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Preprint ARTICLE | doi:10.20944/preprints202406.0582.v1

It Is Not Always Bad, Positive Experiences of Guardians Utilizing Vhembe Primary Health Care Facilities for Under-Five Child Health Services: An Interpretative Phenomenology Study

Livhuwani Tshivhase, Idah Moyo, Sophy Mogatlogedi Moloko

Subject: Public Health And Healthcare, Primary Health Care Keywords: Child health services; guardians; positive experiences; primary healthcare; under-five child

Online: 11 June 2024 (15:03:33 CEST)

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Introduction: Guardians play a pivotal role in the management of childhood illness. Their responsibilities include home managing childhood illnesses and supporting continuity of care following healthcare facility treatment. Evidence has shown that guardians' negative experience in health care facilities when accessing under-five childcare services impacts their utilization of such facilities. Exploration of guardians' experiences is important in providing the evidence base necessary for quality childcare and reducing under-five morbidity and mortality. The study aimed to explore the experiences of guardians of children under five regarding the care received in Vhembe healthcare facilities. Methods: A qualitative approach using an interpretative phenomenology analysis (IPA) was used for this study. The study was conducted in eight primary healthcare facilities in the Vhembe district, with the highest headcount for children under five. Sixteen guardians were purposefully sampled for the study. Data analysis was done following the IPA steps of data analysis. Trustworthiness criteria were followed: credibility, confirmability, dependability, authenticity, and transferability. Ethical approval was obtained from the university and the province, followed by permission from the district and the operational managers before data collection. Results: The three emerging themes are associated with participants' positive experiences as they interfaced within the healthcare system: quality care, healthcare environment, support, and empowerment. The ten sub-themes were: timely service provision, availability of medicines, perceived nursing competence and professionalism, person-centred care, welcoming environment, effective communication, positive attitude of healthcare providers, guardians’ satisfaction with care received, guardians' involvement in childcare and community support. Conclusion: It is indeed not always bad. The participants in this study had positive care experiences, which is crucial in the optimal utilization of health care services, resulting in improved health outcomes.

Preprint ARTICLE | doi:10.20944/preprints202405.1654.v1

The Importance of Green Investments in Developed Economies—MCDM Models for Achieving Adequate Green Investments

Vladimir Ristanović, Dinko Primorac, Barbara Dorić

Subject: Business, Economics And Management, Business And Management Keywords: Green Transition; OECD Green Growth Indictors; AHP method; BWM method

Online: 24 May 2024 (13:18:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0582.v1

Advances in the Synthesis of Graphene: A Comprehensive Review

gopal gupta, Ajeet gupta

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: graphene; 2d materials

Online: 9 May 2024 (10:35:45 CEST)

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Preprint DATA DESCRIPTOR | doi:10.20944/preprints202403.1848.v1

Improving Code Smell Detection Using Deep Stacked Autoencoder

Kadem K. Rehef, Ahmed S. Abbas

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: machine learning; deep learning; stack auto encoder; code smell detection; auto encoder.

Online: 29 March 2024 (10:41:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0134.v1

Assessing the Reliability of Machine Learning Models Applied to the Mental Health Domain Using Explainable AI

Vishnu S Pendyala, HyungKyun Kim

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Explainable AI; Machine Learning; Mental Health; Model Evaluation

Online: 4 March 2024 (11:26:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints201703.0015.v1

Evolutionary Optimization of Colebrook’s Turbulent Flow Friction Approximations

Dejan Brkić, Žarko Ćojbašić

Subject: Physical Sciences, Fluids And Plasmas Physics Keywords: colebrook equation; colebrook-white; moody diagram; turbulent flow; hydraulic resistance; darcy friction; pipes; genetic algorithms; optimization techniques; error analysis

Online: 2 March 2017 (07:57:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints201610.0136.v1

Food Security Condition of Smallholding Farmers in Kilte Awelalo, Ethiopia

Tinsaye Tamerat, Dharitry Borah

Subject: Business, Economics And Management, Economics Keywords: food security, rural livelihoods

Online: 31 October 2016 (07:59:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0096.v1

Evaluating the Impact of Corporate Governance on Firm Performance Using Board Index

Basil Okoth, Metin Coşkun

Subject: Business, Economics And Management, Finance Keywords: corporate governance; EVA; board of directors; board index; EVA

Online: 9 August 2016 (11:51:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0325.v1

Can NIR Replace a Panel of Tasters in Sensory Analysis of Dry-Cured Bísaro Loin?

Lia Vasconcelos, Luís G. Dias, Ana Leite, Iasmin Ferreira, Etelvina Pereira, Evandro Bona, Javier Mateo, Sandra Rodrigues, And Alfredo Teixeira

Subject: Biology And Life Sciences, Food Science And Technology Keywords: dry-cured Bísaro loin; NIR analysis; sensory attributes; non-linear SVR models.

Online: 6 November 2023 (10:27:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.2259.v1

Probabilistic Cellular Automata Monte Carlo for the Maximum Clique Problem

Alessio Troiani

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: Maximum Clique Problem; Probabilistic Cellular Automata; Monte Carlo Markov Chain; QUBO; Parallel Computing

Online: 30 August 2024 (14:56:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0023.v20

Bell's Theorem Begs the Question

Joy Christian

Subject: Physical Sciences, Quantum Science And Technology Keywords: Bell’ s theorem; local realism; Bell-CHSH inequalities; quantum correlations; Bell-test experimentsexperiments

Online: 29 August 2024 (09:53:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1978.v1

Evaluating the Influence of ESG Ratings on the Corporate Operational Performance: Evidence from Commercial Banks in China

Honglin Wang

Subject: Business, Economics And Management, Finance Keywords: ESG rating; Commercial Banks; Operating Performance; Empirical Analysis

Online: 28 August 2024 (12:57:41 CEST)

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Preprint ESSAY | doi:10.20944/preprints202408.2004.v1

A More-than-Human Ecology; Evolving Generative Artificial Intelligence in Higher Education

James Fern

Subject: Social Sciences, Education Keywords: generative artificial intelligence; higher education; assessment and feedback

Online: 28 August 2024 (09:04:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1184.v1

Evaluating Kolmogorov–Arnold Networks for Scientific Discovery: A Simple Yet Effective Approach

Josh Sun

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Machine Learning; Neural Networks; Interpretable AI; AI4Science

Online: 19 August 2024 (18:13:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1186.v1

Tubular Release of N-acetylglucosaminidase Into Glomerular Filtrate is Minimally Related to Cadmium-Induced Nephron Destruction

