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Preprint CASE REPORT | doi:10.20944/preprints201608.0094.v1

Brain Biomarkers of Long-term Outcome of Neonatal Onset Urea Cycle Disorder

Maha Mourad, Johannes Häberle, Matthew Whitehead, Tamar Stricker, Andrea L. Gropman

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: urea cycle disorder; ornithine transcarbamylase deficiency; magnetic resonance imaging; magnetic resonance spectroscopy

Online: 9 August 2016 (12:03:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0464.v1

Evaluation of Psychosomatic, Respiratory, and Neurocognitive Health in COVID-19 Survivors 12 Months after ICU Discharge

Nicolas Germann, Daria Amozova, Kristina Göhl-Freyn, Tim Fischer, Manuel Frischknecht, Gian-Reto Kleger, Urs Pietsch, Miodrag Filipovic, Martin H. Brutsche, Thomas Frauenfelder, Christian R. Kahlert, Dagmar A. Schmid, Werner C. Albrich

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: COVID-19; Intensive Unit Care; ICU; Predictive Model; Psychosomatic Health

Online: 5 July 2024 (00:23:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0112.v1

Computational Elucidation of Human β-defensin-2 as a Dual Inhibitor of MMP-9 and PKC-βII for Diabetic Wound Management

Vidyasrilekha Sanapalli, Dilep Kumar. Sigalapalli, Afzal B. Shaik, Richie R. Bhandare, Bharat Kumar Reddy Sanapalli

Subject: Medicine And Pharmacology, Dermatology Keywords: Diabetic wound; Human β -defensin-2; Matrix metalloproteinase-9; Protein kinase C-β II; Protein-protein docking; Molecular dynamics simulation studies

Online: 2 September 2024 (13:35:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0104.v1

A Comprehensive View of Expression Profiles Dynamics of Capsaicinoid Biosynthesis-Related Genes during Pepper Fruit Development and under MeJA Treatment

Minghua Deng, Jinfen Wen, Kai Zhao, Jinlong Huo, Zhuqing Zhang, Haishan Zhu, Xuexiao Zou

Subject: Biology And Life Sciences, Horticulture Keywords: Capsicum annuum L.; capsaicinoid synthesis; gene expression; fruit development; MeJA

Online: 10 August 2016 (10:11:50 CEST)

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Background: Capsaicinoid are a group of compounds and widely used in the food, medical, and pharmaceutical industries. Capsaicinoid are unique synthesized and accumulated in the pepper fruits. MeJA can enhance the capsaicinoid production. Temporal and spatial expression of capsaicinoid biosynthetic genes are helpful to understand the molecular mechnism of capsaicinoid biosynthesis in the fruits of pepper. Although some of the capsaicinoid biosynthetic genes in pepper have been identified, the expression of these genes at different developing stages of fruit has not been systemically investigated, and little is known about the molecular basis of MeJA inducing capsaicinoid biosynthesis. Results: HPLC study revealed that the capsaicinoid accumulation in the developing fruit of pepper initially appeared at 24 DAP (day after pollination), was actively development at 36 DAP and peaked at 48 DAP. 11 genes that encoded enzymes involved in capsaicinoid biosynthesis were isolated and characterized. Gene expression with quantitative reverse-transcription polymerase chain reaction analysis demonstrated that the CaCS was unique expressed in placenta and the other 10 genes were expressed in all selected tissues and 9 of 11 genes (except CaCa4H and CaCa3H) were strongly expressed in placenta tissue. Spatial expression analysis demostrated that the 11 gene could be collectively grouped into four categories based on the patterns of relative expression of the genes during fruit development. Category I has 2 and they displayed a bell-shaped expression pattern with the peak expression at 24 DAP, Category II contains 5 genes and expression of the 5 genes was constantly increased from 0 to 36 DAP and peaked at 36 DAP. Category III comprises of 2 genes and both genes reached the peak at 48 DAP. Category IV consists of 2 genes and they showed a high expression at 36 and 48 DAF, but unexpressed from 0 to 12 DAP. The gene expressions of the 11 genes were up-regulated by MeJA. 3 genes showed a high expression at 24 h; 4 genes reached the peak at 12 h; the top expression were observed at 18 h; The last one, CaACYase, achieved the highest level at 8 h. Conclusion: The biosynthesis of capsaicinoid in pepper fruit is developmentally regulated. The expression of the majority of capsaicinoid biosynthetic genes is highly consistent with the development accumulation of capsaicinoid in pepper fruit. These results not only provide the initial information on spatial and temporal expression of capsaicinoid biosynthetic genes in pepper developing fruit, but are also valuable to identify the MeJA-induced genes for capsaicinoid biosynthesis and accumulation during pepper fruit development.

Preprint REVIEW | doi:10.20944/preprints202406.1580.v1

The Indispensable Role of Bacteria in Human Life and Environmental Health

PD Gupta, Dominika Skiba, Barbara Sawicka

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: bacteria; human health; microbiome; gut microbiome; probiotics; environmental bacteria; fecal microbiota transplantation (FMT); ecosystems; nutrient cycling; immune system.

Online: 24 June 2024 (12:23:42 CEST)

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Background: Bacteria, among the earliest life forms on Earth, are integral to both human health and environmental ecosystems. They contribute to essential processes such as digestion, nutrient absorption, and immune defense, and play key roles in the biogeochemical cycles that sustain life. Objective: This paper explores the indispensable role of bacteria in human life and environmental health, emphasizing their contributions to digestion, nutrient absorption, immune protection, and ecosystem functioning. It also discusses advances in understanding the human microbiome and their implications for health and therapeutic interventions. Methods: The study reviews existing literature on the human microbiome, probiotics, and the role of bacteria in environmental nutrient cycling. It analyses experimental evidence and case studies, particularly focusing on the impact of fecal microbiota transplantation (FMT) as a therapeutic tool. Metagenomic analysis techniques are examined to highlight the diversity and functionality of gut bacteria. Results: Bacteria are found to be essential for breaking down food, providing vital nutrients, and protecting against pathogens. They play a critical role in maintaining a healthy immune system and are involved in the biogeochemical cycles necessary for ecosystem health. Metagenomic analysis reveals significant variations in bacterial populations associated with health and disease, emphasizing the importance of a balanced microbiota. FMT shows promise as an effective treatment for various diseases, including gastrointestinal, metabolic, and neurological disorders. Conclusions: Bacteria are crucial for human health and environmental stability. Maintaining a balanced microbiota is vital for overall well-being, and interventions such as probiotics and FMT can offer significant health benefits. Future research should focus on further understanding the complex interactions between bacteria and their hosts to develop targeted therapies for various health conditions.

Preprint REVIEW | doi:10.20944/preprints201807.0015.v1

El Niño Southern Oscillation (ENSO) and Health: An Overview for Climate and Health Researchers

Glenn McGregor, Kris Ebi

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: El Niño Southern Oscillation, ENSO, health, climatic variability, climate-sensitive disease

Online: 2 July 2018 (16:13:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0369.v1

Cancer Screening and Treatment Delays During the COVID-19 Pandemic and the Role of Health Literacy in Care Re-Engagement: Findings from an NCI-Designated Comprehensive Cancer Center Sample

Jessica Keim-Malpass, Rick D. Vavolizza, Wendy F. Cohn, Erin M. Kennedy, Shayna L. Showalter

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Covid-19; health literacy; cancer screening; cancer care; cancer prevention

Online: 25 October 2022 (02:02:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1185.v1

Defence and Protection of the Marine Coastal Areas and Human Health: A Case Study of Asbestos Cement Contamination (Italy)

Roberta Somma, Salvatore Giacobbe, Francesco Paolo La Monica, Maria Letizia Molino, Marina Morabito, Sebastiano Ettore Spoto, Salvatore Zaccaro, Giuseppe Zaffino

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: marine coasts; protected areas; defense and conservation; asbestos cement materials; wastes; contamination; human health risk; medical geology

Online: 21 February 2024 (04:31:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.1793.v1

Advanced HPLC Method with Diode Array Detection Using a Phenyl-Bonded Column for Simultaneous Quantitation of Three Sunscreen Filters in a Moisturizing Sunscreen Cream for Acne-Prone Skin

