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Preprint REVIEW | doi:10.20944/preprints202306.1736.v1

Advancements and Insights in Exosome-Based Therapies for Wound Healing: A Comprehensive Systematic Review (2018-June 2023)

Patrícia Sousa, Bruna Lopes, Ana Catarina Sousa, Alícia Moreira, André Coelho, Rui Alvites, Nuno Alves, Stefano Geuna, Ana Colette Maurício

Subject: Medicine And Pharmacology, Other Keywords: animal models; exosomes; skin regeneration; wound healing; systematic review.

Online: 26 June 2023 (04:55:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1726.v1

Investigating the Causal Relationship of Gut Microbiota with Psoriasis and Psoriatic Arthritis: A Bidirectional Two-Sample Mendelian Randomization Study.

Nianzhou Yu, Jiayi Wang, Yuancheng Liu, Yeye Guo

Subject: Medicine And Pharmacology, Dermatology Keywords: Gut Microbiota (GM); Psoriasis (Ps); Psoriatic Arthritis (PsA); Mendelian randomization(MR); Causal effect

Online: 25 June 2023 (08:26:05 CEST)

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Background: Numerous investigations have shed light on the intriguing interplay between gut microbiota(GM) and psoriasis (Ps) as well as psoriatic arthritis (PsA). However, the precise nature of the causal relationship between them remains an area of active investigation. Methods: For the purpose of our investigation, we meticulously curated a collection of genetic variants (P < 1 × 10−5) associated with GM (n = 18,340) derived from the MiBioGen study. To explore the intricate relationship between GM and Ps as well as PsA, we harnessed the comprehensive resources of the FinnGen database, encompassing a vast cohort of individuals, including 4,510 Ps cases and 212,242 controls, and 1,637 PsA cases and 212,242 controls. Even complementary MR methods were implemented, including an inverse variance weighting method, followed by a sensitivity analysis to verify the robustness of the results. Results: In this study, we found that certain bacterial taxa, such as Lactococcus, Ruminiclostridium 5, and Eubacterium fissicatena, were identified as risk factors. Conversely, Alloprevotella and Odoribacter demonstrated a protective effect against Ps. In the case of PsA, our results revealed a distinct set of risk factors and protective factors among the gut bacterial taxa. Lactococcus, Verrucomicrobiales, Akkermansia, Coprococcus 1, Lachnospiraceae, and Verrucomicrobiaceae were identified as risk factors for PsA. On the other hand, Odoribacter, Rikenellaceae, Clostridium innocuum, and Marvinbryantia exhibited a protective effect against the development of PsA. Conclusion: Our findings shed light on the distinctive disease characteristics and onset features between Ps and PsA. Notably, certain intestinal flora were implicated in the pathogenesis of PsA, suggesting their potential role as early diagnostic indicators. Furthermore, we identified several bacterial flora that exhibit a potential protective effect against the occurrence of Ps and PsA. These discoveries lay a solid foundation for future endeavors in the prevention and treatment of these conditions.

Preprint ARTICLE | doi:10.20944/preprints202306.1720.v1

Finite Element Analysis (FEA) of the Stress and Strain Distribution in Cone-Morse Implant-Abutment Connection Implants Placed in an Equicrestal and Subcrestal Position

Natalia Di Pietro, Mario Ceddia, Tea Romasco, Nilton De Bortoli Junior, Bruno Freitas Mello, Margherita Tumedei, Alessandro Specchiulli, Adriano Piattelli, Bartolomeo Trentadue

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Bacterial leakage; Cone-Morse connection; dental implants; equicrestal implant placement; Finite Element Analysis (FEA); implant-abutment junction; implant placement; subcrestal implant placement.

Online: 25 June 2023 (05:49:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1717.v1

Post-traumatic Stress and Depressive Sequelae in ICU Hospitalized COVID-19 Patients 6 Months after Discharge: A Comparison with Non-COVID ICU Patients

Claudia Carmassi, Silvia Pini, Maria Martelli, Sara Fantasia, Martina Calvaruso, Lucrezia Castellani, Virginia Pedrinelli, Carlo Antonio Bertelloni, Liliana Dell’Osso

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: post-traumatic stress disorder; trauma; depression; physical disabilities; intensive care unit; coronavirus disease 2019

Online: 25 June 2023 (05:15:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1704.v1

A Comparative Investigation of Chemical Decontamination Methods for In Situ Cleaning of Dental Implant Surfaces

Badra Hussain, Sadia Khan, Anne Eriksson Agger, Jan Eirik Ellingsen, Ståle Petter Lyngstadaas, Jaime Bueno, Håvard J Haugen

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: dental implant; acquired pellicle; peri-implant disease; chemical decontamination

Online: 25 June 2023 (03:23:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1697.v1

Potential of Human Hemoglobin as a Source of Bioactive Peptides: Comparative Study of Enzymatic Hydrolysis with Bovine Hemoglobin and Production of Active Peptide α137-141.

Ahlam Outman, Barbara Deracinois, Christophe Flahaut, Mira Abou Diab, Bernard Gressier, Bruno Eto, Naima Nedjar

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Bovine hemoglobin; Human hemoglobin; Bioactives peptides; Neokyotorphin

Online: 24 June 2023 (15:06:20 CEST)

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Cruor, the main component responsible for the red color of blood in mammals, contains 90% hemoglobin, a protein that is considered a rich source of bioactive peptides. The aim of the present study is to evaluate the potential of human hemoglobin as a source of bioactive peptides, compared to bovine hemoglobin, which has been widely studied in recent years. More specifically, the study focused on neokyotorphin, a natural antimicrobial peptide and meat preservative, which corresponds to the α137-141 fragment of bovine hemoglobin produced by enzymatic hydrolysis. Firstly, the results of the in-silico analysis showed that the two types of hemoglobin have a high similarity for the α and β chains (identities of 88% and 91%, respectively). Secondly, both types of hemoglobin were subjected to similar enzymatic hydrolysis conditions, which showed that the hydrolysis of human hemoglobin followed the same reaction mechanism as the hydrolysis of bovine hemoglobin, the 'Zipper' mechanism. The hydrolysis conditions (23°C, pH 3.5) made it possible to obtain α137-141 in significant quantities to allow for significant valorization from an industrial point of view. The hydrolyses were able to take place at high initial substrate concentrations, allowing for faster and more efficient processing of the co-product in the same amount of time, with over 65% of this production achieved in just 30 min. Increasing the substrate concentration (from 1% to 10% (w/v)) resulted in a proportional increase in α137-141 production. Regardless of the concentrations tested, the kinetic pattern remained similar. Finally, the results of the mass spectrometry analysis revealed the presence of several bioactive peptides in cattle and humans. Although some were known before, new bioactive peptides were discovered in human hemoglobin, such as four antibacterial peptides (α37-46 PTTKTYFPHF; α36-45 FPTTKTYFPH; α137-141 TSKYR; α133-141 STVLTSKYR), four opioid peptides (α137-141 TSKYR; β31-40 LVVYPWTQRF; β31-37 LVVYPWT), an ACE inhibitor (β129-135 KVVAGVA), an anticancer agent (β33-39 VVYPWTQ) and an antioxidant (α137-141 TSKYR). These peptides have never been found in human hemoglobin before, according to our knowledge. These results highlight the potential of human hemoglobin as a source of bioactive peptides useful for the food or pharmaceutical industry.

