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Preprint ARTICLE | doi:10.20944/preprints202307.0134.v1

Modeling and Visualizing the Dynamics of Epidemic Diseases Spread. The Case of COVID-19

Loukas Zachilas, Christos Benos

Subject: Physical Sciences, Biophysics Keywords: COVID-19; SARS-CoV-2; epidemiology; lattice simulation; infection diffusion; epidemics; control measures

Online: 4 July 2023 (03:58:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0530.v1

ISIDOG Consensus Guidelines on Covid-19 Vaccination for Women before, during and after Pregnancy

Gilbert Gerard Ghislain Donders, Svitrigaile Grinceviciene, Kai Haldre, Risa Lonnee-Hofmann, Francesca Donders, Aristotelis Tsiakalos, Albert Adriaanse, Jose Martinez de Oliveira, Kevin Ault, Werner Mendling

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: vaccine, pregnancy complication, SARS-CoV-2, COVID-19, maternal complications, pandemic, prevention, safety

Online: 20 April 2021 (11:22:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0092.v1

Relationships between Urine Albumin Excretion and Dietary Habits in Patients with Type 2 Diabetes

Sadako Matsui, Yasuhisa Someya, Hiroshi Yoshida

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Type 2 diabetes; urea albumin excretion; food frequency questionnaire survey; β-cryptoxanthin; fruits

Online: 8 July 2019 (14:44:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0789.v1

Molecular Identification and Prevalence of the Mite Carpoglyphus lactis (Acarina: Carpoglyphidae) in Apis mellifera in the Republic of Korea

Thi-Thu Nguyen, Mi-Sun Yoo, Hyang-Sim Lee, So Youn Youn, Se-Ji Lee, Su-Kyoung Seo, Jaemyung Kim, Yun Sang Cho

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Apis mellifera; Carpoglyphus lactis; Cytochrome c oxidase subunit 1 (COI) gene; Molecular identification; Republic of Korea

Online: 13 March 2024 (16:10:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0158.v2

Mapping the Accessory Proteins (Orfs) of Severe Acute Respiratory Syndrome Coronavirus 2

Sunil Thomas

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: severe acute respiratory syndrome coronavirus 2; SARS-CoV-2; COVID-19; accessory protein; mapping; structure; Open reading frame, Orf.

Online: 3 November 2022 (10:27:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202208.0110.v1

Cytoprotective Activity of Newly Synthesized 3-(arylmethyl)-6-methyl-4-phenylpyridin-2(1H)-ones derivatives

Shynggys Sergazy, Zarina Shulgau, Aigerim Zhulikeyeva, Yerlan Ramankulov, Irina V. Palamarchuk, Ivan V. Kulakov

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: 3-aminopyridin-2(1H)-one derivatives; 3-(arylmethyl)-6-methyl-4-phenylpyridin-2(1H)-ones; antiradical activity; cytoprotective activity

Online: 4 August 2022 (14:12:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0161.v1

The Small Intestine, an Underestimated Site of SARS-CoV-2 Infection: From Red Queen Effect to Probiotics

Zhijie Feng, Yan Wang, Wei Qi

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: coronaviruses receptors; angiotensin-converting enzyme 2 (ACE2); COVID-19; SARS-Cov-2; the Red Queen hypothesis; segmented filamentous bacteria

Online: 10 March 2020 (08:45:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0203.v1

Molecular Cloning and Expression Analysis of COX II from Sitophilus zeamais, a Potential Action Site of AITC

Changliang Hou, Jingbo Wang, Hua Wu, Jiayu Liu, Zhiqing Ma, Juntao Feng, Xing Zhang

Subject: Biology And Life Sciences, Insect Science Keywords: Sitophilus zeamais; COXⅡ; Soluble proteins; Enzyme activity; AITC

Online: 25 August 2016 (10:11:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0130.v1

Interaction Solutions for the Fractional KdVSKR Equations in (1+1)-Dimension and (2+1)-Dimension

Lihua Zhang, Zitong Zheng, Bo Shen, Gangwei Wang, Zhenli Wang

Subject: Physical Sciences, Mathematical Physics Keywords: Korteweg-de Vries Sawada-Kotera-Ramani (KdVSKR) equation; extended Korteweg-deVries (KdV) equation; Sawada-Kotera (SK) equation; finite symmetry groups; Lie symmetry; exact solutions; consistent Riccati expansion (CRE); Hirota bilinear method; fractional derivatives

Online: 2 August 2024 (06:04:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0181.v1

Sustainable E-commerce: Blockchain and Channel Structure in Online Retail Platforms

Xunbo Wu, Wenqi Jiang, Lingjie Meng

Subject: Business, Economics And Management, Business And Management Keywords: sustainable E-commerce; blockchain technology; channel structure; online retail platform; counterfeit mitigation

Online: 2 July 2024 (05:27:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0477.v1

Epidemiological Changes in Orofacial Trauma between the Pre-Covid and COVID Periods: A Spanish Multicentre Comparative Study of Tertiary Referral Hospitals

Angela Sada-Urmeneta, Jose-Ignacio Salmeron-Escobar, Carlos Navarro-Cuéllar, Eduardo Olavarria, Gregorio Sanchez-Aniceto, Sonia Herrero-Alvarez, Oscar De la Sen-Corcuera, Anna-Maria Simon-Flores, Fernando Almeida, Iñigo Aragon-Niño, Jose-Luis Del Castillo, Dafne Gascon, Marc Agea, Manuel Tousidonis

Subject: Medicine And Pharmacology, Surgery Keywords: SARS-CoV-2; COVID-19; orofacial trauma; maxillofacial trauma; epidemiology; public health

Online: 7 June 2023 (03:35:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0709.v1

2-D Modeling to Understand the Design Configuration and Flow Dynamics of Pond-in-Pond (Pip) Wastewater Treatment System for Reuse

Kushal Adhikari, Clifford Fedler, Alireza Asadi

Subject: Engineering, Automotive Engineering Keywords: wastewater reuse; irrigation; sustainability; pond-in-pond; pond configuration; 2-D modeling

Online: 27 April 2021 (12:28:38 CEST)

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Working Paper HYPOTHESIS

Could Protein Malnutrition of Rapid Onset Explain the Atypical Symptoms of COVID-19 and Consequential Malfunctioning of the Body? A Hypothesis.

Maralyn Green

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: malnutrition; COVID-19; protein; immune system; SARS-CoV-2; cell proliferation; starvation

Online: 22 September 2020 (08:32:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0572.v1

Anti-diabetic Effects of Wild Soybean Glycine Soja Seed Extract on Type 2 Diabetic Mice and Human Hepatocytes induced Insulin Resistance

Eunjung Son, Hye Jin Choi, Seung-Hyung Kim, Dong-Gyu Jang, Jimin Cha, Jeong June Choi, Mee Ree Kim, Dong-Seon Kim

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: glycine soja seed; type 2 diabetes mellitus; antidiabetic; AMPK; Akt; PPAR-γ

Online: 26 August 2020 (09:16:38 CEST)

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Working Paper ARTICLE

Anti-Diabetic Effects of Wild Soybean Glycine Soja Seed Extract on Type 2 Diabetic Mice and Human Hepatocytes Induced Insulin Resistance

Eunjung Son, Hye Jin Choi, Seung-Hyung Kim, Dong-Gyu Jang, Jimin Cha, Jeong June Choi, Mee Ree Kim, Dong-Seon Kim

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Glycine soja seed; Type 2 diabetes mellitus; Antidiabetic; AMPK; Akt; PPAR-γ

Online: 25 August 2020 (11:47:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0102.v3

Potential of Plant Bioactive Compounds as SARS-CoV-2 Main Protease (M^pro) and Spike (S) Glycoprotein Inhibitors: A Molecular Docking Study

Trina Ekawati Tallei, Sefren Geiner Tumilaar, Nurdjannah Jane Niode, Fatimawali Fatimawali, Billy Johnson Kepel, Rinaldi Idroes, Yunus Effendi