PANAYIOTIS FEIDIAS, Irene Panderi, GEORGIA ELENI TSOTSOU, IOANNA BALATSOUKA, SPYRIDON PAPAGEORGIOU, ATHANASIA VARVARESOU

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: 4-methylbenzylidene camphor; Enzacamene; Octyl methoxycinnamate; 2-ethylhexyl-4-methoxycinnamate, Avobenzone; Butyl methoxydibenzoylmethane; Cosmetics; Sunscreen; HPLC; Quality Control

Online: 24 September 2024 (05:12:56 CEST)

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This study introduces a novel, robust, and efficient method for the simultaneous quantitative determination of three sunscreen filters namely 4-methylbenzylidene camphor, octyl methoxycinnamate, and avobenzone, in a moisturizing sunscreen cream specifically designed for acne-prone skin. The method employs high performance liquid chromatography with photodiode-array detection, providing reliable separation of the analytes. Chromatographic separation was achieved using a Fortis Phenyl analytical column (150.0 x 2.1 mm, 5 μm), with isocratic elution at a flow rate of 0.4 mL/min. The mobile phase was composed of a 57/43 (v/v) mixture of acetonitrile/45 mM aqueous ammonium formate solution, ensuring sufficient resolution and peak symmetry for the target compounds. The method was validated comprehensively for critical performance parameters, including linearity, precision, accuracy, and robustness. Linearity was established across a suitable range for all three analytes, with high correlation coefficients. Precision was confirmed with intra-run and total precision coefficients of variation of ≤ 4.6 %, while accuracy assessments yielded a percent recovery between 98.6 and 100.4, for all quality control levels. Additionally, the method was able to effectively separate the sunscreen filters from other cosmetic ingredients, such as [β-(1.3), (1.6)-D-glucan], Low Molecular Weight (LMW) hyaluronic acid and plant extracts ensuring specificity in complex formulations. This straightforward and time efficient sample preparation process, involving methanol extraction followed by serial dilution, makes the method suitable for routine quality control in cosmetic laboratories. The method was successfully applied to the analysis of two different lots of a commercial sunscreen cream, achieving excellent recovery for all filters, ranging between 94.6% and 99.8%, thus demonstrating its reliability and applicability for the quality control of cosmetics.

Preprint ARTICLE | doi:10.20944/preprints202409.0662.v2

Integrated Optimization of Large Language Models: Synergizing Data Utilization and Compression Techniques

Xinjin Li, Yu Ma, Yangchen Huang, Xingqi Wang, Yuzhen Lin, Chenxi Zhang

Subject: Computer Science And Mathematics, Computer Science Keywords: Natural Language Processing (NLP); Large Language Models (LLMs); Data Utilization; Model Compression; Knowledge Distillation

Online: 10 September 2024 (14:16:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1948.v1

Prognostication in Epilepsy with Integrated Analysis of Blood Parameters and Clinical Data

Kyung-Il Park, Sungeun Hwang, Hyoshin Son, Jangsup Moon, Soon-Tae Lee, Keun-Hwa Jung, Ki-Young Jung, Kon Chu, Sang Kun Lee

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: epilepsy; outcome; prediction; blood

Online: 27 August 2024 (18:35:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1520.v3

Integrated Method of Deep learning and Large Language Model in Speech Recognition

Bo Guan, Jin Cao, Xingqi Wang, Zhuoyue Wang, Mingxiu Sui, Zixiang Wang

Subject: Computer Science And Mathematics, Computer Science Keywords: deep learning; large language model; speech recognition; ensemble method

Online: 14 August 2024 (07:08:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1575.v1

Stormwater Management: An Integrated Approach to Support Healthy, Livable, and Ecological Cities

Neil Grigg

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: Stormwater; urban planning; green infrastructure sponge cities; integration

Online: 24 June 2024 (08:16:13 CEST)

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The practice of stormwater management has evolved from a singular focus on drainage to a multifaceted approach to support integrated urban development. By contributing to healthy, livable, ecological, and water sensitive cities, it is a key tool to promote Sustainable Development Goal 11 from neighborhood to metropolitan scales. A review of the knowledge base for stormwater management shows several attributes that favor an integrative approach to achieve co-benefits across several sectors. Functional areas of its contributions include drainage, flood control, flood plain management, water quality control, urban ecology, recreation, and city beautification. Legacy path dependance affects the potential to reform land use practices, while stormwater management practice is being affected by climate change, sea level rise, urbanization, inequality, and poor governance. Technical methods for stormwater management are well advanced, but integrative frameworks to address social, ecological and infrastructure needs are more challenging. The sensitivity of ecological issues is most evident in cities in coastal zones. Organizational initiatives are needed to counter neglect of essential maintenance and sustain flood risk reduction in cities. Stormwater management is related to other integrative tools, including IWRM, One Water, One Health, and integrated flood management, as well as the broader concept of urban planning. Stormwater capture and rainfall harvesting offer major opportunities to augment scarce water supplies. Nature-based solutions like low-impact development and the Sponge City concept show promise to transform cities. Major cities face challenges to sustain conveyance corridors for major flows and to store and treat combined sewer runoff. The neighborhood focus of stormwater management elevates the importance of participation and inclusion to advance environmental justice and strengthen social capital. Integrating organizational initiatives from local to city scale and funding improvements to stormwater systems are major challenges that require leadership from higher governance levels, although governments face resistance to change toward integration, especially in countries with poor land use and public works management systems. Finding solutions to neighborhood issues and the connectivity of water systems at larger scales requires complex approaches to urban planning and represent an important agenda for urban and water governance going forward.

Preprint ARTICLE | doi:10.20944/preprints202402.0375.v1

An Integrated Framework with ADD-LSTM and DeepLabCut for Dolphin Behavior Classification

Shih-Pang Tseng, Shao-En Hsu, Jhing-Fa Wang, I-Fan Jen

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: pose estimation; dolphin behavior analysis; LSTM; neural network; image recognition

Online: 6 February 2024 (15:12:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0780.v2

Bistability and Thermal Studies in High Index Doped Silica Integrated Ring Resonators

David Moss

Subject: Engineering, Electrical And Electronic Engineering Keywords: integrated optics; thermo-optic effects; microring resonator; optical bistability

Online: 13 October 2023 (07:53:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0737.v1

Integrated Environmental Design and Robotics Workflow for Double-Skin Facade Perforation Onsite

Ahmed Khairadeen Ali, One Jae Lee

Subject: Engineering, Automotive Engineering Keywords: double-skin facade perforation; environmental design; robotics in construction; VR/AR for monitoring; digital twin in construction

Online: 31 May 2021 (10:42:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0270.v1

MPDB 2.0: A Large Scale and Integrated Medicinal Plant Database of Bangladesh

Nazmul Hussain, Rony Chando, Ruhshan Ahmed Abir, Mohsina Akter Mou, Md. Kamrul Hasan, M. Arif Ashraf

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: MPDB2.0,; medicinal plant; medicinal plant database of Bangladesh; folk medicine

Online: 10 February 2021 (16:29:00 CET)

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Working Paper REVIEW

Versatile Graphene Oxide Films for Ultra-flat Optics and Integrated Photonic Chips

Jiayang Wu, Linnan Jia, Yuning Zhang, Yang Qu, Baohua Jia, David J. Moss

Subject: Physical Sciences, Optics And Photonics Keywords: Graphene oxide; 2D materials; flat optics; integrated photonics

Online: 21 September 2020 (04:23:31 CEST)

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Working Paper ARTICLE

Adaptive Anti-saturation Fault-tolerant Control for Integrated Missile Guidance and Control

Peng Li, Qi Qi Liu, Chenyu He, Xiaoqing Liu

Subject: Engineering, Control And Systems Engineering Keywords: missile guidance and control; dynamic surface control; state constraints; input saturation; actuator faults

Online: 5 May 2020 (11:07:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0258.v1

An Integrated Pan-Cancer Analysis and Structure-Based Virtual Screening of GPR15

Yanjing Wang, Xiangeng Wang, Yi Xiong, Cheng‐Dong Li, Qin Xu, Lu Shen, Aman Chandra Kaushik, Dong-Qing Wei