Preprint REVIEW | doi:10.20944/preprints202306.1696.v1

I feel! Therefore, I am. From Pain to Consciousness in DOC Patients.

Francesco Riganello, Paolo Tonin, Andrea Soddu

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Pain; Nociception; Disorders of Consciousness; Consciousness

Online: 23 June 2023 (15:38:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1687.v1

Exhaled Nitric Oxide and Pulmonary Oxygen Toxicity Susceptibility

David Mark Fothergill, Jeffrey W Gertner

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: hyperoxia; pulmonary function; expired nitric oxide; spirometry; oxygen toxicity; diving; hyperbaric

Online: 23 June 2023 (13:05:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0718.v3

3D Analysis of the Upper and Lower Arches Using Digital Technology: Measurement of the Index of Bolton and Correspondence between Arch Shape and Orthodontic Arches

Marco Pasini, Elisabetta Carli, Federico Giambastiani, Maria Rita Giuca, Domenico Tripodi

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: digital models; Bolton index; orthodontics CAD Software; extra-oral scanner

Online: 23 June 2023 (12:51:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1683.v1

Effects of Cerebrolysin Administration With Association With Additional Amantadine Treatment and Neuromonitoring on the Outcome in Patients With TBI Diagnosis - Results of an Observational Cohort Study

Konrad Jarosz, Klaudyna Kojder, Agata Andrzejewska, Joanna Solek-Pastuszka, Anna Jurczak

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: TBI; Cerebrolysin; Amantadine; neuromonitoring; NIRS; ONDS; ICP; SjO2

Online: 23 June 2023 (12:38:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1682.v1

An Amphipathic Cell-Penetrating Peptide-Aided Delivery of Cas9 RNP for Gene Editing and Correction

Mert Öktem, Olivier G. De Jong, Enrico Mastrobattista

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: CRISPR/Cas9; Cell-penetrating peptide (CPP); LAH5; RNP; HDR; delivery

Online: 23 June 2023 (12:31:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1675.v1

Validation of Lead-DBS β-oscillation Localization with Directional Electrodes

Colette Boëx, Abdullah Al Awadhi, Rémi Tyrand, Marco Vincenzo Corniola, Astrid Kibleur, Vanessa Fleury, Pierre R. Burkhard, Shahan Momjian

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Imaging toolbox; Local field potentials; Lead-DBS; subthalamic nucleus; Parkinson’s disease

Online: 23 June 2023 (12:02:12 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202306.1673.v1

Unintentional Two-Stage Surgery of Hypervascular Choroid Plexus Papilloma considering Venous Drainage: A Case Report

Daishiro Abe, Kohei Kanaya, Takafumi Kiuchi, Sumio Kobayashi, Kenji Sano, Tetsuyoshi Horiuchi

Subject: Medicine And Pharmacology, Surgery Keywords: choroid plexus papilloma; hypervascular tumor; surgical strategy; venous drainage

Online: 23 June 2023 (12:00:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1670.v1

Low and Ultra-low HER2 in Human Breast Cancer: An Effort to Define New Neoplastic Subtypes

Mariausilia Franchina, Cristina Pizzimenti, Vincenzo Fiorentino, Maurizio Martini, Giuseppina Rosaria Rita Ricciardi, Nicola Silvestris, Antonio Ieni, Giovanni Tuccari

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: HER2 expression; Breast cancer; Neoadjuvant treatment; HER2-low carcinomas; HER2 ultra-low carcinomas

Online: 23 June 2023 (11:55:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1654.v1

Serum Level of Cytokeratin 18 (M65) as Prognostic Marker of High Cardiovascular Disease Risk in Non-alcoholic Fatty Liver Disease Individuals

Sabrina Pagano, Stephan J.L. Bakker, Catherine Juillard, Robin P.F. Dullaart, Nicolas Vuilleumier

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Cytokeratin 18; Non-Alcoholic Fatty Liver Disease; Fatty liver index; Framingham risk score; Systematic COronary Risk Evaluation 2

Online: 23 June 2023 (10:36:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1647.v1

Clinical Applications of Polypodium leucotomos (Fernblock®): An Update

Azahara Rodríguez-Luna, Alicia Zamarrón, Ángeles Juarranz, Salvador González

Subject: Medicine And Pharmacology, Dermatology Keywords: Polypodium leucotomos; Fernblock®; photoprotection; photodermatoses; photoaging; hyperpigmentation

Online: 23 June 2023 (08:58:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1646.v1

Development and Validation of an Enzyme-Linked Immunosorbent Assay-Based Protocol for Evaluation of Respiratory Syncytial Virus Vaccines

Eliel Nham, A-Yeung Jang, Hyun Jung Ji, Ki Bum Ahn, Joon-Yong Bae, Man-Seong Park, Hakjun Hyun, Jin Gu Yoon, Hye Seong, Ji Yun Noh, Hee Jin Cheong, Woo Joo Kim, Ho Seong Seo, Joon Young Song

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: respiratory syncytial virus; RSV; ELISA; Vaccine; Immunogenicity

Online: 23 June 2023 (08:36:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1643.v1

Small Molecules against Metastatic Tumors: Concrete Perspectives and Shattered Dreams

Massimo Serra, Davide Rubes, Sergio Schinelli, Mayra Paolillo

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: metastasis treatment; small molecules; tyrosine kinase inhibitors; integrins; siRNA

Online: 22 June 2023 (16:10:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1640.v1

Predicting Risk of Malignant Stroke in MCA stroke after Successful Re-canalization Using (A-P) Score

Avirag Goswami, Naraharisetty Anita Rau, Jonathan Dissin, Patricia Hushen

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: ASPECTS: Alberta Stroke Program Early CT Score; NIHSS: National Institutes of Health Stroke Scale; TICI: Thrombolysis in cerebral infarction; MCA: Middle Cerebral Artery; CBF: Cerebral Blood Flow; ICP: Intracerebral Pressure; CPP: Cerebral Perfusion Pressure; ADAPT: A Direct Aspiration First Pass Technique

Online: 22 June 2023 (15:24:50 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202306.1639.v1

Controlled Case Report on the Surgical Treatment of Recurrent Rectal Cancer. The Role of the Minimally Invasive Approach

Paolo Izzo, Luciano Izzo, Maurizio Cardi, Andrea Polistena, Daniele Crocetti, Simone Sibio, Claudia De Intinis, Sara Izzo

Subject: Medicine And Pharmacology, Surgery Keywords: colorectal cancer; laparoscopic surgery; robotic surgery; open-air surgery

Online: 22 June 2023 (15:14:42 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202306.1637.v1

Rapidly Growing Ulcerated Breast Cancer in a 46-year-old Female Patient

Paolo Izzo, Luciano Izzo, Fabrizio Ceci, Silvia Lai, Andrea Polistena, Simone Sibio, Massimo Codacci-Pisanelli, Daniele Crocetti, Raimondo Gabriele, Claudia De Intinis, Sara Izzo

Subject: Medicine And Pharmacology, Surgery Keywords: rapidly growing ulcerated breast cancer; intensive neoadjuvant chemotherapy; skin ulceration; invasive ductal carcinoma; doxorubicin; cyclophosphamide.

