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Preprint ARTICLE | doi:10.20944/preprints202304.0285.v1

Variation in Relative Abundance of Small Mammal species Caught in Two Different Ecosystems And Implicated in the Spread of Emerging Pathogens, in Mali

Abdoulaye Kassoum Koné, Georges Diatta, Doumbo Safiatou Niare, Solimane Ag Atteynine, Maïmouna Coulibaly, Adama Zan Diarra, Issaka Sagara, Abdoulaye Djimdé, Ogobara Doumbo, Mahamadou Ali Thera

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Small mammals; Reservoirs; Pathogenic agents; Transmission; Low diversity; Relative abundance; Mali

Online: 13 April 2023 (03:21:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0283.v1

Research and Implementation of Low-Power Anomaly Recogni-Tion Method for Intelligent Manhole Covers

Jiahu Guo, Kai Wang, Jianquan Sun, Youcheng Jia

Subject: Engineering, Electrical And Electronic Engineering Keywords: low power consumption; Internet of Things; Intelligent manhole cover; attitude solving

Online: 13 April 2023 (03:12:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0123.v2

Deciphering Pain in Vulnerable People with Chronic Conditions

Charlotte Faurie, Demi Cheng, Claire Duflos, Liset E.M. Elstgeest, Rosanna Ferreira, Hein Raat, Verushka Valsecchi, Alberto Pilotto, Graham Baker, Marta María Pisano-Gónzalez, Yves-Marie Pers

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: chronic pain; patient education; vulnerable populations; low income; quality of life

Online: 14 March 2023 (01:42:07 CET)

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Preprint REVIEW | doi:10.20944/preprints202302.0307.v1

Electronic Modulation and Structural Engineering of Carbon-Based Anodes for Low-Temperature Lithium-Ion Batteries: A Review

Jiaxun Sun, Lingqian Ye, Xinran Zhao, Peipei Zhang, Jun Yang

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: carbon; anode; lithium-ion batteries; electronic modulation; structural engineering; low temperature

Online: 17 February 2023 (08:49:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0348.v1

Complication and Infection Risk using Bone Substitute Materials to Treat Long Bone Defects in Geriatric Patients– An Observational Study

Jonas Pawelke, Vithusha Vinayahalingam, Thaqif El Khassawna, Christian Heiss, Larissa Eckl, Gero Knapp

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: trauma; geriatric; osteoporosis; humerus; radius; tibia; bone substitute; low impact; falls

Online: 19 January 2023 (08:52:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0311.v1

Complication and Infection Risk Using Bone Substitute Materials to Treat Long Bone Defects in Geriatric Patients– An Observational Study

Jonas Pawelke, Vithusha Vinayahalingam, Thaqif El Khassawna, Christian Heiss, Larissa Eckl, Gero Knapp

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: trauma; geriatric; osteoporosis; humerus; radius; tibia; bone substitute; low impact; falls

Online: 17 January 2023 (11:08:55 CET)

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Preprint REVIEW | doi:10.20944/preprints202205.0113.v1

The Development of iDPC-STEM and Its Application in Electron Beam Sensitive Materials

Hongyi Wang, Linlin Liu, Jiaxing Wang, Chen Li, Jixiang Hou, Kun Zheng

Subject: Physical Sciences, Condensed Matter Physics Keywords: electron beam sensitive materials; electron microscopic characterization; low dose; iDPC-STEM

Online: 9 May 2022 (09:56:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0064.v1

First-Principles Study of the Electronic Structure of LLM-105 Crystal and (101) Plane Under High Pressure

Gang He, Wen Kun Zhu, Zhi Qiang Qiao, Zheng Guo Chen, Jun Wen

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: low-Miller-index; High pressure; (101) plane; DFT calculation; LLM-105

Online: 7 April 2022 (14:27:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0101.v1

Mixed Solvents in Multi-Layer Ceramic Capacitors (MLCC) Elec-Tronic Paste and Their Effects on the Properties of Organic Vehicle

Ruolong Gan, Junrong Li, Xiuhua Cao, Jun Huang, Liying Qian

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: electronic paste; organic vehicle; mixed-solvents; solubility parameter; low residual rate

Online: 7 December 2021 (11:46:21 CET)

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Working Paper COMMUNICATION

Mid-Low Resolution Remote Sensing Ship Detection Using Super-Resolved Feature Representation

Shitian He, Huanxin Zou, Yingqian Wang, Runlin Li, Fei Cheng, Xu Cao

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: Ship detection; image super-resolution; mid-low resolution remote sensing images

Online: 16 August 2021 (12:51:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0457.v1

Transition Modeling for Low Pressure Turbines Using Computational Fluid Dynamics Driven Machine Learning

Harshal D. Akolekar, Fabian Waschkowski, Yaomin Zhao, Roberto Pacciani, Richard D. Sandberg

Subject: Engineering, Automotive Engineering Keywords: Machine Learning; Multi-objective optimization; Low Pressure Turbine; Transition; Turbulence Modeling

Online: 17 June 2021 (10:39:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0630.v1

Microfabrication With Very Low-Average Power of Green Light to Produce PDMS Microchips

Lucero M. Hernandez -Cedillo, Francisco G. Vázquez-Cuevas, Rafael Quintero-Torres, Jose L. Aragón, Miguel Angel Ocampo Mortera, Cesar L. Ordóñez-Romero, Jorge Luis Domínguez-Juárez

Subject: Physical Sciences, Optics And Photonics Keywords: Microfabrication; polymeric microchip; laser ablation; PDMS devices; low-cost fabrication tool.

Online: 24 December 2020 (14:06:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0470.v1

Linear and Nonlinear Dynamic Methods towards Investigating Proprioception Impairment in Non-specific Low Back Pain Patients

Seyed Mohammadreza Shokouhyan, Mehrdad Davoudi, Maryam Hoviattalab, Mohsen Abedi, Soha Bervis, Mohamad Parnianpour, Simon Brumagne, Kinda Khalaf

Subject: Engineering, Bioengineering Keywords: Posture control; low back pain; COP; proprioception; Recurrence Quantification Analysis; Vibrator

Online: 20 July 2020 (11:39:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0158.v1

Using a Network of Locally Developed Low Cost Particulate Matter Sensors for Land Use Regression Modeling of PM2.5 in Urban Uganda

Eric S. Coker, Ssematimba Joel, Engineer Bainomugisha

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: land use regression; low-cost sensors; machine learning; particulate matter; Africa

Online: 14 June 2020 (03:11:17 CEST)

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Background: There are major air pollution monitoring gaps in sub-Saharan Africa. Developing capacity in the region to conduct air monitoring in the region can help estimate exposure to air pollution for epidemiology research. The purpose of our study is to develop a land use regression (LUR) model using low-cost air quality sensors developed by a research group in Uganda (AirQo). Methods: Using these low-cost sensors, we collected continuous measurements of fine particulate matter (PM2.5) between May 1, 2019 and February 29, 2020 at 22 monitoring sites across urban municipalities of Uganda. We compared average monthly PM2.5 concentrations from the AirQo sensors with measurements from a BAM-1020 reference monitor operated at the US Embassy in Kampala. Monthly PM2.5 concentrations were used for LUR modeling. We used eight Machine Learning (ML) algorithms and ensemble modeling; using 10-fold cross validation and root mean squared error (RMSE) to evaluate model performance. Results: Monthly PM2.5 concentration was 60.2 µg/m³ (IQR: 45.4-73.0 µg/m³; median= 57.5 µg/m³). For the ML LUR models, RMSE values ranged between 5.43 µg/m³- 15.43 µg/m³ and explained between 28% and 92% of monthly PM2.5 variability. Generalized additive models explained the largest amount of PM2.5 variability (R²=0.92) and produced the lowest RMSE (5.43 µg/m³) in the held-out test set. The most important predictors of monthly PM2.5 concentrations included monthly precipitation, major roadway density, population density, latitude, greenness, and percentage of households using solid fuels. Conclusion: To our knowledge, ours is the first study to model the spatial distribution of urban air pollution in sub-Saharan Africa using air monitors developed from the region itself. Non-parametric ML for LUR modeling performed with high accuracy for prediction of monthly PM2.5 levels. Our analysis suggests that locally produced low-cost air quality sensors can help build capacity to conduct air pollution epidemiology research in the region.

