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Preprint ARTICLE | doi:10.20944/preprints202406.1086.v1

Evaluation of Open-Source Ciliary Analysis Software in Primary Ciliary Dyskinesia: A Comparative Assessment

Zachary J. Demetriou, José Muñiz-Hernández, Gabriel Rosario-Ortiz, Frances M. Quiñones, Gabriel Gonzalez-Diaz, Marcos J. Ramos-Benitez, Ricardo A. Mosquera, Wilfredo De Jesús-Rojas

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: primary ciliary dyskinesia; ciliary beat frequency; high-speed video microscopy analysis; Cilialyzer; CiliarMove

Online: 17 June 2024 (08:06:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1543.v1

The Ripple Effect: Quality of Life and Mental Health of Parents of children with ADHD in Saudi Arabia a Cross-Sectional Study

Shuliweeh Alenezi, Samah H Alkhawashki, Muneera AlKhorayef, Sarah Alarifi, Shahad Alsahil, Renad AlHaqbani, Nouf Alhussaini

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: ADHD; parents; mental health; parenting challenges

Online: 26 March 2024 (11:52:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1487.v1

Examining The Association of Violence at Multiple Ecological Levels and Child Mental Health Outcomes in Iraq: Mapping Where Are the Most Vulnerable.

Ruaa Al Juboori

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: child abuse; violence; domestic violence; corporal punishment; depression; anxiety; spatial; Iraq

Online: 20 December 2023 (09:44:51 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.1505.v1

Our Mental Health is Determined by an Intrinsic Interplay Between the Central Nervous System, Enteric Nerves, and Signals Generated by Gut Microbiota

Leon M. T. Dicks

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Gut microbiota; enteric nervous system; mental health

Online: 23 November 2023 (10:33:09 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.0584.v1

Nurturing the Positive Mental Health of Autistic Children, Adolescents and Adults alongside That of Their Familycare-Givers: A Scoping Review of Reviews

Roy McConkey

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Autism; Autistic; Mental health; emotional wellbeing; family caregivers; Low and middle in-come countries; review; international

Online: 9 November 2023 (07:29:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1470.v1

Difference of Gender on Adverse Mental Health and Associated Factors in Waste Workers in Brasília, Brazil in the Context of the Pandemic

Jefferson Santos, Tara Zolnikov, Ana Carolina Martins, Dayani Galato, Giullia Couto, Josenaide Santos, Max Oliveira, Vanessa Cruvinel

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Covid-19; Waste pickers; Street sweepers; Occupational Health; Mental Health

Online: 21 June 2023 (03:51:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1876.v1

Assessment of Particulate Organic Carbon in the Mediterranean Sea Based on Dual-Optimization Random Forest

Chao Li, Huisheng Wu, Chaojun Yang, Long Cui, Ziyue Ma, Lejie Wang

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: particle organic carbon; Mediterranean; machine learning; tuneRanger R package; geographic detector

Online: 28 May 2024 (14:28:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0212.v1

Dietary Patterns Correlate with Transition Readiness of Adolescents with Autism: A Pilot Study

Lilian de Jonge, Blessing Seidu

Subject: Public Health And Healthcare, Other Keywords: Adolescents with autism; Comorbidities in autism; Dietary quality of adolescents with autism; Transition to adulthood for people with autism; Cross-sectional study

Online: 4 September 2024 (04:34:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.2112.v1

A Novel Sampling Method for Collecting the Polyp Stage of the Invasive Freshwater Hydrozoan Craspedacusta sowerbii in Aquatic Habitats

Jonathan A. Zhu, Nadine C. Folino-Rorem

Subject: Biology And Life Sciences, Aquatic Science Keywords: Invasive hydrozoan; sampling; polyp; frustule

Online: 31 May 2024 (10:48:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0169.v1

A Longitudinal Approach to Biological Psychiatric Research: The PsyCourse Study

Monika Budde, Heike Anderson-Schmidt, Katrin Gade, Daniela Reich-Erkelenz, Kristina Adorjan, Janos L. Kalman, Fanny Senner, Sergi Papiol, Till F. M. Andlauer, Ashley L. Comes, Eva C. Schulte, Farah Klöhn-Saghatolislam , Anna Gryaznova, Maria Hake, Kim Bartholdi, Laura Flatau, Markus Reitt, Silke Quast, Sophia Stegmaier, Milena Meyers, Barbara Emons, Ida Sybille Haußleiter, Georg Juckel, Vanessa Nieratschker, Udo Dannlowski, Max Schmauß, Jörg Zimmermann, Jens Reimer, Sybille Schulz, Jens Wiltfang, Eva Reininghaus, Ion-George Anghelescu, Volker Arolt, Bernhard T. Baune, Carsten Konrad, Andreas Thiel, Andreas J. Fallgatter, Christian Figge, Martin von Hagen, Manfred Koller, Fabian U. Lang, Moritz E. Wigand, Thomas Becker, Markus Jäger, Detlef E. Dietrich, Sebastian Stierl, Harald Scherk, Carsten Spitzer, Here Folkerts, Stephanie H. Witt, Franziska Degenhardt, Andreas J. Forstner, Marcella Rietschel, Markus M. Nöthen, Peter Falkai, Thomas G. Schulze, Urs Heilbronner

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Schizophrenia; bipolar; psychosis; depression; polygenic risk score; diagnosis; RDoC

Online: 27 October 2017 (11:58:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0243.v1

Useful Predictor for Exacerbation of Esophagogastric Varices after Hepatitis C Virus Eradication by Direct-Acting Antivirals

Yuko Nagaoki, Kenji Yamaoka, Yasutoshi Fujii, Shinsuke Uchikawa, Hatsue Fujino, Atsushi Ono, Eisuke Murakami, Tomokazu Kawaoka, Daiki Miki, Hiroshi Aikata, C. Nelson Hayes, Masataka Tsuge, Shiro Oka

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Direct-acting antiviral; sustained virological response; esophagogastric varices; liver stiffness measurement; total bile acid; left gastric vein

Online: 5 June 2024 (10:53:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0652.v1

Dual-Frequency Terahertz Amplitude Modulator Based on the Coupling Effect of Cross-Shaped Structure and U-Shaped Metal Patches

Zhen Zhang, Linji Yang, Huan Zhou, Kuan Ye, Sen Qiu, Xin Chen, Yong Ma, Renpu Li

Subject: Physical Sciences, Optics And Photonics Keywords: terahertz waves; metamaterial; amplitude modulator

Online: 11 June 2024 (10:34:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0508.v1

MMD-MSD: A Multimodal Multisensory Dataset in Support of Musculoskeletal Disorders Research and Technology Development

Valentina Markova, Todor Ganchev, Silvia Filkova, Miroslav Markov

Subject: Computer Science And Mathematics, Other Keywords: multimodal dataset; musculoskeletal disorders prevention; computer-oriented working environment; performance evaluation; Stroop test; PPG; EDA; skin temperature; pictures; video; three-axis accelerometer

Online: 8 April 2024 (08:52:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0006.v1

The Impact on Children's Mental Health of School Closures to Prevent the Spread of the Novel Coronavirus (COVID-19)

Yuma Ishimoto, Takahiro Yamane, Yuki Matsumoto, Katsutoshi Kobayashi

Subject: Social Sciences, Psychology Keywords: Covid-19; School Closure; Elementary School; Emotional Symptoms; Japan

Online: 2 June 2020 (14:58:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0335.v1

Integrated Impact Assessment of Active Travel: Expanding the Scope of the Health Economic Assessment Tool (HEAT) for Walking and Cycling

Thomas Götschi, Sonja Kahlmeier, Alberto Castro Fernandez, Christian Brand, Nick Cavill, Paul Kelly, Christoph Lieb, David Rojas Rueda, James Woodcock, Francesca Racioppi

Subject: Public Health And Healthcare, Health Policy And Services Keywords: active transportation; health impact assessment; physical activity; air pollution; traffic safety; carbon emissions; monetization; online tool

Online: 15 September 2020 (08:40:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1988.v1

Dual Antibiotic Approach: Synthesis and Antibacterial Activity of Antibiotic‐Antimicrobial Peptide Conjugates

Maria Cristina Bellucci, Carola Romani, Monica Sani, Alessandro Volonterio

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: antimicrobial peptides; antibiotics; ‐lactams; vancomycin; aminoglycosides; chemical conjugation; combination therapy

Online: 25 July 2024 (08:01:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0885.v1

TAS2R38 Genotype Does Not Affect SARS-CoV-2 Infection in Primary Ciliary Dyskinesia

Gioia Piatti, Giorgia Girotto, Maria Pina Concas, Leonardo Braga, Umberto Ambrosetti, Mirko Aldè

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: bitter taste receptors; TAS2R38; Primary Ciliary Dyskinesia; COVID-19; SARS-CoV-2

Online: 13 June 2024 (05:37:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0669.v1

Adverse Childhood Experiences Combined with Emotional and Physical Abuse by the Partner Predict Antenatal Depression.