Online: 22 June 2023 (15:00:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1636.v1

Clinical Decision Support Systems for brain tumour diagnosis and prognosis: a systematic review

Teesta Mukherjee, Omid Pournik, Sarah N. Lim Choi Keung, Theodoros N. Arvanitis

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: clinical decision support system; brain tumour; brain neoplasms; diagnosis; prognosis; systematic review

Online: 22 June 2023 (14:59:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1635.v1

Surface Roughness of Enamel and Dentin after Preparation Finishing with Rotary Burs or Piezoelectric Instruments

Antonio Rapani, Federico Berton, Amedeo Tramontin, Gianluca Turco, Giulio Marchesi, Roberto Di Lenarda, Claudio Stacchi

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: finishing line; margin preparation; piezosurgery; surface roughness.

Online: 22 June 2023 (14:52:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1633.v1

Neurotrophin Analog ENT-A044 Activates the p75 Neurotrophin Receptor Promoting Cell Death in Mouse and Human Neuronal Cells

M. A. Papadopoulou, T. Rogdakis, D. Charou, M. Peteinareli, K. Ntarntani, A. Gravanis, K. Chanoumidou, I. Charalampopoulos

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: neurotrophins; p75 receptor; steroidal synthetic analogs; TrkB receptor; cell death; neural stem cells; human induced pluripotent stem cells

Online: 22 June 2023 (13:00:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1626.v1

Antimicrobial Agent Against Methicillin-Resistant Staphylococcus Aureus Biofilm Monitored using Raman Spectroscopy

Young-Won Chin, Jina Kim

Subject: Medicine And Pharmacology, Pharmacy Keywords: Methicillin-resistant Staphylococcus aureus; biofilm; Antimicrobial agent; eugenol; Raman spectroscopy.

Online: 22 June 2023 (12:40:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1623.v1

The Usefulness of Thyroid Antibodies in the Diagnostic Approach to Autoimmune Thyroid Disease

Hernando Vargas-Uricoechea, Juan Patricio Nogueira, María V. Pinzón-Fernández, Diego Schwarzstein

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Thyroid; autoimmunity; antibodies; thyrotropin; receptor; thyroglobulin; peroxidase

Online: 22 June 2023 (12:25:56 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202306.1615.v1

Fence Technique: Reconstruction on the Asthenic Zone After Cyst Enucleation - Case Report

Francisco Correia, André de Brum Marques, Célia Rodrigues, Ricardo Faria-Almeida

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Cysts; Bone Regeneration; Dental Implants; Case Reports [Publication Type]

Online: 22 June 2023 (12:06:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1603.v1

Single Cell Transcriptomic Analysis in a Mouse Model of Barth Syndrome Reveals Cell-Specific Alterations in Gene Expression and Intercellular Communication

Gayani Perera, Liam Power, Amy Larson, Christina J. Codden, Junya Awata, Rebecca Batorsky, Douglas Strathdee, Michael T. Chin

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Tafazzin; Barth Syndrome; Single-Nucleus RNA-sequencing; Cardiomyopathy; Mitochondria; Gene Expression; Metabolism

Online: 22 June 2023 (11:31:02 CEST)

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Barth Syndrome, a rare X-linked disorder affecting 1:300,000 live births, results from defects in Tafazzin, an acyltransferase that remodels cardiolipin and is essential for mitochondrial respiration. Barth Syndrome patients develop cardiomyopathy, muscular hypotonia and cyclic neutropenia during childhood, rarely surviving to middle age. At present, no effective therapy exists and downstream transcriptional effects of Tafazzin dysfunction are incompletely understood. To identify novel, cell-specific, pathological pathways that mediate heart dysfunction, we performed single-nucleus RNA-sequencing (snRNA-seq) on wild-type (WT) and Tafazzin-knockout (Taz-KO) mouse hearts. We determined differentially expressed genes (DEGs) and inferred predicted cell-cell communication networks from these data. Surprisingly, DEGs were distributed heterogeneously across the cell types, with fibroblasts, cardiomyocytes, endothelial cells, macrophages, adipocytes and pericytes exhibiting the greatest number of DEGs between genotypes. One differentially expressed gene was detected for the lymphatic endothelial and mesothelial cell types, while no significant DEGs were found in the lymphocytes. A Gene Ontology (GO) analysis of these DEGs showed cell-specific effects on biological processes such as fatty acid metabolism in adipocytes and cardiomyocytes, increased translation in cardiomyocytes, endothelial cells and fibroblasts, in addition to other cell-specific processes. Analysis of ligand-receptor pair expression, to infer intercellular communication patterns, revealed the strongest dysregulated communication involved adipocytes and cardiomyocytes. For the knockout hearts, there was a strong loss of ligand-receptor pair expression involving adipocytes, and cardiomyocyte expression of ligand-receptor pairs underwent reorganization. These findings suggest that adipocyte and cardiomyocyte mitochondria may be most sensitive to mitochondrial Tafazzin deficiency and that rescuing adipocyte mitochondrial dysfunction, in addition to cardiomyocyte mitochondrial dysfunction, may provide therapeutic benefit in Barth Syndrome patients.

Preprint ARTICLE | doi:10.20944/preprints202306.1601.v1

Bimanual Movement Characteristics and Real-World Performance Following Hand Arm Bimanual Intensive Therapy in Children with Unilateral Cerebral Palsy

Shailesh S. Gardas, Christine Lysaght, Amy Gross McMillan, Shailesh Kantak, John Willson, Charity Galena Patterson, Swati M. Surkar

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Training intensity; bimanual coordination; real-world activity; actigraphs; upper extremity

Online: 22 June 2023 (11:22:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0725.v3

The Effect of Dissociation on the Binocular Visual Response in Children

Danjela Ibrahimi, Marcos Aviles, Juvenal Rodríguez-Reséndiz

Subject: Medicine And Pharmacology, Ophthalmology Keywords: visual function; Howell test; alternate Cover test; Thorington test; dissociated phoria state; break value of near point of convergence; degree of stereopsis

Online: 22 June 2023 (10:43:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1578.v1

Gut Microbiome and Diabetes – A Bibliometric and Narrative Review

Ashutosh Mishra, Pallavi Mishra, Vinaytosh Mishra

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Gut Microbiota; Dysbiosis; Endocrine; Diabetes; Therapeutic

Online: 21 June 2023 (16:02:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1574.v1

Cost-Utility of Monulpiravir in COVID-19 Treatment: An Estimation in Vietnam Situation

Nam Xuan Vo, Ngan Nguyen Hoang Le, Trinh Dang Phuong Chu, Huong Lai Pham, Khang Xuan An Dinh, Tu Kim Tran, Tien Thuy Bui

Subject: Medicine And Pharmacology, Pharmacy Keywords: Cost-utility; Covid-19; Molnupiravir; Vietnam; Utility

Online: 21 June 2023 (15:34:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1565.v1

Review of Classification Systems for AAFD/PCFD and the Triple Classification Delinking Instability/Deformity and Foot Type

Chandra Seker Pasapula, Makhib Rasid Choudkhuri, Eva Gil Monzó, Vivek Dhukaram, Sajid Shariff, Vitālijs Pasterse, Douglas Richie, Tamas Kobezda, Georgios Solomou, Steven Cutts

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Forefoot deformities; flatfoot syndrome

Online: 21 June 2023 (14:26:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1560.v1

Associations Between Menopausal Hormone Therapy and Colorectal, Lung or Melanoma Cancer Recurrence and Mortality: A Systematic Reviews and Meta-Analysis