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Medicinal plants; Mpro; 3CLpro; spike (S) glycoprotein; COVID-19; SARS-CoV-2

Online: 1 July 2020 (08:37:49 CEST)

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Since the outbreak of the COVID-19 (Coronavirus Disease 19) pandemic, researchers have been trying to investigate several active compounds found in plants that have the potential to inhibit the proliferation of SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2). The present study aimed to evaluate bioactive compounds found in plants by using a molecular docking approach to inhibit the Main Protease (M^pro) and Spike (S) glycoprotein of SARS-CoV-2. The evaluation was performed on the docking scores calculated using AutoDock Vina as a docking engine. A rule of five (RO5) was calculated to determine whether a compound meets the criteria as an active drug orally in humans. The determination of the docking score was done by selecting the best conformation of the protein-ligand complex that had the highest affinity (most negative Gibbs' free energy of binding / ΔG). As a comparison, nelfinavir (an antiretroviral drug), chloroquine and hydroxychloroquine sulfate (anti-malarial drugs recommended by the FDA as emergency drugs) were used. The results showed that hesperidin, nabiximols, pectolinarin, epigallocatechin gallate, and rhoifolin had better poses than nelfinavir, chloroquine, and hydroxychloroquine sulfate as spike glycoprotein inhibitors. Hesperidin, rhoifolin, pectolinarin, and nabiximols had about the same pose as nelfinavir, but were better than chloroquine and hydroxychloroquine sulfate as M^pro inhibitors. These plant compounds have the potential to be developed as specific therapeutic agents against COVID-19. Several natural compounds of plants evaluated in this study showed better binding free energy compared to nelfinavir, chloroquine, and hydroxychloroquine sulfate which so far are recommended in the treatment of COVID-19. As judged by the RO5 and previous study by others, the compounds kaempferol, herbacetin, eugenol, and 6-shogaol have good oral bioavailability, so they are also seen as promising candidates for the development lead compounds to treat infections caused by SARS-CoV-2.

Preprint ARTICLE | doi:10.20944/preprints202002.0139.v1

Restricticin B from the Marine Fungus Penicillium janthinellum and Its Inhibitory Activity on the NO Production in BV-2 Microglia Cells

Byeonung-Kyu Choi, Shin-Young Park, Song-Hee Jo, Dong-Kug Choi, Phan Thi Hoai Trinh, Hwa-Sun Lee, Van Anh Cao, Thi Duy Ngoc Ngo, Tran Thi Thanh Van, Hee Jae Shin

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: restricticin; marine fungus; Penicillium janthinellum; BV-2 microglia cells; anti-inflammatory; rotamer

Online: 11 February 2020 (09:28:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0124.v1

Early Lesion of Post-Primary Tuberculosis: Subclinical Driver of Disease and Target for Vaccines and Host-directed Therapies.

Robert E. E. Brown, Robert L Hunter

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: tuberculosis; secretory antigens; bronchiolar epithelium; alveolar pneumocytes; M2 polarization; COX-2, FAS; Pathogenesis; early lesion

Online: 5 November 2021 (14:50:58 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202005.0084.v1

Nsp7 and Spike Glycoprotein of SARS-CoV-2 Are Envisaged as Potential Targets of Vitamin D and Ivermectin

Jhimli Dasgupta, Udayaditya Sen, Abhisek Bakshi, Abhijit Dasgupta, Krishnendu Manna, Chinmay Saha, Rajat K. De, Satinath Mukhopadhyay, Nitai P. Bhattacharyya

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; Vitamin D; Ivermectin; RNA-dependent-RNA polymerase; Spike glycoprotein; Knowledge based docking

Online: 5 May 2020 (15:18:30 CEST)

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COVID-19 has emerged as deadly pandemic worldwide with no vaccine or suitable antiviral drugs to prevent or cure the disease. Because of the time-consuming process to develop new vaccines or antiviral agents, there has been a growing interest in repurposing some existing drugs to combat SARS-CoV-2. Vitamin D is known to be protective against acute respiratory distress syndrome (ARDS), pneumonia and cytokine storm. Recently it has been used as a repurposed drug for the treatment of H5N1 virus-induced lung injury. Circumstantial evidences indicate that people with low level of vitamin D are more susceptible to SARS-CoV-2. Although, vitamin D was suggested to interfere with viral replication, its interaction with any SARS-CoV-2 protein is unexplored yet. Beside this, ivermectin, a well-known anti-parasitic agent, exhibits potent anti-viral activities in vitro against viruses such as HIV-1 and dengue. Very recently, ivermectin has been found to reduce viral load of SARS-CoV-2 in vitro. We have analyzed available structures of SARS-CoV-2 proteins to identify probable binding partner(s) of vitamin D and ivermectin through knowledge-based docking studies and figured out possible implication of their binding in SARS-CoV-2 infection. Our observations suggest that the non-structural protein nsp7 possesses a potential site to house 25-hydroxyvitamin D3 (VDY) or the active form of Vitamin D, calcitrol. Binding of vitamin D with nsp7 likely to hamper the formation of nsp7-nsp8 complex which is required to bind with RNA dependent RNA polymerase (RdRP), nsp12 for optimal function. On the other hand, potential binding site of ivermectin has been identified in the S2 subunit of trimeric spike(S) glycoprotein of SARS-CoV-2. We propose that deeply inserted mode of ivermectin binding at three inter-subunit junctions may restrict large scale conformational changes of S2 helices which is necessary for efficient fusion of viral and host membrane. Our study, therefore, opens up avenues for further investigations to consider vitamin D and ivermectin as potential drugs against SARS-CoV-2.

Preprint ARTICLE | doi:10.20944/preprints201610.0008.v3

Properties of the long-term oscillations in the middle atmosphere based on observations from TIMED/SABER

Yiyao Zhang, Shudao Zhou, Hanqing Shi, Zheng Sheng, Weilai Shi, Huadong Du, Zhiqiang Fan

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: AO; SAO; TO; amplitude; phase

Online: 6 October 2016 (08:52:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202302.0485.v1

Eating Disorders and Dietary Supplements: A Review of the Science

Susan J Hewlings PhD, RD

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: eating disorders 1; dietary supplements 2; disordered eating 3; eating disorder risk factors 4

Online: 28 February 2023 (02:16:28 CET)

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Preprint REVIEW | doi:10.20944/preprints202407.1028.v1

Biomaterials in Drug Delivery and Clinical Applications

Nadia Islam, Aiša Galijatović, Selma Kozarić, Adna Hrapović, Ajla Tipura, Boris Kovalenko, Maida Hajdarpašić, Asmaa Al Bourghli, Haris Lokvančić, Abas Sezer, Alaa A. Aljabali, Murtaza M. Tambuwala, Altijana Hromić-Jahjefendić, Vladimir N. Uversky

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: biomaterials; drug delivery; clinical applications; ethics

Online: 15 July 2024 (10:48:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1918.v1

A Novel Image Compression Method Based on Coordinated Group Signal Transformation

Ekaterina Lopukhova, Grigory Voronkov, Igor Kuznetsov, Vladislav Ivanov, Ruslan Kutluyarov, Elizaveta Grakhova

Subject: Engineering, Telecommunications Keywords: energy-efficient coding; differential coding; coordinated group signal transformation; image compression; image quality criteria; neural networks

Online: 30 April 2024 (11:30:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1074.v1

Validation of Ground Based Solar Irradiance Measurements against Meteosat-Msg and Himawari-8 Satellite Data

Jitendra Kumar Meher, Syed Haider Abbas Rizvi, Bhramar Choudhary, Ravi Choudhary, Yash Thakre, Ritesh Kumar, Vikram Singh

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: BSRN; Heliosat-2; Himawari-8; Meteosat-MSG; Renewable energy; Solar Radiation; Validation Study

Online: 16 May 2024 (11:55:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.2249.v1

Assessment and Therapeutic Modulation of Heart Rate Variability: Potential Implications in Patients with COVID-19

