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Preprint HYPOTHESIS | doi:10.20944/preprints202305.1129.v1

Lymphatics — Future Perspectives Unrealized Potential

Philip David Houck, Hari function and Dandapantula, Janet Massey

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Lymphangiontrope; salt sensitivity; cardiorenal syndrome; SGLT2 inhibitors; Down’s syndrome; depression; schizophrenia; C Reactive Protein

Online: 16 May 2023 (08:51:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0441.v1

Knowledge Map of Digital Learning and Sustainable Development (2004-2022): a Scientometric Analysis by Using Citespace

Youhua Shen, Lehui Huang, And Xueshi Wu

Subject: Social Sciences, Education Keywords: digital learning; CiteSpace; visualization; Web of Science

Online: 29 July 2022 (02:48:11 CEST)

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Working Paper ARTICLE

Sol-gel Synthesis and Characterization of a Quaternary Bioglass for Bone Regeneration and Tissue Engineering

Ricardo Bento, Anuraag Gaddam, and José M. F. Ferreira

Subject: Chemistry And Materials Science, Biomaterials Keywords: Bioactive glasses; Alkali-free; Sol-gel; Bone regeneration; Tissue engineering.

Online: 1 July 2021 (11:20:51 CEST)

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In bone tissue engineering, ceramics have been the choice due to their excellent biological properties. But the paradigm changed with the discovery of bioactive glasses (BGs) in 1969 by Larry Hench and co-workers, due to their ability to bond to living tissues through the formation of an interfacial bone-like hydroxyapatite layer when the bioglass was put in contact with biological fluids in vivo. Among a number of tested compositions, the one exhibiting the highest bioactivity index is the well-known trademarked 45S5 Bioglass®. The topic received increasing attention particularly after 1985 when this material entered in the market of biomedical devices, inspiring many other investigations aiming at further exploring the in vitro and in vivo performances of this BG, or developing other related BG compositions. The research efforts gradually revealed a number of shortcomings of 45S5 Bioglass®, mostly derived from its high sodium content, initially intended to decrease the melting temperature and accelerating the degradation of the silicate network over time. But the extensive release of sodium from 45S5 Bioglass® in the biological fluids creates a high pH cytotoxic environment. Other serious drawbacks include a fast degradation rate, and a poor sintering ability, which hinders the reliable fabrication of porous scaffolds. Therefore, sol-gel was regarded as an attractive alternative to prepare alkali-free BG compositions. The process uses inorganic and/or organic precursors, which undergo hydrolysis and condensation at room-temperature, being less costly. When properly conducted, the sol-gel process might result in amorphous structures with all the components intimately mixed at the atomic scale. Moreover, developing new better performing materials for bone tissue engineering is a growing concern, as the ageing of the world’s population leads to lower bone density and osteoporosis. This work describes the sol-gel synthesis of a novel quaternary silicate-based BG with the composition 60 SiO2 – 34 CaO – 4 MgO – 2 P2O5 (mol%) was prepared using acidified distilled water as single solvent. By controlling the kinetics of the hydrolysis and condensation steps, an amorphous glass structure could be obtained. The results of XRD of samples calcined within the temperature range from 600-900 ºC demonstrated that amorphous nature was maintained until 800 ºC, followed by partial crystallization at 900 ºC. The specific surface area, an important factor in osteoconduction, was also evaluated over different temperatures, ranging from 160.6 ± 0.8 m2/g at 600 ºC down to 2.2 ± 0.1 m2/g at 900 ºC, being accompanied consistent changes in average pore size and agreeing pore size distribution. The immersion of the BG particles in simulated body fluid (SBF) led to the formation of an extensive apatite layer on its surface. These overall results indicate the proposed material is very promising for biomedical applications in bone regeneration and tissue engineering.

Preprint ARTICLE | doi:10.20944/preprints202011.0340.v1

Analysis of Impact Characteristics and Detection of Internal Defects for Unidirectional Carbon Composites with Respect to Fiber Orientation

Sun-ho Go, Alexandre Tugirumubano, and Hong-gun Kim

Subject: Chemistry And Materials Science, Biomaterials Keywords: drop-weight impact; unidirectional carbon composites; orientation angle; internal defect; impact

Online: 12 November 2020 (10:16:23 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202010.0070.v1

Feeding and Pore Formation in Semisolid Metal Casting

Anders E. W. Jarfors, Qing Zhang, and Stefan Jonsson

Subject: Chemistry And Materials Science, Biomaterials Keywords: Semisolid casting; porosity, hydrogen, shrinkage, feeding; stirring; degassing

Online: 5 October 2020 (11:03:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0585.v1

Defect Depth Estimation in Infrared Thermography with Deep Learning

Qiang Fang, Farima Abdolahi Mamoudan, and Xavier. Maldague

Subject: Engineering, Automotive Engineering Keywords: NDT Methods; Defects depth estimation; Pulsed thermography; Gated Recurrent Units

Online: 26 August 2020 (12:29:30 CEST)

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Preprint ESSAY | doi:10.20944/preprints201701.0056.v1

The Implementation of Green Infrastructure: Relating a General Concept to Context and Site

Gunilla Lindholm

Subject: Social Sciences, Urban Studies And Planning Keywords: green infrastructure; sustainable urban development; urban planning; landscape representations

Online: 11 January 2017 (07:44:52 CET)

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Preprint REVIEW | doi:10.20944/preprints201610.0097.v1

Windings of Planar Processes and Applications to the Pricing of Asian Options

Stavros Vakeroudis

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: planar Brownian motion; complex-valued Ornstein-Uhlenbeck processes; Lévy~processes; Stable processes; windings; skew-product representation; Spitzer's Theorem; Bougerol's identity; Asian options; pricing

Online: 24 October 2016 (04:57:32 CEST)

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Preprint DATA DESCRIPTOR | doi:10.20944/preprints201608.0191.v1

688,112 Statistical Results: Content Mining Psychology Articles for Statistical Test Results

Chris H. J. Hartgerink

Subject: Social Sciences, Behavior Sciences Keywords: nhst; p-values; apa; content mining; tdm; errors

Online: 23 August 2016 (10:33:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0184.v1

Effect of Temperature and Molarity on the Evaluation of Antimicrobial, Cytotoxic, and Antioxidant Activities of the Bio-Oil from Açaí Seed (Euterpe oleracea, Mart.)

Iago Castro da Silva, Pamela Suelen da Silva Seabra, Kely Campos Navegantes Lima, Ricardo Barbosa Bezerra Filho, Alanna Lorena P. dos Santos, Amanda Caroline dos Santos Monteiro, Giovanna Quintero Pamplona, Alexandre Guilherme da Silva Dias, Rayane Caroline dos Santos Pereira, Leticia Araujo Costa, Thays Jhessica Mota Pinheiro, Lauro Henrique Hamoy Guerreiro, Nélio Teixeira Machado, Marta Chagas Monteiro

Subject: Medicine And Pharmacology, Pharmacy Keywords: Açaí; Bio-oil; Pyrolysis

Online: 2 August 2024 (16:44:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1518.v1

Changes of Periodontal Parameters and Microbiome Composition of Tooth Pocket in Patients with Chronic Inflammatory Diseases Receiving Targeted Anti-Cytokine Therapy

Juliane Wagner, Luisa Haker, Louisa Mewes, Corinna Bang, Malte Rühlemann, Hendrik Naujokat, Johannes Heinrich Spille, Wolfgang Lieb, André Franke, Stefan Schreiber, Matthias Laudes, Christof Dörfer, Jörg Wiltfang, Christian Graetz, Dominik Maria Schulte

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: chronic inflammation; periodontitis; microbiome; anti-cytokine therapy

Online: 26 March 2024 (11:03:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.1980.v1

Enhanced Outer Membrane Vesicle Production in Escherichia coli: from Metabolic Network Model to Designed Strain Lipidomic Profile

Héctor Alejandro Ruiz-Moreno, Juan Daniel Valderrama-Rincon, Monica Patricia Cala, Miguel Fernández-Niño, Andrés Fernando Gonzalez Barrios

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Outer Membrane Vesicles; Lipidomics; CRISPR; Metabolic Network Models; E. coli JC8031

Online: 25 September 2024 (12:15:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1918.v1

