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Preprint REVIEW | doi:10.20944/preprints202005.0260.v2

COVID-19 Pandemic: Insights into Structure, Function, and hACE2 Receptor Recognition by SARS-CoV-2

Anshumali Mittal, Kavyashree Manjunath, Rajesh Kumar Ranjan, Sandeep Kaushik, Sujeet Kumar, Vikash Verma

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; SARS-CoV; SARS-like coronavirus; 2019-nCoV; SARS-CoV-2; angiotensin-converting enzyme 2 (ACE2); RdRp; Remdesivir; and neutralizing antibody

Online: 10 July 2020 (16:21:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0114.v1

A Note on Type 2 Degenerate Poly-Cauchy Polynomials and Numbers of the Second Kind

Waseem Khan

Subject: Computer Science And Mathematics, Analysis Keywords: degenerate polylogarithm functions; degenerate poly-Cauchy polynomials; degenerate unipoly-Cauchy polynomials

Online: 7 July 2020 (08:20:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints202006.0041.v1

SARS-CoV-2 Existence in Different Types of Biological Specimens and Leading Public Health Concern

Priyanka Yadav

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: SARS-CoV-2; COVID-19; 2019-nCOV; Shedding; Detection

Online: 4 June 2020 (17:34:28 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202005.0177.v1

Interference of SARS-CoV-2 with the Homeostasis of Ventilation and Perfusion in the Lung

Clemente F. Arias, Francisco J. Acosta, Federica Bertocchini, Cristina Fernández-Arias

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: SARS-CoV-2; COVID-19; homeostasis; hypoxic pulmonary vasoconstriction; renin-angiotensin system; hydrostatic edema; permeability edema

Online: 10 May 2020 (17:22:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0040.v2

Expression Pattern of the SARS-CoV-2 Entry Genes ACE2 and TMPRSS2 in the Respiratory Tract

Yichuan Liu, Hui-Qi Qu, Jingchun Qu, Lifeng Tian, Hakon Hakonarson

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: ACE2; COVID-19; SARS-CoV-2; TMPRSS2

Online: 28 September 2020 (03:19:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0329.v1

Identification of Pharmacophoric Features and Novel Compounds for Inhibition of SARS-Cov-2 Main Protease

Priti Jain, Rupesh Dorik, Munendra Jain

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: SARS-CoV-2; COVID-19; protease; docking; pharmacophore; Zinc15

Online: 19 April 2020 (05:33:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0409.v2

YoungJoon Park, Ju Won Ahn, Sojung Hwang, Kyoung Su Sung, Jaejoon Lim, KyuBum Kwack

Subject: Biology And Life Sciences, Virology Keywords: angiotensin-converting enzyme 2; SARS-CoV-2; spike protein; COVID-19

Online: 9 April 2020 (09:59:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202002.0399.v1

Preliminary Case Report on the SARS-CoV-2 Cluster in the UK, France, and Spain

Emma B. Hodcroft

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19 SARS-CoV-2 hCOV-19 coronavirus epidemiology contact-tracing cluster outbreak epidemic

Online: 27 February 2020 (11:08:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints201812.0368.v1

An Integrated Best-Worst and Interval Type-2 Fuzzy TOPSIS Methodology for Green Supplier Selection

Melih Yucesan, Suleyman Mete, Faruk Serin, Erkan Celik, Muhammet Gul

Subject: Computer Science And Mathematics, Computer Science Keywords: MCDM; BWM, interval type-2 fuzzy sets; TOPSIS; green supplier selection, plastic injection molding

Online: 31 December 2018 (11:00:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0140.v1

Adsorption of 2-(Hexadecanoylamino)Acetic Acid Onto the Surface of Smithsonite: Mechanism and Flotation Performance

Bin Luo, Junbo Liu, Quanjun Liu, Chao Song , Li Yu , Shimei Li , Hao Lai

Subject: Chemistry And Materials Science, Chemical Engineering Keywords: Smithsonite; Flotation; 2-(Hexadecanoylamino)acetic acid; Collector; Adsorption

Online: 6 November 2018 (11:59:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1655.v1

Advancements in Synthetic Generation for Contactless Palmprint Biometrics Using StyleGan2-ADA and StyleGAN3

A. M. Mahmud Chowdhury, Md Jahangir Alam Khondkar, Masudul Haider Imtiaz

Subject: Engineering, Electrical And Electronic Engineering Keywords: Palm print synthesis; Style-GAN-2-ADA; StyleGAN3; SIFT

Online: 21 December 2023 (14:04:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0689.v1

Effect of Total Starch and Resistant Starch in Commercial Extruded Dog Foods on Gastric Emptying in Non-Racing Sled Dogs

Taylor L. Richards, Alexandra Rankovic, John P. Cant, Anna K. Shoveller, Jennifer L. Adolphe, Dan Ramdath, Adronie Verbrugghe

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: canine, carbohydrates, grain-free, pet food, pharmacokinetic mathematical modelling, acetaminophen tracking.

Online: 30 July 2021 (09:29:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.1199.v2

Alpha Synuclein Toxicity and Non-motor Parkinson’s

Gabriella M. Mazzotta, Carmela Conte

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: alpha synuclein; Parkinson’ s disease; non-motor symptoms; early diagnosis

Online: 25 June 2024 (13:03:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0684.v1

Potential and Limits of the Synergy Between Cheiloscopy and Rugoscopy in Forensic Odontology

Andrea Trizzino, Davide Albano, Emanuele di vita, Fabio M Sciarra, Simone Vintrici, Lorenzo Reali, Enzo Cumbo, Giuseppa Bilello, Stefania Zerbo, Antonella Argo, Pietro Messina, Giuseppe Alessandro Scardina

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Cheiloscopy; Rugoscopy, Forensic dentistry; Sex

Online: 11 June 2024 (05:50:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0166.v1

Phonon Dispersion Curves of Silver (Ag) and Gold (Au): Application of Density Functional Theory and Inter – Atomic Force Constant

Omamoke Enaroseha, Obed Oyibo, Isioma Isioma M. EZEH, Damaris OSIGA – AIBANGBEE

Subject: Physical Sciences, Condensed Matter Physics Keywords: phonon; quantum expresso; Eigen – value; silver (Ag); gold (Au)

Online: 4 July 2023 (08:50:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1102.v1

Relationship Between Perception of Quality of Life and Nutri-tional Status of Mothers Caring For Childrew With Type 1 Diabetes Mellitus

Maria de Nazareth de Lima Carneiro, Arthur Andrade da Fonseca, Rachel Coelho Ripardo, Layla Sandia Cezário Alves, Manuela Maria de lima Carvalhal, Daniela Lopes Gomes

Subject: Public Health And Healthcare, Other Keywords: Quality of life; Health of caregivers; Nutritional status; type 1 diabetes

Online: 17 April 2024 (15:04:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints202402.1417.v1

Harnessing the Synergy of SGLT2 Inhibitors and Continuous Ketone Monitoring (CKM) in Managing Heart Failure Among Patients with Type 1 Diabetes

Nicola Tecce, Giorgio De Alteriis, Giulia de Alteriis, Ludovica Verde, Mario Felice Tecce, Annamaria Colao, Giovanna Muscogiuri