Gabriel Fiol Ruiz, Luis Ignacio Lete Lasa, Laura Nieto, Ana Santaballa, María Jesús Pla, Laura Baquedano, Joaquim Calaf, Pluvio Coronado, Esther De la Viuda, Placido Llaneza, Borja Otero, Sonia Sánchez-Mendez, Isabel Ramirez, Nicolás Mendoza

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: cancer survival; hormonal menopausal treatment

Online: 21 June 2023 (13:28:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1558.v1

Olive Oil Phenolic Compounds Activity Against Age-Associated Cognitive Decline: Clinical and Experimental Evidence

Anna Boronat, Gabriele Serreli, Jose Rodríguez-Morató, Monica Deiana, Rafael De la Torre

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: olive oil; extra virgin olive oil; phenolic bioactive compounds; cognitive decline; hydroxytyrosol; tyrosol; cognitive performance; neuroprotection

Online: 21 June 2023 (13:17:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1557.v1

Chronic Granulomatous Disease (CGD): Pathogens and Management

Angel A. Justiz-Vaillant, Arlene Faye-Ann Williams-Persad, Rodolfo Arozarena-Fundora, Patrick Eberechi Akpaka, Darren Gopaul

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Chronic granulomatous disease; Microorganisms; Neutrophils; Antimicrobials

Online: 21 June 2023 (13:10:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1555.v1

Contribution of Arab Countries to Oncology Clinical Trials: A Bibliometric Analysis

Humaid O. Al-Shamsi, Ibrahim Abu-Gheida, Kareem Sameh, Nourane E. Tahoun, Khaled M. Musallam

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: research; oncology; Arab; Middle East; North Africa; cancer management

Online: 21 June 2023 (12:53:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1554.v1

Lymphatic System – Surgeon’s Point of View

Alexandre Almeida, Hagit Ofir, Assaf A Zeltzer

Subject: Medicine And Pharmacology, Surgery Keywords: Lymphedema; Preoperative assessment; Surgical treatment; Liposuction; Direct excision; LVA; VLNT

Online: 21 June 2023 (12:52:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1548.v1

A One-step Sample Processing Method in Combination With Hplc-Ms/Ms for the Simultaneous Quantification of Atorvastatin, Ezetimibe and Three Metabolites Including O-Hydroxyl Atorvastatin, P-Hydroxyl Atorvastatin, and Ezetimibe-Glucuronide in Human Plasma

T.Nguyen Nguyen Le, Nai Ngoc Chuong, Tuan Duc Nguyen

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: atorvastatin; ezetimibe; o-hydroxyl atorvastatin; p-hydroxyl atorvastatin; ezetimibe-glucuronide; LC-MS/MS; SALLE; human plasma

Online: 21 June 2023 (12:06:30 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202306.1547.v1

The Multifaceted Syndromic Primary Immunodeficiencies in Children

Khuen Foong Ng, Anu Goenka, Florence Manyika, Jolanta Bernatoniene

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Primary immunodeficiency disorder; genetic syndromes; syndromic children; multisystem disorder; inborn errors of immunity

Online: 21 June 2023 (11:57:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1545.v1

Soft Tissue Sarcoma Mimicking Melanoma: A Systematic Review

Fortunato Cassalia, Francesco Cavallin, Andrea Danese, Paolo Del Fiore, Claudia Di Prata, Marco Rastrelli, Anna Belloni Fortina, Simone Mocellin

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Melanoma; Sarcoma; Mimicking.

Online: 21 June 2023 (11:51:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1535.v1

Interleukins Polymorphisms In Type-1 Diabetes And Perio-dontitis: A Review

Silvia D’Agostino, Giulia Valentini, Francesca Iarussi, Marco Dolci

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: type 1 diabetes; polymorphisms; interleukins; periodontitis; systemic inflammation; peripheral inflammation; childhood

Online: 21 June 2023 (11:01:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1531.v1

N-acetylcysteine Amide AD4 and Thioredoxin Mimetic Peptides Inhibit Platelet Aggregation and Protect from Oxidative Stress

Sonia Eligini, Marco Munno, Daphne Atlas, Cristina Banfi

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: platelet; aggregation; N-acetylcysteine; N-acetylcysteine amide; thioredoxin mimetic peptides; clotting time; TxB2; 12-HETE

Online: 21 June 2023 (10:56:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1524.v1

Biological and Clinical Significance of TIMPs Expression in Breast Cancer: a Bioinformatic Analysis

Lorena Cayetano-Salazar, Adán Arizmendi-Izazaga, Dania A. Nava-Tapia, Eymard Hernández-López, Caroline Weinstein-Oppenheimer, Julio Ortiz-Ortiz, Marco A. Leyva-Vázquez, Miguel A. Mendoza-Catalán, Napoleón Navarro-Tito

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: breast cancer; TIMPs; tumor progression

Online: 21 June 2023 (10:16:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1516.v1

Ultrasonographic Evaluation of Gastric Content and Volume in Elective Pediatric Patients: A Prospective Observational Study

Asiye Demirel, Şeyda Efsun Özgünay, Şermin Eminoğlu, Ayşe Neslihan Balkaya, Tuğba Onur, Nermin Kılıçarslan, Mehmet Gamlı

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Pulmonary aspiration; gastric ultrasound; antrum; gastric volume; elective surgery

Online: 21 June 2023 (09:54:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1487.v1

Circular and Circulating DNA in IBD: from Pathogenesis to Potential Molecular Therapies

Federica Di Vincenzo, Ylenia Yadid, Valentina Petito, Valeria Emoli, Letizia Masi, Daniela Gerovska, Marcos Jesus Araúzo-Bravo, Antonio Gasbarrini, Birgitte Regenberg, Franco Scaldaferri

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: cell-free nucleic acids; cell-free DNA; circular DNA; microvescicles; inflammatory bowel disease; cGAS-STING; TLR9; oligonucleotides; bioinformatics; molecular therapies.

Online: 21 June 2023 (08:55:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1479.v1

Interplay of Serum Leptin, Tumor Necrosis Factor Alpha, and Testosterone in Overweight-Related Hypertensive Men

Shalan Alaamri, Abdulhalim S Serafi, Zahir Hussain, Shouq K. Bafail, Mohammed A. Bafail, Lusine H. Demirkhanyan, Christopher S Gondi, Sumera Sohail

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Hypertension; overweight-related hypertension; serum leptin; TNF-α, testosterone; total cholesterol; IL-6

Online: 21 June 2023 (08:43:46 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202306.1508.v1

A Screening Proposal for Zoom Dysmorphia in Virtual Settings

Cemre Büşra Türk, Fatima Mirza, George Kroumpouzos

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: zoom dysmorphia; body dysmorphic disorder; screening; scale; questionnaire; telehealth; body image

Online: 21 June 2023 (08:41:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1503.v1

Characteristics of Preoperative Arteriosclerosis Evaluated by Cardio-Ankle Vascular Index in Patients With Osteoarthritis Before Total Knee Arthroplasty

Yoshinori Ishii, HIdeo Noguchi, Junko Sato, Ikuko Takahashi, Hana Ishii, Ryo Ishii, Kei Ishii, Kai Ishii, Shin-ichi Toyabe

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: osteoarthritis; arteriosclerosis; cardio-ankle vascular index; total knee arthroplasty; age; body mass index

Online: 21 June 2023 (08:28:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1494.v1

Microgravity-Induced Changes to Drug Response in Cancer Cells Quantified Using Fluorescence Morphometry