Stable Microclimates and Autonomic Modulation in Horses Sin-Gle-Stall Housed in Different Stable Architectures During Mon-Soon in a Tropical Savannah Environment

Chanoknun Poochipakorn, Kanokpan Sanigavatee, Kansuda Leelehapongsathon, Thita Wonghanchao, Metha Chanda

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Air velocity; Humidity; Interior environment; Monsoon; Noxious gases; Single-stall housing; Stress responses; Temperature; Tropical savannah climate; Welfare

Online: 24 September 2024 (14:06:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1224.v1

Translation, Cultural Adaptation of the Portuguese Provider Attitudes toward Cardiac Rehabilitation and Referral (PACRR-P) Scale and Assessment of its’ Measurement Properties

Mayara Moura Alves da Cruz, Luiz Carlos Marques Vanderlei, Carolina Takarashi, Maria Julia Lopez Laurino, Murilo Reis Alves da Cruz, Sherry L Grace, Gabriela L M Ghisi

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Attitudes; Cardiac rehabilitation; Health knowledge; Physician’ s practice patterns; Practice; Questionnaires

Online: 16 September 2024 (12:29:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0349.v1

Evaluation of a Point of Care Gem Premier ChemSTAT Analyzer in Emergency Department: Prevention of Contrast-Induced Nephropathy and Optimization of Patient Flow

Marina Brailova, Marie Audin, Julien Raconnat, Jean-Baptiste Bouillon-Minois, Jeannot Schmidt, Bruno Pereira, Damien Bouvier, Vincent Sapin

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: contrast media; creatinine; contrast-induced nephropathy; point-of-care; ChemSTAT; emergency

Online: 4 September 2024 (11:24:04 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202409.0141.v1

Successful Resolution of Cervical Insufficiency after Administration of a Novel Triple Antibiotic Therapy: A Case Report

Serena Xodo, Bassma Benchick, Ginevra Battello, Giovanni Baccarini, Marta Angelini, Maria Orsaria, Lorenza Driul

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: Cervical insufficiency; triple antibiotic therapy; cerclage; intra-amniotic infection; case report

Online: 3 September 2024 (11:21:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1609.v1

Expression Profiling of Coding and Noncoding RNAs in the Endometrium of Patients with Endometriosis

Mi Ran Choi, Hye Jin Chang, Jeong-Hyeon Heo, Sun Hyung Yum, Eunae Jo, Miran Kim, Sang-Rae Lee

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Endometriosis; endometrium; menstrual cycle; long noncoding RNA; neighboring gene

Online: 23 August 2024 (10:12:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1305.v1

Comorbidity Burden among Adults with Symptomatic COVID-19 Illness: A Cross-Sectional Study

Mini M. Jose, Juan Feng, Bushra Manakkat, Hoang Nguyen, Josie Tombrella, Patricia Savard, Hanaa S. Sallam, Hani Serag

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: COVID-19 positive adults; Charlson Comorbidity Index; Comorbidity burden and COVID-19; Depression and COVID-19; Comorbidities and COVID-19; Social determinants of COVID-19

Online: 19 August 2024 (10:05:29 CEST)

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Preprint ESSAY | doi:10.20944/preprints202408.1079.v1

Overexpression of EuSIP5 Gene to Improve Drought Resistance in Tobacco

Yue-Ling Lin, Xi Chen, De-Gang Zhao, Chao Li

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: E. ulmoides; EuSIP5; transgenic; tobacco; drought resistance

Online: 15 August 2024 (12:19:08 CEST)

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Soluble inorganic pyrophosphatase (sPPase), a pyrophosphate hydrolase, has been shown to play an important role in several physiological processes such as plant growth and development, metabolic activities, and response to abiotic stresses, but sPPase has been less studied in woody plants. In order to preliminarily verify whether the soluble inorganic pyrophosphatase in Eucommia ulmoides Oliver (E. ulmoides) has a role in resistance to drought stress, we amplified the EuSIP5 (E. ulmoides soluble inorganic pyrophosphatase 5) cDNA sequence from E. ulmoides by RT-PCR. In order to study the drought resistance of the Eucommia ulmoides soluble inorganic pyrophosphatase 5 (EuSIP5) gene, the cDNA sequence of the EuSIP5 gene was amplified from Eucommia ulmoides Oliver by RT-PCR. Bioinformatic analysis indicated that EuSIP5 might be an unstable amphipathic protein, mainly located in the cytoplasm. E. ulmoides, the highest expression of the EuSIP5 gene was found in male leaves and pericarp from April to October, and in leaves of E. ulmoides in July and September. During drought, the expression of EuSIP5 in seedling E. ulmoides leaves was significantly higher than that of the control. An overexpression vector harboring the EuSIP5 was constructed and introduced into the tobacco (Nicotiana tabacum cv. Xanthi). We found that during drought stress, the appearance of wilting was delayed by 4 days in transgenic tobacco plants (OE) compared with wild type plants (WT), and the expression of drought-related genes DET2, CYP85A1, P5CS, ERF1 and F-box was found to be increased in transgenic tobacco leaves, as well as the enzyme activities of the protective enzymes: peroxidase (POD), superoxide dismutase (SOD) and catalase (CAT) were significantly higher than those of the WT, and the malondialdehyde (MDA) content was lower than the WT. These results indicated that the introduction of EuSIP5 gene into tobacco increased the expression of drought-related genes, enhanced the anti-membrane oxidation ability of tobacco, and reduced the oxidative stress damage, thus improving the drought resistance of tobacco.

Preprint ARTICLE | doi:10.20944/preprints202408.1040.v1

Creation of an Experimental Animal Model for the Study of Postmortal Dark Scleral Spots

Matteo Nioi, Pietro Emanuele Napoli, Domenico Nieddu, Alberto Chighine, Maurizio Fossarello, Ernesto D'Aloja

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: postmortal scleral spots; postmortem tache noire; forensic ophthalmology; eye postmortem; ocular surface; sclera; animal models; postmortem interval; postmortem optical coherence tomography

Online: 14 August 2024 (18:04:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0580.v1

Optical Properties of Yttrium Orthoferrite Films Prepared by Plasma Laser Deposition

Dinara Sobola, Saleh H. Fawaeer, Pavla Kočková, Richard Schubert, Rashid Dallaev, Tomáš Trčka

Subject: Engineering, Electrical And Electronic Engineering Keywords: yttrium orthoferrite; plasma laser deposition; optical properties; thin films; bandgap; optoelectronics

Online: 8 August 2024 (12:03:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0303.v1

Characterisation of the Mitochondrial Genome of Capulus danieli: Insights into Evolutionary History and Ecological Adaptations

Yaoyu Xie, Yida Han, Junxia Mao, Xubo Wang, Zhenlin Hao, Ying Tian

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Capulus danieli; mitochondrial genome; protein-coding genes; divergence time estimation

Online: 6 August 2024 (03:19:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0237.v1

Emotional Intelligence Increases Nurses’ Work Performance: Evidence from Greece

Petros Galanis, Aglaia Katsiroumpa, Ioannis Moisoglou, Konstantina Derizioti, Parisis Gallos, Maria Kalogeropoulou, Vasiliki Papanikolaou

Subject: Public Health And Healthcare, Nursing Keywords: emotional intelligence; work performance; job performance; nurses; emotions

Online: 5 August 2024 (08:18:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2276.v1

Understanding the Mellowing Effect of Bottle Aging on the Sensory and Aesthetic Perceptions of Varietal Dry White Wines

Giovanni Marasà, Joana Ferreira, Mariana Mota, Manuel Malfeito-Ferreira

Subject: Biology And Life Sciences, Food Science And Technology Keywords: fine wines; aging bouquet; vertical tasting; maturation; quality; complexity; sensory space; aroma; mouthfeel

Online: 29 July 2024 (10:07:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1835.v1

Population-Based Incidence and Mortality Rates of Hematologic Malignancies regarding the Adult Population of Crete, Greece, and Analyses of Their Time Trends and Their Geographical Dis-Tribution: A First Approach from the Cancer Registry of Crete (CRC) for a 22-Year Time Period (1992–2013)

Stelios Lionakis, Dimitra Sifaki-Pistolla, Helen A. Papadaki, Dimitrios Mavroudis, Christos Lionis