Preprint ARTICLE | doi:10.20944/preprints202005.0503.v1

A Logarithmic Turbulent Heat Transfer Model in Applications with Liquid Metals for PR = 0.01-0.025

Roberto Da Vià, Sandro Manservisi, Valentina Giovacchini

Subject: Engineering, Energy And Fuel Technology Keywords: Turbulent heat transfer; Low-Prandtl fluidS; RANS modeling; Logarithmic turbulence model

Online: 31 May 2020 (20:27:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0211.v1

Development and Validation of a Risk Score to Predict Low Birthweight Using Characteristics of the Mother: A Prospective Cohort Study

Hamid Y. Hassen, Bilal S. Endris, Meselech A. Roro, Seifu H. Gebreyesus, Jean-Pierre Van Geertruyden

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: prediction; model; risk score; low birthweight; pregnant women; decision curve analysis

Online: 13 April 2020 (11:15:32 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints201910.0248.v1

The Study of Viability of Vibrio cholerae Strains in Low Ionic Strength Aquatic Environment

Subha Sankar Paul, Eizo Takahashi, Goutam Chowdhury, Shin-ichi Miyoshi, Asish K. Mukhopadhyay, Shanta Dutta, Keinosuke Okamoto

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Vibrio cholerae; cholera toxin gene; low ionic strength aquatic solution; viability

Online: 22 October 2019 (04:00:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0275.v1

Life Cycle Assessment of Solar Façade Concepts Based on Transparent Insulation Materials

Karel Struhala, Miroslav Čekon, Richard Slávik

Subject: Engineering, Civil Engineering Keywords: building; environmental impacts; façade; life-cycle assessment; transparent insulation; low-emissivity

Online: 12 November 2018 (09:36:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints201809.0583.v1

Photocatalytic Degradation of Estriol Using Iron-Doped TiO2 under High and Low UV-Irradiation

Irwing M. Ramírez-Sánchez, Erick R. Bandala

Subject: Chemistry And Materials Science, Nanotechnology Keywords: iron-doped TiO2; photocatalytic activity; low UV-irradiation; hydroxyl radical; estriol

Online: 29 September 2018 (05:48:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0385.v2

Study of the behavior pattern, carbon reduction effect and business costs of electric motorcycles on island

Shyang-Chyuan Fang

Subject: Engineering, Transportation Science And Technology Keywords: low carbon island; electric motorcycles; green transport; battery exchange; carbon emissions

Online: 5 September 2018 (16:23:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0242.v1

Tunable Metal-Organic Frameworks for Heat Transformation Applications

Somboon Chaemchuen, Xuan Xiao, Nikom Klomkliang, Mekhman S. Yusubov, Francis Verpoort

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Metal-organic frameworks; heat transformation; low temperature heat; adsorbent; water adsorption.

Online: 13 July 2018 (15:32:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0278.v1

Parameter Identification of Low Frequency Oscillation Based on Fourier Synchrosqueezing Transform

wenbo wang, yunyu Jin, bin wang, qi di, min yu

Subject: Engineering, Electrical And Electronic Engineering Keywords: Fourier-based synchrosqueezing transform; low frequency oscillation; instantaneous parameters; damping ratio

Online: 18 June 2018 (16:07:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0438.v1

The Effect of C₂H₂/H₂ Gas Mixture Ratio in Direct Low-Temperature Vacuum Carburization

Yeongha Song, Jun-Ho Kim, Kyu-Sik Kim, Sunkwang Kim, Pung Keun Song

Subject: Chemistry And Materials Science, Surfaces, Coatings And Films Keywords: direct surface activation; low-temperature vacuum carburization; expanded austenite; supersaturation; acetylene

Online: 30 May 2018 (06:23:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0042.v1

Validity and Reliability of the Kinovea Program in Obtaining Angular and Distance Dimensions

Albert Puig-Diví, Josep Maria Padullés-Riu, Albert Busquets-Faciaben, Xavier Padullés-Chando, Carles Escalona-Marfil, Daniel Marcos-Ruiz

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: free software; human motion; Kinovea; low cost; reliability; validity; video analysis

Online: 9 October 2017 (05:07:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints201708.0032.v1

Qualitative Studies of Infant and Young Child Feeding in Lower-Income Countries: A Systematic Review and Synthesis of Dietary Patterns and Their Determinants

Alessandra N. Bazzano, Aiko Kaji, Erica Felker-Kantor, Kaitlin Storck Potts

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: qualitative research; infant feeding; complementary feeding; breast feeding; low income country

Online: 8 August 2017 (12:00:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201705.0188.v1

Application of a Composite Model in the Analysis of Creep Deformation at Low and Intermediate Temperatures

Xinjun Yang, Xiang Ling

Subject: Engineering, Mechanical Engineering Keywords: Creep; Composite constitutive model; θ projection method; low and intermediate temperature

Online: 25 May 2017 (17:35:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201704.0072.v1

Techno-Economic Analysis of Hydrokinetic Turbines

Anurag Kumar, R. P. Saini

Subject: Engineering, Mechanical Engineering Keywords: ultra-low head turbines; cost correlations; Darrieus; Savonius; small hydro energy

Online: 13 April 2017 (06:06:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1246.v1

Oxygen-Ozone and Porcine Collagen Injectable Therapies ImProve the Quality of Life in Low Back Pain Patients. Boosting Efficacy in Pain and Disability

Manuela De Pascalis, Susanna Mulas, Liliana Sgarbi

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Low back pain; oxygen-ozone therapy; Porcine collagen type 1; porcine collagen injection; Low back pain clinical management; combination therapy; Numerical Classification Scale; Roland Morris Questionnaire

Online: 16 September 2024 (14:07:17 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202005.0182.v1

Ribosomal Proteins Homologies and Methylation of Mitoribosome by Corona Virus Nsp9, Nsp10 and Previously Described Nsp13-16 Proteins Suggested Their Roles in the Inhibition of Host Protein Synthesis: Discovery of New Therapeutic Targets against Corona Virus Infections

Asit Kumar Chakraborty

Subject: Biology And Life Sciences, Virology Keywords: Coronavirus Nsp proteins; ribosomal proteins homology; inhibition of ribosome turn over; rRNA methyltransferase; protein synthesis inhibition; low ATP formation; blood clotting; low blood pressure and coma

Online: 10 May 2020 (18:14:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0622.v1

Deep Learning versus Spectral Techniques for Frequency Estimation of Single-Tones: Reduced Complexity for SDR and IoT Sensor Communications

Hind Almayyali, Zahir M. Hussain

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Frequency Estimation; Deep Learning (DL); Sensors; Internet of Things (IoT); Short Word-Length (SWL); Software-Defined Radio (SDR); Parallel-Computing FFT; Low-Power; Low-Cost; Biomedical Sensors.

