ahidjo Ayouba, Gift Matope, Martine Peeters, Elizabeth Gori, Mathieu Bourgarel, Florian Liegeois

Subject: Biology And Life Sciences, Virology Keywords: Bat Coronavirus (Bt CoVs); human-bat interaction; genetic diversity; reproductive phenology; Zimbabwe

Online: 23 March 2022 (02:55:01 CET)

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Preprint REVIEW | doi:10.20944/preprints202203.0295.v1

Genetic Diversity of Schistosoma Haematobium in Sub-Saharan Africa: A Systematic Review

Rabecca Tembo, Panji Nkhoma, Mildred Zulu, Florence Mwaba, John Yabe, Hikabasa Halwiindi, Moses Kamwela, King S. Nalubamba, Chummy S. Sikasunge, Andrew M. Phiri

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Urinary schistosomiasis; Schistosoma haematobium; sub-Saharan Africa; Genetic Diversity

Online: 22 March 2022 (04:25:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.0613.v1

Assessment of Genetic Diversity in Winged Bean [Psophocarpus Tetragonolobus (L.) DC.] Accessions Using Morphological Traits and Microsatellite Markers

Temitope Esther Olatunde, Adeolu Moses Adebayo, Ayomide Ajoke Bhadmus, Idris Ishola Adejumobi, Olaniyi Oyatomi, Benjamin Faloye, Michael Abberton

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Accessions; genetic diversity; morphological traits; SSRs; winged bean

Online: 8 June 2023 (09:25:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201711.0079.v1

Cryptic Species Diversity of Rice Hopper Parasitoids in Southeast Asia

Christina Sann, Franziska Wemheuer, Alexis Beaurepaire, Rolf Daniel, silvio Erler, Stefan Vidal

Subject: Biology And Life Sciences, Insect Science Keywords: DNA barcoding; genetic diversity; hymenopteran parasitoids; Nephotettix spp.; Nilaparvata lugens; rice

Online: 13 November 2017 (17:06:38 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints201912.0176.v1

A Framework for Maximising the Capture of Genetic Diversity in Sampling for ex situ Conservation

Linda Neaves

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: conservation; genetic diversity; decision-making; ex situ

Online: 12 December 2019 (12:43:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1514.v1

Genetic Diversity, Pathogenicity and Host Resistance of Fusarium Species from Soybean in Canada

Longfei Wu, Sheau-Fang Hwang, Stephen E. Strelkov, Rudolph Fredua-Agyeman, Sanghoen Oh, Richard R. Bélanger, Owen Wally, Yong Min Kim

Subject: Biology And Life Sciences, Plant Sciences Keywords: Fusarium spp.; genetic diversity; pathogenicity; phylogenetic analyses; resistance; root rot; Sanger sequencing; soybean

Online: 23 November 2023 (11:06:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1048.v1

Integrated identification and Genetic diversity of the Invasive Clearwing moths (Lepidoptera: Cossidae: Sesiinae) in Korea

Sora Kim, Jong-Kook Jung, Ikju Park, Bong-Woo Lee, Yong-Hun Kim

Subject: Biology And Life Sciences, Insect Science Keywords: invasive insect pests; regional populations; genetic divergence; COI; street insect pests

Online: 14 December 2023 (06:01:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.1578.v1

Genetic Diversity Analysis of Guangxi Kumquat (Fortunella Swing) Germplasm Using SRAP Molecular Markers

Binghao Liu, Ping Ding, Rongchun Ye, Yi Li, Shanhan Ou, Alessandra Gentile, Xianfeng Ma, Ziiu Deng

Subject: Biology And Life Sciences, Horticulture Keywords: Guangxi kumquat; Germplasm resources; Diversity; SRAP markers; Genetic analysis

Online: 23 May 2023 (05:06:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0354.v1

Trichoderma: Population Structure and Genetic Diversity of Species with High Potential for Biocontrol and Biofertilizer Applications

Adnan Ismaiel, Dilip Kumar Lakshman, Prashant P Jambhulkar, Daniel P Roberts

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: biocontrol agent; biofertilizer; sustainable agriculture; Trichoderma species; population structure and genetic diversity

Online: 6 February 2024 (13:15:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints201808.0268.v1

Composition and Genetic Diversity of the Nicotiana tabacum Microbiome in Different Topographic Areas and Growth Periods

Xiaolong Yuan, Xinmin Liu, Yongmei Du, Guoming Shen, Zhongfeng Zhang, Jinhai Li, Peng Zhang

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Nicotiana tabacum; Topographic; Growth period; Fungal community composition; Genetic Diversity; ITS1 region

Online: 15 August 2018 (10:51:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0162.v1

Genetic Diversity and Population Structure of Capirona (Calycophyllum spruceanum Benth.) from the Peruvian Amazon Assessed by RAPD Markers

Carla Saldaña, Johan Cancan, Wilbert Cruz, Mirian Correa, Miriam Ramos, Eloy Cuellar, Carlos Arbizu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Amazon forest; capirona; molecular markers; genetic diversity; population structure

Online: 7 June 2021 (10:06:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0278.v1

Genetic Diversity Assessment of Winged Bean Accessions Using Agronomic and Seed Morphometric Traits

Ayomide Ajoke Bhadmus, Michael Terrence Abberton, Emmanuel Ohiosinmuan Idehen, Ukoabasi Ekanem, Rajneesh Paliwal, Olaniyi A. Oyatomi

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Genetic diversity; Underutilized legume; Multispectral imaging system; Agro-morphological traits; Winged bean; Morphometric traits

Online: 15 March 2023 (10:04:35 CET)

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The winged bean is an underutilized legume that has the potential to contribute to nutrition and food security globally, especially in sub-Saharan Africa (SSA). However, very little research attention is paid to exploiting its full potential due to a lack of adequate knowledge of the existing genetic diversity in the available winged bean germplasm. To bridge this gap, seed morphometric and selected agro-morphological traits which are crucial for yield and seed quality determination in crop plants were used to assess the genetic diversity of thirty accessions of winged bean sourced from the Gene bank of the International Institute of Tropical Agriculture (IITA), Ibadan. The thirty winged accessions were evaluated under field trials at three agro-ecological zones in Nigeria. The agro-morphological data as well as the seed morphometric dataset obtained from a Multi-Spectral Imaging (MSI) system were subjected to Analysis of Variance (ANOVA), Principal Component (PC) analysis, cluster analysis, and correlation analysis. Significant differences (p < 0.05) were observed among the accessions for all measured traits. The first three PCs accounted for 93% of the variation observed among the accessions for all measured traits. Accessions were grouped into three clusters based on the agro- morphological traits and three clusters under the MSI system. Seed yield per plant had the highest estimates of significant positive correlation with hundred seed weight, pod weight per plant, etc. at both phenotypic and genotypic levels. TPt-31 had the highest seed yield per plant, pod weight per plant, and early maturity while TPt-7 had an extended flowering and maturity period, the highest number of pods per peduncle and pods per plant as well as the lowest seed yield. These accessions could serve as a good resource for future winged bean improvement programs. The result also confirmed that the MSI system is an invaluable tool for discriminating among accessions of the same crop species.