Soisungwan Satarug

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: cadmium; glomerular filtration rate; mediation analysis; N-acetyl-β-D-glucosaminidase; nephrotoxicity threshold

Online: 16 August 2024 (09:51:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0972.v2

Seismic Nowcasting: A Holistic Artificial Neural Network Predictive Model

Anastasios Bikos

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: earthquake nowcasting; machine learning; game-theory; clustering; seismic risk; statistical methods; long short-term memory neural network

Online: 16 August 2024 (09:30:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1127.v1

A Recurrent Proof of the Fundamental Theorem of Algebra

Vincenzo Manca

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Fundamental Theorem of Algebra; Recurrent Equation; Polynomial Coefficient Function; Complex Hyperspace

Online: 15 August 2024 (15:19:41 CEST)

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Preprint ESSAY | doi:10.20944/preprints202408.0173.v1

Supervision of Biomedical Master’s Students in Norway

Valentyn Oksenych

Subject: Social Sciences, Education Keywords: supervision; MSc; research project; biomedicine; biology; Norway

Online: 5 August 2024 (05:12:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.2100.v1

Scoping Review of COVID-19 Vaccine Hesitancy in Japanese Healthcare Providers

Carol Nash

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: COVID-19; Japan; vaccine hesitancy; healthcare providers; databases

Online: 26 July 2024 (06:20:33 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202406.1849.v1

An Initial Approach of Multiple Linear Regression in CO₂-water Relative Permeability Prediction for Carbon Storage Projects

Ying Yu

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: CCUS; Relative permeability; Supervised learning

Online: 26 June 2024 (11:35:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.2046.v2

Linking the Expansion of the Universe to the Dimension of Time

Gary Jarvis

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: universe expansion; gravity; wave-particle-duality; electromagnetism; quantum entanglement

Online: 17 June 2024 (08:02:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0156.v2

Open-source-based Approach to Delineate the Shoreline from Space: A Case Study in Failaka Island, the State of Kuwait

Jasem Albanai

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: Remote sensing (RS); Geographic Information system (GIS); geography; coastal geomorphology; Arabian Gulf

Online: 6 June 2024 (11:50:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0359.v2

A Turing Test for Self-Awareness

Cameron Witkowski

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Self-Awareness; Self-Consciousness; Turing; LLM; Meaning; Understanding

Online: 31 May 2024 (10:52:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1701.v1

Monetary Transmission & Small Firm Credit Rationing Stable-Coin Configuration Opportunities to Raise Small Firm Credit Flows

Richard Simmons

Subject: Business, Economics And Management, Economics Keywords: Credit Rationing; Monetary Transmission; Stable-Coin; Synthetic Central Bank Digital Currency; Small Firms; Real Economy; Growth; Monetary Policy; Counter Cyclical

Online: 27 May 2024 (11:39:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1471.v1

A Turing Machine for the Life Sciences

Spencer Spratt

Subject: Biology And Life Sciences, Life Sciences Keywords: Turing machine; Drosophila; Mutual exclusivity; Specificity; In vivo database searching; Machine learning

Online: 23 May 2024 (02:56:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0756.v1

Formal Language for Objects’ Transactions (ObTFL)

Mo Adda

Subject: Computer Science And Mathematics, Data Structures, Algorithms And Complexity Keywords: formal language; activities; interactions; actors; agents; transactions; compartments; junctions; containers

Online: 13 May 2024 (07:56:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0271.v1

Green Hydrogen Integration for Decarbonization: Solving Challenges in “Hard-to-Abate” Sectors

Alessandro Franco

Subject: Engineering, Energy And Fuel Technology Keywords: Energy transition; Decarbonisation; Hard-to-abate sectors; Hydrogen applications; Sustainable production; Steel industry

Online: 6 May 2024 (08:40:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1652.v1

Powering the Future: An Integrated Framework for Clean Renewable Energy Transition

Hanan Wehbi

Subject: Environmental And Earth Sciences, Sustainable Science And Technology Keywords: ; energy transition; Clean renewable energy communities; metrics; sustainable land use; energy planning; sustainability; resilience ;

Online: 25 April 2024 (08:36:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1254.v1

Symphony in the Brain

Pavlo Mikheenko

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: brain; microtubules; superconductivity; Josephson radiation

Online: 19 April 2024 (07:56:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0230.v1

All PFOs Should Be Closed

Bernhard Meier

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Angina pectoris; atrial septal defect; collateral benefit; device closure; left atrial appendage; mechanical vaccination; migraine; myocardial infarction; patent foramen ovale; paradoxical embolism; peripheral embolism; primary prevention; stroke; transient ischemic attack

Online: 3 April 2024 (08:11:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0556.v1

The Use of AI in Software Engineering: Synthetic Knowledge Synthesis of Recent Research Literature

Peter Kokol

Subject: Computer Science And Mathematics, Software Keywords: Software engineering; Artificial Intelligence; Machine learning; Synthetic Knowledge Synthesis

Online: 11 March 2024 (08:58:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202001.0350.v3

Insights of Gravitational Phenomena: A Study Applying Thermodynamic Properties of Gases

Chithra Piyadasa

Subject: Physical Sciences, Other Keywords: gravitational attraction; gravitational repulsion; thermal energy; inverse cube law; thermodynamic properties of gas

Online: 8 March 2024 (15:31:32 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1651.v1

A Novel Low-Tech Water Treatment System to Provide Safe Water for the Rural Poor

Edward McBean

Subject: Engineering, Civil Engineering Keywords: Low-tech; ceramic filter; safe water; full schools; long term performance; easy to use; robust performance; girl’ s education

Online: 28 February 2024 (16:01:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1341.v1

What do Stimulated Beta Cells have in Common with Cancer Cells?