Spencer McKinley, Adam Taylor, Conner Peeples, Megha Jacob, Gargee Khaparde, Yohan Walter, Andrew Ekpenyong

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: microgravity; chemotherapy; paclitaxel; hydroxyurea; morphometry; drug response; immune dysfunction; space medicine; terrestrial medicine; fluorescence microscopy

Online: 21 June 2023 (07:34:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1493.v1

Differences Between Hepatic and Cerebral Regional Tissue Oxygen Saturation at the Onset of Intradialytic Hypotension

Shohei Kaneko, Susumu Ookawara, Kiyonori Ito, Saori Minato, Yuko Mutsuyoshi, Yuichiro Ueda, Keiji Hirai, Yoshiyuki Morishita

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: cerebral oxygenation; hepatic oxygenation; intradialytic hypotension; splanchnic circulation; ultrafiltration rate

Online: 21 June 2023 (07:33:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1491.v1

Significance of Lipopolysaccharides in Gastric Cancer and their Potential as a Biomarker for Nivolumab Sensitivity

Nobuhiro Nakazawa, Takehiko Yokobori, Makoto Sohda, Nobuhiro Hosoi, Takayoshi Watanabe, Yuki Shimoda, Munenori Ide, Akihiko Sano, Makoto Sakai, Bilguun Erkhem-Ochir, Hiroomi Ogawa, Ken Shirabe, Hiroshi Saeki

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: epithelial–mesenchymal transition (EMT); Gastric cancer; lipopolysaccharides (LPS); Nivolumab; TGF-β

Online: 21 June 2023 (07:28:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1477.v1

Cefto-Reallife Study: Real World Data on the Use of Ceftobiprole in a Multicenter Spanish Cohort

Carmen Hidalgo-Tenorio, Ines Pitto Robles, Daniel Arnes Garcia, F Javier Membrill De Novales, Laura Morata, Rosario Menendez, Olga Bravo De Pablo, Vicente Abril Lopez de Medran, Miguel Salavert Lleti, Pilar Vizcarra, Jaime Lora Tamayo, Ana Arnaiz Garcia, Leonor Moreno Nuñez, Mar Masia, Maria pilar Ruiz Seco, Svetlana Sadyrbaeva Dolgova

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Ceftobiprole; sepsis; older; Real-World Data; OPAT

Online: 21 June 2023 (04:10:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1476.v1

Microtubule Dynamics Deregulation Induces Apoptosis in Human Urothelial Bladder Cancer Cells via a p53-independent Pathway

Yiannis Drosos, Eumorphia G. Konstantakou, Aggeliki-Stefania Bassogianni, Konstantinos-Stylianos Nikolakopoulos, Dimitra G. Koumoundourou, Sophia P. Markaki, Ourania E. Tsitsilonis, Gerassimos E. Voutsinas, Dimitrios Valakos, Ema Anastasiadou, Dimitris Thanos, Athanassios D. Velentzas, Dimitrios J. Stravopodis

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Apoptosis; Bladder; Cancer; Microtubule; p53; Paclitaxel; Urothelium

Online: 21 June 2023 (03:50:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1420.v1

The Potential Role of Histone Modifications in Glioblastoma Therapy: Review Article.

Mohammed A. Azab

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: glioma; histone; HDAC; therapy

Online: 21 June 2023 (03:13:00 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202306.1411.v1

Weight-Bias Internalization and Eating-Disorder Psycho-Pathology in Treatment-Seeking Patients With Obesity

Simona Calugi, Barbara Segattini, Gianmatteo Cattaneo, Mirko Chimini, Anna Dalle Grave, Laura Dametti, Manuela Molgora, Riccardo Dalle Grave

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: obesity; weight bias; body image; body dissatisfaction; exposure avoidance; shape dissatisfac-tion; empty stomach

Online: 21 June 2023 (03:10:22 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202306.1418.v1

Styletubation in Bariatric Surgery

Bor-Gang Wu, Hsiang-Ning Luk, Jason Zhensheng Qu, Alan Shikani

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Styletubation; video-assisted intubating stylet; obesity; super-super obesity; bariatric surgery; laparoscopic sleeve gastrectomy; tracheal intubation; laryngoscopy; videolaryngoscope; anesthesia; difficult airway

Online: 21 June 2023 (02:17:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1457.v1

Cerebrovascular Disease in COVID-19

James E. Siegler, Savanna Dasgupta, Mohamad Abdalkader, Mary Penckofer, Shadi Yaghi, Thanh N. Nguyen

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Coronavirus disease 2019; COVID-19; Stroke; Cerebral vein thrombosis; Intracranial hemorrhage; Anticoagulation; Mechanical thrombectomy; Intravenous thrombolysis

Online: 20 June 2023 (15:13:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1455.v1

Nebulized recombinant tissue plasminogen activator (rt-PA) for acute COVID-19-induced severe respiratory failure: an exploratory proof of concept trial

Pratima Chowdary, Banwari Agarwal, Maria Rita Peralta, Sanjay Bhagani, Simon Lee, James Goldring, Marc Lipman, Emal Waqif, Mark Phillips, Helen Philippou, Jonathan H Foley, Nicola J Mutch, Robert Ariens, Kathleen A Stringer, Federico Ricciardi, Marie Watissée, Derralynn Hughes, Amit Nathwani, Anne Riddell, David Patch, Jim Buckley, Mark De Neef, Rahul Dimber, Cecilia Diaz-Garcia, Honey Patel, Aarti Nandani, Upuli Dissanayake, Nick Chadwick, Ahmed Alkhatip, Peter Watkinson, Eamon Raith, Suveer Singh, Tony Wolff, Rajeev Jha, Simon E Brill, Ameet Bakhai, Alison Evans, Farhat Gilani, Keith Gomez

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Acute respiratory illness; critical care; recombinant tissue plasminogen activator; nebulization, fibrinolytics, COVID-19 pandemic, inhaled medication, targeted therapy

Online: 20 June 2023 (14:59:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1454.v1

Effects of Vasopressin Receptor Agonists During the Resuscitation of Hemorrhagic Shock: A Systematic Review and Meta-Analysis of Preclinical and Clinical Studies

Eleni Laou, Nikolaos Papagiannakis, Androniki Papadopoulou, Theodora Choratta, Minas Sakellakis, Mariachiara Ippolito, Ioannis Pantazopoulos, Andrea Cortegiani, Athanasios Chalkias

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: vasopressin; vasopressin receptor agonist; hemorrhagic shock; resuscitation; hemodynamics; outcome

Online: 20 June 2023 (14:57:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1450.v1

Oleocanthal Ameliorates Metabolic and Behavior Phenotypes in a Mouse Model of Alzheimer’s Disease

Euitaek Yang, Junwei Wang, Lauren N. Woodie, Michael W. Greene, Amal Kaddoumi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’s disease; blood-brain barrier; metabolic phenotype; sleep behavior; Promethion cages; oleocanthal

Online: 20 June 2023 (14:31:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1446.v1

Parallelogram Excision: A New Rung on the Reconstructive Ladder for High-Tension Skin Areas

Francesco Costa, Filippo Boriani, Syed Haroon Ali Shah, Jeyaram Srinivasan

Subject: Medicine And Pharmacology, Surgery Keywords: Skin excision; plastic surgery; parallelogram excision; sarcoma; orthopaedics

Online: 20 June 2023 (14:01:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1442.v1

What about Alkaline Phosphatase in Endocarditis?