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: GPR15, pan-cancer, TCGA, cancer immunity, differential gene expression, prognosis, virtual screening

Online: 23 July 2019 (11:15:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0368.v1

Extracellular Hsp70 and Circulating Endometriotic Cells as Novel Biomarkers for Endometriosis

Christiane Guder, Soraya Heinrich, Vanadin Seifert-Klauss, Marion Kiechle, Lisa Bauer, Rupert Öllinger, Andreas Pichlmair, Marie-Nicole Theodoraki, Veena Ramesh, Ali Bashiri Dezfouli, Barbara Wollenberg, Alan Graham Pockley, Gabriele Multhoff

Subject: Medicine And Pharmacology, Reproductive Medicine Keywords: endometriosis; mesenchymal-stemness biomarker; heat shock protein 70 (Hsp70)

Online: 5 September 2024 (02:44:28 CEST)

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The stress-inducible heat shock protein 70 (Hsp70), which functions as a molecular chaperone and is frequently overexpressed in different cancer cell types, is presented on the cell surface of tumor cells and is actively released into the circulation in free and extracellular lipid vesicle-associated forms. Since the exact pathomechanism of endometriosis has not yet been elucidated but has been associated with the development of endometrial and ovarian cancer, we asked whether extracellular Hsp70 and circulating endometriotic cells (CECs) reflects the presence and development of endometriosis. Therefore, circulating levels of free and lipid microvesicle-associated Hsp70 were measured using the Hsp70-exo ELISA, and the presence of circulating CECs in the peripheral blood of patients with endometriosis was determined using membrane Hsp70 (mHsp70) and EpCAM monoclonal antibody (mAb)-based bead isolation approaches. Isolated CECs were further characterized by immunofluorescence using reagents directed against cytokeratin (epithelial), CD45 (leukocyte), CD105/CD44 (mesenchymal-stemness) and by comparative RNA analysis. Similar to the situation in patients with cancer, levels of circulating Hsp70 were elevated in the blood of patients with histologically proven endometriosis compared to a healthy control cohort, with the highest Hsp70 level in a patient with lymph node endometriosis. Moreover, CECs could be isolated using the cmHsp70.1 mAb- and to a lesser extent EpCAM mAb-based bead approaches in all patients with endometriosis. The longevity in cell culture and the expression of cytokeratin, CD105 and CD44, together with differentially expressed genes related to EMT reveals similarities of mHsp70 expressing CECs with circulating tumor cells (CTCs) and suggest a mesenchymal-stemness origin. These findings may support the involvement of mHsp70 positive, stem cell-like cells in the development of endometriotic lesions. In summary, elevated levels of Hsp70 in the blood and CECs could serve as liquid biopsy markers for endometriosis and help to elucidate the underlying pathomechanism of the disease.

Preprint ARTICLE | doi:10.20944/preprints202407.0080.v1

Three-Dimensional Finite Element Analysis of Stress Distribution in Dental Implant Prosthesis and Surrounding Bone Using PEEK Abutments

Min-Ho Hong, Hyunsuk Choi

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Dental Implants; Finite element analysis; PEEK; Implant prosthesis

Online: 2 July 2024 (04:00:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0251.v1

Perceived Racial Discrimination, Psychological Distress, and Suicidal Behavior in Adolescence: Secondary Analysis of Cross-Sectional Data from a Statewide Youth Survey

Meredith Cahill, Robert Illback, Nicholas Peiper

Subject: Social Sciences, Psychiatry And Mental Health Keywords: racial discrimination; psychological distress; suicidal ideation; suicide attempts; adolescence

Online: 3 April 2024 (11:06:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0055.v1

Optimizing Lead Compounds: The Role of Artificial Intelligence in Drug Discovery

Sarfaraz K. Niazi, Zamara Mariam, Matthias Magoola

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: Lead optimization; drug discovery; artificial intelligence; machine learning; deep neural networks; cheminformatics; chemical modifications; drug development

Online: 1 April 2024 (13:35:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201610.0030.v1

Particulate Matter and Respiratory Symptoms among Adults Living in Windhoek, Namibia; a Cross Sectional Descriptive Study

Ndinomholo Hamatui, Caryl Beynon

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: respiratory symptoms; PM exposure; residential location; Namibia; Windhoek

Online: 10 October 2016 (09:59:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1750.v1

Acute Gastric Dilatation Syndrome in New World Non-Human Primates

Mônica Sousa, Raoane S. Siqueira, Harlan H. L. Nascimmento, Telma S. Lima, Raquel A. F. Silva, Nayadjala T.A. Santos, Thiago F.L. Nery, Karoline L. Lacerda, Lilian R.C. Eloy, Inácio José Clementino, Ricardo B. Lucena

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: congestion; infection; management; monkey; stomach; sudden death

Online: 23 September 2024 (12:51:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints201703.0235.v1

Social Determinants of Health and Epigenetics: A New Tool for Health Policy

Hitakshi Sehgal, William Toscano

Subject: Medicine And Pharmacology, Other Keywords: social determinants; epigenetics; exposome; public health policy; resilience; allostatic load; adaptation

Online: 31 March 2017 (11:35:57 CEST)

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Globally, humans are struggling with the double threat of communicable and non-communicable diseases, which are presenting new challenges to public health. Public health problems are generally studied and addressed at primary, secondary and tertiary levels. Most effective results are seen with primary interventions. Public health is becoming more aware of the importance of environment-gene interactions in the ontology of health and disease using epigenetics. Epigenetics is the study of altered gene expression without change in base pairs. Be it physical, social, behavioral, or economic factors; they all influence quality of life and health of individuals and populations. That environments are changing the human health phenotype and these changed phenotypes are heritable is of concern for the future of the human race. Knowing the causes of non-communicable human diseases using epigenetics will contribute to the development of new policies to encourage prevention using primary public health initiatives. Research and application of epigenetics shows great promise for improving population health. Continued advances in epigenetics will enhance how we understand and address the way environments are affecting the human health phenotype. For some time, health systems have been and continue to be tertiary in nature. Epigenetic changes can provide information necessary to better understand how social determinants of health can be used to build societies focused on equitable health for all people, rather than continuing to focus on treatment of diseases in the tertiary phase that leads to health disparities. Understanding mechanisms of social determinants of disease, will allow society to evolve in a health-oriented rather than a disease-oriented world. For this reason, we must enhance and apply epigenetics (physical, social, behavioral, economic) research to policy development. We will discuss how bringing social determinants together with biology can be used as new tools for public health policy.

Preprint ARTICLE | doi:10.20944/preprints202403.0989.v1

Prospective Observational Study of Oral Health in Hospitalized Diabetic Patients in the Internal Medicine Service of the Morales Meseguer Hospital

Jose Redondo-Ruiz, Juana Pinar-Sanchez, Miguel R. Pecci-Lloret, Francisco Javier Rodríguez-Lozano, Ricardo Elías Oñate-Sánchez

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: oral health; diabetes; periodontal disease; caries; periodontitis

Online: 18 March 2024 (07:22:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.0403.v1

Secure by Design Real-Time IoMT Architecture for e-Health Population Monitoring (RTPM)

Jims Marchang, Jade McDonald, Solan Keishing, Kavyan Zoughalian, Raymond Mawanda, Corentin Delhon-Bugard, Nicolas Bouillet

Subject: Computer Science And Mathematics, Security Systems Keywords: secure IoMT; secure IoT; patient health monitoring; secure monitoring; secure healthcare

Online: 10 June 2024 (12:27:46 CEST)

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The healthcare sector has undergone a profound transformation, owing to the influential role played by IoMT (Internet of Medical Things) technology. However, there are substantial concerns over these devices' security and privacy-preserving nature. Current literature on IoMT tends to focus on specific security features like data confidentiality or data integrity or data availability or access control and most solutions are simulated and not tested in a real-world live network. This paper proposes a smart secure by design solution that safeguards user’s data during health and wellbeing monitoring of patients locally (home, care-home, and hospital) and remotely. The proposed innovative solution is known as Secure by Design Real Time IoMT Architecture for e-Health Population Monitoring (RTPM) for smart hospitals and any healthcare monitoring management. In this system, keys can also be generated by the patient monitoring system independent to maintain high privacy standard and trust during the monitoring process and to enable the IoMT devices run independently even if the server is compromised and are made safe from external exploits to the client nodes. However, the session keys are controlled by the trusted IoMT server to lighten the IoMT devices overheads and the session keys are securely exchanged between the client system and the monitoring server. The proposed RTPM focuses on addressing the major security requirements for an IoMT system: confidentiality, integrity, availability, conducts authentication, protect from DoS attacks and prevent from non-repudiation attack of patient medical data and the devices in a real time, sensory data communication environment for live e-health monitoring. A secure communication is tested by capturing the live network traffic and the system’s performance analysis of RTPM using different security algorithms with different key sizes of RSA, AES, and SHA shows that resource constraint low powered system can also successfully integrate with high-end state-of-the-art secure parameters and features and have the potential to support real time secure interaction. A stress test is also conducted to ensure that the system can withstand huge key sizes and different data types including multi-media information.

