Textile wastewater containing dyes pose significant environmental hazards. Advanced oxidative processes, especially the heterogeneous photo-Fenton process, are effective in degrading a wide range of contaminants due to high conversion rates and ease of catalyst recovery. This study evaluates the photocatalytic degradation of azo dyes Acid Red 18 (AR18), Acid Red 66 (AR66) and Orange 2 (OR2) using magnetite as a catalyst. The magnetic catalyst was synthesized via a hydrothermal process at 150°C. Experiments were conducted at room temperature, investigating the effect of catalyst dosage, pH, and initial concentrations of H2O2 and AR18 dye. Kinetic and thermodynamic studies were performed at 25, 40 and 60°C for the three azo dyes (AR18, AR66 and OR2) and the effect of the dye structures on the photocatalytic efficiency was investigated. At 25 °C for 0.33 mmol.L-1 of dyes at pH 3.0, using 1.4 g.L-1 of catalyst and 60 mg.L-1 of H2O2 under a UV radiation of 16.7 mW.cm-2 the catalyst showed a 62,3% degradation for AR18, 79.6% for AR66, and 83.8% for OR2 in 180 minutes of reaction. The oxidation of azo dyes under these conditions is spontaneous and endothermic. The pseudo-first order kinetic constants indicated a strong temperature dependence with an order of reactivity of the type: OR2 > AR66 > AR18, which is associated to the characteristics of molecular complexity (size, steric hindrance, aromatic conjugation), electrostatic repulsion and the nature of the acid-base interactions on the catalytic surface.

Based on an in-depth analysis of the factors influencing the compressive strength of ultra-high performance concrete (UHPC), this study examined the impact of both single factors and combined factors on UHPC performance using experimental data. The correlation analysis indicates that cement content, water content, steel fiber, and fly ash significantly affect the strength of UHPC, whereas silica fume, superplasticizers, and slag powder have a relatively smaller influence. This analysis provides a scientific basis for model development. Furthermore, the support vector regression (SVR) model was optimized using the arithmetic optimization algorithm (AOA). The superior performance and computational efficiency of the AOA-SVR model in predicting UHPC compressive strength were validated. Compared to SVR, support vector machine（SVM）, and other single models, the AOA-SVR model achieves the highest R2 value and the lowest error rates. The results demonstrate that the optimized AOA-SVR model possesses excellent generalization ability and can more accurately predict the compressive strength of UHPC.

Background: Sarcopenia is a progressive muscle disorder characterized by muscle wasting, decreased strength, and a substantially elevated risk of developing severe and potentially life-threatening health complications. For decades, muscle wasting has been recognized as a clinical symptom in various severe diseases and conditions. However, with increasing life expectancy and an aging population, sarcopenia has emerged as a prominent age-related condition in primary care, significantly contributing to disability and mortality rates. Aim and Objective: Our goal was to elucidate the clinical characteristics associated with sarcopenia prevalence in postmenopausal women with type 1 osteoporosis. Methodology: 370 postmenopausal osteoporosis patients who routinely visited the physiotherapy department at Ali Fatima Hospital were examined in this cross-sectional investigation. Mean age 64.59 ± 5.85 years, it was discovered that the patients' quality of life, postural stability, muscular strength, and balance were related to the existence of sarcopenia. Conclusion: In summary, among postmenopausal female patients with type 1 osteoporosis, the incidence of sarcopenia was relatively high (90.35%), affecting quality of life in 39.82% of patients, postural instability in 92.21% of patients, and balance in 39.92% of patients.

Statistics modules are included in most university degrees, independent of the degree area. They have an important role in preparing students for the real world. The overall goal of this paper is to identify the common statistical issues students face during the transition from secondary education to tertiary education. Drawing upon data from the University College Dublin (UCD) Math Support Center (MSC) and Universidad Rey Juan Carlos (URJC), our approach aims to optimize learning experiences while advancing sustainability objectives. In this paper, we conducted a categorization of statistical concepts taught in university (based on URJC). Using this categorization, UCD MSC tutor comments were categorized and validated, and subsequently descriptive analyses and text mining were used on the UCD MSC comments to achieve a deeper understanding of the statistical issues. Building on this study, we plan to develop a suite of evidence-based sustainable educational applications and games to support undergraduate students internationally in first-and second-year statistical modules. Our findings on students’ main statistical issues contribute to the cultivation of lasting statistical literacy among students. This research advances the sustainability agenda within statistical education.

In previous studies, drones have been used to carry out visual inspections of heritage elements. In order to complement the information obtained with the common drone, a new underwater drone model is proposed for the specific case of old bridges. The aim is to verify the applicability of underwater drones for the inspection of submerged elements of old heritage bridges, given the large number of bridge disasters and collapses linked to failures in their foundations. To this end, we carried out an underwater inspection of the visible submerged elements (submerged but not buried) of three old bridges crossing different rivers. The different locations and characteristics of these bridges allow us to draw some initial conclusions. The results of the operations carried out show that underwater drones are not only useful for this type of inspection, but that the work is much safer than with the means currently used (underwater divers). In addition, the use of drones makes it possible to study certain parameters that can anticipate subsequent foundation problems affecting the entire bridge, such as the settlement or rotation of piers or abutments.

The cyclamen mite, Phytonemus pallidus, is one of the important pests in strawberry cultivation in Canada. This insect pest hides on young strawberry leaves that have not yet opened, which limits their control. In addition, the fight against the latter involves the use of synthetic chemicals that are not without effect on the environment, human health and beneficial organisms. We hypothesized that vectorization by bees could reduce the number of applications, product runoff and provide targeted control of these pathogens. To do this, field trials were conducted to evaluate the effectiveness of bumblebees Bombus terrestris in propagating Beauveria bassiana to control this pest. Our results showed that bumblebees were able to disseminate the inoculum on strawberry plants. Also, all the products used (B. bassiana and neem oil) were effective on P. pallidus. It should be noted that high mortality has been noted on this pest thanks to the application of this entomopathogen by spraying. In addition, neither of the two products tested had a significant effect on lady beetles C. septempunctata. These results therefore suggest the use of bee vectoring and neem essential oils in the sustainable management of strawberry mites.

This paper is concerned about the novel exact solitons to the truncated M-fractional (1+1)-dimensional non-linear generalized Bretherton model with arbitrary constants . This model is used to explain the resonant nonlinear interaction between the waves in different phenomenon, including fluid dynamics, plasma physics, ocean waves, and many others. A series of exact solitons, including bright, dark, periodic, singular, singular-bright, singular-dark, and other solitons are obtained by applying the extended sinh-Gordon equation expansion (EShGEE), and the modified (G′/G2)-expansion tech- niques. A novel definition of Fractional derivative provides the solutions distinct from the present solutions. Mathematica software is used to obtain, and verify the solutions. The solutions are shown through 2-D, 3-D, and density plots. The stability process is performed to verify that the solutions are exact and accurate. The modulation instability is used to determine the steady-state stable results to the corresponding equation.

Background The aims of this study were to assess the peri-operative morbidity, mortality and long-term survival of octogenarians undergoing ATAAD repair, and to compare open and closed distal anastomosis techniques. Methods This was a single-centre retrospective study (2007-2021). Open versus closed distal anastomosis were compared. Uni and multi-variable logistic regression analyses were performed to identify independent predictors of in-hospital mortality. Kaplan-Meier and Cox proportional hazards methods were used to compare long-term survival. Results Fifty octogenarians patients were included (median age - 82 years, closed distal – 22, open distal - 28). Median CPB time was 187 minutes (open distal vs closed distal group; 219 minutes vs 115.5 minutes, p30 days or return to theatre; HR; 4.1, p=0.02) predicted adverse survival. Open distal anastomosis did no impact survival. Conclusions – ATAAD repair in selected octogenarians has favourable short and long-term survival. There is no significant difference between open versus closed distal anastomosis strategies.

There is paucity of data in the available medical literature regarding the parameters of volumetric perfusion of pancreas grafts. Materials and methods From February 5, 2016 to December 23, 2021, we performed perfusion computed tomography in 41 patients at different times after simultaneous pancreas and kidney transplantation. The study group consisted of 18 men (44%) and 23 women (56%) with a long history of type 1 diabetes complicated by terminal chronic renal failure. The results of perfusion computed tomography of the pancreas graft were studied, and the effects of post-transplantation timing and graft revascularization peculiarities on volumetric perfusion parameters were evaluated. Results The median arterial blood flow, arterial blood volume, and permeability of the pancreas graft were 115.1 [99.7;130.3] mL/100 mL/min, 46.7 [37.4;56.9] mL/min and 8.6 [4.1;11.4] mL/100 mL/min, respectively. No statistically significant differences in the averaged perfusion values were found in the head, body, and tail of the pancreas graft. The post-transplantation timing and the number of arteries involved in graft revascularization did not have a significant effect on the volumetric perfusion of the graft. Conclusion The volumetric perfusion results of the pancreas graft correspond to those obtained in the study of pancreatic perfusion in healthy participants.

The research of tangible creativity support tools (T-CSTs) has been increasing in recent years. However, there is a lack of review that interprets what T-CSTs trends must be considered and how challenging opinions should be broken. Hence, a focused and critical review of existing studies is necessary. This paper analyzed 86 studies related to T-CSTs following the PRISMA protocol. First, the research tendencies were extracted and provided a basic knowledge construction. Then, we extracted primary research questions, categorized the adopted design and technological solutions, and identified the researchers’ hypotheses-validation. Last, we proposed research gap, challenge and potential opportunities for future researchers and designers. This review will benefit people in the fields of tangible interaction, design studies and education.

This research evaluates the feasibility of addressing computer vision problems with limited resources, particularly in the context of medical data where patient privacy concerns restrict data availability. (1) Background: The study focuses on diagnosing skin diseases using five distinct transfer learning models based on convolutional neural networks. Two versions of the dataset were created, one imbalanced (4092 samples) and the other balanced (5182 samples), using simple data augmentation techniques. Preprocessing techniques were employed to enhance the quality and utility of the data, including image resizing, noise removal, and blur techniques. The performance of each model was assessed using fresh data after preprocessing. According to the research findings, (2) Methods: the VGG-19 model achieved an accuracy of 95.00% on the imbalanced dataset. After applying augmentation on the balanced data, the best-performing model was VGG-16-Aug with an accuracy of 97.07%. (3) Results: These results suggest that low-resource approaches, coupled with preprocessing techniques, can effectively identify skin diseases, particularly when utilizing the VGG-16-Aug model with a balanced dataset. (4) Conclusions: The study addresses rare skin disorders that have received limited attention in past research, including acne, vitiligo, hyperpigmentation, nail psoriasis, and SJS-TEN. The findings highlight the potential of simple data augmentation techniques moreover, explainable AI: Grad-CAM interpreted the model outcome by showing image contours visually as well as identifying uncommon skin conditions and overcoming the data scarcity challenge. The implications of these research findings are significant for the development of machine learning-based diagnostic systems in the medical field. Further investigation is necessary to explore the generalizability of these findings to other medical datasets.

Heterosis of growth traits in economic fish has benefited the production of aquaculture for many years, yet its genetic and molecular basis has been remained obscure. Nowadays, a new germplasm of hybrid Jinhu grouper (Epinephelus fuscoguttatus♀ × E. tukula♂), exhibiting paternal-biased growth heterosis, has provided an excellent model for investigating the potential regulatory mechanisms of heterosis. We integrated transcriptome and methylome to unravel the changes of gene expression, epigenetic modification, and subgenome dominance in Jinhu grouper compared with maternal E. fuscoguttatus. Integration analyses showed that the heterotic hybrids showed lower genomic DNA methylation levels than the purebred parent, and the up-regulated genes were mostly DNA hypomethylation. Furthermore, allele-specific expression (ASE) detected paternal subgenome dominance regulated paternal-biased heterosis, and paternal bias differentially expressed genes (DEGs) were wholly up-regulated in the muscle. Muti-omics results highlighted the role of lipid metabolism, particularly “Fatty acid synthesis”, “EPA biosynthesis”, and “Signaling lipids”, in Jinhu grouper heterosis formation. Coherently, our studies have proved that the eicosapentaenoic acid (EPA) of Jinhu grouper was greater than that of maternal E. fuscoguttatus (8.46% vs 7.46%). Finally, we constructed a potential regulatory network for control of the heterosis formation in Jinhu grouper. Among them, fasn, pparg, dgat1, igf1, pomca, fgf8a, and fgfr4, were identified as key genes. Our results provide new and valuable clues for understanding paternal-biased growth heterosis in Jinhu grouper, taking a significant step towards the molecular basis of heterosis.

There is a lack of studies on the level of stress and health of families of workers in road transport. This study aimed to evaluate the perceived stress level and Family Effectiveness of family members of road transport workers. A quantitative study was carried out with family members of road transport workers in the southern region of Brazil. For the data collection, a sociodemographic form, the Perceived Stress Scale (PSS), and the Evaluation of Family Effectiveness Strategies were used. The data were analyzed by simple frequency, Spearman correlation coefficient (ρ) (p < 0.05), and descriptive analysis from the perspective of the Systemic Organization. 49 family members of road transport workers were participants. Perceived stress was higher in family members who had more than nine years of schooling, the targets of Control and Growth were higher in the evaluation of Family Effectiveness. The Control target was also higher in families with more than three people. The Coherence dimension had higher levels in families with health problems and whose income was less than $792.00 US dollars per month. In the Individuation dimension, income over $792.00 had better results. The Maintenance dimension of the system was higher in families whose drivers’ activity was as an intercity driver, as well as in the Stability target. In conclusion, the social factors such as schooling, income, diseases, type of worker activity in road transport, and number of people in the family influenced perceived stress and Family Effectiveness, which demonstrates the need to increase the promotion of health care of the families of road transport workers.

Despite copious research, the methods for assessing upper- and lower-limb motor coordination are limited. We devised a simplified evaluation method based on upper- and lower-limb motor coordination jumping and conducted a practical examination of the characteristics of the motion and applicability of the evaluation method. Overall, 88 high-school athletes with comparable competitive abilities were included in this study. The participants were divided into two groups based on their prior experience with motor coordination training (24 in the experienced group; 64 in the inexperienced group). First, a population proportion test was employed to assess the success rate of the four upper- and lower-limb motions in each task. This revealed significant difference between all tasks, except for the fourth motion, indicating that different motions have varying degrees of difficulty and that the combination of motions with differing difficulty coefficients can result in the creation of entirely new tasks with varying degrees of difficulty. Second, the experienced group demonstrated significantly superior performance compared to the inexperienced group by a t-test. These results confirmed that athletes (with the same level of competitive ability) trained in upper and lower limb motor coordination were able to excel in this evaluation method, confirming its validity.