Luiz G. Schnekenberg, Annahita Sedghi, Daniela Schöne, Lars-Peder Pallesen, Jessica Barlinn, Felix Woitek, Axel Linke, Volker Puetz, Kristian Barlinn, Norman Mangner, Timo Siepmann

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: SARS-CoV-2; COVID-19; heart rate variability; cardiac; cardiovascular; parasympathetic; sympathetic; autonomic

Online: 31 May 2023 (12:55:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0075.v1

A New Way to 2,3,4-Trisubstituted Benzo[h]quinolines: Synthesis, Consecutive Reactions and Cellular Activities

Viktor A. Zapol’skii, Sandra Kaul, Bianka Karge, Mark Brönstrup, Mimoza Gjikaj, Dieter E. Kaufmann

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: synthetic methods; 2-nitroperchlorobutadiene; benzoquinolines; cyclization; amines; sulfides; nucleophilic substitution; oxidation; medicinal chemistry

Online: 3 February 2023 (13:49:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0454.v1

The Silver Bullet: A Safe and Efficient Attenuated Vaccine for Viral Diseases Based on Biothermodynamics

Marko Popovic

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; SARS-CoV-2; Vaccine; Attenuation; Biothermodynamics; Gibbs energy; Permissiveness; Biosynthesis; Multiplication

Online: 23 December 2022 (08:15:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202106.0237.v1

Confounding Factors Influencing the Kinetic and the Magnitude of Serological Response Following Administration of BNT162b2

Jean-Louis Bayart, Laure Morimont, Mélanie Closset, Grégoire Wieërs, Tatiana Roy, Vincent Gerin, Marc Elsen, Christelle Eucher, Sandrine Van Eeckhoudt, Nathalie Ausselet, Clara David, François Mullier, Jean-Michel Dogné, Julien Favresse, Jonathan Douxfils

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: SARS-CoV-2; vaccine; BNT162b2; antibody, serology; kinetic; age; gender; BMI; blood-group.

Online: 8 June 2021 (13:48:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1352.v1

Personalized Assessment of Mortality Risk and Hospital Stay Duration in Hospitalized Patients with COVID-19 Treated with Remdesivir: A Machine Learning Approach

Antonio Ramón, Andrés Bas Castillo, Santiago Herrero González, Pilar Blasco, Miguel Suárez, Jorge Mateo

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: COVID-19; hospital stay; machine learning; mortality; SARS-CoV-2; remdesivir; XGB

Online: 24 February 2024 (08:57:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.2152.v1

Bottom Crack Detection with Real-Time Signal Amplitude Correction Using EMAT-PEC Composite Sensor

Yizhou Guo, Yu Hu, Kai Wang, Yini Song, Bo Feng, Yihua Kang, Zhaoqi Duan

Subject: Engineering, Electrical And Electronic Engineering Keywords: bottom crack; lift-off; EMAT; PEC; amplitude correction; signal fusion

Online: 26 July 2024 (10:21:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201707.0033.v1

Combination of Hypertension and High Fat and Cholesterol Diet Induces Severe Hepatic Inflammation in Rats via a Signaling Network Comprising NF-κB, MAPK, and Nrf2 Pathways

Yuan Yuan, Hisao Naito, Kazuya Kitamori, Tamie Nakajima

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: hepatic inflammation; high-fat-cholesterol diet; hypertension; mitogen-activated protein kinase; nonalcoholic steatohepatitis; nuclear factor erythroid 2-related factor 2 pathway; nuclear factor-kappa B; spontaneously hypertensive rat; stroke-prone spontaneously hypertensive5/Dmcr; Wistar Kyoto

Online: 14 July 2017 (10:54:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0749.v1

Ajwa Date Seed Mediated Green Synthesis of Alginate-Silver Nanocomposite Beads and Films for Antibacterial and Catalytic Degradation Applications

Naba Almukharraq, Marwa Almarzooqi, Hasan Ruyan, Fatima AlHannan, Praveen Kumar, Fryad Henari, G. Roshan Deen

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: Ajwa dates seed; silver nanoparticles; green synthesis; alginate beads; degradation;
2-nitrophenol, antibacterial activities

Online: 12 June 2024 (00:10:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1049.v1

How Aging Affects Insulin Resistance, Insulin Secretion, and Glucose Effectiveness in Subjects with Normal Blood Glucose and Body Weight

Li-Ying Huang, Chi-Hao Liu, Fang-Yu Chen, Chun-Heng Kuo, Pietro Pitrone, Jhih-Syuan Liu

Subject: Biology And Life Sciences, Aging Keywords: first-phase insulin secretion; second-phase insulin secretion; insulin resistance; glucose effectiveness; type 2 diabetes

Online: 27 April 2023 (05:23:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0262.v1

Isolation and Characterization of Erianthus arundinaceus Phosphate Transporter 1 (PHT1) Gene Promoter and 5′ Deletion Analysis of Transcriptional Regulation Regions under Phosphate Stress in Transgenic Tobacco

Murugan Naveenarani, HK Mahadevswamy, Sakthivel Surya Krishna, Channappa Mahadevaiah, Ramanathan Valarmathi, Markandan Manickavasagam, Muthukrishnan Arun, Govindakurup Hemaprabha, Chinnaswamy Appunu

Subject: Environmental And Earth Sciences, Soil Science Keywords: Erianthus arundinaceus; High-affinity phosphate transporter; PHT1; 2; Promoter analysis; Tobacco transgenic; Pi stress

Online: 5 October 2023 (12:04:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1592.v1

New Physically-Based Mathematical Model and Experiments for a Recently Invented Solar Pot

Márton Rátkai, Gábor Géczi, Richárd Kicsiny, László Székely

Subject: Engineering, Mechanical Engineering Keywords: solar cooking; solar pot; mathematical modelling; simulation results; measurements

Online: 24 June 2024 (08:16:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201612.0148.v1

Systemic Analysis of Certified Artisan Cheese Production for Improvement—The Case of the Serra da Estrela PDO Cheese

Denis A. Coelho, Tiago E. P. Carrola, Ana F. Couvinhas

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: process improvement; ewe’s cheese; systemic design

Online: 30 December 2016 (07:34:54 CET)

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The research reported on this paper was aimed at improving the overall efficiency of a PDO certified artisanal cheese production process. Being a PDO certified foodstuff by the EU, it is considered to have properties and qualities determined by the geographical environment in which is made, with its production taking place in a specific and determined geographical location, in this case the Serra da Estrela region. In that sense, the authors conducted a mapping according to a systemic perspective of the processes involved in the context of manufacturing and distribution of certified Serra da Estrela cheese. Numerous methods were used throughout the process, such as a systemic design analysis, and techniques derived from ethnographic methods, which led to the collection of data in the field and consequently provided the immersion of the researcher in genuine work situations. Critical points were identified and emphasized in the systemic map with the purpose of encouraging initiatives to address and overcome the gaps and inefficiencies detected. The systemic design analysis triggered the development of design work. Observations following an ethnographic approach identified ergonomic risks in cheese making during the process of cutting excess chips, fostering the emergence of musculoskeletal disorders at the wrist. A tool that fits best to the task at hand was developed. A prototype of the new tool enabled collecting feedback from use in the work context, in order to inform product development. The domains of agricultural production and microbiology, considering the specific microorganisms developed trough the ripening process of the cheese, turned out to be aspects of high importance for the issue under focus, contributing to a broader understanding of the ripening process and its risks, simultaneously improving the efficiency and success of cheese production. If it were not for the systemic analysis, which served as a link between the boundaries of distinct domains such as the risk of microorganism contamination, ergonomics, energy efficiency, legislation and regulation policies, transportation challenges and economic viability, approached throughout the research. Simultaneously creating bridges between them, the various problems might not have been detected in the first place, as they are usually addressed in specialized disciplines, predetermined by the restrictions of each specific area of knowledge. As a consequence of the development of this research, which was based on an analysis that sought to establish possible connections between various disciplines and tried to constantly maintain a holistic perspective, making new connections and observing the issues from a new angle, apart from the already established methodologies. All this allowed to lay out the seeds for the development of a plan to tackle the critical points identified by the systemic analysis reported in this paper.