Preprint ARTICLE | doi:10.20944/preprints202101.0173.v1

Molecular Epidemiology Surveillance of SARS-Cov-2: Mutations and Genetic Diversity One Year After Emerging

Alejandro Flores-Alanis, Armando Cruz-Rangel, Flor Rodríguez-Gómez, James González, Carlos Alberto Torres-Guerrero, Gabriela Delgado, Alejandro Cravioto, Rosario Morales-Espinosa

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: SARS-CoV-2; genetic diversity; molecular surveillance; natural selection; non-synonymous substitution

Online: 11 January 2021 (09:50:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1730.v1

Genetic Diversity of Human Norovirus in Children Less Than 5 Years of Age With Acute Gastroenteritis in Rural Communities in the Gambia

Sheriffo Jagne, M. Jahangir Hossain, Martin Antoni, Abdul Karim Sesay, Muhammed Khalie Abdul, Nuredin I. Mohammed, Madikay Senghore, Alansana Darboe, Jarra Manneh, Abdoulie Kanteh, Dam Khan, Saikou Y Bah, Ndaw Sylvanus Peter, Osbourne Quaye, George Enyimah Armah

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Norovirus genetic diversity genogroups genotypes

Online: 24 January 2024 (10:15:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0395.v1

Nutraceutical Content and Genetic Diversity Share a Common Pattern in New Pomegranate Genotypes

Carmen Arlotta, Valeria Toscano, Claudia Genovese, Pietro Calderaro, Giuseppe Diego Puglia, Salvatore Antonino Raccuia

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Punica granatum L.; Bio-agronomic traits; Antioxidant activity; Total phenolic content; Carbohydrates; Minerals; genetic diversity

Online: 23 December 2021 (14:12:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0494.v1

Genetic Diversity and Population Structure of Anopheles funestus in western Kenya Based on Mitochondrial DNA Marker mtDNA-COII

Isaiah Debrah, Kevin O. Ochwedo, Wilfred O. Otambo, Maxwell G. Machani, Edwin O. Magomere, Shirley A. Onyango, Daibin Zhong, Linda Eva Amoah, Andrew Karanja Githeko, Yaw Asare Afrane, Guiyun Yan

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Anopheles funestus; western Kenya; mtDNA-COII; genetic diversity; gene flow

Online: 27 January 2023 (06:46:32 CET)

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Preprint REVIEW | doi:10.20944/preprints202308.0138.v1

What about Current Diversity of Mycolactone-Producing Mycobacteria: Implication for the Diagnosis and Treatment of Buruli Ulcer

Marine Combe, Emira Cherif, Romain Blaizot, Damien Breugnot, Rodolphe Elie Gozlan

Subject: Biology And Life Sciences, Life Sciences Keywords: buruli ulcer; Mycobacterium ulcerans; DNA; cryptic biodiversity; genetic diversity; antibiotherapy; diagnosis

Online: 2 August 2023 (04:27:14 CEST)

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The identification of an emerging pathogen in humans can remain difficult by conventional methods such as enrichment culture assays that remain highly selective, require appropriate medium and cannot avoid misidentifications, or serological tests that use surrogate antigens and are often hampered by the level of detectable antibodies. Although not originally designed for this purpose, the implementation of polymerase-chain-reaction (PCR) has resulted in an increasing number of diagnostic tests for many diseases. However, the design of specific molecular assays relies on the availability and reliability of published genetic sequences for the target pathogen as well as enough knowledge on the genetic diversity of species and/or variants giving rise to the same disease symptoms. Usually designed for clinical isolates, molecular tests are often not suitable for environmental samples in which the target DNA is mixed with a mixture of environmental DNA. A key challenge of such molecular assays is thus to ensure high specificity of the target genetic markers when focusing on clinical and environmental samples in order to follow the dynamics of disease transmission and emergence in humans. Here we focus on Buruli ulcer (BU), a human necrotizing skin disease mainly affecting tropical and subtropical areas, commonly admitted to be caused by Mycobacterium ulcerans worldwide although other mycolactone-producing mycobacteria and even mycobacterium species were found associated with BU or BU-like cases. By revisiting the literature, we show that many studies have used non-specific molecular markers (IS2404, IS2606, KR) to identify M. ulcerans from clinical and environmental samples and propose that all mycolactone-producing mycobacteria should be definitively considered as variants from the same group rather than different species. Importantly, we provide evidence that the diversity of mycolactone-producing mycobacteria variants as well as mycobacterium species potentially involved in BU or BU-like skin ulcerations might have been underestimated. We also suggest that the specific variants/species involved in each BU or BU-like case should be carefully identified during the diagnosis phase, either via the key of genetic identification proposed here or by broader metabarcoding approaches, in order to guide the medical community in the choice for the most appropriate antibiotic therapy.

Preprint ARTICLE | doi:10.20944/preprints202405.0449.v1

Assessment of genetic diversity and population structure of Fusarium species from the Fusarium fujikuroi species complex causing Fusarium stalk rot of maize

Prashant Jambhulkar, Ruchira Bajpai, J. Harish, Partha Sarathi Tripathy, Ajaya Kumar Rout, Priyanka Varun, Bijay Kumar Behera, Dilip Kumar Lakshman, Mallikarjuna N

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: FSR; Fusarium; Haplotypes; DNA polymorphism; genetic diversity; maize

Online: 8 May 2024 (15:36:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0321.v1

Whole Genome Diversity, Population Structure and Linkage Disequilibrium Analysis of Chickpea (Cicer arietinum L.) Genotypes Using Genome-Wide DArTseq-Based SNP Markers

Somayeh Farahani, Mojdeh Maleki, Rahim Mehrabi, Homayoun Kanouni, Reza Talebi

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: chickpea; genetic diversity; linkage disequilibrium; DArTseq-SNP markers

Online: 29 April 2019 (07:56:52 CEST)

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Characterization of genetic diversity, population structure and linkage disequilibrium is prerequisite for proper management of breeding programs and conservation of genetic resources. In this study, 186 chickpea genotypes including advanced “Kabuli” breeding lines and Iranian landrace “Desi” chickpea genotypes were genotyped using DArTseq-Based SNP markers. Out of 3339 SNPs, 1152 markers with known chromosomal position were selected for genome diversity analysis. The number of mapped SNP markers varied from 52 (LG8) to 378 (LG4), with an average of 144 SNPs per linkage group. The chromosome size that covered by SNPs varied from 16236.36 kbp (LG8) to 67923.99 kbp (LG5), while LG4 showed higher number of SNPs, with an average of 6.56 SNPs per Mbp. Polymorphism information content (PIC) value of SNP markers ranged from 0.05 to 0.50, with an average of 0.32, while the markers on LG4, LG6 and LG8 showed higher mean PIC value than average. Un-weighted Neighbor Joining cluster analysis and Bayesian-based model population structure grouped chickpea genotypes into four distinct clusters. Principal component analysis (PCoA) and Discriminant Analysis of Principal Component (DAPC) results were consistent with that of the cluster and population structure analysis. Linkage disequilibrium (LD) was extensive and LD decay in chickpea germplasm was relatively low. A few markers showed r²≥0.8, while 2961 pairs of markers showed complete LD (r²=1) and a huge LD block was observed on LG4. High genetic diversity and low kinship value between pairs of genotypes suggesting the presence of a high genetic diversity among studied chickpea genotypes. This study also demonstrated the efficiency of DArTseq-based SNP genotyping for large scale genome analysis in chickpea. The genotypic markers provided in this study are useful for various association mapping studies when combined with phenotypic data of different traits such as seed yield, abiotic and biotic stresses and therefore can be efficiently used in breeding programs to improve chickpea.