The optical characteristics and electrical behavior of zinc oxide nanorods (ZnO-NR) and silver nanoparticles (Ag-NP) were investigated using advanced scanning probe microscopy and spectroscopy techniques. The study revealed that the ZnO nanorods have a length of about 350 nm, while the Ag nanoparticles are spherical with heights ranging from 5 to 14 nm. Measurements with Kelvin Probe Force Microscopy (KPFM) showed that the work functions of ZnO nanorods are approximately 4.55 eV, higher than that of bulk ZnO, and the work function of Ag nanoparticles ranges from 4.54 to 4.56 eV. The electrical characterization of ZnO nanorods, silver nanoparticles, and their hybrid was also conducted using conductive atomic force microscopy (C-AFM) to determine the local current-voltage (I-V) characteristics, which revealed a characteristic similar to that of a Schottky diode. The current-voltage characteristic curves of ZnO nanorods and Ag nanoparticles both show an increase in current at around 1V, and the hybrid ZnONRs/AgNP exhibits an increase in turn-on voltage at around 2.5 Volts. This suggests that the presence of Ag nanoparticles enhances the electrical properties of ZnO nanorods, improving charge carrier mobility and conduction mechanisms through a Schottky junction. The investigation also explored the optical properties of ZnO-NR, AgNP, and their hybrid, revealing absorption bands at 3.11 eV and 3.18 eV for ZnO-NR and AgNP, respectively. The hybrid material showed absorption at 3.13 eV, indicating enhanced absorption, and the presence of AgNP affected the optical properties of ZnO-NR, resulting in increased photoluminescence intensity and slightly changes in peak positions.

The use of individual protective covers (IPCs) to protect newly planted citrus trees from HLB infection is being widely adopted in Florida, an HLB endemic citrus producing area. It is known that IPCs positively influence most horticultural traits, increasing tree growth, flush expansion, and leaf size enabling trees to sustain a balanced carbohydrate metabolism by preventing CLas infection and induced higher leaf chlorophyll levels. This may result in more productive trees. However, as the tree grows IPCs eventually are removed, typically between 2 and 3 years after initial installation. Once IPCs are removed, trees become exposed to the ACPs and ultimately become infected. In this work we covered trees from Valencia sweet orange with IPCs for 30 months, until the trees entered fruit bearing age. We investigated how IPC protection of newly planted trees for 30 months influenced fruit quality and yield of ‘Valencia’ trees for three consecutive seasons after IPC removal compared to non-covered trees. The use of IPCs kick-started the newly planted citrus trees, resulting in more yield and fruits with better internal and external quality. After 30 months of IPC protection, tree canopies were larger and denser supporting more fruit per tree than in non-protected trees for three consecutive seasons even though by the end of the first season after IPC removal trees were HLB positive. Tree height, scion diameter, canopy volume, and leaf area were significantly improved as compared to non-covered trees. Additionally, fruit quality was significantly improved in the three seasons following IPC removal as compared to non-covered trees. However, a decline in quality was measurable in fruit from IPC trees after the second harvesting season, with trees affected by HLB. Based on the results from this study, we conclude that benefits from IPC protection may last for at least three consecutive seasons once trees enter the productive age despite CLas-infection within 12 months after IPC removal.

This paper proposes an unusual method for the dissemination of geological sciences and the promotion of geotourism: the scientific documentary, where a representative itinerary of geological and geomorphological evolution of this portion of the Apennines was presented. The considerations that led to the identification of the geological route proposed to the editorial staff of FOCUS TV are presented in detail. At each stop there was an explanation by academic professors and researchers, mainly from the Geology Division of the University of Camerino (MC), who explained in detail the outcrops. During the episode, insights were also given into the anthropogenic frequentation of the epigean caves in Frasassi (AN), ancient places of frequentation and worship thanks to their suggestiveness and the sense of sublime that they can elicit. In addition to the illustration of the individual stops, the article offers further insights into the geomorphology of the most important geosites depicted, all of which are in nature parks or protected areas and characterized by a high landscape value. The result was the production of an episode of the television program 'Geological Wonders of Italy: The Marche and Umbria Regions', which was broadcast in October 2022 by the Italian national Mediaset group.

The importance of diet shaping the gut microbiota is well known and may help with improving the overall health of an individual. Many other factors also have an influence, such as genetics, age, exercise, antibiotic therapy, or tobacco use. The purpose of this review is to summarize how three distinct dietary types (plant-based diet, Mediterranean diet, and Western diet) affect the composition of gut microbiota and the development of non-communicable diseases (NCDs). PubMed, Web of Science and Scopus databases were used for searching papers with an emphasis on keywords ‘‘dietary pattern’’, ‘‘gut microbiota’’ and ‘‘dysbiosis’’. Plant-based diet and Mediterranean diet promote the production of beneficial bacterial products, and more microbial diversity and therefore are generally considered healthy dietary types. On the other hand, the Western diet is a typical example of an unhealthy approach to nutrition which leads to an overgrowth of pathogenic bacteria. Moreover, understanding the impact of diet on the modulation of gut microbiota may give rise to new therapeutical strategies.

This study delves into the transformative growth of private higher education in China, highlighting the rapid and diverse expansion following the COVID-19 pandemic. Although previous studies have reported expansion and difficulties, a thorough examination of the relationship between institutional adaptation and the development of human capital remains unexplored. This study examines how private higher education institutions modify their job-related courses to suit the demands of the job market, evaluates the effect on the employability of graduates, and investigates ways to control costs without sacrificing academic quality. This study analyzes data from the Ministry of Education, Wind Information, and Shenwan Hongyuan Research to gain insights into the impact of human capital theory and institutional theory on private higher education in China. Enrollment trends, program alignment, financial sustainability, and quality enhancement activities are all examined using detailed analysis. Private higher education institutions play a critical role in developing a skilled labor force by filling skill gaps and meeting the demands of an evolving job market. The findings also emphasize the importance of quality assurance procedures, strategic program development, and collaborations with businesses. In conclusion, the study emphasizes the imperative for more research and policy action. This is crucial to securing the lasting effectiveness and influence of private higher education institutions on China's socioeconomic progress and human capital development in the post-pandemic era.

A favorable physical environment in the soil is necessary and of fundamental importance for the growth and root development of the sorghum crop, in order to maximize the productivity of the planted crops. In this study we evaluated the physical aspects of the soil in no-tillage system in a sorghum grain area intercropped with Urochloa ruziziensis and Crotalaria spectabilis and the productivity of the crop, in off-season (second crop season), based in a long field experiment. The experimental design was a randomized block design in a 4 x 4 factorial arrangement (four cropping systems: sorghum, sorghum + Urochloa ruziziensis, sorghum + Crotalaria spectabilis, sorghum + Urochloa ruziziensis + Crotalaria spectabilis; four soil depths: 0 - 0.10 m, 0.10 - 0.20 m, 0.20 - 0.30 m, 0.30 - 0.40 m). It was analyzed the productivity and the physical soil attributes that were: Soil Bulk Density (DS), Gravimetric Moisture (GM), Total Porosity (TP), Microporosity (MI), Macroporosity (MA) and Resistance to Root Penetration (RP). The study asserts that intercropping sorghum with Crotalaria spectabilis is a promising strategy to increase productivity. The Sorghum + Urochloa ruziziensis + Crotalaria spectabilis combination significantly improves soil structure by reducing penetration resistance and increasing macroporosity, especially at depths greater than 0.20 m. The inclusion of Urochloa enhances moisture retention, while Crotalaria contributes to greater porosity.

Wetlands are ecosystems that are essential to ecological balance and biodiversity, never-theless human activity is a constant threat to them. Excess nutrients are caused by inten-sive livestock and agricultural operations, pollution, and population growth, which in turn leads to uncontrolled microbiological development. This impairment in water quality can constitute a risk to animal, human, and environmental health. To thoroughly charac-terize the microbial communities, shotgun metagenomics was used to characterize the taxonomic and functional pattern of microorganisms that inhabit urban wetlands in the Los Lagos Region of Chile. The main objective was to identify microorganisms of veteri-nary relevance, assess their potential antibiotic resistance, and characterize the main vir-ulence mechanism. As expected, a high diversity of microorganisms was identified, in-cluding bacteria described as animal or human pathogens. Also, a diverse repertory of an-timicrobial-resistant genes (ARGs) was detected, which confers mainly resistance to be-ta-lactams, consistent with the families of antibiotics most used in Chile. Besides, a di-verse collection of virulence mechanisms was also identified. Given the significance of the relationship between environmental, animal, and human health—a concept known as One Health—there is a need to establish molecular surveillance programs. This work is the first report of the presence of these harmful biological elements in urban wetlands subjected to anthropogenic pressure, located in the south of Chile.

Despite some advances in controlling progression of Prostate Cancer (PCa) that is refractory to the use of ADT/ARSI, most patients eventually succumb to the disease, and there is a pressing need to understand the mechanisms that lead to the development of CRPC. A common mechanism is the ability to integrate AR signals from vanishing levels of testosterone, with the frequent participation of YAP as a coactivator, and pointing to deregulation of the Hippo pathway as a major determinant. We have recently shown that YAP is post-transcriptionally activated via the TLK1>NEK1 axis by a stabilizing phosphorylation at Y407. We are now solidifying this work by showing that: 1) The phosphorylation of Y407 is critical for YAP retention/partition in the nuclei, and that J54 (TLK1i) reverses this along with YAP407 dephosphorylation. 2) That the enhanced degradation of (cytoplasmic) YAP is increased by J54 counteracting its Enzalutamide-induced accumulation. 3) That the basis for all these effects, including YAP nuclear retention, can be explained by the stronger association of pYAP-Y407 with its transcriptional co-activators, AR and TEAD1. 4) We demonstrate that ChIP for GFP-YAP-wt, but hardly for the GFP-YAP-Y407F mutant, at promoters of typical ARE- and TEAD1-driven genes is readily detected but becomes displaced after treatment with J54. 5) While xenografts of LNCaP cells show rapid regression following treatment with ARSI+J54, in the VCaP model, driven by the TMPRSS2-ERG oncogenic translocation, tumors initially respond well to the combination but subsequently recur, despite the continuous suppression of pNek1-T141 and pYAP-Y407. This suggests an alternative parallel pathway for CRPC progression for VCaP tumors long-term, that may be separate from the observed ENZ-driven YAP deregulation, although clearly some YAP gene targets like PD-L1, that are found accumulate following prolonged ENZ treatment, are still suppressed by concomitant addition of J54.

This study explores the impact of artificial intelligence (AI) on financial inclusion satisfaction and recommendation, focusing on ethical dimensions and perceived algorithmic fairness. From the perspectives of organizational justice theory and the heuristic-systematic model, we examine how constructs of algorithm transparency, algorithm accountability, and algorithm legitimacy influence users' perceptions of fairness, and subsequently, their satisfaction with and recommendation of AI-driven financial inclusion. Through a survey-based quantitative analysis, our results indicate that perceived algorithmic fairness acts as a mediating factor between the ethical attributes of AI systems and user satisfaction as well as their recommendation. Findings reveal that higher levels of transparency, accountability, and legitimacy enhance customers' perceptions of fairness, which in turn significantly increases both their satisfaction with financial inclusion services facilitated by AI and their likelihood to recommend them. This research not only contributes to the literature on AI ethics by highlighting the critical role of transparent, accountable, and legitimate AI practices in fostering satisfaction and recommendation among users, but also fills a significant gap in understanding the ethical implications of AI in financial inclusion contexts.

In this paper, we derive a formula for sum of powers of integers from Abel’s Summation Formula. This formula enables us to generate the formula for the sum of k-th power of integers, denoted by Sk(n), given the formulas of S1(n), S2(n), ..., Sk−1(n). Furthermore, we shall extend this formula to compute the sum of powers of an arithmetic progression. Moreover, we can combine the formula with the result of Bernoulli to derive another result which enables us to find Bernoulli Numbers recursively.

The present study aimed to date the death of Korean red pine (Pinus densiflora Siebold & Zucc.) at Sogwang-ri, where is famous for the Korean red pine forests in Korea, using a dendrochronological method, and to investigate the effect of climatic factors on the death and growth decline of the pine trees. For the study, 51 Korean red pines were selected from three stands (Jungmi-gol A, Jungmi-gol B, and Neonam-gol) in the study area, and for the ring-width measurement the increment cores were extracted from the selected trees. The stand chronologies for the Jungmi-gol and Neonam-gol were established using the mean values of individual time series of the living trees from each site, and the chronologies were further used for cross-dating with individual time series of the dead trees to date their death. The abrupt growth reduction was also investigated based on the consecutive ring-width growth decline trend to know the vitality during the living. Results revealed that the red pines at Jungmi-gol A were dead in 2020, at Jungmi-gol B in 2012 or 2013, and at Neonam-gol in 2019. So, it was verified that the death of the red pines at the study sites occurred from high to low elevations. In the analysis of the role of climate in the annual ring growth, the trees at Jungmi-gol A and B located on the southwest slope showed more ring-width growth when precipitation in April, July, and August were increasing, at Neoman-gol located on the north slope when precipitation only in July was increasing. Although the correlations of the ring-width growths at the sites with temperature and precipitation were somehow different from each other, Drought Stress Index (DSI) from May to September at all sites were all negative. Therefore, water stress caused by increased temperature and decreased precipitation is the most significant climatic parameter for the death or growth decline of the pine trees in the study area.

Cocoa bean shells (CBSs) represent the external layer of cocoa beans. The shells are removed during the winnowing after the pre-roasting, a processing step of chocolate production; in in the past they were considered a waste. CBSs possess many interesting nutritional characteristics in both macro and micronutrients. CBSs result very rich in dietary fiber and antioxidant compounds such as phenolic acids and flavan-3-ols. Soluble dietary fibers are potentially associated with fermentability and prebiotic activity on human gut microbiota instead antioxidants compounds have been linked with positive effects on human health. Based on these properties, the aim of this study was the valorization of CBSs thorough enzymatic treatments. The shells were treated both raw and defatted; three sets of carbohydrases have been used in order to destructure the fiber profile, potentially enhancing the potential prebiotic activity of CBSs. Cellulase, xylanase and pectinase were used to perform enzymatic treatments. After the enzymatic hydrolisis, both soluble and insoluble fibers fraction were quantified, in parallel with the total phenolic and the total flavonoid contents and the antioxidant activity. Moreover, the HPLC-PDA analysis was carried out for the main compounds of CBSs. The enzymatic treatmens allowed to obtain an enhancement in soluble fibers, for both defatted and raw CBSs, particularly using cellulase, xylanase and their combinations. Finally, a parallel preservation of the antioxidant capacity and the content of the main bioactive compounds after the treatments was observed. These results can be used to exploit the enzymatic treated CBSs to further industrial applications in the food and nutraceutical fields.