Preprint REVIEW | doi:10.20944/preprints202408.0744.v1

Histone Deacetylase Inhibitors for Peripheral T-cell Lymphomas: From Biology to Real-World Therapy

Ruxandra Irimia, Pier Paolo Piccaluga

Subject: Medicine And Pharmacology, Hematology Keywords: Peripheral T-cell lymphoma; Histone deacetylase (HDAC); HDAC inhibitor (HDACi); targeted therapy; epigenetic; DNA mutation; TET2; DNMT3A

Online: 12 August 2024 (05:07:04 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202403.1397.v1

Changing the Nomenclature of Duct Dependent Lesions from Duct Dependent Pulmonary and Systemic to Duct Dependent Oxygenation and Perfusion

Antoine AbdelMassih, Acsah George, Dima Mohammad, Fazeela Ansari, Soumya Prachith

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Nomenclature of duct dependent lesions; Duct-dependent perfusion and oxygenation

Online: 23 March 2024 (09:35:15 CET)

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Preprint REVIEW | doi:10.20944/preprints202405.1996.v1

Coordination of Pathways in Metazoans: An Integrated Framework

Shiping Tang

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Pathway; Coordination; Network; Metazoans; Crosstalk; Communication

Online: 30 May 2024 (08:14:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.0148.v2

IoT-Integrated Vertical Fruit Display for Retail Store

Mohammed Arfat Raihan Chowdhury, Md Rakibul Hasan

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: food loss; fruit display; IoT; retail

Online: 4 December 2023 (11:59:06 CET)

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Preprint REVIEW | doi:10.20944/preprints202308.1920.v1

Integrated Management of Industrial Wastewater in Food Sector

Mona A. Abdel-Fatah

Subject: Engineering, Chemical Engineering Keywords: Integrated Management; Industrial Wastewater; Food Sector; sustainable; circular economy

Online: 29 August 2023 (03:55:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0128.v1

Graphene Oxide Thin Films for Nonlinear Integrated Photonics

David Moss

Subject: Physical Sciences, Optics And Photonics Keywords: graphene oxide, nonlinear optics, 2D materials

Online: 9 February 2022 (09:48:46 CET)

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Working Paper REVIEW

Characteristics of Future Models of Integrated Outpatient Care

Alan Leviton, Julia Oppenheimer, Madeline Chiujdea, Annalee Antonetty, Oluwafemi William Ojo, Stephanie Garcia, Sarah Weas, Eric Fleegler, Eugenia Chan, Tobias Loddenkemper

Subject: Medicine And Pharmacology, Other Keywords: consumer health informatics; E-health; mobile Apps; outpatient follow-up; patient portal; patient-reported outcomes

Online: 2 April 2019 (12:32:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0159.v2

Development of Piezoelectric Harvesters with Integrated Trimming Devices

Alberto Doria, Cristian Medè, Giulio Fanti, Daniele Desideri, Alvise Maschio, Federico Moro

Subject: Engineering, Mechanical Engineering Keywords: harvester; piezoelectric; dynamic vibration absorber; trimming

Online: 13 March 2018 (04:42:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints201705.0171.v1

A Novel Integrated High Precision Vacuum Microelectronic Accelerometer

Haitao Liu, Zhiyu Wen, Wengang Huang, Donglin Li, Li Chen, XiaoHan Yuan

Subject: Physical Sciences, Applied Physics Keywords: field emission; integrated; vacuum microelectronic; cathode tips array; interface ASIC

Online: 23 May 2017 (09:26:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1137.v1

Genomic Characterisation of Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Implicated in Bloodstream Infections, KwaZulu Natal, South Africa

Bakoena A. Hetsa, Jonathan Asante, Joshua Mbanga, Arshad Ismail, Akebe L. K Abia, Daniel G. Amoako, Sabiha Y. Essack

Subject: Biology And Life Sciences, Life Sciences Keywords: Staphylococcus aureus; bloodstream infections; whole-genome sequencing; antibiotic resistance; virulence

Online: 15 July 2024 (10:37:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0170.v1

In Their Own Words: The Health and Sexuality of Immigrant Women with Infibulation Living in Switzerland

Michela Villani, Judith, Louise Griffin, Patrick Bodenmann

Subject: Social Sciences, Sociology Keywords: migration; female genital mutilation; sexual health; reproductive health; communication

Online: 18 August 2016 (05:30:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1516.v1

Influence of Metabolic, Transporter, and Pathogenic Genes on Pharmacogenetics and DNA Methylation in Neurological Disorders

Olaia Martinez, Vinogran Naidoo, Iván Carrera, Juan C. Carril, Natalia Cacabelos, Ramón Cacabelos

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Epigenetics; DNA methylation; Pharmacogenetics; Neurological Disorders

Online: 21 July 2023 (13:20:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0012.v1

Vegetable Oil-Peroxidation Product ‘Hydroxynonenal’ Causes Hepatic Injury and Steatosis by Hsp70.1 and BHMT Disorders

Tetsumori Yamashima, Yurie Mori, Takuya Seike, Sharif Ahmed, Piyakarn Boontem, Shihui Li, Shinji Oikawa, Hatasu Kobayashi, Tatsuya Yamashita, Mitsuru Kikuchi, Shuichi Kaneko, Eishiro Mizukoshi

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: betaine-homocysteine S-methyltransferase; calpain-cathepsin hypothesis; carbonylation; cell death; lysosomal rupture; phosphatidylcholine

Online: 1 March 2023 (07:45:34 CET)

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Hsp70.1 has dual functions as chaperone protein and lysosomal stabilizer. Previously, we reported that calpain-mediated cleavage of carbonylated Hsp70.1 causes ischemic neuronal death by inducing lysosomal rupture. Recently, we found that the consecutive injections of vegetable oil-peroxidation product ‘hydroxynonenal’ induces hepatocyte death via the similar cascade. As Hsp70.1 is related also to fatty acid β-oxidation in the liver, its deficiency is known to cause accumulation of fat. Genetic deletion of betaine-homocysteine S-methyltransferase (BHMT) was reported to perturb choline metabolism, inducing decrease of phosphatidylcholine with the resultant hepatic steatosis. Here, focusing on disorders of Hsp70.1 and BHMT, we studied the mechanism of hepatocyte degeneration and steatosis, using monkeys after the consecutive injections of synthetic hydroxynonenal. As these monkeys showed a significant impairment of liver functions, the liver tissues without and with hydroxynonenal injections were compared by proteomics, immunoblotting, immunohisto-chemical and electron microscopic analyses. Western blotting showed upregulation of neither Hsp70.1 nor BHMT, but an increased cleavage of both proteins. Proteomics showed downregulation of Hsp70.1, while 2-fold increments of carbonylated BHMT. Hsp70.1 carbonylation was negligible, showing a marked contrast to ischemic neurons which were associated with ~10-fold increments. The control liver histologically showed lipid droplets in Ito cells, but lipid depositions within hepatocytes were very little. In contrast, after hydroxynonenal injections, widespread fatty degeneration and focal coagulation necrosis were observed with accumulation of numerous tiny lipid droplets within and around the degenerating/dying hepatocytes. Electron microscopy showed lysosomal membrane permeabilization/rupture, remarkable dissolution of mitochondria and rough ER membrane, and proliferation of abnormal peroxisomes. It is probable that disruptions of rough ER caused impaired synthesis of Hsp70.1 and BHMT proteins, while impairments of mitochondria and peroxisomes presumably contributed to the sustained generation of reactive oxygen species. Since both Hsp70.1 and BHMT are vulnerable to the long-standing oxidative stressor, hydroxynonenal-induced disorders facilitated degeneration and steatosis of hepatocytes, respectively.