Preprint ARTICLE | doi:10.20944/preprints201910.0209.v1

Agronomic Practices, Genetic Diversity and Population Structure of Moringa oleifera (Lam.) in Nigeria

Jacob Popoola, David Igwe, Opeyemi Jegede, Victoria Iwu, Adegoke Adegbite, Conrad Omonhinmin

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: agronomic practices; agrobiodiversity; aflp; climate change; cluster analysis; genetic diversity; moringa oleifera; food and nutrition security

Online: 18 October 2019 (07:34:50 CEST)

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Evaluation of agronomic practices, genetic diversity and population structure of Moringa oleifera (Lam.) is crucial to its sustainable utilization to ensure food and nutritional security. Four agronomic practices of field preparation and soil analysis, regeneration, weeding and pruning, as well as harvesting, were adopted. Genetic diversity and population structure of 20 populations were evaluated using amplified fragment length polymorphism (AFLP) primer pairs (E-ACC/M-CAC and E-ACA/M-CAG). The effects of agronomic practices on leaf quantity production were evaluated using standard procedures. The physico-chemical and morphological data were analyzed using descriptive statistics, while genetic diversity, population structure, dendrogram reconstruction, and Principal Component Analysis (PCA) were analyzed from the AFLP genetic data. Significant effects (P ≤ 0.05) of agronomic practices on the quantity of leaf production were recorded across the accessions. The two primer pairs generated a total of 80 alleles with a mean major allele frequency of 0.0250. Gene diversity and polymorphic information content (PIC) values were high with a mean of 0.98 and 0.974, respectively. The Gst value of 0.0490 indicated that 5 % of the total genetic divergence was among the population while 95 % within the population. Dendrogram reconstruction with genetic distance ranging from 0.87 to 0.96 segregated the accessions into eleven clusters while PCA generated six cluster groups. Field preparation and physico-chemical soil properties, regeneration, weeding and pruning, and stand development, as well as harvesting, influenced the leaf yield and genetic diversity observed in this study. The genetic data revealed that some accessions were clustered along eco-geographical lines while others grouped disparately. Identified potential parent genotypes with valuable and desirable genetic traits can be exploited for commercial, breeding and conservation purposes to ensure sustainable utilization of the species in Nigeria.

Working Paper ARTICLE

Assessment of Genetic Diversity of Dioscorea praehensilis (Berth.) Collected from Central Region, Ghana Using Simple Sequence Repeat (SSR) Markers

Adeyinka S. Adewumi, Kingsley J. Taah, Paul A. Asare, Michael O. Adu, Paterne A. Agre

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: genetic diversity; Dioscorea praehensilis; SSR markers; Ghana

Online: 8 March 2020 (14:55:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1304.v1

Assessment of Genetic Diversity and Phylogenetic Relationship of Local Coffee Populations in Southwestern Saudi Arabia using DNA Barcoding

Habib Khemira, Mosbah Mahdhi, Muhammad Afzal, Mohammed Oteef, Taieb Tounekti, Zarraq Al-Faifi, Wail Alsolami

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Coffea arabica; chloroplastic DNA; barcode, genetic diversity; population structure; Saudi Arabia

Online: 19 June 2023 (05:40:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0614.v1

Population Structure and Genetic Diversity of Ajuga Arabica in Saudi Arabia: A Comparative Analysis of DNA and Gene Sequences

Mohammad Odah

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Ajuga arabica, Genetic Diversity, Population Structure, DNA Sequence, Gene Sequence.

Online: 11 March 2024 (11:02:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0644.v1

Study on the Genetic Diversity of Germplasm Resources of Characteristic Medicinal Orchid Plant Habenaria dentata

Yi shan Yang, Jian min Tang, Rong Zou, Yajin Luo, Zhenhai Deng, Dongxin Li, Shengfeng Chai, Xiao Wei

Subject: Biology And Life Sciences, Other Keywords: Habenaria dentata; medicinal orchid plant; genetic diversity; ISSR; cluster analysis

Online: 11 July 2023 (03:11:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0144.v1

ISSR-Markers Assisted Genetic Diversity Assessment of Acid Lime [Citrus aurantifolia (Christm.) Swingle] Germplasm of Eastern Nepal

Nabin Narayan Munankarmi, Neesha Rana, Tribikram Bhattarai, Ram Lal Shrestha, Bal Krishna Joshi, Bikash Baral, Sangita Shrestha

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: citrus breeding; diversity; genetic similarity; Lime; molecular markers; PCR

Online: 9 May 2018 (11:05:37 CEST)

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Acid lime [Citrus aurantifolia (Christm.) Swingle] is a fruit crop, enriched with high commercial value and is cultivated in 60 out of 75 districts representing all geographical landscapes of Nepal. Lack of high yielding cultivars is probably one of the main reason for its extremely reduced productivity which warrants a deep understanding of genetic diversity in existing germplasm. Hereby, we aim to access the genetic diversity of acid lime germplasm cultivated at 3-different ecological gradients of eastern Nepal employing PCR-based Inter-Simple Sequence Repeats markers (ISSR). Altogether, 21 polymorphic ISSR markers were used to assess the genetic diversity in 60 acid lime cultivars sampled from different geographical locations. Analysis of binary data matrix was performed on the basis of bands obtained, scoring of the data was done accordingly, and principal coordinate analysis and phenogram were constructed using different computer algorithms. ISSR profiling yielded 234 amplicons, of which 87.18% were found to be polymorphic. The number of amplified fragments ranged from 7-18 with amplicon size ranging from 250-3200 bp. The NTSYS based Cluster analysis using UPGMA algorithm taking Dice Similarity coefficient separated 60 accessions into 2-major and 3-minor clusters. The genetic diversity analysis revealed the highest for Terai and the lowest for High-hill zone. Cluster I comprised of accessions from High-hill and Mid-hill regions revealing the close genetic relationship, whereas cluster II comprised of accessions from all three agro-ecological zones and the exotic varieties. Furthermore, our results revealed the accessions harvested from different geographical gradients were not genetically distinct, but highest diversity was observed in Terai accessions in comparison to the regions belonging to the High and Mid-hills. Thus, our data indicate that the ISSR provides a better option for evaluating the genetic diversity of Nepalese Acid Lime cultivars and furnished significant information, assisting parental selection in current and future breeding programs and germplasm conservation which ultimately may help to provide a technological breakthrough for the farmers of the developing country like Nepal.