Preprint REVIEW | doi:10.20944/preprints202311.1218.v1

Immunosenescence and Cytomegalovirus: Exploring Their Connection in the Context of Aging, Health, and Disease

Ludmila Müller, Svetlana Di Benedetto

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: aging; immunosenescence; cytomegalovirus; inflammaging; CMV latency; COVID-19; SARS-CoV-2; long COVID; age-related diseases

Online: 20 November 2023 (05:14:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.0826.v1

Potential Regulation of Iron Metabolism Gene Expression by DOF Transcription Factors in Dendrocalamus latiflorus

Peng-Kai Zhu, Mei-Xia Lin, Mei-Yin Zeng, Yu Tang, Xin-Rui Li, Tian-You He, Yu-Shan Zheng, Ling-Yan Chen

Subject: Biology And Life Sciences, Plant Sciences Keywords: DOF transcription factors; Iron Metabolism Related Genes; gene regulation; gene expression; Dendrocalamus latiflorus

Online: 10 July 2024 (10:14:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0009.v1

Integrating AI/ML Models for Patient Stratification Leveraging Omics Dataset and Clinical Biomarkers from COVID-19 Patients: A Promising Approach to Personalized Medicine

Babatunde Bello, Yogesh Naren Bundey, Roshan Bhave, Maksim Khotimchenko, Szczepan W. Baran, Kaushik Chakravarty, Jyotika Varshney

Subject: Medicine And Pharmacology, Other Keywords: SARS-CoV-2; COVID-19; artificial intelligence; omics; patient stratification; risk management

Online: 1 March 2023 (03:37:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202206.0255.v1

Short Linear Motifs in the Spike Protein of Sars-Cov-2 Variants Provide Clues Into Immune Hijack and Evasion Mechanisms of Omicron Variant

Anjana Soorajkumar, Ebrahim Alakraf, Mohammed Uddin, Stefan S Du Plessis, Alawi Alsheikh-Ali, Richard K. Kandasamy

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: coronaviruses; SARS-CoV-2; variant; Omicron; SLiMs; spike protein; motifs; covid-19

Online: 17 June 2022 (13:49:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0069.v1

Variability in the Control of Type 2 Diabetes in Primary Care and Its Association with Hospital Admissions for Vascular Events. The APNA Study.

Sara Guillen-Aguinaga, Luis Forga, Antonio Brugos-Larumbe, Francisco Guillen-Grima, Laura Guillen-Aguinaga, Ines Aguinaga-Ontoso

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Healthcare Disparities; Diabetes Mellitus, Type 2; Vascular Diseases; Primary Health Care; Cohort

Online: 3 September 2021 (14:58:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0548.v1

Transfer Learning for the Detection and Diagnosis of Types of Pneumonia Including Pneumonia Induced by the COVID-19 from Chest X-Ray Images

Yusuf Brima, Marcellin Atemkeng, Stive Tankio Djiokap, Jaures Ebiele, Franklin Tchakounté

Subject: Engineering, Automotive Engineering Keywords: ANN; COVID-19; CT; mRNA; MRI; RT-PCR; SARS-CoV-2; XCR

Online: 23 July 2021 (15:02:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0285.v1

Clinical, Laboratory, and Radiological Features Indicative of Novel Coronavirus Disease (COVID-19) in Emergency Departments – A Multicentre Case-Control Study in Hong Kong

Rex Pui Kin Lam, Kevin Kei Ching Hung, Eric Ho Yin Lau, Chun Tat Lui, Kin Ling Chan, Chin San Leung, Ion Wa Wong, Kin Wa Wong, Colin A. Graham, Patrick Chiu Yat Woo

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; SARS-CoV-2; emergency department; early diagnosis; case-control studies

Online: 17 May 2020 (08:27:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202211.0430.v1

Attenuation and Degeneration of SARS-CoV-2 Despite of Adaptive Evolution

Yingguang Liu

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2, evolution, immune evasion, codon usage, attenuation, genome degradation, degeneration, COVID-19

Online: 23 November 2022 (03:29:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0578.v1

A Note on Type 2 Degenerate Poly-Fubini Polynomials and Numbers

Waseem Khan

Subject: Computer Science And Mathematics, Mathematics Keywords: Modified degenerate polexponential function; Fubini polynomials; type 2 degenerate poly-Fubini polynomials; unipoly functions

Online: 24 September 2020 (10:52:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.2087.v1

SARS-CoV-2 and Influenza Vaccine Hesitancy during the COVID-19 Pandemic in a Dynamic Perspective

Valentina Gerussi, Maddalena Peghin, Alvisa Palese, Maria De Martino, Elena Graziano, Stefania Chiappinotto, Federico Fonda, Giulia Bontempo, Tosca Semenzin, Luca Martini, Miriam Isola, Carlo Tascini

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Influenza; COVID-19; SARS-CoV-2; Green-Pass; Vaccination; Immunization; Vaccine-hesitancy; Pandemic

Online: 29 June 2023 (10:23:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0565.v1

Physiological and Transcriptomic Analysis Provides Insights into Low Nitrogen Stress in Foxtail Millet (Setaria italica L.).

Erying Chen, Ling Qin, Feifei Li, Yanbing Yang, Zhenyu Liu, Xiao Yu, Jiahong Niu, Runfeng Wang, Huawen Zhang, Hailian Wang, Bin Liu, Yanan Guan

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: foxtail millet 1; nitrogen use efficiency 2; varieties3; physiological parameters 4; transcriptomics 5.

Online: 9 May 2023 (04:41:12 CEST)

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Foxtail millet (Setaria italica (L.) P. Beauv) is an important food and forage crop that is well adapted to nutrient-poor soils. However, little is known about how foxtail millet adapts to low nitrogen (LN) at the physiological and molecular levels. In the present study, two foxtail millet varieties with contrasting low nitrogen (LN) tolerance properties were investigated through integrative analyses of physiological featureparameters and transcriptomics. The physiological results showed that JG20 (high tolerance to LN) had higher biomass accumulation, nitrogen content and nitrogen use efficiency compared with JG22 (low tolerancesensitive to LN) under LN. JG20 had higher soluble sugar and soluble protein concentration in shoots compared with JG22 under LN, while contcentrations of soluble sugar and soluble protein contents were higher in the roots of JG22. Higher levels of CTK contentzeatin concentration were found in the shoots of JG20 com-pared with JG22, and a higher ABA contcentration was found in both the shoots and roots of JG22 compared with JG20 under LN. In the transcriptomics results, JG20 had more differentially ex-pressed genes (DEGs) than JG22 both in shoots and roots in response to LN. These LN-responsive genes were enriched in glycolysis, starch and sucrose metabolism, photosynthesis, biosynthesis of amino acids, hormone metabolism and nitrogen metabolism. Furthermore, the high-affinity nitrate transporter gene, SiNRT2.1, and glutamine synthetase gene, SiGS5, chlorophyll apoprotein of photosystem II gene, SiPsbQ, ATP synthase subunit gene, b, auxin-responsive protein gene, SiIAA25, and aldose 1-epimerase gene, SiAEP, in shoots, and high-affinity nitrate transporter gene, SiNRT2.3, SiNRT2.4, and glutamate synthase gene, SiGOGAT2, auxin-responsive protein gene, SiIAA4, fructose-bisphosphate aldolase gene, SiAEP5, in root, were important genes in-volved in the LN tolerance of foxtail millet. These results provide a detailed description of the physiological and transcriptome response of foxtail millet under LN condition.