Online: 26 February 2021 (15:22:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.1404.v1

The Impact of the Lighting Regimen and Feeding Program during Rearing on Hy-Line Brown Pullets at the End of Rearing and, During Early Lay

Wendy Isabelle Muir, Yeasmin Akter, Sebastian K.Y. Kho, Kenneth Bruerton, Peter John Groves

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: food restriction; reduced lighting; egg quality; egg production; body weight; feed intake; age of first egg; growth; photoperiod

Online: 18 September 2024 (12:43:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2452.v1

Heterozygous Smad4 Knock out Effect on Pancreatic and Body Weight Variation in F1 Population Using Mutant and Wild Type Collaborative Cross Mice

Osayd Zohud, Iqbal M. Lone, Kareem Midlej, Aysar Nashef, Imad Abu-Elnaaj, Fuad A. Iraqi

Subject: Biology And Life Sciences, Other Keywords: Smad4; pancreatic weight; genetic background; sex differences; Collaborative Cross; F1 mice; genetic modifiers; tumor suppressor gene

Online: 30 July 2024 (10:53:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1663.v1

A Hybrid Whale Optimization Algorithm for QoS-Aware Manufacturing Cloud Service Composition

Hong Jin, Cheng Jiang, Shengping Lv

Subject: Engineering, Mechanical Engineering Keywords: cloud manufacturing; quality of service; manufacturing cloud service composition; whale optimization algorithm; Lévy flight; adaptive crossover; adaptive weight

Online: 26 October 2023 (07:35:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1763.v1

Anti-Obesity Effects of Larval Powder of Steamed and Lyophilized Mature Silkworms in A Newly Designed Adult Mouse Model

Min Woo Kim, Yu-Jin Ham, Hyun-Bok Kim, Ji young Lee, Jung-Dae Lim, Hyun-Tai Lee

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: adipose tissue; appetite; body weight; Bombyx mori; high-fat diet; food intake; mature silkworm; normal diet; nutraceutical; obesity

Online: 27 September 2023 (03:08:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0949.v1

Analysis of the Influence of Calculation Parameters on the Design of the Gearbox of a High Power Wind Turbine

Francisco Rubio, Carlos Llopis-Albert, Ana M. Pedrosa

Subject: Engineering, Mechanical Engineering Keywords: wind turbine; gearbox; calculation parameters; tooth width; weight; modulus; allowable stress at surface pressure; allowable stress at bending

Online: 14 September 2023 (07:11:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.2143.v1

Predominant Maternal Risk Factors Increase the Prevalence of Caesarean Section Deliveries: A Cross-Sectional Study in a Reproductive-Aged Women Population

Eleni Pavlidou, Sousana K. Papadopoulou, Olga Alexatou, Evmorfia Psara, Dimitrios Papandreou, Maria Menzelou, Anastasia Sampani, Christina Tryfonos, Maria Spanoudaki, Gerasimos Tsourouflis, Gavriela Voulgaridou, Eleana Toli, Constantinos Giaginis

Subject: Public Health And Healthcare, Other Keywords: caesarean section; pre-pregnancy; overweigh; obesity; gestational weight gain; preterm birth; pregnancy complications; nutritional interventions; maternal risk factors

Online: 29 June 2023 (12:38:51 CEST)

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Background: There is an exponential increase in caesarean sections with epidemic proportions worldwide, which is considered as a serious public health issue that influences negatively both maternal and childhood health. Aims: This study aimed to evaluate the associations between pre-dominant maternal risk factors and the prevalence of caesarean section in a representative sample of women from Greece. Methods: This is a cross-sectional study conducted on 5182 healthy, re-productive-aged women from 11 geographically diverse Greek areas after applying specific inclu-sion and exclusion criteria. Statistical analysis was applied to evaluate the impact of maternal so-ciodemographic, anthropometric, lifestyle and perinatal factors in the risk of caesarean section de-liveries. Results: A high prevalence of 56.4% of caesarean section deliveries was recorded in the study population. The incidence of caesarean sections reached to 51.5% in private hospitals in which an increasing rate of 47.5% for planned caesarean sections were noticed. Older maternal age, pre-pregnancy overweight and obesity, excess gestational weight gain, high rates of preterm birth, better economic status, smoking habits, and private type of birth hospital were significantly related with enhanced risk of caesarean section, independently of multiple confounding factors. Conclu-sions: Our study revealed that caesarean section rates are continuously increase, while several maternal risk factors, including especially pre-pregnancy overweight/obesity and excess gestational weight gain, cumulatively raise its prevalence which further increase the risk for postnatal adverse outcomes for both the mothers and their children. Emergent public health policies and strategies should be promoted to confront the predominant maternal risk factors-related with caesarean sec-tion and inform future mothers how to be prevented from them by applying healthier nutritional and lifestyle habits and to select caesarean section only due to emergency medical reasons. Alarmingly enough, targeted nutritional intervention strategies are strongly recommended to ef-fectively reduce the prevalence of maternal pre-pregnancy overweight/obesity and the excess gestational weight gain, which in turn may minimize the risk of childhood overweight/obesity.

Preprint ARTICLE | doi:10.20944/preprints202303.0145.v1

Factors Affecting the Vitamin C Dose-Concentration Relationship: Implications for Global Vitamin C Dietary Recommendations

Anitra C. Carr, Jens Lykkesfeldt

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: vitamin C; ascorbic acid; vitamin C requirements; vitamin C recommendations; body weight; obesity; smoking; aging; socioeconomic status; NHANES

Online: 8 March 2023 (03:47:32 CET)

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Vitamin C status is known to be associated with several demographic and lifestyle factors. These include gender, age, ethnicity, pregnancy/lactation, body weight, smoking status and dietary habits. In the present study, our aim was to interrogate the National Health and Nutrition Examination Survey (NHANES) 2017-2018 datasets to assess the impact of these factors on vitamin C dose-concentration relationships to establish if there are higher requirements for vitamin C in certain subpopulations and the possible extent of these additional requirements. The relevant data were extracted from the NHANES 2017-2018 datasets, the final cohort of which comprised 2828 non-supplementing adult males and females (aged 18 – 80+ years) with both vitamin C serum concentrations and dietary intake data available. The data was subsequently stratified by gender, age tertiles (≤36, 37-58, ≥59 years), ethnicity (non-Hispanic white, non-Hispanic black, and total Hispanic), socioeconomic tertiles (poverty income ratios: >3.0, 1.36 – 3.0, ≤1.35), weight tertiles (≤72, 72-91, ≥91 kg), BMI tertiles (≤26, 26-32, ≥32 kg/m2) and smoking status. Sigmoidal (four parameter logistic) curves with asymmetrical 95% confidence intervals were fitted to the dose-concentration data. We found that males required vitamin C intakes ~1.2-fold higher than females to reach ‘adequate’ serum concentrations of 50 µmol/L. Males had both higher body weight and a higher prevalence of smoking than females. Smokers required vitamin C intakes ~2.0-fold higher than non-smokers to reach adequate vitamin C concentrations. Relative to adults in the lighter weight tertile, adults in the heaver weight tertile required ~2.0-fold higher dietary intakes of vitamin C to reach adequate serum concentrations. We did not observe any impact of ethnicity or socioeconomic status on the vitamin C dose-concentration relationship, and although no significant difference between younger and older adults was observed at vitamin C intakes > 75 mg/day, at intakes < 75 mg/day, older adults had an attenuated serum response to vitamin C intake. In conclusion, certain demographic and lifestyle factors, specifically gender, smoking and body weight, have a significant impact on vitamin C requirements. Overall, the data indicate that the general population must consume ~110 mg/day of vitamin C to attain adequate serum concentrations, smokers require ~165 mg/day relative to non-smokers, and heavier people (100+ kg) require ~155 mg/day to reach the same vitamin C concentrations. These findings have important implications for global vitamin C dietary recommendations.