Marko Marhl

Subject: Biology And Life Sciences, Biophysics Keywords: Diabetes; Cancer; Reductive metabolism; NADPH; GSH; Nrf2 pathway; UCP2; Succinate; HIF

Online: 23 February 2024 (09:16:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202004.0468.v2

Inflation of Universe by nonlinear electrodynamics

Sergey Kruglov

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Universe inflation; Einstein's gravity; nonlinear electrodynamics; e-folding number; classical stability; causality

Online: 19 February 2024 (14:51:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.1510.v1

Research on Status Assessment and Operation & Maintenance of Electric Vehicle DC Charging Stations based on XGboost

HUALIANG FANG, Jiaqi Liao, Shuo Huang, Maojie Zhang

Subject: Engineering, Electrical And Electronic Engineering Keywords: DC charging station; XGBoost; traffic simulation; operation and maintenance

Online: 21 August 2024 (08:39:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202007.0224.v1

An Updated Overview of the Neurophysiological and Psychosocial Dimensions of Fibromyalgia – A Call for an Integrative Model

Ana Margarida Pinto, Rinie Geenen, Filipe Palavra, Mark A. Lumley, Jacob N. Ablin, Kirstine Amris, Jaime Branco, Dan Buskila, Miguel Castelo-Branco, Leslie J. Crofford, Mary-Ann Fitzcharles, Mariana Luís, Tiago Reis Marques, Jamie L. Rhudy, Lucina Q. Uddin, Paula Castilho, Johannes W. G. Jacobs, José A. P. da Silva

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: fibromyalgia; comprehensive review; neurophysiological abnormalities; psychosocial processes; integration

Online: 11 July 2020 (03:45:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1430.v1

Design, Synthesis and Photophysical Properties of 5-Aminobiphenyl Substituted [1,2,4]triazolo[4,3-c]- and [1,2,4]triazolo[1,5-c]quinazolines

Tatyana N. Moshkina, Alexandra E. Kopotilova, Marya A. Ivan’kina, Ekaterina S. Starnovskaya, Denis A. Gazizov, Emiliya V. Nosova, Dmitry S. Kopchuk, Oleg S. El´tsov, Pavel A. Slepukhin, Valery N. Charushin

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: [1,2,4]Triazolo[4,3-c]quinazoline; [1,2,4]triazolo[1,5-c]quinazoline; cross-coupling; fluorescence; solvatochromism

Online: 23 April 2024 (08:00:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0469.v1

Pandemic Coronavirus Disease (COVID-19): Challenges and A Global Perspective

Yashpal Singh Malik, Naveen Kumar, Shubhankar Sircar, Rahul Kaushik, Sudipta Bhatt, Kuldeep Dhama, Parakriti Gupta, Kapil Goyal, Mini P. Singh, Ujjala Ghoshal, Mohamed Ezzat Mahmoud El Zowalaty, O.R. Vinodh Kumar, Mohd. Iqbal Yatoo, Ruchi Tiwari, Mamta Pathak, Shailesh Kumar Patel, Ranjit Sah, Alfonso J. Rodriguez-Morales, Balasubramanian Ganesh, Prashant Kumar, Raj Kumar Singh

Subject: Biology And Life Sciences, Virology Keywords: severe acute respiratory syndrome coronavirus-2; COVID-2019; epidemiology; pathobiology; clinical profile; phyloanalysis; artificial intelligence; diagnosis; vaccines; therapeutics

Online: 26 April 2020 (08:15:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0187.v1

Minimally Invasive Surgery for Adult Spinal Deformity Using Lateral Lumbar Interbody Fusion

Seung Won Park, Young-Seok Lee, Myeong Jin Ko, Seong Hyun Wui

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: adult spinal deformity; minimally invasive surgery; lateral lumbar interbody fusion; percutaneous pedicle screw fixation; marked sagittal deformity

Online: 2 August 2024 (13:07:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1633.v1

Title Application of Different Echocardiographic Parameters in Sepsis-induced Cardiomyopathy

Fang Xiong, Hongyan Pan, Pengfei Pan

Subject: Medicine And Pharmacology, Emergency Medicine Keywords: sepsis-induced cardiomyopathy; echocardiography; application; research progress

Online: 22 July 2024 (09:43:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0993.v1

Free Vibration Analysis of Curvilinearly Tapered Axially Functionally Graded Material Beams

Vyacheslav N. Burlayenko, Reijo Kouhia, Svetlana D. Dimitrova

Subject: Engineering, Mechanical Engineering Keywords: free vibrations; axially functionally graded material; curvilinear tapered beam; differential transform method; ABAQUS

Online: 12 July 2024 (11:09:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0946.v1

IDENTIFICATION OF DOMINANT PARAMETERS IN THE PREDICTION OF STATUS OF PEDIATRIC CONGENITAL HEART DISEASES ICU PATIENTS

Sharmin Nahar Sharwardy, Hasan Sarwar, Mohammad Nurul Akhtar Hasan, Mohammad Zahidur Rahman

Subject: Computer Science And Mathematics, Analysis Keywords: Congenital heart diseases; Pediatric; Linear model; ARIMA model; Cause-effect; ICU

Online: 11 July 2024 (10:46:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.0822.v1

Macular Pigment Optical Density a Measurable Modifiable Clinical Biomarker

Abdul Masri, Mohammed Armanazi, Keiko Inouye, Dennis Gierhart, Pinakin Gunvant Davey, Balamurali Vasudevan

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: MPOD; lutein; zeaxanthin; biomarker; glaucoma; diabetic retinopathy

Online: 10 July 2024 (05:08:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1745.v1

A study on the Effectiveness of Competency Mapping in Software Companies

Vinay Kumar Pothula, Suman Kumar Naredla, Geetha Manoharan, Debolina Gupta

Subject: Business, Economics And Management, Human Resources And Organizations Keywords: Competency Mapping; Performance; Organizational effectiveness; People; Software Companies; Skills of the Employee; strengths and weakness; Job Performance

Online: 25 June 2024 (08:09:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0548.v1

An Analytical Approach to Power Optimization of Concentrating Solar Power Plants with Thermal Storage

Andrii Cheilytko, Spiros Orestis Alexopoulos, Andriy Pozhuyev, Oliver Kaufhold

Subject: Engineering, Energy And Fuel Technology Keywords: concentrated solar power; thermal storage; hybrid solar power plants; design factor; solar multiple factor; optimization model; analytical approach

Online: 10 May 2024 (03:32:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0426.v1

Exploring Novel Biomarkers for an Acute Coronary Syndrome Diagnosis Utilizing Plasma Metabolomics

Masayuki Shibata, Masahiro Sugimoto, Norikazu Watanabe, Atsuo Namiki

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: acute coronary syndrome; biomarker; metabolomics; multiple logistic regression model

Online: 8 May 2024 (11:25:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0452.v1

Factors that Influence Resilience among Undergraduate First-Year Nursing Students: A Cross-Sectional Descriptive Study

Gopolang Gause, Leepile Alfred Sehularo, Molekodi Jacob Matsipane

Subject: Public Health And Healthcare, Nursing Keywords: first year nursing students; nursing; nursing students; resilience; undergraduate; undergraduate nursing students

Online: 8 April 2024 (13:57:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202402.1068.v1

Impact of AGN feedback on the dynamics of gas; A Review across Diverse Environments

Mojtaba Raouf, Mohammad Hossein Purabbas, Fatemeh Fazel Hesar

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: galaxy groups, blackhole activity, AGN feedback, kinematic misalignment, mergers, group dynamics, radio luminosity, stellar populations, galaxy formation