Yoshiko Abe, Wandee Sirichokchatchawan, Ussanee Sangkomkamhang, Sirina Satthapisit, Michael Maes

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Antenatal depression; Adverse childhood experiences; intimate partner violence; social support

Online: 26 March 2021 (14:18:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.0941.v1

A BIM Package with NEC4 Contract Option to Mitigate Construction Disputes in the Kingdom of Saudi Arabia

Reda Abdelshafy Abougamil, David Thorpe, Amirhossein Heravi

Subject: Engineering, Civil Engineering Keywords: building information modelling; Kingdom of Saudi Arabia; disputes; construction; contracts; NEC4, procurement.

Online: 14 May 2024 (09:12:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201609.0024.v1

Identification of One BOCR Mutation and Five NF1 Mutations in Male Patients with Neurofibromatosis Type 1 and Congenital Pseudarthrosis of the Tibia

Zhifan Zhou, Yong Zeng, Xinchun Wu, Fei Li, Xiaoyan Liu, Lu Zhou, Lihua Hou, Silong Sun, Lu Shen, Zhangyuan Lin

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: neurofibromatosis type 1; congenital pseudarthrosis of the tibia; whole-exome sequencing; targeted sequencing; BCOR

Online: 7 September 2016 (11:19:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2048.v1

Two-Dimensional Directions Determination for GNSS Spoofing Source Based on MEMS-Based Dual-GNSS/INS Integration

Chengzhong Zhang, Dingjie Wang, Jie Wu

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: GNSS spoofing interference; MIMU; integrated navigation; spoofing signal source; integer ambiguity; common-clock receiver

Online: 26 September 2024 (09:53:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0239.v1

An Immunoinformatics Approach for Identifying and Designing Conserved Multi-Epitope Vaccines for Coronaviruses

Yu Chuan Ong, Bimo Ario Tejo, Wei Boon Yap

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; coronavirus; universal vaccine; peptide; cell-mediated immunity

Online: 3 September 2024 (18:08:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2254.v1

Terahertz Dielectric Metasurface for Reconfigurable Multifunctional Holographic Imaging with Dual-Mode Controlled by Graphene

Hui-Fen Huang, Jian-Yuan Wang

Subject: Engineering, Electrical And Electronic Engineering Keywords: terahertz; metasurface; holographic; graphene; reconfigurability

Online: 29 July 2024 (08:25:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1470.v1

Unveiling the Environmental-Economic Nexus: Cointegration and Causality Analysis of Air Pollution and Growth in Oman

Sufian Eltayeb Abdel-Gadir, Mwahib Ahmed Mohammed

Subject: Environmental And Earth Sciences, Pollution Keywords: Air Pollution; Cointegration; Oman

Online: 24 October 2023 (07:55:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.2186.v1

Laboratory Tests Might Mitigate Misdiagnosis of Child Abuse Established on Clinical Grounds

Sergio Verd, Elisa Lizarbe, Elena Sol, Alicia-Esther Tur

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Child abuse; Child growth; Child custody; Oxidative stress; Aspartate aminotransferase; Fatty liver; Insulin resistance

Online: 31 January 2024 (12:54:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.1355.v1

Anthropometric and Biochemical Analysis and Dietary Habits in Elite Spanish Female Football Players

Agustin Mora-Fernandez, Julia Peinado Rojas, Nuria Gimenez-Blasi, Javier Conde-Pipo, Jose Antonio Latorre, Miguel Mariscal-Arcas

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: body composition; female athletes; football; biochemical analysis; nutrition; diet

Online: 21 May 2024 (09:11:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0829.v1

Exploring Phytochemical Therapies for Long COVID: A Computational Docking Study of Phytochemicals with GPCR Targets

Pavithren Aaron, Suresh Kumar

Subject: Biology And Life Sciences, Virology Keywords: long covid; GPCR; receptor; drugs; chemokine receptors; serotonin receptors; adrenergic receptors; and histamine receptors docking; phytochemical

Online: 12 August 2024 (14:13:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1243.v1

An Integrated Testbed for Power System Cyber-Physical Operations Training

Manohar Chamana, Rabindra Bhatta, Konrad Schmitt, Rajendra Shrestha, And Stephen Bayne

Subject: Engineering, Electrical And Electronic Engineering Keywords: Cyber-Security; Cyber-Physical Systems; Education; Power Systems; Real-Time testbed Smart Grids

Online: 18 July 2023 (14:22:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0684.v1

Inflammatory Prostatitis plus IBS-D Subtype and Correlation with the Immunomodulating Agent Imbalance in Seminal Plasma: Novel Combined Treatment

Roberto Castiglione, Gaetano Bertino, Beatrice Ornella Vicari, Agostino Rizzotto, Giuseppe Sidoti, Placido D'Agati, Michele Salemi, Giulia Malaguarnera, Enzo Vicari

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: irritable bowel syndrome; inflammatory prostatitis; IBS-severity scoring system; rifaximin; probiotic VSL#3; interleukins; seminal plasma

Online: 9 August 2024 (17:00:49 CEST)

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We recently demonstrated the effectiveness of long-term treatment with rifaximin and the probiotic VSL#3 at improving urogenital and gastrointestinal symptoms in patients with both chronic inflammatory prostatitis (IIIa prostatitis) and diarrhea-predominant irritable bowel syndrome (IBS-D), relative to patients with IBS-D alone. Because low-grade inflammation of the intestine and prostate may be one of the reasons for co-developing both IIIa prostatitis and IBS-D, we designed the present study to once again evaluate the efficacy of combined rifaximin and VSL#3 treatment in patients affected by IIIa prostatitis plus IBS-D, but we also measured seminal plasma pro-inflammatory (IL-6) and anti-inflammatory (IL-10) cytokines before and after treatment. We consecutively enrolled 124 patients with IIIa prostatitis and IBS-D (diagnosed using the Rome III criteria). Patients were randomized into two groups: group A (n=64) was treated with rifaximin (seven days per month for three months) followed by VSL#3, and group B (n=60) was treated with a placebo. At the beginning of the study and after three months of treatment, all patients completed NIH-CPSI and IBS-SSS questionnaires to score the severity of their urogenital and gastrointestinal symptoms, and we measured seminal plasma levels of IL-6 and IL-10 using ELISA. We defined patients who improved following the treatment as those with a ≥6-point reduction in their NIH-CPSI score or ≥50-point reduction in their IBS-SSS score. By the end of the intervention, 68.7% and 62.5% of patients from group A reported improved NIH-CPSI and IBS-SSS scores, respectively, compared to only 3.3% and 5% of the placebo group. Group A patients also had significantly lower mean seminal plasma levels of IL-6 (11.3 vs 32.4 pg/mL) and significantly higher mean levels of IL-10 (7.9 vs 4.4 pg/mL) relative to baseline, whereas levels of IL-6 and Il-10 did not change in the placebo group. The co-occurrence of two clinical phenotypes (IBS-D plus IIIa prostatitis) result in increased intestinal inflammation and altered immune activation, both of which can be balanced by treatment with rifaximin and VSL#3.

Preprint ARTICLE | doi:10.20944/preprints202404.1159.v1

Study on Fault Diagnosis Technology for Efficient Swarm Control Operation of Unmanned Surface Vehicles

Sangki Jeong, Min Kyu Kim, Heayong Pak, Yoon Chil Kim, Dae-Hyeong Ji

Subject: Engineering, Control And Systems Engineering Keywords: Unmanned Surface Vehicles (USVs); Recurrent Neural Network (RNN); Long Short-Term Memory models (LSTM); Artificial Neural Networks (ANN-PID)

Online: 17 April 2024 (13:32:19 CEST)

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This study aimed to learn disturbance information to effectively control multiple small unmanned surface vehicles (USVs) for marine research purposes at sea. The learned disturbance information was used to investigate the control of multiple USV swarms based on the leading–following formation technique. Numerous studies have already been conducted on swarm control using drones in the air; however, there has been a paucity of studies on swarm control in the sea. Contrary to swarm control in aviation, the fluid density of the sea is high, and the environment is constantly changing; thus, a robot system would be significantly affected by disturbances. This ultimately influences the maintenance of swarm formations and the accomplishment of missions [1,2]. Therefore, it is difficult to control numerous moving objects while maintaining a formation at sea by using the existing aerial drone swarm control technology. To solve this problem, we learned a long short-term memory (LSTM) model with time-series marine environmental data to predict maritime disturbances. Thereafter, the model was applied to a mission-based position control algorithm of each USV constituting the swarm to design a marine unmanned floating vessel swarm control system that can be applied to various marine environments. Specifically, to effectively control numerous small USVs for marine research purposes, ocean currents are learned using the LSTM algorithm, and the predicted ocean currents are used to generate a swarm USV control system for USV formations. In this study, a control system model of several small USVs equipped with two rear thrusters and a front lateral thruster was designed. The LSTM algorithm was learned using the previous ocean current data, and the velocity of the following ocean currents was predicted. The predictions were then used as a system disturbance to determine the thrust of the controller. To measure ocean currents in the sea when each USV moves, the velocity, azimuth, and position (latitude, longitude) data from the GPS mounted on the USV were used to measure the velocity and direction of the hull's movement. Further, the flow rate was measured using a flow rate sensor on a small USV. The USV movement and position were controlled using an artificial neural network-PID (ANN-PID) controller. This study entailed a comparative analysis of the designed USV model results and those generated by the simulator, including the behavior control rule of the USV swarm and the path of the actual USV swarm at sea. It was verified that the effectiveness of the USV mathematical model and behavior control rules. By comparing the movement path of the swarm USV with and without the disturbance learning algorithm and ANN-PID control algorithm applied to the designed simulator, the position error and maintenance performance of the swarm formation were analyzed, and the application results were compared.