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: heart failure; type 1 diabetes; diabetic cardiomyopathy; hospitalization; HFpEF; HFrEF; SGLT2-i; sodium-glucose cotransporter-2 inhibitors; diabetic ketoacidosis; epidemiologic studies; patient education; continuous monitoring of ketone levels; ketonemia

Online: 26 February 2024 (11:54:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1317.v1

Gas Temperature Distribution in the Combustion Chamber of a GTM400 Mod Turbojet Engine Powered by Jet A-1 Fuel and Hydrogen

Łukasz Brodzik

Subject: Physical Sciences, Thermodynamics Keywords: turbojet engine; hydrogen combustion process; combustion chamber

Online: 18 January 2024 (03:29:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.2109.v1

Theoretical Study on the Structures and Stabilities of CunZn3O3 (N = 1 – 4) Clusters: Sequential Doping of Zn3O3 Cluster with Cu Atoms

Zhi-Wei Tao, Han-Yi Zou, Hong-Hui Li, Bin Wang, Wen-Jie Chen

Subject: Chemistry And Materials Science, Theoretical Chemistry Keywords: Copper-doped zinc oxide clusters; Density functional theory; Structural evolution; Reactivity

Online: 27 December 2023 (11:52:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202304.1028.v1

Evaluation of DNA Methylation Profiles of LINE-1, Alu and Ribosomal DNA Repeats in Human Cell Lines Exposed to Radiofrequency Radiation

Francesco Ravaioli, Maria Giulia Bacalini, Cristina Giuliani, Camilla Pellegrini, Chiara D'Silva, Sara De Fanti, Chiara Pirazzini, Gianfranco Giorgi, Brunella Del Re

Subject: Biology And Life Sciences, Life Sciences Keywords: Radiofrequency electromagnetic field; DNA methylation; Neuroblastoma; LINE-1; Alu; ribosomal DNA

Online: 27 April 2023 (04:12:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0128.v1

Epidemiological Description and Molecular Characterization of Intrafamily Transmission of Human T-Lymphotropic Virus Type 1 in an Endemic Region of Brazil

Cássia Pereira, Samir Mansour Moraes Casseb, Akim F.S. Nobre, Maria N. L. Reis, Carlos A. Costa, Louise S. C. Covre, Maisa S. Sousa

Subject: Biology And Life Sciences, Virology Keywords: HTLV; Amazon; Phylogeny

Online: 7 February 2023 (10:47:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0322.v1

Transporter Associated with Antigen Processing 1 (TAP1) as a Potential Biomarker for Breast, Lung, Liver and Ovarian Cancer using Health Informatics

Anika Tabassum, Md. Nazmus Samdani, Tarak Chandra Dhali, Rahat Alam, Foysal Ahammad, Abdus Samad, Tomasz M. Karpiński

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: TAP1; transcriptional expression; methylation analysis; survival analysis; co-expression; pathway analysis; health informatics

Online: 14 August 2020 (11:17:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0334.v1

Identification of Novel Inhibitors of Pteridine Reductase 1 in Trypanosoma brucei via Computational Structure-Based Approaches and In Vitro Inhibition Assays

Magambo Phillip Kimuda, Dustin Laming, Heinrich C. Hoppe, Özlem Tastan Bishop

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: human African trypanosomiasis; pteridine reductase 1; PTR1; DHFR; antifolates; anti-trypanosomal agents; molecular dynamics; dynamic residue network analysis; binding free energy; isobologram assay

Online: 14 November 2018 (10:39:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.2211.v1

Protein Disulfide Isomerase 4 is an Essential Regulator of Endothelial Function and Survival

Shuhan Bu, Aman Singh, Hien C. Nguyen, Bharatsinai Peddi, Kriti Bhatt, Naresh Ravendranathan, Jefferson C. Frisbee, Krishna K. Singh

Subject: Biology And Life Sciences, Life Sciences Keywords: MicroRNA; PDIA‐4; Autophagy; Apoptosis; Endothelial‐to‐mesenchymal transition; Endothelial function; and Cardiovascular diseases

Online: 28 December 2023 (16:01:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0604.v1

Isolated Neutropenia/Benign Ethnic Neutropenia: A Common Clinical and Laboratory Finding in Southern and Southwestern Saudi Arabia

Zuhier A. Awan, Saeed M. Al Amoudi, Muhammad Saboor, Husain Y. Alkhaldy

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: isolated neutropenia; benign ethnic neutropenia; reference intervals; Saudi Arabia

Online: 24 December 2020 (07:54:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.1224.v1

Translation, Cultural Adaptation of the Portuguese Provider Attitudes toward Cardiac Rehabilitation and Referral (PACRR-P) Scale and Assessment of its’ Measurement Properties

Mayara Moura Alves da Cruz, Luiz Carlos Marques Vanderlei, Carolina Takarashi, Maria Julia Lopez Laurino, Murilo Reis Alves da Cruz, Sherry L Grace, Gabriela L M Ghisi

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Attitudes; Cardiac rehabilitation; Health knowledge; Physician’ s practice patterns; Practice; Questionnaires

Online: 16 September 2024 (12:29:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1305.v1

Comorbidity Burden among Adults with Symptomatic COVID-19 Illness: A Cross-Sectional Study

Mini M. Jose, Juan Feng, Bushra Manakkat, Hoang Nguyen, Josie Tombrella, Patricia Savard, Hanaa S. Sallam, Hani Serag

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: COVID-19 positive adults; Charlson Comorbidity Index; Comorbidity burden and COVID-19; Depression and COVID-19; Comorbidities and COVID-19; Social determinants of COVID-19

Online: 19 August 2024 (10:05:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1265.v1

The Influence of Gender on the Psychiatric Comorbidity of Treated Danish Patients With and Without Alcoholism

Elizabeth C Penick, Waheeda A. Hossain, Wendy Madarasz, Ann M Manzardo, Joachim Knop, Erik L Mortensen, William F Gabrielli

Subject: Public Health And Healthcare, Health Policy And Services Keywords: Alcohol use disorder; Gender; Psychiatric comorbidity

Online: 19 April 2024 (09:56:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0981.v1

Prevalence, Characteristics, and Distribution of Human Papillomavirus According to Age and HIV Status in Women of Eastern Cape Province, South Africa

Zizipho Z. A. Mbulawa, Sinazo Kondlo, Sinalo Toni, Lindiwe M Faye, Charles B Businge

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: human papillomavirus; human immunodeficiency virus; age; women

Online: 12 September 2024 (11:36:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0894.v1

Guided Transformation of Abandoned Hydrocarbon Fields into Heat Storage Solutions Using Enhanced MCDA-AHP Geostatical Based Method, Hungarian Case Study

Hawkar Ali Abdulhaq, János Geiger, István Vass, Tivadar M. Tóth, Tamás Medgyes, János Szanyi

Subject: Environmental And Earth Sciences, Other Keywords: ; geothermal energy; Aquifer Thermal Energy Storage (ATES); underground heat storage; hydrocarbon fields; Multi-Criteria Decision Analysis (MCDA); data modeling ;

Online: 13 June 2024 (05:55:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0505.v1

The Detection of Vaccine Virus and Protection of a Modified Live, Intranasal, Tri-Valent Vaccine in Neonatal, Colostrum-Fed Calves with an Experimental Bovine Respiratory Syncytial Virus Challenge