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: hematologic neoplasms; incidence; mortality; cancer epidemiology; kaplan meier estimate; registries; spatio-temporal analysis

Online: 24 July 2024 (07:10:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1521.v1

Forecasting Temperature Trends Using SARIMAX: A Case Study in Ahmedabad City, India

Vyom Shah, Nishil Patel, Dhruvin Apurva Shah, Debabrata Swain, Manorama Mohanty, Biswaranjan Acharya, Vassilis C. Gerogiannis, Andreas Kanavos

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: temperature forecasting; weather forecasting; time series; augmented Dickey-Fuller test; seasonal autoregressive integrated moving average with eXogenous factors (SARIMAX); root mean squared error; seasonality; climate change

Online: 18 July 2024 (14:27:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0867.v1

PlanteSaine: An Artificial Intelligent empowered mobile application for pests and disease management for maize, tomato, and onion farmers in Burkina Faso

Obed Appiah, Kwame Oppong Hackman, Belko Abdoul Aziz Diallo, Kehinde O. Ogunjobi, Son Diakalia, Ouedraogo Valentin, Damoue Abdoul-Karim, Gaston Dabire

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Artificial Intelligence in Agriculture; Pest and Disease Detection; Mobile Application for Farmers; Burkina Faso Agriculture; Real-time Plant Diagnosis; Sustainable Farming Practices

Online: 13 June 2024 (11:52:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0826.v1

Sequential Behavior of Broiler Chickens in Enriched Environments Under Varying Thermal Conditions Using the Generalized Sequential Pattern Algorithm: A Proof of Concept

Juliana M. Massari, Daniella J. Moura, Irenilza A. Nääs, Danilo F. Pereira, Stanley R. M. Oliveira, Tatiane Branco, Juliana de S. G. Barros

Subject: Engineering, Bioengineering Keywords: animal behavior; animal welfare; data mining; environment; machine learning; precision livestock farming

Online: 12 June 2024 (11:25:20 CEST)

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Behavior analysis is a widely used non-invasive tool in the practical production routine, as the animal acts as a biosensor capable of reflecting its degree of adaptation and discomfort to some environmental challenge. Predominantly, conventional statistics use occurrence data for behavioral evaluation and well-being estimation, disregarding the temporal sequence of events. The Generalized Sequential Pattern (GSP) algorithm is a data mining method that identifies recurrent sequences that exceed a user-specified support threshold, whose potential has not yet been investigated for broiler chickens in enriched environments. Enrichment aims to increase environmental complexity with promising effects on animal welfare, stimulating priority behaviors and potentially reducing the deleterious effects of heat stress. The objective was to validate the application of the GSP algorithm to identify temporal correlations between heat stress and the behavior of broiler chickens in enriched environments through proof of concept. Video image collection was carried out automatically for 48 continuous hours, analyzing a continuous period of seven hours, from 12:00 PM to 6:00 PM, during two consecutive days of tests for chickens housed in enriched and non-enriched environments under comfort and stress temperatures. Chickens at comfort temperature showed high motivation to perform the behaviors of Preening (P), Foraging (F), Lying down (Ld), Eating (E), and Walking (W) whose sequences <{Ld,P}>; <{Ld,F}>; <{P,F,P}>; <{Ld,P,F}> and <{E,W,F}> were the only ones observed in both treatments. All other sequential patterns (comfort and stress) were distinct, suggesting that environmental enrichment alters the behavioral pattern of broiler chickens. Heat stress drastically reduced the sequential patterns found at the 20% threshold level in the tested environments. The behavior of lying laterally "Ll" is a strong indicator of heat stress in broilers and was only frequent in the non-enriched environment, which may suggest that environmental enrichment provides the animal with better opportunities to adapt to stress-inducing challenges, such as heat.

Preprint ARTICLE | doi:10.20944/preprints202406.0391.v1

Laser-Assisted versus Open Cordectomy for Early Glottic Cancer

Christine Langer, Florian Glatt, Steffen Wagner, Michael Knitschke, Shachi Jenny Sharma, Claus Wittekindt

Subject: Medicine And Pharmacology, Otolaryngology Keywords: cordectomy; open approach; functional outcome; early glottic cancer; head and neck cancer

Online: 6 June 2024 (12:40:32 CEST)

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Purpose: Early glottic cancer is a highly curable malignancy. Disease control is achieved by resec-tion or external beam radiation with similar long-term results according survival. Surgery is predominantly performed by transoral endoscopic approach, due to reduced complication rates when compared to open cordectomy. Open cordectomy might still be warranted in cases of inad-equate surgical accessibility. Aim of the present study was to compare endoscopic versus open approach in relation to complications and outcome in an up-to-date patient group. Methods: 219 patients underwent primary tumor resection in early glottic cancer (UICC stages I-II). 168 opera-tions were performed endoscopically, 51 operations were open transcervical cordectomies. We compared survival data with non-parametric methods and functional outcome according to need of tracheostomy, feeding tube and voice functional outcome following ELS protocol. Results: There were no significant differences in overall survival (OS). 2 years OS after endoscopic surgery was 90.5% vs 95.3% after transcervical resection. As expected, OS in T1b and T2 tumors was worse than in T1a tumors. We found a statistically significant difference in disease free survival (DFS) within the T1a and T1b/T2 group (Log rank test: p=0.006) but no relevant difference be-tween the two surgical modalities, even when the data was stratified by T-categories performing a Cox regression (hazard ratio 1.21, p=0.712). Patients who underwent open surgery had a sig-nificantly worse peri- and postoperative course with longer hospital stay, higher frequency of tracheotomies and longer need for nasogastric tubes. Functional results were comparable within the two patient groups while higher tumor size / stage was an unfavorable predictor for voice re-habilitation. Conclusion: Open cordectomy leads to more complications but offers comparable oncological and functional outcome when compared to transoral endoscopic approach in early glottic cancer. Open surgery therefore continues to be a valid treatment option when endoscopic resection is not possible.

Preprint REVIEW | doi:10.20944/preprints202405.1689.v1

Bibliometric Analysis of Patient Safety in Nursing

Nükhet BAYER, Güney GÜRSEL, Ömer TURUNÇ, İbrahim Sani MERT, Müzeyyen Çiğdem AKBAŞ, Melih ALTAY, Cem ŞEN, Tamer KILIÇ

Subject: Public Health And Healthcare, Nursing Keywords: Bibliometric analysis; patient safety; nursing care

Online: 27 May 2024 (08:36:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0697.v1

Reduced Pharmacological Intervention of Prehospital Services for Acute Alcohol Intoxication during the COVID-19 Pandemic in a Large District of Southern Italy

Arcangela Giustino, Annamaria Natola, Giovanni Savoia, Maria Antonietta De Salvia, Carmine Finelli

Subject: Medicine And Pharmacology, Internal Medicine Keywords: emergency service; acute alcohol intoxication; triage; pharmacological treatment; public health

Online: 10 May 2024 (18:32:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1597.v1

Deciphering the Interplay: Thieno[2,3-b]pyridine Impact on Glycosphingolipid Expression, Cytotoxicity, Apoptosis, and Metabolomics in Ovarian Tumor Cell Lines

Zdravko Odak, Sandra Marijan, Mila Radan, Lisa I. Pilkington, Monika Čikeš Botić, David Barker, Jóhannes Reynisson, Vedrana Čikeš-Čulić

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: ovarian cancer, glycosphingolipids (GSLs), apoptosis, cytotoxicity, metabolomics, thieno[2,3-b]pyridine, cancer stem cells (CSCs)

Online: 24 April 2024 (10:06:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1363.v1

Status and Challenges of Medical History-Taking in Developing Countries and an Affordable Digital Solution to Tackle Them

Forhad Hossain, Mohamed Mehfoud Bouh, Md Moshiur Rahman, Faiz Shah, Tsunenori Mine, Rafiqul Islam, Naoki Nakashima, Ashir Ahmed

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Health Informatics; Digital Health; Physicians’ Workload; History Taking Challenges; Electronic Health Records (EHR); Modern Healthcare System; Artificial Intelligence; Life-long Medical History; Healthcare Data Management; Healthcare Innovation

Online: 21 April 2024 (05:28:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1265.v1