Preprint ARTICLE | doi:10.20944/preprints202209.0084.v2

The CSHQ-DE Questionnaire Uncovers Relevant Sleep Disorders in Children and Adolescents with Long COVID-19

Sarah Werner, Claus Doerfel, Richard Biedermann, Michael Lorenz, Marius Rasche, Hans Proquitté, Lars Newman, Daniel Vilser

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: long COVID; Post COVID-19 condition; sleep disorders, SARS-CoV-2; Coronavirus; children

Online: 14 October 2022 (10:13:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202204.0009.v1

How Smell Regulates Metabolism: The Role Of Ectopically Expressed Olfactory Receptors In Lipid and Glucose Homeostasis

Ginevra Urbani, Eleonora Distrutti, Michele Biagioli, Silvia Marchianò, Stefano Fiorucci

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: olfactory receptors; glucose metabolism; type 2 diabetes mellitus; lipid metabolism; NAFLD; metabolic syndrome

Online: 2 April 2022 (09:00:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0481.v1

Minimizing Errors in RT-PCR Detection and Quantification of SARS-CoV-2 RNA for Wastewater Surveillance

Warish Ahmed, Stuart Simpson, Paul Bertsch, Kyle Bibby, Aaron Bivins, Linda Blackall, Silvia Bofill-Mas, Albert Bosch, Joao Brandao, Phil Choi, Mark Ciesielski, Erica Donner, Nishita D'Souza, Andreas Farnleitner, Daniel Gerrity, Raul Gonzalez, John Griffith, Pradip Gyawali, Charles Haas, Kerry Hamilton, Chanditha Hapuarachchi, Valerie Harwood, Rehnuma Haque, Greg Jackson, Stuart Khan, Wesaal Khan, Masaaki Kitajima, Asja Korajkic, Giuseppina La Rosa, Blythe Layton, Erin Lipp, Sandra McLellan, Brian McMinn, Gertjan Medema, Suzanne Metcalfe, Wim Meijer, Jochen Mueller, Heather Murphy, Colleen Naughton, Rachel Noble, Sudhi Payyappat, Susan Petterson, Tarja Pitkanen, Veronica Rajal, Brandon Reyneke, Fernando Roman, Joan Rose, Marta Rusinol, Michael Sadowsky, Laura Sala-Comorera, Yin Xiang Setoh, Samendra Sherchan, Kwanrawee Sirikanchana, Wendy Smith, Joshua Steele, Rosalie Sabburg, Erin Symonds, Phong Thai, Kevin Thomas, Josh Tynan, Simon Toze, Janelle Thompson, Andy Whiteley, Judith Wong, Daisuke Sano, Stefan Wuertz, Irene Xagoraraki, Qian Zhang, Amity Zimmer-Faust, Orin Shanks

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: COVID-19; SARS-CoV-2; Wastewater; Surveillance; False-positive; False-negative; RT-PCR

Online: 19 April 2021 (13:08:13 CEST)

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Wastewater surveillance for pathogens using the reverse transcription-polymerase chain reaction (RT-PCR) is an effective, resource-efficient tool for gathering additional community-level public health information, including the incidence and/or prevalence and trends of coronavirus disease-19 (COVID-19). Surveillance of SARS-CoV-2 in wastewater may provide an early-warning signal of COVID-19 infections in a community. The capacity of the world’s environmental microbiology and virology laboratories for SARS-CoV-2 RNA characterization in wastewater is rapidly increasing. However, there are no standardized protocols nor harmonized quality assurance and quality control (QA/QC) procedures for SARS-CoV-2 wastewater surveillance. This paper is a technical review of factors that can lead to false-positive and -negative errors in the surveillance of SARS-CoV-2, culminating in recommendations and strategies that can be implemented to identify and mitigate these errors. Recommendations include, stringent QA/QC measures, representative sampling approaches, effective virus concentration and efficient RNA extraction, amplification inhibition assessment, inclusion of sample processing controls, and considerations for RT-PCR assay selection and data interpretation. Clear data interpretation guidelines (e.g., determination of positive and negative samples) are critical, particularly during a low incidence of SARS-CoV-2 in wastewater. Corrective and confirmatory actions must be in place for inconclusive and/or potentially significant results (e.g., initial onset or reemergence of COVID-19 in a community). It will also be prudent to perform inter-laboratory comparisons to ensure results are reliable and interpretable for ongoing and retrospective analyses. The strategies that are recommended in this review aim to improve SARS-CoV-2 characterization for wastewater surveillance applications. A silver lining of the COVID-19 pandemic is that the efficacy of wastewater surveillance was demonstrated during this global crisis. In the future, wastewater will play an important role in the surveillance of a range of other communicable diseases.

Preprint ARTICLE | doi:10.20944/preprints202002.0308.v1

Pharmacoinformatics and Molecular Dynamic Simulation Studies Reveal Potential Inhibitors of SARS-CoV-2 Main Protease 3CL^pro

Mubarak A. Alamri, Muhammad Tahir ul Qamar, Safar M. Alqahtani

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: SARS-CoV-2; COVID-19; 3CL protease; molecular docking; molecular dynamics and simulations

Online: 23 February 2020 (02:17:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1328.v1

Sustainable Development of Rural Settlements on Stara Planina Mountain in Serbia through Preserving Its Built Heritage

Ana Niković, Božidar Manić

Subject: Environmental And Earth Sciences, Other Keywords: Serbia; Stara Planina Mountain; typical rural settlements; conservation; planning; sustainable development

Online: 21 March 2024 (16:21:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1504.v2

Dual Release of Daptomycin and BMP-2 from a Composite of β-TCP Ceramic and ADA Gelatin for Bone Regeneration

Lucas Ritschl, Pia Schilling, Annette Wittmer, Annerose Serr, Hagen Schmal, Michael Seidenstuecker

Subject: Biology And Life Sciences, Life Sciences Keywords: dual release, daptomycin, BMP-2, β-TCP scaffold, ADA-gelatin gel, bone infection, bone regeneration

Online: 24 November 2023 (08:41:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0075.v2

Structural, Magnetic and Mossbauer studies of Transition metal doped Gd2Fe16Ga0.5TM0.5 intermetallic compounds (TM=Cr, Mn, Co, Ni, Cu, and Zn)

Jiba Dahal, Syed Ali Kalangala Sikkanther Batcha, Jahangir Alam

Subject: Chemistry And Materials Science, Electronic, Optical And Magnetic Materials Keywords: Permanent magnetic materials, 2:17 intermetallics, Mossbauer Spectroscopy, Curie temperature, X-ray diffraction, Rietveld analysis

Online: 5 October 2018 (11:59:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1144.v1

Linking Wetland Ecosystem Services to Fish Genetic Resources with Special Reference to Hilsa Shad (Tenualosa ilisha): A Novel Study from Northeastern Bangladesh

Atiqur Rahman Sunny, Md. Arifur Rahman, Md. Nazmul Hasan, Jeba Faizah Rahman, Sharif Ahmed Sazzad, Md. Faruque Miah, Md. Ashrafuzzaman, Shamsul Haque Prodhan

Subject: Biology And Life Sciences, Aquatic Science Keywords: Wetland; Ecosystem services; Genetic diversity; Hilsa; Bangladesh

Online: 20 February 2024 (12:44:47 CET)

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Preprint REVIEW | doi:10.20944/preprints202305.0041.v1

A Significance of an Amelioration of Endothelial Dysfunction by Sodium-Glucose Cotransporter 2 Inhibitors for an Improvement of Heart Failure and Chronic Kidney Disease

Hidekatsu Yanai, Hiroki Adachi, Mariko Hakoshima, Hisayuki Katsuyama

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: endothelial dysfunction; chronic kidney disease; heart failure; sodium-glucose cotransporter 2 inhibitors

Online: 2 May 2023 (02:18:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2295.v1

Application of Experimental Configurations of Seismic and Electric Tomographic Techniques to the Investigation of Complex Geological Structures

Vasileios Gkosios, John D. Alexopoulos, Konstantinos Soukis, Ioannis-Konstantinos Giannopoulos, Spyridon Dilalos, Dimitrios Michelioudakis, Nicholas Voulgaris, Thomas Sphicopoulos

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: ERT; SRT; seismic sources comparison; spectral analysis; forward modelling; GPR; magmatic intrusion

Online: 29 July 2024 (11:01:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0060.v1

A Survey on Potentially Beneficial and Hazardous Bioactive Compounds in Cocoa Powders Samples Sourced from European Market