Stephanie Perkins-Oines, Nirosh D Senevirathne, Greta M Krafsur, Karim Abdelsalam, David G. Renter, Brent Meyer, Christopher CL Chase

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Bovine respiratory syncytial virus, bovine herpesvirus, vaccine virus detection, neonatal calves, maternal antibody, intranasal tri-valent vaccine, virulent challenge, pulmonary lesions, serum neutral

Online: 8 May 2024 (16:09:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.0310.v1

Dimerization and Oligomerization of Alkenes Catalyzed with Transition Metal Complexes: Catalytic Systems and Reaction Mechanisms

Lyudmila V. Parfenova, Almira Kh. Bikmeeva, Pavel V. Kovyazin, Leonard M. Khalilov

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: dimerization; oligomerization; transition metal catalysis; metal hydrides; reaction mechanisms

Online: 6 December 2023 (07:53:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints201804.0123.v1

Environmental Lead Exposure and Adult Literacy in Myanmar: An Exploratory Study of Potential Associations at the Township Level

Robert C. MacTavish, Liam W. Remillard, Colleen M. Davison

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: lead exposure; adult literacy; global health; environmental health; Myanmar

Online: 10 April 2018 (09:51:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0218.v1

Dunkl Generalization of Phillips Operators and Approximation in Weighted Spaces

M. Mursaleen, Md Nasiruzzaman, Adem Kilicman, Siti Hasana Sapar

Subject: Computer Science And Mathematics, Analysis Keywords: Szász operator; dunkl analogue; generalization of exponential function; korovkin type theorem; modulus of continuity; order of convergence

Online: 12 March 2020 (14:28:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0134.v1

Dunkl generalization of Phillips operators and approximation in weighted spaces

M. Mursaleen, Md Nasiruzzaman, Adem Kilicman, Siti Hasana Sapar

Subject: Computer Science And Mathematics, Analysis Keywords: Szasz operator; Dunkl analogue; generalization of exponential function; Korovkin type theorem; modulus of continuity; order of convergence.

Online: 10 December 2019 (14:58:47 CET)

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Working Paper ARTICLE

Within the Lack of Chest COVID-19 X-ray Dataset: A Novel Detection Model Based on GAN and Deep Transfer Learning

Mohamed Loey, Florentin Smarandache, Nour Eldeen M. Khalifa

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: 2019 novel coronavirus; COVID-19; SARS-CoV-2; Deep Transfer Learning; Convolutional Neural Network; Machine Learning; GAN

Online: 7 April 2020 (10:59:04 CEST)

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The coronavirus (covid-19) pandemic is putting healthcare systems across the world under unprecedented and increasing pressure according to the World Health Organization (WHO). With the advances in computer algorithms and especially Artificial Intelligence, the detection of this type of virus in the early stages will help in fast recovery and help in releasing the pressure off healthcare systems. In this paper, a GAN with deep transfer learning for coronavirus detection in chest x-ray images is presented. The lack of benchmark datasets for covid-19 especially in chest x-rays images is the main motivation of this research. The main idea is to collect all the possible images for covid-19 that exists until the writing of this research and use the GAN network to generate more images to help in the detection of the virus from the available x-rays images with the highest accuracy possible. The dataset used in this research was collected from different sources and it is available for researchers to download and use it. The number of images in the collected dataset is 307 images for four different types of classes. The classes are the covid-19, normal, pneumonia bacterial, and pneumonia virus. The dataset is divided into 90% for the GAN and the training and the validation phase, while 10% used in the testing phase. The GAN helps in generating more images from the original dataset to be 30 times larger than the originally collected dataset. The GAN also help in overcoming the overfitting problem and made the proposed model more robust. Three deep transfer models are selected in this research for investigation. The models are the Alexnet, Googlenet, and Restnet18. Those models are selected based on their small number of layers on their architectures, which will reflect in reducing the complexity of the models and the consumed memory and time. Using a combination of GAN and deep transfer models prove it is efficiency according to validation, testing accuracy, and performance measurements such as precision, recall, and F1 score. Three case scenarios are tested through the paper, the first scenario which includes 4 classes from the dataset, while the second scenario includes 3 classes and the third scenario includes 2 classes. All the scenarios include the covid-19 class as it is the main target of this research to be detected. In the first scenario, the Googlenet is selected to be the main deep transfer model as it achieves 80.6% in testing accuracy. In the second scenario, the Alexnet is selected to be the main deep transfer model as it achieves 85.2% in testing accuracy, while in the third scenario which includes 2 classes(covid-19, and normal), Googlenet is selected to be the main deep transfer model as it achieves 100% in testing accuracy and 99.9% in the validation accuracy. All the performance measurement strengthen the obtained results through the research. Finally, this research may be considered one of the first trails to use GAN and deep transfer models together to help in detecting coronaviruses (covid-19) within the absence of a benchmark dataset around the world, especially in x-rays chest images.

Preprint BRIEF REPORT | doi:10.20944/preprints202005.0084.v1

Nsp7 and Spike Glycoprotein of SARS-CoV-2 Are Envisaged as Potential Targets of Vitamin D and Ivermectin

Jhimli Dasgupta, Udayaditya Sen, Abhisek Bakshi, Abhijit Dasgupta, Krishnendu Manna, Chinmay Saha, Rajat K. De, Satinath Mukhopadhyay, Nitai P. Bhattacharyya

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; Vitamin D; Ivermectin; RNA-dependent-RNA polymerase; Spike glycoprotein; Knowledge based docking

Online: 5 May 2020 (15:18:30 CEST)

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COVID-19 has emerged as deadly pandemic worldwide with no vaccine or suitable antiviral drugs to prevent or cure the disease. Because of the time-consuming process to develop new vaccines or antiviral agents, there has been a growing interest in repurposing some existing drugs to combat SARS-CoV-2. Vitamin D is known to be protective against acute respiratory distress syndrome (ARDS), pneumonia and cytokine storm. Recently it has been used as a repurposed drug for the treatment of H5N1 virus-induced lung injury. Circumstantial evidences indicate that people with low level of vitamin D are more susceptible to SARS-CoV-2. Although, vitamin D was suggested to interfere with viral replication, its interaction with any SARS-CoV-2 protein is unexplored yet. Beside this, ivermectin, a well-known anti-parasitic agent, exhibits potent anti-viral activities in vitro against viruses such as HIV-1 and dengue. Very recently, ivermectin has been found to reduce viral load of SARS-CoV-2 in vitro. We have analyzed available structures of SARS-CoV-2 proteins to identify probable binding partner(s) of vitamin D and ivermectin through knowledge-based docking studies and figured out possible implication of their binding in SARS-CoV-2 infection. Our observations suggest that the non-structural protein nsp7 possesses a potential site to house 25-hydroxyvitamin D3 (VDY) or the active form of Vitamin D, calcitrol. Binding of vitamin D with nsp7 likely to hamper the formation of nsp7-nsp8 complex which is required to bind with RNA dependent RNA polymerase (RdRP), nsp12 for optimal function. On the other hand, potential binding site of ivermectin has been identified in the S2 subunit of trimeric spike(S) glycoprotein of SARS-CoV-2. We propose that deeply inserted mode of ivermectin binding at three inter-subunit junctions may restrict large scale conformational changes of S2 helices which is necessary for efficient fusion of viral and host membrane. Our study, therefore, opens up avenues for further investigations to consider vitamin D and ivermectin as potential drugs against SARS-CoV-2.