Preprint COMMUNICATION | doi:10.20944/preprints202203.0203.v1

Estimation of Vitamin C Intake Requirements Based on Body Weight

Anitra C. Carr, Gladys Block, Jens Lykkesfeldt

Subject: Biology And Life Sciences, Food Science And Technology Keywords: vitamin C; ascorbate; obesity; body weight; vitamin C intake; plasma ascorbate concentrations; vitamin C requirements; dietary vitamin C

Online: 15 March 2022 (10:45:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0306.v1

Lifestyle Variations During and After the COVID-19 Pandemic: A Cross-Sectional Study of Dietary, Physical Activities and Weight Gain Among the Adult Population

Hanan Hammouri, Fidaa Almomani, Ruwa Abdel Muhsen, Aysha Abughazzi, Rawand Daghmash, Alaa Abudayah, Inas Hasan

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: COVID-19 Pandemic; Dietary patterns; BMI; Nutrition; Vitamins; Healthy Food; Dietary Supplements; Factor analyses; Internal Consistency; weight gain

Online: 17 November 2021 (12:09:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202106.0332.v1

Malnutrition in Infants Aged under 6 Months Attending Community Health Centres: A Cross Sectional Survey

Carlos S. Grijalva-Eternod, Emma Beaumont, Ritu Rana, Nahom Abate, Hatty Barthorp, Marie McGrath, Ayenew Negesse, Mubarek Abera, Alemseged Abdissa, Tsinuel Girma, Elizabeth Allen, Marko Kerac, Melkamu Berhane

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Anthropometric deficit; infants under 6 months; malnutrition; weight-for-age; the Composite Index of Anthropometric Failure; MAMI; Ethiopia

Online: 14 June 2021 (08:31:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.1006.v1

Discovery of A Novel Cyclopeptide as Tyrosinase Inhibitor for Skin Lightening

Huailong Chang, Kan Tao, Hu Huang, JinPing Jia, Shah Nawaz Khan, Jiahua Cui

Subject: Medicine And Pharmacology, Dermatology Keywords: Cyclopeptide; tyrosinase inhibitors; chemical synthesis; molecular docking; skin lightening; cosmetics

Online: 15 October 2024 (11:46:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202410.0936.v1

Aromatic Metal Corrosion Inhibitors

Jessica Roscher, Dan Liu, Xuan Xie, Rudolf Holze

Subject: Chemistry And Materials Science, Electrochemistry Keywords: Corrosion; soluble corrosion inhibitors; molecular inhibitors; aromatic inhibitors; substituent effects

Online: 11 October 2024 (13:24:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1911.v1

Uric Acid Transporter Gene SLC22A12 is a Chimera of Multiple Ancestral Genes

Kazuharu Misawa

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Uric acid transporter; Gout; Hyperuricemia; Gene fusion; Molecular Evolution; Mammal

Online: 24 September 2024 (11:56:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.2037.v1

How Helpful May Be a CRISPR/Cas-Based System for Food Traceability?

Silvia Farinati, Aurélien Devillars, Alessandro Vannozzi, Francesco Scariolo, Fabio Palumbo, Gianni Barcaccia

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Genome editing; New breeding techniques; Molecular traceability; CRISPR/Cas system

Online: 28 August 2024 (10:03:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.1390.v1

A Review of Molecular Dynamics Simulation of Different Ti-Al Based Alloys

Ningning Li, Zhenjie Hao, Lei Xu, Mingqi Tang, Leyu Wei, Shuai Li, Lifei Wang

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: Ti-Al based alloys; structural materials; molecular dynamics; material data

Online: 19 August 2024 (17:16:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0535.v1

Photocatalytic Degradation of Azo Dyes over Magnetite-Based Catalyst: Kinetic, Thermodynamic and Structure-Activity Studies

Jackson Anderson S. Ribeiro, Júlia F. Alves, Bruno César Barroso Salgado, Alcineia C. Oliveira, Rinaldo S. Araújo, Enrique Rodríguez-Castellón

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: heterogeneous photo-Fenton-like; magnetite; degradation; azo dyes; molecular effects

Online: 8 August 2024 (12:38:56 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202408.0313.v1

Mesofractal Modeling of Biosystems & Organic Spintronics

Widastra Hidajatullah Maksoed

Subject: Physical Sciences, Biophysics Keywords: meso fractals; molecular spintronics; optical engine; control system; [PI(D)]

Online: 6 August 2024 (06:32:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2136.v1

Quantification of Methane Hydration Energy Through Free Energy Perturbation Method

Faranak Hatami, Mousa Moradi

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Solvation free energies; Free Energy Perturbation; hydration; Molecular dynamics; LAMMPS

Online: 26 July 2024 (06:37:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1675.v1

Epidemiology of Brucella Species Circulating in Small Holder Dairy Cattle in Tanzania

Isaac Joseph Mengele, James M. Akoko, Gabriel Shirima, Shedrack Festo Bwatota, Shabani Kiyabo Motto, Luis Enrique Hernandez-Castro, Daniel Mushumbusi Komwihangilo, Eliamoni Lyatuu, Barend Mark de Clare Bronsvoort, Elizabeth Anne Jessie Cook

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: dairy cattle; brucellosis; qPCR; molecular prevalence; risk factors; Brucella; Tanzania

Online: 25 June 2024 (10:07:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0568.v1

Alternative Structure-Function Insight Into Angiotensin II Positions 3 and 4 Based on Investigations of Analogues Containing Unconventional Amino Acid Derivatives

Clovis Ryuichi Nakaie, Alexandre De Jesus Barros

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Angiotensin II; Conformational evaluation; Molecular Dynamics; Biological Activity; Yasara software

Online: 10 June 2024 (11:57:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1880.v1

Assessment of the Fungal Contaminants of Dried Fishes Sold in Open Markets in Awka, Nigeria

Uche Chukwurah, Chito Ekwealor, Nzube Ekpunobi

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Dried Fish; Molecular Identification; PCR; ; Aspergillus; Penicillium and Fusarium

Online: 29 May 2024 (06:35:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1295.v1

Affibody PET Imaging of HER2-Expressing Cancers as a Key to Guide HER2-Targeted Therapy

Nina Eissler, Renske Altena, Ali Alhuseinalkhudhur, Olga Bragina, Joachim Feldwisch, Guido Wuerth, Annika Loftenius, Nikolai Brun, Rimma Axelsson, Vladimir Tolmachev, Jens Sörensen, Fredrik Y Frejd

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: HER2; breast cancer; diagnostics; molecular imaging; Affibody molecules; clinical trials

Online: 19 April 2024 (15:08:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0321.v1

How to Improve Surveillance Program for Shiga Toxin-Producing E. coli (STEC): Gap Analysis and Pilot Study

Valerio Massimo Sora, Francesca Zaghen, Alfonso Zecconi

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: E. coli; STEC; epidemiology; surveillance; molecular biology; PCR; dairy; bovines.