This paper explores the feasibility of applying Bayesian statistical methods to study the distortion patterns induced by carburizing heat treatment. By establishing posterior and predictive distribution models for torsion bar dimensions, we aim to accurately understand and predict the expansion behavior, thus enhancing control over carburizing-induced dimensional changes. Bayesian methods allow for the integration of prior knowledge and real-time data, providing a more comprehensive understanding of the distortion phenomena. This approach not only improves the precision of dimensional predictions but also contributes to optimizing the overall manufacturing process, ensuring that the torsion bars meet the rigorous standards required for high-performance applications in demanding industrial environments.

This study provides a thorough examination of the introduction of 5G technology in Bangladesh's agriculture sector, providing insights into the problems and potential implications related to its adoption. Focusing on the contextual landscape of Bangladesh, the study evaluates the effectiveness, efficiency, scalability, and ease of implementation of 5G technology concerning key challenges faced by the agricultural sector. Drawing comparisons with global perspectives, including countries such as China, Taiwan, Colombia, Netherlands, and India, the analysis provides a nuanced understanding of the diverse technological landscapes. The examination encompasses the evolution from 4G to 5G, emphasizing the commitment of major telecommunications providers in Bangladesh to advance technological capabilities. The challenges in rural adoption, limited technology literacy among farmers, and high smartphone costs are discussed, highlighting potential barriers to seamless integration. To address the creation of a more comprehensive technological infrastructure, the study also explores the efforts and regulatory support provided by the government and the Bangladesh Telecommunication Regulatory Commission (BTRC). Furthermore, the comparative analysis sheds light on the unique characteristics and advancements in other countries, contributing to a holistic understanding of 5G's role in transforming global agricultural practices. By exploring the anticipated socio-economic factors influencing the pace and success of 5G adoption in the agricultural sector, this paper emphasizes the need for collaborative efforts, infrastructure development, and addressing accessibility challenges to achieve widespread agricultural technology integration.

With the digital transformation of the logistics industry, smart logistics algorithms have become a core technology to improve efficiency and reduce costs. This paper reviews the development history of traditional logistics technology and discusses the key role of technologies such as the Internet of Things, big data analysis, artificial intelligence, and automation in logistics technology innovation. It focuses on the application of intelligent logistics algorithms in path optimization, intelligent scheduling, data mining and prediction, and intelligent warehousing. To solve the problem of inconsistency between training and testing objectives, this paper proposes DRL4Route, a deep reinforcement learning-based path optimization framework, and designs the DRL4Route-GAE model. Validated through extensive offline experiments and online deployments, the model significantly outperforms existing optimal benchmark methods on real datasets, improving the location deviation squared metrics and the top-three location prediction accuracy metrics. These research results provide important support to further promote the intelligent development of the logistics industry.

Alpha emitters like plutonium pose severe health risks when ingested, damaging DNA and potentially causing cancer. Traditional detection methods require proximity within millimeters of the contamination source, presenting safety risks and operational inefficiencies. Long-range detection through alpha radioluminescence (RL) offers a promising alternative. However, most of the previous experiments have been carried out under controlled conditions that preclude the overwhelming effect of ambient light. This study demonstrates successful detection of a 3 MBq alpha emitter in an open environment using a newly developed, lightweight compact alpha camera. This camera incorporates a deep-cooled CCD and a specially designed lens system with a low f-number to maximum the signal intensity. The lens was also designed to minimize blue shift effects of filters. Nighttime imaging was achieved with a dual-filter system using a sandwich filters assembly centered at 337 nm and 343 nm for capturing alpha RL and subtracting background light, respectively. At night, the alpha source was detected from 1 meter away within one minute. The system was also evaluated under simulated urban lighting conditions. For daytime imaging, a stack of tilted 276 nm short pass filters minimized sunlight interference, enabling clear detection of the alpha source at 70 cm within 10 minutes under indirect sunlight. This research not only underscores the viability of long-range optical detection of alpha emitters for environmental monitoring and scientific research but also highlights its ability to enhance nuclear safety and public health in real-world settings.

This qualitative study explores the pivotal roles of trust and communication in supplier relationship management (SRM) within the e-commerce sector. Drawing on interviews and thematic analysis, the study examines how trust, comprising dimensions of competence, benevolence, integrity, and reliability, underpins collaborative partnerships and operational resilience between e-commerce platforms and suppliers. Effective communication strategies, including proactive engagement, transparent feedback mechanisms, and real-time updates via digital platforms, are identified as critical enablers for enhancing information exchange and fostering mutual understanding in SRM. Challenges such as cultural differences, technological complexities, and regulatory compliance requirements are also discussed, highlighting the need for strategic management and investment to mitigate risks and maintain trust in supplier engagements. Relational competencies such as empathy, active listening, conflict resolution, and trust-building skills are recognized as essential for navigating interpersonal dynamics and fostering collaborative relationships in e-commerce SRM. Strategically, integrating these findings into comprehensive SRM frameworks is emphasized to cultivate a positive organizational culture characterized by openness, ethical integrity, collaboration, and adaptability. This approach aims to enhance supplier relationships, drive innovation, and achieve sustainable growth in a competitive marketplace.

In Thailand, thousands of children living with perinatal HIV have been exposed to HIV-related stigma/discrimination but its frequency and expressions have been little studied. Our objective was to assess stigma/discrimination prevalence, associated risks factors and its expressions among adolescents. All caregivers of adolescents aged 12-19 years living with perinatal HIV and receiving antiretrovirals in 20 hospitals throughout Thailand were invited to complete a face-to-face questionnaire on their adolescent’s life and medical history. Of the 572 adolescents living in family settings, 464 had their HIV-status known in the community. The overall stigma/discrimination prevalence was 46%. Factors associated included living in the north-east region (OR: 2.80, 95%CI: 1.19-4.96), having a low intellectual ability (OR:2.68, 95%CI: 1.45-5.16), a lower Body Mass Index (BMI) (OR BMI > 18.5: 0.61, 95%CI: 0.37-0.98), conflicts with caregivers (OR: 1.86, 95%CI: 1.26-2.76) and caregivers being members of a support group (OR: 2.34, 95%CI: 1.58-3.48). Expressions of stigma/discrimination included bullying, social isolation, behavioral discrimination and public disclosure. The prevalence of stigma/discrimination among adolescents living with perinatal HIV is high. Despite existing policies, stigma eradication remains necessary to normalize their life as they grow into adulthood.

The understanding of the natural water cycle, also known as the hydrological cycle, has evolved significantly from early philosophical contemplations to the contemporary scientific models employed today. Ancient Greek philosophers initiated this development, and further progression occurred during the Renaissance and Enlightenment periods through empirical research. The 19th and 20th centuries witnessed transformative impacts with technological advancements. Notably, the Quran contains descriptions of the water cycle that align with contemporary scientific knowledge. This study underscores the timeless accuracy of the Quranic verses, which remain unaffected by the era in which they were revealed and align with the latest scientific discoveries.

The catastrophic twin earthquakes that struck southern Turkey and northern Syria on February 6 2023, caused massive casualties and extensive damage to infrastructure, with the province of Hatay bearing the brunt of the impact. To investigate the potential of nighttime light (NTL) data for earthquake disaster assessment, we performed an analysis of pre- and post-earthquake NPP-VIIRS and SDGSAT-1 NTL data. The NTL change ratio (NCR) was employed to identify the extent of damage in Hatay Province following the earthquake to assess the impact on affected buildings and populations. NPP-VIIRS daily NTL Time-series data was used to establish an economic recovery framework for earthquake disasters in Hatay Province, assessing regional economic recovery after earthquake. The results revealed a strong correlation between the total reduced NTLs of NPP-VIIRS and SDGSAT-1 and the presence of severely and moderately damaged buildings. Conversely, the correlation with slightly damaged buildings was relatively weaker. Furthermore, the reduced NTLs of NPP-VIIRS provide a more precise identification of all earthquake damage compared to the SDGSAT-1 data, achieving an overall accuracy of 86.21% in earthquake damage identification and a Kappa coefficient of 0.72. In accordance with the earthquake economic recovery framework, as of the end of March 2024, neither the provincial economy nor any of its districts have fully restored to their pre-earthquake levels. The findings offered new and valuable insights into earthquake disaster assessment, assisting decision-makers in accurately assessing the level of disaster risk following an earthquake and efficiently allocating post-earthquake relief funds.

This study investigates the effect of oil viscosity on pollutant emissions and fuel consumption of an internal combustion engine (ICE) in high-altitude using Response Surface Methodology (RSM). A Chevrolet Corsa Evolution 1.5 SOHC gasoline engine was used in Cuenca, Ecuador (2560 meters above sea level), testing three lubricating oils with kinematic viscosities of 9.66, 14.08, and 18.5 cSt under various engine speeds and loads. Key findings include: hydrocarbon (HC) emissions were minimized to 7.25 ppm with low viscosity and load; carbon dioxide (CO2) emissions peaked at 15.2% vol with high viscosity and load; carbon monoxide (CO) ranged from 0.04% to 3.74% depending on viscosity and load; nitrogen oxides (NOx) were significantly influenced by viscosity, RPM, and load, indicating a need for model refinement; and fuel consumption was significantly affected by load and viscosity. RSM-based optimization identified optimal operational conditions with a viscosity of 13 sCt, 1473 rpm, and a load of 78%, resulting in 52.35 ppm of HC, 13.97% vol of CO2, 1.2% vol of CO, 0 ppm of NOx, and a fuel consumption of 6.66 l/h. These conditions demonstrate the ability to adjust operational variables to maximize fuel efficiency and minimize emissions. This study underscores the critical role of optimizing lubricant viscosity and operational conditions to mitigate environmental impact and enhance engine performance in high-altitude environments.

The phenotypic manifestation of lead toxicity includes cognitive, learning, and memory decline which is associated with neuronal injuries and death and been a major challenge in public health especially in developing countries. Thus, we explore the prophylactic potentials of luteolin in prefrontal Pb intoxication. Thirty-six (36) male Wistar Rats were used for this research and di-vided into six (6) groups of six animals each and were treated orally as follows: Group 1-Normal saline (0.5ml daily for 14 days); Group 2- PbCl3 (50mg/kg of PbCl3 daily for 14 days); Group 3- luteolin (100mg/kg of LUT daily for 14 days); Group 4- luteolin and PbCl3 (50mg/kg PbCl3 and 100mg/kg LUT daily for 14 days); Group 5- PbCl3 then luteolin (50mg/kg of PbCl3 daily for 14 days followed by 100mg/kg of LUT daily for 14 days); Group 6- luteolin then PbCl3 (100mg/kg of LUT daily for 14days followed by 50mg/kg of PbCl3 daily for 14 days). We measured cerebral oxidative redox parameters, G6PDH, IL-6, acetylcholinesterase levels, and total protein profiles using ELISA and biochemical assay kits. We also examined cerebral morphology and the Nissl profile with H&E and toluidine blue staining techniques, as well as astrocytic morphology and synaptic integrity with anti-GFAP and anti-synaptophysin antibodies. As a result of Pb perturba-tion, luteolin treatment inhibits MDA, IL-6, and AChE expression while increasing antioxidant enzyme activities (SOD, GPx) and G6PDH. Furthermore, luteolin has significant prophylactic po-tential against Pb-induced neuronal injuries and modulates astrocyte actions, preserving synap-tic integrity and thus improving cognition, learning, and memory. Taken together, our findings indicate that luteolin may be a promising candidate for managing and treating Pb neural intoxi-cation.

Herein, we investigated hydrogels composed of boronic Acid functionalized alginate and blended with polyvinyl alcohol of different molecular weights to control the release of metoclopramide hydrochloride (MTC) as a function of pH and shear stress. The functionalization of alginate introduced dynamic covalent bonding and pH-responsive properties that can modulate network connectivity. The study investigated the viscoelastic properties of the hydrogels, their drug release profiles, and their responsiveness to changes in pH and shear forces. The results showed higher PVA molecular weight and alkaline pH conditions increased hydrogel viscosity and stiffness due to a more stable and interconnected network structure than acidic pH. Metoclopramide release revealed that the hydrogels exhibited pH-responsive drug release behavior. The drug was more readily released under acidic conditions due to the instability of sp2-hybridized boronate ester bonds. The influence of shear forces on the release of metoclopramide was also investigated at shear rates of 1, 10, and 100 s-1, revealing their effect on matrix stiffening. The research shows that AlgBA/PVA hydrogels have unique properties, such as dynamic covalent bonding, that make them sensitive to external mechanical forces. This sensitivity makes them ideal for applications where physiological conditions trigger drug release

This multi-center retrospective study evaluated the diagnostic performance of a deep learning (DL)-based application for detecting, classifying, and highlighting suspected aortic dissections (ADs) on chest and thoraco-abdominal CT angiography (CTA) scans. CTA scans from over 200 U.S. and European cities acquired on 52 scanner models from 6 manufacturers were retrospectively collected and processed by CINA-CHEST (AD) (Avicenna.AI, La Ciotat, France) device. The di-agnostic performance of the device was compared with the ground truth established by the majority agreement of three US board-certified radiologists. Furthermore, the DL-algorithm's time-to-notification was evaluated to demonstrate clinical effectiveness. The study included 1,303 CTAs (mean age 58.8 ± 16.4 years old, 46.7% male, 10.5% positive). The device demonstrated a sensitivity of 94.2% [95% CI: 88.8% – 97.5%] and a specificity of 97.3% [95% CI: 96.2% - 98.1%]. The application classified positive cases by AD types with an accuracy of 99.5% [95% CI: 98.9% – 99.8%] for type A and 97.5 [95% CI: 96.4% – 98.3%] for type B. The application did not miss any type A cases. The device flagged 32 cases incorrectly, primarily due to acquisition artefacts and aortic pathologies mimicking AD. The mean time to process and notify of potential AD cases was 27.9 ± 8.7 seconds. This deep learning-based application demonstrated strong performance in detecting and classifying aortic dissection cases, potentially enabling faster triage of these urgent cases in clinical settings.

Gender-based violence (GBV) is an age-long issue plaguing societies all over the globe. Over the years, GBV perpetrated against women has been justified and legitimized by patriarchal and hegemonic masculine structures. This study explored the role of hegemonic masculinities and transnational cultural conflicts in creating a suitable environment for GBV against women to thrive amongst African immigrants in Canada, gathering perspectives of African immigrants and of the service providers working in immigrant-serving organizations. The paper adopts a qualita-tive approach and is hinged on the transnationalism framework. This framework argues that im-migrants maintain connections while transitioning to their countries of destinations. In such pro-cesses, immigrants carry with them their beliefs about cultural norms and hegemonic masculinity, of their country of origin. A total of 13 women immigrants and 20 service providers were pur-posively recruited to participate in the semi-structured interview. The interviews were recorded and transcribed verbatim. The data were analysed thematically and organized using the Nvivo version 12. Findings show that African immigrant women in Canada continue to disproportion-ately bear the burden of GBV due hegemonic masculinities. The construction of masculinity in immigrant population is heavily reliant on the communities of origin. As such, the prevailing sys-tems during and post migration such as – unstable residency status, fear of deportation, fear of social and family sanctions and stigmatization, economic dependence on their spouses, and fear of retaliation from their spouses creates an environment that supports toxic masculinity. The study recommends a comprehensive and culturally sensitive programs and services to support African immigrants affected by hegemonic masculinity and GBV.