Luigi Esposito, Matteo Perillo, Carla Daniela Di Mattia, Annalisa Scroccarello, Flavio Della Pelle, Dario Compagnone, Giampiero Sacchetti, Dino Mastrocola, Maria Martuscelli

Subject: Biology And Life Sciences, Food Science And Technology Keywords: biogenic amines; polyphenols; salsolinol; organic processing; raw cocoa; alkalization treatment

Online: 1 July 2024 (09:21:29 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202404.1727.v1

Persistently High Platelet Factor 4 Levels in an Adolescent With Recurrent Late Thrombotic Complications After SARS-CoV-2 mRNA Vaccination

Yoichi Haga, Akira Ohara, Tsuneyoshi Yakuwa, Akari Yamashita, Midori Udo, Masaki Matsuoka, Hiroshi Ohara, Atsushi Yasumoto, Hiroyuki Takahashi

Subject: Medicine And Pharmacology, Hematology Keywords: ; platelet factor 4; SARS-CoV-2 vaccine; venous thrombosis; antiphospholipid syndrome; anticoagulants ;

Online: 28 April 2024 (07:30:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.2096.v1

The ANSI/373 Standard: An Examination of a Voluntary Sustainability Initiative for Processing and Distributing Dimension Stone

Erin M. Ashbee, Michal J. Bardecki

Subject: Environmental And Earth Sciences, Other Keywords: dimension stone; ANSI/373 standard; voluntary sustainability initiatives; certification compliance; green building materials

Online: 29 August 2024 (08:46:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1629.v1

Continuous Casting Preparation Process of Helical Fiber Reinforced Metal Matrix Composites

Hui Yang, Ming Chang, Chun jing Wu

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: Helical fiber; Metal Matrix composites; Continue Casting; Process Model; Mechanical properties

Online: 24 June 2024 (08:50:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.2020.v1

Safe Robust Adaptive Motion Control for Underactuated Marine Robots

G. Reza Nazmara, A. Pedro Aguiar

Subject: Engineering, Control And Systems Engineering Keywords: Marine Robots; Funnel Control; Backstepping Control; Fuzzy Systems; Finite-time Stability

Online: 30 May 2024 (13:16:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1229.v1

Regenerative Potential of Demineralized Dentin-Derived Graft Material in Rabbit Calvaria: A Histomorphometric Study

Bounghoon Lee, Hyunsuk Choi, Dong-Seok Sohn

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: guided bone regeneration; rabbit calvaria; histology; dentin-derived matrix

Online: 20 May 2024 (15:59:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0450.v1

Can Environmental Regulation Enhance Green Total Factor Productivity? —Evidence from 107 Cities in the Yangtze River Economic Belt

Mengli Liu, Yan Zhu, Jingjing Zhang

Subject: Business, Economics And Management, Economics Keywords: Environmental regulation; Green total factor productivity; Yangtze River Economic Belt

Online: 8 April 2024 (13:55:03 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202311.1400.v1

Preclinical and Clinical Observations Implying Combination Therapy to Enhance the Efficacy of the Her-2/Neu B Cell Peptide-Based Vaccine Her-Vaxx and to Prevent Immune Evasion

Joshua Tobias, Sandra Högler, Martin Raigel, Diego Shih-Chieh Lin, Yee Chao, Lukas Kenner, Erika Garner-Spitzer, Sharon Yavrom, Nicholas J. Ede, Christoph C. Zielinski, Michael Kundi, Ursula Wiedermann

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: PD-L1; Her-2/neu; Expression; Preclinical and clinical settings; Immune evasion; Combination therapy

Online: 22 November 2023 (07:30:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0588.v1

Honors and Costs of Being Heroes: Risk Factors and Epidemiology of COVID-19 Infection among Health Care Workers of a Severely Hit COVID-19-Referral Hospital in Italy

Marta Colaneri, Viola Novelli, Sara Cutti, Alba Muzzi, Guido Resani, Cristina Monti, Claudia Rona, Anna Maria Grugnetti, Marco Rettani, Francesca Rovida, Valentina Zuccaro, Antonio Triarico, Carlo Marena

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: retrospective cohort study; COVID-19; SARS-CoV-2; health care workers; risk of infection

Online: 27 August 2020 (03:25:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1606.v1

Identification of Stage-Specific microRNAs That Govern the Early Stages of Sequential Oral Oncogenesis by Strategically Bridging Genetics and Epigenetics

Iphigenia Gintoni, Stavros Vassiliou, George Chrousos, Christos Yapijakis

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Oral squamous cell carcinoma; OSCC; oral cancer; miRNA; miRNA expression; genes; gene expression; hyperplasia; dysplasia; early invasion; early stage OSCC; in situ carcinoma; precancerous lesions; animal model; early diagnosis; liquid biopsy

Online: 24 May 2024 (08:38:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1146.v2

Acetate Alleviates Gut Microbiota Depletion-Induced Retardation of Skeletal Muscle Growth and Development in Young Mice

Guitao YANG, Jinwei Zhang, Yan LIU, Jing SUN, Liangpeng GE, Lu LU, Keren LONG, Xuewei LI, Dengfeng XU, Jideng MA

Subject: Biology And Life Sciences, Life Sciences Keywords: gut microbiota, acetate, skeletal muscle, Gm16062,

Online: 13 May 2024 (13:31:55 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.0932.v1

Targeting the Metabolic Paradigms in Cancer and Diabetes

Mira Bosso, Dania Haddad, Ashraf Al Madhoun, Fahd Al-Mulla

Subject: Biology And Life Sciences, Life Sciences Keywords: oxidative phosphorylation; cancer; mitochondria; metabolic shift; type 2 diabetes; insulin resistance; therapy; nutritional adjuvants; glutaminolysis

Online: 13 December 2023 (03:26:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.1223.v1

Estimating Subsurface Thermohaline Structure in the Tropical Western Pacific Using DO-ResNet Model

Xianmei Zhou, Shanliang Zhu, Wentao Jia, Hengkai Yao

Subject: Environmental And Earth Sciences, Oceanography Keywords: AI oceanography; machine learning; ocean thermohaline structure; remote sensing data; tropical Western Pacific

Online: 16 July 2024 (10:55:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0195.v1

Divergent Effects of Glycemic Control and Bariatric Surgery on Circulating Concentrations of TMAO in Newly Diagnosed T2D Patients and Morbidly Obese

Marina Canyelles, Antonio Pérez, Alexandra Junza, Inka Miñambres, Oscar Yanes, Helena Sardà, Noemí Rotllan, Josep Julve, Sònia Benitez, José Luis Sánchez-Quesada, Mireia Tondo, Joan Carles Escolà-Gil, Francisco Blanco-Vaca

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: γ-butyrobetaine; glycemic control; liquid chromatography–mass spectrometry; obesity; trimethylamine N-oxide; type 2 diabetes

Online: 14 September 2022 (08:08:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0696.v1

Is the β₃-Adrenoceptor a Valid Target for the Treatment of Obesity and/or Type 2 Diabetes?