Online: 19 February 2024 (14:54:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints201607.0083.v1

Low Carbon Urban Transitioning in Shenzhen: A Multi-Level Environmental Governance Perspective

Zhanglan Wu, Jie Tang, Dong Wang

Subject: Social Sciences, Political Science Keywords: urban sustainability; environmental governance; energy policy

Online: 27 July 2016 (05:56:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.1309.v1

Post-acute Sequelae of SARS-CoV2: A Narrative Review and Meta-Analysis of Individual Symptom Frequencies

Rachel Atchley-Challenner, Zachary H. Strasser, Deepti Pant, Aparna Krishnamoorthy, Lori B. Chibnik, Elizabeth W. Karlson

Subject: Public Health And Healthcare, Other Keywords: narrative review; long COVID; PASC

Online: 26 March 2024 (03:05:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1019.v1

Metabolite Profiling of Allium hookeri Leaves using UPLC-qTOF-MS/MS and Senomorphic Activity of Phenolamides

Thi-Phuong Doan, Mi Zhang, Jin-Pyo An, Jorge-Eduardo Ponce-Zea, Van-Hieu Mai, Byeol Ryu, Eun Jin Park, And Won-Keun Oh

Subject: Biology And Life Sciences, Aging Keywords: Allium hookeri; N-trans-feruloyltyramine; senomorphic effect; SASP inhibitor

Online: 17 October 2023 (08:12:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0710.v1

The Role of the Thyroid Disease and Other Biomarkers in Invasive Breast Cancer. 3-Year Retrospective Comparative Study

Alexandrina Nikova, Vasilios Tselepidis, Loukas Karelis, Christos Valavanis, Pinelopi Vlotinou, Helena Michalopoulou, Anna Tsiakiri, Nikolaos Konsolakis, Maria Kyriazi

Subject: Medicine And Pharmacology, Surgery Keywords: thyroid disease; breast cancer; thyroid hormones; TNM; Calcium

Online: 9 August 2024 (12:08:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201610.0074.v1

Novel Step-up DC-to-DC Converter with Isolated Transformer and Switched-Clamp Capacitor Techniques for Renewable Systems

Yong-Seng Wong, Jiann-Fuh Chen, Kuo-Bin Liu

Subject: Engineering, Electrical And Electronic Engineering Keywords: high voltage gain; switch-clamp capacitor; DC–DC converter; renewable energy

Online: 18 October 2016 (09:45:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0354.v1

Eco-Physiological and Genetic Basis of Drought Response Index in Rice – Integration Using a Temperate Japonica Mapping Population

Poornima Ramalingam, An Thi Ha Nguyen, Akihiko Kamoshita

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: rice (Oryza sativa); drought recovery; drought tolerance; QTL by environment interaction

Online: 6 August 2024 (09:10:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.2148.v1

Assessment of Knowledge, Attitude and Practice of Accessing Healthcare Services at the University Health Clinic among the Students of David Umahi Federal University of Health Sciences (Dufuhs), Uburu

Princess Ngene, Ignatius Ogbaga

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: healthcare; clinic; Likert scale; DUFUHS; school health

Online: 31 May 2024 (13:28:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0819.v1

Comparing the Impact of Low Frequency vs High Frequency Deep Brain Stimulation in Patients with Parkinson’s Disease: A Systematic Review

Govind Singh Mann, Sanam Wasim Khan, Thrinatha Movva, Abdalla Malik, Leeda Ahmadi, MD Parbej Allam, Binay Panjiyar

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Parkinson’ s disease; deep brain stimulation; neurology; neuro-degenerative diseases

Online: 12 August 2024 (13:43:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0015.v1

Comparative Study of Two Decision-Making Measures: The Melbourne Decision-Making Questionnaire Versus the General Decision-Making Style

Anton Aluja, Ferran Balada, Luis F. García, Oscar Garcia

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Decision making; convergence validity; MDMQ; GDMS

Online: 1 July 2024 (09:13:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1755.v1

Neuregulin 2 Is a Candidate Gene for Autism Spectrum Disorder

Wei-Hsien Chien, Chia-Hsiang Chen, Min-Chih Cheng, Yu-Yu Wu, Susan Shurfen Gau

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: autism spectrum disorders; neuregulin 2 (NRG2); insertion/deletion polymorphism (indel)

Online: 28 March 2024 (10:52:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.0775.v1

Kinetic Studies on the Interaction of HIV-1 Gag Protein with the HIV-1 RNA Packaging Signal

Constance Rink, Tomas Kroupa, Siddhartha A.K. Datta, Alan Rein

Subject: Biology And Life Sciences, Virology Keywords: HIV-1; packaging signal; Psi; protein-RNA interactions; binding kinetics

Online: 12 August 2024 (10:45:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1611.v1

The “Other” Workplace Design Factors: An Insight into What New Zealand Workers Want

James Olabode Bamidele Rotimi, Eziaku Onyeizu Rasheed

Subject: Engineering, Architecture, Building And Construction Keywords: Diversity and inclusion; Facilities; Office design; Performance; Productivity; Sustainability

Online: 22 August 2024 (08:26:03 CEST)

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The recent COVID-19 pandemic has led to a reassessment of workplace necessities. It has resulted in the current shift from traditional workplace design to creating work experiences - a new par-adigm in workplace management. Hence, while some conventional workplace factors remain important to the experiences of workers and, thus, to their well-being, comfort and productivity, recent studies suggest other factors, not widely known, as important in creating the appropriate work experience. Our study explores these other factors in the workplace that contribute to, or may be very important to, workers’ comfort, well-being and productivity. These include working mode, facilities, sustainability practices and Diversity, Equity, and Inclusion (DEI) – cultural connection. A sample of 149 occupants across offices in New Zealand was conveniently collected for the study and analysed using descriptive and content analysis in SPSS vs 24. The results show that the occupants prefer to have private offices in the workplace and separate meeting rooms for better concentration on work. In terms of working mode, a combined model of remote working and in-office working is preferred. Furthermore, occupants prefer to have access control and fire safety systems essentially in the workplace and for their offices to be cleaned daily. For sustainable measures in the workplace, the respondents choose the following as practical and convenient: turning off computers outside work hours, using more LED light bulbs in the office, opening windows and doors when required and using a motion sensor lighting system. Interestingly, most of the respondents did not think having a cultural connection in their workplace was important. The study findings represent significant progress in identifying the needs of contemporary office workers. These findings assist facility managers and workplace designers in developing more proactive approaches to anticipated user issues in buildings.