The Influence of Gender on the Psychiatric Comorbidity of Treated Danish Patients With and Without Alcoholism

Elizabeth C Penick, Waheeda A. Hossain, Wendy Madarasz, Ann M Manzardo, Joachim Knop, Erik L Mortensen, William F Gabrielli

Subject: Public Health And Healthcare, Health Policy And Services Keywords: Alcohol use disorder; Gender; Psychiatric comorbidity

Online: 19 April 2024 (09:56:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0991.v1

Rethinking the Esterquats: Synthesis, Stability, Ecotoxicity and Applications of Esterquats Incorporating Analogs of Betaine or Choline as the Cation in Their Structure

Marcin Wysocki, Witold Stachowiak, Mikołaj Smolibowski, Adriana Olejniczak, Michał Niemczak, Julia L. Shamshina

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: Quaternary Ammonium Salts; Cleavable Compounds; Esters; Environmental Safety; Cationic Surfactants; Biological Activity

Online: 15 April 2024 (14:53:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0967.v1

Exploring the Immune-Related Senescence biomarkers in Predicting Gestational Diabetes Mellitus

Yanqiong Gan, Jing Mao, Yuhan He, Zhaoxia Chen, Bo Fan, Qi Shi, Hongbo Qi

Subject: Biology And Life Sciences, Aging Keywords: Gestational Diabetes Mellitus; immune infiltration; senescence; WGCNA, machine learning; CECR1; TACC2

Online: 15 April 2024 (13:23:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0032.v1

Transcranial Direct Current Stimulation: Effects on Motor and Non-Motor Symptoms of Parkinson's Disease

Fayda Protásio, Carlos Tomaz, Joaquim Brasil-Neto, Pedro Brandão, Nasser Allam, Maria Clotilde Henriques Tavares

Subject: Biology And Life Sciences, Behavioral Sciences Keywords: Parkinson’ s disease; neuromodulation; transcranial direct current stimulation – tDCS; movement disorders; mood; sleep; cognition

Online: 1 April 2024 (09:56:57 CEST)

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Abstract Introduction: In the last thirty years, brain neuromodulation techniques have been used as an alternative to pharmacological treatment of neurological disorders. Parkinson's disease (PD) is a neurodegenerative disorder leading to bradykinesia, rest tremor, postural changes, and non-motor symptoms such as depression, anxiety, sleep disorders, pain, and cognitive decline that compromises executive functions (EFs), responsible for the orderly execution of behaviors and tasks of daily life and intentional and directed actions. To this date, a few studies with transcranial direct current stimulation (tDCS) have shown beneficial effects in PD patients concerning specific motor and non-motor symptoms, targeting the motor cortex and/or prefrontal regions. Objective: The main objective of this study was to evaluate the effects of left prefrontal tDCS across a broad spectrum of motor and non-motor symptoms of PD using established validated scales. Method: Single-blind randomized clinical trial with 18 volunteers with PD, aged between 45 and 80 years (66.1 ± 9.65), who met inclusion and exclusion criteria. Participants were submitted to assessments of motor and non-motor functions employing psychometric scales and tests to evaluate EFs and were randomly divided into two groups: control (sham stimulation) and experimental (active stimulation). All participants were involved in three separate tDCS sessions. The anode was positioned over the left dorsolateral prefrontal cortex and the cathode over the right supraorbital region, with a direct current intensity of 2mA, lasting 20 minutes. At the end of the three sessions, all participants were reassessed. Results: Significant effects of tDCS on non-motor functions were observed for cognition (verbal fluency of actions, clock copy test, appointment by visual confrontation, and verbal memory with immediate free recall) and subjective assessment of sleep quality (overall restlessness and discomfort in the arms and legs at night, leg and arm cramps at night and distressing dreams). There was also an improvement in the rate of errors and successes for congruent and incongruent stimuli of the Stroop Test. The beneficial effects on motor function were decreased rigidity, improved gait, and greater agility in the finger-tapping test. Conclusion: Three tDCS sessions showed positive results for participants with PD, producing significant improvements in various motor and non-motor functions, including sleep quality, cognition, and EFs. Additionally, the present results indicate that tDCS neuromodulation of the left dorsolateral prefrontal cortex region is feasible, safe, and provides significant objective benefits for PD patients.

Preprint ARTICLE | doi:10.20944/preprints202403.1849.v1

Long-Term Organic Cultivation in Greenhouses Enhances Vegetable Yield and Soil Carbon Accumulation through the Promotion of Soil Aggregation

Lihong Tong, Yingjun Liu, Tian Lan, Xiayan Liu, Lechuan Zhang, Adu Ergu, Yajie Wen, Xiang Liu

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: organic cultivation; soil aggregates; organic carbon fraction; microbial community; enzyme activity

Online: 29 March 2024 (13:20:51 CET)

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The long-term use of fertilizers and pesticides in conventional cultivation has resulted in a decrease in soil productivity and vegetable yields in greenhouses. However, only a limited number of studies have explored the impacts of organic cultivation on greenhouse soil. Specifically, there is a scarcity of research examining the alterations in soil aggregate mediated organic carbon and microbial communities, which are known to enhance soil productivity. This study investigated the properties of soil aggregates, including the levels of organic carbon fractions, microbial community, and enzyme activity with the three aggregate classes microaggregates (<0.25 mm), small macroaggregates (2-0.25 mm) and large macroaggregates (>2 mm). These investigations were conducted under three different cultivation methods in a greenhouse: conventional cultivation (CC), integrated cultivation (IC), and organic cultivation (OC) in greenhouse. The results showed that (1) OC and IC promoted the formation of small macro-aggregates and enhanced aggregate stability compared to CC, (2) SOC in the three size fractions of OC increased by 98.99%-92.06% compared to CC; EOC increased by 98.47%-117.59%; POC increased by 138.59%-208.70%; MBC increased by 104.71%-230.61%; DOC increased by 21.93%-40.90%, respectively; (3) Organic cultivation significantly increased enzyme activity in all three particle size aggregates and increased the relative abundance of bacteria in micro-aggregates as well as the relative abundance of fungi in small macro-aggregates. Structural equation model (SEM) analysis revealed that organic farming practices fostered the development of smaller macro-aggregates, elevated microbial and enzyme activities within soil aggregates, and facilitated the conversion of soil nutrients and carbon sequestration. consequently, this led to an increase in soil organic carbon content and improved vegetable yield in greenhouse environments. In conclusion, the soil carbon content and vegetable yield are enhanced through long-term organic cultivation in greenhouses, primarily by increasing the proportion of small macro-aggregates.

Preprint ARTICLE | doi:10.20944/preprints202403.1519.v1

Clinical Significance of the Immunohistochemical Expression of Histone Deacetylases (HDACs)-2, -4 and -5 in Ovarian Adenocarcinomas

Georgia Levidou, Dimitrios Arsenakis, Dimitrios I Bolovis, Roxanne Meyer, Cosima VM Brucker, Thomas Papadopoulos, Stamatios Theocharis

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: HDAC; ovarial adenocarcinoma; immunohistochemistry; prognosis

Online: 26 March 2024 (06:47:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1410.v1

The Outcome of the Psychological and Therapeutical Care of Hospitalized COVID-19 Patients: National African Pilot Study

Yassine BENHADDOUCH, Nour ELhouda Fares, Soumaya BENMAAMAR, Youssef OUAZZANI HOUSNI TOUHAMI, Amine BOUT, Chadya AARAB, Said BOUJRAF, Rachid AALOUANE

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Anxiety; depression; post-traumatic stress; hydroxychloroquine; family support; intensive care

Online: 25 March 2024 (08:08:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1264.v1

Prevalence of Condom Use and Associated Factors among Undergraduate Students of Gulu University.

Brian Otim, Jerom Okot, Ritah Nantale, Winnie Kibone, Grace Madraa, Christopher Okot, Felix Bongomin

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Undergraduates; condom use; associated factors; Uganda

Online: 21 March 2024 (08:55:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0331.v1

Application of Optimal Scheduling for SAR Satellite Constellation: Multi-Imaging Mission in High-Density Regional Area

Kimoon Lee, Dongjin Kim, Daewon Chung, Seonho Lee

Subject: Engineering, Aerospace Engineering Keywords: Optimal scheduling; Synthetic Aperture Radar (SAR); Satellite constellation; Multi-imaging mission; High-density regional area; Modified Dynamic Programming (MDP)

Online: 6 March 2024 (07:13:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0070.v1

Aggressiveness in Italian Children with ADHD: Maoa Gene Polymorphisms Involvement

Ludovico Neri, Beatrice Marziani, Pierluigi Sebastiani, Tiziana Del Beato, Alessia Colanardi, Maria Pia Legge, Anna Aureli

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: ADHD; Aggressive behavior; MAOA; 5-HTT.