Amila Kahrovic, Thomas Poschner, Anna Schober, Philipp Angleitner, Leila Alajbegovic, Martin Andreas, Doris Hutschala, Ruud Brands, Günther Laufer, Dominik Wiedemann

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: alkaline phosphatase; cardiac surgery; cardio-pulmonary bypass; endocarditis; kidney

Online: 20 June 2023 (12:35:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1440.v1

Ratio of Extracellular to Intracellular Water is Associated with Permanent Catheter Patency Survival in Patients Receiving Maintenance Hemodialysis

Moo Jun Kim, Jae-Wan Jeon, Hae-Ri Kim, Hyerim Park, Suyeon Han, Yunkyeong Hwang, Heewon Park, Kyungho Park, Eu-Jin Lee, Young-rok Ham, Ki Ryang Na, Kang-Wook Lee, Dae Eun Choi

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: body composition monitoring; extracellular water; intracellular water; hemodialysis; permanent catheter; catheter patency; infection; malfunction

Online: 20 June 2023 (12:20:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1426.v1

Inhibitors of Farnesyl Diphosphate Synthase and Squalene Synthase: Potential Source for Anti-Trypanosomatidae Drug Discovery

Boniface Pone Kamdem, Fabrice Fekam Boyom

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Trypanosomatids; squalene synthase; farnesyl diphosphate synthase; target-based approach; neglected tropical diseases.

Online: 20 June 2023 (10:27:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1421.v1

Node Oligo-Recurrence in Prostate Cancer: A Challenge

Almudena Zapatero, Antonio Jose Conde Moreno, Marta Barrado Los Arcos, Diego Aldave

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Oligometastases; prostate cancer; PSMA-PET; stereotaxic body radiotherapy (SBRT); oligorecurrent prostate cancer; metastasis directed therapy; clinical trials.

Online: 20 June 2023 (09:56:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1417.v1

Clinical and Epidemiological Risk Factors Associated with Hospitalization and Mortality Rate of COVID-19 Patients in Banja Luka County: Retrospective Observational Cohort Study on 40,000 patients

Nataša Pilipović-Broćeta, Nevena Todorović, Ranko Škrbić, Jela Aćimović, Savka Štrbac, Ivan Soldatović

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: COVID-19; risk factors; hospitalization; mortality; Bosnia and Herzegovina

Online: 20 June 2023 (09:38:40 CEST)

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Background and Objectives: Since the beginning of COVID-19 pandemic, the infection primarily affected patients with following chronic conditions: cardiovascular disease, hypertension, chronic obstructive pulmonary disease, diabetes mellitus, obesity and cancer. The aim of this study was to explore clinical and epidemiological characteristics associated with COVID-19 outcomes in patients at the primary health care centre from March 2020 to September 2022. Materials and Methods: The study included 40,692 citizens of Banja Luka County, Bosnia and Herzegovina, who were confirmed and registered as RT-PCR positive on COVID-19. Differences regarding the distributions of patients between groups were analysed using Pearson chi square test and Mantel-Haenszel chi square test for trends, while differences in mean values were compared using independent samples t test. Relationship between mortality and independent variables were examined using logistic regression. Results: Out of 40,692 COVID-19 positive patients, 7.76% were hospitalized. The average age of hospitalized patients was significantly higher than the age of non-hospitalized patients (64.2±16.1 vs. 45.4±18.7; p<0.001). The average age of patients with lethal outcome was nearly twice higher compared to patients with non-lethal outcome (74.6±11.5 vs. 45.7±18.6; p<0.001). Male patients had higher hospitalization and mortality rate, compared to females (9.8% vs. 5.9%, p<0.001; 4.8% vs. 3%, p<0.001, respectively). The highest hospitalization rate was in patients with chronic renal failure, diabetes and cardiovascular diseases, while the death rate was the highest among patients with CRF and hearth comorbidities. Fever, cough, fatigue, nausea and vomiting, chest pain, shortness of breath and appetite loss favoured hospitalization. Patients with fatigue and appetite loss had higher percentage of lethal outcome. Vaccinated patients had significantly lower rate of lethal outcome. Conclusions: Clinical symptoms, signs and outcomes, are posing as predictive parameters for further management of COVID-19. Vaccination has an important role in clinical outcomes of COVID-19.

Preprint BRIEF REPORT | doi:10.20944/preprints202306.1409.v1

Transcutaneous Spinal Cord Stimulation Facilitates Respiratory Functional Performance in Patients with Post-acute COVID-19

Alexander Ovechkin, Tatiana Moshonkina, Natalia Shandybina, Vsevolod Lyakhovetskii, Ruslan Gorodnichev, Sergey Moiseev, Ricardo Siu, Yury Gerasimenko

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Neuromodulation; Spinal cord stimulation; Respiration; Rehabilitation; COVID-19

Online: 20 June 2023 (08:30:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1406.v1

Progress in circRNA-Based Therapy in Experimental Parkinson’s Disease

Simoneide Souza Souza Titze-de-Almeida, Ricardo Titze-de-Almeida

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: circRNA; Parkinson's disease; RNAi; neurodegenerative disease; oligonucleo-tide-based therapies

Online: 20 June 2023 (08:27:50 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202306.1403.v1

Acute Myocardial Infarction Due to Left Main Spontaneous Coronary Artery Dissection Complicated by Cardiogenic Shock in a 36 Weeks Pregnant Woman: Which Comes First?

Paolo Izzo, Luciano Izzo, Paolo Meloni, Manfredi Arioti, Terenzia Simari, Federico Sanchez, Cristian Cascione, Andrea Montevecchi, Chiara Boccherini, Fausta Orsi, Claudia De Intinis, Sara Izzo

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: acute myocardial infarction in pregnancy (pAMI), cardiogenic shock; coronary artery dissection; STEMI; percutaneous coronary intervention (PCI)

Online: 20 June 2023 (08:11:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1384.v1

Inorganic Compounds Used in Cancer Treatment

Ioana Babarus, Ionut-Iulian Lungu, Denisa Florina Diaconu, Alina Stefanache

Subject: Medicine And Pharmacology, Pharmacy Keywords: cancer; cisplatin; selenium; zinc

Online: 20 June 2023 (04:26:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0046.v2

Post-decompression Disc Herniation in Minimally Invasive versus "Mini-open" Technique - A More Common Complication

Ofir Uri, Liad Alfandari, Yoram Folman, Amit Keren, William Smith, Inbar Paz, Eyal Behrbalk

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Lumbar spinal stenosis; Spinal decompression; Minimally invasive surgery; Mini-open; Disc herniation; Post-decompression; Instability

Online: 19 June 2023 (15:17:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1374.v1

Clinicopathological Features and Prognosis of Resected Pancreatic Ductal Adenocarcinoma Patients with Claudin-18 Overexpression

Se Jun Park, Kabsoo Shin, In-Ho Kim, Tae Ho Hong, MyungAh Lee, Younghoon Kim, Ja Hee Suh

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: pancreatic cancer; claudins; zolbetuximab; prognosis

Online: 19 June 2023 (15:00:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1369.v1

Micronutrients in Pregnancy After Bariatric Surgery: A Narrative Review

Irene Bretón, Maria D. Ballesteros-Pomar, Alfonso Calle-Pascual, Luis Antonio Alvarez-Sala, Miguel Angel Rubio-Herrera