Preprint ARTICLE | doi:10.20944/preprints201612.0121.v1

Antibacterial Activity of Ethanolic Extract of Cinnamon Bark and Honey and Their Combination Effects Against Acne Causing Bacteria

Elin Julianti, Kasturi K. Rajah, Irda Fidrianny

Subject: Medicine And Pharmacology, Dermatology Keywords: antibacterial activity, cinnamon, honey, checkerboards method, synergistic activity

Online: 23 December 2016 (18:37:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.0902.v1

Mucosal Metabolomic Signatures in Chronic Colitis: Novel Insights into the Pathophysiology of Inflammatory Bowel Disease

Nathan Calzadilla, Aisha Qazi, Anchal Sharma, Kai Mongan, Shane Comiskey, Jahnavi Manne, Alvin G. Youkhana, Sonam Khanna, Seema Saksena, Pradeep K. Dudeja, Waddah A. Alrefai, Ravinder K. Gill

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: chronic colitis; mucosal inflammation; host-microbe interactions; mucosal metabolomics

Online: 13 June 2023 (08:39:45 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints201702.0018.v1

Mastery Learning Strategy and Learning Retention: Effects on Senior Secondary School Students’ Achievement in Physical Geography in Ganye Educational Zone, Nigeria

Jacob Filgona, Joel Filgona, Linus, K. Sababa

Subject: Social Sciences, Education Keywords: mastery learning strategy; learning retention; achievement; physical geography; conventional method

Online: 5 February 2017 (10:01:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.2103.v1

Mosquito Salivary Antigens and their Relationship to Dengue and P. vivax Malaria

McKenna M. Howell, Olayinka Olajiga, Jenny C. Cardenas, Claudia A. Parada-Higuera, Maria U. Gonzales-Pabon, Lady Y. Gutierrez-Silva, Lucy Jaimes-Villamizar, Brett M. Werner, Jeffrey G. SHAFFER, Jennifer A. Manuzak, Berlin Londono-Renteria

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Aedes; dengue; Anopheles; biomarkers.; mosquito saliva

Online: 1 November 2023 (03:12:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.1373.v1

Endoscopic Management of Post-Esophagectomy Delayed-Gastric-Conduit-Emptying (DGCE): Results from a Cohort Study in a Tertiary Referral Center with Comparison between Procedures

Giuseppe Dell’Anna, Francesco Vito Mandarino, Jacopo Fanizza, Ernesto Fasulo, Alberto Barchi, Rukaia Barà, Edoardo Vespa, Edi Viale, Francesco Azzolini, Lorella Fanti, Silvia Battaglia, Francesco Puccetti, Andrea Cossu, Ugo Elmore, Lorenzo Fuccio, Vito Annese, Alberto Malesci, Riccardo Rosati, Silvio Danese

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: delayed gastric conduit emptying; esophagectomy; endoscopic pneumatic dilation; botulinum toxin ;

Online: 20 September 2024 (03:26:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0334.v1

Enhancing the assessment of Cleaner Production Practices for Sustainable Development: The Five Sectors Sustainability Model Applied to Water and Wastewater Treatment Companies

Biagio F. Giannetti, Fábio Sevegnani, Roberto R. M. García, Feni Agostinho, Cecilia M V B Almeida, Luca Coscieme, Gengyuan Liu, Ginevra Virginia Lombardi

Subject: Engineering, Control And Systems Engineering Keywords: Sustainability model; SDGs; Clean water; Drinking water; Water security.

Online: 24 January 2022 (02:08:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0308.v1

Pharmacoinformatics and Molecular Dynamic Simulation Studies Reveal Potential Inhibitors of SARS-CoV-2 Main Protease 3CL^pro

Mubarak A. Alamri, Muhammad Tahir ul Qamar, Safar M. Alqahtani

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: SARS-CoV-2; COVID-19; 3CL protease; molecular docking; molecular dynamics and simulations

Online: 23 February 2020 (02:17:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0305.v1

Multi-Method Determination of Antioxidant Capacity, Phytochemical and Biological Investigation of Four Different Solvent Extractives of Leucophyllum frutescens (cenizo)

Imtiaz Ahmad, Saeed Ahmad, Huma Rao, Umer Shaukat, Muhammad Nadeem Shahzad, M. Sajid-ur- Rehman, Abdul Basit, M. Adeel Arshad, Bilal Ahmad

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Leucophyllum frutescens; Total Phenolic Contents (TPC); Total Flavonoid Content (TFC); Total Antioxidant Activity (TAA); DPPH; CUPRAC; FRAP; gas chromatography-mass spectrometry (GC-MS)

Online: 10 November 2020 (12:00:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints201706.0015.v1

Gibberellic Acid Signaling Is Required to Induce Flowering of Chrysanthemum Grown under Both Short and Long Days

Bin Dong, Ye Deng, Haibin Wang, Ri Gao, Githeng’u K. Stephen, Sumei Chen, Fadi Chen, Jiafu Jiang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: gibberellin; photoperiod; mutant; floral induction; flowering time

Online: 2 June 2017 (07:45:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0871.v1

Implants Placed with a Ring Technique Using Inlay and Onlay Block Xenografts in the Mandible of Rabbits

Naoki Kaneko, Samuel Porfirio Xavier, Kenzo Morinaga, Daniele Botticelli, Erick Ricardo Silva, Yasushi Nakajima, Shunsuke Baba

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: animal study; bone healing; histology; lateral augmentation; bone transplantation; biomaterial; bone defect

Online: 14 November 2023 (11:16:45 CET)

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Background: Xenogenous bone has been proposed as an alternative to overcome the disadvantages of autogenous grafting. The aim of the present study was to study bone dynamics at inlay and onlay xenografts used for bone augmentation applying a ring technique. Methods: The bone at the lateral surface of the mandibular angle of 12 adult male New Zealand White rabbits was exposed bilaterally. The cortical layer received multiple perforations at one side of the mandible and a xenograft block of collagenated cancellous equine bone, 7 mm in diameter and 3 mm in width, was fixed on the prepared surface using an implant (onlay group). On the opposite side, a defect 7 mm in diameter and 3 mm in depth was prepared, the xenograft block was adapted to the defect and fixed with an implant (inlay group). Results: After ten weeks of healing, in the onlay grafts, new bone was mainly formed on the trabeculae surface, reaching in some specimens the most coronal regions of the block. In the inlay grafts, new bone was found arranged on the trabecular surfaces but also occupying the spaces among the trabeculae. The entrance of the defect was often found close at the top of the block by newly formed bone. A higher percentage of new bone was found in the inlay (19.0 ±9.3%) compared to the onlay (10.4 ±7.4%) groups (p=0.031). The mean gain in osseointegration at the implant in relation to the base of the original 3 mm deep defect was 0.95 ±1.05% at the onlay group and 0.78 ±0.71% at the inlay group (p=0.603). Conclusion: The inlay grafts exhibited a higher new bone percentage than the onlay grafts possibly due to the defect conformation that presented more sources for bone formation. The trabecular conformation and the composition of the grafts made possible the expression of the osteoconductive properties of the material used. This resulted, in several specimens, in growth of bone on the graft trabeculae toward the most superior regions in both groups, and in the closure of the coronal entrance of the defects in the inlay group.