Online: 4 March 2024 (01:25:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1559.v1

Enhancing Thermal Conductivity of CNT/AlN/Silicone Rubber Composites through Directly Grown CNTs on AlN for Reduced Filler Filling Ratio

Naoyuki Matsumoto, Don N. Futaba, Takeo Yamada, Ken Kokubo

Subject: Chemistry And Materials Science, Nanotechnology Keywords: Carbon Nanotubes; Thermal conductivity; Aluminum Nitride; Chemical vapor deposition; Anti-hydrolysis; Mechanical property

Online: 27 February 2024 (14:42:29 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0825.v1

Current Knowledge on the Use of Neuromonitoring in Thyroid Surgery

Beata Wojtczak, Karolina Sutkowska-Stępień, Mateusz Głód, Krzysztof Kaliszewski, Krzysztof Sutkowski, Marcin Barczyński

Subject: Medicine And Pharmacology, Surgery Keywords: recurrent laryngeal nerves; thyroid surgery; intraoperative nerve monitoring; vocal fold paresis

Online: 15 February 2024 (11:35:59 CET)

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Preprint CASE REPORT | doi:10.20944/preprints201701.0136.v1

Eco-Safety Assessment of Glyoxal-Containing Cellulose Ether on Freeze-Dried Microbial Strain, Cyanobacteria, Daphnia, and Zebrafish

Chang-Beom Park, Min Ju Song, Nak Woon Choi, Sunghoon Kim, Hyun Pyo Jeon, Sanghun Kim, Youngjun Kim

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Aquatic-toxic effects; EU chemical regulation; Glyoxal-containing cellulose ether

Online: 31 January 2017 (12:10:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints201610.0044.v1

Using MODIS Data to Predict Regional Corn Yields

Ho-Young Ban, Kwang Soo Kim, No-Wook Park, Byun-Woo Lee

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: MODIS; yield; phenology; LAD; logistic function

Online: 13 October 2016 (04:40:10 CEST)

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A simple approach was developed to predict corn yields using the MoDerate Resolution Imaging Spectroradiometer (MODIS) data product from two geographically separate major corn crop production regions: Illinois, USA and Heilongjiang, China. The MOD09A1 data product, which are 8-day interval surface reflectance data, were obtained from day of the year (DOY) 89 to 337 to calculate the leaf area index (LAI). The sum of the LAI from early in the season to a given date in the season [end of DOY (EOD)] was well fitted to a logistic function and represented seasonal changes in leaf area duration (LAD). A simple phenology model was derived to estimate the dates of emergence and maturity using the logistic function parameters b1 and b2, which represented the rate of increase in LAI and the date of maximum LAI, respectively. The phenology model predicted emergence and maturity dates fairly well, with root mean square error (RMSE) values of 6.3 and 4.9 days for the validation dataset, respectively. Two simple linear regression models (YP and YF) were established using LAD as the variable to predict corn yield; the yield model (YP) used LAD from predicted emergence to maturity, and the yield model (YF) used LAD for a predetermined period from DOY 89 to a particular EOD. When state/province corn yields for the validation dataset were predicted at DOY 321, near completion of the corn harvest, the YP model performed much better than the YF model, with RMSE values of 0.68 t/ha and 0.66 t/ha for Illinois and Heilongjiang, respectively. The YP model showed a similar or better performance, even for the much earlier yield prediction at DOY 257, compared to that of the YF model. In conclusion, the phenology and yield models were developed based only on logistic changes in remote sensing-derived LAD, and predicted phenological dates and corn yields with considerable accuracy and precision for the two regions selected for this study. However, these models must be examined for spatial portability in more diverse agro-climatic regions.

Preprint ARTICLE | doi:10.20944/preprints201608.0189.v1

Promoting Effect of Inorganic Alkali on Carbon Dioxide Adsorption in Amine-Modified MCM-41

Yang Teng, Lijiao Li, Gang Xu, Kai Zhang, Kaixi Li

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: amine-modified MCM-41; CO2 adsorption; inorganic alkali; alkali amounts

Online: 22 August 2016 (05:47:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1855.v1

Antimicrobial Susceptibility of Uropathogenic Escherichia coli with Analysis of Impact of Socio-Economic Factors in Low, Medium and High-Income Countries

Meher Rizvi, Maria Khan, Amina AL Jardani, Ujjala Ghoshal, Zaaima AL Jabri, Mohammad Ahanjan, Azza AL Mamari, Nawal AL Shizawi, Hiba Sami, Abdullah Balkhair, Adila Shaukat, Alwarith Nasser Salem Alkharusi, Abdulrahman Almahrouqi, Afreenish Hassan, Ajay Kumar, Amal Malehi, Amina Gul, Ashima Singh, Asma Said Hamed AL Shidhani, Areena Hoda Siddiqui, Aruna Poojary, Azza AL Rashdi, Bradley Langford, Dmytro Stepanskyi, Abbas Dolatabadi, Aisha Al Mufraji AL Mufraji, Elham Said Ahmed AL Risi, Garima Kapoor, Isabella Princess, Hatim Ali Eltahir, Hilal Al Sidairi, Kaitlyn Dougherty, Katia Iskandar, Ken Masters, Ibrahim Khalaf Hamdan AL Busaidi, Laila AL Yazidi, Mahfuza Nasrin, Mahmood Salim AL Subhi, Mallika Sengupta Mallika Sengupta, Manisha Khandait, Nada Khalfan AL Tamtami, Nada Khafan Alsiyabi, Nawal AL Kindi, Nazla Musthafa Luthfee, Neha Shreshtha, Nihal Mohamed Amur AL Riyami, Noora Hilal Ali AL Busaidi, Nupur Goel, Oksana Ishchenko, Omnia Mohamed Elnabawy Ahmed Taher, Pragnya Paramita Jena, Rajni Ekadashi, Razan Zadjali, Reba Kanungo, Sara Abolghasemi, Salima Al-maqbali, Sanjay Jaju, Sayantan Banerjee, Shadma Yaqoob, Shahnaz Sali, Shafqat Husnain Khan, Shalini Malhotra, Stephen Hughes, Sundas Shaukat, Syed Mohammed Atif, Vrushali Vishwas Patwardhan, Victorien Dougnon, Wahid Khan, Walid Wali, Zakariya AL Muharrmi, Zeeshana Basit, Jasashree Choudhury, Rachita Pravalina, Sanjeev Singh, Sarman Singh, Neelam Taneja, Raman Sardana, Pawan Kapoor, Rajeev Soman, Rashid Al Abri

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: community acquired UTI; Escherichia coli; antimicrobial susceptibility; Indian subcontinent; MENA; GDP; temperature

Online: 24 September 2024 (12:32:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2214.v1

Scalable O(log2n) Dynamics Control for Soft Exoskeletons

Julian D. Colorado, Diego Mendez, Andres Gomez-Bautista, John E. Bermeo, Catalina Alvarado-Rojas, Fredy Cuellar

Subject: Engineering, Bioengineering Keywords: soft-exoskeletons; parallel computing; embedded systems; HIL; dynamics contro

Online: 29 September 2024 (03:40:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0398.v1

Dynamics of Rumour Spread with Moral Etiquette Class

Timothy Ado Shamaki, S. Musa, A.B. Aihomg

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: dynamics; rumour; spread of rumour; mathematical modelling; moral etiquette

Online: 4 July 2024 (08:45:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1444.v1

Bubble dynamics in the Polyakov quark-meson model

Junrong Wang, Jinshuang Jin, Hong Mao

Subject: Physical Sciences, Nuclear And High Energy Physics Keywords: the quark-meson model; bounce; the surface tension; nucleation; QCD phase transition

Online: 21 June 2024 (05:31:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0232.v1