Preprint REVIEW | doi:10.20944/preprints202001.0353.v1

Chromothripsis and DNA-repair Disorders

Lusine Nazaryan-Petersen, Victoria Alexandra Bjerregaard, Finn Cilius Nielsen, Niels Tommerup, Zeynep Tümer

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: chromothripsis; structural variants; DNA-repair; DNA-repair disorders; DNA-double strand breaks (DSBs); ataxia telangiectasia mutated (ATM); ataxia-telangiectasia and Rad3-related (ATR); TP53; micronuclei; chromosome pulverization.

Online: 29 January 2020 (11:58:58 CET)

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Preprint REVIEW | doi:10.20944/preprints202406.0233.v1

Vaginal Microbiome and Pregnancy Complications: A review

Angeliki Gerede, Konstantinos Nikolettos, Eleftherios Vavoulidis, Chrysoula Margioula-Siarkou, Stamatios Petousis, Maria Giourga, Panagiotis Fotinopoulos, Maria Salagianni, Sofoklis Stavrou, Konstantinos Dinas, Nikolaos Nikolettos, Ekaterini Domali

Subject: Biology And Life Sciences, Life Sciences Keywords: Keywords: Vaginal Microbiome; Pregnancy Complications; Preterm birth; Miscarriage; Gestational Diabetes Mellitus; Preeclampsia; Chorioamnionitis; Ectopic pregnancy; Preterm Premature Rapture of Membranes

Online: 5 June 2024 (10:44:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0229.v1

The Interplay between Vitamin D Deficiency, Iron Status, and Anemia Risk in Moroccan Women of Reproductive Age: A Cross-Sectional Analysis

Noura Zouine, Ilham Lhilali, Lode Godderis, Adil El Midaoui, Samir El Jaafari, Younes Filali-Zegzouti

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Vitamin D; Vitamin D deficiency; iron deficiency; iron deficiency anemia, anemia; erythropoiesis; dietary intake; women of reproductive age

Online: 3 September 2024 (14:37:12 CEST)

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Vitamin D and iron deficiencies are the most prevalent micronutrient deficiencies among women of reproductive age (WRA) in Morocco. Recent studies suggest that Vitamin D deficiency (VDD) may reduce iron bioavailability necessary for erythropoiesis, potentially leading to iron deficiency (ID) and anemia. This study investigates the association between vitamin D status, iron levels, and anemia risk among Moroccan WRA aged 18-49 years. A cross-sectional study was conducted with 463 participants. Serum levels of 25(OH)D, blood count parameters, iron, ferritin, C-reactive protein, and creatinine were measured. Lifestyle factors, including dietary intake, sun exposure, and physical activity, were evaluated using validated questionnaires, and anthropometric data were collected. Linear and logistic regression models assessed the relationships between variables, while Receiver Operating Characteristic (ROC) curve analysis evaluated the predictive accuracy of VDD for ID and anemia. VDD (25(OH)D < 20 ng/ml) was significantly associated with lower levels of hemoglobin, hematocrit, red blood cells, and ferritin (all p < 0.01), suggesting a role of vitamin D in erythropoiesis and iron storage. Multivariate logistic regression showed that VDD increased the risk of anemia (OR: 7.17, 95% CI: 3.19-19.28, p < 0.001), ID (OR: 2.20, 95% CI: 1.32-3.77, p = 0.007), and IDA (OR: 4.10, 95% CI: 1.73-12.08, p = 0.004). Dietary iron intake was inadequate among all participants, with minimal protective effect against anemia and ID (β(SE): -0.08(0.03), p = 0.030 and β(SE): -0.05(0.02), p=0.037 respectively). ROC analysis demonstrated moderate discriminative power for VDD in diagnosing IDA and anemia (AUC: 0.643 and 0.603) but reduced accuracy for ID (AUC: 0.575). This study identifies VDD as a significant risk factor for impaired iron status and anemia among Moroccan WRA, underscoring the need for targeted nutritional interventions and further research to explore effective prevention strategies.

Preprint ARTICLE | doi:10.20944/preprints202409.1083.v1

Integrating YOLOv5, Jetson Nano, and Mitsubishi Manipulator for Real-time Machine Vision Application in Manufacturing

Ardian Webi Kirda, Paweł Majewski, Gerard Bursy, Marian Bartoszuk, Hayati Yassin, Grzegorz Krolczyk, Nur Arifin Akbar, Wahyu Caesarendra

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: automated chamfering and grinding; deep learning; intelligent manufacturing and remanufacturing; machine vision; robotic manufacturing

Online: 13 September 2024 (11:50:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0528.v1

Four-Channel Integrated High-Voltage Power Supply for Dielectric Elastomer Actuators

Haoyue Xing, Qun Hao, Cancan Yao, Zitong Zhang, Jiafu Li, Yang Cheng

Subject: Engineering, Electrical And Electronic Engineering Keywords: Dielectric elastomer actuators; Electric amplifier; High voltage; DC-DC converter

Online: 6 September 2024 (10:57:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1568.v1

Fostering Intrinsic Motivation and Mental Well-being in Today’s Systems

Fayyaz Qureshi, Sarwar Khawaja, Katarina Sokić, Mirjana Pejić Bach, Maja Meško

Subject: Social Sciences, Education Keywords: motivation; intrinsic motivation; mental well-being; UK mature students

Online: 23 May 2024 (16:55:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0142.v1

The Effects of PM_2.5 from Asian Dust Storms on Emergency Room Visits for Cardiovascular and Respiratory Diseases

Ssu-Ting Liu, Chu-Yung Liao, Hsien-Wen Kuo

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Air pollution, PM2.5, emergency room, Asian dust storms, case-crossover

Online: 17 March 2017 (18:13:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.0993.v1

Follow-Up Period Affects the Association between Serum 25-Hydroxyvitamin D Concentration and Incidence of Dementia, Alzheimer’s Disease, and Cognitive Impairment

William B. Grant

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Alzheimer’s disease; cognitive impairment; dementia; follow-up period; neurological conditions; risk; vitamin D deficiency

Online: 14 August 2024 (09:35:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1418.v2

Cancer Incidence Rates in the US in 2016–2020 with Respect to Solar UVB Doses, Diabetes and Obesity Prevalence, Lung Cancer Incidence Rates, and Alcohol Consumption: An Ecological Study

William B. Grant

Subject: Public Health And Healthcare, Other Keywords: alcohol consumption; cancer incidence; diabetes mellitus; diet; ecological study; lung cancer; obesity; solar UVB, USA; vitamin D

Online: 7 May 2024 (11:57:17 CEST)

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Abstract: This article reports the results of an ecological study of cancer incidence rates by state in the US for the period 2016-2020. The goals of this study were to determine the extent to which solar UVB doses still reduced cancer risk compared to findings reported in 2006 for cancer mortality rates for the periods 1950–1969 and 1970-1794 as well as cancer incidence rates for the period 1998–2002 and to determine which factors were recently associated with cancer risk. The cancer data for non-Hispanic white (European American) men and women were obtained from the Centers for Disease Control and Prevention. Indices were obtained for solar UVB at the surface for July 1992, and alcohol consumption, and diabetes and obesity prevalence near the 2016–2020 period. Lung cancer incidence rates were also used in the analyses as a surrogate for smoking, diet, and air pollution. The cancers for which solar UVB is significantly associated with reduced incidence are bladder, brain (males), breast, corpus uteri, esophageal, gastric, non-Hodgkin’s lymphoma, pancreatic, and renal cancer. Lung cancer was significantly associated with colorectal, laryngeal, and renal cancer. Diabetes was also significantly associated with breast, liver, and lung cancer. Obesity prevalence was significantly associated with breast, colorectal and renal cancer. Alcohol consumption was associated with bladder and esophageal cancer. Thus diet has become a very important driver of cancer incidence rates. The role of solar UVB in reducing risk of cancer has been reduced due to people spending less time outdoors, wearing sunscreen that blocks UVB but not UVA radiation, and population increases in overweight and obesity, which lowers 25-hydroxyvitamin D concentrations and generates systemic inflammation, a risk factor for cancer. The dietary approach that would reduce the risk of diabetes, obesity, lung cancer, and, therefore cancer, would be one based mostly on whole-plants and restrictions on red and processed meats and ultraprocessed foods. Solar UVB exposure for a few minutes before applying sunscreen and taking vitamin D supplements would also help reduce risk of cancer.Keywords: alcohol consumption; cancer incidence;