Preprint ARTICLE | doi:10.20944/preprints202408.1258.v1

Explaining Clusters in RDF Datasets: Computational Aspects

Francesco M Donini, Simona Colucci, Eugenio Di Sciascio

Subject: Computer Science And Mathematics, Information Systems Keywords: Clusterization; Explanation in Artificial Intelligence (XAI); Least Common Subumer (LCS); RDF

Online: 16 August 2024 (17:09:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0644.v1

Deep Unfolded Tikhonov Regularized Conjugate Gradient Algorithm for MIMO Detection

Sümeye Nur Karahan, Aykut Kalaycıoğlu

Subject: Engineering, Telecommunications Keywords: MIMO detection; Tikhonov regularization; conjugate gradient; deep learning; wireless communication

Online: 9 August 2024 (07:33:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0874.v1

Image Databases with Features Augmented with Singular Point Shapes for Enhanced Machine Learning

Nikolay Metodiev Sirakov, Adam Bowden

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Image; Vector Field; Features; Augmentatiion; Classification; Machine Learning

Online: 11 July 2024 (05:14:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0238.v1

Brezis-Nirenberg type critical problems on H-type groups

Jialin Wang, Shuijin Zhang, Dongni Liao

Subject: Computer Science And Mathematics, Mathematics Keywords: CR Yamabe problem; Brezis-Nirenberg problem; Folland-Stein inequality; H-type group

Online: 5 June 2024 (10:46:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1954.v1

Symptoms of Digital Addiction of Estonian Primary School Students

Riin Seema, Johanna Väljas, Piret Oppi

Subject: Social Sciences, Education Keywords: Symptoms of digital addiction; screen time; school burnout; refreshed from sleep in the morning

Online: 29 May 2024 (12:17:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0201.v2

What is the “Hydrogen Bond”? A QFT-QED Perspective

Paolo Renati, Pierre Madl

Subject: Biology And Life Sciences, Biophysics Keywords: quantum field theory; phase; coherence; water; symmetry-breaking; dynamical order; resonance; non-thermal effects; Hydrogen bond

Online: 8 March 2024 (09:59:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1204.v1

Extending Fraud Detection in Students Exams Using AI

Georgi Cholakov, Asya Stoyanova-Doycheva

Subject: Computer Science And Mathematics, Information Systems Keywords: e-learning; software agents; fraud detection; artificial intelligence; ChatGPT

Online: 22 February 2024 (01:22:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1004.v1

A Comprehensive State-of-the-Art Survey on Green Hydrogen Economy in Sub-Saharan Africa

Gideon Ude Nnachi, Coneth Graham Richards, Yskandar Hamam

Subject: Engineering, Energy And Fuel Technology Keywords: Climate Change; Electrolysis; Fossil Fuels; Global Warming; Green Energy Production; Hydrogen Fuel Cell Vehicles; Hydrogen Storage Systems; Renewable Energy Sources; Sustainable Development Goals

Online: 19 February 2024 (16:10:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0589.v2

Revisiting the use of the Gumbel distribution: A Frequency Analysis Perspective

Cristian-Gabriel Anghel

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Gumbel; parameter estimation; variability; theoretical bias; frequency analysis.

Online: 26 February 2024 (12:31:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints201610.0134.v1

Prediction of Rice Water Requirement Using FAO-CROPWAT Model in North Iran under Future Climate Change

Javad Gilanipour, Bahram Gholizadeh

Subject: Environmental And Earth Sciences, Environmental Science Keywords: rice; water requirement; climate change; Penman-Monteith; CROPWAT

Online: 31 October 2016 (03:21:42 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202405.2167.v1

Adult-Onset Systemic Chronic Active Epstein - Barr virus Disease: A Case Report Highlighting Unique Immunophenotype and Novel Molecular Insights in the Context of Chronic HBV Hepatitis

Tulasi Geevar, Peter JB Sabatini, Tong Zhang, Ali Sakhdari

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: chronic EBV infection; T cell lymphoproliferative disorder; mutational profile

Online: 3 June 2024 (07:58:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2475.v1

EEG for Neurological Prognostication in Post-anoxic Coma Following Cardiac Arrest and Its Relationship to Outcome

Zaitoon Shivji, Nathaniel Bendahan, Carter McInnis, Timothy Woodford, Michael Einspenner, Lisa Calder, Lysa Boissé Lomax, Garima Shukla, Gavin Paul Winston

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Cardiac arrest; electroencephalography; anoxic coma; prognosis

Online: 30 July 2024 (16:57:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1218.v1

Preprocessing of Iris Images for BSIF-Based Biometric Systems: Binary Detected Edges and Iris Unwrapping

Arthur Rubio, Baptiste Magnier

Subject: Computer Science And Mathematics, Signal Processing Keywords: Iris Biometric Recognition; Image Preprocessing; Canny Algorithm; Iris Unwrapping; Binarized Statistical Image Features; Hough Transform; Computer Vision

Online: 18 June 2024 (11:20:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.1319.v1

Trackerless 3D Freehand Ultrasound Reconstruction: A Review

Chrissy Adriaans, Mark Wijkhuizen, Lennard van Karnenbeek, Freija Geldof, Behdad Dashtbozorg

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Freehand ultrasound; 3D reconstruction; Deep learning; Inertial measurement units (IMUs)

Online: 20 August 2024 (10:40:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0101.v1

Measuring the influence of key management decisions on the nitrogen nutritional status of annual ryegrass-based forage crops

Luís Silva, Sofia Barbosa, Fernando Cebola Lidon, José Santos-Silva, Luís Alcino Conceição

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: critical nitrogen concentration; data-driven approach; crop yield; site-specific analysis; sustainability; variable rate fertilisation.