Online: 3 April 2024 (16:33:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0302.v1

Effect of Nanohydroxyapatite on Silk Fibroin-Chitosan Interactions. Molecular Dynamics Study

Maciej Przybyłek, Anna Tuwalska, Damian Ledziński, Sandra Śmigiel, Alina Sionkowska, Iwona Białas, Piotr Bełdowski

Subject: Chemistry And Materials Science, Biomaterials Keywords: biomaterials; chitosan; silk fibroin; molecular dynamics; intermolecular interactions; hydrogen bonds

Online: 3 April 2024 (14:02:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1191.v1

Impact of Copolymer Architecture on Demicellization and Cargo Release via Head-to-Tail Depolymerization of Hydrophobic Moieties

Christos Gioldasis, Apostolos Gkamas, Costas Hristos Vlahos

Subject: Chemistry And Materials Science, Theoretical Chemistry Keywords: Molecular Dynamics; self-assembly; depolymerization; demicellization; cargo release.; spherical brushes

Online: 20 March 2024 (12:18:14 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0621.v1

Research Progress in Fuel Oil Production by Catalytic Pyrolysis Technologies of Waste Plastics

Liu An, Zonglan Kou, Renjie Li, Zhen Zhao

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: waste plastics; polyolefin; catalyst; thermal cracking; molecular sieve; fuel oil

Online: 11 March 2024 (13:28:39 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1436.v1

Novel Growth Network in Muscle Regeneration is Revealed by Molecular Acupuncture-like In Vivo Transfection

Ernő Zádor

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: skeletal muscle; regeneration; molecular acupuncture; SERCA; Ras; in vivo transfection

Online: 26 February 2024 (11:54:10 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202402.0107.v1

Exploring Natural Compounds for Cardiovascular Research: Myeloperoxidase Inhibition and Toxicity Prediction Studies

Ivan Vito Ferrari

Subject: Public Health And Healthcare, Other Keywords: cardiovascular research; myeloperoxidase; Astringin; pkCSM; Molecular Docking

Online: 2 February 2024 (04:54:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.2026.v1

Phosphorus Adsorbed by Hydrochloric Acid Desorption–Activated Red Mud Adsorbents: A Molecular Dynamics Study

Longjiang Li, Zhi wen Yang, Yueqin Qiu, Yalan Wang

Subject: Engineering, Mining And Mineral Processing Keywords: red mud; hydrochloric acid; desorption; density functional theory; molecular dynamics

Online: 29 January 2024 (12:33:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1369.v1

FlashPCR: Revolutionising qPCR by Accelerating Amplification through Low ∆T Protocols

Stephen Andrew Bustin, Sara Kirvell, Tania Nolan, Gregory L. Shipley

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Reverse transcription; qPCR; COVID-19; molecular diagnostics; point-of-care

Online: 18 January 2024 (12:01:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0588.v1

Phytoene Desaturase (Pds) Gene-Derived Markers Identify “A” and “B” Genomes in Banana (Musa spp.)

Fernanda dos Santos Nascimento, Marcelly Santana Mascarenhas, Samantha Costa Boaventura, Carla Catharina Hora Souza, Andresa Priscila de Souza Ramos, Anelita de Jesus Rocha, Julianna Matos da Silva Soares, Leandro Eugenio Cardamone Diniz, Tiago Antônio De Oliveira Mendes, Claudia Fortes Ferreira, Edson Perito Amorim

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Gene composition; phytoene desaturase; molecular marker; genetic improvement; Musa spp.

Online: 8 January 2024 (11:27:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0576.v1

Study on the Effects of Wettability and Pressure in Shale Matrix Nanopores Imbibition during Shut-in Process by Molecular Dynamics Simulations

Wen Jiang, Weifeng Lv, Ninghong Jia, Xiaoqing Lu, Lu Wang, Kai Wang, Yuhao Mei

Subject: Physical Sciences, Atomic And Molecular Physics Keywords: imbibition; shut-in pressure; wettability; micro-mechanism; molecular dynamics simulation

Online: 8 January 2024 (07:23:49 CET)

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Shut-in after fracturing is generally adopted for wells in shale oil reservoirs, and imbibition occurring in matrix nanopores has been proven as an effective way to improve recovery. In this research, the molecular dynamics (MD) simulation was used to investigate the effects of wettability and pressure on nanopores imbibition during shut-in for a typical shale reservoir Jimsar. The results indicate that the microscopic advancement mechanism of the imbibition front is the competitive adsorption between “interfacial water molecules” at the imbibition front and “adsorbed oil molecules” on the pore wall. The essence of spontaneous imbibition involves the adsorption and aggregation of water molecules onto the hydroxyl groups on the pore wall. The flow characteristics of shale oil suggest that the overall push of the injected water to the oil phase is the main reason for the displacement of adsorbed oil molecules. Thus, shale oil especially the heavy hydrocarbon component in the adsorbed layer tends to slip on the walls. However, the weak slip ability of heavy components on the wall surface is an important reason that restricts the displacement efficiency of shale oil during spontaneous imbibition. The effectiveness of spontaneous imbibition is strongly dependent on the hydrophilicity of the matrix pore's wall. The better hydrophilicity of the matrix pore's wall facilitates higher levels of adsorption and accumulation of water molecules on the pore wall and requires less time for “interfacial water molecules” to compete with adsorbed oil molecules. During the forced imbibition process, the pressure difference acts on both the bulk oil and the boundary adsorption oil, but mainly on the bulk oil, which leads to the occurrence of wetting hysteresis. Meanwhile, shale oil still existing in the pore always maintains a good stratified adsorption structure. Because of the wetting hysteresis phenomenon, as the pressure difference increases, the imbibition effect gradually increases, but the actual capillary pressure gradually decreases and there is a loss in the imbibition velocity relative to the theoretical value. Simultaneously, the decline in hydrophilicity further weakens the synergistic effect of pressure difference because of the more pronounced wetting hysteresis. Thus, selecting an appropriate well pressure enables cost savings and maximizes the utilization of the formation's natural power for EOR.

Preprint REVIEW | doi:10.20944/preprints202401.0454.v1

Recent Advances on Therapy of Slowing Progression of Dia-betic Kidney Disease

Na Wang, Chun Zhang

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: DKD; molecular mechanisms; ACEI/ARB; SGLT2i; NS-MRAs; GLP-1RAs

Online: 5 January 2024 (10:38:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0481.v1

Development of a Real-Time PCR Assay for Early Detection of the Eucalyptus Pathogen Quambalaria eucalypti

Roberto Faedda, Gabriela B. Silva

Subject: Biology And Life Sciences, Life Sciences Keywords: Quambalaria eucalypti; Quambalaria shoot blight; qPCR; diagnostics; molecular detection; Eucalyptus.

Online: 5 January 2024 (10:13:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.0701.v3

An In-Depth Insight into Clinical, Cellular and Molecular Factors in COVID19-Associated Cardiovascular Ailments for Identifying Novel Disease Biomarkers, Drug Targets and Clinical Management Strategies

Muneera Altaweel, Abdulmohsen AlMusaad, Gousay Alkhazmari, Hussain Alrowaily, Maram AlSubaiee, Mareyah Alshaikh Husain, Nouf Alomayrin, Rafyel Al Muaiweed, Norah Aleid, Abdulrahman A Alarfaj, Sarah AlMukhaylid, Zainab Albahrani, Aftab Ahmed Jalbani, Zafar Iqbal

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Cardiovascular diseases; COVID-19; pathophysiology; molecular pathogenesis; personalized cardiovascular medicine

Online: 20 December 2023 (10:57:30 CET)

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Background: COVID-19 was initially identified as a respiratory system disorder, but it has been discovered to interact with and influence the cardiovascular system. COVID-19-associated cardiovascular (CV) complications are common, resulting in high acute phase mortality and a large number of morbidities in the chronic phase, thus severely impacting patients' quality of life and health outcomes. Nevertheless, clinical, cellular, and molecular biological factors underlying the pathophysiology of cardiovascular complications associated with COVID-19 are poorly understood. Objective: This review investigates putative underlying clinical factors as well as cellular and molecular biological mechanisms by which COVID-19 leads to acute CV complications, including state-of-the-art genomic sequencing-based findings, assessing the long-term CV consequences of COVID-19, and aiming to shed light on developing strategies for differential diagnosis, risk prognostic stratification, prevention, and clinical management of CV sequlea in COVID-19 patients. Methods: For this purpose, a through review of literature and published data was carried out from first report of COVID-19 till October 2023 to find out a comprehensive account of clinical, cellular and molecular genetic factors underlying COVID-19-associated cardiovascular diseases. Results: We found that the relationship between COVID-19 and CV risk is complex and multifaceted. In addition to acute COVID-19 detertriuos effects, COVID-19 survivors may experience long-term CV effects. We provide a detailed account of the involvement of a large number of genomic alterations, microRNAs, and novel viral as well as host proteins in CVDs associated with COVID-19, which has helped identify some novel drug targets to treat COVID-19-related cardiovascular complications. Conclusions: The relationship between COVID-19 and CV risk is complex and multifaceted. While COVID-19 primarily affects the respiratory system, it can also significantly affect CV health. as compared to classical cardiovascular diseases, there are new clinical, cellular and molecular biological factors in CVDs related to COVID-19, that need specific diagnostic assays, prognostic stratification and treatment modules. Therefore, specail care is must taken to treat cardiovascular diseases associated with COVID-19.