Preprint COMMUNICATION | doi:10.20944/preprints202405.0336.v1

Nano(bio)materials Do Not Affect Macrophage Phenotype – A Study Conducted by the REFINE Project

Christopher A.W. David, Jolanda P. Vermeulen, Sabrina Gioria, Rob J. Vandebriel, Neill J. Liptrott

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Monocyte-derived macrophages; Nanostructured lipid carrier; Polymeric nanomedicine; Immunotoxicity assessment

Online: 7 May 2024 (08:17:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0961.v1

The Preventive Potential of the Mycelial Submerged Culture of Ophiocordyceps sinensis against Neurodegenerative Diseases and Its Possible Active Compounds

Hsien-Chi Huang, Yu-Juan Shi, Thuy-Lan-Thi Vo, Tai-Hao Hsu, Tuzz-Ying Song

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: Ophiocordyceps sinensis; neurodegenerative disease; microglial; anti-inflammatory; cytokines; submerged culture

Online: 15 April 2024 (11:29:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0873.v1

Influenza Vaccine Hesitancy among Healthcare Workers in a Northeastern Province in Thailand: Findings of a Cross-Sectional Survey

Manash Shrestha, Penchan Pradubmook Sherer, Seung Chun Paek, Kriengkrai Prasert, Sutthinan Chawalchitiporn, Prabda Praphasiri

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: influenza vaccine,; healthcare workers; vaccine hesitancy; Thailand

Online: 15 March 2024 (11:17:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.1489.v1

Clinical Impact of Systematic Assessment and Psychoeducation in Specialized Treatment of Adolescents with Severe Functional Somatic Disorders: Results from the AHEAD Study

Karen Hansen Kallesøe, Kaare Bro Wellnitz, Eva Ørnbøl, Charlotte Ulrikka Rask

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Adolescents; Assessment; Functional Somatic Disorders; Functional Somatic Syndromes; Psychoeducation

Online: 22 May 2023 (09:44:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0508.v1

Efficacy of Different Dietary Patterns in the Treatment of Functional Gastrointestinal Disorders in Children and Adolescents. A Systematic Review of Intervention Studies

Christina N. Katsagoni, Vasiliki-Maria Karagianni, Alexandra Papadopoulou

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Functional gastrointestinal disorders; IBS; dyspepsia; constipation; abdominal pain; low-FODMAP diet; fructose or lactose restricted diet; gluten-free diet; Mediterranean diet

Online: 8 May 2023 (10:17:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1465.v1

Evaluating the User Experience and Usability of the MINI Robot for Elderly Adults with Mild Dementia and Mild Cognitive Impairment: Insights and Recommendations

Aysan Mahmoudi Asl, José Miguel Toribio-Guzmán, Álvaro Castro-González, María Malfaz, Miguel Ángel Salichs, Henriëtte Van der Roest, Manuel Franco-Martín

Subject: Social Sciences, Psychiatry And Mental Health Keywords: usability; user experience; social robots; dementia; mild cognitive impairments

Online: 20 August 2024 (12:24:51 CEST)

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Background: In recent years, the integration of robotic systems into various aspects of daily life has become increasingly common. As these technologies continue to advance, ensuring user-friendly interfaces and seamless interactions becomes more essential. For social robots to genuinely provide lasting value to humans, a favourable user experience (UX) emerges as an essential prerequisite. Aim: This article aimed to evaluate the usability of the MINI robot, highlighting its strengths and areas for improvement based on user feedback and performance. Method: In a controlled lab setting, a mixed-method qualitative study was conducted with ten individuals aged 65 and above diagnosed with mild dementia (MD) and mild cognitive impairment (MCI). Participants engaged in individual MINI robot interaction sessions, completing cognitive tasks as per written instructions. Video and audio recordings documented interactions, while post-session System Usability Scale (SUS) questionnaires quantified usability perception. Ethical guidelines were followed, ensuring informed consent, and the data underwent qualitative and quantitative analyses, contributing insights into the MINI robot's usability for this demographic. Results: The study addresses the ongoing challenges that tasks present, especially for MD individuals, emphasizing the importance of user support. Most tasks require both verbal and physical interactions, indicating that MD individuals face challenges when switching response methods within subtasks. These complexities originate from the selection and use of response methods, including difficulties with voice recognition, tablet touch, and tactile sensors. These challenges persist across tasks, with individuals with MD struggling to comprehend task instructions and provide correct answers and individuals with MCI struggling to use response devices, often due to the limitations of the robot's speech recognition. Technical shortcomings have been identified. The results of the System Usability Scale (SUS) indicate positive perceptions, although there are lower ratings for instructor assistance and pre-use learning. The average SUS score of 68.3 places device usability in the "good" category. Conclusion: Our study examines the usability of the MINI robot, revealing strengths in quick learning, simple system and operation, and integration of features while also highlighting areas for improvement. Careful design and modifications are essential for meaningful engagement with people with dementia. The robot could better benefit people with MD and MCI if clear, detailed instructions and instructor assistance are available.

Preprint ARTICLE | doi:10.20944/preprints202403.0036.v1

Nerve Growth Factor Shows Biphasic Expression during Adjuvant-Induced Neurogenic Inflammation

Vikramsingh Gujar, Radhika Dilip Pande, Subhas Das

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: inflammation; nerve growth factor (NGF); neurogenic Inflammation; acute inflammation; Nociception; NGF-TrkA signaling; Biphasic

Online: 4 March 2024 (06:02:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0963.v1

CBD-X Extracts in Asthma Management: Reducing Th2-Driven Cytokine Secretion and Neutrophil/Eosonophil Activity

Miran Aswad, Antonina Pechkovsky, Narmeen Ghanayiem, Yaniv Dotan, Igal Louria-Hayon

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: CBD extracts; asthma; type 2 helper T cells (Th2); neutrophil; Eosonophil; OVA-Induced Asthmatic mouse model; cytokines; migration; IgE

Online: 12 September 2024 (05:35:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1505.v1

Efficacy and Safety in Dogs Following Administration of an Alphavirus RNA Particle Canine Influenza H3N2 Vaccine

Haley Marie Classe, Jennifer Dant, Mark Mogler, Ken Stachura, Rhonda LaFleur, Zach Xu, Ian Tarpey

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: canine; influenza; H3N2; vaccine; efficacy; safety; shedding

Online: 21 August 2024 (08:45:07 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202406.0419.v1

“A Retrospective Cross-Sectional Analysis of Viral Sari in Pregnant Women in Southern Brazil”

Sonia Maria Lissa, Bruna Amaral Lapinski, Maria Ester Graf, Somaia Reda, Maria Do Carmo Debur, Mayra Presibella, Luciane Aparecida Pereira, Newton Sergio De Carvalho, Jaqueline Carvalho de Oliveira, Sonia Mara Raboni, Meri Bordignon Nogueira

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: pregnant women; SARI; influenza; viral infections; respiratory infections.

Online: 10 June 2024 (12:40:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1018.v1

Management of Short Bowel Syndrome/Chronic Intestinal Failure – the Experience of a Single Portuguese Center

Marisa Domingues Santos, Vânia Magalhães, Luís Loureiro, Pedro Pina, Ana Castro, Paulina Aguiar, Ana Gomes, Diana Soares, Anabela Rocha

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Keywords; Short bowel Syndrome; Chronic Intestinal failure; Home Parenteral Nutrition; Teduglutide; Complications of Parenteral Support

Online: 19 February 2024 (16:24:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints201611.0089.v1

Estimation of the Daily Salt Intake by 24-Hour Urinary Sodium Excretion in Morocco: A Pilot Study

Abdelfettah Derouiche, Younes El-Kardi, Karima Mohtadi, Ali Jafri

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: hypertension; salt intake; urinary excretion; Morocco

Online: 17 November 2016 (10:49:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0133.v1

Calorie Restriction Supplemented with Fish Oil Ameliorates Abnormal Metabolic Status in Middle-Aged Obese Women: An Open-Label, Parallel-Arm, Controlled Trial

Fasty Arum Utami, Hsiu-Chuan Lee, Chien-Tien Su, Shih-Yi Huang

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: calorie restriction; PUFA; meal replacement; metabolic syndrome; middle age

Online: 13 August 2016 (03:39:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1606.v1