Preprint REVIEW | doi:10.20944/preprints202407.2129.v1

Global Health Alert: Racing to Control Antimicrobial Resistant Candida auris and Waste Using UVC LED Technology

Jamie M Reedy, Theekshana Fernando, Silas O Awuor, Eric Omori Omwenga, Tatiana Koutchma, Richard M Mariita

Subject: Biology And Life Sciences, Life Sciences Keywords: Antimicrobial resistance; Candida auris; Global Spread; High Mortality Rates; Hospital Infections; Superbug; UVC Light; Hospital Waste Management

Online: 26 July 2024 (06:30:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201611.0131.v1

Transforming Food Systems at Local Levels: Using Participatory System Dynamics in an Interactive Manner to Refine Small-Scale Farmers’ Mental Models

Birgit Kopainsky, Gerid Hager, Hugo Herrera, Progress H. Nyanga

Subject: Biology And Life Sciences, Food Science And Technology Keywords: adaptation; mental model refinement; food systems; knowledge management participatory modeling; system dynamics; systems thinking

Online: 27 November 2016 (04:12:49 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1049.v1

True Benefits of Immune Checkpoint Inhibitors in the Treatment of Malignant Pleural Mesothelioma in Japan

Kozo Kuribayashi, Jun Hirano

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: malignant pleural mesothelioma; immune checkpoint inhibitor; orphan drug; good clinical practice; Pharmaceuticals and Medical Devices Agency

Online: 20 February 2024 (04:03:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0223.v1

The Relationship of Plasma Biomarkers of Alzheimer’s Disease and Neuropsychological Test Performance in Older Adults with Unimpaired Cognition: The Impact of Ethnicity

James Richard Hall, Melissa Petersen, Sid E. O’Bryant

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: neuropsychological tests; Alzheimer’ s disease; plasma biomarkers; ethnicity

Online: 2 April 2024 (15:15:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0700.v1

Prevalence and Correlates of Health Risk Behaviors among University Students from a State in the Southern Region of Brazil

Dartagnan Pinto Guedes, Keila Aparecida de Lima

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Lifestyles; surveys; university health; health promotion; public health; Brazil

Online: 10 April 2024 (10:47:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.1571.v1

Genome and Epigenome Disorders and Male Infertility: Feedback from 15 Years of Clinical and Research Experience

Benkhalifa Moncef, Debbie Montjean, Marion Beaumont, Abdelhafid Natiq, Noureddine Louanjli, André Hazout, Pierre Miron, Thomas Liehr, Cabry Rosalie, Ilham Ratbi

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Male infertility; genome and epigenome disorders

Online: 22 January 2024 (09:00:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0543.v1

The Influence of Probiotic Supplementation on Depressive Symptoms, Inflammation and Oxidative Stress Parameters and Faecal Microbiota in Patients with Depression Depending on Metabolic Syndrome Comorbidity – PRO-DEMET Randomised Study Protocol

Oliwia Gawlik-Kotelnicka, Anna Skowrońska, Aleksandra Margulska, Karolina H. Czarnecka-Chrebelska, Igor Łoniewski, Karolina Skonieczna-Żydecka, Dominik Strzelecki

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: depression; metabolic syndrome; probiotics; microbiota; inflammation; oxidative stress

Online: 24 February 2021 (11:20:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0214.v1

Curriculum Design and Sim2Real Transfer for Reinforcement Learning in Robotic Dual-Arm Assembly

Konstantin Wrede, Sebastian Zarnack, Robert Lange, Oliver Donath, Tommy Wohlfahrt, Ute Feldmann

Subject: Engineering, Control And Systems Engineering Keywords: Reinforcement learning; curriculum learning; simulation-to-reality; dual-arm robots; robotic assembly; peg-in-hole

Online: 3 September 2024 (11:50:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0773.v1

A New Definition of Dual Spline Curves for Curve Modeling and Geometry Defeaturing

Baotao Chi, Shengmin Bai, Qianjian Guo, Yaoming Zhang, Wei Yuan, Can Li

Subject: Computer Science And Mathematics, Geometry And Topology Keywords: Dual spline curves; Adaptive curve refinement; Curve modeling; Geometry defeaturing

Online: 12 July 2023 (05:50:49 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202211.0441.v1

A Dual Primary Malignancy – Ewing Sarcoma and Prostate Adenocarcinoma in A Single Patient

Arsen Shpigelman, David Maman, Benjamin Bernfeld

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Ewing sarcoma; Prostate adenocarcinoma; Cauda equina syndrome; Dual primary malignancy.

Online: 23 November 2022 (07:47:52 CET)

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Preprint REVIEW | doi:10.20944/preprints202207.0315.v1

Protocol of the Dual Burden of Animal and Human Zoonoses: A Systematic Review

Liz P. Noguera Z., Duriya Charypkhan, Simon Rüegg, Sonja Hartnack, Paul Torgerson

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: protocol; review; zoonosis; zoonotic diseases; infectious diseases; burden of diseases; DALY; zDALY; monetary burden; animal losses

Online: 21 July 2022 (08:12:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202111.0315.v1

Cellular and Molecular Mechanisms Implicated in the Dual Role of ROR2 in Cancer

Maria Victoria Castro, Pablo Lopez-Bergami

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: ROR2; cancer; oncogene; tumor-suppressor gene.

Online: 17 November 2021 (23:39:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0333.v1

Dual Aquaporin and Sigma1 Receptor (DAS) Modulators: New Tools for Counteracting Oxidative Stress

Giorgia Pellavio, Giacomo Rossino, Giulia Gastaldi, Daniela Rossi, Pasquale Linciano, Simona Collina, Umberto Laforenza

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: peroxiporins; oxidative stress; hydrogen peroxide; water channels; Sigma1 receptors; Sigma1 receptor modulators; neurodegenerative diseases

Online: 12 November 2020 (09:33:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0504.v1

A System for Assessing Dual Action Modulators of Glycine Transporters and Glycine Receptors

Diba Sheipouri, Casey Gallagher, Susan Shimmon, Tristan Rawling, Robert Vandenberg

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: glycine transporter; glycine receptor; analgesics; lipids

Online: 26 October 2020 (08:46:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0042.v1

Demographic Performance of Helicoverpa zea Populations on Dual and Triple-Gene Bt Cotton

Marcelo M. Rabelo, Silvana V. Paula-Moraes, Eliseu Jose G. Pereira, Blair D. Siegfried

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: fitness; life table; cotton bollworm; corn earworm; toxin; resistance management

Online: 5 July 2020 (04:42:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0100.v1

Thermodynamic Assessment and Multi-Objective Optimization of Performance of Irreversible Dual-Miller Cycle

Shahryar Abedinnezhad, Mohammad Hossein Ahmadi, Seyed Mohsen Pourkiaei, Fathollah Pourfayaz, Amir Mosavi, Michel Feidt, Shahab Shamshirband

Subject: Engineering, Control And Systems Engineering Keywords: Dual-Miller cycle; thermodynamic analysis; power; ecological coefficient of performance; thermal efficiency; entropy generation; multi-objective optimization

Online: 9 May 2019 (11:27:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0027.v1

(T,N) and Residual Fuzzy Co-Implication in Dual Heyting Algebra with Applications

Iqbal H. Jebril

Subject: Computer Science And Mathematics, Analysis Keywords: Fuzzy implications; (S,N) implication; residuum t-norm; (T,N) co-implication; residual co-implication

Online: 3 August 2016 (08:29:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0692.v1

Assessment of Health Centers Indoor Air Quality across Various Locations in Nigeria: A Comparative Analysis of Particle Count Data

Francis Olawale Abulude, Akinyinka Akinnusotu, Samuel Dare Oluwagbayide, Kikelomo Mabinuola Arifalo, Ademola Adamu, Amoke Monisola Kenni, Acha Sunday

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Indoor air quality; Health centers; Particle count analysis; Nigeria; Comparative analysis; Intervention strategies

Online: 12 August 2024 (03:47:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0667.v1

The Effect of The Audit Committee on The Voluntary Risk Disclosure In Jordanian Commercial banks: the moderating role of Family Ownership .