Preprint ARTICLE | doi:10.20944/preprints202410.0961.v1

Investigating Genetic Diversity and Correlations Between Mineral Concentration and Neurotoxin (β-ODAP) Content in the Lathyrus Genus

Fadoua Abdallah, Zakaria Kehel, Mohamed Amine El Kalchi, Ahmed Amri, Adil el Baouchi, Zine El Abidine Triqui, Moez Amri, Shiv Kumar

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Lathyrus spp.; grass pea; ODAP content; neurotoxins; mineral concentration; wild crop relatives; genetic variability; correlation

Online: 12 October 2024 (08:12:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0120.v1

Molecular Diversity of The Tidal Swamp Rice (Oryza sativa L.) Germplasm of The South Kalimantan, Indonesia

Dindin H. Mursyidin, Purnomo Purnomo, Issirep Sumardi, Budi S. Daryono

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Oryza sativa; genetic diversity; tidal swamp; breeding and conservation programs

Online: 15 March 2018 (06:50:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.0642.v1

The Genus Chaetogaster Baer, 1827 (Annelida, Clitellata) in Switzerland: A First Step towards Cataloguing Its Molecular Diversity, and Description of New Species on a DNA Sequence Basis

Régis Vivien, Michel Lafont, Colin Issartel, Benoît J.D. Ferrari, Patrick Martin

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: aquatic oligochaetes; Chaetogaster; cryptic diversity; molecular systematics; genetic lineages; new species

Online: 9 August 2024 (07:10:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0711.v1

Unlocking glioblastoma vulnerabilities with CRISPR-based genetic screening

Yitong Fang, Xing Li, Ruilin Tian

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: glioblastoma; CRISPR-based genetic screening; therapy resistance; genetic determinants; therapeutic targets

Online: 10 April 2024 (08:14:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0249.v1

The Yeast Atlas of Appalachia: Species and Phenotypic Diversity of Herbicide Resistance in Wild Yeast

Jordan B. Barney, Matthew J. Winans, Catherine B. Blackwood, Amaruy Pupo, Jennifer E. G. Gallagher

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Fungal diversity; Saccharomyces; genetic diversity; glyphosate-based herbicides; copper-based fungicides; RoundUp Ready™ corn; phylogenetics

Online: 17 February 2020 (15:37:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202003.0463.v1

The Impact of the Colonization of the Invasive American Artemia franciscana (Crustacea: Anostraca) on Genetic Differentiation in the United Arab Emirates (Asia)

Alireza Asem, Rolf Schuster, Amin Eimanifar, Hao Lu, Muhan Li, Chunwei Liu, Pei-Zheng Wang, Weidong Li

Subject: Social Sciences, Ethnic And Cultural Studies Keywords: Artemia franciscana; non-native population; mtDNA-COI; genetic variation; biodiversity; UAE

Online: 31 March 2020 (22:38:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0103.v1

Microsatellite Sequence Polymorphisms Reveals Substantial Diversity in Caribbean Breadfruit [Artocarpus altilis (Parkinson) Fosberg] Germplasm

Oral O Daley, Angela T Alleyne, Laura B Roberts-Nkrumah, Lambert A Motilal

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Crop germplasm; genetic diversity; nucleotide diversity; nucleotide polymorphism; SSR markers; un-derutilized crop

Online: 2 February 2024 (04:54:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0381.v1

Diversity and Safety Aspects of Coagulase Negative Staphylococci in Ventricina Del Vastese Italian Dry Fermented Sausage

Carmela Amadoro, Franca Rossi, Palmiro Poltronieri, Lucio Marino, Giampaolo Colavita

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: fermented sausage; Ventricina del Vastese; traditional production; coagulase negative staphylo-cocci; hazardous genetic traits; antibiotic resistance

Online: 21 November 2022 (07:31:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.1471.v1

Diversity and Evolution of the MHC Class II DRB Gene in an Alpine Ungulate, the Siberian Ibex (Capra sibirica), Experienced a Demographic Fluctuation in China

Pei-Pei Dong, Rui-Rui Wang, Shamshidin Abduriyim

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Mountain ungulate; MHC DRB gene; genetic diversity; population fluctuation

Online: 21 July 2023 (09:13:12 CEST)

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The major histocompatibility complex (MHC) genes are the most polymorphic genes in vertebrates, and their proteins play a critical role in adaptive immunity for defense against a variety of pathogens. MHC diversity was lost in many species after experiencing a decline in size. To understand the variation and evolution of MHC genes in the Siberian ibex, Capra sibirica, which has undergone a population decline, we analyzed the variation of the second exon of MHC class II DRB genes in samples collected from five geographic localities in Xinjiang, China, that belong to three diverged mitochondrial clades. Consequently, we identified a total of 26 putative functional alleles (PFAs) with 260 bp in length from 43 individuals, and found one (for 27 individuals) to three (for 5 individuals) PFAs per individual, indicating the presence of one or two DRB loci per haploid genome. The Casi-DRB1*16 was the most frequently occurring PFA, Casi-DRB1*22 came after found in only seven individuals, 14 PFAs occurred once (7 PFAs twice), implying high frequency of rare PFAs. Interestingly, more than half of the (15) PFAs were specific to clade I, only one and three PFAs were specific to clades II and III, respectively. So, we assume that the polygamy and sextual segregation nature of this species likely contributed to the allelic diversity of DRB genes. Genetic diversity indices showed that PFAs of clade II were lower in nucleotide, amino acid, and supertype diversity compared to those of the other two clades. The way of allele sharing and FST values between three clades were to some extent in agreement with pattern observed in mitochondrial DNA divergence. In addition, recombination analyses revealed no evidence for significant signatures of recombination events. Alleles shared by clades III and the other two clades diverged 6 million years ago, and systematic neighbor grids showed cross-species polymorphisms. Together with the PAML and MEME analyses, the results indicated that the DRB gene in C. sibirica evolved under balancing and positive selection. However, by comparison, it can be clearly seen that different populations were under different selective pressures. Our results are valuable in understanding the diversity and evolution of the DRB gene in a mountain living C. sibirica and in making decisions on future long-term protection strategies.

Preprint ARTICLE | doi:10.20944/preprints202312.0606.v1

Estimation of Genetic Diversity and Number of Unique Multilocus Genotypes (MLGs) of Cassava Germplasm from Burkina Faso Using Simple Sequence Repeat (SSR) Markers

Monique SORO, Serge Marie Felicien Wend-Pagnagdé Zida, Koussao Somé, Fidèle Tiendrébéogo, Daniel H. Otron, Justin S. Pita, James B. Néya, Daouda Koné

Subject: Biology And Life Sciences, Plant Sciences Keywords: cassava, genotypes, genetic diversity, SSRs markers, population structure, Unique multilocus genotypes

Online: 8 December 2023 (13:08:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1144.v1

Linking Wetland Ecosystem Services to Fish Genetic Resources with Special Reference to Hilsa Shad (Tenualosa ilisha): A Novel Study from Northeastern Bangladesh

Atiqur Rahman Sunny, Md. Arifur Rahman, Md. Nazmul Hasan, Jeba Faizah Rahman, Sharif Ahmed Sazzad, Md. Faruque Miah, Md. Ashrafuzzaman, Shamsul Haque Prodhan

Subject: Biology And Life Sciences, Aquatic Science Keywords: Wetland; Ecosystem services; Genetic diversity; Hilsa; Bangladesh

Online: 20 February 2024 (12:44:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.1705.v1

MixDeR: A SNP Mixture Deconvolution Workflow for Forensic Genetic Genealogy

Rebecca Mitchell, Michelle Peck, Erin Gorden, Rebecca Just

Subject: Biology And Life Sciences, Other Keywords: mixtures; SNPs; forensic genetic genealogy (FGG); investigative genetic genealogy (IGG); Kintelligence; software

Online: 24 July 2024 (14:45:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2528.v1