Identification of Stage-Specific microRNAs That Govern the Early Stages of Sequential Oral Oncogenesis by Strategically Bridging Genetics and Epigenetics

Iphigenia Gintoni, Stavros Vassiliou, George Chrousos, Christos Yapijakis

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Oral squamous cell carcinoma; OSCC; oral cancer; miRNA; miRNA expression; genes; gene expression; hyperplasia; dysplasia; early invasion; early stage OSCC; in situ carcinoma; precancerous lesions; animal model; early diagnosis; liquid biopsy

Online: 24 May 2024 (08:38:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1124.v1

The Role of Personal and Environmental Resources in Predicting Work-Family Facilitation and Mental Health Among Employed Parents of Children With Disabilities in Croatia

Ana Šimunić, Ana Slišković, Andrea Tokić, Jelena Ombla, Lisa Stewart

Subject: Social Sciences, Psychology Keywords: parents of children with disabilities; mental health; work-family facilitation; emotional regulation strategies; optimism; posttraumatic growth; social support; recovery management

Online: 18 July 2023 (13:42:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0580.v1

Physical Activity, Mental Health and Wellbeing of Irish Adolescents during Covid-19 Restrictions. A Re-Issue of the Physical Activity and Wellbeing Study (PAWS)

John Murphy, Bronagh McGrane, Mary Rose Sweeney

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Exercise; Sport; Team Sport; Resilience; Identity; Health; School

Online: 26 July 2021 (14:24:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0341.v1

Prevalence and Factors Associated with Mental and Emotional Health Outcomes among Africans during the COVID-19 Lockdown Period - A Web-Based Cross-Sectional Study

Raymond Langsi, Uchechukwu Levi Osuagwu, Piwuna Christopher Goson, Emmanuel Kwasi Abu, Khathutshelo Percy Mashige, Bernadine Ekpenyong, Godwin O Ovenseri-Ogbomo, Timothy G Chikasirimobi, Chundung Asabe Miner, Tanko Ishaya, Richard Oloruntoba, Obinna Nwaeze, Deborah Donald Charwe, Kingsley Agho

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; sub-Saharan Africa; mental health; feeling anxious; worried; frustrated; psychological problem; bored and angry

Online: 18 January 2021 (13:56:06 CET)

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Mental health and emotional responses to the effects of COVID-19 lockdown in sub-Saharan Africa (SSA) are of serious public health concern and may negatively affect the mental health status of people. Hence, this study assessed the prevalence of mental health symptoms as well as emotional reactions among sub-Saharan Africans (SSAs) and associated factors among SSAs during the COVID-19 lockdown period. This was a web-based cross-sectional, a study on mental health and emotional features from 2005 respondents in seven SSA countries. This study was conducted between April 27 and May 17, 2020 corresponding to the lockdown period in most SSA countries. Respondents aged 18 years and above and the self-reported symptoms were feeling anxious, being worried, angry, bored and frustrated. These were the main outcomes and were treated as dichotomous variables. Univariate and multivariate logistic regression analyses were used to identify the factors associated with these symptoms. We found that over half (52.2%) of the participants reported any of the mental health symptoms in SSA and the prevalence of feeling bored was 70.5% followed by feeling anxious (59.1%), being worried (57.5%), frustrated (51.5%) and angry (22.3%) during the COVID-19 pandemic. Multivariate analysis revealed that males, those aged >28 years, Central and Southern Africans, those who were not married, the unemployed, those living with more than six persons in a household, had higher odds of mental health and emotional symptoms. Similarly, people who perceived low risk of contracting the infection, and those who thought the pandemic would not continue after the lockdown had higher odds of mental health and emotional symptoms. Health care workers had lower odds for feeling angry than non-healthcare workers. During COVID-19 lockdown periods in SSA, about one in two participants reported mental health and emotional symptoms. Public health measures can be effectively used to identify target groups for prevention and treatment of mental health and emotional symptoms. Such interventions should be an integral component of SSA governments’ response and recovery strategies of any future pandemic.

Preprint ARTICLE | doi:10.20944/preprints202409.0533.v1

Exploring the Dual Benefits of Fermented and Non-fermented Garlic on Growth, Antioxidative Capacity, Immune Responses, and Histology in Grey Mullet (Liza ramada)

Mohammed F. El Basuini, Mahasen M. E. A. Shaban, Abdelaziz M. El-Hais, Ali A. Soliman, Nermeen M. Abu-Elala, Islam I. Teiba, Mayada Alhoshy, Ghada R. Sallam, Ronick S. Shadrack, Kumbukani Mzengereza, Akram Ismael Shehata

Subject: Biology And Life Sciences, Aquatic Science Keywords: Allium sativum; Antioxidant status; Digestive enzymes; Feed additives; Fermented garlic; Growth performance; Liza ramada

Online: 6 September 2024 (11:11:47 CEST)

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This study investigated the effects of dietary garlic powder and fermented garlic powder supplementation at 1% and 2% levels on growth performance, digestive tract efficacy, blood biochemistry, immunity, and antioxidant status of Liza ramada (n=225 fish; 86.00±0.42 g) over a 60-day period. Fish fed diets supplemented with both forms of garlic at both levels exhibited significantly improved final body weight, weight gain, specific growth rate, and feed conversion ratio compared to the control group. Digestive enzyme activities (amylase, lipase, and protease) were significantly enhanced in all supplemented groups. Blood biochemical analysis revealed reduced glucose levels and increased total protein in garlic-supplemented groups, with no adverse effects on liver or kidney function markers. Immune parameters, including lysozyme activity, bactericidal activity against Streptococcus agalactiae, alternative complement pathway (ACP), and, respiratory burst (NBT) were significantly enhanced in garlic-supplemented groups, with fermented garlic showing more pronounced effects. Antioxidant enzyme activities (SOD, CAT, and GPx) were also significantly increased in all supplemented groups, particularly in those fed fermented garlic. No significant differences in survival rates were observed among treatments. The results suggest that both garlic powder and fermented garlic powder supplementation, especially at the 2% level, can effectively improve growth, feed utilization, immune function, and antioxidant status in L. ramada. Fermented garlic generally demonstrated superior effects, indicating its potential as a beneficial feed additive in aquaculture. Based on these findings, it is recommended to incorporate fermented garlic powder at a 2% level in L. ramada diets to optimize growth performance and health status. Further research is warranted to investigate the long-term effects and cost-effectiveness of this supplementation strategy in commercial aquaculture settings.

Preprint REVIEW | doi:10.20944/preprints202406.0864.v1

Integrated Photonic Sensors for The Detection of Toxic Gases - A Review

Muhammad A. Butt, Ryszard Piramidowicz

Subject: Physical Sciences, Optics And Photonics Keywords: Gas sensor; integrated photonic sensor; evanescent field absorption; functional material

Online: 12 June 2024 (16:16:14 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202402.1325.v1

Trans-eQTLs Can Be Used to Untangle the Problem of Coexpression-Causality

Majid Nikpay

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: trans-eQTLs; coexpression; causality; TWAS; multiomics; GWAS

Online: 23 February 2024 (08:37:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0556.v1

Angling for Causality behind Security: Natural Causes of Armed Conflict in Iraq

Ninoslav Malekovic, Maarten Vonk, Laura Birkman, Tim Sweijs, Anna Kononova, Thomas Baeck

Subject: Social Sciences, Government Keywords: Causality; Methodology; Conflict modeling; Non-experimental observations

Online: 9 February 2024 (07:25:42 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202408.0459.v1

Towards early cancer detection: the use of Caenorhabditis elegans chemotaxis to distinguish patient urine from that of healthy individuals

Alžbeta Kaiglová, Patrícia Hockicková, Zuzana Bárdyová, Radka Reháková, Kamila Melnikov, Soňa Kucharíková

Subject: Biology And Life Sciences, Life Sciences Keywords: Caenorhabditis elegans; cancer; chemotaxis; chemotactic tests

Online: 6 August 2024 (14:52:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201611.0049.v1

Vitamin-D Deficiency Predicts Infections in Young North Indian Children: A Secondary Data Analysis

Ranadip Chowdhury, Sunita Taneja, Nita Bhandari, Bireshwar Sinha, Ravi Upadhyay, Maharaj Kishan Bhan, Tor A. Strand

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: vitamin-D deficiency; ALRI; Indian children

Online: 8 November 2016 (10:40:34 CET)

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Preprint ESSAY | doi:10.20944/preprints202408.0675.v1

Research on Fault Diagnosis Method with Adaptive GTO Optimized VMD and SVM Parameters

Ting Fang, Long Ma, Hongkai Zhang

Subject: Engineering, Mechanical Engineering Keywords: variational mode decomposition; support vector machine; artificial gorilla troops optimization; fault diagnosis

Online: 9 August 2024 (09:02:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0859.v1

Comorbidity of Type 2 Diabetes and Dementia Among Hospitalized Patients in Los Angeles County, 2019-2021

D’Artagnan M. Robinson, Dalia Regos-Stewart, Mariana A Reyes, Tony Kuo, Noel C Barragan

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: diabetes; Alzheimer’s disease; dementia; hospitalization

Online: 13 October 2023 (08:26:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0018.v1

1H NMR Based Serum Metabolic Profiling Reveals Differentiating Biomarkers in Patients with Diabetes and Diabetes Comorbidity

Atul Rawat, Gunjan Misra, Madhukar Saxena, Sukanya Tripathi, Durgesh Dubey, Sulekha Saxena, Avinash Aggarwal, Varsha Gupta, M Y Khan, Anand Prakash

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Nuclear Magnetic Resonance Spectroscopy, Metabolomics, Biomarker, Random Forest.