Online: 1 July 2024 (12:55:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1929.v1

Application of Transcriptome–Based Gene Set Featurization for Machine Learning Model to Predict the Origin of Metastatic Cancer

Yeon Uk Jeong, Jinah Chu, Juwon Kang, Seungjun Baek, Jae Hak Lee, Dong Sub Jung, Won Woo Kim, Yi Rang Kim, Ji Hoon Kang, In-gu Do

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Cancer of Unknown Primary; Metastatic Cancer; Machine Learning; Gene Expression; Transcriptome

Online: 29 May 2024 (08:31:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0820.v1

Establishing the Characteristic Compressive Strength Parallel to Fiber of Four Local Philippine Bamboo Species

Christine Abegail Tomagan Panti, Christy Sapois Cañete, Althea Roylo Navarra, Kerby Dianela Rubinas, Lessandro Estelito Ortega Garciano, Luis Felipe López

Subject: Engineering, Architecture, Building And Construction Keywords: Bambusa vulgaris; Dendrocalamus asper; Bambusa blumeana; Guadua angustifolia Kunth; characteristic compressive strength; ISO 22157-1; ISO 12122-1

Online: 14 March 2024 (08:08:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0326.v2

Modulation of Corticospinal Excitability during Action Observation in Patients with Consciousness-Related Disturbances

Mauro Mancuso, Lucia Mencarelli, Laura Abbruzzese, Benedetta Basagni, Pierluigi Zoccolotti, Cristiano Scarselli, Simone Capitani, Francesco Neri, Emiliano Santarnecchi, Simone Rossi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Disorders of consciousness; minimally consciousness state; vegetative state/unresponsiveness wakefulness syndrome; transcranial magnetic stimulation; action observation

Online: 9 April 2024 (16:50:02 CEST)

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Brain imaging studies have recently provided some evidence in favour of covert cognitive processes ongoing in patients with disorders of consciousness (DoC) (e.g., minimally consciousness states, vegetative state/unresponsive wakefulness syndrome) engaged in passive sensory stimulation or active tasks such as motor imagery. In this exploratory study, we used transcranial magnetic stimulation (TMS) of the motor cortex to assess modulations of corticospinal excitability induced by action observation in eleven patients with DoC. Action observation is known to facilitate corticospinal excitability in healthy subjects, unveiling how the observer’s motor system maps others’ actions onto her/his motor repertoire. Additional stimuli were non-biological motion and acoustic startle stimuli, provided that sudden and loud acoustic stimulation is known to lower corticospinal excitability in healthy subjects. Results indicate that some form of motor resonance is spared in a subset of patients with DoC with some significant difference between biological and non-biological motion stimuli. However, there was no covariation between corticospinal excitability and the type of DoC diagnosis (i.e., whether VS/UWS or MCS). Similarly, no covariation was detected with clinical changes between admission and discharge in clinical outcome measures. Both motor resonance and biological/non-biological motion discrimination correlated with the amplitude of the N20 somatosensory evoked potentials following the stimulation of the median nerve at the wrist (i.e., the temporal marker signalling the activation of the contralateral primary somatosensory cortex). Moreover, the startle-evoking stimulus produced an anomalous increase in corticospinal excitability, suggesting a functional dissociation between cortical and subcortical circuits in patients with DoC. Further work is needed to better comprehend the conditions in which corticospinal facilitation occurs and whether and how they may relate to individual clinical parameters.

Preprint REVIEW | doi:10.20944/preprints202401.1997.v2

The congestion “Pandemic” in Acute Heart Failure Patients

Daniela Mocan, Radu Ioan Lala, Maria Puschita, Luminita Pilat, Dan Alexandru Darabantiu, Adina Pop Moldovan

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart failure; congestion; volume overload; volume redistribution; biomarkers

Online: 5 March 2024 (05:55:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1732.v1

ResNet152-U-Net: Transfer Learning for the Semantic Segmentation of Forest Restoration Site Using Aerial Images

Eunhee Son, Ui Rin Ha, Hojin Seong, Yoonsun Park, Jungeun Song, Hyungho Kim

Subject: Biology And Life Sciences, Forestry Keywords: semantic segmentation; forest restoration; aerial images; deep learning; convolutional neural network; U-Net

Online: 29 February 2024 (12:56:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.2269.v1

Probabilistic Power and Energy Balance Risk Scheduling Method Based on Distributed Robust Optimization

Jing Shi, Jianru Qin, Haibo Li, Zesen LI, Yi GE, Boliang LIU

Subject: Engineering, Electrical And Electronic Engineering Keywords: electric power and energy balance; distributionally robust optimization; probabilistic index; affine factor; flexible climbing reserve

Online: 2 September 2024 (11:13:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.2024.v1

Strategies to Delay Ethylene-Mediated Ripening in Climacteric Fruits: Implications for Shelf-Life Extension and Postharvest Quality

Alonso-Salinas Ramiro, López-Miranda Santiago, López-Pérez Antonio José, Acosta-Motos José Ramón

Subject: Biology And Life Sciences, Food Science And Technology Keywords: delayed ripening; climacteric fruit; fruit preservation; phytohormone

Online: 29 June 2024 (05:31:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints201701.0039.v1

Curcumin a Multifaceted Compound with Hormetic Behaviour that Mediates an Intricate Crosstalk between Mitochondrial Biogenesis, Mitophagy, Mitophagic Death and Apoptosis

Nathan Earl Rainey, Aoula Moustapha, Raphaelle Parker, Patrice Xavier Petit

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: apoptosis; autophagy; cancer; crosstalk; curcumin; endoplasmic reticulum; hormatic behavior; lysosomes; mitochondria

Online: 10 January 2017 (03:46:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.1178.v1

Land use change scenarios building combining agricultural development policies, landscape planning approaches and ecosystem services assessment. The Campania Region (Italy) case-study

Elena Cervelli, Pier Francesco Recchi, Ester Scotto di Perta, And Stefania Pindozzi

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Land-use change; Land-use planning; Ecosystem services; Erosion; Climate change; Agricultural policies; Soil tillage

Online: 18 July 2023 (07:40:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1199.v1

Application of Isokinetic Dynamometry Data in Predicting Gait Deviation Index Using Machine Learning in Stroke Patients

Xiaolei Lu, Chenye Qiao, Hujun Wang, Yingqi Li, Congxiao Wang, Yingpeng Wang, Shuyan Qie

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Isokinetic Dynamometry; Gait Deviation Index; Machine Learning; Stroke

Online: 19 August 2024 (17:56:16 CEST)