Reappraising Double Pendulum Dynamics across Multiple Computational Platforms

Sandy Herho, Faiz Fajary, Katarina Herho, Iwan Anwar, Rusmawan Suwarman, Dasapta Irawan

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: chaotic dynamics; Computational Platforms; nonlinear dynamics; numerical simulations; Sensitivity Analysis ;

Online: 6 May 2024 (10:01:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1557.v1

Exploring Seizure Dynamics: A Computational Model of Epilepsy

Richard Murdoch Montgomery

Subject: Biology And Life Sciences, Biophysics Keywords: Epilepsy Dynamics
Computational Model

Online: 24 April 2024 (05:12:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0615.v1

Recycling Reinforced: The Synergistic Dynamics of Sustainable Behavior

Ebru Enginkaya, MUNİSE HAYRUN SAĞLAM

Subject: Business, Economics And Management, Marketing Keywords: pro-environmental behavior; recycling; sustainability; self-efficacy; social pressure; feelings of pride

Online: 9 April 2024 (08:44:43 CEST)

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Preprint ESSAY | doi:10.20944/preprints202404.0506.v1

Neural Networks through the Lens of Evolutionary Dynamics

Dan C. Baciu

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: Evolutionary dynamics; Neural Networks; Self-attention; Variation-selection; Frequency Dependent Selection

Online: 8 April 2024 (06:11:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1873.v1

On complex dynamics in a Suris's integrable map

Yasutaka Hanada, Akira Shudo

Subject: Physical Sciences, Mathematical Physics Keywords: dynamical tunneling; integrable map; complex classical dynamics

Online: 1 April 2024 (10:14:39 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202402.1215.v1

Exact Renormalization Group Dynamics through Schrödinger-Type Equations

Anna Maria Wojtyra, Matthew James Stephenson

Subject: Physical Sciences, Mathematical Physics Keywords: Exact Renormalisation Group; Quantum Mechanics; Schrö; dinger-Type Equation; Wilsonian Renormalisation Group; Quantum Field Theory; Functional Quantum Mechanics; Inflation; Scalar Field

Online: 21 February 2024 (15:02:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1547.v1

Physics-Based Aircraft Dynamics Identification Using Genetic Algorithms

Raymundo Peña-García, Rodolfo Daniel Velázquez-Sánchez, Cristian Gómez-Daza-Argumedo, Jonathan Omega Escobedo-Alva, Ricardo Tapia-Herrera, Jesús Alberto Meda-Campaña

Subject: Engineering, Aerospace Engineering Keywords: Physical-based modelling; system identification; transition matrix; genetic algorithm.

Online: 20 December 2023 (13:49:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0144.v1

Redefining Textual Dynamics for Enhanced Text Style Transfer

Carlos Asanka, Conti Vatsalan, Rodolfo Patel

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Syntax-Aware Text Transformation; ; Style Classifier Analysis

Online: 4 December 2023 (06:53:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0308.v1

Application of Gradient Optimization Methodsin Defining Neural Dynamics

Predrag S. Stanimirović, Nataša Tešić, Dimitrios Gerontitis, Gradimir V. Milovanović, Milena J. Petrović, Vladimir L. Kazakovtsev, Vladislav A. Stasiuk

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: gradient neural network; generalized inverses, Moore-Penrose inverse; linear matrix equations

Online: 6 November 2023 (08:01:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0076.v1

Exotic Particle Dynamics using Novel Hermitian Spin Matrices

Timothy Ganesan

Subject: Physical Sciences, Mathematical Physics Keywords: exotic particle dynamics; generalized hermitian spin matrices; Pauli matrices; electrodynamics; fermionic quantum Heisenberg model; bosonic spin systems

Online: 3 October 2023 (05:40:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1444.v1

Opinion Dynamics Explain Price Formation in Prediction Markets

Valerio Restocchi, Frank McGroarty, Enrico Gerding, Markus Brede

Subject: Business, Economics And Management, Finance Keywords: opinion dynamics; econophysics; prediction markets; complex networks; agent-based modelling

Online: 21 July 2023 (08:12:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0474.v1

Mathematical Programming for the Dynamics of Opinion Diffusion

Andrea Ellero, Giovanni Fasano, Daniela Favaretto

Subject: Physical Sciences, Other Keywords: Sociophysics; Stochastic Models; Galam’s Diffusion Model; Mathematical Programming; Parameter Optimisation

Online: 7 July 2023 (10:38:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0389.v1

Entropic Dynamics in a Theoretical Framework for Biosystems

Richard L Summers

Subject: Biology And Life Sciences, Biophysics Keywords: entropic dynamics; biosystems; Kullback Principle of Minimum Information Discrimination; biocontinuum; information geometry

Online: 22 February 2023 (15:32:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0472.v1

Novel Learning for Control of Nonlinear Spacecraft Dynamics

Bo-Ruei Huang, Timothy Sands

Subject: Engineering, Mechanical Engineering Keywords: nonlinear systems; mechanics; spacecraft attitude control; deterministic artificial intelligence; regression, learning

Online: 26 January 2023 (08:34:42 CET)

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Preprint REVIEW | doi:10.20944/preprints202212.0374.v1

System Dynamics Tools to Study Mediterranean Rangeland’s Sustainability

Jaime Martínez-Valderrama, Javier Ibáñez

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Drylands; mediterranean; Early Warning Systems; Sensitivity Analysis; Desertification

Online: 21 December 2022 (02:33:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202209.0155.v1

Collatz Dynamics is Partitioned by Residue Class Regularly

Wei Ren

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Collatz conjecture; 3x+1 problem; Dynamics System; Residue Class

Online: 13 September 2022 (03:21:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0035.v1

Ultrafast Carrier Dynamics in Two Dimensional NbTe₂ Films

David Moss

Subject: Physical Sciences, Optics And Photonics Keywords: Layered transition metal dichalcogenides; NbTe2 flake; ultrafast carrier dynamics; pump-probe spectroscopy

Online: 6 April 2022 (08:31:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0146.v1

Dynamics of Community Gardening: A Catalyst for Health

Donald N. Roberson, Jr., Michal Kudlacek

Subject: Social Sciences, Tourism, Leisure, Sport And Hospitality Keywords: leisure; recreation; gardening; physical activity; natural landscapes

Online: 10 February 2022 (10:33:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202106.0720.v1

Research on Cadmium Adsorption-Desorption Dynamics of Biochars

Zhenyu Zhang, Shu Dang, Guiping Zheng, Haibo Li

Subject: Social Sciences, Anthropology Keywords: Biochar; Cadmium; Pyrolysis temperature; Adsorption kinetics; Desorption

Online: 30 June 2021 (09:10:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0151.v1

Hertz Elastic Dynamics of Two Colliding Elastic Spheres

Bohua Sun

Subject: Physical Sciences, Applied Physics Keywords: Hertz impact dynamics; exact solution; numerical solution; inversion; Maple

Online: 7 September 2020 (03:20:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202005.0158.v1

Dynamics of Bcl-2Protein Phosphorylation: A Mini Review

Abdul Manan, Sidra Ilyas

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: apoptosis; cancer; phosphorylation; kinases; Bcl-2

Online: 9 May 2020 (08:40:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0063.v1

Cancer Dynamics: Identification of States for Therapeutic Intervention

Amit Jangid, Md Zubbair Malik, Ram Ramaswamy, R. K. Brojen Singh

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: p53-Mdm2; mutant p53; oncogene; stress; regulatory network; cancer dynamics

Online: 5 May 2020 (05:55:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0296.v1

Collective Clustering Dynamics of SARS-COV-2 Particles

Arturo Tozzi, James F. Peters, Isabella Annesi-Maesano, Gennaro D'Amato

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: COVID-19; supernatant; sphere packing; electron microscopy; clustering

Online: 17 April 2020 (08:30:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0239.v2

Linear or non Linear modeling for ENSO dynamics?