: Optical coherence tomography is a non-invasive imaging technique that provides three-dimensional visualization of subsurface tissue structures. OCT has been proposed and explored in literature as a tool to assess oral cancer status, select biopsy sites, or identify surgical margins. Our endoscopic OCT device can generate widefield (centimeters long) imaging of lesions at any location in the oral cavity – but it is challenging for raters to quantitatively assess and score large volumes of data. Leveraging a previously developed epithelial segmentation network, this work develops quantifiable biomarkers that provide direct measurements of tissue properties in three-dimensions. We hypothesize that features related to morphology, tissue attenuation, and contrast between tissue layers will be able to provide a quantitative assessment of disease status (dysplasia through carcinoma). This work retrospectively assesses seven biomarkers on a lesion-contralateral matched OCT dataset of lateral and ventral tongue (40 patients, 70 sites). Epithelial depth and loss of epithelial-stromal boundary visualization provide the strongest discrimination between disease states. The stroma optical attenuation coefficient provides distinction of benign lesions from dysplasia and carcinoma. The stratification biomarkers visualize subsurface changes which provides potential for future utility in biopsy site selection or treatment margin delineation.

This qualitative study explores the intricacies of building sustainable supplier relationships in the e-commerce sector, focusing on best practices and strategic approaches. Through in-depth interviews with procurement managers, supply chain experts, and supplier representatives, the research identifies four critical themes: trust, technology integration, ethical practices, and performance measurement. Trust is found to be the foundation of effective supplier relationships, fostering open communication and collaboration, which are essential for addressing challenges and co-creating solutions. The integration of digital technologies such as supply chain management software, blockchain, and the Internet of Things significantly enhances transparency, decision-making, and operational efficiency, providing a competitive edge. Ethical practices, including adherence to fair labor standards and environmental sustainability, are increasingly crucial as consumer and regulatory expectations evolve, necessitating alignment between e-commerce companies and their suppliers. Performance measurement and continuous improvement are vital for maintaining quality and efficiency, with clear metrics and regular evaluations driving constructive feedback and optimization of supply chain processes. The study underscores the interdependence of these elements in fostering resilient and adaptable supplier relationships. The findings offer practical guidance for e-commerce businesses and suppliers, emphasizing the need for a holistic approach to supplier management that balances trust, technology, ethics, and performance. This approach not only enhances operational effectiveness but also ensures the long-term sustainability of supplier relationships in the dynamic e-commerce landscape. The research contributes to the theoretical understanding of supplier relationship management, providing a comprehensive framework for future studies and practical applications in the e-commerce industry.

Under the action of cement hydration heat, construction environment, thermal insulation measures, and pipe cooling system, the mass concrete pile cap produces a complex temperature field inside the structure, which makes it difficult to control the internal surface temperature difference, the maximum adiabatic temperature rise and the surface temperature of the structure. In this paper, the mass concrete pile cap of a super large bridge (the length, width, and height are 26.40m，20.90m, and 5.00m, respectively, and the central pier pile cap is constructed with concrete with a strength of C40) is taken as the research support project. The controlling factors affecting the temperature field of the mass concrete pile cap are found by comparing the temperature monitoring of the pile cap with the calculated value of finite element software simulation analysis. Through the finite element software Midas Civil and Midas FEA, the control factors affecting the temperature field of the main pier cap (concrete mold temperature, concrete surface convection coefficient, ambient temperature, and pipe cooling system parameters, etc.) are numerically analyzed, and the influence law and influence degree of the control factors are found out.

Background: Hepatitis B virus (HBV), a lethal form of viral hapatitis, is an extra burden on the socioeconomic status of a country. Objectives: The population-based studies to quantify the incidence of hepatitis B. Data sources: in the North Waziristan, formally known as EX-FATA (Federal Administrated Tribal Area), Pakistan, are still rare. Study eligibility criteria: 943 individuals were selected on the basis of signs and symptoms to determine the epidemiology of HBV in the study population. Tests: Hepatitis B virus (HBV). Methods of data synthesis: Among these, 626 were male and 317 were female. All the HBV suspected individual were screened through ICT (Indirect Coombs Test) , ELISA (enzyme-linked immunosorbent assay) and RT-PCR (Re-verse transcription polymerase chain reaction). Results: The results obtained from the screening tests for HBV revealed that RT-PCR based results are more reliable and it indicated that HBV infection is more common in male 41 (6.54%) than female 15 (4.73%). The age range selected for the study was 1-75 years. Age wise analysis indicated that HBV is more prevalent among individuals of age group between 16 to 45 years. This age range also showed higher number of patients having either mild, moderate or elevated viral loads. The HBV genotype D was the most common, present in 62.5% patients. However, 16.07 % patients were having genotype U, 12.5 % genotype C, 8.92 % genotype A, and 7.14% had genotype B. Discussion: The questionnaire based investigation revealed that HBV was most prevalent among married individuals (64.6%), whereas least prevalent among individuals having HBV positive family member (1.4 %). The other risk factors contributed were history of dental procedures (57.8%), ear, nose, piercing, or tattooing and uses of un-disposable syringes (56.5%), transfusion of blood or plasma (42.9%), surgery (41.8%), frequent visits to barber shops (39.45%), and addiction of injectable drugs (38.1%). The current study is providing a clear picture of the alarming situation HBV transmission and emphasis on the need for more effective planing, strategies and policies for the control and prevention of HBV.

This study investigates the influence of pyrolysis temperature on the main properties of BSG (brewer's spent grain) biochar and evaluates its suitability as an energy vector and as a substrate component. Pyrolysis tests were carried out at 673, 773, and 873 K. Bioenergy indexes were calculated for BSG and its biochar, and germination tests were carried out to obtain lentil sprouts. The results showed that the BSG biochar obtained at the lowest temperature biochar presented the best performance for use as biofuel. Regarding the germination tests, the different biochars were applied at 4 doses, and the evaluated parameters such as germination percentage, germination rate, mean germination time, and seed vigor were strongly influenced by the biochar addition. The biochar at 773 K added at a dose of 5% doubled the values of mean germination time, seed vigor, and time for 50% of the seeds to emerge compared to the control, constituted only with distilled water. The sustainable BSG valorization through pyrolysis reduces waste and contributes to circular economy practices by transforming industrial by-products into valuable resources for energy and agriculture. This approach highlights the importance of sustainability in reducing the environmental impact of industrial waste and promoting renewable energy sources.

The present study analyzes students' weather-related hazard and risk literacy in Greece, a climate change hotspot region in the Eastern Mediterranean. In this context, we examine the students' level in two core literacy variables, namely knowledge and competency. In addition, we explore how knowledge, attitudes and socio-demographic variables influence students' competencies related to weather and climate risk assessment and adaptability. A questionnaire-based survey was conducted on 474 students aged 12-16. The regression results showed that knowledge significantly affects the level of competency. Self-belief and confidence in science were the most influential among the attitudinal variables. We conclude by discussing educational and behavioural issues highlighted as essential to address with targeted policies and measures in formal education complemented by non-formal educational activities.

Pseudomonas aeruginosa is an opportunistic pathogen that requires iron to survive in the host; however, the host immune system limits the availability of iron. Pyochelin (PCH) is a major siderophore produced by P. aeruginosa during infection, which can help P. aeruginosa survive in an iron-restricted environment and cause infection. The infection activity of P. aeruginosa is regulated by the Pseudomonas quinolone signal (PQS) quorum-sensing system. The system uses 2-heptyl-3-hydroxy-4-quinolone (PQS) or its precursor, 2-heptyl-4-quinolone (HHQ), as the signal molecule. PQS can control specific life processes such as mediating quorum sensing, cytotoxicity, and iron acquisition. This review summarizes the biosynthesis of PCH and PQS, the shared transport system of PCH and PQS, and the regulatory relationship between PCH and PQS. The correlation between the PQS and PCH is emphasized to provide a new direction for future research.

The philosophy of Industry 5.0 recognizes the transformative power of the industrial sector to add value to society and employees. Industry 5.0, distinct from its predecessors, relies on a tripod of sustainability, human-centric, and resilience. These three thematic principles aim to improve work safety, research and innovation, and strengthen industrial resilience and competitiveness. The potential for positive change is immense. However, a perfect storm is brewing for the future of work, brought about by the concerning trends of displacement and low skill levels of work-ers' competencies in handling the new technologies of Industry 5.0 in emerging economies. This paper will discuss Industry 5.0 and provide historical insights on the importance of acquiring the desired twenty-first-century competencies needed in the workforce for Industry 5.0. Two research questions guided the study in identifying these twenty-first-century competencies, how these com-petencies can be cultivated and taught in the education curriculum and policies of emerging economies, and the crucial im-portance of adapting Industry 5.0 to these emerging economies. The study concluded that emerging economies must play an active role in shaping the future, by creating policies that will advance social stability, resource preservation, and climate objec-tives, which will enable more productive production processes with lower waste and energy usage.

This article presents an Internet of Things (IoT)-enabled system meticulously engineered for comprehensive environmental assessment, encompassing air quality, temperature, and humidity. Simultaneously, the devised system integrates cutting-edge MQ6 sensors, adept at detecting ambient gases, with a primary focus on monitoring Liquefied Petroleum Gas (LPG) and Butane gases concentrations in the atmosphere. This distinctive feature not only facilitates the identifi-cation of hazardous gases leakages, particularly common in household LPG usage, but also empowers preemptive measures. The environmental parameters, air quality, temperature, and humidity, are precisely gauged through the utilization of MQ135 and DHT11 sensors. The con-trolling and managing of the hardware component of the system (i.e., device) is assured by an Arduino UNO, that orchestrates the collection of sensor data, transmitting it seamlessly to both the ThingSpeak cloud and a Convolutional Neural Network (CNN) model. By interfacing with ThingSpeak, the device ensures the systematic storage and visualization of environmental data, streamlining monitoring and analysis processes. In the event of perilous gases detection, the system promptly triggers an alarm, concurrently dispatching a real-time notification to the device owner via the integrated If-This-Then-That (IFTTT) application programming interface (API). To further enrich environmental awareness, an embedded microphone captures audio recordings, subsequently processed by a CNN-based deep learning model. This model employs advanced techniques such as spectrogram generation, Convolution2D, and MaxPooling2D within a Se-quential Model architecture, to attain elevated levels of accuracy, furnishing insightful interpre-tations of ongoing activities within the environment.

Considerable research on intergroup relations emphasizes attitudes, motivations, and emotions that lead to reduction of prejudice. While factors that actively promote positive intergroup interactions have been emerging, a central theoretical framework has not been formally proposed. To address this gap, we engage a positive psychology lens to explore how and why people overcome their internalized biases to seek out successful and positive intergroup relations, looking to the positive counterparts of traditional prejudice-reduction models to begin building a framework of understanding. We reviewed the literature on values that guide intergroup behavior. After scanning 16,840 records that emerged in PsycInfo using keywords “egalitarian,” “non-prejudice,” and “intergroup,” we assessed 158 articles for eligibility. Among the relevant articles (N = 54), we analyzed authors’ definitions, methods of measurement, types of processes, and outcomes associated with egalitarian and non-prejudice values as they related to intergroup behavior. Overall, there was notable variability in how researchers conceptualized and observed egalitarianism. We discuss the five broad categories of egalitarianism (prejudice reduction, positive expression, concern for others, low social-dominance orientation, and universal orientation) and how they relate to positive or negative, and approach or avoidant outcomes. We propose a centralized model for studying positive values in intergroup contexts moving forward.

Lanthanides and actinides are emerging contaminants, but little is known about their uptake and distribution by plants and their interactions in the rhizosphere. To better understand the fate of these metals in plants, we assessed the bioassociation of 2, 20 and 200 µM Eu(III) by five hydroponically grown crops endemic to Europe. The metal’s concentration and its speciation was monitored by inductively coupled plasma mass spectrometry and laser spectroscopy, whereas root exudation was investigated by chromatographic methods. It has been shown, that Eu(III) bioassociation is a two-stage process, involving rapid biosorption followed by accumulation in root tissue and distribution to the stem and leaves. Within 96 h of exposure time, the plant induces a change of Eu(III) speciation in the liquid medium, from a predominant Eu(III) aquo species, as calculated by thermodynamic modelling, to a species with longer luminescence lifetime. Root exudates such as citric, malic, and fumaric acid were identified in the cultivation medium and affect Eu(III) speciation in solution, as was shown by a change in the thermodynamic model. These results contribute to a comprehensive understanding of the fate of lanthanides in the biosphere and provide a basis for further investigations with the chemical analogues Cm(III) and Am(III).

Lithium-ion batteries have gained immense popularity in electric vehicles(EVs) due to their high energy density, offering an extended driving range. This has made them the preferred choice in the automotive industry, driving the shift towards EVs. However, alongside their popularity, safety concerns have arisen. The main issues include the potential for thermal runaway leading to fires or explosions, which can occur due to overcharging, physical damage, or manufacturing defects. While safety features and rigorous testing aim to mitigate these risks, ongoing research and development focus on enhancing safety measures to further ensure the reliability and safety of lithium-ion batteries in EVs. This paper focuses on the development and deployment of a real-time monitoring dashboard for Li-ion battery health monitoring using STM32 Microcontroller within the framework of Industry 4.0. Leveraging advanced sensor technology and data analytics, the dashboard provides continuous, comprehensive insights into battery performance, including state of charge and temperature. Integrating with Industry 4.0 principles, such as IoT, the system enables predictive maintenance, optimizing production processes and ensuring efficient utilization of resources. The implementation showcases the integration of real-time monitoring tools for Li-ion batteries, aligning with the transformative paradigms of Industry 4.0 to enhance operational efficiency and reliability within industrial settings.

This research focuses on developing a Student Performance Evaluation System to enhance effectiveness and oversight in higher education. The system aims to address challenges faced by instructors in evaluating student performance using a distributed system approach. Agile methodology is employed in development, and database replication techniques are applied for data synchronization. System features include registration, assessment form creation, assessment submission, statistical visualization, and access to assessment history. The system is designed to improve efficiency and transparency in the assessment process. Key features of the system include registration process, assessment form creation, assessment submission, statistical visualization, and access to assessment history. Its goal is to enhance efficiency and transparency throughout the assessment process. The article details the system workflow and the roles played by Admins, Instructors, and students in system usage. Additionally, it discusses the back-end development model and pathways, as well as the performance testing results. Performance testing indicates that the system achieves high throughput of up to 21.55 requests per second, with an average response time of only 34 milliseconds and an error rate of zero percent. These results affirm that the system efficiently handles user loads and nearly instantaneously responds to requests, providing an optimal user experience in the context of student performance evaluation in higher education.