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Background: Three-dimensional gait analysis plays a crucial role in the rehabilitation assessment of post-stroke hemiplegic patients. However, the data generated from such analysis is often complex and difficult to interpret in clinical practice, requiring extensive time and complicated procedures. The Gait Deviation Index (GDI) serves as a simplified metric for quantifying the severity of pathological gait. Although isokinetic dynamometry is widely employed in muscle function assessment and rehabilitation, its application in gait analysis remains underexplored. Objective: This study aims to investigate the use of isokinetic muscle strength data obtained from the Biodex system, combined with machine learning techniques, to predict the GDI in hemiplegic patients. Methods: A cohort of 150 post-stroke hemiplegic patients was evaluated. The peak torque, peak torque/body weight, maximum work of repeated actions, coefficient of variation, average power, total work, acceleration time, deceleration time, range of motion, and average peak torque for both flexor and extensor muscles on the affected side were measured at three angular velocities (60°/s, 90°/s, and 120°/s) using the Biodex System 4 Pro. GDI was calculated using data from a Vicon three-dimensional motion capture system. The study employed four machine learning models—Lasso regression, random forest (RF), support vector regression (SVR), and BP neural networks—to model and validate the data. Model performance was evaluated using mean squared error (MSE), the coefficient of determination (R²), and mean absolute error (MAE). SHapley Additive exPlanations (SHAP) analysis was used to enhance model interpretability. Results: The RF model outperformed others in predicting GDI, with an MSE of 16.18, an R² of 0.89, and an MAE of 2.99. In contrast, the Lasso regression model yielded an MSE of 22.29, an R² of 0.85, and an MAE of 3.71. The SVR model had an MSE of 31.58, an R² of 0.82, and an MAE of 7.68, while the BP neural network exhibited the poorest performance with an MSE of 50.38, an R² of 0.79, and an MAE of 9.59. SHAP analysis identified the maximum work of repeated actions of the extensor muscles at 60°/s and 120°/s as the most critical features for predicting GDI, underscoring the importance of muscle strength metrics at varying speeds in rehabilitation assessments. Conclusion: This study highlights the potential of machine learning techniques in analyzing complex clinical data. The developed GDI prediction model, based on isokinetic dynamometry data, offers a novel, streamlined, and effective tool for assessing rehabilitation progress in post-stroke hemiplegic patients, with promising implications for broader clinical application.

Preprint ARTICLE | doi:10.20944/preprints202405.1532.v1

Microbial Communities Associated with the Intestinal Tract of Grey Mullets from a Mediterranean Aquatic Environment

Rosanna Floris, Gabriele Sanna, Satta Cecilia Teodora, Greta Battaggia, Fabio De Pascale, Alessandro Vezzi, Nicola Fois

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: microbiome; ecosystem; Mugilidae; 16S barcode; bioremediation; fish gut; aquaculture

Online: 23 May 2024 (12:36:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0820.v1

Questionnaire-Based Investigation of COVID-19 Vaccine Hesitancy among Omani Parents in the Outpatient Pediatric Departments of Sultan Qaboos University Hospital: A Cross-Sectional Study

Moataz mohamed Hassan, Laila S Al Yazidi, Nagi Elsidig, Mohamed Al Falahi, Najah Al-salmi, Yahya Al-Jaffari, Labiba Al-Amri, Hiam Zeidan, Ibrahim Al-Zakwani

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: vaccine hesitancy; children; COVID-19; SARS-CoV-2; Oman

Online: 14 February 2024 (15:25:12 CET)

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Preprint REVIEW | doi:10.20944/preprints201612.0113.v1

Breast Cancer Brain Metastases: Clonal Evolution in Clinical Context

Jodi M. Saunus, Amy E. McCart Reed, Zhun Leong Lim, Sunil R. Lakhani

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: breast cancer; brain metastases; clonal evolution; precision medicine; genomics; tumour microenvironment

Online: 22 December 2016 (09:57:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.1063.v1

Novel OCT-Based Method to Measure Volumes of Retinal Specific Entities

Myrta Lippera, Mariantonia Ferrara, Karina Spiess, Nouf Alnafisee, Naseer Ally, Assad Jalil, Tsveta Ivanova, George Moussa

Subject: Medicine And Pharmacology, Ophthalmology Keywords: retinal volume; Spectralis (Engineering GmbH, Heidelberg, Germany); optical coherence tomography (OCT); volumetric analysis; retina

Online: 17 June 2024 (08:44:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1947.v1

Optimizing Fatigue Performance in Gradient Structural Steels by Manipulating Grain Size Gradient Rate

Meichen Pan, Xin Chen, Meiling He, Yi Kong, Yong Du, Alexander Hartmaier, Xiaoyu Zheng, Yuling Liu

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: gradient structural steel; gradient rate; fatigue; crack propagation

Online: 29 May 2024 (11:00:12 CEST)

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Preprint ESSAY | doi:10.20944/preprints202403.1503.v1

Identifying Features of a System of Practice to Inform a Contemporary Competency Framework for Paramedics in Canada

Alan M Batt, Meghan Lysko, Jennifer L Bolster, Pierre Poirier, Derek Cassista, Michael Austin, Cheryl Cameron, Elizabeth A. Donnelly, Becky Donelon, Noel Dunn, William Johnston, Chelsea Lanos, Tyne M Lunn, Paige Mason, Sean Teed, Charlene Vacon, Walter Tavares

Subject: Public Health And Healthcare, Health Policy And Services Keywords: systems thinking; paramedicine; Canada; paramedic practice; competency

Online: 26 March 2024 (12:57:57 CET)

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Introduction Paramedic practice is highly variable, occurs in diverse contexts, and involves the assessment and management of a range of presentations of varying acuity across the lifespan. As a result, attempts to define paramedic practice have been challenging and incomplete. This has led to inaccurate or under-representations of practice that can ultimately affect education, assessment, and the delivery of care. In this study, we outline our efforts to better identify, explore, and represent professional practice when revising a national competency framework for paramedics in Canada. Methods We used a systems thinking approach to identify the settings, contexts, features, and influences on paramedic practice in Canada. This approach makes use of the role and influence of system features at the microsystem, mesosystem, exosystem, macrosystem, supra-macro system, and chronosystem levels in ways that can provide new insights. We used methods such as rich pictures, diagramming, and systems mapping to explore relationships between these contexts and features. Findings When we examine the system of practice in paramedicine, multiple layers become evident and within them we start to see details of features that ought to be considered in any future competency development work. Our exploration of the system highlights that paramedic practice considers the person-receiving care, caregivers, and paramedics. It involves collaboration within co-located and dispersed teams that are composed of other health and social care professionals, public safety personnel, and others. Practice is enacted across varying geographical, cultural, social, and technical contexts, and is subject to multiple levels of policy, regulatory, and legislative influence. Conclusion Using a systems thinking approach, we developed a detailed systems map of paramedic practice in Canada. This map can be used to inform the initial stages of a more representative, comprehensive, and contemporary national competency framework for paramedics in Canada.

Preprint REVIEW | doi:10.20944/preprints202402.0764.v1

Biomarkers in Contrast-Induced Acute Kidney Injury: Towards a new perspective.