Haneen S. Dwaib, Martin C. Michel

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: β3-adrenoceptor; obesity; type 2 diabetes; species difference; insulin release; glucose uptake; thermogenesis

Online: 11 October 2023 (14:22:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1362.v1

The Rise and Fall of Omicron BA.1 Variant as Seen in Wastewater Supports Epidemiological Model Predictions

Michal Liddor Naim, Yu Fu, Marilou Shagan, Itay Bar-Or, Robert Marks, Qun Sun, Rony Granek, Ariel Kushmaro

Subject: Public Health And Healthcare, Health Policy And Services Keywords: SARS-CoV-2; Omicron; Wastewater-based epidemiology; RT-qPCR; SIR model; SIRS model

Online: 20 July 2023 (11:44:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0334.v1

Molecular Docking and Molecular Dynamic Study of Two Viral Proteins Associated with SARS-CoV-2 with Ivermectin

Lenin Andres Gonzalez Paz, Carla A. Lossada, Luis S. Moncayo, Freddy Romero, J. L. Paz, Joan Vera-Villalobos, Aleivi E. Perez, Ernesto San-Blas, Ysaias J. Alvarado

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: SARS-COV-2; folding/unfolding; antiparasitic; molecular docking; molecular dynamics; COVID-19; Ivermectin

Online: 19 April 2020 (06:56:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0231.v1

Experimental Optimization of Natural Gas Injection Timing in a Dual-Fuel Marine Engine to Minimize GHG Emissions

Luigi De Simio, Luca Marchitto, Sabato Iannaccone, Vincenzo Pennino, Nunzio Altieri

Subject: Engineering, Marine Engineering Keywords: marine engine; GHG reduction; natural gas; phased injection

Online: 5 June 2024 (14:17:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0050.v1

Application of a Novel WENO Scheme for RANS and RANS/LES Coupled Simulations in Turbomachinery Flows

Hao Wang, Dongdong Zhong, Shuo Zhang, Xingshuang Wu, Ning Ge

Subject: Engineering, Aerospace Engineering Keywords: WENO scheme; turbomachinery flow; NUAA-Turbo; RANS; RANS/LES coupled simulations

Online: 1 May 2024 (07:01:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0830.v1

A New Type of WENO Scheme for Large Eddy Simulation of Turbomachinery Flows

Shuo Zhang, Dongdong Zhong, Hao Wang, Xingshuang Wu, Ning Ge

Subject: Engineering, Aerospace Engineering Keywords: WENO scheme; turbomachinery flow; NUAA-Turbo; large scale engineering application; LES

Online: 12 April 2024 (08:07:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0447.v1

Experimental Evaluation of SAT Attack on Logic Locking

Milan Vojvoda, Viliam Hromada, Filip Janikovský, Jozef Kučerák, Matúš Jókay

Subject: Computer Science And Mathematics, Security Systems Keywords: logic locking; piracy protection; SAT attack

Online: 7 March 2024 (11:17:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints201612.0017.v1

Microstructure and Tribological Properties of Mo-40Ni-13Si Multiphase Intermetallic Alloy

Chunyan Song, Shuhuan Wang, Yongliang Gui, Zihao Cheng, Guolong Ni

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: intermetallic; refractory metal; tribological property; toughening

Online: 2 December 2016 (11:04:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints201611.0082.v1

A Node Localization Algorithm Based on Multi-Granularity Regional Division and the Lagrange Multiplier Method in Wireless Sensor Networks

Fengjun Shang, Yi Jiang, Anping Xiong, Wen Su, Li He

Subject: Computer Science And Mathematics, Information Systems Keywords: WSN; RSSI; Voronoi diagram; vector similar degrees; Lagrange

Online: 16 November 2016 (13:10:52 CET)

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With the integrated development of the Internet, wireless sensor technology, cloud computing, and mobile Internet, there has been a lot of attention given to research about and applications of the Internet of Things. A Wireless Sensor Network (WSN) is one of the important information technologies in the Internet of Things; it integrates multi-technology to detect and gather information in a network environment by mutual cooperation, using a variety of methods to process and analyze data, implement awareness, and perform tests. This paper mainly researches the localization algorithm of sensor nodes in a wireless sensor network. Firstly, a multi-granularity region partition is proposed to divide the location region. In the range-based method, the RSSI (Received Signal Strength indicator, RSSI) is used to estimate distance. The optimal RSSI value is computed by the Gaussian fitting method. Furthermore, a Voronoi diagram is characterized by the use of dividing region. Rach anchor node is regarded as the center of each region; the whole position region is divided into several regions and the sub-region of neighboring nodes is combined into triangles while the unknown node is locked in the ultimate area. Secondly, the multi-granularity regional division and Lagrange multiplier method are used to calculate the final coordinates. Because nodes are influenced by many factors in the practical application, two kinds of positioning methods are designed: the unknown node is in the positioning unit or not. When the unknown node is on the side of the positioning unit, we use the method of vector similarity. Moreover, we use the centroid algorithm to calculate the ultimate coordinates of unknown node. When the unknown node is not on the side of the positioning unit, we establish a Lagrange equation containing the constraint condition to calculate the first coordinates. Furthermore, we use the Taylor expansion formula to correct the coordinates of the unknown node. In addition, this localization method has been validated by establishing the real environment.

Preprint ARTICLE | doi:10.20944/preprints201610.0075.v1

EEG Signal Recognition Based on Wavelet Transform and ACCLN Network

Xuebin Qin, Jun Deng, Mei Wang, Yizhe Zhang, Pai Wang

Subject: Computer Science And Mathematics, Signal Processing Keywords: BCI; recognition; feature extraction; ACCLN network; RBF network

Online: 19 October 2016 (10:09:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0516.v1

SGLT -2 Inhibitors and the Inflammasome: What's next in the 21st century?

Dimitris Kounatidis, Natalia Vallianou, Angelos Evangelopoulos, Ioannis Vlachodimitris, Eugenia Grivakou, Evangelia Kotsi, Krystalia Dimitriou, Alexandros Skourtis, Iordanis Mourouzis

Subject: Medicine And Pharmacology, Internal Medicine Keywords: SGLT-2 Inhibitors; Inflammasome; NLRP3; reno-protective effects; Cardio-protective effects; neuro-protective effects.

Online: 18 April 2023 (10:33:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202010.0407.v2

Vitamin C—An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19

Patrick Holford, Anitra Carr, Thomas H. Jovic, Stephen R. Ali, Iain S. Whitaker, Paul Marik, David Smith

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; SARS-CoV-2; coronavirus; vitamin C; ascorbate; colds; pneumonia; sepsis; immunonutrition; supplementation

Online: 30 November 2020 (15:23:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0552.v1

Molecular Sensomics Combined with Random Forest Model to Reveal the Evolution on Flavor Type of Baijiu Based on Differential Markers

He Huang, Yiyuan Chen, Yaxin Hou, Jiaxin Hong, Hao Chen, Dongrui Zhao, Jihong Wu, Jinchen Li, Jinyuan Sun, Xiaotao Sun, Mingquan Huang, Baoguo Sun

Subject: Biology And Life Sciences, Food Science And Technology Keywords: baijiu; flavor type; sensory evaluation; differential marker; correlation analysis; random forest

Online: 6 September 2024 (13:48:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1957.v1

Mild Phenotypes of Gyrate Atrophy in a Carrier with One Variant Allele of OAT

Yuqiao Ju, Xiao Li, Fengjuan Gao, Qing Chang, Yuan Zong, Xin Huang

Subject: Medicine And Pharmacology, Ophthalmology Keywords: gyrate atrophy of the choroid and retina (GACR); OAT gene; carrier; allele; autosomal recessive

Online: 30 April 2024 (07:28:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0746.v1

Are We Able to Prevent Neonatal Readmission? A Retrospective Analysis from a Pediatrics Department in Ploiești – Romania

Ioana Roșca, Andreea Teodora Constantin, Daniela Eugenia Popescu, Ana Maria Cristina Jura, Anca Miu, Alina Turenschi

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: neonatal; readmission; newborns; pediatrics; malnutrition; breastfeeding; multidisciplinary team; public health; inclusion; equity.