Development and Application of Microsatellite Markers for Genetic Diversity Assessment and Construction of a Core Collection of Myrciaria dubia Germplasm from the Peruvian Amazon

Juan C. Castro, Stalin J. Vasquez-Guizado, Bianca E. Vigil, Francisco Ascue, Naysha Rojas-Villa, Jae D. Paredes, Marianela Cobos, Carlos G. Castro, Daniel E. Motta, Pedro M. Adrianzen, Sixto A. Imán, J. Dylan Maddox

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Amazonian crop; ex situ conservation; core collection; molecular markers; plant genetic resources; simple sequence repeats

Online: 31 July 2024 (10:22:45 CEST)

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The Amazonian shrub Myrciaria dubia (Kunth) McVaugh, known as "camu-camu", produces vitamin C-rich fruits of growing commercial interest. However, sustainable utilization requires assessment and protection of the genetic diversity of the available germplasm. We hypothesized that the ex situ M. dubia germplasm bank assembled from eight river basins across the Peruvian Amazon would harbor substantial genetic diversity and have a genetic population structure. This study aimed to (1) develop new polymorphic microsatellite markers, (2) characterize genetic diversity and validate the hypothesis in the ex situ germplasm, and (3) construct a core subset representing maximum allelic variability. Sixteen polymorphic microsatellite loci were developed using an enrichment approach. The evaluation of 336 genotypes from 43 accessions originating from eight river basins of the germplasm bank corroborated this hypothesis, revealing high gene diversity, with observed heterozygosity ranging from 0.468 to 0.644 and expected heterozygosity from 0.684 to 0.817 at the river basin level. Analysis of molecular variance showed a higher genetic variation within accessions and river basins, at 73% and 86%, respectively, than among accessions and river basins, at 27% and 14 %, respectively. Bayesian clustering detected the presence of ten genetic clusters, with several degrees of admixture among river basins. The Putumayo River basin showed a clear genetic homogeneity. A core collection of 84 genotypes was constructed, thus covering 86.7% of the global allelic diversity. These results have important implications for M. dubia conservation strategies and breeding programs, in demonstrating a need for genetic connectivity between populations but preserving unique genetic resources in isolated basins. These results validate the expected levels of diversity and population subdivision in a crop and stress the need to secure genetically diverse germplasms, underscoring the importance of thorough genetic characterization for ex situ germplasm management.

Preprint ARTICLE | doi:10.20944/preprints202305.2257.v1

Genetic Diversity and Population Structure of Bursaphelenchus xylophilus in Central China based on SNP Markers

Aixia Yang, Xiaolei Ding, Yuan Feng, Tingting Chen, Jianren Ye

Subject: Biology And Life Sciences, Forestry Keywords: Bursaphelenchus xylophilus; SNP; genetic diversity; population differentiation (List three to ten pertinent keywords specific to the article yet reasonably common within the subject discipline.)

Online: 31 May 2023 (13:23:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.2221.v1

Human-Activity-Mediated Gene Flows Are Involved in the Establishment of Magnaporthe oryzae Population Structures: A Population Genomic Analysis

Guohua Duan, Yuchan Liu, Cheng Zheng, Kaihui Yu, Jiahui Xie, Baohua Wang, Huakun Zheng, Wei Tang, Jiandong Bao, Zonghua Wang, Meilian Chen

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Magnaporthe oryzae; population structure; genetic diversity; gene flow

Online: 30 August 2024 (08:36:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0205.v1

Genetic Characterization of Some Accessions of Barley in Algeria with Microsatellites (SSR) Markers

Warda Taibi, Fatima Henkrar, Sripada Mahabala Udupa, Suheil bechir semir Gaouar

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Genetic diversity; SSR markers; barley; Algeria

Online: 2 July 2024 (14:49:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1677.v1

Global Genetic Algorithm for Automating and Optimizing Petroleum Well Deployment in Complex Reservoirs

Sonny Irawan, Dennis Delali Kwesi Wayo, Alfrendo Satyanaga, Jong Kim

Subject: Engineering, Chemical Engineering Keywords: Well deployment; Genetic Algorithms; CMG; Global Optimization; Reservoir

Online: 29 February 2024 (11:41:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202003.0098.v1

Using ISSR Genomic Fingerprinting to Study the Genetic Differentiation of Artemia Leach, 1819 (Crustacea: Anostraca) from Iran and Neighbor Regions with the Focus on the Invasive American Artemia franciscana

Amin Eimanifar, Alireza Asem, Pei-Zheng Wang, Weidong Li, Michael Wink

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: genetic variation; brine shrimp Artemia; invasive species; mt-DNA COI; Inter-Simple Sequence Repeats (ISSRs) genomic fingerprinting; Western Asia

Online: 6 March 2020 (02:43:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.2452.v1

Heterozygous Smad4 Knock out Effect on Pancreatic and Body Weight Variation in F1 Population Using Mutant and Wild Type Collaborative Cross Mice

Osayd Zohud, Iqbal M. Lone, Kareem Midlej, Aysar Nashef, Imad Abu-Elnaaj, Fuad A. Iraqi

Subject: Biology And Life Sciences, Other Keywords: Smad4; pancreatic weight; genetic background; sex differences; Collaborative Cross; F1 mice; genetic modifiers; tumor suppressor gene

Online: 30 July 2024 (10:53:56 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202404.0158.v1

Molecular Detection and Characterization of Mycoviruses in the Genus Armillaria in the Czech Republic

Lucie Walterová, Leticia Botella, Ondřej Hejna, Marcos De La Pena, Tomáš Tonka, Vladislav Čurn

Subject: Biology And Life Sciences, Virology Keywords: Root rot, viruses; circular genetic elements; ambivirus; tymovirus; biological control

Online: 2 April 2024 (05:38:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1531.v1

Pregnancy Planning and Genetic Testing: Exploring Advantages, and Challenges

Ulf Kristoffersson, Maria Johansson-Soller

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: Pregnancy planning and genetic testing; preconception genetic testing; genetic disorders; reproductive healthcare; genetic counselling; ethical and societal considerations

Online: 18 July 2024 (16:48:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0077.v1

Enhancing Sustainable Construction: Optimization Tool for Glulam Roof Structures according to Eurocode 5

María Simón-Portela, José Ramón Villar-García, Pablo Vidal-López, Desirée Rodríguez-Robles

Subject: Engineering, Architecture, Building And Construction Keywords: artificial intelligence; genetic algorithm; timber; roof structure; Eurocode 5

Online: 1 April 2024 (17:18:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0824.v1

Depicting of DNA Makeup of Spring Bread Wheat Genotypes Using SSR Markers and Their Association with Heat Tolerance

Md. Forhad Amin, Mohammad Nur Alam, Golam Faruq, Md. Mustafa Khan, Md. Mahbubur Rahman

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Bread wheat; Fingerprinting; Genetic diversity; Heat tolerance; SSR marker

Online: 11 September 2024 (10:39:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0524.v1

Precision Dopaminergic Treatment in a Cohort of Parkinson’s disease Patients Carrying Autosomal Recessive Gene Variants: Clinical Cohort Data and a Mini Review

Christos Koros, Athina-Maria Simitsi, Nikolaos Papagiannakis, ANASTASIA BOUGEA, Roubina Antonelou, Ioanna Pachi, Evangelos Sfikas, Evangelia Stanitsa, Efthalia Angelopoulou, Vasilios C. Constantinides, Sokratis Papageorgiou, Constantin Potagas, Maria Stamelou, Leonidas Stefanis