María Ángeles González-Nicolás, Cristian González-Guerrero, Marian Goicoechea, Lisardo Boscá, Lara Valiño-Rivas, Alberto Lázaro

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Contrast-Induced Acute Kidney Injury; Biomarkers; Contrast Media; Nephrotoxicity

Online: 14 February 2024 (09:32:46 CET)

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Preprint REVIEW | doi:10.20944/preprints202409.0165.v1

Interactions between Forest Cover and Watershed Hydrology: A State-of-the-Art Review

Mathurin François, Terencio Rebello de Aguiar Junior, Marcelo Schramm Mielke, Alain N. Rousseau, Deborah Faria, Eduardo Mariano-Neto

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Erosion; forest age; forest hydrology; runoff; soil water infiltration; water cycle

Online: 3 September 2024 (08:05:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1128.v1

Trends and Environmental Drivers of Marine Fish Landings in Cuba’s Most Productive Shelf Area

Yunier Olivera-Espinosa, Yandy Rodríguez-Cueto, Fabián Pina-Amargós, Francisco Arreguín-Sánchez, Manuel J. Zetina-Rejón, Kendra Karr, Pablo del Monte-Luna

Subject: Environmental And Earth Sciences, Environmental Science Keywords: fisheries; fishing effort; overfishing; landings per unit of effort; Atlantic Multidecadal Oscillation; dynamic factor analysis

Online: 17 May 2024 (12:56:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202005.0376.v1

Computational Strategies to Combat COVID-19: Useful Tools to Accelerate SARS-CoV-2 and Coronavirus Research

Franziska Hufsky, Kevin Lamkiewicz, Alexandre Almeida, Abdel Aouacheria, Cecilia Arighi, Alex Bateman, Jan Baumbach, Niko Beerenwinkel, Christian Brandt, Marco Cacciabue, Sara Chuguransky, Oliver Drechsel, Robert D. Finn, Adrian Fritz, Stephan Fuchs, Georges Hattab, Anne-Christin Hauschild, Dominik Heider, Marie Hoffmann, Martin Hölzer, Stefan Hoops, Lars Kaderali, Ioanna Kalvari, Max von Kleist, René Kmiecinski, Denise Kühnert, Gorka Lasso, Pieter Libin, Markus List, Hannah F. Löchel, Maria J. Martin, Roman Martin, Julian Matschinske, Alice C. McHardy, Pedro Mendes, Jaina Mistry, Vincent Navratil, Eric Nawrocki, Áine Niamh O'Toole, Nancy Palacios-Ontiveros, Anton I. Petrov, Guillermo Rangel-Piñeros, Nicole Redaschi, Susanne Reimering, Knut Reinert, Alejandro Reyes, Lorna Richardson, David L. Robertson, Sepideh Sadegh, Joshua B. Singer, Kristof Theys, Chris Upton, Marius Welzel, Lowri Williams, Manja Marz

Subject: Biology And Life Sciences, Virology Keywords: virus bioinformatics; SARS-CoV-2; sequencing; epidemiology; drug design; tools

Online: 23 May 2020 (11:01:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0768.v1

Design and Modelling of MEMS Vibrating Internal Ring Gyroscopes for Harsh Environments

Waqas Amin Gill, Ian Howard, Ilyas Mazhar, Kristoffer McKee

Subject: Engineering, Mechanical Engineering Keywords: MEMS vibrating ring gyroscope; inertial sensors; harsh environments; mode matching; space applications; inertial measurement unit (IMU); ring resonator

Online: 10 July 2024 (09:53:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1997.v1

Evidence for a Giant Magneto-Electric Coupling in Bulk Composites with Coaxial Nanofibers of Nickel Zinc Ferrite and PZT

Bingfeng Ge, Jitao Zhang, Sujoy Saha, Sabita Acharya, Chaitrali Kshirsagar, Sidharth Menon, Menka Jain, Michael R. Page, Gopalan Srinivasan

Subject: Chemistry And Materials Science, Electronic, Optical And Magnetic Materials Keywords: Ferrite; Ferroelectric; PZT: Nanofiber; Direct Magnetoelectric Effects

Online: 28 June 2024 (05:13:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1442.v1

Cross-Sectional Study of Factors Predicting the Duration of Efficacy of Viscosupplementation in Knee Osteoarthritis

Charles Rapp, Feriel Boudif, Charlotte Bourgoin, Anne Lohse, Thierry Conrozier

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Hyaluronic acid; viscosupplementation; knee, osteoarthritis; effectiveness; predictors; ;

Online: 26 February 2024 (11:49:00 CET)

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BackgroundAdvanced radiological stage of knee osteoarthritis (OA) and obesity are predictive of poorer and shorter response to viscosupplementation, but very few is known regarding the impact of other factors such as sport practice, comorbidities or anatomical features of OA. ObjectivesTo investigate the patient’s and OA characteristics associated with the duration of effectiveness (DE) of viscosupplementation in patients with knee OA.MethodsCross-sectional single center trial in patients with knee OA treated with intra-articular (IA) hyaluronic acid (HA) injection(s) within the previous 3 years. The investigator collected demographic and radiographic data (Kellgren grade, involved knee compartments), dosing regimen (single or repeat injections), presence and volume of joint effusion, previous or concomitant IA corticosteroid injection, number of previous viscosupplémentations and the comorbidities. The patient completed a questionnaire including the self-assessment of DE (number of weeks during which viscosupplementation was effective on symptoms), the activity level (sedentary, active, athletic), the level of sport activity (light, moderate or intensive). Predictors of DE were studied in univariate and multivariate analyses ResultsOne hundred five patients (149 knees) were analyzed (62% women, mean age 66.1 ± 13.2 years, mean BMI 27.5 ± 7.5 kg/m²). The mean DE was 48.2 + 24.8 weeks. In a bivariate analysis, the predictors of a shorter with DE were BMI >27.5kg/m2, more than 3 previous viscosupplémentations, Kellgren grade 4, sedentary patients, and more than 1 affected compartment. In the multivariate analysis, 4 independent factors remained associated with a shorter DE: BMI >27.5 kg/m2, knee multi-compartment damage, number of viscosupplements >3, sedentary lifestyle. A statistically significant association between a longer DE and treated arterial hypertension was found suggesting a beneficial effect of certain antihypertensive drugs. ConclusionThe study confirms the harmful influence of an increased BMI, It also shows that viscosupplementation is more effective in unicompartmental OA. Other points worth highlighting are the reduction in the duration of efficacy with repeated cycles of injections and the benefit of a regular physical activity.

Preprint ARTICLE | doi:10.20944/preprints202407.0986.v1

Enhanced Medical Data Extraction: Leveraging LLMs for Accurate Retrieval of Patient Information from Medical Reports

Angel M Garcia-Carmona, Maria-Lorena Prieto, Enrique Puertas, Juan-Jose Beunza

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Large Language Models; Langchain framework; Electronic Health Records; Data mining; Model Evaluation; Healthcare; Digitalization

Online: 12 July 2024 (02:58:16 CEST)

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