Preprint REVIEW | doi:10.20944/preprints202312.1401.v1

Crafting Genetic Diversity: Unlocking the Potential of Protein Evolution

Vamsi Krishna Gali, Kang Lan Tee, Tuck Seng Wong

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Protein engineering; directed evolution; genetic diversity; random mutagenesis; molecular cloning

Online: 19 December 2023 (10:45:59 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.1355.v1

Molecular Characteristics of Tumor Cell: Recent Advances and Challenges

Abas Mahammed Abdi

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: ; cancer; NK cells; macrophages; T cells; immunotherapy; molecular characterization

Online: 21 November 2023 (15:27:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0114.v1

Identification of Aggregation Processes in Hexamethylenetetramine Aqueous Solutions: A Comprehensive Raman and Acoustic Spectroscopic Study Combined with Molecular Orbital Calculations

Stefanos Tsigoias, Michael G. Papanikolaou, Themistoklis A. Kabanos, Angelos G. Kalampounias

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: Raman; Ultrasonic relaxation spectroscopy; Molecular orbital calculations; Hexamethylenetetramine; Aggregation mechanism

Online: 2 November 2023 (08:17:34 CET)

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Raman scattering has been employed to study in detail the concentration dependence of the vibrational modes for the hexamethylenetetramine (HMTA) aqueous solutions. The formation of protonated and/or aggregated species has been clarified by comparing the experimental with the theoretically predicted vibrational spectra by means of quantum mechanical calculations. The analysis has shown that the vibrational modes of the solutions arise from a contribution of the vibrational modes of the HMTA self-aggregates and hetero-aggregates of HMTA with water molecules that are formed in the low- and intermediate-concentration region, respectively. The protonation of HMTA is ruled out due to the large differences between the experimental and the theoretically calculated spectra of the protonated molecules of HTMA in the fingerprint region. In the low-concentration solutions, the hetero-aggregation reaction of HMTA with water is the dominant mechanism, while at higher concentrations a self-aggregation mechanism occurs. Ultrasonic absorption and velocity measurements were carried out for hexamethylenetetramine aqueous solutions. The acoustic spectra reveal the presence of only one single Debye-type relaxation process that is assigned to the aggregation mechanism of HMTA. The sound absorption data follow two different dependencies on HMTA mole fraction. The crossover 0.018 mole fraction signifies two separate regions with distinct structural characteristics. The relaxation mechanism observed in dilute solutions is attributed to hetero-association of HMTA with water molecules, while at higher concentrations the observed relaxation process is assigned to the self-association reaction of HMTA molecules. This structural transformation is also reflected in several physicochemical properties of the system, including the kinematic viscosity, the mass density, the sound speed, and the adiabatic compressibility of the HMTA aqueous solutions. The combination of vibrational and acoustic spectroscopies with molecular orbital calculations allowed us to disentangle the underlying processes and to elucidate the observed relaxation mechanism in the HMTA aqueous solutions.

Preprint ARTICLE | doi:10.20944/preprints202311.0001.v1

Epidemiology of Antimicrobial Resistance Genes in Staphyloccocus aureus Isolates from a Public Database in a One Health Perspective – Sample Origin and Isolates Geographical Distribution

Francesca Zaghen, Valerio Massimo Sora, Gabriele Meroni, Giulia Laterza, Piera Anna Martino, Alessio Soggiu, Luigi Bonizzi, Alfonso Zecconi

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: S. aureus; One Health; antimicrobial resistance; molecular epidemiology; geographical distribution.

Online: 1 November 2023 (09:41:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1852.v1

Challenges to Cannabis sativa Production from Pathogens and Microbes – the Role of Molecular Diagnostics and Bioinformatics

ZAMIR PUNJA, Dieter Kahl, Ron Reade, Yu Xiang, Jack Munz, Punya Nachappa

Subject: Biology And Life Sciences, Plant Sciences Keywords: bioinformatics; cannabis; hemp; hop latent viroid; molecular diagnostics; plant pathogens

Online: 30 October 2023 (09:54:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0464.v1

Prevalence and Genetic Characterization of Morphologically Indistinguishable Sarcocysts of Sarcocystis cruzi in Cattle and Sarcocystis poephagicanis in Yaks

Kui Tang, Danqu Lamu, Tao Qin, Zhe Liao, Mingzhu Zhang, Zhipeng Wu, Shuangsheng Deng, Jianping Tao, Junjie Hu

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Sracocystis cruzi; Sarcocystis poephagicanis; cattle; yak; morphological and molecular characterization

Online: 9 October 2023 (10:36:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1302.v1

Molecular Identification of Xanthomonas oryzae pv. oryzae and Bacterial Leaf Blight Resistance Genes Xa5, and Xa21 in Cultivated Rice Accessions Benin

Chimène Nadège Mahoussi Nanoukon, Koffi David Hambada Montcho, Antoine Abel Missihoun, Kéllya Laurinzo Déguénon, Bignon Meyrix Paméla Franzel Loumédjinon, Emilienne ZINSOU, Emilienne Zinsou, Réel Gael Fael Hougbélagnon, Amed Havivi, Lamine Baba-Moussa, Lambert Gustave Djédatin

Subject: Biology And Life Sciences, Plant Sciences Keywords: Bacterial blight; Xanthomonas oryzae pv. oryzae; molecular characterization; resistance genes

Online: 19 September 2023 (11:00:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1885.v1

A Comprehensive Comparative Analysis of Deep Learning based Feature Representations for Molecular Taste Prediction

Yu Song, Sihao Chang, Jing Tian, Weihua Pan, Lu Feng, Hongchao Ji

Subject: Chemistry And Materials Science, Food Chemistry Keywords: Cheminformatics; Taste prediction; Machine learning; Deep learning; Molecular feature representation

Online: 29 August 2023 (03:06:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1696.v1

Molecular Resonance Imaging of the CAIX expression in Mouse Mammary Adenocarcinoma Cells

Claudia Quattrociocchi, Alberto Mangia, Silvio Aime, Valeria Menchise, Daniela Delli Castelli

Subject: Biology And Life Sciences, Life Sciences Keywords: MRI; Molecular Imaging; CAIX; Breast cancer; Gd-contrast agent; liposomes

Online: 24 August 2023 (09:39:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0879.v1

Enhanced risk stratification in early-stage endometrial cancer: Integrating Molucular-L1CAM Classification and Simplified L1CAM/p53 Categorization

Seungyeon Joe, Miseon Lee, Jun Kang, Joori Kim, Sook-Hee Hong, Sung Jong Lee, Keun Ho Lee, Ahwon Lee

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: early-stage endometrial cancer; molecular classification; L1CAM; risk stratification; prognosis

Online: 11 August 2023 (08:38:07 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.0605.v1

Insight and Recommendations for Fragile X Premutation Associated Conditions from the 5th International Conference on FMR1 Premutation