Marco Bianucci, Antonietta Capotondi, Riccardo Mannella, Silvia Merlino

Subject: Environmental And Earth Sciences, Environmental Science Keywords: El Nino Southern Oscillation; ENSO, El Nino extreme events;

Online: 7 November 2018 (16:30:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0206.v1

One-Year Effect of Elexacaftor/Tezacaftor/Ivacaftor Therapy on HbA1c Levels and Insulin Requirement in Patients with Insulin-Dependent Cystic Fibrosis-Related Diabetes: A Retrospective Observational Study

Marta Bassi, Marina Francesca Strati, Gaia Spiandorello, Marta Scalas, Federico Cresta, Maria Grazia Calevo, Giuseppe D'Annunzio, Carlo Castellani, Nicola Minuto, Mohamad Maghnie, Rosaria Casciaro

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: CFRD; cystic fibrosis; diabetes; CFTR modulators; ETI treatment

Online: 4 September 2024 (04:52:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.2151.v1

Combining Ability of Capsicum annuum Hybrid for Antioxi-Dant Activities, Polyphenol Content, α-Glucosidase Inhibitory, Yield, and Yield Components

Muhamad Syukur, Awang Maharijaya, Waras Nurcholis, Arya Widura Ritonga, Arya Yuda Pangestu, Andi Nadia Nurul Lathifa Hatta, Muhammad Ridha Alfarabi Istiqlal, Abdul Hakim, Zulfikar Damaralam Sahid

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: α -glucosidase inhibition; antioxidant; combining ability; heterotic effect; polyphenol content

Online: 30 August 2024 (10:56:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0135.v1

Polyphenols Investigation, Antioxidant and Anticholinesterase Activity of Rosmarinus officinalis L. Species from Southwest Romania Flora

Ludovic Everard Bejenaru, Andrei Biţă, George Dan Mogoşanu, Adina-Elena Segneanu, Antonia Radu, Maria Viorica Ciocîlteu, Cornelia Bejenaru

Subject: Biology And Life Sciences, Plant Sciences Keywords: Rosmarinus officinalis; Romanian flora; polyphenols; UHPLC/MS quantification; antioxidant activity; anticholinesterase activity

Online: 2 August 2024 (10:36:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1711.v1

Dermatological Neoplastic Diseases Complicating Treatment with Monoclonal Antibody for Multiple Sclerosis

Floriana Bile, Maddalena Sparaco, Eleonora Ruocco, Giuseppina Miele, Elisabetta Maida, Renato Vele, Davide Mele, Simona Bonavita, Luigi Lavorgna

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Multiple Sclerosis; Skin cancer; Monoclonal antibodies.

Online: 22 July 2024 (11:47:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0982.v1

Implementation of a Grupal Intervention Program for the Treatment of Obesity in Children: PinPO.

MARIA JOSE COMINO-MONROY, WENCESLAO FERNANDEZ-GALLARDO, Mercedes Gil-Campos, MANGELES ALARCON-ROLDAN, CRISTINA CASTRO-COLLADO, BARBARA LUQUE, SEBASTIAN VIVAS, KATHERINE FLORES-ROJAS

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: childhood; grupal intervention; habits; obesity; treatment

Online: 12 July 2024 (05:57:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0327.v1

Genomic Landscape of Susceptibility to Severe COVID-19 in the Slovenian Population

Anja Kovanda, Tadeja Lukežič, Aleš Maver, Hana Vokač Križaj, Mojca Čižek Sajko, Julij Šelb, Matija Rijavec, Urška Bidovec-Stojković, Barbara Bitežnik, Boštjan Rituper, Peter Korošec, Borut Peterlin

Subject: Medicine And Pharmacology, Other Keywords: severe COVID-19; severe outcome of SARS-CoV-2 infection; whole-genome sequencing; WGS; genetic susceptibility; rare variants; human rare genomic variants

Online: 6 June 2024 (07:30:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1202.v1

Adaptive Evolution Signatures in Prochlorococcus: ORFeome Resources and Insights from Comparative Genomics

Daakour Sarah, David R. Nelson, Weiqi Fu, Ashish Jaiswal, Bushra Dohai, Amnah Salem Alzahmi, Joseph Koussa, Xiaoluo Huang, Yue Shen, Jean-Claude Twizere, Kourosh Salehi-Ashtiani

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Prochlorococcus; comparative genomics; deep learning; artificial neural networks; ORFeomes

Online: 17 May 2024 (16:05:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0162.v1

Comparison of Magnetic Resonance Imaging with Electrodiagnosis in the Evaluation of Lumbosacral Radiculopathy in Patients with Clinical Suspicion of the Pathology

Alberto Montaner-Cuello, Santos Caudevilla-Polo, Diego Rodríguez-Mena, Gianluca Ciuffreda, Pilar Pardos-Aguilella, Isabel Albarova-Corral, Jorge Pérez-Rey, Elena Bueno-Gracia

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Lumbosacral radiculopathy; Nuclear Magnetic Resonance Imaging; Electrodiagnostic studies; diagnostic tests

Online: 3 May 2024 (11:22:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1514.v1

PhyKIT: A Multitool for Phylogenomics

Jacob Steenwyk, Gemma Martínez-Redondo, Thomas Buida, Emile Gluck-Thaler, Xing-Xing Shen, Toni Gabaldón, Antonis Rokas, Rosa Fernández

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: phylogeny; phylogenomics; sequence alignments; genomics; software tools; comparative genomics

Online: 23 April 2024 (11:20:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1285.v1

Improving the Clinical Utility of Platelet Count in Primary Care with Age- and Sex-Stratified Upper Thresholds Suggestive of an Undiagnosed Cancer: A Cohort Study Set in Primary Care in England, Canada, and Australia

Luke T. A. Mounce, Raff Calitri, Willie Hamilton, Meena Rafiq, Jon D. Emery, Vasily Giannakeas, Joanne Kotsopoulos, Sarah E. R. Bailey

Subject: Public Health And Healthcare, Primary Health Care Keywords: cancer; diagnosis; primary care; family medicine; full blood count; platelet count

Online: 19 April 2024 (14:37:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1330.v1

Isoquinoline Alkaloids Interaction With Plasma Proteins

Aleksandra Marciniak, Aleksandra Kotynia, Edward Krzyżak, Żaneta Czyżnikowska, Sylwia Zielińska, Weronika Kozłowska, Marcel Białas, Adam Matkowski, Anna Jezierska-Domaradzka

Subject: Medicine And Pharmacology, Pharmacy Keywords: protopine; allocryptopine; albumin; orosomucoid; spectroscopy

Online: 19 April 2024 (10:26:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0503.v1

Formulation and Evaluation of Hydrophilic Matrix Tablets for Controlled Released Chlorzoxazone Delivery

Andreea Creteanu, Gabriela Lisa, Cornelia Vasile, Maria-Cristina Popescu, Daniela Pamfil, Claudiu N. Lungu, Gladiola Tantaru, Alina Diana Panaite

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: chlorzoxazone; collided; chitosan; matrix tablets; controlled release

Online: 8 April 2024 (07:15:31 CEST)

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The release of the active substance from the matrix modified-release tablets based on Kollidon®SR and chitosan depends on its solubility in the dissolution medium and on the composition of the matrix-forming polymers. The study is based on new oral matrix tablets based on Kollidon®SR and chitosan, formulated to optimize the low oral bioavailability of chlorzoxazone, a non-steroidal anti-inflammatory drug, a class II Biopharmaceutical Classification System. Nine types of chlorzoxazone matrix tablets were obtained using the direct compression method, and their combination at 1:1, 1:2, 1:3 chlorzoxazone/ excipients, 20%-40% (w/w) Kollidon®SR, 3-7% (w/w) chitosan and the auxiliary substances were formulated in constant concentrations. Pharmaco-technical characterization included the analysis of flowability and compressibility properties (flow time, friction coefficient, angle of repose, Hausner ratio, Carr Index), and of pharmaco-chemical characteristics (mass and dose uniformity, thickness, diameter, mechanical strength, Friability, degree of softening, in vitro release profile) of the tablets. Based on the initial evaluation of the pharmaco-technical analysis, pharmaco-chemical characteristics, and in vitro release profile, only three matrix tablet formulations (F1b, F2b, and F3b) were further tested. They were evaluated through Fourier-transform infrared spectrometry, X-ray Diffraction, thermogravimetry, differential scanning calorimetry, and in vitro dissolution tests. The three formulations were comparatively studied regarding the release kinetics of active substances using in vitro release testing. The results were analyzed by fitting into four representative mathematical models for the modified release oral formulations. In vitro kinetic study reveals a complex mechanism of release occurring in the first (0 - 2 hours) and second (2.0 hours – 36 hours) steps of drug release. Two factors have been calculated to assess the release profile of chlorzoxazone: f1 - the similarity factor and f2 - the factor difference. The results have shown that both Kollidon®SR and chitosan may be used as matrix-forming agents when combined with chlorzoxazone. In vitro dissolution tests revealed the F2b sample, data suggesting a faster drug release. The three formulations showed optimum pharmaco-technical properties and in vitro kinetic study, and they had tremendous potential to be used in oral pharmaceutical products for the controlled delivery of chlorzoxazone.