Online: 1 August 2018 (11:30:39 CEST)

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Background: Diabetes is among the most prevalent diseases worldwide, of all the affected individuals a significant proportion of the population remains undiagnosed because of a lack of specific symptoms early in this disorder and inadequate diagnostics. Diabetes and its associated sequela, i.e., comorbidity are associated with microvascular and macrovascular complications. As diabetes is characterized by an altered metabolism of key metabolites and regulatory pathways. Metabolic phenotyping can provide us with a better understanding of the unique set of regulatory perturbations that predispose to diabetes and its associated comorbidities. Methodology: The present study utilizes the analytical platform NMR spectroscopy coupled with Random Forest statistical analysis to identify the discriminatory metabolites of diabetes (DB) and diabetes-related comorbidity (DC) along with the healthy control (HC) subjects. A combined and pairwise analysis was performed, between the serum samples of HC (n=50), and DB (n=38), and DC (n=35) individuals to identify the discriminatory metabolites responsible for class separation. The perturbed metabolites were further rigorously validated using t-test, AUROC analysis to examine the statistical significance of the identified metabolites. Results: The DB and DC patients were well discriminated from HC. However, 15 metabolites were found to be significantly perturbed in DC patients compared to DB, the identified panel of metabolites are TCA cycle (succinate, citrate), methylamine metabolism (trimethylamine, methylamine, betaine), -intermediates; energy metabolites (glucose, lactate, pyruvate); and amino acids (valine, arginine, glutamate, methionine, proline and threonine). The metabolites were further used to identify the perturbed metabolic pathway and correlation of metabolites in DC patients. Conclusion: The 1H NMR metabolomics may prove a promising technique to differentiate and predict diabetes and its comorbidities on their onset or progression by determining the altered levels of the metabolites in serum.

Preprint ARTICLE | doi:10.20944/preprints202405.0082.v1

Challenges of Tuberculosis Screening and Existing Gaps in Contact Investigations in Oyo and Osun States, Nigeria

Aderonke Agbaje, Patrick Dakum, Olugbenga Daniel, Anyaike Chukwuma, Obioma Chijoke-Akaniro, Evaezi Okpokoro, Samuel Akingbesote, Christian Anyomi, Adekola Adekunle, Abiola Alege, Moroof Gbadamosi, Olutunde Babalola, Mensah Charles, Rupert Eneogu, Austin Ihesie, Debby Nongo, Ademola Adelekan

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Tuberculosis; Contact investigation; Challenges; Existing gaps

Online: 1 May 2024 (16:47:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1811.v1

Pricing and Financing Strategies of Dual-Channel Green Supply Chain with Risk Aversion and Consumer Preferences

Maojun Zhang, Jiaqi Li, Feifei Liu, Jiangxia Nan, Jiawen Jiang

Subject: Social Sciences, Decision Sciences Keywords: dual channel; capital constraint; risk aversion; consumer preference

Online: 28 May 2024 (07:22:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1084.v1

Histology of the Primary Tumor, Lymph Node, and Tumor Size upon Neoadjuvant Treatment Predict Effectiveness of Complete Pathologic Response in Patients Undergoing Primary Lung Cancer Resections

Fuad Damirov, Mircea Gabriel Stoleriu, Farkhad Manapov, Enole Boedeker, Sascha Dreher, Sibylle Gerz, Thomas Hehr, Evelin Sandner, German Ott, Rudolf Alexander Hatz, Gerhard Preissler

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: lung cancer; PET/CT-scan; lymph node staging; neoadjuvant therapy; pathological response; tumor regression; overall survival

Online: 15 July 2024 (13:04:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0066.v1

Nutritional Assessment, Body Composition and Low Energy Availability in Sport Climbing Athletes of Different Genders and Categories: A Cross-Sectional Study

Agustin Mora-Fernandez, Andrea Argüello-Arbe, Andrea Tojeiro-Iglesias, Jose Antonio Latorre, Javier Conde-Pipó, Miguel Mariscal-Arcas

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: nutrition assessment; sport climbing; bouldering; rock climbing; low energy availability; dietary intake; relative energy deficiency in sport

Online: 2 August 2024 (03:58:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0175.v1

Is There an Association between Environmental Tobacco Smoke Exposure and the Risk of Wheezing among Rural and Urban Preschool Children in Mpumalanga Province, South Africa?

Rodney Mudau, Joyce Shirinde, Kuku Voyi

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Environmental tobacco smoke exposure; The risk of wheezing; Poor air quality; Preschool children

Online: 6 March 2024 (04:12:03 CET)

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Preprint REVIEW | doi:10.20944/preprints202406.0695.v1

Impact of Instagram on the Physical and Mental Well-Being of Indian Youth: A Critical Review

Dr. Bharat Dhiman

Subject: Social Sciences, Media Studies Keywords: Instagram; Social media; Indian youth; Mental well-being; Mental health; Body dysmorphia

Online: 11 June 2024 (12:40:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.0047.v1

Multifactorial Contributors to the Longevity of Dental Restorations: An Integrated Review of Related Factors

Maria Jacinta Moraes Coelho Santos, Elham Zare, Peter McDermott, Gildo Coelho Santos Jr.

Subject: Public Health And Healthcare, Other Keywords: dental restorations; longevity; tooth-related factors; patient-related factors,; dentist-related factors; restoration failure; direct restorations; amalgam; composite resin; glass ionomer cement

Online: 1 July 2024 (08:32:55 CEST)

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Purpose: This integrated review aims to identify and analyze the multifactorial contributors to the longevity of direct restorations, focusing on tooth-, patient-, and dentist-related factors. Materials and Methods: A literature search was performed using an electronic database, PubMed/Medline, Web of Science, and Scopus, between 1980 and 2024. Titles and abstracts of papers that evaluated aspects categorized into tooth-related, patient-related, and dentist-related factors influencing restoration failure were selected and screened. Full-text assessments were conducted, and the extracted data were compiled, summarized, and synthesized. The reference lists of the collected papers were also screened, and relevant citations were included in this review. Data were gathered from clinical and laboratorial studies, systematic reviews, and meta-analyses to provide a comprehensive understanding of restoration longevity. Results: Among the tooth-related factors, multiple-surface restorations, deep margins, tooth location, and tooth vitality significantly impact restoration survival. Patient-related factors such as medical conditions, risk predictors of caries, age, sex, parafunctional habits, smoking, periodontal health, number of restorations, and socioeconomic status all play crucial roles. Regarding dentist-related factors, the decision-making process, age, experience, and dentist manual dexterity are vital aspects. Furthermore, the technique used, including isolation methods for moisture control, as well as the type of dental practice (large group vs. small practice), notably influenced the restoration survival. Conclusions: The longevity of dental restorations is influenced by a complex interplay of tooth-related, patient-related, and dentist-related factors. Strategies to improve restoration outcomes should consider all these multifactorial contributors. Continuing professional education, diligent patient guidance on the factors that influence restoration survival, careful material selection and restorative technique, and tailored individual treatment are crucial factors to reduce failure rates and improve the lifespan of restorations.