This study analyzed the dynamic spatial and temporal distribution of natural disasters in Traditional Authorities Ngabu and Lundu in Chikwawa District in the Lower Shire Valley. The study assessed the vulnerability of people to disasters, evaluated the value of losses and damages incurred when disasters strike and to locate disaster hotspots. The mixed design that embraces qualitative and quantitative approaches was used. Data collection methods such as in-depth interviews, Focus Group Discussion, documentary review, structured interview and Participatory Geographical Information Systems (P-GIS) were employed. The study revealed that farming with 64%, 37% and 76% done before, during and after disasters respectively, was the main adaptive capacity to floods and drought in T/A Ngabu. In T/A Lundu, community members also valued farming with 58%, 55% and 70% done before, during and after disasters respectively. The study found that Traditional Environmental Knowledge Systems (TEKS) were highly valued in T/As Ngabu with 90% and Lundu 81%. The study also unveiled those disasters led to losses of human lives and livestock and damages to properties, environment and critical infrastructures. However, some community members still remained in the disaster-prone areas for farming, fishing, protecting the chieftaincy and ancestral reasons. The study also showed that CBDRM was highly adopted. However, disasters continued to occur and losses were increasing. Generally, CBDRM could be effective through multisectoral approach and good legal institutional framework. Therefore, the research recommends that further studies similar to this, should use GIS in assessing the efficacy of CBDRM approaches to produce hazard maps that will be used as models for disaster risk reduction in Chikwawa District in the Lower Shire Valley.

During the 3rd millennium cal BC, the Indus communities exploited great quantities of chert from the Rohri Hills mines in Upper Sindh for making different types of artefacts. This paper discusses the way chert was transported to the Indus Civilization centres and the problems related to the type, quantity and quality of raw material and artefacts that were transported, when, why, and where. This paper raises the question of land and water transport. Both these methods were probably used according to the landscape location of the Indus sites. Another problem regards the landscape characteristics of the Indus Valley during the Bronze Age before the climate changes which took place around the end of the 3rd millennium cal BC, and the disappearance of the Hakra River, which was an important watercourse during the Indus phase. What do we know of the way the Indus communities exploited, transported, and circulated knappable chert? Why the Indus settlements excavated around the Rohri Hills, the largest chert mines of the Indian Subcontinent, have yielded little evidence of chert artefacts and nodules? What do we know of this important problem which is strictly related with the everyday life of the Indus communities and their economy? Why this problem has been systematically neglected by most archaeologists despite its importance?

Infrared and visible light image fusion technology integrates image feature information from two different modalities to generate an image that integrates complementary information from the source images. However, in low-light scenarios, the degradation of lighting in visible light images leads to existing fusion methods being unable to effectively extract texture detail information from the scene. At this time, the target prominence information provided by infrared images alone is far from sufficient. To address this challenge, this paper proposes a lightweight infrared and visible light image fusion method based on low-light enhancement, named LLE-Fuse. Firstly, the method improves the MobileOne Block by embedding the Sobel operator in the Edge-MobileOne Block to perform feature extraction and downsampling on the source images. Then, intermediate features of different scales are obtained and fused through a cross-modal attention fusion module, followed by image reconstruction using a decoder with upsampling. Next, the CLAHE algorithm is used for image enhancement of infrared and visible light images, and the enhanced loss guides the network model to learn the capability of low-light enhancement. Finally, upon completion of the network training, the method optimizes the Edge-MobileOne Block into the direct connection structure of MobileNetV1 through structural re-parameterization, effectively reducing the computational resource consumption of the model network. Through extensive experimental comparisons, this paper's method demonstrates excellent performance in both visual appeal and evaluation metrics, providing satisfactory fusion results even in low-light scenarios.

We sequenced and assembled genomes for 17 isolates of Staphylococcus cohnii isolated from osteomyelitis lesions in young broilers from two separate experiments where we induced lameness using a hybrid wire-litter flooring system. Whole genome comparisons using three different methods support a close relationship of genomes from both S. cohnii and Staphylococcus urealyticus. The data support three different lineages, we designated Lineage 1, Lineage 2 and Lineage 3, uniting these two species within an evolving complex. We present evidence for horizontal transfer between lineages of genomic regions from 50-440 kbp. The transfer of a 186 kbp region from Lineage 1 to Lineage 2 appears to have generated Lineage 3. Human-associated isolates appear to be limited to Lineages 2 and 3 but Lineage 2 appears to contain a higher number of human pathogenic isolates. The chicken isolates from our lameness trials included genomically diverse isolates from both Lineage 1 and 2, and isolates from both lineages were obtained from osteomyelitis lesions of individual birds. Our results expand the diversity of Staphylococci associated with osteomyelitis in poultry and suggest a high diversity in the microbiome of day-old chicks. Our data also support a reevaluation and unification of the taxonomic classifications of S. cohnii and S. urealyticus.

Aim: To determine the prevalence of skeletal muscle alterations (SMA) in patients with meta-bolic dysfunction-associated steatotic liver disease (MASLD) and to assess the significance of circulating myokines as potential biomarkers of SMA in patients with MASLD. Material and methods: Measurements of both skeletal muscle strength and skeletal muscle mass parameters, anthropometric and metabolic features as well as serum levels of different myokines were per-formed in a cohort of 62 MASLD patients and then compared according to the stage of liver fi-brosis and hepatosteatosis degree both diagnosed by transitional elastography. Results: No sig-nificant differences were found in skeletal muscle strength and skeletal muscle mass in MASLD patients stratified according to the stage of liver fibrosis. Noteworthy, serum levels of FGF21 were significantly higher in MASLD patients with advanced hepatic fibrosis (F3-F4) than in those with lower stages of hepatic fibrosis (F0-F2) (197.49±198.27 pg/ml vs 95.62±83.67 pg/ml, p=0.049, respectively). MASLD patients with severe hepatosteatosis (S3) had significantly higher serum levels of irisin (1116.87±1161.86 pg/ml) than those with lower grades (S1-S2) (385.21±375.98 pg/ml, p=0.001). Conclusion: SMA were uncommon in our MASLD patients, particularly in those with lower stages of liver fibrosis. An increase in serum FGF21 was detected in patients with a higher stage of fibrosis with possible therapeutic implications in MASLD.

This qualitative study explores the relationship between supply chain responsiveness (SCR) and customer loyalty within the e-commerce sector. E-commerce has revolutionized global commerce, driven by technological advancements and shifting consumer behaviors. Central to e-commerce success is the ability to meet customer expectations swiftly and reliably, necessitating agile supply chain management (SCM) practices. SCR in e-commerce encompasses the capacity to adapt to dynamic market demands, minimize disruptions, and enhance customer satisfaction through efficient logistics, inventory management, and last-mile delivery. Through in-depth interviews with customers, e-commerce platform managers, and supply chain practitioners, this study investigates key themes, challenges, strategies, and impacts associated with SCR and customer loyalty. Findings reveal that customers prioritize fast order fulfillment, reliable service quality, personalized experiences, and trustworthy interactions, all of which significantly influence their loyalty and advocacy behaviors. Challenges identified include inventory management complexities, logistical hurdles in last-mile delivery, and the need for effective supplier communication. Strategic approaches to enhance SCR include leveraging data analytics for demand forecasting, adopting agile SCM practices, integrating customer feedback into service improvements, and fostering collaborative relationships with suppliers. These strategies not only optimize operational efficiency but also cultivate enduring customer relationships based on satisfaction, trust, and loyalty. The study concludes that improved SCR practices lead to increased customer satisfaction, repeat purchases, and positive word-of-mouth, thereby strengthening competitive advantage and sustainability in the e-commerce marketplace.

Numerous investigations have suggested that seismic source parameters and properties of the surrounding medium harbor valuable information regarding alterations in stress fields and medium properties at the focal depth. Monitoring the spatial and temporal evolution of these parameters can yield insights into variations in stress fields or medium properties within the seismogenic zone, offering a critical avenue to overcome the Earth's inaccessible nature. In recent years, modern seismic parameters such as seismic moment, focal mechanism solution, source stress drop, corner frequency, radiated seismic energy, rupture radius, and apparent stress have been increasingly used to characterize source characteristics. The Sichuan region is situated on the southeastern edge of the Qinghai-Tibet Plateau and is known for its strong eastward extrusion and structural deformation. The main fault zones in the area include the Xianshuihe Fault, Anninghe Zemuhe Fault, and Longmenshan Fault. This paper estimates source parameters of small to medium-sized earthquakes (ML 1.5-5.2) in the main fault zones and adjacent areas in Sichuan. A total of 4,310 earthquake stress drop measurements from 2019 to 2023 were analyzed to create a stress distribution image along the fault. This earthquake parameters training catalog provides insight into how coseismic stresses change and their relationship with other geophysical factors, as well as their spatial and temporal evolution.

Background. Coronary artery disease (CAD) with extensive stenosis presents significant clinical challenges. This case report details the management and outcomes of a 61-year-old male with a notable history of CAD, initially treated with coronary artery bypass grafting (CABG), followed by an innovative intravenous hydrogen and oxygen nanobubble therapy due to recurrent symptoms.Case Presentation. Mr. BH was diagnosed with significant stenosis in the left anterior descending (LAD) artery and left circumflex (LCx) artery, initially managed by CABG. Recurring symptoms led to the adoption of a novel treatment involving hydrogen and oxygen nanobubbles. Following treatment initiation, Mr. BH experienced substantial improvements in physical capacity and symptomatic relief, with an ability to climb 22 flights of stairs and resolution of previous symptoms such as dyspnea and cough. Despite these improvements, subsequent imaging revealed in-stent restenosis and progression of graft disease.Discussion. The application of hydrogen and oxygen nanobubbles as a therapy in CAD is explored, highlighting potential mechanisms such as reduction of oxidative stress and improvement in endothelial function. This case contrasts the effects of conventional surgical and pharmaceutical interventions with the novel nanobubble therapy, illustrating both the benefits and complexities of managing advanced CAD with innovative treatments.Conclusion. While Mr. BH showed clinical improvement with nanobubble therapy, the development of new severe stenosis and restenosis underscores the need for further research to understand the long-term efficacy and mechanisms of nanobubble therapy in complex CAD cases. This case suggests that while innovative therapies may provide symptomatic relief and functional improvement, they do not obviate the need for ongoing surveillance and possibly further intervention.

Green and sustainable electrocatalytic conversion of nitrogen-containing compounds to ammonia are currently in high demand in order to replace the eco-unfriendly Haber-Bosch process. Model catalysts for the nitrate reduction reaction were obtained by electrodeposition of metal Co, Fe and bimetallic Fe/Co nanoparticles from aqueous solutions onto a graphite substrate. The samples were characterized by the following methods: SEM, XRD, XPS, UV-vis spectroscopy, cyclic (and linear) voltammetry, chronoamperometry and electrochemical impedance spectroscopy. Besides, the determination of electrochemically active surface was also performed for all electrocatalysts. The best electrocatalyst was a sample containing Fe-nanoparticles on the layer of Co-nanoparticles, which showed the Faradaic efficiency 58.2% (E=-0.785 V vs. RHE) at the ammonia yield rate of 14.6 μmol h-1 cm-2. An opinion was expressed on elucidation of the mechanism of coordinated electrocatalytic action of a bimetallic electrocatalyst. This work can serve primarily as a starting point for future investigations on electrocatalytic conversion reactions to ammonia using model catalysts of the proposed type.

Background: Gait analysis systems offer invaluable insights for rehabilitation, yet their expense limits clinician access. We developed GAITWell®, a low-cost modular system for capturing spatiotemporal gait variables, and evaluated its measurement properties. Methods: The GAITWell® uses discreet binary sensors on interconnected boards to collect gait data, which is then analyzed using the DBSCAN algorithm on the Cartesian points from sensor outputs. Reliability was assessed using ICC2,1, standard error of the mean (SEM) and Bland-Altman plots. Validity was determined by comparing GAITWell® with the Qualisys Pro-Reflex system. Results: Participated 38 healthy adults, with an average age of 33.2 years (SD 13.0). Correlations between GAITWell® and the Qualisys system ranged from moderate to very high for most gait variables, with the exception of stride length, which demonstrated a low but significant correlation (r = .360, p < .05). The ICC2,1 indicated moderate to good agreement for most gait variables. Stance and double support times, cadence, and base of support exhibited poor reliability, characterized by larger SEM and limits of agreement. Conclusions: Our findings indicate that the GAITWell® system is a promising tool for gait analysis. Future research will enhance sensor accuracy and refine algorithms to improve reliability.

In recent years, the treatment of locally-advanced rectal cancer (LARC) has been spotlighted in a number of landmark, practice-changing trials, heralding in the age of so-termed “total neoadjuvant therapy” (TNT). However, the lack of a common control arm, standard inclusion criteria, or, indeed, definition of TNT necessitates further study in this field, particularly using real-world data. We conducted a retrospective analysis of all patients treated for LARC at a single Canadian academic cancer centre between July 1st 2019 and July 14th 2022. This includes the June 2020 incorporation of TNT. 290 patients were included in the final analysis, and 124 variables were collected on each patient, including demographics, treatment type, adverse events, response to treatment, surgery versus watchful waiting and survival. Our findings demonstrate that both TNT and non-TNT regimens are highly toxic, with regards to both overall toxicity and grade 2+ adverse effects. 62 (96.9%) of patients on TNT experienced toxicities, compared to 186 (82.3%) of the non-TNT patients. Grade 2+ toxicities were 46 (71.9%) and 143 (63.3%), respectively. TNT, however, was associated with improved rates of complete response, compared to non-TNT treatment regimens (44% vs 24%). These findings suggest that TNT harbours both benefit and risk in a real-world population, and both of these aspects should be considered when deciding on a treatment approach for an individual patient. More work in the area is needed to determine longer term survival, as well as impact of surgery versus organ preservation approach on patient outcomes.