Abdullah Maani, Ola Buraik, Asmaa Al-amarneh, Mohmmed Almashaqbeh

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Keywords Audit Committee; Voluntary Risk Disclosure; Financial Companies; Family Ownership; Jordan

Online: 9 August 2024 (16:59:17 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202311.1180.v1

What’s Wrong with Enterprise Risk Management?

John Fraser, Rob Quail, Betty Simkins

Subject: Business, Economics And Management, Business And Management Keywords: Keywords: enterprise risk management; corporate governance; risk; risk management; COVID-19

Online: 21 November 2023 (10:18:17 CET)

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Preprint REVIEW | doi:10.20944/preprints201808.0293.v1

Palliative Care for Children with Central Nervous System Malignancies

Peter Baenziger, Karen Moody

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Keywords: palliative care, child, brain, neoplasm, neuropathic pain, pain, symptoms, hospice

Online: 16 August 2018 (15:14:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0016.v1

Motor Intentions Decoded from fMRI Signals

Sergio Ruiz, Sangkyun Lee, Josue Luiz Dalboni da Rocha, Ander Ramos, Emanuele Pasqualotto, Ernesto Soares, Eliana García, Eberhard Fetz, Niels Birbaumer, Ranganatha Sitaram

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: motor intention; fMRI; frontal lobe; parietal lobe; motor imaginary; neurorehabilitation; brain– computer interfaces

Online: 1 May 2024 (16:47:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1781.v1

Community Exercise Program Participation and Mental Well-Being in the U.S. Texas-Mexico Border Region

Belinda M Reininger, Alma G. Ochoa Del-Toro, Lisa A Mitchell-Bennett, Michael Machiorlatti, Candace A Robledo, Amanda C Davé, Rebecca N Lozoya

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: US-Mexico border health; community-wide campaign; physical exercise; mental health; public health; Latino community health; health behavior promotion

Online: 27 September 2023 (05:19:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0229.v1

Youth Exploring the Relationship between School Gardens, Food Literacy and Mental Well-Being Using Photovoice

Vanessa Lam, Kathy Romses, Kerry Renwick

Subject: Social Sciences, Education Keywords: mental health; food literacy; photovoice

Online: 22 April 2019 (10:29:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0422.v1

Antifungal Efficacy and Biofilm Inhibition of Candida albicans by Tea Tree Oil (Melaleuca alternifolia) in Vietnam: A Comprehensive Study

Dang Anh Tuan, Pham Vu Nhat Uyen, Nguyen Thi Tuong Van, Nguyen Van Khuon, Ly An Binh, Ngo Vo Thien Nhan, Jan Masak

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Candida albicans; tea tree oil (Melaleuca alternifolia); biofilm; antifungal; Minimum Inhibitory Concentration (MIC); Minimum Fungicidal Concentration (MFC)

Online: 9 September 2024 (04:32:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201609.0107.v1

Comprehensive Safety Evaluation of the Chemicals with Human and Environmental Relevance

Matteo Floris, Federica Albanese, Ricardo Medda, Emilio Benfenati

Subject: Environmental And Earth Sciences, Pollution Keywords: QSAR, Toxicology

Online: 27 September 2016 (11:34:40 CEST)

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Reducing the levels of toxic chemicals that cause adverse health and environmental impacts is a challenge for the international community. There is a need of a global strategy. Indeed, too often the problems associated to the exposure of chemical substances is recognized a posteriori, in the presence of consequences already observed. The prediction of the likely effects of chemical exposure on human health is based on classical tests with animals, which are time and money consuming, may deviate from an accurate prediction towards humans, and arises ethical concerns. Regulations are now considering the adoption of in silico (or computational) methods, which can be used for prioritizing substances according to the probability to be toxic for the biosphere. Several initiatives have prioritized chemicals, typically based according to some criteria, such as chemicals which may be endocrine disruptors, or persistent, bioaccumulative, or toxic (PBT). However, these initiatives focused on a certain range of adverse properties, and covered a certain number of substances only. We applied a set of largely validated and widely used predictive methods to large collections of chemicals: (i) to about 340,000 with a defined function, and (ii) to about 6 millions, which have been synthetized. The aim of this study is to quantify the putative impact of existing and future chemicals on towards human health, ecological and environment properties. The impact on the environment is the cause of major concern. This is the case of pesticides and hazardous, which is quite expected; however, also pharmacologically active candidate compounds of natural origin may have a high level of ecotoxicity. Pesticides and hazardous are also the categories of higher concern for humans, followed by pharmaceuticals. The pesticides and the hazardous are the categories of higher concern also on the environmental point of view. The results of our analysis could be the basis for the identification of new safety rules.

Preprint REVIEW | doi:10.20944/preprints202403.1182.v1

Present and Future Applications of Digital PCR in Infectious Diseases Diagnosis

Laura Sancha Domínguez, Ana Cotos Suárez, María Sánchez Ledesma, Juan Luis Muñoz Bellido

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: dPCR; digital PCR; infection; bacteria; virus; parasites

Online: 20 March 2024 (08:24:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0320.v1

National Agricultural Innovation System (NAIS): Diagnosis, Gaps and Mapping of Actors

Luis Fernando Gutiérrez Cano, Jhon Wilder Zartha Sossa, John Fredy Moreno Sarta, Juan Camilo Oviedo Lopera, Jorge Iván Quintero Saavedra, Lina María Suárez Guzmán, Diego Alejandro Agudelo Tapasco, Orlando Rodríguez García

Subject: Business, Economics And Management, Business And Management Keywords: Systems of Innovation,; National Agricultural Innovation System; gaps; Innovation and Development (R&D); training; , ICT; sustainability

Online: 6 March 2024 (04:29:00 CET)

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Preprint REVIEW | doi:10.20944/preprints202108.0513.v1

Liquid Biopsies in Epilepsy: Biomarkers for Etiology, Diagnosis, Prognosis, and Therapeutics

Jordan H. Whitlock, Tabea M. Soelter, Avery S. Williams, Andrew A. Hardigan, Brittany N. Lasseigne

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: liquid biopsy; epilepsy; circulating biomarkers; cfDNA; lncRNA; tRNA; miRNA; diagnosis; prognosis; therapeutics

Online: 26 August 2021 (16:40:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0106.v1

Seasonality of discrepancies between admission and discharge diagnosis for Medicare patients

Aashara Shrestha, Dimitrios Zikos, Leonidas Fegaras

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: Health Informatics; Clinical Decision Making; Seasonal Variations; Admission Diagnosis; Health Outcomes; Visualization

Online: 5 November 2018 (10:57:48 CET)

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Preprint REVIEW | doi:10.20944/preprints202408.0526.v1

One Health Ecological Approach in Sustainable Wireless En-ergy Transfer aboard Electric Vehicles for Smart Cities

Adel Razek

Subject: Environmental And Earth Sciences, Sustainable Science And Technology Keywords: One Health; Responsible Attitude; electric vehicles; wireless power transfer; smart cities; living tissues; biodiversity; clean energy

Online: 7 August 2024 (23:09:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1160.v1

Predicting Melanoma Immunotherapy Efficacy: Neural Network Models with Gene Expression and Clinical Data

Praveena Sunkara

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: ; artificial neural networks; immune checkpoint blockade; overall survival; progression-free survival ;

Online: 17 May 2024 (09:13:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1456.v1

Current Status and Challenges of Disaster Response and Rehabilitation Measures for Vulnerable Populations in Kagoshima Prefecture, Japan: A Cross-Sectional Study