Preprint ARTICLE | doi:10.20944/preprints202407.1815.v1

An Integrated Approach Based on Clinical Data Together with Metabolites and Biomarkers for the Assessment of the Postoperative Complications after Cardiac Surgery

Peter Meinarovich, Alisa Pautova, Evgenii Zuev, Ekaterina Sorokina, Ekaterina Chernevskaya, Natalia Beloborodova

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: aromatic microbial metabolites; sepsis-associated metabolites; 4-hydroxyphenyllactic acid; prognostic models; SOFA

Online: 23 July 2024 (16:04:39 CEST)

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Background: Early diagnosis of postoperative complications is an urgent task, allowing timely prescribing of appropriate therapy and reducing the cost of patient treatment. Prognostic models based on various data could help in the early diagnosis of postoperative complications after cardiac surgery. Objectives: The purpose of the study was to determine whether an integrated approach based on clinical data along with metabolites and biomarkers had greater predictive value than the models built on less data. Methods: The study included patients (n=62) admitted for planned cardiac surgery (coronary artery bypass grafting with cardiopulmonary bypass), who were retrospectively divided into two groups depending on the presence (n=26) or absence (n=36) of postoperative complications of all types. Clinical and laboratory data on the first day after surgery were analyzed. Additionally, patients' blood samples were collected before and on the first day after surgery to determine biomarkers (interleukin-6, procalcitonin, NT-proBNP, high-sensitivity troponin T) and metabolites (8 aromatic and 2 dicarboxylic acids were detected using gas chromatography-mass spectrometry). Results: Patients before surgery, compared with healthy donors, differed in the concentration of metabolites (p < 0.05), and had concentrations of a number of biomarkers exceeding the corresponding reference values. Multivariate PLS-DA models, predicting the presence or absence of postoperative complications, were built using clinical data (ROC-AUC=0.71), concentrations of metabolites and biomarkers (ROC-AUC=0.60), and the entire data set (ROC-AUC=0.75). For comparison we built univariate models using the EuroScore2 (ROC-AUC=0.59) and SOFA (ROC-AUC=0.76) scales; concentrations of lactate (ROC-AUC=0.71), the dynamic changes of 4-hydroxyphenyllactic acid (ROC-AUC=0.69), and the sum of three sepsis-associated metabolites (ROC-AUC=0.70). The proposed complex model using entire data set was comparable to the SOFA scale, which confirms the expediency of searching for new predictive models based on a variety of factors.

Preprint ARTICLE | doi:10.20944/preprints202403.1824.v1

Dipeptidyl Peptidase 9 (DPP9) Depletion From Hepatocytes in Mice Retards Liver Tumour Growth and Increases Intrahepatic Caspase-1 Activation

Jiali Carrie Huang, Xinlin Linda Tong, Michelle Sui Wen Xiang, Badwi B. Boumelhem, Diarmid P Foulis, Mingchang Zhang, Catriona McKenzie, Geoffrey William McCaughan, Thomas Reinheckel, Hui Emma Zhang, Mark Douglas Gorrell

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: dipeptidyl peptidase 9; serine protease; hepatocellular carcinoma; inflammasome; autophagy; histopathology

Online: 29 March 2024 (08:34:13 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202409.1137.v1

Exploring Dengue Infection in a Vaccinated Individual: Preliminary Molecular Diagnosis and Sequencing Insights

Talita Émile Ribeiro Adelino, Sílvia Helena Sousa Pietra Pedroso, Maurício Lima, Luiz Marcelo Ribeiro Tomé, Natália Rocha Guimarães, Vagner Fonseca, Paulo Eduardo de Souza da Silva, Keldenn Melo Farias Moreno, Ana Cândida Araújo e Silva, Náthale Rodrigues Pinheiro, Carolina Senra Alves de Souza, Luiz Carlos Junior Alcantara, Marta Giovanetti, Felipe Campos de Melo Iani

Subject: Biology And Life Sciences, Virology Keywords: DENV monitoring; next-generation sequencing; genomic surveillance; vaccine breakthrough

Online: 14 September 2024 (11:46:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.2069.v1

A Semi-explicit Algorithm for Parameters Estimation in a Time-Fractional Dual-Phase-Lag Heat Conduction Model

Stanislav Yu. Lukashchuk

Subject: Physical Sciences, Thermodynamics Keywords: non-Fourier heat conduction model; Caputo fractional derivative; inverse problem; parameters estimation; time integral characteristic

Online: 30 May 2024 (14:24:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1145.v1

Manufacturing Strategies for a Family of Integrated Photovoltaic-Fuel Cell Systems

Chukwuma Ogbonnaya, Grace Hegarthy

Subject: Engineering, Energy And Fuel Technology Keywords: Renewable energy technologies; Supply chain management; Lean and agile manufacturing; Modularisation; IPVFC systems; Decarbonisation; Hydrogen; Distributed generation; Manufacturing management; Domain-based thinking; Model-based systems engineering

Online: 15 August 2024 (14:32:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0820.v1

Jerry Vriend, Xiaoqing Liu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: medulloblastoma; gene expression; survival related genes; hazard ratios; chromosome 6; chromosome 17; HMGA1

Online: 13 May 2024 (10:43:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0506.v1

Upper Back Distinguishing Work-Related Musculoskeletal Problems among Quay and Rubber Tyred Gantry Crane Operators Working in Deep-Sea Port

Teerayut Sa-ngiamsak, Anamai Thetkathuek

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: port crane operators; quay crane; rubber tyred gantry crane; work-related musculoskeletal problem; perceived discomfort

Online: 8 May 2024 (14:03:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0833.v1

Design, Synthesis, and Evaluation of Oleyl-WRH Peptides for siRNA Delivery

Mrigank Shekhar Rai, Muhammad Imran Sajid, Jonathan Moreno, Keykavous Parang, Rakesh Kumar Tiwari

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: acylation; arginine; breast cancer; cell-penetrating peptide; histidine; MDA-MB-231; oleic acid; RNA interference; siRNA; SK-OV-3; STAT-3; tryptophan; western blotting

Online: 10 July 2024 (10:51:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.2137.v1

Pregnancy and Risks from Cosmetics

Foteini Biskanaki, Niki Tertipi, Eleni Andreou, Eleni Sfyri, Vasiliki Kefala, Efstathios Rallis

Subject: Social Sciences, Safety Research Keywords: pregnancy; skin; cosmetics; cosmetics’ risks; cosmetic procedures

Online: 27 September 2024 (00:17:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1697.v1

A Study on Graph Optimization Method for GNSS/IMU Integrated Navigation System Based on Virtual Constraints

Haiyang Qiu, Yun Zhao, Hui Wang, Lei Wang

Subject: Engineering, Electrical And Electronic Engineering Keywords: graph optimization; GNSS/IMU integrated navigation; Kalman Filter; SLAM

Online: 27 May 2024 (08:31:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1015.v1

Safety of Dual Orexin Receptor Antagonist Daridorexant: A Dispropor-tionality Analysis of Publicly Available FAERS Data

Giuseppe Cicala, Maria Antonietta Barbieri, Giulia Russo, Francesco Salvo, Edoardo Spina

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Daridorexant; Insomnia; Orexin; Pharmacovigilance databases

Online: 19 February 2024 (16:14:12 CET)

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Preprint REVIEW | doi:10.20944/preprints202405.1641.v1

Probiotic yeasts: a developing reality?

Vivian Tullio

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Yeast probiotics; Promising benefit; Probiotic development; Genetic engineering

Online: 24 May 2024 (11:18:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0453.v1

The Institutionalization of People with Intellectual Disabilities: A Never-Ending Story

Roy McConkey

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Intellectual disability; institutions; ; ; medical model; rights; person-centred; quality of life

Online: 8 May 2024 (10:34:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0380.v1

Research Hotspots and Trend Analysis of Community Public Health Based on CiteSpace and VOSviewer

Pingping Wang, Chenhui Deng, Jin Yao, Yaqiong Li, Xiaorong Huang

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: community public health; Bibliometrics; Visualization; Development trend; CiteSpace; VOSviewer

Online: 4 July 2024 (14:24:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202007.0061.v1

Substance Use Disorder in the COVID-19 Pandemic: A Systematic Review of Vulnerabilities and Complications

Yufeng Wei, Rameen Shah

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: COVID-19; SARS-CoV-2; Coronavirus; Substance Use Disorder (SUD); Immunology; Neuroinflammation; Blood-Brain Barrier (BBB); hypothalamic–pituitary–adrenal (HPA) axis

Online: 5 July 2020 (10:21:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2514.v1

Online and Offline Aggressive Behaviors in Adolescence: The Role of Self-Regulatory Self-Efficacy Beliefs

Ainzara Favini, Carolina Lunetti, Alessia Teresa Virzì, Loreta Cannito, Flavia Culcasi, Tiziana Quarto, Paola Palladino

Subject: Social Sciences, Psychology Keywords: Self-Regulatory Self-Efficacy; Online Aggressions; Aggressive Behaviors; Impulsivity; Adolescence

Online: 31 July 2024 (10:23:20 CEST)

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Self-regulatory Self-efficacy belief (i.e., SRSE) represents a fundamental factor for adjustment in adolescence, as a vehicle to promote positive behaviors and protect youths from transgressions and maladjustment Bandura et al., 2003; LaRose et al., 2010). Research attested that, during adolescence, boys are more vulnerable to externalizing behaviors than girls, especially when they perceive themselves as scarcely capable of managing and orienting their behaviors, and when they possess impairments in impulsivity (Bandura et al., 2001; Muris, 2006). Previous studies firmly supported the key role of SRSE especially in the offline context in adolescence, but very few studies investigated its impact in the online context, although nowadays Internet represents one of the most significant environments for youths’ daily lives (LaRose et al., 2010; Favini et al., 2023). Thus, we aimed to examine the protective moderating role of SRSE in online and offline aggressive behaviors, beyond youths’ temperamental vulnerabilities, such as high levels of impulsivity. A sample of 318 Italian adolescents (Mage=15.21; SD=.51; 57% boys; 40% girls; 3% third gender) were asked to complete the Impulsivity Scale at Wave1, online and offline aggressive behaviors scales at Wave 2, and SRSE at Wave 2. Multiple-group-by-gender moderation model evidenced that, for what concerns online aggression, beyond the direct effects of impulsivity in boys and girls, SRSE directly affected online aggression and mediated the effect of impulsivity in girls. In contrast, impulsivity significantly affected offline aggressive behaviors only indirectly through the effects of SRSE, and SRSE directly influenced these behaviors in both genders. These results hold for the effects of youth’s age, sexual orientation, socioeconomic status, and years of education completed. This work preliminary evidenced that, contrary to previous studies which focused especially on the vulnerability of boys to aggressive conduct, impulsivity had direct effects on online aggressive behaviors in girls, and SRSE can protect adolescents of both genders in the online context, by predicting low online aggression, and represent a protective factor from the indirect effects that im-pulsivity impairments can have also in the offline context.