This work investigates into the enhancement of iris recognition systems through a two-module approach focusing on low level image preprocessing techniques and advanced feature extraction. The first module is dedicated to the preprocessing of iris images, leveraging the Canny algorithm for edge detection followed by the circle-based Hough transform for precise iris extraction. This process, integral to our methodology, ensures the quality and consistency necessary for the subsequent Binary Statistical Image Features (BSIF) analysis. The second module employs the BSIF technique, incorporating domain-specific filters trained on iris-specific data, for robust biometric identification. By combining these advanced image preprocessing techniques, the proposed method addresses key challenges in iris recognition, such as occlusions, varying pigmentation, and textural diversity. Experimental results on the Human-inspired Domain-specific Binarized Image Features (HDBIF) Dataset composed of 1892 iris images demonstrate the effectiveness of the developped approach, with potential future improvements including adaptive algorithms and machine learning integrations for enhanced performance in diverse and unpredictable real-world applications. The novel contributions of this paper lie in the provision of a reproducible research framework, making the iris-domain-specific BSIF filters, training patches, testing database, and source codes publicly available for further application and study.

Safety and the apprehension of crime persist as significant concerns in both urban and rural locales. Crime Prevention Through Environmental Design (CPTED) guidelines, an architectural approach to crime deterrence, mitigate the likelihood of criminal activity by implementing strategic defensive design plans, particularly through effective lighting schemes within urban settings, thereby alleviating fear of crime. This comprehensive set of principles serves to enhance overall quality of life. Additionally, within the realm of environmental crime prevention, enhanced street lighting has been identified as a crucial factor in diminishing both actual crime rates and the perceived risk of criminal activity in built environments. While current recommendations advocate for the installation of lighting in poorly lit areas for safety reasons, evaluating visibility solely based on the presence of existing streetlights proves insufficient for analyzing road surface luminance comprehensively. Thus, this study proposes establishing standardized illumination levels specifically tailored for facial recognition of potential criminal offenders. Furthermore, we advocate for defining specific thresholds for color temperature and colorimetric criteria to aid in distinguishing characteristics of individuals' attire. To analyze photometric safety and crime frequency in Seoul, Korea, new primary evaluation indicators were developed, including the Brightness index, Informatization index, and Safety index. By incorporating quantitative data into lighting design strategies, particularly within the framework of CPTED, there exists the potential to mitigate fear of crime during nighttime hours. These strategies facilitate the creation of well-lit environments conducive to the swift recognition and identification of potential perpetrators, thereby presenting a proactive approach to crime prevention. Consequently, this study introduces quantitative lighting standards to augment the efficacy of CPTED guidelines, ultimately contributing to the reduction of crime incidence.

Abstract. Myopia has become a major health problem around the world. The devel-opment of myopia is starting to appear at an earlier age than in previous generations and its consequences have prompted multiple studies, particularly regarding topical atropine treatment aiming at preventing or slowing myopia progression. Our objective is to review randomized and controlled studies on the efficacy and safety of topical atropine to prevent myopia progression in children. This was a narrative review compiled from literature of PubMed and Cochrane Library, including randomized and controlled clinical trials of atropine eye drops for myopia progression published within 2017 - 2023. Fourteen clinical trials were found in the 7 year-period analyzed. All study atropine concentrations were effective in reducing the progression of myopia compared to the placebo. The highest dose of atropine (1%) showed the best efficacy in reducing the spherical equivalent progression and axial elongation over the lower dose (0.01%). Side-effects were mild or moderate. The use of atropine eye drops to prevent myopia progression has shown benefits without involving serious adverse effects. Higher doses of atropine (0.5% and 1%) have been shown to have more efficacy in preventing myopia progression than lower doses (0.01%), so starting intervention with those doses of at-ropine could be considered for preventing myopic children from becoming severe myopia patients later in life.

Nuʻupia Ponds, a traditional Hawaiian fishpond system, are located at Marine Corps Base Hawaii (MCBH) and part of the Nuʻupia Ponds Wildlife Management Area, a wetland refuge for native, endangered, and protected birds and Hawaiian green sea turtles, as well as many native fish species. Currently, there is uncertainty regarding the ecological status and condition of the fishponds following prior modification of wetland habitats in and around the ponds. This study examines circulation dynamics and characterizes water exchange, pond volume, and residence time across the full tidal spectrum at Nuʻupia fishponds. Our results indicate a general west to east gradient in current flow; with higher flushing rates and lower residence times of fishponds in the western ponds of the Nu’upia system compared to the eastern ponds. We further found low flushing rates at several sites causing limited water exchange with Kāne’ohe Bay, as well as within Nu’upia Pond system. Sufficient water circulation plays a fundamental role in maintaining a healthy balance of fishpond flora and fauna and preserve ecosystem health. The results from this study provide a baseline of current physical water circulation dynamics and implications for ecosystem health, as well as inform science-based conservation and management strategies moving forward.

A general consensus is that the conventional linear modalities guarantee no industrial sustenance in long run for many obvious reasons. This is where the topicality of circularity has been accentuated for the last two decades or so in socio-political arena. However, anecdotal evidence suggests that the emphasis given to circularity in the construction industry is relatively low. Tackling this issue essentially warrants a rigorous co-production of integrated knowhow preferably beyond sectorial boundaries. The present study sheds light on interdisciplinary approaches taken to deal with the slowness in transmuting circularity into construction sector. A comprehensive literature survey was undertaken to understand this phenomenon at policy, firm and site level. The analysis included one hundred twenty-eight (128) articles published in high impact journals between 2003 and 2024. Eighty seven (87) gaps in terms of theory, knowledge, practice, method, empiricism and policy were observed. Forty four (44) thematic sub-clusters have the potential of empirical research. A new framework was finally proposed to scaffold the systemic transition towards a circular construction sector. On a practical level, the study offer valuable insights and instruments for the industry personnel to gauge the efficacy of their own circular approaches and initiatives.

This paper presents data supporting the IC Regimen for potentiating the effectiveness of lorlatinib in treating ALK positive cancers, and specifically non-small cell lung cancer. Lorlatinib is an effective treatment for ALK driven non-small cell lung cancer and other ALK driven cancers. Lorlatinib inhibits ALK kinase and achieves good brain tissue levels, a common site for metastases in lung cancers. However, resistance to lorlatinib usually supervenes and the cancer awakens and starts growing again, resistant to lorlatinib. This paper analyses data indicating that adding two common generic drugs, itraconazole and cilostazol, to lorlatinib treatment may delay resistance development. Itraconazole is marketed worldwide as a generic antifungal drug that also inhibits Hedgehog signaling, CYP3A4, and the p-gp efflux pump. Cilostazol is a generic anti-thrombosis, phosphodiesterase 3 inhibiting drug that carries minimal bleeding risk. Cilostazol may enhance lorlatinib by deprivation of trophic growth factors supplied by platelets. Itraconazole may enhance lorlatinib effectiveness by reducing or stopping a Hedgehog centered amplifying feedback loop with ALK kinase. The combination of metastatic non-small cell lung cancer being a low-survival disease and the general safety itraconazole plus cilostazol augmentation, make a clinical trial of this trio worthwhile.

The term immersive technology refers to various types of technologies and perspectives that are constantly changing and developing. It can be used for different purposes and domains such as: education, healthcare, entertainment, arts, and engineering. This research paper aims to examine which training method is more effective between the traditional approach, using PowerPoint and the immersive technology approach, through mixed reality using a HoloLens 2 device. The experiment involves comparing two groups of students who received different training methods: the first group saw a PowerPoint slide with an image of the human muscular system, while the second group saw a 3D hologram of the human body that showed the same muscle groups as in PowerPoint. The researchers wanted to test whether mixed reality devices could enhance students' cognitive functions and to investigate if the IQ of the participants had any influence in the effectiveness of the teaching method. The main finding of this study is that the instructions given with mixed reality technology, via the Microsoft HoloLens 2 device, are more appropriate for participants who have an IQ score below 100 points. For the other participants, with an IQ score above 100 points, the PowerPoint support was more suitable.

A 64-year-old woman with primary Sjogren’s syndrome which was not treated, was admitted to our hospital for nasal bleeding, oral bleeding, and purpura on her entire body. On this admission, laboratory findings were as follows: WBC counts, 8,910 /μL; hemoglobin, 9.9 g/dL; and platelet counts, 0.1×10⁴/μL. Although the anti-PLT antibody was positive, other autoimmune antibodies such as anti-DNA were negative. Moreover, cytomegalovirus IgM, Parbovirus B19 IgM, and Helicobacter pyroli IgG antibodies were not detected. No abnormal findings suggestive of infection were identified in the systemic examination. A bone marrow aspiration smear revealed normal bone marrow. Based on these findings, the patient was diagnosed with primary Sjogren’s syndrome-related immune thrombocytopenia. The patient initially received intravenous immunoglobulin, methyl prednisolone pulse therapy, and subsequent high dose prednisolone without significant improvement. Therefore, eltrombopag, a thrombopoietin-receptor agonist, was added. Subsequently, erythromycin was also added, considering its immunomodulatory effects. After initiating the erythromycin treatment, the platelet counts increased. Therefore, add-on eltrombopag and erythromycin treatment was effective; however, the platelet counts gradually decreased with reducing the prednisolone dosage. Instead of increasing the prednisolone dosage again, tacrolimus, a calcineurin inhibitor, was successfully added. Consequently, the prednisolone dosage could be reduced. This case shows that treatment with erythromycin and tacrolimus may be efficacious when conventional immunosuppressants show limited effectiveness in primary Sjogren’s syndrome-related immune thrombocytopenia.

【Objectives】To elucidate and enhance the impact of nitrogen fertilizer on capsaicin, thus providing guidance on fertilizer application for the cultivation of high spiciness chilli.【Methods】The experiment was conducted with five nitrogen fertilizer concentrations, N1 (urea 750 kg.hm-2), N2 (urea 562.5 kg.hm-2), N3 (urea 375 kg.hm-2), N4 (urea 187.5 kg.hm-2), and N0 (no nitrogen fertilizer). Nitrogen treatment was applied to two varieties with different spiciness from seedling stage, and the fruit was sampled at three fruit developmental periods, and the contents of capsaicin, capsaicin precursors, capsaicin competitive substances, as well as capsaicin related enzyme activities and gene expression were analyzed.【Results】When applying N2 and N3, both types of peppers exhibited higher fruit length, fruit width, and fruit weight, which favored yield increase. Specifically, N2 resulted in varied increases in total phenol, flavonoid, and tannin contents of the two varieties. Moreover, placenta weight and PAL enzyme activity of capsaicin synthase significantly increased, while capsaicin degrading enzyme activities of POD and PPO decreased notably. Additionally, the expression of capsaicin synthetic genes such as PAL, AT3, 4CL, C4H, COMT, PAMT, and HCT was up-regulated in N2-treated fruits, leading to a significantly higher capsaicin content compared to the other four treatments. Further reduction of nitrogen application to N3 and N4 resulted in decreased precursor substance total phenol content and PAL activity, increased competitive substance flavonoid, lignin, POD and PPO enzyme activities, at the same time, the expression levels of capsaicinoid synthetic genes were down-regulated in N3, N4 treatments, which lead to an reduction in total capsaicinoid content. During fruit development, the capsaicinoid content showed a trend of 35 d > 50 d > 20 d for both varieties. Additionally, the contents of total capsaicinoid, total phenol, flavonoid, and lignin, as well as PAL enzyme activity and the expression of PAL, AT3, 4CL, C4H, COMT, PAMT, and HCT of the fruit, exhibited characteristics of lower layer > middle layer > upper layer. Furthermore, the activities of capsaicinoid degrading enzymes POD and PPO gradually increased from bottom to top.【Conclusions】The N2 (562.5 kg.hm-2) treatment resulted increases of placenta mass, maximum precursor substance total phenol content and synthase enzyme activity, and decreases of competing substances and degradative enzyme activity, resulting in more substances being available for capsaicin synthesis. Combined with the higher fruit weight in the N2 treatment, N2 was therefore considered to be a suitable nitrogen fertilizer dosage for high spiciness chilli cultivation.

In this paper, we investigate the so-called electronic dressed states, a unified quasiparticle resulting from the interaction between electrons in a two-dimensional material with an off-resonance optical dressing field. If the frequency of this field is much larger than all characteristic energies in the system, such as the Fermi energy or bandgap(s), the electronic band structure is affected by radiation so that some important properties of the electron dispersions could be modified in a way desirable for practical applications. For example, a circularly polarized light can be used to vary the bandgap of Dirac materials: it opens a gap in graphene and other metallic and semimetallic lattices, or modifies the magnitude of an existing gap. This will either enhance or reduce a gap, depending on its initial value as well as properties of a host material. Here, we consider gaped dice and Lieb lattices as samples, and put forward a full theoretical model to reveal how these electronic states are deformed by an elliptically-polarized irradiation with a focus on generation and modification of a bandgap.

A hallmark of eutherian pregnancy is its dependency on elevated progesterone levels for its entire length. This fact substantially affected the evolution of pregnancy and even the life history of eutherians. Progesterone synthesis by the ovarian corpus luteum, however, long predates all origins of vertebrate viviparity, which requires reconsidering the role of the corpus luteum and progesterone before and beyond placental mammals. Pregnancy originated repeatedly by co-opting the ancestral luteal phase of the ovarian cycle. Therefore, it represents a physiological equivalent and “serial homolog” of the nonpregnant luteal phase. Because of this relationship, we argue that understanding the origin and evolution of pregnancy can substantially benefit from examining the evolution and regulation of the corpus luteum during nonpregnancy. In the first part of this paper, we investigate what is known about the evolution of the corpus luteum and its changing regulation and function across vertebrates, covering both pregnant and nonpregnant cycles wherever possible. Studying pregnancy in the context of the nonpregnant cycle reveals the key evolutionary innovation that facilitated the characteristically long eutherian pregnancies: the regulatory decoupling of the pregnant and nonpregnant cycle, that is, the evolution of maternal recognition of pregnancy. Only after the two cycles became separately modifiable, could gestation length increase without deleteriously extending the time to the next fertile phase. In this review, we argue that, assuming selection for body size increase, the origin of MRP led to a punctuated increase of gestation length, which could imply that we overestimate pregnancy length in the eutherian ancestor when using conventional phylogenetic inference methods. Mechanistically, decoupling between cycles means that the progesterone-dominated phase in pregnancy is extended beyond that of nonpregnancy. In eutherians, this is achieved by extending the lifespan of progesterone-producing corpus luteum, providing additional corpora lutea, extraovarian sources of progesterone, or a combination of these. Alternatively, it can also be accomplished by shortening the nonpregnant cycle. The differences in underlying mechanisms for decoupling among the major eutherian lineages suggest that they originated independently, which leads us to conclude that eutherian gestation consists of parts that are not homologous across eutherians. Consequently, eutherian gestation length is not a homologous trait that can be productively compared across species directly. Finally, we find no evidence for an increase in gestational length due to maternal-fetal conflict. Rather, as long appreciated, body size explains a major portion of the variation in gestation length in eutherians. This suggests that the increase in eutherian gestation length was driven by the need to accommodate an increasing body size, a well-documented trend (Cope’s rule), once independent evolution of pregnant and non-pregnant cycles became possible.