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Parkinson’s disease; genetic; recessive; treatment; Levodopa; dopamine agonists; amantadine

Online: 9 May 2024 (14:43:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0236.v1

Characterization of Cassava (Manihot esculenta) Germplasm from Sierra Leone Based on Agro-Morphological and Culinary Traits

Vandi Amara, Alusaine Edward Samura, Prince Emmanuel Norman, Sheku Alfred Kanu, Kumba Yannah Karim, Fidele Tiendrebeogo, Angela Obiageli Eni, Justin S Pita

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Cassava; Germplasm; Genetic variability; Morpho-culinary markers; phenotypic relationship

Online: 6 May 2024 (07:12:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0966.v1

Genetic Variability and Interrelationships of Grain Quality, Cooking Quality and Nutritional Quality Traits in Cowpea: Implication for Cowpea Improvement

Michael M. Chipeta, Esnart Yohane, Jessica Kampanje-Phiri, John Kafwambira

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Consumer-preferred traits; cowpea, genetic variability; interrelationships; quality traits

Online: 19 February 2024 (03:32:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.2089.v1

Exploring the Impact of IL-33 Gene Polymorphism (rs1929992) on Susceptibility to Chronic Urticaria and its Association with Serum Interleukin-33 levels

Carmen-Teodora Dobrican-Băruța, Diana Mihaela Deleanu, Mihaela Iancu, Ioana Adriana Muntean, Irena Nedelea, Radu-Gheorghe Bălan, Lucia Maria Procopciuc, Gabriela Adriana Filip

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: chronic urticaria; genetic polymorphisms; IL-33; SNP rs1929992; cytokine; autoimmune; susceptibility

Online: 26 September 2024 (17:07:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.1641.v1

Probiotic yeasts: a developing reality?

Vivian Tullio

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Yeast probiotics; Promising benefit; Probiotic development; Genetic engineering

Online: 24 May 2024 (11:18:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0060.v1

Structural Optimization in Building Information Modeling (BIM) Projects Using Visual Programming, Evolutionary Algorithms, and Sustainability Assessment Tools

Feyzullah Yavan, Reza Maalek, Vedat Toğan

Subject: Engineering, Architecture, Building And Construction Keywords: Structural Optimization; Genetic Algorithm; Parametric Design; Visual Programming; Generative Modeling

Online: 2 April 2024 (12:41:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0182.v1

Hybrid Genetic Algorithm and Tabu Search for Solving Preventive Maintenance Scheduling Problem for Cogeneration Plants

Khaled Alhamad, Yousif Alkhezi

Subject: Computer Science And Mathematics, Discrete Mathematics And Combinatorics Keywords: preventive maintenance; scheduling; optimization; genetic algorithm; tabu search; metaheuristic

Online: 2 April 2024 (12:56:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.2564.v1

The Genetic Analysis and Clinical Therapy in Lung Cancer: Current Advances and Future Directions

Angela Rina, Debora Maffeo, Francesca Minnai, Martina Esposito, Maria Palmieri, Viola Bianca Serio, Diletta Rosati, Francesca Mari, Elisa Frullanti, Francesca Colombo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: lung cancer; genetic discoveries; target therapy; personalized treatments

Online: 31 July 2024 (14:29:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201607.0015.v1

Design and analysis of the redundancy allocation problem using a greedy technique

Souradeep Nanda, SIDDHARTH SHARMA, Kundnani Piyush, ANAND SHANKER DEB, C. Vijayalakshmi

Subject: Computer Science And Mathematics, Data Structures, Algorithms And Complexity Keywords: Redundancy Allocation Problem, Genetic Algorithm, Simulated Annealing, Greedy Algorithm

Online: 9 July 2016 (05:13:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.2413.v1

An Expanded Molecular and Systems Toolbox for Imaging, Mapping, and Controlling Local Translation

Warunya Onchan, Chadaporn Attakitbancha, Chayasith Uttamapinant

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: local translation; translatome; ribosome; genetic code expansion; imaging

Online: 30 July 2024 (11:03:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1548.v1

Unravelling the Genetic Architecture of Serum Biochemical Indicators in Sheep

Mehmet Kizilaslan, Yunus Arzik, Sedat Behrem, Esra Yavuz, Stephen N. White, Mehmet Ulas Cinar

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Serum biochemical indicators, Ovis aries, GWAS, QTL, genetic correlation, heritability

Online: 21 June 2024 (16:51:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1357.v1

Revisiting Classical Controllers Design and Tuning with Genetic Programming

Carlos A. García, Manel Velasco, Cecilio Angulo, Pau Marti, Antonio Camacho

Subject: Engineering, Control And Systems Engineering Keywords: genetic algorithm; genetic programming; control design; control tuning

Online: 22 November 2023 (07:49:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202410.2607.v1

From Single-Cell RNA Sequencing to Functional Networks: Understanding Genetic Variants in Cancer Through Perturb-seq

Jesús Chinchilla Caravaca

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Single-cell RNA sequencing (scRNA-seq); functional networks; genetic variants in cancer; Perturbseq; cancer genomics; KRAS; TP53; gene expression profiling; genetic perturbation

Online: 1 November 2024 (08:09:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1825.v1

Genetic Heterogeneity Correlated with Phenotypic Variability in Congenital Hyperinsulinism Caused by Mutation in ABCC8 Gene Associated with Early‐Onset Persistent Neonatal Hypoglycemia

Lăcrămioara Ionela Butnariu, Delia Andreia Bizim, Gabriela Păduraru, Luminița Păduraru, Ștefana Maria Moisă, Setalia Popa, Nicoleta Gimiga, Gabriela Ghiga, Minerva Codruța Bădescu, Ancuta Lupu, Ioana Vasiliu, Laura Mihaela Trandafir

Subject: Medicine And Pharmacology, Other Keywords: hyperinsulinemic hypoglycemia; ABCC8 gene; mutation; ATP- sensitive potassium channel; genetic heterogeneity; phenotypic variability

Online: 29 March 2024 (08:08:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.0329.v1

Strategies for Breeding Programs to Reduce Post-harvest Water Loss in Fresh Market Peppers

Rego ER, Finger FL, Pessoa AMS, Silva Anderson Rodrigo da, Azevedo AA, Meira RMSA, da Silva ALBR, Silva RS, Rêgo MM

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: shelf life; genetic effects; diallel; narrow sense heritability

Online: 7 May 2024 (08:17:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0719.v1

Exploring the Rise in Precocious Puberty: Interplay of Genetic and Environmental Factors

Jhancy Malay, Biji Thomas George, Rajani Dube, Subhranshu Sekhar Kar, Imran Rashid Rangraze

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: precocious puberty; genetic factors; endocrinal factors; environmental factors

Online: 12 August 2024 (03:55:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.1841.v1

The Biological and Genetic Mechanisms of Yield Self-Regulation in Apple Tree (Malus × domestica Borkh.)