Preprint ARTICLE | doi:10.20944/preprints202409.2401.v1

Nouns as Essential Migration Signifiers for Improving Migrant Mental Health Through Social Services Supporting Problem-Focused or Emotion-Focused Coping

Carol Nash

Subject: Social Sciences, Anthropology Keywords: migrate; social services; migrants; mental health; nouns; self-direction; coping

Online: 30 September 2024 (10:52:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0008.v1

Factors Associated with Extended Length of Stay for Paediatric Mental Health Presentations to Emergency Departments in South Western Sydney, Australia

Jahidur Rahman Khan, James Rufus John, Paul M. Middleton, Yao Huang, Ping-I Lin, Nan Hu, Bin Jalaludin, Paul Chay, Raghu Lingam, Valsamma Eapen

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: extended length of stay; emergency department; mental health

Online: 1 February 2023 (06:01:41 CET)

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Background: Evidence suggests that children and young people (CYP) who present to the emergency department (ED) for mental health (MH) difficulties may have extended lengths of stay (LOS); however, there is a paucity of research in Australia regarding the factors associated with extended LOS. This study aimed to determine the factors associated with extended LOS for paediatric MH-related presentations to the EDs in South Western Sydney (SWS), a multicultural community in Australia. Methods: We analysed electronic medical records (eMR) of 7,409 MH-related ED encounters of CYP aged 0 up to 18 years from all six public hospitals in SWS from January 2016 to April 2022. Extended LOS was defined as encounters of more than 4 hours. We assessed factors associated with extended LOS using a multilevel logistic regression model, accounting for hospital-level clustering. Results: Approximately 57.6% of all ED presentations for paediatric MH involved extended LOS. ED presentations by adolescents (adjusted odds ratio (AOR) 2.23, 95% CI 1.20-4.17 for 12-14 years and AOR 2.69, 95% CI 1.44-5.00 for 15-17 years), and patients with a preferred language other than English (AOR 1.47, 95% CI 1.15-1.89) had increased odds of extended LOS compared to their counterparts. Deliberate self-harm related presentations, the most commonly presented MH condition, had higher odds of extended LOS than other MH-related presentations (AOR 1.77, 95% CI 1.59-1.98). Patients with MH presentations that required urgent evaluation (triage levels 1-2) had higher odds of extended LOS (AOR 1.38, 95% CI 1.15-1.65) compared to triage level 3, whereas those with triage levels 4-5 had lower odds (AOR 0.66, 95% CI 0.58-0.74). Further, patients with MH-related presentations that came by ambulance (compared to other mode of presentations) and presentations that happened at night and late at night (compared to early morning and daytime presentations). The odds of extended LOS were considerably lower during the COVID-19 period compared to the pre-COVID-19 period (AOR 0.74, 95% CI 0.67-0.82). Additionally, extended paediatric LOS for MH issues in the ED showed notable hospital-level heterogeneity. Conclusion: A large proportion of extended LOS in ED and sociodemographic disparities reflect inequality in access to paediatric MH care. Our findings highlight the need for equitable distribution of resources directed towards at-risk CYP to improve MH outcomes and reduce health system burden.

Preprint ARTICLE | doi:10.20944/preprints202106.0654.v1

A Hybrid Deep Learning Model to Predict the Impact of COVID-19 on Mental Health form Social Media Big Data

Tapotosh Ghosh, Md. Hasan Al Banna, Md. Jaber Al Nahian, Kazi Abu Taher, M Shamim Kaiser, Mufti Mahmud

Subject: Computer Science And Mathematics, Data Structures, Algorithms And Complexity Keywords: COVID-19; Mental Health; Depression; Big data; Social media.

Online: 28 June 2021 (13:50:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0080.v1

Assessing the Level of Mental Health of Medical Staff at a Private Hospital at the Time of Corona Virus Pandemic

Hadi Alimoradi, Mahsa Nazari, Reza Jafari Nodoushan

Subject: Social Sciences, Psychology Keywords: depression; anxiety; social solidarity; corona virus; mental health

Online: 4 August 2020 (08:14:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0045.v1

Effects of Direct-Acting Antiviral Agents on the Mental Health of Patients with Chronic Hepatitis C: A Prospective Observational Study

Michele Fabrazzo, Rosa Zampino, Martina Vitrone, Gaia Sampogna, Lucia Del Gaudio, Daniela Nunziata, Salvatore Agnese, Anna Santagata, Emanuele Durante-Mangoni, Andrea Fiorillo

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Chronic hepatitis C; Direct-acting antiviral agents; Hepatitis C virus; Consultation-liaison psychiatry; Depression; Anxiety

Online: 5 July 2020 (05:15:08 CEST)

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Preprint REVIEW | doi:10.20944/preprints201612.0097.v2

Natural Pathogen Inhibiting Chemistry to Replace Toxic Treatment of Microbes and Biofilm in Cooling Towers ^†

Lon Brouse, Richard Brouse, Daniel Brouse

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: pathogens; Legionella; amoeba; protozoa; biofilm; antibacterial; antimicrobial; cooling towers; biocides; polyvalent metals

Online: 20 December 2016 (10:26:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.0922.v1

An Efficient Process for the Management of Deterioration and Conservation of Architectural Heritage. The HBIM Project of the Duomo of Molfetta (Italy)

Juan Enrique Nieto-Julián, Silvana Bruno, Juan Moyano

Subject: Engineering, Architecture, Building And Construction Keywords: Architectural heritage; Conservation of the Duomo di Molfetta; Deterioration of masonry; HBIM; Semantic segmentation; Scan to BIM

Online: 13 August 2024 (13:10:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1638.v1

Health Prompts Affect Consideration of Health but Not Intertemporal Preferences While Promoting Healthier Food Choices

Olivier Tuyizere, Christopher R. Gustafson, Devin J. Rose

Subject: Social Sciences, Behavior Sciences Keywords: point-of-decision prompt; active health consideration; health promotion; intertemporal preferences; nutrition; food choice

Online: 25 April 2024 (09:23:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0242.v2

Dual-input Dual-stream Network with Two-fold Margin Loss for Improved Brain Tumor Detection on MRI Images

Mumtaz Ali Kaloi, Riaz Ali, Nazim Hussain Hajano, Abdul Sattar Sattar Chan, Irfan Ali Babbar, Asif Ali

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Dual-input; Dual-stream; Two-fold Margin Loss; Brain Tumor Detection; MRI Images

Online: 10 September 2024 (09:04:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0693.v1

miR-1 as a Key Epigenetic Regulator in Early Differentiation of Cardiac Sinoatrial Region

Carlos García-Padilla, Estefanía Lozano-Velasco, Virginio García-López, Amelia Aránega, Diego Franco, Virginio García-Martínez, Carmen López-Sánchez

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: miR-1; epigenetic regulator; cardiac sinoatrial region; molecular mechanisms; HDAC4; Calmodulin; pErk2/MAPK1; Mef2c activity; retinoic acid signaling; cardiac development

Online: 12 March 2024 (10:22:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0221.v1

Dimacrolide Sesquiterpene Pyridine Alkaloids from the Stems of Tripterygium regelii

Dongsheng Fan, Guo-Yuan Zhu, Ting Li, Zhi-Hong Jiang, Li-Ping Bai

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: Tripterygium regelii; dimacrolide sesquiterpene pyridine alkaloids; anti-inflammation

Online: 29 August 2016 (10:46:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0951.v1

Sociodemographic and Clinical Correlates including Psychiatric Comorbidities in Clinical Population of Irritable Bowel Syndrome

Ankita Saroj, Adarsh Tripathi, Sumit Rungta, Sujita Kumar Kar

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Irritable bowel Syndrome; Psychiatric comorbidities; Somatic symptoms; Anxiety; Stress

Online: 18 March 2024 (09:20:22 CET)

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