Preprint ARTICLE | doi:10.20944/preprints202103.0693.v1

2La Paracentric Chromosomal Inversion and Overexpressed Metabolic Genes Enhance Thermotolerance and Pyrethroid Resistance in the Major Malaria Vector Anopheles gambiae

Sulaiman S. Ibrahim, Muhammad M. Mukhtar, Abdullahi Muhammad, Charles S. Wondji

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: malaria; Anopheles; coluzzii; gambiae; 2La; chromosomal; inversion; thermotolerance; permethrin; resistance

Online: 29 March 2021 (13:05:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1112.v1

Cellular Immunity of SARS-CoV-2 in the Borriana COVID-19 Cohort: A Nested Case-Control Study

Salvador Domenèch-Montoliu, Joan Puig-Barberà, Maria Rosario Pac-Sa, Alejandro Orrico-Sanchez, Lorna Gómez-Lanas, Diego Sala-Trull, Carmen Domènech-León, Alba Del Rio-González, Manuel Sanchez-Urbano, Paloma Satorres-Martinez, Laura Aparisi-Esteve, Gema Badenes-Marques, Roser Blasco-Gari, Juan Casanova-Suarez, Maria Gil-Fortuño, Noelia Hernández-Pérez, David Jovani-Sales, Laura López-Diago, Cristina Notari-Rodríguez, Oscar Pérez-Olaso, María Angeles Romeu-Garcia, Raquel Ruíz-Puig, Alberto Arnedo-Pena

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; SARS-CoV-2 infection; cellular immunity; T cells; CD4+; CD8+; humoral immunity; Anti-S antibodies Anti-N antibodies; nested case-control; associated factors

Online: 20 February 2024 (09:01:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202209.0288.v1

Use of Human Lung Tissue Models for Screening of Drugs Against SARS-CoV-2 Infection

Alexander J McAuley, Petrus Jansen van Vuren, Muzaffar-Ur-Rehman Mohammed, Faheem Faheem, Sarah Goldie, Shane Riddell, Nathan J Gödde, Ian K Styles, Matthew P Bruce, Simran Chahal, Stephanie Keating, Kim R Blasdell, Mary Tachedjian, Carmel M O'Brien, Nagendrakumar Balasubramanian Singanallur, John Noel Viana, Aditya V Vashi, Carl M Kirkpatrick, Christopher A MacRaild, Rohan M Shah, Elizabeth Vincan, Eugene Athan, Darren J Creek, Natalie L Trevaskis, Sankaranarayanan Murugesan, Anupama Kumar, Seshadri S Vasan

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; Therapeutics; Drug Repurposing; 3D Tissue Models

Online: 20 September 2022 (03:24:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201612.0092.v1

Estimating Density and Temperature Dependence of Juvenile Vital Rates Using a Hidden Markov Model

Robert M. McElderry

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Anaea aidea; caterpillar demography; multi-state mark-recapture; state-space model; stage-structured matrix

Online: 18 December 2016 (09:33:13 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202311.1910.v1

Epitope Mapping of an Anti-Ferret Podoplanin Monoclonal Antibody using the PA Tag-Substituted Analysis

Yu Isoda, Mika K Kaneko, Tomohiro Tanaka, Hiroyuki Suzuki, Yukinari Kato

Subject: Medicine And Pharmacology, Other Keywords: ferret podoplanin; monoclonal antibody; epitope; PA scanning

Online: 29 November 2023 (16:08:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1348.v1

A Cancer-Specific Monoclonal Antibody against Podocalyxin Exerted Antitumor Activities in Pancreatic Cancer Xenografts

Hiroyuki Suzuki, Tomokazu Ohishi, Tomohiro Tanaka, Mika K. Kaneko, Yukinari Kato

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: podocalyxin; PODXL; cancer-specific monoclonal antibody; defucosylated antibody; pancreatic cancer

Online: 20 October 2023 (11:46:59 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202310.0453.v1

PMab-301: An Anti-Giraffe Podoplanin Monoclonal Antibody for Immunohistochemistry

Tsunenori Ouchida, Tomohiro Tanaka, Hiroyuki Suzuki, Mika K Kaneko, Yukinari Kato

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: podoplanin; PDPN; giraffe; Immunohistochemistry

Online: 9 October 2023 (04:24:50 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202308.0725.v1

Establishment of Anti-dog PD-L1 Monoclonal Antibodies for Immunohistochemistry

Tsunenori Ouchida, Hiroyuki Suzuki, Tomohiro Tanaka, Mika K Kaneko, Yukinari Kato

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: dPD-L1; monoclonal antibody; peptide immunization; immunohistochemistry

Online: 9 August 2023 (07:11:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0900.v1

Antitumor Activities against Breast Cancers by an Afucosylated Anti-HER2 Monoclonal Antibody H₂Mab-77-mG_2a-f

Tomohiro Tanaka, Hiroyuki Suzuki, Tomokazu Ohishi, Mika K. Kaneko, Yukinari Kato

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: HER2; monoclonal antibody; ADCC; CDC; antitumor activity

Online: 13 July 2023 (09:23:17 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202307.0721.v1

Development of Highly Sensitive Anti-Mouse Epidermal Growth Factor Receptor 2 Monoclonal Antibodies for Flow Cytometry

Tsunenori Ouchida, Hiroyuki Suzuki, Tomohiro Tanaka, Mika K Kaneko, Yukinari Kato

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: mouse HER2; monoclonal antibody; cell-based Immunization and screening; CBIS

Online: 12 July 2023 (03:20:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0399.v1

A Novel Anti-CD44 Variant 9 Monoclonal Antibody C₄₄Mab-1 was Developed for Immunohistochemical Analyses Against Colorectal Cancers

Mayuki Tawara, Hiroyuki Suzuki, Tomohiro Tanaka, Mika K Kaneko, Yukinari Kato

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: CD44; CD44v9; monoclonal antibody; colorectal cancer

Online: 22 March 2023 (14:21:41 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202303.0309.v1

Identification of the Binding Epitope of an Anti-Mouse CCR6 Monoclonal Antibody (C6Mab-13) Using 1×Alanine Scanning

Tomohiro Tanaka, Mayuki Tawara, Hiroyuki Suzuki, Mika K. Kaneko, Yukinari Kato

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: mouse CCR6; monoclonal antibody; epitope; ELISA; SPR

Online: 16 March 2023 (14:13:28 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202303.0181.v1

Establishment of a Novel Anti-Human CCR6 Monoclonal Antibody C₆Mab-19 with the High Binding Affinity in Flow Cytometry

Tomohiro Tanaka, Kaishi Kitamura, Hiroyuki Suzuki, Mika K. Kaneko, Yukinari Kato

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: CCR6; monoclonal antibody; peptide immunization; flow cytometry; immunohistochemistry

Online: 9 March 2023 (13:45:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0437.v1

Development of a Novel Anti-CD44 Variant 7/8 Monoclonal Antibody C44Mab-34 for Multiple Applications against Oral Carcinomas

Hiroyuki Suzuki, Kazuki Ozawa, Tomohiro Tanaka, Mika K. Kaneko, Yukinari Kato

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: CD44; CD44 variant 7/8; monoclonal antibody; flow cytometry; immunohistochemistry