Online: 13 February 2024 (12:28:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1529.v1

Epidemiological Evolution and Economic Impact of the COVID-19 Pandemic in the European Union and Worldwide and Effects of Control Strategies on Them: A Descriptive Study

Joan A. Caylà, Josep M Bellmunt, Josep M Jansà, Andrés Marco, Joan-Pau Millet

Subject: Public Health And Healthcare, Health Policy And Services Keywords: COVID-19; SARS-CoV-2; mitigation strategy; Zero-COVID strategy; prevention; control; gross domestic product; evaluation

Online: 22 September 2023 (07:41:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.2278.v1

Binary Biomass-Based Electrolyte Films for High-Performance All-Solid-State Supercapacitor

Rui Lou, Guocheng Zhang, Taoyuan Niu, Long He, Yuejin Yuan, Ying Su, Guodong Wei

Subject: Engineering, Energy And Fuel Technology Keywords: lignin nanoparticles; sodium alginate; solid electrolyte; supercapacitor; electrochemical

Online: 31 August 2024 (18:19:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201612.0116.v1

Remote Control for Robot Walking via Gesture Detected by Inertial Sensor

Na Xiang, Fa-fa Wang, Bin-bin Wang, Sheng-lun Yi, Xue-bo Jin, Ting-li Su, Jian-lei Kong, Yu-ting Bai

Subject: Engineering, Control And Systems Engineering Keywords: inertial sensor; finger gesture; NAO humanoid robot; quaternions; motion capture

Online: 23 December 2016 (10:31:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.1819.v2

3D-Printed Phenylboronic Acid-Bearing Hydrogels for Glucose-Triggered Drug Release

Jeremy Odent, Nicolas Baleine, Serena Maria Torcasio, Sarah Gautier, Olivier Coulembier, Jean-Marie Raquez

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: 3D printing; drug eluting implants; glucose responsiveness

Online: 20 August 2024 (12:36:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2590.v1

Assessing the Reliability of the Sexual Violence Questionnaire in Sport Among Spanish-Speaking Athletes

Andrea Sáenz-Olmedo, Aitor Iturricastillo, Jon Brain, Luis Maria Zulaika, Oidui Usabiaga

Subject: Social Sciences, Gender And Sexuality Studies Keywords: Sexual violence; experiences; perceptions; coach-athlete relationship; sport

Online: 1 August 2024 (05:39:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1834.v1

Novel Metabolites Associated with Decreased Gfr: A 12-Year Follow-Up of the METSIM Cohort

Lilian Fernandes Silva, Jagadish Vangipurapu, Anniina Oravilahti, Markku Laakso

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Genetics; metabolomics; type 2 diabetes; glomerular filtration rate

Online: 26 August 2024 (11:26:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1743.v1

A Multi-target Pharmacological Correction of a Lipoyltransferase LIPT1 Gene Mutation in Patient-Derived Cellular Models

David Gómez-Fernández, Ana Romero-González, Juan M. Suárez-Rivero, Paula Cilleros-Holgado, Mónica Álvarez-Córdoba, Rocío Piñero-Pérez, José Manuel Romero-Domínguez, Diana Reche-López, Alejandra López-Cabrera, Salvador Ibañez-Mico, Marta Castro de Oliveira, Andrés Rodríguez-Sacristán, Susana Gónzalez-Granero, José Manuel García-Verdugo, José A Sánchez-Alcázar

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: LIPT1; SIRT3; fibroblasts; lipoylation; bioenergetics; 2-ketoacid dehydrogenase

Online: 22 July 2024 (14:19:16 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202401.0503.v1

Hibernating Bats are a Weak Source for Biomonitoring of Coronaviruses

Aleksander Goll, Lara Dutra, Joanna Nowicka, Elena Sgarabotto, Vinaya Venkat, Grzegorz Apoznański, Tomasz Kokurewicz, Alek Rachwald, Lukasz Rabalski, Hussein Alburkat, Jenni Virtanen, Tarja Sironen, Ravi Kant, Vincent Bourret, Maciej Grzybek

Subject: Biology And Life Sciences, Virology Keywords: bat-borne diseases; biomonitoring; coronaviruses; SARS-CoV-2

Online: 5 January 2024 (14:50:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1078.v1

Immunogenicity of Tetravalent Protein Vaccine, SCTV01E-2 against SARS-CoV-2 EG.5 Subvaraint: a Phase 2 Trial

Jihai Tang, Qinghua Xu, Chaoyin Zhu, Kun Xuan, Tao Li, Qingru Li, Xingya Pang, Zhenqiu Zha, Jinwei Li, Liyang Qiao, Haiyang Xu, Gang Wu, Yan Tian, Jun Han, Cuige Gao, Gui Qian, Xuxin Tian, Liangzhi Xie

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Safety; Immunogenicity; SARS-CoV-2; Multivalent vaccine; Booster

Online: 15 December 2023 (01:43:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0533.v1

ERK1 Is a Regulatory Kinase Coordinating ERK2 Function in Colon Adenocarcinoma

Alessia Parascandolo, Giulio Benincasa, Francesco Corcione, Mikko O. Laukkanen

Subject: Biology And Life Sciences, Life Sciences Keywords: Colon tumorigenesis; ERK1/2; SOD3; migration, invasion; proliferation

Online: 8 December 2023 (04:56:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1716.v1

Boosting Mitochondrial Biogenesis Diminishes Foam Cell Formation in the Post-Stroke Brain

Sanna H. Loppi, Marco A. Tavera-Garcia, Natalie E. Scholpa, Boaz K. Maiyo, Danielle A. Becktel, Helena W. Morrison, Rick G. Schnellmann, Kristian P. Doyle

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: stroke; aging; mitochondrial biogenesis; beta-2-adrenergic activation

Online: 26 October 2023 (12:16:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1185.v1

Monitoring Coastal Waves with ICESat-2

James T. Dietrich, Lori A. Magruder, Matthew Holwill

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: ICESat-2; coastal waves; remote sensing of waves

Online: 18 October 2023 (11:46:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.0897.v1

SARS-CoV-2: An Update on the Biological Interplay with the Human Host

Giuseppe Lippi, Fabian Sanchis-Gomar, Camilla Mattiuzzi, Brandon M. Henry

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: COVID-19; SARS-CoV-2; Coronavirus; Biology; Genetics

Online: 14 September 2023 (03:41:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0030.v1

Effectiveness of Oral Versus Injectable Semaglutide in Adults with Type 2 Diabetes: Results from a Retrospective Observational Study in Croatia

Sanja Klobučar, Andrej Belančić, Iva Bukša, Nikolina Morić, Dario Rahelić

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: glucagon-like peptide-1; semaglutide; type 2 diabetes

Online: 1 September 2023 (07:49:49 CEST)

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Background: The number of people with type 2 diabetes is increasing daily, and therefore effective therapy is needed to successfully regulate glycemia and reduce the risk of associated complications. Recently, an oral formulation of the glucagon-like peptide-1 receptor agonist (GLP-1 RA) semaglutide has become available. Therefore, the aim of our study was to compare the effectiveness of the new oral formulation and the existing injectable formulation of semaglutide in terms of glycemic and body weight control in a real-world setting. Patients and methods: This was a single-center retrospective observational study conducted at the Rijeka Clinical Hospital Centre. A total of 106 patients with inadequately controlled type 2 diabetes (HbA1 ≥ 7%) on different oral or basal insulin supported oral therapy were recruited from the diabetes outpatient clinic, and data from electronic medical records were retrospectively collected and analyzed from May 2021 to November 2022. All subjects were GLP-1 RA naive and consequently prescribed 0.5 or 1.0 mg once weekly injectable semaglutide (IS) or 7 mg or 14 mg once daily oral semaglutide (OS) for at least 6 months. Glycated hemoglo-bin (HbA1c), body weight, and body mass index (BMI) were assessed prior to semaglutide administration and after a 6-month follow-up period. The primary endpoint was the change from baseline in HbA1c, and sec-ondary endpoints were the change in body weight and the proportion of participants with a reduction in body weight of ≥ 5% and ≥ 10%, respectively, 6 months after the initiation of semaglutide treatment. Results: At 6-month follow-up, no significant difference was observed between the two formulations in terms of HbA1c reduction (IS -1.1% vs OS -1.4%, p=0.126) and weight loss (IS -6.50 kg vs OS -5.90 kg, p=0.714). Exactly the same proportion of participants in both groups achieved a weight loss of ≥ 5% (56.7%, n=30). A weight loss ≥ 10% was observed in 20.7% (n=11) of participants administered IS and 15.1% (n=8) of participants adminis-tered OS, respectively (p=0.454). Conclusion: In a real-world setting, oral semaglutide as add-on therapy to ongoing antihyperglycemic treatment in patients with inadequately controlled type 2 diabetes who had not previously received GLP-1 RA demonstrated the same effectiveness as injectable semaglutide in terms of gly-cemic control and weight loss after 6 months of treatment.

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