A methodology for selecting rational parameters of atmospheric aircrafts at the initial stages of design using an optimization algorithm of differential evolution and numerical mathematical modeling of aerodynamics problems is proposed. The technique involves the implementation of weight and aerodynamic balance in the main flight modes, has the ability to consider atmospheric aircrafts with one or two lifting surfaces, apply parallel calculations and automatically generate a three-dimensional geometric model of aircraft appearance based on the optimization results. A method for accelerating the process of optimizing the parameters of an aircraft in terms of take-off weight by more than three times by introducing a objective function into a set of design variables is proposed and demonstrated. The results of assessing the reliability of the used mathematical models of aerodynamics and the correctness of the calculation the objective function, taking into account various constraints, are presented. A comprehensive test of the performance and efficiency of the methodology is considered by solving demonstration problems to optimize more than ten main design parameters the appearance of two existing heavy-class unmanned aerial vehicles with known characteristics from open sources.

Recent advancements in cognitive neuroscience, particularly in Electroencephalogram (EEG) signal processing, image generation, and brain-computer interfaces (BCI), have opened up new avenues for research. This study introduces a novel framework, Bridging Artificial Intelligence and Neurological Signals (BRAINS), which leverages the power of AI to extract meaningful information from EEG signals and generate images. The BRAINS framework addresses the limitations of traditional EEG analysis techniques, which struggle with nonstationary signals, spectral estimation, and noise sensitivity. Instead, BRAINS employs Long Short-Term Memory (LSTM) networks and contrastive learning, which effectively handle time-series EEG data and recognize intrinsic connections and patterns. The study utilizes the MNIST dataset of handwritten digits as stimuli in EEG experiments, allowing for diverse yet controlled stimuli. The data collected is then processed through an LSTM-based network employing contrastive learning and extracting complex features from EEG data. These features are fed into an image generator model, producing images as close to the original stimuli as possible. This study demonstrates the potential of integrating AI and EEG technology, offering promising implications for the future of brain-computer interfaces.

This study introduces an innovative approach to designing membranes capable of separating CO2 from industrial gas streams at higher temperatures. The novel membrane design seeks to leverage the well-researched high-temperature CO2 adsorbent, hydrotalcite, by transforming it into a membrane. This is achieved by combining it with an amorphous organo-silica-based matrix, extending the polymer-based Mixed Matrix Membrane concept to inorganic compounds. Following the membrane material preparation and investigation of the individual membrane in Part 1 of this study, we examine its permeation and selectivity here. The pure 200 nm thick hydrotalcite membrane exhibits Knudsen behavior due to large intercrystalline pores. In contrast, the organo-silica membrane demonstrates a permselectivity of 13.5 and permeance for CO2 of 1.3 107 mol m2 s1 Pa1 at 25°C, at 150°C the good separation behavior is reduced. Combining both components results in a hybrid microstructure, featuring selective surface diffusion in the microporous regions and unselective Knudsen diffusion in the mesoporous regions. Further attempts to bridge both components to form a purely microporous microstructure are outlined.

This study describes the synthesis and characterization of mixed hydrotalcite–organosilica membrane for gas separation. Hydrotalcite exhibits the capability to adsorb carbon dioxide at elevated temperatures. High surface area and favorable coating properties are essential to harness its potential for practical applications. Stable alcohol-based dispersions are needed for thin film applications of mixed membranes containing hydrotalcite. Currently, producing such dispersions without the need for delamination and dispersion agents is a challenging task. This work introduces for the first time a manufacturing approach to overcoming the drawbacks mentioned above. It includes a synthesis of hydrotalcite nanoparticles, followed by agent-free delamination of their layers and final dispersion into alcohol without dispersion agents. Further, the hydrotalcite-derived sorption agent is dispersed in a matrix based on organo-silica gels derived from 1,2-bis(triethoxysilyl)ethane (BTESE). The analytical results indicate that the interconnection between hydrotalcite and BTESE-derived gel occurs via forming a strong hydrogen bonding system between the interlayer species (OH groups, CO32-) of hydrotalcite and oxygen and silanol active gel centers. These findings lay the foundation for applications involving incorporating hydrotalcite-like compounds into silica matrices, ultimately enabling the development of materials with exceptional mass transfer properties. In part 2 of this study, gas separation performance of the organo-silica and the hydrotalcite-like materials and their combined form will be investigated

Terpenes and terpenoids content in cannabis plant was already studied in the past with three used methods. Since these works did not compare the content of these substances under the same conditions, we tried to make this comparison exactly. Three different gas chromatography/mass spectrometry (GS/MS) methods - hexane based liquid extraction (Liq), static head-space extraction (HS), and head-space solid phase microextraction (SPME) – were compared to identify volatile compounds in four different cannabis chemotypes - Green fields, Titan chemotype, Black Domina chemotype, and Neptune chemotype. The main compounds focused on were monoterpenes/monoterpenoids and sesquiterpenes/sesquiterpenoids. Extraction with hexane gave comparable results, however the other two methods allowed for the identification of more substances. For the final evaluation of the comparison of the three methods of analysis, extraction with hexane gives comparable results (which is advantageous for quantitative analysis), although the other two methods allowed for the identification of more substances. This means that the same method should be used everywhere for the quantitative evaluation of constituents in cannabis.

Background: The objectives were to evaluate: the safety and immunogenicity of nonavalent human papillomavirus (nHPV) vaccine in adult Spanish women living with HIV (WLHIV); the prevalence of anal and cervical dysplasia and nHPV vaccine genotypes in anus and cervix; and risk factors for high-risk HPV (HR-HPV) infection in anal mucosa. Methods In this single-center, open-arm, non-randomized clinical trial, nHPV vaccine was administered at 0, 2, and 6 months to WLHIV enrolled between February 2020 and November 2023, measuring vaccine antibody titers pre-vaccination and at 2, 6, and 7 months after the first dose. Cervical and anal cytology and HPV PCR genotyping studies were performed. Women with abnormal cytology and/or anal or cervical HPV infection at baseline underwent high-resolution anoscopy and/or colposcopy. Results: 122 participants were included with mean age of 49.6 years: 52.5% smoked; 10.7% had anal-genital condylomatosis; 38.5% infection by HR-HPV in anus and 25.4% in cervix, most frequently HPV-16; 19.1% had AIN1 and 3.1% CIN1 and CIN2. Vaccine administration did not modify viral-immunological status (CD4 [809±226.8 cells/uL vs. 792.35 ±349.95; p=0.357]) or plasma HIV load (3.38±4.41 vs. 1.62±2.55 cop/uL [log]; p=0.125). Anti-HPV antibodies ([IQR: 0-0] vs. 7.63 nm [IQR: 3.46-19.7]; p=0.0001) and seroconversion rate (8.2% vs. 96.7% [p=0.0001]) were increased at 7 versus 0 months. There were no severe vaccine-related adverse reactions; injection-site pain was reported by around half of participants. HR-HPV infection in anus was solely associated with concomitant cervix infection (HR 5.027; 95% CI: 1.009-25.042). Conclusions: nHPV vaccine in adult WLHIV is immunogenic and safe.

Civil construction is one of the oldest known activities in humanity, reports indicate that builders of the Roman Empire already sought the reuse of materials. Currently, considering the depletion of the supply of natural resources, the recycling of solid waste from construction and demolition (CDW), not only provides new products, but also offers ecological and economic alternative. In this context, this research seeks new variables for the disposal of waste from construction and demolition having in the composition of artificial finishing stones an odd possibility to be analyzed. In this research was developed and analyzed a new composite from the construction and demolition waste using as a binder an orthophthalic polyester resin. The residue was sieved and separated by granulometry by the simplex centroid method, the best compacted mixture was determined statically by ANOVA and the Tukey test. The residue was characterized by X-ray fluorescence and the resin by infrared spectroscopy by Fourier transform. Artificial rock plates were produced with 85% residue and 15% resin, by mass, by vibro system, compression and vacuum, later were cut for mechanical, physical and chemical tests. Analysis was performed by scanning electron microscopy of fractured compositions as well as grain sizes. The artificial stone with the best results presented density of 2,256 g/cm3, water absorption of 0.69%, apparent porosity of 1.55%; bending strength of 34.74 MPa and compression of 111.96 MPa; good results in the alterability and thermal tests. In this satisfactory scenario, the use of this waste in the composition of artificial rocks is promising because it directly meets the concept of sustainable development; replacing the concept of end-of-life of the linear economy, by new circular flows of reuse, restoration and renovation, in an integrated process the circular economy; as well as the quality of the final product with properties similar to the artificial rocks already marketed.

This study investigated different conditions for the hydrothermal co-liquefaction (co-HTL) of sugarcane bagasse and residual cooking soybean oil, with and without the presence of ethanol as a cosolvent to maximize the bio-crude yield. All co-HTL reactions were carried out in a 300 mL Parr® reactor at temperatures ranging from 200 to 300 °C. Bio-crude yields of around 95 wt.% were obtained at 300 °C using ethanol and water as solvents. The highest biochar yield (16.6 wt.%) was achieved when using only sugarcane bagasse as substrate, without the presence of soybean oil. Bio-crude samples obtained at higher temperatures (280 °C and 300 °C) using ethanol as a hydrogen donor presented higher contents of both free fatty acids and fatty acid ethyl esters. This work presents a promising process to produce high-quality bio-crude using an abundant feedstock (sugarcane bagasse) in the presence of a lipid source which could cause environmental problems if poorly handled.

Background: Worldwide, around 73 million induced abortions take place every year. Of these, 45% are unsafe and can lead to complications. The evolution of the legal and practical landscape of abortion in the Democratic Republic of the Congo (DRC) over the last few years necessitates a re-examination of the experience of induced abortion, leading this study to measure the incidence of abortion among young women (15 to 29 years of age), as well as the heterogeneity of this problem according to the residence of these young women (slum vs. non-slum areas). Methodology: We used representative survey data on women aged 15–49 in Kinshasa, collected from December 2021 to April 2022. The survey included questions about the respondents’ and their closest confidants’ experience of induced abortion, including the methods and sources used. We estimated abortion incidence and heterogeneity over one year based on residence in the city of Kinshasa according to sociodemographic characteristics. Results: The incidence rate of induced abortion among the confidants (close friends) in 2021 was 131.5 per 1000 (95% CI: IQR 99.4–163.6). These rates were significantly higher than the corresponding estimates of those surveyed. The incidence of induced abortion was 24.4 per 1000 (95% CI: 15.8–32.9) abortions per 1000 women among the respondents. The incidence rates of induced abortion were much higher among the respondents residing in slums than among those residing in non-slums (29.2 vs. 13.0 per 1000; p < 0.001). Conclusions: More precise estimates of the incidence of abortion indicate that the incidence rate of abortion was higher among young women residing in slums, who were unmarried and had no children. These incidences were higher among confidants than among respondents. There is still a lot of work to be done to fulfill the obligations outlined in the Maputo Protocol. This includes establishing easily accessible services that offer complete abortion care with a focus on women's needs, particularly in slum areas. The aim is to decrease the occurrence of unsafe abortions and their associated effects.

Ticks are one of the most dominant forced ectoparasites of vertebrates, belonging to the arthropods, which transmit pathogens such as bacteria, viruses, and parasites to humans and animals in Iran and worldwide. Given that, sex ratio factors can affect the epidemiology of vector-borne diseases, this study aimed to identify and determine the ticks' sex ratio and host type (camels, sheep, cattle, dogs, chickens, and pigeons) in different areas of Tehran province. This descriptive cross-sectional study took samples from different animal body parts in four seasons from 20 villages in 2019, in which 685 hard ticks and 121 soft ticks were caught from 1623 studied livestock and poultry. Regarding sex segregation among all caught ticks, 42.01% were male, and 57.99% were female. It is noteworthy that in both mountain and plain environments, R. sanguineus species of hard ticks had the most elevated sex ratio. Most ticks were collected from sheep hosts with 60.04% and the lowest from cattle hosts with 0.62% in tick infestation.

More than 20 lines of independent evidence from clinical observations, studies in laboratory animal models, pharmacokinetic considerations, and numerous temporal and spatial associations previously indicate that numerous genetic and environmental factors leading to inflammation and oxidative stress confer vulnerability to aberrant metabolism of acetaminophen during early development, leading to autism spectrum disorder (ASD). Contrary to this conclusion, multivariate analyses of cohort data adjusting for inflammation-associated factors have tended to show little to no risk of acetaminophen use for neurodevelopment. To resolve this discrepancy, here we use in-silico methods to create an ideal (virtual) population of 120000 individuals in which 50% of all cases of virtual ASD are induced by oxidative stress-associated cofactors and acetaminophen use. We demonstrate that Cox regression analysis of this ideal data set shows little to no risk of acetaminophen use if cofactors which create aberrant metabolism of acetaminophen are adjusted for in the analysis. Further, under-reporting of acetaminophen use is shown to be a considerable problem for this analysis, leading to large and erroneously low calculated risks of acetaminophen use. In addition, we argue that factors which impart susceptibility to acetaminophen-induced injury, and propensity for acetaminophen use itself, can be shared between the prepartum, peripartum, and postpartum periods, creating additional difficulty in analysis of existing datasets to determine risks of acetaminophen exposure for neurodevelopment during a specific time frame. It is concluded that risks of acetaminophen use for neurodevelopment obtained from multivariate analysis of cohort data depend on underlying assumptions in the analyses, and that other evidence, both abundant and robust, demonstrate the critical role of acetaminophen in the etiology of ASD.

This study explores the role of stakeholder engagement in enhancing supply chain sustainability within the renewable energy sector. Through a qualitative research approach, including in-depth interviews with key stakeholders such as government agencies, industry associations, renewable energy companies, community groups, and environmental organizations, the research reveals the complexity and significance of effective stakeholder engagement. Stakeholders highlighted diverse motivations, including environmental, social, economic, and regulatory concerns, driving their participation. The study underscores the importance of tailored engagement strategies that recognize stakeholder heterogeneity and address specific needs and expectations. Collaborative approaches, such as public-private partnerships and multi-stakeholder initiatives, were identified as crucial for pooling resources, sharing knowledge, and addressing common challenges. However, challenges related to power imbalances, conflicting interests, and communication barriers were also noted. Government policies and regulatory frameworks were found to play a pivotal role in shaping stakeholder engagement practices and sustainability outcomes. Regulatory uncertainty and inconsistency were cited as significant concerns that could undermine sustainability initiatives. Community engagement emerged as a critical factor, with local communities often directly impacted by renewable energy projects. Meaningful engagement, including consultation and benefit-sharing mechanisms, is essential for building trust and securing social acceptance. Emotional intelligence and marketing strategies were recognized as important tools for effective stakeholder engagement, emphasizing the role of empathy, active listening, and clear communication. The findings of this study highlight the need for a holistic and integrated approach to stakeholder engagement and supply chain sustainability in the renewable energy sector. By addressing diverse stakeholder needs, fostering collaboration, and aligning policies with sustainability goals, stakeholders can work together to accelerate the transition towards a more sustainable energy future.