Flora Tassone, Dragana Protic, Emily Allen, Alison D. Archibald, Anna Baud, W Ted Brown, Dejan B. Budimirovic, Jonathan Cohen, Brett Dufour, Rachel Eiges, Nicola Elvassore, Lidia V. Gabis, Samantha J Grudzien, Deborah Hall, David Hessl, Abigail Hogan, Jessica Ezzell Hunter, Peng Jin, Poonnada Jiraanont, Jessica Klusek, R. Frank Kooy, Claudine M Kraan, Cecilia Laterza, Andrea Lee, Karen Lipworth, Molly Losh, Danuta Z Loesch, Reymundo Lozano, Marsha Mailick, Apostolos Manolopoulos, Verónica Martínez-Cerdeño, Yingratana Amabel McLennan, Robert M. Miller, Alice Montanaro, Matthew W. Mosconi, Sarah Potter, Melissa Raspa, Susan M. Rivera, Katharine Shelly, Peter K. Todd, Katarzyna Tutak, Jun Yi Wang, Anne C Wheeler, Tri Indah Winarni, Marwa Zafarullah, Randi Hagerman

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: FMR1 premutation; FXPAC; FXTAS; FXAND; FXPOI; FMR1 molecular and clinical

Online: 10 July 2023 (10:27:07 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.0229.v1

The Unmet Diagnostic and Treatment Needs in Large Cell Neuroendocrine Carcinoma of the Lung

Catalin Buium, Serban Negru, Diana Ionescu, Mircea Dediu

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: large cell; neuroendocrine; lung cancer; pathology; molecular subtypes; diagnosis; treatment

Online: 4 July 2023 (12:28:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0010.v1

Use of Biomarkers to Improve 28-Day Mortality Stratification in Patients with Sepsis and SOFA≤6

Jaume Baldirà, Juan Carlos Ruiz-Rodríguez, Adolfo Ruiz-Sanmartin, Luis Chiscano, Alejandro Cortés, Diego Angeles-Sistac, Roser Ferrer-Costa, Imma Comas, Yolanda Villena, M.Nieves Larrosa, Juan José González-López, Ricard Ferrer

Subject: Medicine And Pharmacology, Emergency Medicine Keywords: Sepsis biomarkers; mortality; MR-proADM; SOFA score; Lactate; molecular diagnosis

Online: 3 July 2023 (08:10:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.2214.v1

Mechanistic Elucidation of Activation/Deactivation Signal Transduction within Neurotensin Receptor 1 Triggered by ‘Driver Chemical Groups’ of Modulators: A Comparative Molecular Dynamics Simulation

Xun Lu, Xinchao Shi, Jigang Fan, Mingyu Li, Yuxiang Zhang, Shaoyong Lu, Guanhuan Xu, Ziqiang Chen

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Neurotensin receptor 1; molecular dynamic simulation; signal transduction; selective interaction

Online: 30 June 2023 (10:36:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0967.v1

A Computational (DFT) Study On The Anti-Malarial Drug: Lumefantrine

Ahmet Kunduracioglu

Subject: Chemistry And Materials Science, Theoretical Chemistry Keywords: Lumefantrine; Anti-malarial activity; Spectral analysis; HOMO-LUMO; Molecular structure

Online: 14 June 2023 (03:28:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1768.v1

Ammonia and Humidity Sensing by Phthalocyanine-Corrole complex Heterojunction Devices

Lorena Di Zazzo, Sujithkumar Ganesh Moorthy, Rita Meunier-Prest, Corrado Di Natale, Roberto Paolesse, Marcel Bouvet

Subject: Chemistry And Materials Science, Nanotechnology Keywords: corrole; phthalocyanine; gas sensor; organic heterojunction; conductometric transducer; molecular material

Online: 25 May 2023 (08:31:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1546.v1

Novel Oleanolic Acid-Phtalimidines Tethered 1,2, 3 Triazole Hy-Brids As Promising Antibacterial Agents: Design, Synthesis, In Vitro Experiments and In Silico Docking Studies

Ghofrane Lahmadi, Mabrouk Horchani, Amal Dbeibia, Abdelkarim Mahdhi, Anis Romdhane, Ata Martin Lawson, Adam Daïch, Abdel Halim Harrath, Hichem Ben Jannet, And Mohamed Othman

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: Oleanolic acid; phtalimidines; triazole; click chemistry; antibacterial activity; molecular docking

Online: 23 May 2023 (03:33:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1530.v1

Drought-Responsive Genes in Tomato: Meta-Analysis of Gene Expression using Machine Learning

Rabiul Haq Chowdhury, Fatiha Sultana Eti, Md. Atiqur Rahman Bhuiyan, Shipan Das Gupta, Mehede Hassan Rubel

Subject: Biology And Life Sciences, Plant Sciences Keywords: Abiotic stresses; Molecular breeding; Machine learning; Responsive genes; Adapted crops

Online: 22 May 2023 (15:29:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1304.v1

Molecular Networks of Platinum Drugs and Arsenic Trioxide and Its Interaction With microRNAs in Cancer

Shihori Tanabe, Eger Boonstra, Taehun Hong, Sabina Quader, Ryuichi Ono, Horacio Cabral, Kazuhiko Aoyagi, Hiroshi Yokozaki, Hiroki Sasaki

Subject: Biology And Life Sciences, Life Sciences Keywords: drug resistance; cisplatin; arsenic; tumor microenvironment; microRNA; molecular pathway network

Online: 18 May 2023 (08:41:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0281.v1

Computational Characterization of the Binding Properties of the HIV1-Neutralizing Antibody PG16 and Design of PG16-Derived CDRH3 Peptides

Manuel Deubler, Lucas Weißenborn, Simon Leukel, Anselm H.C. Horn, Jutta Eichler, Heinrich Sticht

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Antibody; PG16; HIV-1; peptides; antibody mimetic peptides; molecular dynamics

Online: 5 May 2023 (03:08:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1066.v1

Unveiling the Intimate Mechanism of the Crocin Antioxidant Properties by Radiolytic Analysis and Molecular Simulations

Sarah Al Gharib, Pierre Archirel, Daniel Adjei, Jacqueline Belloni, Mehran Mostafavi

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: crocin; antioxidant properties; pulse radiolysis; gamma radiolysis; molecular simulation; mechanism.

Online: 27 April 2023 (09:55:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0694.v1

Medical Applications of Molecular Biotechnologies in the Context of the Hashimoto’s Thyroiditis

Maria Trovato, Andrea Valenti

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Hashimoto’s thyroiditis; molecular biotechnologies; clinical trials studies; hygiene hypothesis; parvoviruses

Online: 21 April 2023 (08:48:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0209.v1

Uncovering Taste-Active Metabolites in Chili Sauce Fermentation Through Metabolomics and Web-based Computing Tools Analysis

Jiaqi Wang, Sen Mei, Chi Jin, Muhammad Aamer Mehmood, Qing Zhang, Tao Hu, Weili Li, Tao Wu

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: chili sauce; Lactiplantibacillus plantarum; feature-based molecular network; metabolomics; taste

Online: 13 March 2023 (03:09:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0059.v1

Exploring the Unbinding Mechanism of Drugs from SERT via Molecular Dynamics Simulation and Its Implication in Antidepressants

Xin-Guan Tan, Xue-Feng Liu, Xin Li, Ming-Hui Pang, Yu-Qing Wang, Yun-Jie Zhao

Subject: Biology And Life Sciences, Biophysics Keywords: hSERT; comprehensive molecular dynamics (MD) simulation; drug design; MM/GBSA

Online: 3 February 2023 (06:16:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0168.v1

Aquaporin-2 Interaction with Cortisol Modulates its Water Permeability. Perspectives for Corticosteroids Non-genomic Effects

Robin Mom, Stéphane Réty, Daniel Auguin

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: AQP2; cortisol; corticosteroid; non-genomic effects; molecular dynamics; water permeability

Online: 9 December 2022 (02:31:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202208.0217.v1

Ferromagnetic Coupling and Single-Ion Magnet Phenomenon in Mononuclear Ruthenium(Iii) Complexes Based on Guanine Nucleobase

Marta Orts-Arroyo, Nicolás Moliner, Francesc Lloret, José Martínez-Lillo

Subject: Chemistry And Materials Science, Inorganic And Nuclear Chemistry Keywords: Ruthenium; crystal structures; ferromagnetic coupling; molecular magnetism; single-ion magnet.