Fumiyo Matsuda, Takumi Yamaguchi, Nobuhiko Yanagida, Yuko Matsunari

Subject: Public Health And Healthcare, Health Policy And Services Keywords: Disaster Rehabilitation; Vulnerable Populations; Disaster Preparedness; Local Govern

Online: 20 August 2024 (14:20:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0591.v1

Sarcopenia and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Narrative Review

Ludovico Abenavoli, Michael Statsenko, Giuseppe Guido Maria Scarlata, Domenico Morano, Roman Myazin, Dmitriy Emelyanov

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: sarcopenia; metabolic dysfunction-associated steatotic liver disease; diagnostic; treatment

Online: 8 August 2024 (17:12:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2410.v1

Occupational Health Problems among Cambodian Dentists: A Cross-Section Study

Rodrigo Mariño, Rithvitou Horn, Moniroth Seat, Konitha Hong, Sokpheakta Hen

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Oral health professions; Occupational health; Musculo-skeletal disorder; Cambodia

Online: 30 July 2024 (11:04:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0778.v1

Enhancing Knowledge-Aware Recommendation with Dual-Graph Contrastive Learning

Jinchao Huang, Zhipu Xie, Han Zhang, Bin Yang, Chong Di, Runhe Huang

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Dual-graph Learning; Contrastive Learning; Knowledge Graph; User-Item Graph; Recommendation System

Online: 10 July 2024 (10:54:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1134.v1

A Dual Hilbert-Space Formalism for Consciousness; Memory Experiments

Robert Englman, Asher Yahalom

Subject: Physical Sciences, Quantum Science And Technology Keywords: Quantum Mechanics, Consciousness

Online: 17 May 2024 (12:39:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202402.1650.v1

Heteronuclear Dual Metal Atom Electrocatalysts for Water-Splitting Reactions

Lu Lu, Xingcai Wu

Subject: Chemistry And Materials Science, Electrochemistry Keywords: Heteronuclear dual metal atoms; electrocatalysts; water-splitting; electrocatalytic mechanism

Online: 29 February 2024 (08:13:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0316.v1

The Dual Quaternion Matrix Equation AXB=C with Applications

Yan Chen, Qing-Wen Wang, Lv-Ming Xie

Subject: Physical Sciences, Mathematical Physics Keywords: Dual Quaternion; Moore-Penrose inverse; ϕ-Hermitian solution; matrix equations

Online: 6 February 2024 (09:14:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0586.v1

Spatio-Temporal Dual Kriging with Adaptive Coefficient Drift Function

Chalida Kongsanun, Nawinda Chutsagulprom, Sompop Moonchai

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: geostatistics; spatio-temporal interpolation; spatio-temporal dual kriging; spatio-temporal kriging with external drift; spatio-temporal regression kriging; drift function; adaptive coefficient

Online: 8 January 2024 (13:44:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0615.v1

Secure Cloud Computing By A dual-Layer Encryption Mechanism

Sanaa Ali Jabber, Soukaena Hashem, Shtha Jafer

Subject: Computer Science And Mathematics, Security Systems Keywords: cloud; storage; secure; SOA; AES; RSA; LSTM

Online: 8 December 2023 (13:15:30 CET)

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Preprint REVIEW | doi:10.20944/preprints202307.0985.v1

The Dual Role of Necroptosis in Pancreatic Ductal Adenocarcinoma

Valentina Giansante, Gianmarco Stati, Silvia Sancilio, Emanuela Guerra, Saverio Alberti, Roberta Di Pietro

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: pancreatic cancer; necroptosis; tumor microenvironment; cell death

Online: 14 July 2023 (09:07:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0074.v1

Isochoric Specific Heat in the Dual Model of Liquids

Fabio Peluso

Subject: Physical Sciences, Condensed Matter Physics Keywords: Liquid model; Phonons in liquids; Instantaneous Normal Modes; Mesoscopic model of liquids; Phonon – particle interaction; Specific heat

Online: 3 November 2021 (09:14:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202005.0013.v1

Vertical Organic Permeable Dual-Base Transistors for Logic Circuits

Erjuan Guo, Zhongbin Wu, Ghader Darbandy, Shen Xing, Shu-Jen Wang, Alexander Tahn, Michael Göbel, Alexander Kloes, Karl Leo, Hans Kleemann

Subject: Physical Sciences, Applied Physics Keywords: organic permeable dual-base transistors; vertical channel; logic circuits; threshold voltage; TCAD simulation

Online: 2 May 2020 (13:29:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints201810.0616.v1

Dual-Family Peptidylprolyl Isomerases (Immunophilins) of Select Monocellular Organisms

Sailen Barik

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: peptidylprolyl isomerase; chaperone; immunophilin; extremophile; intrinsic disorder

Online: 26 October 2018 (05:20:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0604.v1

Sentiment Analysis of Social Media Data on Ebola Outbreak Using Deep Learning Classifiers

Alex Mirugwe, Clare Ashaba, Alice Namale, Evelyn Akello, Edward Bichetero, Edgar Kansiime, Juwa Nyirenda

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Ebola; Deep learning; Sentiment Analysis; Natural Language Processing

Online: 9 April 2024 (07:20:36 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202403.0752.v1

Ovarian Fibrothecoma in a Mare-Case Report

Raimonda Tamulionytė-Skėrė, Nomeda Juodžiukynienė, Paulina Rimkutė, Renata Gruodytė, Iveta Duliebaitė, Akvilė Savickytė

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: thecoma; ovarian tumor; neoplasia; histopathology

Online: 13 March 2024 (07:24:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.1007.v1

The Utility of C-Reactive Protein, Procalcitonin, and Leukocyte Values in Predicting the Prognosis of Patients with Pneumosepsis and Septic Shock

Melek Doganci, Guler Eraslan Doganay, Hilal Sazak, Ali Alagöz, Mustafa Ozgur Cirik, Derya Hoşgün, Emine Banu Cakiroglu, Murat Yildiz, Maside Ari, Tarkan Ozdemir, Derya Kizilgoz

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: C-reactive protein,; leukocyte; pneumosepsis; procalcitonin; septic shock

Online: 14 August 2024 (09:40:53 CEST)

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Background: The predictive value of changes in C-reactive protein (CRP), procalcitonin and leukocyte levels, which are commonly used in the diagnosis of infection in sepsis and septic shock, remains a topic of debate. This study aims to evaluate the effectiveness of changes in CRP, procalcitonin, and leukocyte counts on the prognosis of patients admitted to the intensive care unit (ICU) with a diagnosis of pneumosepsis and pneumonia-related septic shock, and to investigate whether any of these markers have a superior predictive value over the others in forecasting prognosis. Methods: The study analyzed the demographic data, Charlson Comorbidity Index score (CCIS), CURB-65 score (confusion, uremia, respiratory rate, BP, age ≥ 65 years), and Acute Physiology and Chronic Health Evaluation II (APACHE-II) scores of 230 patients admitted to the ICU with a diagnosis of pneumosepsis and pneumonia-related septic shock between April 1, 2022, and December 31, 2023. The levels of CRP, procalcitonin, and leukocytes were also recorded and analyzed to assess their impact on 1-month and 3-month mortality outcomes. Results: According to multivariate logistic regression analysis, low BMI, male gender, high CCIS, CURB-65, and APACHE-II scores were found to be significantly associated with both 1-month and 3-month mortality (p<0.05). An elevated SOFA score was associated with 1-month mortality, while advanced age was related to 3-month mortality (p<0.05). Although there was no significant relationship between the first-day levels of leukocytes, CRP, and PCT and mortality, their levels on the third day were observed to be at their highest in both 1-month and 3-month mortality cases (p<0.05). Additionally, a concurrent increase in any two or all three of CRP, PCT, and leukocyte values was found to be higher in patients with 3-month mortality compared to those who survived (p=0.004). Discussion: Although PCT, CRP, and leukocyte values measured at the time of admission were not significantly associated with 1-month mortality in patients with pneumosepsis or pneumonia-related septic shock, the persistent elevation and concurrent increase of these values, along with male gender, advanced age, low BMI, and high CCIS, CURB-65, and APACHE-II scores, were found to be significantly associated with 3-month mortality.