Online: 27 February 2023 (04:13:02 CET)

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Preprint REVIEW | doi:10.20944/preprints202202.0242.v1

Current Targeted Therapy for Metastatic Colorectal Cancer

Tomokazu Ohishi, Mika K. Kaneko, Yukihiro Yoshida, Yukinari Kato, Manabu Kawada

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Colorectal cancer; Targeted therapy; Clinical trial

Online: 21 February 2022 (03:05:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0988.v1

Machine Learning Model Trained with Finite Element Modeling Can Predict the Risk of Osteoarthritis: Data from the Osteoarthritis Initiative

Mika E. Mononen, Mimmi K. Liukkonen, Mikael J. Turunen

Subject: Physical Sciences, Applied Physics Keywords: knee; cartilage; finite element analysis; machine learning; osteoarthritis

Online: 12 September 2024 (12:26:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0038.v1

Antibiotic Resistance Genes Detection in Several Local Cyanobacteria Isolates

Harith K. Buniya, Nuha Mohammed, Dhyauldeen Aftan Al-Hayani

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Algae; Antibiotic resistance gene; ARG; Blue-green algae; Cyanophyta

Online: 2 September 2024 (08:53:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1895.v1

Epitope Mapping of an Anti-mouse CCR8 Monoclonal Antibody C₈Mab-2 Using Flow Cytometry

Hiyori Kobayashi, Hiroyuki Suzuki, Tomohiro Tanaka, Mika K. Kaneko, Yukinari Kato

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: mouse CCR8; monoclonal antibody; epitope mapping; alanine scanning; flow cytometry

Online: 26 January 2024 (08:35:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202304.1191.v1

Deposition of Nanocrystalline Multilayer Graphene Using Pulsed Laser Deposition

Yuxuan Wang, Bin Zou, Bruno Rente, Neil Alford, Peter K Petrov

Subject: Chemistry And Materials Science, Nanotechnology Keywords: Graphene; Pulsed Laser deposition; nanocrystallization

Online: 29 April 2023 (03:00:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0400.v1

Orai3 Regulates Pancreatic Cancer Metastasis by Encoding a Functional Store Operated Calcium Entry Channel

Samriddhi Arora, Jyoti Tanwar, Nutan Sharma, Suman Saurav, Rajender K. Motiani

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Orai3; Store Operated Calcium entry; Pancreatic Cancer; Metastasis

Online: 27 October 2021 (11:16:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1960.v1

The Diagnosis, Treatment, and Prevention of Glaucoma – An Update

Karen Allison, Kevin Andrew Morabito, Margaret M. DeAngelis, Deepkumar Patel

Subject: Medicine And Pharmacology, Ophthalmology Keywords: Glaucoma; epidemiology of glaucoma; open angle glaucoma; blindness; disparities in glaucoma treatment and diagnosis

Online: 28 December 2023 (02:26:28 CET)

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Working Paper ARTICLE

The Transcription Factor OVOL2 Represses ID2 and Drives Differentiation of Trophoblast Stem Cells and Placental Development in Mice

Mariyan J. Jeyarajah, Gargi Jaju Bhattad, Dendra M. Hillier, Stephen J. Renaud

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: embryogenesis; blastocyst; trophoblast; stem cell; differentiation; placenta; Ovo-like 2

Online: 8 March 2020 (04:11:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0152.v1

Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Massimo Sangiorgi, Mariangela Valentina Puci, Allegra Rosa Martelli, Teresa Messina, Paolo Frigatti, Maria Pia Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco Michelino Fiore, Armado Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, Diego Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Pietro Modugno, Maurizio Maiorano, Umberto Marcello Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, Giovanni Maria Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munaó, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio Stefano Tolva, Ilenia D'Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D'Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio Massimo Oddi, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: chronic limb-threatening ischemia; outcome; sex; age; limb salvage

Online: 8 December 2022 (09:39:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.1966.v1

Rasagiline Confers Neuroprotection to PC12 Cell Cultures Exposed to Oxygen-Glucose Deprivation/Reoxygenation Insult by Activating the Akt/Nrf2 Redox-Signaling Pathway and by Decreasing the Nuclear Translocation of Glyceraldehyde-3-Phosphate Dehydroge

Shimon Lecht, Adi Lahiani, Michal Klazas, Majdi Saleem Naamneh, Limor Rubin, Jiayi Dong, Wenhua Zheng, Philip Lazarovici

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Akt; cell death; GAPDH; ischemia-like insult; neuroprotection; Nrf2; phosphorylation; Rasagiline; ROS; PC 12 neuronal model; α-synuclein; Parkinson’s disease; stroke

Online: 1 July 2024 (08:40:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0419.v1

Achieving Zero Efficiency Droop in Highly Efficient N-Polar AlGaN Tunnel Junction-based 254 nm DUV LED

Khalid Ayub, Banaras Khan, M. Nawz Sharif, M. Ajmal Khan, Hideki Hirayama

Subject: Physical Sciences, Applied Physics Keywords: DUV; AlGaN; N-Polar; IQE

Online: 4 August 2023 (11:20:58 CEST)

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Deep ultraviolet (DUV) light emitting diode (LED) at emission wavelength of 254 nm is inevitable to replace the conventional toxic mercury UV Lamp as demanded by Minamata Convention of 2020. Both the conventional DUV LEDs (C-LED) and tunnel junction (TJ)-based UVC LEDs are suffering from high operating voltages, low hole injection efficiency and efficiency droops. Therefore, p-AlGaN and n-AlGaN layers-based TJ is one of the most promising parts of optical devices and has been widely utilized as carrier tunneling in DUV LEDs to mitigate both the contact resistance for Ohmic contact and low hole injection efficicny at 254 nm emission. Here an approach is presented to electrically manipulate the quantum tunneling probability by exploiting the transported carriers at the interface of n-AlGaN/p-AlGaN TJ with moderate Si and Mg-doping levels and optimized thickness. As a result, the Augur recomination rate was sucesfully suppressed and quite high radiative recombination rates were achived in the 254nm TJ-based DUV LEDs, which is attributed the improved holes injection toward the MQWs when compared to C-LED. The internal-quantum efficiency (IQE) of approximately ~ 88% in the TJ-based LED with zero efficiency droop is achived, which is 1.3 times greater than the IQE of approximately ~ 66% in the C-LED with efficiency droop of 53%. Based on our known knowledge, this is the highest reported IQE (88%) at emission wavelength of 254 nm in the AlGaN TJ-based LED with efficiency droop of 0%. It was found that the light output powers (LOP) of TJ-LED increases linearly under the varying current density, whereas in the case of C-LED the LOP changes nonlinearly under varying current density. This is attributed to the lower Augure recombination rate in the MQWs of TJ-based DUV LED. The operating voltages were remarkable reduced from 20 V to 5.4 V under 200 mA operation, which is attributed to the thickness and doping optimization in TJ and better selection of realively lower Al-content in the contact-layer. The demonstrated TJ-based DUV LEDs opens the door to epitaxial growth of high-performance UV emitters in MOCVD and MBE for a plethora of biomedical applications.