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: bariatric; pregnancy; micronutrient deficiency

Online: 19 June 2023 (14:19:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1359.v1

Acute changes on atrial function during progressive exercise in patients with heart failure with mildly-reduced ejection fraction. A case-control study

Ferdinando Iellamo, Giuseppe Caminiti, Marco Alfonso Perrone, Valentino D'Antoni, Alessandro Gismondi, Deborah Di Biasio, Sara Vadala, Giuseppe Marazzi, Valentina Morsella, Maurizio Volterrani

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: left atrial function, heart failure; stepwise exercise

Online: 19 June 2023 (12:59:37 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202306.1358.v1

Plasma Cell-free RNA PD-L1 Compared to Tissue PD-L1 Protein Expression and Outcomes with First-line Immunotherapy in Metastatic Non-small Cell Lung Cancer

Paul R. Walker, Sriraksha Jayananda, Melisa Pasli, Mahvish Muzaffar

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Liquid biopsy; PD-L1; plasma cfRNA; immunotherapy; NSCLC

Online: 19 June 2023 (12:57:52 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202306.1357.v1

mTOR Inhibition via Low-dose, Pulsed Rapamycin with Intraovarian Condensed Platelet Cytokines: An Individualized Protocol to Recover Diminished Reserve

E. Scott Sills, Conor Harrity, Samuel H. Wood, Seang Lin Tan

Subject: Medicine And Pharmacology, Reproductive Medicine Keywords: mTOR; rapamycin; PRP; platelet cytokines; ovarian reserve; IVF

Online: 19 June 2023 (12:55:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1351.v1

KV Channel-Interacting Proteins in Neurological and Cardiovascular System: An Updated Review

Leyi Wu, Yujuan Song, Cheng-Lin Zhang, Jie Liu

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: KV channel; KV channel-interacting proteins; neurodegenerative disorders; cardiovascular diseases

Online: 19 June 2023 (11:46:08 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1328.v1

Systemic Neoadjuvant and Adjuvant Therapies in the Management of Hepatocellular Carcinoma – A Narrative Review

Shadi Chamseddine, Michael LaPelusa, Ahmed Omar Kaseb

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Hepatocellular Carcinoma; neoadjuvant; adjuvant; perioperative; systemic therapy; immunotherapy

Online: 19 June 2023 (10:59:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1321.v1

Updates and Expert Opinion in Liver Transplantation for Gastrointestinal Malignancies

Alexander H. Shannon, Samantha M. Ruff, Austin D. Schenk, W. Kenneth Washburn, Timothy M. Pawlik

Subject: Medicine And Pharmacology, Transplantation Keywords: Transplant Oncology; Liver Transplant; Gastrointestinal Malignancies

Online: 19 June 2023 (08:33:55 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1306.v1

Exploring Therapeutic Applications of Autophagy in Spike Protein-Related Pathology

Matthew Halma, Paul Marik, Yusuf Saleeby

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Fasting; autophagy; long-COVID; post-vaccination syndrome; spike protein; mitochondria; mitophagy

Online: 19 June 2023 (07:39:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1312.v1

Treatment Strategies for High-Risk Prostate Cancer - Utility of Combination Therapy of Neoadjuvant Therapy and Radical Prostatectomy to Improve Oncologic Outcomes

Keita Nakane, Makoto Kawase, Koji Iinuma, Yuki Tobisawa, Manabu Takai, Daiki Kato, Kota Kawase, Shinichi Takeuchi, Naotaka Kumada, Sanae Namiki, Fumiya Sugino, Takayasu Ito, Takuya Koie

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: prostate cancer; high-risk prostate cancer; radical prostatectomy; radiation therapy; neoadjuvant therapy; oncological outcomes

Online: 19 June 2023 (07:21:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1297.v1

Zanubrutinib Ameliorates Cardiac Fibrosis and Inflammation Induced by Chronic Sympathetic Activation

Wenqi Li, Shuwen Zhu, Jing Liu, Zhigang Liu, Yang Miao, Jianwei Zhang, Shimeng Li, Qianyi Zhang, Zhichao Liu, Yue Yang, Li Chen, Xiaowei Guo, Tiantian Zhang, Lingxin Meng, Dan Chai, Guodong Tang, Xiaohe Li, Honggang Zhou, Cheng Yang

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Heart failure; β-adrenergic receptor; cardiac fibrosis; cardiac inflammation; Bruton’s tyrosine kinase; Zanubrutinib

Online: 19 June 2023 (05:23:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1290.v1

The Genetic Susceptibility to Psoriasis and the Relationship of Linked Genes to our Treatment Options

Heli A. Patel, Rishab Revankar, Sofia T. Pedroza, Shaveonte Graham, Steven R. Feldman

Subject: Medicine And Pharmacology, Dermatology Keywords: psoriasis; genetics; biologics; cytokines; interleukins; small molecules; JAK-STAT

Online: 19 June 2023 (04:59:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1284.v1

Clinical Insights in Cyclic Vomiting Syndrome Based on Genetic Findings

Richard G. Boles, Omri Bar, Elizabeth Vahey, Laurie Ebenau, Mark Mintz

Subject: Medicine And Pharmacology, Other Keywords: case reports; clinical management; CVS; disease mechanisms; DNA sequencing; gene expression; genetic testing; genetics; personalized medicine; vagal afferents

Online: 19 June 2023 (04:22:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1282.v1

Interventional Radiology for High-Flow Aneurysm of the Pancreaticoduodenal Arcades with Median Arcuate Ligament Syndrome: Review of 14 Patients

Valentin Siauve, Olivier Chevallier, Amin Mazit, Nicolas Falvo, Pierre-Olivier Comby, Romaric Loffroy

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Celiac trunk. High-flow aneurysm. Interventional radiology. Median arcuate ligament. Pancreaticoduodenal artery. Transcatheter arterial embolization.

Online: 19 June 2023 (04:13:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1279.v1

Medical Radiology in Italy: Current Progress

Alessia Pepe, Filippo Crimì, Federica Vernuccio, Giulio Cabrelle, Amalia Lupi, Chiara Zanon, Sebastiano Gambato, Anna Perazzolo, Emilio Quaia

Subject: Medicine And Pharmacology, Other Keywords: Cardiovascular Imaging; Rectal Imaging; Liver Imaging; Computed Tomography; Magnetic Resonance Imaging; Ultrasound

Online: 19 June 2023 (04:05:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1277.v1

Phytocompounds from Amazonian Plant Species against Acute Kidney Injury: Potential Nephroprotective Effects

Alberto Souza Paes, Rosemary de Carvalho Rocha Koga, Priscila Faimann Sales, Hellen Karine Santos Almeida, Thiago Afonso Carvalho Celestino Teixeira, José Carlos Tavares Carvalho

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Traditional medicine; phytotherapy; hypoxia; oxidative stress; nephroprotection; antioxidant; anti-inflammatory; diuretic.