Online: 11 August 2022 (11:41:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0442.v1

Performance Comparison of a Duplex Implementation of the CDC EUA 2019-nCoV Assay with the Seegene Allplex-SARS-CoV-2 Assay for the Detection of SARS-CoV-2 in Nasopharyngeal Swab Samples

Karen Marcela Jiménez, Dora Janeth Fonseca-Mendoza, Adrien Morel, Oscar Ortega-Recalde, Nora Contreras, Camilo Andres Velandia-Piedrahita, Adriana Steevens, Luisa Caldas, Juan Pablo Ribón, Martha Sanchez, Carlos Martín Restrepo, Rodrigo Cabrera

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: COVID-19; molecular diagnostic; SARS-CoV-2; Real-time PCR

Online: 29 July 2022 (03:10:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0078.v2

Mitochondrial Damage-Associated Molecular Patterns Content in Extracellular Vesicles Promotes Early Inflammation in Neurodegenerative Disorders

Claudia Deus, Henrique Tavares, Margarida Beatriz, Sandra Mota, Carla Lopes

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Extracellular vesicles; neurodegenerative disorders; mitochondrial damage-associated molecular patterns; inflammation

Online: 6 July 2022 (09:16:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0099.v1

SARS-CoV-2 Shielding Effect of Chitosan Derivatives: An in-silico Prospective

Poonam Das, Sabuj Sahoo, Sanatan Majhi, George rout Kerry, Atala Bihari Jena

Subject: Biology And Life Sciences, Virology Keywords: Chitosan; mHTCC; SARS-CoV-2; S protein; ACE2; Molecular interaction

Online: 7 June 2022 (09:05:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0143.v1

Immunoinformatic Guided Rational Design of a Next Generation Multi Epitope Based Peptide Vaccine against Marburg Virus Disease Combined with Molecular Docking Studies

Mujahed Mustafa, Shaza Shantier

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Marburg virus disease (MVD); Vaccine design; Immunoinformatic; Molecular Docking Study.

Online: 10 May 2022 (14:16:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0005.v1

Metabolomic Comparison Using Streptomyces spp as a Factory of Secondary Metabolites

Rene Flores Clavo, Alana Kelyene Pereira, Nataly Ruiz Quiñones, Jonas Henrique Costa, Taícia Pacheco Fill, Fabiana Fantinatti Garboggini

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: genome mining; marine environments; molecular networking; bacterial extremophiles; secondary metabolites

Online: 1 April 2022 (10:21:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0222.v1

Identification of CT Attenuation Values that Could be Predictive of Necrosis (N-CTav) in Hepatocellular Carcinoma Tumors after Lenvatinib Treatment and the Association between the N-CTav Occupancy Rate in the Tumor and Maintenance of Complete Response with Lenvatinib Treatment

Makoto Chuma, Hideki Yokoo, Atsushi Hiraoka, Kazuhiko Ueda, Takahiro Yokoyama, Kunihiko Tsuji, Noritomo Shimada, Haruki Uojima, Satoshi Kobayashi, Nobuhiro Hattori, Tomomi Okubo, Masanori Atsukawa, Toru Ishikawa, Koichi Takaguchi, Akemi Tsutsui, Hidenori Toyoda, Toshifumi Tada, Yoshinori Saito, Shunji Hirose, Takaaki Tanaka, Kazuhisa Takeda, Masako Otani, Zenjiro Sekikawa, Tsunamasa Watanabe, Hisashi Hidaka, Manabu Morimoto, Kazushi Numata, Tatehiro Kagawa, Michiie Sakamoto, Takashi Kumada, Shin Maeda

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: hepatocellular carcinoma; lenvatinib; molecular targeted agents; complete response; CT value

Online: 18 February 2022 (04:05:18 CET)

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Purpose: To assess the utility of measurement of the computed tomography (CT) attenuation value (CTav) in predicting tumor necrosis in hepatocellular carcinoma (HCC) patients who achieve a complete response (CR), defined using modified Response Evaluation Criteria in Solid Tumors (mRECIST), after lenvatinib treatment. Method: We compared CTav in arterial phase CT images with postoperative histopathology in four patients who underwent HCC resection after lenvatinib treatment, to determine CTav thresholds indicative of histological necrosis (N-CTav). Next, we confirmed the accuracy of the determined N-CTav in 15 cases with histopathologically proven necrosis in surgical specimens. Furthermore, the percentage of the tumor with N-CTav, i.e. the N-CTav occupancy rate, assessed using Image J software in 30 tumors in 12 patients with CR out of 571 HCC patients treated with lenvatinib, and its correlation with local recurrence following CR were examined. Results: Receiver operating characteristic (ROC) curve analysis revealed an optimal cut-off value of CTav of 30.2 HU, with 90.0% specificity and 65.0% sensitivity in discriminating between pathologically identified necrosis and degeneration, with a CTav of less than 30.2 HU indicating necrosis after lenvatinib treatment (N30-CTav). Furthermore, the optimal cut-off value of 30.6% for the N30-CTav occupancy rate by ROC analysis was a significant indicator of local recurrence following CR with 76.9% specificity and sensitivity (area under the ROC curve; 0.939), with the CR group with high N30-CTav occupancy (>30.6%) after lenvatinib treatment showing significantly lower local recurrence (8.3% at 1 year) compared with the low (<30.6%) N30-CTav group (P<0.001, 61.5% at 1 year). Conclusion: The cut-off value of 30.2 HU for CTav (N30-CTav) might be appropriate for identifying post-lenvatinib necrosis in HCC, and an N30-CTav occupancy rate of >30.6% might be a　predictor of maintenance of CR. Use of these indicators have the potential to impact systemic chemotherapy for HCC.

Preprint REVIEW | doi:10.20944/preprints202202.0004.v1

Mapping Spatiotemporal Heterogeneity in Tumour Progression by Integrating High-Throughput Imaging and Omics Analysis

Pooja Annasaheb Patkulkar, Ayalur Raghu Subbalakshmi, Mohit Kumar Jolly, Sanhita Sinharay

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Spatial transcriptomics; Molecular imaging; single-cell RNA-seq; intratumoral heterogeneity

Online: 1 February 2022 (11:08:51 CET)

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Preprint REVIEW | doi:10.20944/preprints202201.0084.v1

Yeast Hybrids in Brewing

Matthew J. Winans

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: hybrid; lager; yeast; introgression; interspecific; domestication; phylogeny; brewing; molecular; genomics

Online: 6 January 2022 (11:55:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0254.v1

Changes in the Local Conformational States Caused by Simple Na+ and K+ Ions in Polyelectrolyte Simulations: Comparison of Seven Force Fields With and Without NBFIX and ECC Corrections

Natalia Lukasheva, Dmitry Tolmachev, Hector Martinez-Seara, Mikko Karttunen

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: Peptides and proteins; Counterions; Ions; Carboxyls; Molecular dynamics; Force fields

Online: 15 December 2021 (11:14:28 CET)

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