A class of semi-linear elliptic equations with critical Hardy-Sobolev exponent has been considered. This model is widely used in hydrodynamics and glaciology, gas combustion in thermodynamics, quantum field theory and statistical mechanics, as well as gravity balance problems in galaxies. The $\left( PS\right) _{c}$ sequence of energy functional has been investigated, and then the mountain pass lemma was used to prove the existence of at least one nontrivial solution. Also a multiplicity result has been obtained. Some known results have been generalized.

Recent studies have shown that the endogenous cannabinoid system (ECS) of the brain is essentially involved in the pathogenesis of Parkinson's disease (PD), influencing its symptoms by regulating the level of endogenous cannabinoids and altering the activation of cannabinoid receptors (CBR). Therefore, modulation of ECS with new drugs developed for this purpose may prove to be a promising strategy in the treatment of PD. However, fine regulation of ECS is quite a challenge due to the functional diversity of CBR in the basal ganglia. Our review analyses the effects of ECS modulators on experimental PD models and in patients with PD, as well as presents the outlooks for the development of new cannabinoid drugs for the treatment of motor and non-motor symptoms in PD.

There are clear signs that the COVID-19 pandemic has had a straining impact on the higher education sector in South Africa and the far reaches of the world. This chapter examines (Science, Technology, Engineering, Mathematics) STEM lecturers’ experiences with digital assessments and perspectives on the continuity of digital transformation in the higher education sector in the post-COVID-19 era at one of South Africa’s rural universities. In 2022, a survey of ten (10) lecturers was conducted and the reports were also consulted by four (4) e-learning practitioners to obtain their views on the use of online learning and contact courses in the post-pandemic period. A qualitative research approach was used to understand the puzzling issues faced by STEM lecturers at a previously disadvantaged institution in Limpopo Province. The results of this study show that there is a puzzling conundrum that hinders the integration of effective online learning. Furthermore, online education as the new normal in the post-COVID-19 era seems unattainable due to extremely complex and difficult-to-understand mathematical symbols. Software and tools proved to be limitations in terms of establishing an interactive learning environment for students and lecturers on online learning platforms. Lecturers’ use of learning and teaching platforms deteriorated due to numerous unknown challenges, but also the tightening of COVID-19 restrictions. Furthermore, the results showed that science and mathematics lecturers believe that contact learning remains irreplaceable across generations and eras as some are not technology enthusiasts. This paper recommends that the lack of technological systems as well as technological resistance and reluctance to adopt transformative pedagogy and innovative practices, should not be viewed as a thorny issue to end the dominance of online education in STEM courses. Keywords: connectivism, Learning Management Systems, affordances, technological resistance, Moodle, transformative pedagogy

This paper presents a novel segmentation algorithm specially developed for applications in 3D point clouds with high variability and noise, particularly suitable for heritage building 3D data. The method can be categorized within the segmentation procedures based on edge detection. In addition, it uses a graph-based topo-logical structure generated from the supervoxelization of the 3D point clouds, which is used to make the clo-sure of the edge points and to define the different segments. The algorithm provides a valuable tool for generating results that can be used in subsequent classification tasks and broader computer applications dealing with 3D point clouds. One of the characteristics of this segmentation method is that it is unsupervised, which makes it particularly advantageous for heritage applications where labelled data is scarce. It is also easily adaptable to different edge point detection and supervoxelization algorithms. Finally, the results show that the 3D data can be segmented into different architectural elements, which is important for further classification or recognition. Extensive testing on real data from historic buildings demonstrates the effectiveness of the method. The results show superior performance compared to three other segmentation methods, both globally and in the segmentation of planar and curved zones of historic buildings.

The production of Moringa oleifera capsules has emerged as a promising agricultural activity in Mexico, driven by the plant’s well-documented health and nutritional benefits. In response, farmers have begun producing Moringa oleifera as a dietary supplement, using artisanal methods with minimal production controls. This study aimed to estimate the processing times of the Moringa oleifera production system using simulation modeling with Arena® software, and to evaluate the economic feasibility of capsule production. Methodologically, it was approached as a case study in the state of Veracruz, processing times were estimated through systematic sampling and modeled with Arena simulation software. Three simulation scenarios were considered to select a technically and economically viable alternative for agricultural producers: one with a 200-capsule encapsulator (1E200C), another with two 200-capsule encapsulators (2E200C) and a third with an 800-capsule encapsulator (1E800C). For the initial diagnosis a research stay was conducted for 180 days, and the production capacity was set at 24,000 capsules due to raw material limitations. Results indicated that the 1E800C scenario reduced processing time by 60% compared to the1E200C scenario, and by 35% compared to the 2E200C scenario. Additionally, the 1E800C model required only 2 days (16 hours) of work, while the 2E200C required 4 days (32 hours), and the 1E200C required 7 days (56 hours). In terms of production costs per unit of 90 capsules, the 1E200C was 3.93 USD the 2E200C 3.64 USD and the 1E800C 3.45 USD The study concluded that due to raw material limitations, the company can produce 12,800 units per year of 90 capsules. It is recommended to adopt the 1E800C encapsulator, which would lower overall production costs by 12.23%, representing 0.48 USD per unit produced, resulting in an additional profit of 6,150.50 USD Over a five-year evaluation period, the benefit-cost ratio was 5.03, the NPV was 922,370.11 and the IRR was 42.09%, indicating that this type of agribusiness in Mexico is both technically and economically feasible.

This article critically examines existing wastewater management legislation, highlighting its detrimental impact on environmental and public health. It emphasizes the urgent need for a mentality shift among water managers, advocating responsible stewardship of water resources. By promoting collaboration between regulatory bodies and scientific communities, the article seeks tailored solutions for complex challenges. It underscores the necessity of integrating technological innovation, rigorous monitoring, and public engagement for sustainable management. Additionally, it calls for the implementation of easy-to-adopt technological solutions, alongside rigorous monitoring and financial support. Ultimately, the article advocates for a paradigm shift in wastewater management policies towards accountability, innovation, and environmental sustainability. Directives governing wastewater management in Europe, particularly in Spain, have faced scrutiny due to significant shortcomings. Legislation has inadvertently facilitated untreated or poorly treated wastewater discharge, resulting in widespread pollution. Despite EU efforts, punitive measures have proven ineffective, with fines often borne by the public sector, although private sector responsibility. The lack of robust monitoring mechanisms and technical support exacerbates the situation, perpetuating a regressive mindset among water managers. Urgent reforms are needed to enforce strict discharge prohibitions, promote reuse, and provide financial and technical assistance. However, systemic barriers and entrenched mentalities pose formidable challenges to meaningful change.

: Cytokine storm is usually described as one of the main reasons behind COVID-associated mor-tality. Cytokines are essential protein molecules engaged in immune responses; they play a critical role in protection against infections. However, they also contribute to inflammatory reactions and tissue damage, becoming a double-edged sword in the context of COVID-19. Recent studies have suggested various cytokines and chemokines that play a crucial role in the immune response to SARS-CoV-2 infection. One such cytokine is Interleukin 27 (IL-27), which has been found to be elevated in the blood plasma of patients with COVID-19. Within this study, we will explore the role of IL-27 in immune responses and address our own findings concerning this cytokine in COVID-19. It affects a wide variety of immune cells; regardless of the pathological process it is involved in, IL-27 is critical for upholding the necessary balance between tissue damage and cytotoxicity against in-fectious agents and/or tumors. In COVID-19, it is involved in multiple processes, including antiviral cytotoxicity via CD8+ cells, IgG subclass switching, and even the activation of Tregs.

Knowledge of local plant community characteristics is imperative for practical nature planning and management, and for understanding plant diversity and distribution drivers. Today, retrieving such data is only possible by fieldwork and is hence costly both in time and money. Here we used 9 bands from multispectral high-to-medium resolution (10–60 m) satellite data (Sentinel-2) and machine learning to predict the local vegetation plot characteristics at broad extent (approx. 30.000 km2) in terms of plants’ preferences for soil moisture, soil fertility, and pH, mirroring the levels of the corresponding actual soil factors. These factors are believed to be among the most important for local plant community composition. Our results showed that there are clear links between the Sentinel-2 data and plants abiotic soil preferences and using solely satellite data we achieved predictive powers between 26–59% improving to about 70% when habitat information was included as a predictor. This show that plants abiotic soil preferences can be detected quite well from space, but also that retrieving soil characteristics using satellites is complicated and that perfect detection of soil conditions using remote sensing – if at all possible – needs further methodological and data development.

In this study, using information theory tools, we investigate the quantum degree of mixedness, particle number fluctuations, and temperature variations in the paradigmatic Lipkin model, focusing on the interplay between these factors in a system of many fermions. Our analysis reveals intriguing dependencies of quantum mixedness on the total fermion number, showcasing distinct behaviors at different temperatures. Notably, we find that the degree of quantum mixedness exhibits a strong dependence on the total fermion number, with varying trends observed across different temperature regimes. Remarkably, this dependence remains unaffected by the strength of the fermion-fermion interaction (if it does not vanish, of course), underscoring the robustness of the observed phenomena. Through comprehensive numerical simulations, we provide illustrative graphs that depict these dependencies, offering valuable insights into the fundamental characteristics of many-fermion systems. Our findings shed light on the intricate dynamics of quantum degree of mixedness and particle number fluctuations in fermionic systems, with potential implications for diverse fields ranging from condensed matter physics to quantum information science.

Deploying onshore wind energy as a cornerstone of future global energy systems challenges societies and decision-makers worldwide. Expanding wind energy should contribute to a more sustainable electricity generation without harnessing humans and their environment. Opponents often highlight the negative environmental impacts of wind energy to impede its expansion. This study reviews 152 studies to synthesize, summarize, and discuss critically the current knowledge, research gaps, and mitigation strategies on the environmental impacts of onshore wind energy. The investigated effects comprise impacts on the abiotic and biotic environment, with birds and bats in particular, noise and visual impacts. Effects are discussed in the context of social acceptance, other energy technologies, and wind energy expansion in forests. The review illustrates that many effects are highly case-specific and must be more generalizable. Studies are biased regarding the research focus and areas, needing more standardized research methods and long-term measurements. Most studies focus on the direct mortality of birds and bats at wind farms and are concentrated in Europe and North America. Knowledge gaps persist for many impact categories, and the efficacy of mitigation strategies has yet to be proven. More targeted, unbiased research is required that allows for an objective evaluation of the environmental impacts of wind energy and strategies to mitigate them. Impacts, such as those on biodiversity, need to be addressed in the context of other anthropogenic influences and the benefits of wind energy. This forms the basis for a socially acceptable, efficient, and sustainable expansion of wind energy.

Any Geiger counter can be used as an effective cosmic ray detector on its own. In fact, it is known that even in the absence of a radioactive source, the instrument detects what is known as background radiation, which consists of various types of ionizing particles present in the environment. Remarkably, it is estimated that up to 15% of this background radiation is attributable to cosmic rays, high-energy particles originating from outer space. The remaining radiation detected by the Geiger counter originates from terrestrial sources, such as natural radioactivity in the ground and in the air. The main goal of this project is to build a muon detector for scientific and educational purposes using two commercial DIY Geiger counter kits and just a few additional components. To identify cosmic radiation from terrestrial radiation and improve the accuracy of cosmic ray measurements, the use of a coincident circuit is essential. This coincident circuit was introduced in cosmic ray physics by Walther Bothe and Bruno Rossi in the early 1930s and allows for the detection of a subatomic particle passing through two or more sensors, thereby reducing false positives and enhancing the reliability of cosmic ray detection.The following idea is an alternative to our AMD5 detectors, instruments that we have been using for years to teach and perform scientific experiments in the cosmic ray field under the umbrella of the ADA project (2023 Particles, Arcani et al.). The resulting device offers a reliable and cheap solution for the same goal, making it a valuable tool for both educational purposes and even scientific surveys.

Vinyltriethoxysilane (VTES) was covalently bonded onto graphene oxide. Several methods, including X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, and X-ray diffraction, were used to demonstrate the presence of VTES on the surface of graphene oxide and the creation of this covalent link. Following that, different quantities of the resultant vinyltriethoxysilane functionalized graphene oxide (VTESFGO) were mixed with polyvinyl alcohol (PVA) to form VTESFGO/PVA nanocomposite films (NCFs) with a 3-dimensional network structure. The creation of these NCFs and the presence of a three-dimensional network were confirmed by Fourier transform infrared spectroscopy. The three-dimensional network structure provided these NCFs extraordinary characteristics. The mechanical and thermal stability, oxygen transfer rate (OTR), and water resistance pressure (WRP) of the NCFs were investigated. The nanocomposite film (NCF) with the highest weight percentage of VTESFGO (3.0 wt.%) was 47.5% more thermally stable than pure PVA, with an oxygen transmission rate of 0.3 cm3/m2 per day and a water resistance pressure of 780 mm/cm2. However, as the weight percentage of VTESFGO increased, the mechanical strength of the NCFs decreased as a result of silanol self-condensation, resulting in particulate formation, as confirmed by scanning electron microscopy.

In the intricate landscape of software development, the distinction between average and exceptional outcomes often hinges on the approach taken by the engineers involved. This paper explores the core aspects that characterize responsible and professional software engineering, emphasizing the importance of stakeholder engagement, innovative problem-solving, and adherence to standards and best practices. Through detailed real-life examples, we illustrate how professional engineers ensure the creation of robust, efficient, and adaptable software solutions. Additionally, the paper delves into advanced strategies for enhancing database security, including the implementation of Sealed Secrets in Kubernetes environments, continuous improvement, and future enhancements. The goal is to provide a comprehensive understanding of professional software engineering practices and their impact on delivering superior value to projects and organizations.

Staphylococcus aureus bacteremia continues to be associated with significant morbidity and mortality, despite improvements in diagnostics and management. Persistent infections pose a major challenge to clinicians and have been consistently shown to increase the risk of mortality and other infectious complications. S. aureus, while typically not considered an intracellular pathogen, has been proven to utilize an intracellular niche, through several phenotypes including small colony variants, as a means for survival that has been linked to chronic, persistent, and recurrent infections. This intracellular persistence allows for protection from the host immune system and leads to reduced antibiotic efficacy through a variety of mechanisms. These include antimicrobial resistance, tolerance, and/or persistence in S. aureus that contribute to persistent bacteremia. This review will discuss the challenges associated with treating these complicated infections and the various methods that S. aureus uses to persist within the intracellular space.