Preprint ARTICLE | doi:10.20944/preprints202408.1495.v1

Aperiodic Tiling for Enhancing Security in Wireless Sensor Networks

Ayaz Khan, Gabriel Macias-Villegas, Habib M. Ammari

Subject: Computer Science And Mathematics, Computer Networks And Communications Keywords: wireless sensor networks; clone attacks; intrusion detection; security topology

Online: 21 August 2024 (02:47:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.1028.v1

Valorization of Peach By-Products: Utilizing Them as Valuable Resources in a Circular Economy Model

Nikoletta Solomakou, Aikaterini M. Drosaki, Kyriakos Kaderides, Ioannis Mourtzinos, Athanasia M. Goula

Subject: Engineering, Other Keywords: bioactive compounds; extraction; peach; peel; pomace; seeds

Online: 14 January 2024 (16:07:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0309.v1

Entropy and Entropic Forces to Model Biological Fluids

Rafael M. Gutierrez, George T. Shubeita, Chandrashekhar U. Murade, Jianfeng Guo

Subject: Physical Sciences, Acoustics Keywords: entropic forces; biological fluids; crowding; polymer’s configurations

Online: 13 July 2021 (14:16:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0288.v1

Spatial Distribution and Environmental Significance of Phosphorus Fractions in River Sediments and Its Influencing Factor from Hongze and Tiaoxi Watersheds, Eastern China

Ja Bawk Marip, Xuyin Yuan, Hai Zhu, Isaac Kwesi Nooni, Solomon O.Y. Amankwah, Nana Agyemang Prempeh, Eyram Norgbey, Taitiya K. Yuguda, Zaw Myo Khaing

Subject: Engineering, Civil Engineering Keywords: Phosphorus fractions; Phosphorus; Sediment; Tiaoxi; Hongze; Watershed

Online: 24 June 2020 (08:54:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1364.v1

Surface Characteristics of Ti6Al7Nb Alloy after Sandblasting and Anodic Oxidation Process for Biomedical Applications

Karolina Goldsztajn, Maciej Krzywiecki, Lucyna Grządziel, Marcin Godzierz, Anna Taratuta, Ada Orłowska, Marcin Basiaga, Wojciech Kajzer, Marcin Dyner, Janusz Szewczenko

Subject: Chemistry And Materials Science, Biomaterials Keywords: sandblasting; anodic oxidation; Ti6Al7Nb titanium alloy

Online: 22 April 2024 (10:16:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2027.v1

Performance and Metabolic Evaluation in Primiparous Beef Cows under Grazing with Different Ages at Breeding

Mariana N. F. Vital, Juarez J. da Silva Paiva, Robert T. Paixão, Marcos I. Marcondes, Jarbas M. M. da Silva Júnior, Márcia Oliveira Franco, Edenio Detmann, Cláudia B. Sampaio

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Bos indicus; Body condition; Primiparous cows; Reproductive efficiency; Supplementation

Online: 30 May 2023 (03:24:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0335.v1

Three-Dimensional Printing Using Recycled High-Density Polyethylene: Technological Challenges and Future Directions for Construction

Faham Tahmasebinia, Marjo Niemelä, Sanee M. Ebrahimzadeh Sepasgozar, Tin Yiu Lai, Winson Su, Kakarla Raghava Reddy, Sara Shirowzhan, Samad M. E. Sepasgozar, Fernando Alonso Marroquin

Subject: Engineering, Architecture, Building And Construction Keywords: 3D printing (3DP), Construction processes, Architectural design, Concrete Engineering, Numerical Modelling, Arch-Roof, High-density polyethylene (HDPE), Additive manufacturing (AM), Computer-aided design (CAD), Manufacture, Design, Sustainability

Online: 14 November 2018 (10:39:43 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202005.0262.v1

C1-INH and the Contact System in COVID-19-Associated Coagulopathy

Timothy M. Thomson, Emily Toscano, Ernesto Casis, Rosanna Paciucci

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: COVID-19; coagulopathy; C1-INH

Online: 16 May 2020 (04:19:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0535.v1

Generalization Ability of Bagging and Boosting Type Deep Learning Models in Evapotranspiration Estimation

Manoranjan Kumar, Yash Agrawal, Sirisha Adamala, Pushpanjali ., Subbarao A.V.M, V.K. Singh, Ankur Srivastava

Subject: Engineering, Marine Engineering Keywords: Ensembled machine learning, Reference evapotranspiration, Decision tree, XGBoost

Online: 5 July 2024 (12:09:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.1673.v1

Collagen and Its Derivatives Serving Biomedical Purposes: A Review

Hanna Wosicka-Frąckowiak, Kornelia Poniedziałek, Stanisław Woźny, Mateusz Kuprianowicz, Martyna Nyga, Barbara Jadach, Bartłomiej Milanowski

Subject: Chemistry And Materials Science, Biomaterials Keywords: biomaterial; biocompatibility; collagen; derivatives of collagen; medical applications; tissue engineering and regeneration; drug delivery systems; bioinks for 3D bioprinting

Online: 23 August 2024 (00:15:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1075.v1

Evaluation of Antimicrobial Activity by Marine Nocardiopsis dassonvillei against Foodborne Listeria monocytogenes and Shiga Toxin-Producing Escherichia coli

Siyanda S. Ngema, Solomuzi H. Khumalo, Michael C. Ojo, Ofentse J. Pooe, Tsolanku Sidney Maliehe, Albertus K. Basson, Evelyn Madoroba

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Nocardiopsis dassonvillei SOD(B)ST2SA2; Antibacterial activity; Molecular docking; Listeria monocytogenes

Online: 15 August 2023 (11:45:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0431.v2

Prediction of Postoperative Outcomes Following Hip Fracture Surgery: Independent Validation and Recalibration of the Nottingham Hip Fracture Score

William J. Doherty, Thomas A. Stubbs, Andrew Chaplin, Mike R. Reed, Avan A. Sayer, Miles D. Witham, Antony K. Sorial

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Hip fracture; Casemix; Validation; Discrimination; Risk score; Calibration

Online: 9 July 2020 (17:23:04 CEST)

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Objectives Independent validation of risk scores after hip fracture is uncommon, particularly for evaluation of outcomes other than death. We aimed to assess the Nottingham Hip Fracture Score (NHFS) for prediction of mortality, physical function, length of stay and postoperative complications. Design Analysis of routinely collected prospective data partly collected by follow-up interviews. Setting and Participants Consecutive hip fracture patients were identified from the Northumbria hip fracture database between 2014-2018. Patients were excluded if they were not surgically managed or if scores for predictive variables were missing. Methods C-statistics were calculated to test the discriminant ability of the NHFS, Abbreviated Mental Test Score (AMTS), and ASA grade for in-hospital, 30- and 120-day mortality, functional independence at discharge, 30-days and 120-days, length of stay, and postoperative complications. Results We analysed data from 3208 individuals, mean age 82.6 (SD 8.6). 2192 (70.9%) were female. 194 (6.3%) died during the first 30-days, 1686 (54.5%) were discharged to their own home, 211 (6.8%) had no mobility at 120-days, 141 (4.6%) experienced a postoperative complication. The median length of stay was 18 days (IQR 8-28). For mortality, c-statistics for the NHFS ranged from 0.68-0.69, similar to ASA and AMTS. For postoperative mobility, the c-statistics for the NHFS ranged from 0.74-0.83, similar to AMTS (0.61-0.82) and better than the ASA grade (0.68-0.71). Length of stay was significantly correlated with each score (p<0.001 by Jonckheere-Terpstra test); NHFS and AMTS showed inverted U-shaped relationships with length of stay. For postoperative complications, c-statistics for NHFS (0.54-0.59) were similar to ASA grade (0.53-0.61) and AMTS (0.50-0.58). Conclusions and Implications The NHFS performed consistently well in predicting functional outcomes, moderately in predicting mortality, but less well in predicting length of stay and complications. There remains room for improvement by adding further predictors such as measures of physical performance in future analyses.