Aurelijus Starkus, Šarūnė Morkūnaitė-Haimi, Tautvydas Gurskas, Edvinas Misiukevičius, Vidmantas Stanys, Birutė Frercks

Subject: Biology And Life Sciences, Horticulture Keywords: Malus × domestica; abscission; fruit - drop; yield self- regulation; phytohormones; genetic mecha-nisms

Online: 26 August 2024 (11:49:46 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202403.0950.v2

SSR Markers-Based DNA Fingerprinting for Varietal Identification in Mango Cultivars

Muhammad Aleem Ashraf, Javed Iqbal, Imran Shahid, Muhammad Kashif, Yufeng Li, Yu Kong, Naitong Yu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Mango tree; SSR markers; mango varieties; genetic diversity; cultivar identification diagram, loci, polymorphism; genetic resources in Pakistan; breeding; cultivar development

Online: 17 June 2024 (08:04:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1055.v1

Identification and Transformation of a New Powdery Mildew Resistance Gene PmCAHM From Landrace Changanhongmai Into Common Wheat

Xueyan Chen, Yongfu Wang, Guohao Han, Jianzhong Fa, Qingqing Tan, Guoxia Liu, Hong Zhang, Yajuan Wang

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: common wheat; powdery mildew; molecular marker; genetic population

Online: 20 February 2024 (04:32:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1003.v1

Ending an Odyssey? The Psychosocial Experiences of Parents after the Genetic Diagnosis of a Mitochondrial Disease in Children

Oliver Heath, Emma Hammerl, Anna Spitzinger, Saskia B. Wortmann

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Mitochondrial diseases; genetic diagnosis; value of a diagnosis; diagnostic odyssey; parental attitudes

Online: 16 April 2024 (03:41:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0968.v1

Genetic Evaluation of Monthly Test Day Milk Yields of Jersey Crossbred Cattle under Farmers’ Production System in Tamil Nadu, India

D. Kasiviswanathan, P. Devendran, R. Venkataramanan, S. Meenakshi Sundaram, G. Senthil Kumar, Sunday. O. Peters

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Jersey crossbred cattle; Genetic correlation; Heritability; Random regression; REML; Test day milk yield

Online: 14 August 2024 (00:38:20 CEST)

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Tamil Nadu, a state in southern India, is bereft of any native milch or dual-purpose cattle breed and the state depends chiefly on crossbred cattle for milk production. As most (90 percent) of the milk production in the state was contributed by Jersey crossbred cattle, the genetic evaluation study was intended to assess the milk production traits viz., test-day milk yields (TDMYs), total milk yield (TMY) and 305-day milk yield (305MY) in these crossbred cattle reared under farmers’ rearing environment. Data on monthly TDMYs (TDMY1 to TDMY10) of Jersey crossbred cows (n=81,653) reared by the farmers over 24 years (1999-2022) were collected for evaluation. The influence of non-genetic factors viz., location (agroclimatic zones), period and season of calving, and parity on TDMYs, TMY, and 305MY were assessed, and the variance and covariance components for genetic parameters (heritability and genetic correlation) of the traits were estimated by the method of restricted maximum likelihood (REML) under multivariate animal model and by random regression model (RRM). The overall means of various TDMYs ranged from 4.98 (TDMY10) to 9.95 kg (TDMY2) and, for TMY and 305MY the means were 2480.33 and 2393.71 kg respectively. The heritabilities estimated by animal model for TDMYs were high and ranged from 0.39 ± 0.01 to 0.47 ± 0.01 and were fairly less variable throughout the lactation while the estimates obtained by RRM were medium to high and ranged between 0.28 ± 0.01 and 0.65 ± 0.02 for different days in milk (DIMs). The heritability estimated for TMY and 305MY were 0.48 ± 0.01 and 0.49 ± 0.01 respectively. The estimates of heritability in mid-lactation yields were comparatively little less than those at the beginning and the end of lactation. The high estimates of heritabilities for TDMYs, TMY, and 305MY obtained in the present study offered an ample scope for improving milk production through selective breeding. Genetic correlations between TDMYs estimated by animal model were positive and moderate to high, with a range between 0.47 ± 0.01 and 0.99 ± 0.00. Considerably higher estimates (0.97-0.99) were observed between adjacent TDMYs showing strong genetic associations. By RRM, genetic correlations estimated between DIMs were positive, except for a few estimates and the magnitude of genetic correlation decreased with an increase in the interval between the DIMs. The high genetic correlation observed between the TDMYs in early and mid stages of lactation with TMY and 305MY suggested that these test day yields could be used favorably for the early selection of cows for milk production which facilitates reduction in the generation interval and consequently increase the annual genetic gain for the milk production traits.

Preprint CASE REPORT | doi:10.20944/preprints202406.1988.v1

Infantile Neuroaxonal Dystrophy: A Case Report and Review of Literature

Alian Fatima, Shahd A. Abuhijleh, Abdul Fatah, Mariam M. Mohsin, Subhranshu Sekhar Kar, Rajani Dube, Biji Thomas George, Manjunatha Goud Bellary Kuruba

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Neurodegenerative disorder; Infantile Neuroaxonal Dystrophy; developmental regression; global developmental delay; genetic counseling

Online: 28 June 2024 (02:44:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1083.v1

Prevalence of Genetic Variants and Deep Phenotyping of Patients with Thoracic Aortic Aneurysm and Dissection: A Cross-Sectional Single Centre Cohort Study

Adrian Mahlmann, Nesma Elzanaty, Mai Saleh, Marc Irqsusi, Ardawan Rastan, Jennifer Lynne Leip, Christian-Alexander Behrendt, Tamer Ghazy

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: thoracic aortic disease; phenotype; genetic mutation; genetic variant; aneurysm; dissection

Online: 14 December 2023 (12:14:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.2074.v1

Discrete Modeling of Projectile Penetration into Calcareous Sand Subgrade Runway Pavement Structure and Genetic Algorithm Optimization for Critical Striking Velocity

Chucai Peng, Jingnan Huang, Xichen Sun, Yifei Nan, Yaohui Chen, Kun Chen, Jun Feng

Subject: Engineering, Mechanical Engineering Keywords: runway pavement structure; discrete element method; depth of penetration; genetic algorithm; critical striking velocity

Online: 26 September 2024 (09:10:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2039.v1

Germline Variants in Proto-Oncogenes and Tumor Suppressor Genes in Women with Cervical Cancer

Ksenia Lenkova, Rita Khusainova, Raushaniya Minyazeva, Aliya Zaripova, Irina Gilyazova, Natalia Mokrysheva, Ildar Minniakhmetov

Subject: Biology And Life Sciences, Life Sciences Keywords: cancer; oncogenes; tumor suppressor genes; molecular genetic landscape

Online: 25 September 2024 (15:33:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.1883.v1

A Novel Optimization Method via Box-Behnken Design Integrated with Back Propagation Neural Network – Genetic Algorithm on Hydrogen Purification

Nannan Zhang, Sumeng Hu, Qianqian Xin

Subject: Engineering, Energy And Fuel Technology Keywords: optimization; back propagation neural network; Box-Behnken design; genetic algorithm; hydrogen purification

Online: 24 October 2024 (10:27:04 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202401.1175.v1

The Importance of Offering Exome or Genome Sequencing in Adult Neuromuscular Clinics

Laynie Dratch, Tanya M Bardakjian, Kelsey Johnson, Nareen Babaian, Pedro Gonzalez-Alegre, Lauren Elman, Colin Quinn, Michael H Guo, Steven S Scherer, Defne A Amado