Preprint COMMUNICATION | doi:10.20944/preprints202404.0010.v1

Cytomegalovirus DNA Loads in Organs of Congenitally Infected Fetus

Kuniaki Toriyabe, Asa Kitamura, Makoto Ikejiri, Ryotaro Hashizume, Maki Nakamura, Emi Teramoto, Hiroki Takeuchi, Eiji Kondo, Tomoaki Ikeda

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: fetal autopsy; congenital cytomegalovirus; cytomegalic inclusion body; cytomegalovirus DNA

Online: 1 April 2024 (09:58:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1587.v1

Cultivation of Bovine MSCs on Plant-Based Scaffolds in a macrofluidic Single-Use Bioreactor for Cultured Meat

Gilad Gome, Benyamin Chak, Shadi Tawil, Dafna Shpatz, Jonathan Giron, Ilan Brajzblat, Chen Weizman, Andrey Grishko, Sharon Schlesinger, Oded Shoseyov

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: fluidics; bioreactors; tissue engineering; cultured meat; scaffolds

Online: 26 March 2024 (10:53:58 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.1401.v1

Plasma Metabolite Profiling in the Search for Early-Stage Biomarkers for Lung Cancer: Some Important Breakthroughs

Jill Meynen, Peter Adriaensens, Maarten Criel, Evelyne Louis, Karolien Vanhove, Michiel Thomeer, Liesbet Mesotten, Elien Derveaux

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: biomarkers; lung cancer; metabolomics; NMR (nuclear magnetic resonance)

Online: 25 March 2024 (07:06:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0682.v1

Influence of New Parameterization Schemes on Arctic Sea Ice Simulation

Yang LU, Xiaochun WANG, Yijun He, Jiping Liu, Jiangbo Jin, Jian Cao, Juanxiong He, Yongqiang Yu, Xin Gao, Mirong Song, Yiming Zhang

Subject: Environmental And Earth Sciences, Oceanography Keywords: Earth System Model; Sea Ice Parameterization Scheme; Arctic Sea Ice; Sea Ice Concentration; Sea Ice Thickness

Online: 12 March 2024 (10:29:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0166.v1

Infectious Diseases and Secondary Antibody Deficiency in Patients from a Mesoregion of São Paulo State

Luiz Euribel Prestes-Carneiro, Paula Andreia Martins Carrilho, Danimelle Francisco Honorato de Barros Torelli, Jose Antonio Nascimento Bressa, Ana Carolina Gomes Parizi, Pedro Henrique Meirelles Vieira, Fernanda Miranda Caliani Sa, Mauricio Domingues Ferreira

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Secondary Antibody Deficiency; hypo-γ -globulinemia; infectious diseases ;

Online: 4 March 2024 (15:50:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.2132.v1

Walkable Distances to School in Urban, Semi-Urban and Rural Areas: The PACO Y PACA Study

Iván Pinilla-Quintana, Evelyn Martín-Moraleda, Antonio Hernández-Martínez, Carmen Mota, María Teresa Martínez-Romero, Nuria Gómez, María Virginia García-Coll, Esther Cabanillas, Alberto Dorado-Suárez, Maria Paula Santos, Diane Marjorie Crone, Cristina Romero-Blanco, Javier Molina-García, Sandra Mandic, Fabio Jiménez-Zazo, Susana Aznar

Subject: Social Sciences, Transportation Keywords: active transport; walking; built environment; urbanicity; students; education; youth; teenagers

Online: 26 September 2024 (17:09:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1289.v1

The Sixth Mass Extinction and Amphibian Species Sustainability Through Reproduction Biotechnologies, Biobanking, Species Restoration, and Conservation Breeding Programs

Robert K. Browne, Qinghua Lou, Pei Wang, Nabil Mansour, Svetlana A Kaurova, Edith N Gakhova, Natalia V Shishova, Victor K Uteshev, Lyudmilla I Kramarova, Govindappa Venu, Mikhail F Bagaturov, Somaye Vaissi, Pouria Heshmatzad, Peter Janzen, Aleona Swegen, Julie Strand, Dale McGinnity

Subject: Biology And Life Sciences, Life Sciences Keywords: Mass extinction; COP 15; COP 28; reproduction technologies; intergenerational justice; de-extinction; climate catastrophe; assisted evolution; terraforming; space colonisation

Online: 17 September 2024 (11:33:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1424.v1

Characterization of Clostridioides difficile Persister Cells and Their Role in Antibiotic Tolerance

Osvaldo Inostroza, Paulina Yáñez, Giovanni Espinoza, Omar Fica, Camila Queraltó, José Rodríguez, Isidora Flores, Ruth González, Jorge A Soto, Juan A Fuentes, Iván L Calderón, Fernando Gil

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Clostridiodes difficile; Persisster cells; Antibiotic tolerance

Online: 20 June 2024 (14:46:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1245.v1

Association between Perinatal Outcomes and Maternal Risk Factors: Age, Body Mass Index and Cigarette Smoking

Raquel Martin-Alonso, Paula Prieto, Irene Fernandez Buhigas, Cristina German-Fernandez, Cristina Aramburu, Victor Piqueras, Diana Cuenca-Gomez, Emilia Ferrer, Valeria Rolle, Belen Santacruz, María M. Gil

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: cigarette smoking, body mass index, age, pregnancy, preeclampsia, diabetes, obesity, fetal, labour, birth weight.

Online: 20 May 2024 (08:55:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1081.v1

Useful Clinical Criteria for Identifying Neonates with Congenital Cytomegalovirus Infection at Birth in the Context of an Expanded Targeted Screening Program

Valeria Poletti de Chaurand, Gaia Scandella, Marianna Zicoia, Francesca Arienti, Federica Fernicola, Laura Lanteri, Diletta Guglielmi, Anna Carli, Maria Viola Vasarri, Lucia Iozzi, Annalisa Cavallero, Sergio Maria Ivano Malandrin, Anna Locatelli, Maria Luisa Ventura, Mariateresa Sinelli, Sara Ornaghi

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: Cytomegalovirus; screening; targeted; newborn; congenital; infection

Online: 16 May 2024 (10:49:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0852.v1

Ginkgo biloba: A Leaf of Hope in the Fight Against Alzheimer’s Dementia: Clinical Trial Systematic Review

Guilherme Lopes de Oliveira Pagotto, Livia Maria Oliveira dos Santos, Najwa Osman, Caroline Barbalho Lamas, Lucas Fornari Laurindo, Karina Torres Pomini, Leila M. Guissoni, Enzo Pereira de Lima, Ricardo de Alvares Goulart, Virginia M. C. Strozze Catharin, Rosa Direito, Masaru Tanaka, Sandra Maria Barbalho

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Alzheimer disease; cognitive dysfunction; Gingko biloba; EGb 761; terpenoids; flavonoids

Online: 12 April 2024 (12:37:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1581.v1

Safety, Tolerability and EEG-Based Target Engagement of STP1 (PDE3,4 Inhibitor and NKCC1 Antagonist), in a Randomized Clinical Trial in a Subgroup of Patients with ASD

Baltazar Gomez-Mancilla, Craig Erickson, Ernest V Pedapati, Eric Painbeni, Gregory Bonfils, Lauren M Schmitt, Hannah Sachs, Meredith Will, Lisa Destefano, Grace Westerkamp, Adriano De Souza, Oliver Pohl, Offir Laufer, Gil Issachar, Jean-Marc Hyvelin, Lynn A Durham

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: ASD-Phen1; STP1; ibudilast; bumetanide; phase 1b; EGG; NIH-TCB; SRS-2; ABC-C

Online: 26 March 2024 (10:20:29 CET)

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