Preprint ARTICLE | doi:10.20944/preprints202409.0647.v1

Consciousness = Metaphysics + Physics + Biology

Alan M Laibelman

Subject: Arts And Humanities, Philosophy Keywords: consciousness; self-consciousness; cosmogony; cosmology

Online: 9 September 2024 (11:28:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.2387.v1

Chemical Diversity of Ketosteroids as Potential Therapeutic Agents

Valery M Dembitsky

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: ; ketosteroids; microorganisms; fungal endophytes; invertebrates; plant; anticancer activity ;

Online: 30 July 2024 (10:26:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2098.v1

Arabic X (Formerly Twitter) Sentiment Analysis Using Skip Grams Method

Rasha M. AlEidan

Subject: Computer Science And Mathematics, Computer Science Keywords: Sentiment; Arabic; machine learning; Text analysis; Tweet; Social Network

Online: 26 July 2024 (09:09:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1791.v1

Lessons from Eukaryl tRNA: Mammals Are Not Fungi

Alan M Laibelman

Subject: Biology And Life Sciences, Other Keywords: mammals; tRNA; comparative genomics; model organisms

Online: 23 July 2024 (13:46:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.1544.v1

Why Honey Bees Are Dying: A Forgotten Cause

Jacques J. M. van Alphen

Subject: Biology And Life Sciences, Insect Science Keywords: natural selection, genetic variation, population structure, Varroa resistance, behaviour

Online: 25 October 2023 (05:18:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0563.v2

Binary Particle Swarm Optimization Algorithm for Kidney Exchanges Acceleration using Parallel MATLAB

Wael M. F. Abdel-Rehim

Subject: Computer Science And Mathematics, Data Structures, Algorithms And Complexity Keywords: kidney exchange; Particle Swarm; Meta-heuristics; Optimization

Online: 14 May 2021 (11:03:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0283.v1

Effects of Manufacturing Variation in Electronic Cigarette Coil Resistance and E-liquid Characteristics on Coil Lifetime and Aerosol Generation

Qutaiba M. Saleh, Edward C. Hensel, Nathan C. Eddingsaas, Risa J. Robinson

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: aerosol generation; e-cigarette; coil resistance; e-liquid; manufacturing variation

Online: 11 February 2021 (11:50:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints201711.0147.v1

A Comparative Analysis of the Proteins and Lipids in Breast, Leg, and Thigh Meats of a Commercial Domesticated Turkey

W. Keith Ray, Sherry B. Hildreth, Judith M. Jervis, Richard F. Helm

Subject: Biology And Life Sciences, Food Science And Technology Keywords: glycolysis; lipidome; meat; mitochondria; oxidation; proteome; turkey

Online: 23 November 2017 (03:11:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1040.v1

The Impact of Using Internal Reinforcement or/and External Strengthening around the Openings for Hybrid Steel-BFRP Reinforced Concrete Beams

Sameh Yehia, Bader Faihan, Arafa M. A. Ibrahim

Subject: Engineering, Civil Engineering Keywords: Beams with openings; Basalt fiber-reinforced polymer (BFRP); Stiffness, Ductility; Energy; Hybrid Reinforcement; Strengthening

Online: 15 August 2023 (02:44:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1101.v1

Importance of Technology in the Combined Interventions of Cognitive Stimulation and Physical Activity in the Elderly: A Systematic Review Study

Rute Ribeiro Rocha, Sara Margarida Fernandes, Isabel M. Santos

Subject: Public Health And Healthcare, Other Keywords: Cognitive stimulation; physical activity; combined interventions; older adults; new technologies; exergaming; e-mental health

Online: 16 May 2023 (05:27:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0254.v1

In Silico Prediction of siRNA Ionizable-Lipid Nanoparticles in vivo Efficacy: Machine Learning Modeling Based on Formulation and Molecular Descriptors

Abdelkader A Metwally, Amira A Nayel, Rania M Hathout

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: siRNA; ionizable lipids; nanoparticles; in vivo; QSAR; machine learning

Online: 11 August 2021 (11:12:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0161.v2

Mathematical Modelling to Study the Horizontal Transfer of Antimicrobial Resistance Genes in Bacteria: Current State of the Field and Recommendations

Quentin J. Leclerc, Jodi A. Lindsay, Gwenan M. Knight

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: antimicrobial resistance; horizontal gene transfer; mathematical modelling; epidemiology; microbiology

Online: 6 May 2019 (10:59:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0061.v1

Influence of Sheep Breeds on Feed Intake, Growth Performance, Digestibility and Nitrogen Utilization

Ahmed Mohamed El-Waziry, Gamaleldin M. Mostafa Suliman, Abdullah Nasser Al-Owaimer

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Sheep breeds; Awassi; Najdi; Harri; Growing; Digestibility; Nitrogen retention

Online: 2 July 2021 (14:19:29 CEST)

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Working Paper ARTICLE

A Novel Threat-Abatement Framework Confirms an Urgent Need to Limit Habitat Loss and Improve Management of Invasive Species and Inappropriate Fire Regimes for Australia’s Threatened Species

Stephen G. Kearney, James E. M. Watson, April E. Reside, Diana O. Fisher, Martine Maron, Tim S. Doherty, Sarah M. Legge, John C. Z. Woinarski, Stephen T. Garnett, Brendan A. Wintle, Euan G. Ritchie, Don A. Driscoll, David Lindenmayer, Vanessa M. Adams, Michelle S. Ward, Josie Carwardine

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Biodiversity; Conservation; Extinction; Threat management; Habitat retention; Protected Areas.

Online: 19 October 2020 (11:08:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1991.v1

The Spatiotemporal Links between Towns and Countryside through the Sale and Consumption of Rural Products: The Case of Oporto and Lisbon Cities

Carlos Ribeiro, Cláudia M. Viana, Inês Girão, Elisabete Figueiredo, Jorge Rocha

Subject: Social Sciences, Geography, Planning And Development Keywords: Specialized store; Gourmet store; Agri-food products; Urban-rural linkage; Local production; Territorial cohesion; Spatial analysis; Geographic Information Systems

Online: 28 June 2023 (10:07:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0135.v1

Increased Levels of Plasma Tumor Necrosis Factor-α Mediate Schizophrenia Symptom Dimensions and Neurocognitive Impairments and Are Inversely Associated with Natural IgM and Paraoxonase 1 Activity

Michael Maes, Sunee Sirivichayakul, Andressa Keiko Matsumoto, Annabel Maes, Ana Paula Michelin, Laura de Oliveira Semeão, João Victor de Lima Pedrão, Estefania G. Moreira, Decio S. Barbosa, Michel Geffard, Andre F. Carvalho, Buranee Kanchanatawan

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: cytokines, neuro-immune, inflammation, antioxidants, oxidative stress, paraoxonase 1

Online: 12 November 2019 (17:02:22 CET)

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