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Neurogenetics; genetic testing; genetic counseling; neuromuscular

Online: 16 January 2024 (06:25:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.2213.v1

Enhanced Carbon-Oxygen Ratio Logging Interpretation Methods and Applications in Offshore OilFields

Wei Zhou, Yaoting Lin, Gang Gao, Peng Wang

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: carbon-oxygen ratio logging; fan chart method; ratio chart method; improved genetic algorithm

Online: 29 September 2024 (03:22:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1538.v2

Is the Myasthenia Gravis (MG) the Result of Age and Sex/Gender? A Narrative Review for Identifying Genetic and Epigenetic Biomarkers for a Differential MG Management in Old and Young Women

Giuseppe Schirò, Tiziana Colletti, tommaso piccoli, paolo ragonese, giuseppe salemi, Carmela Rita Balistreri, marco d'amelio

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Myasthenia gravis (MG); age and sex/gender; two different forms; genetic and epigenetic factors

Online: 30 April 2024 (11:46:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0637.v1

Enhanced Microgrid Control through Genetic Predictive Control: Integrating Genetic Algorithms with Model Predictive Control for Improved Non-Linearity and Non-Convexity Handling

Muhammed Cavus, Adib Allahham

Subject: Engineering, Electrical And Electronic Engineering Keywords: Genetic Algorithms (GA); Genetic Predictive Control (GPC); Energy management system (EMS); Microgrid (MG) control; Model Predictive Control (MPC); Non-linear systems

Online: 9 August 2024 (00:16:56 CEST)

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Microgrid (MG) control is essential for efficient, reliable, and sustainable energy management in distributed energy systems. Genetic Algorithm-based energy management systems (GA-EMS) can optimally control a MG by finding global optima and handling complex, non-linear, and non-convex problems, but they can be computationally intensive, making real-time control challenging. Model Predictive Control (MPC)-based EMS predicts future behaviour over a defined horizon, ensuring optimal performance and constraint satisfaction but typically relies on linear models. This paper proposes a novel Genetic Predictive Control (GPC) method, combining GA and MPC to enhance resource allocation, balance multiple objectives, and adapt dynamically to changing conditions. Integrating GA with MPC significantly improves the handling of non-linearities and non-convexity in the system model, leading to more accurate and effective control. Comparative analysis shows that GPC significantly reduces excess power production—surplus power generated beyond load demand—improving resource allocation efficiency. For instance, in the Mutation–Random Selection scenario, GPC reduced excess power to 76.0W compared to 87.0W with GA. Additionally, GPC balances cost, emissions, and power efficiency. In the Crossover-Elitism scenario, GPC achieved a daily cost of $113.94 compared to GA's $127.80, and carbon emissions of 52.83 kg CO2e compared to GA's 69.71 kg CO2e, demonstrating GPC's cost efficiency and environmental benefits. While MPC optimizes a weighted sum of objectives, designing appropriate weights can be challenging and may result in non-convex problems. GA handles multiple, conflicting objectives through multi-objective optimization, providing Pareto-optimal solutions. GPC's dynamic adaptability maintains optimal performance by forecasting future load demands and adjusting control actions. GPC consistently achieves lower emissions than GA across various scenarios and, although it sometimes incurs higher costs, such as $113.94 compared to $131.90 in the Crossover–Random Selection scenario, its holistic approach balances these costs with other metrics, making it cost-effective in the long run. By reducing excess power production and emissions, GPC contributes to economic savings and promotes sustainable practices. These findings underscore GPC's potential as a versatile, efficient, and environmentally beneficial optimization tool for power generation systems.

Preprint REVIEW | doi:10.20944/preprints202012.0738.v1

Utility of Whole-Exome Sequencing in Pediatric and Medical Diagnosis

Mohd Fareed, Varun Sharma, Hemender Singh

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Next generation sequencing; Genetic disorders; Genomic medicine; Genetic counseling; Rare diseases

Online: 29 December 2020 (16:47:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.0476.v1

Public Service Provisions for Land Resource Planning in Khao Phanom, Krabi Province in Thailand

Teeraphat Kitjarak, Shubham Pathak, Xinlin Qi, Thussaneeya Boripis

Subject: Social Sciences, Government Keywords: Land resource planning; Plant genetic resources; Policy implementation; Public service; Thailand 4.0

Online: 6 July 2024 (04:50:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1387.v1

Study on the Design of a New Three-Dimensional Seismic Isolation Bearing Based on Improved Genetic Algorithm for Bridge Engineering

Ying Sheng, Zhenchao Yang, Yu Meng, Bin Jia

Subject: Engineering, Civil Engineering Keywords: three-dimensional seismic isolation bearing; bridge engineering; sensitivity of the design parameters; improved genetic algorithm; good seismic isolation effect

Online: 18 September 2024 (11:12:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0474.v1

Enhancing Vehicle Lightweight Design Process with Genetic Algorithm-Optimized BP Neural Network and Topology Optimization: A Comprehensive Study

Shengzhao Liao, Li Zhong, Liu Yi

Subject: Engineering, Mechanical Engineering Keywords: lightweight design of vehicle technology; genetic algorithm; BP neural network; topology optimization; design parameter optimization

Online: 8 February 2024 (07:16:52 CET)

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Amid the swift progression of the global automobile industry, the aspiration for lightweight vehicle design has surfaced as a crucial approach to boost fuel efficiency and curtail environmental impact. The objective of this study revolves around achieving holistic optimization of vehicle structure via detailed scrutiny of vehicle process characteristics, amalgamated with a Back Propagation neural network (BPNN) optimized by a genetic algorithm (GA) and a topology optimization (TO) method.The process initiates with an examination of the vehicle's technical characteristics, succeeded by an optimization protocol that couples GA with BPNN. This exhaustive optimization procedure derives the best-fit values of design parameters and identifies the globally optimal lightweight design approach. Subsequently, a comprehensive structural optimization is actualized by modifying the topological distribution of the structure.A simulation experiment of the conceptual car body beam skeleton is conducted as a conclusive step, and the anti-collision capacity of the car body beam skeleton is assessed by measuring deformation intrusion. The findings reveal that in the vehicle topology optimization, a comparative analysis of pre and post-optimization results indicates an improved topological density across diverse sections. The topological density of the vehicle's frontal structure escalates from 0.75 to 0.8. Following optimization, the stiffness assessment records a marginal increase (within the range of 0.02–0.05), implying that the lightweight design does not compromise the general rigidity of the structure.The optimized body structure manifests superior crashworthiness in the crash test: the deformation intrusion diminishes by 27% in front-end collisions. In side impacts, the deformation and intrusion at critical points are reduced by 13.15% to 10% respectively. The comprehensive method proposed herein proves to be an efficient strategy to actualize the lightweight design of vehicles.

Preprint ARTICLE | doi:10.20944/preprints202408.0698.v1

A Method for Optimizing Production Layers Regroup Based on Genetic Algorithm

Lining Cui, Jiqun Zhang, Dehai He, Longchuan Pu, Boyang Peng, Xiaolin Ping

Subject: Engineering, Energy And Fuel Technology Keywords: high-water-cut reservoirs; production layer regroup; genetic algorithm; EOR

Online: 9 August 2024 (09:44:38 CEST)

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