Preprint ARTICLE | doi:10.20944/preprints201809.0518.v1

Study on the Preferred Application-Oriented Index for Mental Fatigue Detection

Tianhong Duan, Nong Zhang, Kaiway Li, Xuelin Hou, Jun Pei

Subject: Social Sciences, Psychology Keywords: mental fatigue; one-way ANOVA; digital decoding testing; relative fatigue index (RFI); Sensitivity ordering

Online: 26 September 2018 (14:42:02 CEST)

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Most of the research of mental fatigue evaluation mainly concentrated on some indexes that require sophisticate and large instruments which make the detection of mental fatigue cumbersome, time-consuming, and difficult to apply on a large scale. A quick and sensitive mental fatigue detection index is necessary so that mental workers can be alerted in time and take corresponding countermeasures. But to date, no studies have compared the sensitivity of common objective evaluation indexes. To solve these problems this study recruited 56 human subjects. These subjects were evaluated using six fatigue indexes: the Stanford sleepiness scale, digital span, digital decoding, short-term memory, critical flicker fusion frequency (CFF), and speed perception deviation. The results of fatigue tests before and after mental fatigue were compared, and a one-way analysis of variance (ANOVA) was performed on the speed perception deviation. The result indicated the significance of this index. Considering individual differences, the relative fatigue index (RFI) was proposed to compare the sensitivity of the indexes. The results showed that when the self-rated fatigue grade changed from non-fatigue to mild fatigue, the ranges of RFI values for digital span, digital decoding, short-term memory and CFF were 0.175–0.258, 0.194–0.316, 0.068–0.139, and 0.055–0.075, respectively. Correspondingly, when the self-rated fatigue grade changed from non-fatigue to severe fatigue, the ranges of RFI values for the above indexes were 0.175–0.258, 0.194–0.316, 0.068–0.139, and 0.055–0.075, respectively. These results suggest that the sensitivity of the digital decoding, digital span, short-term memory, and CFF decreased sequentially when the self-evaluated fatigue grade changed from no fatigue to mild or severe fatigue. The RFI individuality of the speed perception deviation is highly variable and is not suitable as an evaluation index. In mental fatigue testing, digital decoding testing can provide faster, more convenient, and more accurate results.

Preprint ARTICLE | doi:10.20944/preprints202408.1663.v2

Periprosthetic Knee Infection: From Diagnosis to Surgery

Antonio Spinarelli, Biagio Moretti, Maria Catalano, Marco Smaldino, Giuseppe Solarino

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: TKA; Infection; PJI

Online: 27 August 2024 (17:01:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0591.v1

A CNN Classification Model For Diagnosis Covid19

Ahmed Abdullah Farid, hatem khater, gamal selim

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Bacterial -Viral Pneumonia; COVID-19; X-ray Image; Deep Learning; Convolution Neural Network

Online: 24 July 2020 (14:02:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0069.v1

B-Cell Maturation Antigen (BCMA) as a Biomarker and Potential Treatment Target in Systemic Lupus Erythematosus

Jonas Martin, Qingyu Cheng, Sarah A. Laurent, Franziska Thaler, Anne Elisabeth Beenken, Edgar Meinl, Gerhard Krönke, Falk Hiepe, Tobias Alexander

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: SLE; BAFF; BCMA; TACI; lupus; B cells; plasma cells

Online: 2 September 2024 (10:51:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2342.v1

Paul A Peters, Morgan Klym, Michel Lopez Barrios, Tomoko McGaughey

Subject: Social Sciences, Demography Keywords: multiple causes of death; comorbidity; mortality; mortality determinants; COVID-19; chronic diseases; population health; demography

Online: 30 September 2024 (08:37:42 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints201612.0049.v1

On Equivalence of Quantum Liouville Equation and Metric Compatibility Condition, a Ricci Flow Approach

Manouchehr Amiri

Subject: Physical Sciences, Quantum Science And Technology Keywords: Quantum Liouville equation; metric compatibility condition; Joint probability; Binary Data Matrix; Ricci flow

Online: 9 December 2016 (02:13:06 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.1482.v1

Treatment of Aggressive Behavior and Agitation in a 11-Year-Old Boy With Co-occurring Autism and ADHD: A Case Report and Literature Review on the Use of Intravenous Valproate in Emergency Psychiatry

Alessandra Carta, Vanna Cavassa, Mariangela V. Puci, Roberto Averna, Giovanni Sotgiu, Giovanni Valeri, Stefano Vicari, Stefano Sotgiu

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Autism; ADHD; agitation; intravenous valproate.

Online: 26 March 2024 (08:20:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.1855.v1

Antimicrobial Susceptibility of Uropathogenic Escherichia coli with Analysis of Impact of Socio-Economic Factors in Low, Medium and High-Income Countries

Meher Rizvi, Maria Khan, Amina AL Jardani, Ujjala Ghoshal, Zaaima AL Jabri, Mohammad Ahanjan, Azza AL Mamari, Nawal AL Shizawi, Hiba Sami, Abdullah Balkhair, Adila Shaukat, Alwarith Nasser Salem Alkharusi, Abdulrahman Almahrouqi, Afreenish Hassan, Ajay Kumar, Amal Malehi, Amina Gul, Ashima Singh, Asma Said Hamed AL Shidhani, Areena Hoda Siddiqui, Aruna Poojary, Azza AL Rashdi, Bradley Langford, Dmytro Stepanskyi, Abbas Dolatabadi, Aisha Al Mufraji AL Mufraji, Elham Said Ahmed AL Risi, Garima Kapoor, Isabella Princess, Hatim Ali Eltahir, Hilal Al Sidairi, Kaitlyn Dougherty, Katia Iskandar, Ken Masters, Ibrahim Khalaf Hamdan AL Busaidi, Laila AL Yazidi, Mahfuza Nasrin, Mahmood Salim AL Subhi, Mallika Sengupta Mallika Sengupta, Manisha Khandait, Nada Khalfan AL Tamtami, Nada Khafan Alsiyabi, Nawal AL Kindi, Nazla Musthafa Luthfee, Neha Shreshtha, Nihal Mohamed Amur AL Riyami, Noora Hilal Ali AL Busaidi, Nupur Goel, Oksana Ishchenko, Omnia Mohamed Elnabawy Ahmed Taher, Pragnya Paramita Jena, Rajni Ekadashi, Razan Zadjali, Reba Kanungo, Sara Abolghasemi, Salima Al-maqbali, Sanjay Jaju, Sayantan Banerjee, Shadma Yaqoob, Shahnaz Sali, Shafqat Husnain Khan, Shalini Malhotra, Stephen Hughes, Sundas Shaukat, Syed Mohammed Atif, Vrushali Vishwas Patwardhan, Victorien Dougnon, Wahid Khan, Walid Wali, Zakariya AL Muharrmi, Zeeshana Basit, Jasashree Choudhury, Rachita Pravalina, Sanjeev Singh, Sarman Singh, Neelam Taneja, Raman Sardana, Pawan Kapoor, Rajeev Soman, Rashid Al Abri

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: community acquired UTI; Escherichia coli; antimicrobial susceptibility; Indian subcontinent; MENA; GDP; temperature

Online: 24 September 2024 (12:32:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0786.v1

Insights into Perimenopause: A Survey of Perceptions, Opinions on Treatment, and Potential Approaches

Andrea K. Wegrzynowicz, Amanda C. Walls, Myra Godfrey, Amy Beckley

Subject: Public Health And Healthcare, Primary Health Care Keywords: perimenopause; menopause; women’ s health; Hormone Replacement Therapy (HRT); symptom management; healthcare communication; survey analysis; women’ s wellness; stigma; at‐home solutions

Online: 10 September 2024 (10:50:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.1859.v1

Iron Oxide Nanoparticles as Photothermal Agents: Optimal Parameters for Photoconversion Efficiency and Ability for Synergistic Cancer Treatment

Tsenka Grancharova, Plamen Zagorchev, Bissera Pilicheva

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: iron oxide; photothermia; theranostic; synergistic; cancer; nanomedicine; nanoparticles

Online: 28 May 2024 (12:05:23 CEST)

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