Online: 19 June 2023 (03:48:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1273.v1

A New Perspective for the Treatment of Alzheimer’s Disease: Exosome-Like Liposomes to Deliver Natural Compounds and RNA Therapies

Joana Ribeiro, Ivo Lopes, Andreia Castro Gomes

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: neurodegenerative diseases; Alzheimer’s disease; natural compounds; RNA therapy; blood-brain barrier; exosome-like liposomes

Online: 19 June 2023 (03:33:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1269.v1

The Importance of The Tumor Microenvironment

Kornélia Baghy, Andrea Reszegi, Ilona Kovalszky

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: tumor microenvironment; extracellular matrix; proteoglycans; tumor-associated fibroblasts; tumor immunity; immune checkpoint inhibitors; tumor stroma; angiogenesis

Online: 19 June 2023 (03:16:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1266.v1

Brain Injury Plasma Biomarkers in Patients on VA-ECMO: A Pilot Prospective Observational Study

Shrey Kapoor, Syed Ameen Ahmad, Siam Muquit, Aaron Gusdon, Shivalika Khanduja, Wendy Ziai, Allen Everett, Glenn Whitman, Sung-Min Cho

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: ECMO; Extracorporeal membrane oxygenation; Plasma biomarker; Brain injury; neuromonitoring

Online: 19 June 2023 (03:03:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1264.v1

Bronchoalveolar Lavage Cytology in Severe Equine Asthma Syndrome During Asymptomatic, Exacerbation, and Remission Phase: Cytocentrifugated Versus Sedimented Smear Preparations

Maria Morini, Francesca Gobbo, Riccardo Rinnovati, Noemi Romagnoli, Angelo Peli, Chiara Massarenti, Alessandro Spadari, Marco Pietra

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: BAL; Equine Asthma Syndrome; cytocentrifugation; smear; cytology; horse

Online: 19 June 2023 (03:00:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1260.v1

Dual Antiplatelet Therapy or Antiplatelet Plus Anticoagulant Therapy in Patients with Peripheral and Chronic Coronary Artery Disease: an Updated Review

Giulia Magnani, Andrea Denegri, Filippo Luca Gurgoglione, Federico Barocelli, Elia Indrigo, Davide Catellani, Gianluca Signoretta, Alberto Bettella, Domenico Tuttolomondo, Emilia Solinas, Francesco Nicolini, Giampaolo Niccoli, Diego Ardissino

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Coronary artery disease; Peripheral Artery Disease; Polyvascular Diseae; Anti-thrombotic therapy; Personalized treatment

Online: 16 June 2023 (16:17:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1259.v1

Advanced Anterior Eye Segment Imaging for Ichthyosis

Anna Micińska, Anna Nowińska, Sławomir Teper, Joanna Kokot-Lesik, Edward Wylegala

Subject: Medicine And Pharmacology, Ophthalmology Keywords: ichthyosis; cornea; ocular surface; optical coherence tomography; confocal microscopy

Online: 16 June 2023 (15:54:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1256.v1

Renin-Angiotensin System Components and Arachidonic Acid Metabolites as Biomarkers of COVID-19

Biwash Ghimire, Sana Khajehpour, Elizabeth Middleton, Robert A Campbell, Mary Nies, Ali Aghazadeh-Habashi

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Renin-Angiotensin System; Arachidonic Acid; COVID-19; Biomarkers

Online: 16 June 2023 (14:20:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1254.v1

Parkinson's Disease and the Heart: Studying Cardiac Metabolism in the 6-Hydroxydopamine model

Victor Silva da Fonsêca, Valeria de Cassia Gonçalves, Mario Augusto Izidoro, Antônio-Carlos G. de Almeida, Fernando Luiz Affonso Fonseca, Fulvio Alexandre Scorza, Josef Finsterer, Carla Alessandra Scorza

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Parkinson’s disease; cardiac metabolism; heart; 6-hydroxydopamine; metabolites

Online: 16 June 2023 (14:16:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1252.v1

Pain Reduction and Tolerance of Type Ii Undenatured Collagen (Uc-Ii) in Patients With Knee Osteoarthritis

Tomás Fernando Fernández-Jaén, Carlos González de Vega, Paula Sáiz, Per Björk, Elena Rodríguez-Iñigo, Juan Manuel López-Alcorocho, Franchek Drobnic, Pedro Guillén-García

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Native collagen; Osteoarthritis; Food Supplement

Online: 16 June 2023 (14:04:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1248.v1

Sequential and Combined Efficacious Management of Auricular keloid: A Novel Treatment Protocol Employing Ablative CO₂ and Dye Laser Therapy – An Advanced Single-Center Clinical Investigation

Simone Amato, Steven Paul Nisticò, Giovanni Pellacani, Stefania Guida, Anthony Rossi, Caterina Longo, Enzo Berardesca, Giovanni Cannarozzo

Subject: Medicine And Pharmacology, Dermatology Keywords: Auricular keloids, CO2 laser therapy, Dye laser therapy, Multispectral analysis; scar; Vancouver scar scale; Patient and Observer Scar Assessment Scale

Online: 16 June 2023 (13:46:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1245.v1

Significance of Diabetic Kidney Disease Biomarkers in Predicting Metabolic-Associated Fatty Liver Disease

Jaehyun Bae, Byung-Wan Lee

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: diabetic kidney disease; metabolic-associated fatty liver disease; biomarker

Online: 16 June 2023 (13:36:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1237.v1

Validation of Nutritrauma strategy for detection of harmful effects of medical nutritional treatment in critically ill patients in real life

Jordi Parisi, Itziar Martínez de Lagran, Mateu Serra-Prat, Maria Roca, Raquel Merino, Maria del Carmen De la Torre, Lluis Campins, Juan Carlos Yébenes

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Metabolic complications; critically ill; nutritrauma; medical nutrition therapy; enteral nutrition; parenteral nutrition.

Online: 16 June 2023 (12:10:10 CEST)

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Aims: Medical Nutritional Treatment (MNT) can be complex and associated to potential meta-bolic complications, which has been recently described as Nutritrauma. There is no data on the effect of applying this strategy in clinical practice. The aim of our work is to describe if applica-tion of Nutritrauma concept in real live is useful to detect metabolic complications associated to the prescription of MNT in critically ill patients. Methods: In this descriptive prospective study at a single center, we enrolled 30 consecutive crit-ical ill patients of a 14 beds medical – surgical Intensive Care Unit. The Nutritrauma strategy implementation was based in four M steps: Metabolic screening, MNT prescription, Biochemical Monitoring and Nutritional Management. The primary endpoint was to describe the metabolic complications of the MNT detected with Nutritrauma strategy. Secondary endpoint was to de-scribe the most frequent causes of inappropriate prescription. Results: We analysed 28 patients (mean age 69,7 ± 11,3 years; APACHE II 18,1 ± 8,1, SOFA 7,5 ± 3,7; Nutric Score modified 4,3 ± 2,01 and mean BMI 27,2 ± 3,8). The most frequent disease on admission was sepsis (46,4%). Length of ICU stay was 20,6 ± 15,1 days and 39,3% died during the ICU stay. Enteral nutrition (82,1%) was more frequent than parenteral nutrition (17,9%). During nutritional monitoring 54 specific analytical determinations were made. Hyperglycemia was the most frequent metabolic alteration (83,3% of the determinations). Electrolyte disturbance were hypocalcemia (50%), hypophosphatemia (29,6%) and hypokalemia (27,8%). The most frequent lipid profile abnormality were hypocholesterolemia (64,8%) and hypertriglyceridemia (27,8%). Furthermore, nutritional prescription was modified in the 53,6% of patients: increase protein dosage (25%), increase caloric dosage (21,4%) and change to an organ-specific diet (17,8%). Conclusions: The application of Nutritrauma strategy facilitate the detection of metabolic com-plications and the evaluation of the appropiate prescription of the MNT.

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